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characterization and distribution of the gene cluster encoding rumc, an anti-clostridium perfringens bacteriocin produced in the gut.ruminococcin c (rumc) is a trypsin-dependent bacteriocin produced by ruminococcus gnavus e1, a gram-positive strict anaerobic strain isolated from human feces. it consists of at least three similar peptides active against clostridium perfringens. in this article, a 15-kb region from r. gnavus e1 chromosome, containing the biosynthetic gene cluster of rumc was characterized. it harbored 17 open reading frames (called rum(c) genes) with predicted functions in bacteriocin biosynthesis and post-tran ...201122092178
distribution of genes encoding the trypsin-dependent lantibiotic ruminococcin a among bacteria isolated from human fecal microbiota.fourteen bacterial strains capable of producing a trypsin-dependent antimicrobial substance active against clostridium perfringens were isolated from human fecal samples of various origins (from healthy adults and children, as well as from adults with chronic pouchitis). identification of these strains showed that they belonged to ruminococcus gnavus, clostridium nexile, and ruminococcus hansenii species or to new operational taxonomic units, all from the clostridium coccoides phylogenetic group ...200212089024
α-galactosidase/sucrose kinase (agask), a novel bifunctional enzyme from the human microbiome coupling galactosidase and kinase activities.α-galactosides are non-digestible carbohydrates widely distributed in plants. they are a potential source of energy in our daily food, and their assimilation by microbiota may play a role in obesity. in the intestinal tract, they are degraded by microbial glycosidases, which are often modular enzymes with catalytic domains linked to carbohydrate-binding modules. here we introduce a bifunctional enzyme from the human intestinal bacterium ruminococcus gnavus e1, α-galactosidase/sucrose kinase (aga ...201121931163
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