the e6e7 oncoproteins of cutaneous human papillomavirus type 38 interfere with the interferon pathway.non-melanoma skin cancer is the most frequent malignancy in caucasian populations. evidence suggests the involvement of cutaneous human papillomavirus (hpv) of the genus beta (beta) in this disease. the ability of e6 and e7 of mucosal hpv to promote cellular transformation and inhibit immune response-related pathways plays a key role in cervical carcinogenesis. beta hpv-38 e6 and e7 display transforming activities in in vitro and in vivo models, but their impact on immune surveillance is unknown ...200818519144
subtype hpv38b[fa125] demonstrates heterogeneity of human papillomavirus type 38.the human papillomaviruses (hpvs) exist as more than 100 distinct types. while variants of hpv are common, only few hpv subtypes have been reported. hpv type 38 has been proposed to be associated with nonmelanoma skin cancer (nmsc), with reported prevalences of up to 55%. a subtype of hpv38 was cloned, completely sequenced and found to have a 96% sequence similarity to prototype hpv38 in the l1 open reading frame. the presence of prototype hpv38 and hpv38b[fa125] was examined in paired biopsies ...200616557595
skin hyperproliferation and susceptibility to chemical carcinogenesis in transgenic mice expressing e6 and e7 of human papillomavirus type 38.the oncoproteins e6 and e7 of human papillomavirus type 38 (hpv38) display several transforming activities in vitro, including immortalization of primary human keratinocytes. to evaluate the oncogenic activities of the viral proteins in an in vivo model, we generated transgenic mice expressing hpv38 e6 and e7 under the control of the bovine homologue of the human keratin 10 (k10) promoter. two distinct lines of hpv38 e6/e7-expressing transgenic mice that express the viral genes at different leve ...200516282489
the e6 and e7 proteins of the cutaneous human papillomavirus type 38 display transforming properties.several studies have suggested the involvement of cutaneous human papillomaviruses (hpvs) in the development of nonmelanoma skin cancers. here we have characterized the in vitro properties of e7 proteins of three cutaneous hpv types, 10, 20, and 38, which are frequently detected in skin specimens. we show that hpv38 e7 is able to inactivate the tumor suppressor prb and induces loss of g(1)/s transition control, a key event in carcinogenesis. in contrast, hpv10 and hpv20 e7 proteins do not displa ...200312525654
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