studies of echovirus 5 interactions with the cell surface: heparan sulfate mediates attachment to the host cell.infections caused by echovirus 5 (e5), an enterovirus of the picornaviridae family, have been associated with fever, rashes and sporadic cases of aseptic meningitis. to elucidate the receptor usage of this virus, the significance of a previously proposed integrin binding arginine-glycine-aspartic acid (rgd) motif found in the vp3 capsid protein was investigated, as well as the capacity of e5 to interact with heparan sulfate on the cell surface. using the prototype strain e5 noyce (e5n), an e5n m ...201020466025
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