Publications

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full-length genome characterization of a novel simian immunodeficiency virus lineage (sivolc) from olive colobus (procolobus verus) and new sivwrcpbb strains from western red colobus (piliocolobus badius badius) from the tai forest in ivory coast.simian immunodeficiency viruses (sivs) are found in an extensive number of african primates and humans continue to be exposed to these viruses by hunting and handling of primate bushmeat. full-length genome sequences were obtained from sivs derived from two colobinae species inhabiting the taï forest, ivory coast, each belonging to a different genus: sivwrc from western red colobus (piliocolobus badius badius) (sivwrcpbb-98ci04 and sivwrcpbb-97ci14) and sivolc (sivolc-97ci12) from olive colobus ...200918922864
risk to human health from a plethora of simian immunodeficiency viruses in primate bushmeat.to assess human exposure to simian immunodeficiency virus (siv) in west central africa, we looked for siv infection in 788 monkeys that were hunted in the rainforests of cameroon for bushmeat or kept as pets. serologic reactivity suggesting siv infection was found in 13 of 16 primate species, including 4 not previously known to harbor siv. overall, 131 sera (16.6%) reacted strongly and an additional 34 (4.3%) reacted weakly with hiv antigens. molecular analysis identified five new phylogenetic s ...200211996677
coinfection of ugandan red colobus (procolobus [piliocolobus] rufomitratus tephrosceles) with novel, divergent delta-, lenti-, and spumaretroviruses.nonhuman primates host a plethora of potentially zoonotic microbes, with simian retroviruses receiving heightened attention due to their roles in the origins of human immunodeficiency viruses type 1 (hiv-1) and hiv-2. however, incomplete taxonomic and geographic sampling of potential hosts, especially the african colobines, has left the full range of primate retrovirus diversity unexplored. blood samples collected from 31 wild-living red colobus monkeys (procolobus [piliocolobus] rufomitratus te ...200919692478
characterization of a novel simian immunodeficiency virus (sivmonng1) genome sequence from a mona monkey (cercopithecus mona).a novel simian immunodeficiency virus (siv) sequence has been recovered from rna extracted from the serum of a mona monkey (cercopithecus mona) wild born in nigeria. the sequence was obtained by using novel generic (degenerate) pcr primers and spans from two-thirds into the gag gene to the 3' poly(a) tail of the sivmonng1 rna genome. analysis of the open reading frames revealed that the sivmonng1 genome codes for a vpu protein, in addition to gag, pol, vif, vpr, tat, rev, env, and nef proteins. ...200312768007
partial molecular characterization of two simian immunodeficiency viruses (siv) from african colobids: sivwrc from western red colobus (piliocolobus badius) and sivolc from olive colobus (procolobus verus).in order to study primate lentivirus evolution in the colobinae subfamily, in which only one simian immunodeficiency virus (siv) has been described to date, we screened additional species from the three different genera of african colobus monkeys for siv infection. blood was obtained from 13 west african colobids, and hiv cross-reactive antibodies were observed in 5 of 10 piliocolobus badius, 1 of 2 procolobus verus, and 0 of 1 colobus polykomos specimens. phylogenetic analyses of partial pol se ...200312477880
characterization of a novel simian immunodeficiency virus from guereza colobus monkeys (colobus guereza) in cameroon: a new lineage in the nonhuman primate lentivirus family.exploration of the diversity among primate lentiviruses is necessary to elucidate the origins and evolution of immunodeficiency viruses. during a serological survey in cameroon, we screened 25 wild-born guereza colobus monkeys (colobus guereza) and identified 7 with hiv/siv cross-reactive antibodies. in this study, we describe a novel lentivirus, named sivcol, prevalent in guereza colobus monkeys. genetic analysis revealed that sivcol was very distinct from all other known siv/hiv isolates, with ...200111134299
host and viral traits predict zoonotic spillover from mammals.the majority of human emerging infectious diseases are zoonotic, with viruses that originate in wild mammals of particular concern (for example, hiv, ebola and sars). understanding patterns of viral diversity in wildlife and determinants of successful cross-species transmission, or spillover, are therefore key goals for pandemic surveillance programs. however, few analytical tools exist to identify which host species are likely to harbour the next human virus, or which viruses can cross species ...201728636590
global mammal parasite database version 2.0.illuminating the ecological and evolutionary dynamics of parasites is one of the most pressing issues facing modern science, and is critical for basic science, the global economy, and human health. extremely important to this effort are data on the disease-causing organisms of wild animal hosts (including viruses, bacteria, protozoa, helminths, arthropods, and fungi). here we present an updated version of the global mammal parasite database, a database of the parasites of wild ungulates (artioda ...201728273333
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