| pathogenesis and vertical transmission of a transplacental rat cytomegalovirus. | cytomegalovirus (cmv) congenital infection is the major viral cause of well-documented birth defects in human. because cmv is species-specific, the main obstacle to developing animal models for congenital infection is the difference in placental architecture, which preludes virus transmission across the placenta. the rat placenta, resembling histologically to that of human, could therefore facilitate the study of cmv congenital infection in human. | 2006 | 16737550 |
| identification of novel rodent herpesviruses, including the first gammaherpesvirus of mus musculus. | rodent herpesviruses such as murine cytomegalovirus (host, mus musculus), rat cytomegalovirus (host, rattus norvegicus), and murine gammaherpesvirus 68 (hosts, apodemus species) are important tools for the experimental study of human herpesvirus diseases. however, alphaherpesviruses, roseoloviruses, and lymphocryptoviruses, as well as rhadinoviruses, that naturally infect mus musculus (house mouse) and other old world mice are unknown. to identify hitherto-unknown rodent-associated herpesviruses ... | 2007 | 17507487 |
| host and viral traits predict zoonotic spillover from mammals. | the majority of human emerging infectious diseases are zoonotic, with viruses that originate in wild mammals of particular concern (for example, hiv, ebola and sars). understanding patterns of viral diversity in wildlife and determinants of successful cross-species transmission, or spillover, are therefore key goals for pandemic surveillance programs. however, few analytical tools exist to identify which host species are likely to harbour the next human virus, or which viruses can cross species ... | 2017 | 28636590 |
| isolates of cytomegalovirus (cmv) from the black rat rattus rattus form a distinct group of rat cmv. | two different betaherpesviruses, the english and maastricht species of rat cytomegalovirus (cmv), have previously been isolated from rattus norvegicus. cmvs were isolated from both the brown rat, r. norvegicus, and the black rat, r. rattus, within australia. the viruses isolated from r. norvegicus appeared to be genetically related to the english species of rat cmv by pcr, rflp, and sequencing, but the viruses isolated from r. rattus were distinct from both prototype virus species, although more ... | 2004 | 15105548 |
| characterization of a novel rat cytomegalovirus (rcmv) infecting placenta-uterus of rattus rattus diardii. | a new rat cytomegalovirus (rcmv) isolated from the placenta/uterus of a house rat (rattus rattus diardii) was found to productively infect rat embryo fibroblast (ref) cells. the virus produced typical herpesvirus-like cytopathic effects characterized by a lytic infection. the well-known herpesvirus morphology was confirmed by electron microscopy. its slow growth in cell culture indicated that the virus is belonging to subfamily betaherpesvirinae. electron microscopy techniques and immunohistoche ... | 2003 | 14648291 |
| potential detrimental effects of rodent viral infections on long-term experiments. | healthy animals are of paramount importance in obtaining meaningful, reliable scientific results. viral infections of rodents often have a significant impact on various types of biomedical research. laboratory animal specialists and researchers must be aware of the possible consequences associated with the use of infected animals. the objective of the paper is a discussion of the frequently encountered viral infections that can complicate or invalidate the interpretation of results by altering t ... | 1988 | 2847406 |
| identification and comparison of rcmv all 03 open reading frame (orf) among several different strains of cytomegalovirus worldwide. | rat cytomegalovirus all-03 (malaysian strain) which was isolated from a placenta and uterus of a house rat, rattus rattus diardii has the ability to cross the placenta and infecting the fetus. to further elucidate the pathogenesis of the malaysian strain of rat cytomegalovirus all-03 (rcmv all-03), detailed analysis on the viral genome sequence is crucial. | 2017 | 28642159 |