| association of hepatitis viruses with hepatocellular carcinoma in thailand. | hepatocellular carcinoma (hcc) represents the most common form of malignant tumor among males in thailand, an area endemic for hepatitis b virus (hbv) infection. various risk factors have been associated with the development of hcc, among them exposure to certain toxins, and infection with hepatitis viruses, in particular hbv, as well as hcv in areas non-endemic for hbv infection. to examine the association of hepatitis viruses with hcc, our group investigated 101 patients who had been clinicall ... | 1999 | 10213123 |
| [the tt virus: another accidental tourist?]. | | 1999 | 10228327 |
| [detection of tt virus in hemodialysis patients]. | recently a newly discovered dna virus, transfusion transmitted virus (ttv), was introduced as a cause of post-transfusion hepatitis. we studied the frequency of ttv viremia in 60 hemodialysis patients in yamaguchi, japan. ttv dna was detected by heminested pcr, using primers described by okamoto et al. ttv dna was detected in 18 patients (30%). there was no differences in clinical characteristics, including age, gender, history of blood transfusion, and double infection of other hepatitis viruse ... | 1999 | 10391010 |
| improved detection systems for tt virus reveal high prevalence in humans, non-human primates and farm animals. | tt virus is a newly described agent infecting humans. initially isolated from a patient (initials t.t.) with unexplained hepatitis, the virus has since been found in both normal and diseased individuals. in the present study, we utilized genomic-length sequences from distinct genotypes of tt virus to design pcr-based assays using conserved oligonucleotide primers from three independent regions of the virus genome. each of the three assays was found to be superior to the pcr-based assays previous ... | 1999 | 10466810 |
| prevalence and implication of tt virus infection: minimal role in patients with non-a-e hepatitis in taiwan. | tt virus (ttv) is a newly identified human dna virus and little is known about its clinical significance. the aim of the study was to explore the prevalence of ttv infection in different risk populations and in patients with various liver diseases. viral dna was studied in 190 high-risk individuals, 97 household contacts, 52 patients with acute hepatitis a, 32 patients with non-a-e hepatitis including 13 fulminant hepatitis, 200 asymptomatic hepatitis b surface antigen (hbsag) carriers, 100 pati ... | 1999 | 10502261 |
| prevalence and clinical characteristics of tt virus (ttv) in patients with sporadic acute hepatitis of unknown etiology. | recently, a novel dna virus was isolated from the serum of a patient with post-transfusion non-a-g hepatitis and named tt virus. the aim of this study was to determine the prevalence and clinical characteristics of tt virus infection in patients with sporadic acute hepatitis of unknown etiology. | 1999 | 10604570 |
| non-enveloped viruses transmitted by blood and blood products. | since the advent of solvent detergent (s-d) treatment for inactivation of enveloped viruses, there has been no transmission of human immunodeficiency virus, hepatitis b virus, or hepatitis c virus by treated blood products. however, shortly after the introduction of s-d treatment, transmission of hepatitis a with s-d treated factor concentrates was reported in germany, italy, ireland, the united states and south africa, and this raised awareness of the potential for blood transmission of non-env ... | 2000 | 10794088 |
| tt virus infection in human immunodeficiency virus type 1 infected mothers and their infants. | serum tt virus (ttv) dna was determined in 83 human immunodeficiency virus type 1 (hiv 1) infected mothers [46 intravenous drug user and 37 non-intravenous drug user women] and their infants. twenty-nine (34.9%) mothers were ttv infected. infection was more frequent among intravenous drug user than non-intravenous drug user mothers [21/46 (45.6%) vs. 8/37 (21.6%); relative risk (rr): 2.1; 95% confidence limits (95% cl): 1.1-4.2; p = 0.023] and among intravenous drug users who carried on injectin ... | 2000 | 10861644 |
| tt virus infection during chronic hepatitis c. | the pathogenic role of tt virus (ttv) is not well known, especially during chronic hepatitis c virus (hcv) infection. we retrospectively investigated the presence of ttv dna in the plasma of patients with chronic hcv infection and compared the characteristics of ttv-dna-positive and -negative groups. | 2000 | 10925982 |
| emerging viral infections relevant to transfusion medicine. | the development of new technologies leads to the discovery of new viruses. for each of these new infectious agents relevance to transfusion needs to be assessed. the questions to be answered are transmissibility by transfusion, pathogenicity, prevalence in blood donors, persistence and the availability of screening assays. since 1995, three new viruses have been identified and extensively studied. gb virus-c/hepatitis g virus (gbv-c/hgv), a relatively rare virus with some homology with and epide ... | 2000 | 11124105 |
| interspousal transmission of tt virus: low efficiency and lack of apparent risk factors. | the tt virus (ttv) is a newly identified human dna virus and little is known about its non-parenteral transmission. the aim of the present study was to explore the prevalence of ttv infection in spouses of index cases and the related risk factors. | 2000 | 11129223 |
| high detection rates of ttv-like mini virus sequences in sera from brazilian blood donors. | tt virus (ttv) is an unenveloped virus with a single-stranded, circular dna genome of 3,818-3,853 nucleotides (nt) that infects humans and non-human primates. recently, the existence of a novel human virus, ttv-like mini virus (tlmv), that shows a genetic organization similar to that of ttv, but with smaller virion particle and genome, was proposed [takahashi et al. (2000) archives of virology 145:979-993]. to date, no information is available with respect to the prevalence and pathogenicity of ... | 2001 | 11505464 |
| tt virus mrnas detected in the bone marrow cells from an infected individual. | although replicative forms of tt virus (ttv) dna have been found in the liver and bone marrow cells, mrnas of ttv have not yet been detected in these tissues. the entire nucleotide sequence of a ttv clone [tym9 (3759 bases)] isolated from a patient with high ttv viremia (10(6) copies/ml) was determined, and the poly(a)(+) rnas from bone marrow cells were subjected to reverse transcription-polymerase chain reaction with primers specific for the tym9 sequence. sequence analysis of the amplified pr ... | 2000 | 11118348 |
| species-specific tt viruses in humans and nonhuman primates and their phylogenetic relatedness. | by means of polymerase chain reaction with a primer pair (ng133-ng147) deduced from the untranslated region (utr) of tt virus (ttv), ttvs with markedly distinct genomic lengths were recovered from sera of humans and nonhuman primates, and their entire nucleotide sequences were determined. a human ttv [tgp96 of 2908 nucleotides (nt)] was obtained that was about 900 nt shorter than heretofore reported ttvs (3787-3853 nt). likewise, ttvs of chimpanzee occurred in two distinct genomic sizes [pt-ttv6 ... | 2000 | 11080484 |
| fecal excretion of a novel human circovirus, tt virus, in healthy children. | the role of tt virus (ttv) as a human pathogen is unclear, as is the mode of ttv transmission. to determine the prevalence of ttv infection and the possible fecal-oral route of transmission, we analyzed fecal specimens from 67 healthy, nontransfused children for ttv dna sequences by heminested pcr, using the ng and t primer sets. the overall prevalence of ttv fecal excretion was 22.4% (15 of 67), with the t primer set (19.4%) being more sensitive than the ng primer set (10.4%). ttv prevalence ba ... | 2000 | 11063506 |
| [ttv: a new hepatitis virus? transfusion-transmitted virus]. | following the discovery of hepatitis c virus (hcv), it was clear that a proportion of cases with acute and chronic hepatitis are still negative for all known viral markers, which prompted investigations to search for new hepatitis agents. in 1997 investigators in japan isolated a dna clone of a novel human virus using a representation difference analysis from serum samples from a patient (tt) with post-transfusion hepatitis of unknown etiology and designated ttv for transfusion-transmitted virus ... | 1999 | 10719439 |
| sequence heterogeneity of tt virus and closely related viruses. | tt virus (ttv) is a recently discovered infectious agent originally obtained from transfusion-related hepatitis. however, the causative link between the ttv infection and liver disease remains uncertain. recent studies demonstrated that genome sequences of different ttv strains are significantly divergent. to assess genetic heterogeneity of the ttv genome in more detail, a sequence analysis of pcr fragments (271 bp) amplified from open reading frame 1 (orf1) was performed. pcr fragments were amp ... | 2000 | 10708413 |
| prevalence and route of transmission of infection with a novel dna virus (ttv), hepatitis c virus, and hepatitis g virus in patients infected with hiv. | to evaluate the prevalence, route of transmission and clinical significance that current co-infection with tt virus (ttv), hepatitis c virus (hcv), and hepatitis g virus (hgv) have in hiv-1-infected patients. | 2000 | 10708061 |
| prevalence and risk factor analysis of ttv infection in prostitutes. | ttv, a dna virus, has been isolated from patients with non-a to non-e post-transfusion hepatitis. in the past it was assumed that ttv was transmitted parenterally. it is unclear whether sexual contact leads to transmission of this virus. in this study, two sets of ttv-specific polymerase chain reaction primers were used to detect serum ttv dna in 140 prostitutes and 136 controls. the prevalence of ttv dna in prostitutes was significantly higher than in the control group (46/140 [32.9%] vs. 29/13 ... | 2000 | 10686021 |
| prevalence of tt viral dna in italian blood donors with and without elevated serum alt levels: molecular characterization of viral dna isolates. | a novel non-enveloped dna virus, called tt virus (ttv), has been reported to be associated with post-transfusion hepatitis of unknown etiology. although its clinical role still remains obscure, its presence in blood donations might cause problems. it, therefore, appeared of interest to investigate ttv prevalence in voluntary blood donors. | 2000 | 10681726 |
| tt virus and hepatitis g virus infections in korean blood donors and patients with chronic liver disease. | to determine the prevalences of ttv and hgv infections among blood donors and patients with chronic liver disease in korea, to investigate the association of ttv and hgv infections with blood transfusion, and to assess the correlation between ttv and hgv viremia and hepatic damage. | 2003 | 12679923 |
| [infection of tt virus]. | | 2003 | 12722224 |
| prevalence of hepatitis viral infection in dental patients with impacted teeth or jaw deformities. | the prevalence of infection with hepatitis b virus (hbv), hepatitis c virus (hcv), hepatitis g virus (hgv), and transfusion-transmitted viruses (ttv) was evaluated in patients with impacted teeth or jaw deformities. | 2003 | 12847440 |
| epidemiology of viral hepatitis in the mediterranean basin. | the prevalence of viral hepatitis is high and remains a serious public health challenge throughout the world. new molecular biology techniques provided a better understanding of the viruses over the last decades. novel therapeutic options seem to be promising but preventing measures including donor screening, immunization against hepatitis a virus (hav) and hepatitis b virus (hbv), universal use of disposable syringes and implementation of better hygienic conditions play a major role in the cont ... | 2003 | 14737935 |
| sen virus infection--a new hepatitis virus: a review. | approximately 10% of transfusion associated hepatitis and 20% of community acquired hepatitis cases do not have a defined etiology, suggesting the existence of an additional causative agent. the recent agents which have been detected in blood were hepatitis g virus (hgv) and tt virus (ttv), members of the family circoviridae. these viruses were initially thought to be associated with post-transfusion hepatitis but later studies negated this causal effect. recently, a novel dna virus at the momen ... | 2003 | 15022932 |
| tt virus (ttv) genotypes in native and non-native prostitutes of irian jaya, indonesia: implication for non-occupational transmission. | we investigated prostitutes in irian jaya, an indonesian territory of new guinea, to know whether tt virus (ttv) is sexually transmitted and what genotypes of ttv exist there. an orf2 region of the ttv genome was analyzed for 44 isolates from prostitutes (19 were irian jaya natives but 25 were immigrants from java or other islands of indonesia) and 26 isolates from women of child-bearing age in surabaya as a control. the wx(7)hx(3)cx(1)cx(5)h motif sequence of the orf2 was compared across the 70 ... | 2000 | 10664406 |
| molecular characterization of porcine tt virus, an orphan virus, in pigs from six different countries. | human tt virus (ttv), originally isolated from a patient with post-transfusion hepatitis in 1997, is ubiquitous and non-pathogenic. viruses related to human ttv have since been identified in non-human primates, bovine, ovine, porcine, feline, and canine. the objective of this study was to genetically characterize porcine ttv from pigs in different geographic regions. pcr primers based on the non-coding region of the only available porcine ttv isolate were designed to amplify porcine ttv dna from ... | 2004 | 15530745 |
| virus target cell conditioning model to explain some epidemiologic characteristics of childhood leukemias and lymphomas. | frequent infections in early childhood, whole-day care and a socially unprivileged environment have been reported as protective factors for childhood leukemias and lymphomas. conversely, a protected social environment, higher level of education and growing up in families with a low number of children are considered as risk factors. additional risk factors involve agricultural occupation of the parents and exposure to several other occupational factors. these data led to a number of hypotheses th ... | 2005 | 15688417 |
| tt virus infection among egyptian patients with hepatocellular carcinoma. | hepatitis b and c viruses (hbv and hcv) have been associated with hepatocellular carcinoma (hcc). recently, a novel dna virus was isolated from a patient with posttransfusion hepatitis of unknown etiology and designated tt virus (ttv). to examine whether this virus is associated with hcc, we investigated sera from 82 egyptian patients with histopathologically-diagnosed hcc. all subjects underwent serological investigations for detection of hepatitis b surface antigen (hbsag), hepatitis b core an ... | 2003 | 15719618 |
| rolling-circle amplification of torque teno virus (ttv) complete genomes from human and swine sera and identification of a novel swine ttv genogroup. | multiply primed rolling-circle amplification is a novel technology that uses bacteriophage phi29 dna polymerase to amplify circular dna molecules, without the need for prior knowledge of their sequences. in an attempt to detect torque teno virus (ttv), rolling-circle amplification was used to amplify dna extracted from eight human and four pig serum samples. all samples gave high molecular weight (>30 kb) amplification products. by restriction endonuclease digestion, these products generated dna ... | 2005 | 15831945 |
| tt virus infection and pancreatic cancer: relationship or accidental coexistence. | tt virus (ttv) was first isolated in 1997 from the patient with acute post-transfusion hepatitis. this fact led to the conclusion that the virus was hepatotropic and could be one of the causative agents of acute hepatitis. afterwards, however, the virus was found in other human tissues and serological studies revealed that it was widespread. multiple tropisms of ttv and the fact of its high incidence in general population are considered to indicate no medical significance of ttv in human patholo ... | 2005 | 15884138 |
| prevalence and genotypic distribution of hepatitis gb-c/hg and tt viruses in blood donors, mentally retarded children and four groups of patients in eastern anatolia, turkey. | we investigated the prevalence and genotypic distribution of gb virus-c/hepatitis g virus (gbv-c/hgv) and tt virus (ttv) in blood donors, mentally retarded children and four groups of patients living in eastern anatolia, turkey. the prevalence and genetic analysis of ttv were determined by using the primers of the utr and orf1 regions of ttv, respectively. reverse transcription nested (rt-n)-pcr was used to amplify 5' utr of gbv-c/hgv. genotyping of hgv was carried out by pcr-based genotyping as ... | 2005 | 16116255 |
| tt virus (ttv)--etiologic agent of acute hepatitis? | tt virus (ttv) was first isolated in 1997 from the patient with acute posttransfusion hepatitis. this fact led to the conclusion the virus was hepatotropic and could be considered as one of causative agents of acute hepatitis. however, later it was found in other human tissues and serological studies have revealed it is widespread. multiple tropisms of ttv and the fact the virus is found in high rate of general population, are considered arguments for lack of medical significance of ttv in human ... | 2004 | 16146144 |
| transfusion transmitted virus: a review on its molecular characteristics and role in medicine. | the present review gives an updated overview of transfusion transmitted virus (ttv), a novel agent, in relation to its molecular characteristics, epidemiological features, modes of transmission, tissue tropism, pathogenesis, role in various diseases and its eradication from the body. ttv, a dna virus, is a single stranded, non-enveloped, 3.8 kb long dna virus with a small and covalently closed circular genome comprising 3852 bases. it was tentatively designated circinoviridae virus. ttv genome s ... | 2006 | 16937521 |
| genetic relationship of torque teno virus (ttv) between humans and camels in united arab emirates (uae). | torque teno virus (ttv) species-cross infection has been documented. however, the genetic relationship between human and animal ttv remains uncertain. in this study, genotypic characterization of ttv in different camel specimens from the united arab emirates (uae) was undertaken for comparison with human uae ttv. a total of 56 specimens: 34 sera, 14 raw, and 8 pasteurized milk samples were tested for ttv. the results showed that the rate of infection was, 38.2% (13/34), 35.7% (5/14), and 100% (8 ... | 2007 | 17177296 |
| tt virus infection: role of interferons, interleukin-28 and 29, cytokines and antiviral proteins. | in 1997 a novel virus in the serum of a patient with acute post-transfusion hepatitis of non a-g etiology was identified. this agent was designed tt virus (ttv). it produces persistent viremia and no disease, but the mechanism of its persistence is poorly understood. in the present study mrna expression of antiviral proteins as mxa, 2' 5' oas, anti-apopotic protein, cytokines il- 28, il- 29 and ifn are examined in a subject affected by b lymphoma and positive for ttv dna and rna in this cellular ... | 2007 | 17624237 |
| unraveling the puzzle of human anellovirus infections by comparison with avian infections with the chicken anemia virus. | current clinical studies on human annelloviruses infections are directed towards finding an associated disease. in this review we have emphasized the many similarities between human anellovirus and avian circoviruses and the cell and tissue types infected by these pathogens. we have done this in order to explore whether knowledge acquired from natural and experimental avian infections could reflect and be extrapolated to the less well-characterized human annellovirus infections. the knowledge ga ... | 2008 | 18656506 |
| expression of all six human torque teno virus (ttv) proteins in bacteria and in insect cells, and analysis of their igg responses. | torque teno virus (ttv) is a non-enveloped human virus with a circular ( approximately 3800 nt) ssdna genome. ttv transcription results in three viral mrnas and six proteins, the function or antigenicity of which are unknown. the six open reading frames of ttv genotype 6 were expressed in bacteria and insect cells. expression of the orf1/1-encoded protein was inefficient, while expression of the others was successful, with orf1 and orf1/2 as arginine-rich region depleted. all six recombinant ttv ... | 2008 | 18947848 |
| replication of chicken anemia virus (cav) requires apoptin and is complemented by vp3 of human torque teno virus (ttv). | to test requirement for apoptin in the replication of chicken anemia virus (cav), an apoptin-knockout clone, pcav/ap(-), was constructed. dna replication was completely abolished in cells transfected with replicative form of cav/ap(-). a reverse mutant competent in apoptin production regained the full level of dna replication. dna replication and virus-like particle (vlp) production of cav/ap(-) was fully complemented by supplementation of the wild-type apoptin. the virus yield of a point mutant ... | 2009 | 19091368 |
| potential triggers of ms. | ms is an immune mediated disease of the central nervous system (cns) characterized by demyelination, axonal damage and neurologic disability. the primary cause of this cns disease remains elusive. here we will address our current understanding of the role of viruses as potential environmental triggers for ms. virus infections can act peripherally (outside the cns) or within the cns. the association of viral infections with demyelinating disease, in both animals and humans, will be discussed, as ... | 2010 | 19130026 |
| genotypes of tt virus (ttv) compared between liver disease patients and healthy individuals using a new pcr system capable of differentiating 1a and 1b types from others*. | tt virus (ttv) lacks obvious pathogenicity; almost all of the infected hosts are symptom-free. a possibility remains, however, that certain strains can cause liver disease while most others are non-pathogenic. genotypes 1 a and 1 b have been proposed to contain such pathogenic strains. to test this possibility, we constructed a pcr system capable of detecting ttv of the 1 a and 1 b genotypes differentially from the other genotypes, and compared the frequencies of these genotypes between patients ... | 1999 | 10664388 |
| environmental survey to assess viral contamination of air and surfaces in hospital settings. | the presence of pathogenic viruses in healthcare settings represents a serious risk for both staff and patients. direct viral detection in the environment poses significant technical problems and the indirect indicators currently in use suffer from serious limitations. the aim of this study was to monitor surfaces and air in hospital settings to reveal the presence of hepatitis c virus, human adenovirus, norovirus, human rotavirus and torque teno virus by nucleic acid assays, in parallel with me ... | 2011 | 21277649 |
| hepatitis associated aplastic anemia: a review. | hepatitis-associated aplastic anemia (haaa) is an uncommon but distinct variant of aplastic anemia in which pancytopenia appears two to three months after an acute attack of hepatitis. haaa occurs most frequently in young male children and is lethal if leave untreated. the etiology of this syndrome is proposed to be attributed to various hepatitis and non hepatitis viruses. several hepatitis viruses such as hav, hbv, hcv, hdv, hev and hgv have been associated with this set of symptoms. viruses o ... | 2011 | 21352606 |
| host and viral traits predict zoonotic spillover from mammals. | the majority of human emerging infectious diseases are zoonotic, with viruses that originate in wild mammals of particular concern (for example, hiv, ebola and sars). understanding patterns of viral diversity in wildlife and determinants of successful cross-species transmission, or spillover, are therefore key goals for pandemic surveillance programs. however, few analytical tools exist to identify which host species are likely to harbour the next human virus, or which viruses can cross species ... | 2017 | 28636590 |
| [tt virus: a new hepatitis virus?]. | | 1999 | 10617830 |
| methods and conclusions in the clinical study of tt virus. | | 1999 | 10576991 |
| effect of interferon on a nonenveloped dna virus (tt virus) associated with acute and chronic hepatitis of unknown etiology. | an unenveloped dna virus named tt virus (ttv) has been reported in association with acute and chronic hepatitis of unknown etiology. the effect of interferon on ttv was evaluated in the patients with chronic hepatitis c who were coinfected with ttv. ttv dna was determined by a polymerase chain reaction with heminested primers in the 96 patients with chronic hepatitis c who received interferon-alpha (516 million units in 26 weeks) and followed for 24 months thereafter. ttv dna was detected in 31 ... | 1999 | 10447412 |
| tt virus sequence heterogeneity in vivo: evidence for co-infection with multiple genetic types. | tt virus (ttv) is a newly described dna virus of humans that exhibits an unusually high degree of genetic heterogeneity. we have performed extensive analysis of the ttv populations present in samples, taken over a period of 2 to 6 years, from three individuals with persistent ttv infection. ttv dna titres estimated for sequential samples were found to be quite stable over the entire study period in two patients, but fluctuated considerably in the third. dna sequence analysis revealed different g ... | 1999 | 10423145 |
| [genoepidemiology and pathogenicity of tt virus in japanese men with history of intravenous drug abuse and tattoo]. | blood contamination has been proposed as ttv transmission. we studied the genoprevalence of ttv in japanese men with history of intravenous drug abuse and/or tattoo. ttv was identified in serum by a polymerase chain reaction. ttv was detected in 89.7 percent of the men with history of intravenous drug abuse and/or tattoo, 74.4 percent of chronic hepatitis c patients, 78.0 percent of the chronic hepatitis b, and 65.8 percent of chronic hepatitis nonb nonc patients. serum alt levels of those infec ... | 1999 | 10391013 |
| [seroepidemiological survey of tt virus (ttv) infection in an endemic area for hepatitis c virus]. | seroepidemiological survey of tt virus (ttv) infection was performed in the inhabitants living in an endemic area for hepatitis c virus (hcv) in gifu prefecture, japan. in this area, 482 of 1062 inhabitants (45.4%) were seropositive for hcv relative antibodies. ttv-dna was detected in the sera from 12 of 88 inhabitants (13.6%). the positive rate of ttv-dna had no relation to sex or age. the ttv dna-positive rate of the inhabitants with hcv infection was 21.4% higher than that of the inhabitants ... | 1999 | 10391007 |
| [virological response to interferon therapy in patients dually infected with tt virus and hepatitis c virus]. | in 30 chronic hepatitis c patients co-infected with ttv, ttv dna in the sera immediately after cessation of ifn and 6 months after the end of ifn was examined. sustained loss of ttv dna was observed in 12 of 30 (40.0%) patients. in 7 of 30 (23.3%) patients, ttv dna re-appeared 6 months after becoming undetectable at the end of ifn therapy. in the remaining 11 patients (36.7%), ttv dna remained detectable during the entire follow-up period. the alt values correlated only with the presence of hcv ... | 1999 | 10391004 |
| [clinical feature of ttv-related hepatitis]. | it has been clarified that hepatitis g/gb virus-c is the minor cause of acute and chronic non-a-e hepatitis. but there exist non-a-e viral hepatitis patients. recently, one of non-a-e hepatitis associated virus was identified and the new virus was named tt virus. we highly detected tt virus in the serum of hepatitis patients. tt virus were reported to be detected 1-37% of the general population in the world. tt virus may account for only a minor part of acute non-a-e hepatitis in japan. however, ... | 1999 | 10390993 |
| [detection of tt virus in healthy volunteer]. | a novel dna virus, tt virus(ttv), has been reported in japanese patient with non a to g posttransfusion hepatitis. we sought to determine whether ttv infection occurs in healthy volunteer, and to compared with dna extraction methods and polymerase chain reaction(pcr) primer for ttv in diagnostic system. using a nested pcr assay, serum sample of healthy volunteer serve our laboratory in japan were examined for the presence of ttv dna. twenty of 90(22%) healthy volunteer were detected to have ttv ... | 1999 | 10390987 |
| the entire nucleotide sequence of a tt virus isolate from the united states (tus01): comparison with reported isolates and phylogenetic analysis. | a nonenveloped and single-stranded dna virus designated tt virus (ttv) has been reported from japan in association with hepatitis of unknown etiology. very recently, the prototype ttv isolate (ta278) of genotype 1 is proven to have a circular genome with 3852 nucleotides. a ttv isolate (tus01) was recovered from a blood donor in the united states, and its entire circular nucleotide sequence of 3818 nucleotides was determined. it possessed two open reading frames coding for 761 and 156 amino acid ... | 1999 | 10388667 |
| [detection of positive-strand of transfusion transmitted virus fragment in the liver of cryptogenic hepatitis]. | to evaluate whether transfusion transmitted virus (ttv) replicates in the liver and to analyze the relationship between ttv and cryptogenic hepatitis. | 2001 | 11509147 |
| tt virus in hematological disorders and bone marrow transplant recipients. | tt virus (ttv) was cloned as a possible causative agent for non a to c posttransfusion hepatitis. determination of the entire sequence of the virus revealed that the virus is the first human circovirus. the nucleotide sequence of ttv has a wide range of diversity and at least sixteen genotypes have been discovered to date. the prevalence of ttv infection in the normal population differs among countries, but exceeds 10% in several countries. most of ttv infections are not associated with hepatiti ... | 2001 | 11426521 |
| tt virus infection in screened taiwanese blood donors. | tt virus (ttv) is a newly discovered human dna virus of uncertain clinical significance. the aim of this study was to determine the prevalence of ttv infection among blood donors in taiwan. | 2000 | 11155069 |
| epidemiology, prevention and treatment of viral hepatitis with emphasis on new developments. | there are a large number of viruses, such as cytomegalovirus, epstein-barr, herpes simplex, mumps, varicella, yellow fever, etc., known to cause inflammatory disease of the liver, but the term viral hepatitis generally refers to the five well described hepatotropic viruses which are divided into enteral and parenteral groups based on their mode of transmission. hepatitis a and e viruses are enterically transmitted by the faecal-oral route and do not exist in a chronic carrier state. hepatitis b, ... | 2000 | 11144885 |
| molecular epidemiology of tt virus in italy and phylogenesis of viral isolates from subjects at different risk for parenteral exposure. | the prevalence and genotype distribution of human tt virus (ttv) in italy were analysed in 593 subjects at different risk of parenteral infection who included blood donors, patients with chronic type c hepatitis (hcv), thalassemic patients, patients on haemodialysis, human immunodeficiency virus type 1 (hiv-1)-negative intravenous drug users (ivdus), and hiv-1-infected subjects (ivdus, heterosexual contacts and homosexual males). plasma ttv-dna was detected using nested pcr with primers deduced ... | 2001 | 11130892 |
| are hepatitis g virus and tt virus involved in cryptogenic chronic liver disease? | hepatitis g virus can cause chronic infection in man but the role of this agent in chronic liver disease is poorly understood. little is known about the relation of another newly discovered agent, the tt virus, with chronic liver disease. | 2002 | 11926574 |
| prevalence of tt virus in a capd population. | tt virus (ttv) has recently been identified in patients with post-transfusion non-a, non-g hepatitis. it is reported to be common in patients with a variety of liver diseases and with history of transfusion. its pathogenesis in chronic liver diseases remains unclear. in this study, we have determined the prevalence of ttv in a continuous ambulatory peritoneal dialysis (capd) population and related its prevalence with history of previous hemodialysis, transfusion, hcv positivity and serum alanine ... | 2002 | 12053078 |
| weak association between sen virus viremia and liver disease. | recently, a novel dna virus designated sen virus (sen-v), which is thought to be related to posttransfusion hepatitis, was discovered. the aim of the present study was to clarify the relationship between sen-v infection and the development of liver disease. we examined sen-v from the sera of 21 patients with non-b, non-c hepatocellular carcinoma (hcc) and 13 patients with non-b, non-c chronic liver disease (cld) without hcc who were admitted to our hospital between 1995 and 1997. thirty-two pati ... | 2002 | 12202544 |
| nucleic acid testing for emerging viral infections. | the development of new technologies leads to the discovery of new viruses. for each of these new infectious agents, relevance to transfusion, including transmissibility by transfusion, pathogenicity, prevalence in blood donors, persistence and the availability of screening assays needs to be assessed. since 1995, one virus and a new family of viruses have been identified. gb virus-c/hepatitis g virus (gbv-c/hgv), a flavi virus with some homology with and epidemiological features of hcv, is not r ... | 2002 | 12220257 |
| hepatitis g virus (hgv): current perspectives. | five viruses are usually associated with hepatitis in humans: a-e. in addition to these viruses as aetiological agents of hepatitis, there remain a number of patients with hepatitis in whom no virus could be identified. it was therefore postulated that there may be other agents which may be causing hepatitis. recently, two viruses have been associated with hepatitis: hepatitis g virus (hgv), and transfusion transmissible virus (ttv). hepatitis g virus (hgv) is a single stranded rna virus which r ... | 2002 | 12593580 |
| [virus isolated in the human blood leukocyte culture and its interaction with hepatitis c and g viruses]. | electrone-microscopic investigations are indicative of that the cultures of healthy donors, stimulated by phytohemagglutinin (pha), can be successfully used to study the etiology of parenterally transmitted hepatitis. an electronic-microscopic study of a virus, isolated from the blood serum of a patient with hepatitis on the basis of the pha-stimulated human leukocyte cultures and named a hepatitis leukocytic virus (hlv), enabled, by using the negative contrasting method, to detect viral particl ... | 2003 | 12608059 |
| tt virus has a ubiquitous diffusion in human body tissues: analyses of paired serum and tissue samples. | the tissue tropism and possible correlation with liver disease of the tt virus (ttv) as well as its prevalence and genotype distribution remain undefined. ttv-dna was investigated in paired sera and tissue samples from 144 patients, and sera and cerebrospinal fluids (csf) from additional six subjects. of the 144 tissue samples, 128 were liver biopsy specimens from subjects with hepatic disease while 16 were surgically obtained nonliver specimens from patients with extrahepatic disease. ttv cloni ... | 2003 | 12614465 |
| ttv infection in children born to mothers infected with ttv but not with hbv, hcv, or hiv. | the tt virus (ttv) was isolated recently from the serum of a patient with post-transfusion hepatitis. ttv infection is widespread in the general population, and its prevalence increases continuously with age. the pathogenic role of ttv in liver disease remains controversial, and the source of transmission is still unclear. we investigated the pathogenicity and epidemiology of ttv infection in infants born to ttv dna-positive mothers. enrolled in this study were 22 mother-child pairs testing nega ... | 2004 | 15368510 |
| non-alcoholic steatohepatitis (nash) and oral lichen planus: a rare occurrence. | oral lichen planus (olp) is frequently associated with hepatitis c virus infection but uncommonly with other causes of liver disorder. the authors report the case of a 41-year-old male patient with a clinical and histological diagnosis of olp who presented with a marked alteration of the transaminase values, with no signs of past or present hbv, hcv, hgv or ttv infection. the patient did not consume alcohol and no exposure to hepatotoxic substances was reported. all autoantibodies were negative. ... | 2010 | 21146362 |