Publications

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transmission of guanarito and pirital viruses among wild rodents, venezuela.samples from rodents captured on a farm in venezuela in february 1997 were tested for arenavirus, antibody against guanarito virus (gtov), and antibody against pirital virus (pirv). thirty-one (48.4%) of 64 short-tailed cane mice (zygodontomys brevicauda) were infected with gtov, 1 alston's cotton rat (sigmodon alstoni) was infected with gtov, and 36 (64.3%) of 56 other alston's cotton rats were infected with pirv. the results of analyses of field and laboratory data suggested that horizontal tr ...201122172205
host and viral traits predict zoonotic spillover from mammals.the majority of human emerging infectious diseases are zoonotic, with viruses that originate in wild mammals of particular concern (for example, hiv, ebola and sars). understanding patterns of viral diversity in wildlife and determinants of successful cross-species transmission, or spillover, are therefore key goals for pandemic surveillance programs. however, few analytical tools exist to identify which host species are likely to harbour the next human virus, or which viruses can cross species ...201728636590
genetic diversity between and within the arenavirus species indigenous to western venezuela.the results of analyses of z, rna-dependent rna polymerase, glycoprotein precursor, and nucleocapsid protein gene sequence data suggested that guanarito virus was the most common cause of venezuelan hemorrhagic fever in a 7-year period in the 1990s and that the evolution of pirital virus in association with sigmodon alstoni (alston's cotton rat) has occurred at a significantly higher rate than the evolution of guanarito virus in association with zygodontomys brevicauda (short-tailed cane mouse) ...200818586298
experimental infection of neotoma albigula (muridae) with whitewater arroyo virus (arenaviridae).the whitewater arroyo virus (wwa) is a newly described north american arenavirus. the purpose of this study was to elucidate the biology of this virus in its natural rodent host, neotoma albigula (white-throated woodrat). thirteen adult, 7 juvenile, and 8 newborn woodrats each were inoculated subcutaneously with 1,000 cell culture infectious dose50 of the wwa virus prototype strain av 9310135. all 28 animals became infected (as measured by the recovery of infectious virus and/or seroconversion) ...200111508391
experimental infection of the cane mouse zygodontomys brevicauda (family muridae) with guanarito virus (arenaviridae), the etiologic agent of venezuelan hemorrhagic fever.chronic infections in specific rodents appear to be crucial to the long-term persistence of arenaviruses in nature. the cane mouse, zygodontomys brevicauda, is a natural host of guanarito virus (family arenaviridae), the etiologic agent of venezuelan hemorrhagic fever. the purpose of this study was to elucidate the natural history of guanarito virus infection in z. brevicauda. thirty-nine laboratory-reared cane mice each were inoculated subcutaneously with 3.0 log10 plaque-forming units of the g ...199910479119
natural rodent host associations of guanarito and pirital viruses (family arenaviridae) in central venezuela.the objective of this study was to elucidate the natural rodent host relationships of guanarito and pirital viruses (family arenaviridae) in the plains of central venezuela. ninety-two arenavirus isolates from 607 animals, representing 10 different rodent species, were characterized to the level of serotype. the 92 isolates comprised 19 guanarito virus strains and 73 pirital virus strains. the 19 guanarito virus isolates were from zygodontomys brevicauda; 72 (98.6%) of the 73 pirital virus isola ...199910463688
isolation and characterization of pirital virus, a newly discovered south american arenavirus.specific rodent species are principal hosts for each of the well-characterized members of the virus family arenaviridae. guanarito virus (arenaviridae) is the etiologic agent of venezuelan hemorrhagic fever. a previous study on the epidemiology of venezuelan hemorrhagic fever revealed extensive arenavirus infection (presumed to be caused by guanarito virus) in two rodent species. sigmodon alstoni and zygodontomys brevicauda, collected from the region of venezuela in which the disease is endemic. ...19979180606
field studies on the epidemiology of venezuelan hemorrhagic fever: implication of the cotton rat sigmodon alstoni as the probable rodent reservoir.during february 1992, field studies on the epidemiology of venezuelan hemorrhagic fever (vhf) were carried out in a rural area of portuguesa state in central venezuela. the objective of this work was to determine the prevalence of infection with guanarito virus, the etiologic agent of vhf, among wild rodents and humans living within an endemic focus of the disease. a total of 234 rodents, representing nine different species, were collected and their spleens were cultured for virus. thirty-one gu ...19938395143
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