| herpesvirus saimiri has a gene specifying a homologue of the cellular membrane glycoprotein cd59. | herpesvirus saimiri (hsv) is a t-lymphotropic tumor virus that causes fulminant lymphomas and leukemias in various new world primates other than its natural host, the squirrel monkey (saimiri sciureus). in the course of completing the nucleotide sequence of its genome, we identified an open reading frame of 363 nucleotides, designated hvs-15, that has no detectable homology to any other viral sequences to date. hvs-15 encodes a 121-amino-acid protein which shows significant similarities to human ... | 1992 | 1382344 |
| isolation of herpesvirus saimiri from blood of squirrel monkeys (saimiri sciureus). | | 1972 | 4337913 |
| [lymphocyte heterogeneity of the t system: characterization of an allotypic antiserum recognizing a sub-species antigenic determinant in non-human primates]. | to determine the membrane properties in t-lymphocyte population from saguinus primates or lymphoblastoid cell lines of the same origin, an allotypic antiserum was prepared inoculating two saguinus illigeri with 3.5 x 10(10) viable 70n2 cells obtained in-vitro, from a lymphoma induced by inoculation of herpesvirus saimiri in a saguinus oedipus. the 70n2 cells carried the virus genome in an episomal way; it did not produce infectious virus and it formed spontaneous rosettes (99%) with sheep erythr ... | 1982 | 6086023 |
| immunoprecipitation as a tool for studying humoral immunity of natural and experimental hosts of herpesvirus saimiri. | herpesvirus saimiri strain 11 and attenuated h. saimiri strain 11 proteins synthesized during the lytic cycle of virus replication were used for immunoprecipitation with various sera from natural (saimiri sciureus) and experimental (saguinus nigricollis, saguinus fuscicollis, aotus trivirgatus, new zealand white rabbits) hosts. the analysis of the precipitates separated in sodium dodecyl sulfate:polyacrylamide gels revealed that in tumor-developing animals a specific set of viral polypeptides we ... | 1983 | 6303583 |
| host and viral traits predict zoonotic spillover from mammals. | the majority of human emerging infectious diseases are zoonotic, with viruses that originate in wild mammals of particular concern (for example, hiv, ebola and sars). understanding patterns of viral diversity in wildlife and determinants of successful cross-species transmission, or spillover, are therefore key goals for pandemic surveillance programs. however, few analytical tools exist to identify which host species are likely to harbour the next human virus, or which viruses can cross species ... | 2017 | 28636590 |
| a region of the herpesvirus saimiri genome required for oncogenicity. | herpesvirus saimiri naturally infects squirrel monkeys (saimiri sciureus) without producing signs of disease; infection of other new world primates, however, results in a rapidly progressing, malignant, t-cell lymphoma. results described in this report identify a region of the viral genome that is required for oncogenicity in owl monkeys (aotus trivirgatus); this region is not required for replication of the virus. this is believed to be the first such genomic region identified in a herpesvirus ... | 1985 | 2983431 |
| herpesvirus saimiri encodes homologues of g protein-coupled receptors and cyclins. | herpesvirus saimiri (hvs) is a t-lymphotropic gammaherpesvirus which establishes asymptomatic infections in its natural host the squirrel monkey (saimiri sciureus), but which causes fatal lymphoproliferative diseases in other new world primates. sequencing studies show hvs is closely related to the human b-lymphotropic gammaherpesvirus epstein-barr virus (ebv). however, despite the general colinearity between the genomes of hvs and ebv, hvs contains genes not found in ebv or in the genomes of an ... | 1992 | 1309943 |
| squirrel monkey retrovirus and herpesvirus saimiri: observation in the same cell following isolation. | electron microscopic examination of mink lung cells previously cultured with a squirrel monkey (saimiri sciureus) throat swab suspension revealed the presence of squirrel monkey retrovirus (smrv) and herpesvirus saimiri (hvs) coexisting within the same cells in culture. hvs was identified by serum neutralization, and the retrovirus isolate was identified as smrv by a morphologic examination, microimmunodiffusion analysis, and demonstration of an mg2+ preference for the rna-directed dna polymeras ... | 1979 | 225504 |
| herpesvirus saimiri episomal persistence is maintained via interaction between open reading frame 73 and the cellular chromosome-associated protein mecp2. | herpesvirus saimiri (hvs) is the prototype gamma-2 herpesvirus, which naturally infects the squirrel monkey saimiri sciureus, causing an asymptomatic but persistent infection. the latent phase of gamma-2 herpesviruses is characterized by their ability to persist in a dividing cell population while expressing a limited subset of latency-associated genes. in hvs only three genes, open reading frame 71 (orf71), orf72, and orf73, are expressed from a polycistronic mrna. orf73 has been shown to be th ... | 2007 | 17267510 |
| t-cell transformation and oncogenesis by gamma2-herpesviruses. | gamma2-herpesviruses, also termed rhadinoviruses, have long been known as animal pathogens causing lymphoproliferative diseases such as malignant catarrhal fever in cattle or t-cell lymphoma in certain neotropical primates. the rhadinovirus prototype is herpesvirus saimiri (hvs), a t-lymphotropic agent of squirrel monkeys (saimiri sciureus); herpesvirus ateles (hva) is closely related to hvs. the first human rhadinovirus, human herpesvirus type 8 (hhv-8), was discovered a decade ago in kaposi's ... | 2005 | 15797445 |
| downregulation of p56(lck) tyrosine kinase activity in t cells of squirrel monkeys (saimiri sciureus) correlates with the nontransforming and apathogenic properties of herpesvirus saimiri in its natural host. | herpesvirus saimiri is capable of transforming t lymphocytes of various primate species to stable growth in culture. the interaction of the t-cellular tyrosine kinase p56(lck) with the transformation-associated viral protein tip has been shown before to activate the kinase and provides one model for the t-cell-specific transformation by herpesvirus saimiri subgroup c strains. in contrast to other primate species, squirrel monkeys (saimiri sciureus) are naturally infected with the virus without s ... | 2001 | 11533187 |
| herpesvirus saimiri. | herpesvirus saimiri (saimiriine herpesvirus 2) is the classical prototype of the gamma(2)-herpesviruses or rhadinoviruses, which also contains a human member, the kaposi's sarcoma-associated herpesvirus. the t-lymphotropic herpesvirus saimiri establishes specific replicative and persistent conditions in different primate host species. virtually all squirrel monkeys (saimiri sciureus) are persistently infected with this virus. in its natural host, the virus does not cause disease, whereas it indu ... | 2001 | 11313011 |
| two distinct gamma-2 herpesviruses in african green monkeys: a second gamma-2 herpesvirus lineage among old world primates? | primate gamma-2 herpesviruses (rhadinoviruses) have so far been found in humans (kaposi's sarcoma-associated herpesvirus [kshv], also called human herpesvirus 8), macaques (macaca spp.) (rhesus rhadinovirus [rrv] and retroperitoneal fibromatosis herpesvirus [rfhv]), squirrel monkeys (saimiri sciureus) (herpesvirus saimiri), and spider monkeys (ateles spp.) (herpesvirus ateles). using serological screening and degenerate consensus primer pcr for the viral dna polymerase gene, we have detected seq ... | 2000 | 10627572 |
| antiviral cell-mediated immune responses and effect of chromosome polymorphism in herpesvirus saimiri-infected monkeys. | herpesvirus saimiri is a horizontally transmitted virus of squirrel monkeys (saimiri sciureus) which, when inoculated into owl monkeys (aotus trivirgatus), induces fatal malignant lymphoma in 75 to 80% of the animals. previous immunological and virological studies have not indicated why 20 to 25% of inoculated owl monkeys develop a chronic, disease-free h. saimiri infection. in the present study, we examined two parameters to explain why certain owl monkeys are resistant to h. saimiri-induced di ... | 1980 | 6247277 |