| [transfusion-associated non-a, non-b, non-c hepatitis caused by flaviviruses]. | hepatitis c virus was shown to be a member of the flavivirus family. tick-borne encephalitis virus and west nile virus, members of the same family occur in hungary, too. serum samples from patients suffering from transfusion associated hepatitis were tested with yellow fever virus antigens for specific igg, and igm using immunofluorescence test. eight hundred serum samples were tested. yellow fever virus related igg antibodies were found in 232 sera. in the case of 72 patients specific igm antib ... | 1992 | 1321397 |
| [the reproduction of the tick-borne encephalitis virus in human leukocytes]. | | 1991 | 1858359 |
| [use of peroxidase-labeled antigen of tick-borne encephalitis virus for analysis of specific immunoglobulin response and the evaluation of its diagnostic usefulness for detecting the etiological factor of human neurologic infections]. | peroxidase labelled virus of tick-borne encephalitis (k.z.m.) was used for humoral immune response analysis in humans. dot-elisa methods elaborated in a version of "catching antibodies" (cab-elisa) was compared in respect to its diagnostic usefulness to indirect immunoenzymatic method (i-elisa) and to haemagglutination inhibition test (ozha). high sensitivity and diagnostic value of both methods were confirmed. as compared to i-elisa, cab-elisa was characterised by higher specificity of igm anti ... | 1990 | 2087135 |
| [detection of the tick-borne encephalitis virus in human blood and in individual ticks by molecular nucleic acid hybridization]. | | 1986 | 2435064 |
| persistent infection of a human diploid cell strain with tick-borne encephalitis virus. | | 1967 | 4382993 |
| [structure of tick-borne encephalitis virus populations in foci with various levels of morbidity in the human population]. | the results of comparative studies on the structure of viral populations by virulence for white mice inoculated by different routes as well as on the antigenic characteristics of virus strains in two foci of tick-borne encephalitis (tbe) in western siberia differing significantly by the disease incidence rates among the human population and by the "risk of infection" indices are presented. the portion of virus strains with different virulence in the total number of strains (92) studied in both t ... | 1984 | 6464426 |
| [immunological indices of human vaccination against tick-borne encephalitis using inactivated preparations with a varying concentration of the viral antigen]. | the results obtained in the determination of the immunological activity of 3 types of formalin-killed tissue-culture tick-borne encephalitis vaccine, commercial non-concentrated and concentrated by 2 different methods, in humans are presented. judging by the data of 3 serological tests and the blast transformation test, the concentration of killed tick-borne encephalitis virus enhanced immune response to vaccination. the intensity of this response correlated with the mouse protection capacity of ... | 1981 | 7293574 |
| [new properties of trental as an inhibitor of viral activity with a wide range of activity]. | experimental investigations on the spectrum and degree of the expression of trental antiviral activity were carried out. the investigations were done in cell cultures and laboratory animals using laboratory strains (including drug-resistant ones) of 13 viruses, causative agents of human and animal infections. the drug demonstrated its activity against 8 viruses of 7 families. it was highly active against 5 viruses: herpes simplex virus (including its acyclovir-resistant strain), vaccinia virus ( ... | 1993 | 8284924 |
| biology of tick-borne encephalitis virus. | tick-borne encephalitis (tbe) virus is an important human pathogen belonging to the genus flavivirus within the family flaviviridae. the genome of the tbe virus is a single-stranded rna (ssrna) molecule of positive polarity encoding all the viral proteins within a single open reading frame (orf). tbe virus shares common physical and genetic characteristic of the flavivirus genus. two subtypes of the tbe virus have been described: (1) european, endemic in many parts of europe and transmitted by i ... | 1997 | 9219644 |
| acute viral encephalitis in adults--a prospective study. | we have prospectively studied 27 adult patients attending the department of infectious diseases, göteborg, sweden, between october 1992 and october 1996 with a diagnosis of acute viral encephalitis. in addition to cerebrospinal fluid (csf) virus isolations and antibody analyses against herpes simplex virus, cytomegalovirus, varicella zoster virus, epstein-barr virus (ebv), enterovirus, adenovirus, tick-borne encephalitis virus, and mycoplasma, polymerase chain reaction test (pcr) to 5 viruses fr ... | 1998 | 9790126 |
| pcr detection of borrelia burgdorferi sensu lato, tick-borne encephalitis virus, and the human granulocytic ehrlichiosis agent in ixodes persulcatus ticks from western siberia, russia. | pcr assays were used to test adult ixodes persulcatus ticks from western siberia, russia, for borrelia burgdorferi sensu lato, tick-borne encephalitis virus (tbev), and the human granulocytic ehrlichiosis (hge) agent. of the 150 ticks that were studied, 38% were infected with b. burgdorferi, 46% were infected with tbev, and 8% were infected with the hge agent. these three pathogens were distributed in the ticks independently of one another. | 2002 | 12354885 |
| tick-borne encephalitis. | tick-borne encephalitis (tbe) is one of the most dangerous human infections occurring in europe and many parts of asia. the etiological agent tick-borne encephalitis virus (tbev), is a member of the virus genus flavivirus, of the family flaviviridae. tbev is believed to cause at least 11,000 human cases of encephalitis in russia and about 3000 cases in the rest of europe annually. related viruses within the same group, louping ill virus (liv), langat virus (lgtv) and powassan virus (powv), also ... | 2003 | 12615309 |
| uptake of glucose, amino-acids and vitamins by human amnion cell cultures infected with a tick-borne encephalitis virus. | | 1962 | 13903978 |
| mimicking live flavivirus immunization with a noninfectious rna vaccine. | flaviviruses are human pathogens of world-wide medical importance. they have recently received much additional attention because of their spread to new regions (such as west nile virus to north america), highlighting their potential as newly emerging disease agents. using tick-borne encephalitis virus, we have developed and evaluated in mice a new genetic vaccine based on self-replicating but noninfectious rna. this rna contains all of the necessary genetic information for establishing its repli ... | 2004 | 14769933 |
| recent advancement in flavivirus vaccine development. | lately, the magnitude of cumulative diseases burden caused by flaviviruses, such as dengue virus, japanese encephalitis virus, tick-borne encephalitis virus, west nile virus and yellow fever virus, has reached an unprecedented level with the sizes of human and animal populations at risk increasing sharply. these diseases present highly complex medical, economic and ecologic problems, some effecting primarily human and others affecting human, livestock and wildlife. the large body of recent publi ... | 2004 | 15056045 |
| identification of tick-borne encephalitis virus ribonucleic acid in tick suspensions and in clinical specimens by a reverse transcription-nested polymerase chain reaction assay. | tick-borne encephalitis virus (tbev) is a major human pathogenic flavivirus. sensitive assays for the detection of viral rna may be valuable both for the identification of virus in ticks as well as for diagnostic purposes. | 1995 | 15566853 |
| the importance of tick-borne encephalitis virus rna detection for early differential diagnosis of tick-borne encephalitis. | tick-borne encephalitis virus (tbev) is one of the most important causes of human viral infections of the central nervous system in europe. currently, the diagnosis of tbe is based on the demonstration of specific antibodies in patient's serum, which appear only several weeks after the infection. | 2005 | 15919235 |
| etiology of tick-borne febrile illnesses in adult residents of north-eastern poland: report from a prospective clinical study. | febrile tick-borne diseases can be caused by different pathogens. the study objective was to prospectively determine the etiology of infection among adults exposed to tick bite and to detect acute human granulocytic anaplasmosis (hga), a recently emerging infection, in north-eastern poland. we evaluated 68 patients (34 males and 34 females, mean age 44.2+/-15 years) who had fever within 4 weeks after a tick bite. paired sera were tested for antibodies against tick-borne encephalitis virus, borre ... | 2006 | 16530481 |
| mouse and hamster models for the study of therapy against flavivirus infections. | small animal models that are reminiscent of flaviviral disease in human will be instrumental in identifying therapeutic strategies against flavivirus infections. here we review models in mice and hamsters for the most clinically important flaviviruses: dengue virus, yellow fever virus, west nile virus, japanese encephalitis virus and tick-borne encephalitis virus. in addition, models are discussed that employ no known vector viruses such as the modoc virus. these viruses can be manipulated in bs ... | 2006 | 17319165 |
| emerging zoonoses and vector-borne infections affecting humans in europe. | the purpose of this study was to assess and describe the current spectrum of emerging zoonoses between 2000 and 2006 in european countries. a computerized search of the medline database from january 1966 to august 2006 for all zoonotic agents in european countries was performed using specific criteria for emergence. fifteen pathogens were identified as emerging in europe from 2000 to august 2006: rickettsiae spp., anaplasma phagocytophilum, borrelia burgdorferi, bartonella spp., francisella tula ... | 2007 | 17445320 |
| detection strategies of tick-borne encephalitis virus in swedish ixodes ricinus reveal evolutionary characteristics of emerging tick-borne flaviviruses. | the flaviviral tick-borne encephalitis virus (tbev) is a human pathogen having significant impact on public health. the geographical distribution of tbev and tbev-like viruses is increasing, which makes it important to characterise the natural virus populations. here we present four rt-pcr strategies designed for detection of broad types of tick-borne flaviviruses. sequence information on more than 32% of a tbev genome was generated from a small pool of ticks collected in the stockholm archipela ... | 2007 | 17277902 |
| quality control assessment for the pcr diagnosis of tick-borne encephalitis virus infections. | reverse transcriptase-polymerase chain reaction (rt-pcr) is an efficient method for the early detection of tick-borne encephalitis virus (tbev) rna in blood and serum samples taken prior to the appearance of antibodies. improved diagnostics are critical for optimally detecting and managing tbe infections and quality control measures are therefore essential. | 2007 | 17070730 |
| gadolinium enhancement of cauda equina: a new mr imaging finding in the radiculitic form of tick-borne encephalitis. | tick-borne encephalitis virus is an important human pathogen in europe. the infection usually presents as meningitis, meningoencephalitis, or meningoencephalomyelitis and only rarely as symptoms of isolated myeloradiculitis. we describe the lumbar mr imaging finding in a 48-year-old man with serologically confirmed tick-borne encephalitis in which there was enhancement of the ventral surface of the conus and the anterior nerve roots from the t12 level extending along the length of the ventral ca ... | 2006 | 16687530 |
| etiology of aseptic meningitis and encephalitis in an adult population. | to investigate the etiology of aseptic meningitis and encephalitis in an adult population using modern microbiologic methods. | 2006 | 16401850 |
| [climate changes and emerging diseases. what new infectious diseases and health problem can be expected?]. | increasing temperatures, but also other climatic factors, will have an impact on human health. apart from the direct consequences of extreme weather conditions (e.g., heat-related fatalities), indirect health consequences in the long-term are also of great importance. in addition to a likely increase in allergic diseases and additional complications in the course of cardiovascular and respiratory diseases, infectious diseases are of particular interest. in germany, endemic pathogens, such as han ... | 2009 | 19536444 |
| [hepatitis caused by tick-borne meningoencephalitis virus (tbev)--a rare clinical manifestation outside the central nervous system involvement]. | north part of croatia, especially the koprivnica-krizevci county has been a well-known endemic area of tick-borne encephalitis (tbe) for more than 50 years. to date, this disease caused by tick-borne encephalitis virus (tbev) has retained the leading position among inflammatory diseases of the central nervous system (cns), with an average morbidity of 19 patients per year. in 88% of patients the infection manifested with signs of meningitis or meningoencephalitis with a biphasic course. tbe may ... | 2005 | 16334744 |
| visualization of central european tick-borne encephalitis infection in fatal human cases. | central european tick-borne encephalitis (tbe) is caused by a flavivirus vectored by the ixodes ricinus tick. in severe infections, tbe presents as (myelo)meningoencephalitis with considerable mortality. characteristic neuropathologic changes feature a multinodular to patchy polioencephalomyelitis accentuated in spinal cord, brainstem, and cerebellum. visualization of viral infection by immunohistochemistry has not yet been achieved. we analyzed immunohistochemically the distribution of viral an ... | 2005 | 15977642 |
| high-throughput procedure for tick surveys of tick-borne encephalitis virus and its application in a national surveillance study in switzerland. | tick-borne encephalitis (tbe), a viral infection of the central nervous system, is endemic in many eurasian countries. in switzerland, tbe risk areas have been characterized by geographic mapping of clinical cases. since mass vaccination should significantly decrease the number of tbe cases, alternative methods for exposure risk assessment are required. we established a new pcr-based test for the detection of tbe virus (tbev) in ticks. the protocol involves an automated, high-throughput nucleic ... | 2010 | 20453126 |
| tick-borne encephalitis in southern norway. | the first five cases of human tick-borne encephalitis in norway were reported from tromöya, in aust-agder county. serum specimens from 317 dogs in the same geographic area were collected. an enzyme immunoassay demonstrated antibody to human tick-borne encephalitis virus in 52 (16.4%) of the dogs, which supports the notion of an emerging disease. | 2004 | 15109431 |
| characterisation of human tick-borne encephalitis virus from sweden. | viruses of the tick-borne encephalitis (tbe) antigenic complex, within the family flaviviridae, cause a variety of diseases including uncomplicated febrile illness, meningo-encephalitis and haemorrhagic fever. different wildlife species act as reservoir hosts with ixodid tick species as vectors. tbe virus (tbev) causes 40-130 cases confirmed serologically in sweden each year. characteristics of tbev strains circulating in sweden have not been investigated previously and no viral sequence data ha ... | 2003 | 14556277 |
| incidence of antibodies against tick-borne encephalitis virus in man and domestic animals in a small village in a natural focus of infection. | | 1960 | 13761883 |
| occurrence of tbe in areas previously considered being non-endemic: scandinavian data generate an international study by the international scientific working group for tbe (isw-tbe). | tick-borne encephalitis virus (tbev) has been endemic in many countries in central, northern and eastern europe. more than 3000 human cases are reported annually, the baltic states included. tbev causes cns infections presented as meningitis or meningoencephalitis with or without myelitis. the case fatality rate in europe is approximately 0.5%, and up to 40% of the patients are left with long-lasting sequelae. the endemicity of tbe in sweden has been stable over the years but during the last dec ... | 2002 | 12141758 |
| [synthesis, immunogenicity and antigenic characteristics of the glycoprotein e fragments from the tick-borne encephalitis virus]. | six peptide fragments of the envelope protein e of the tick-borne encephalitis virus involving the predicted t-helper epitopes were synthesized. their ability to induce antibodies without conjugation with any high-molecular-mass carrier was studied in mice of three lines. five of six synthesized peptides exhibited immunogenic properties, which differed in dependence on the haplotype of immunized mice. the peptide binding to the antiviral antibodies was studied, and two peptides were revealed tha ... | 2001 | 11443938 |
| prediction of three-dimensional structure and mapping of conformational epitopes of envelope glycoprotein of japanese encephalitis virus. | japanese encephalitis virus (jev), a mosquito-borne flavivirus, is an important human pathogen. the envelope glycoprotein (egp), a major structural antigen, is responsible for viral haemagglutination and eliciting neutralising antibodies. the three-dimensional structure of the egp of jev was predicted using the knowledge-based homology modeling approach and x-ray structure data of the egp of tick-borne encephalitis virus as a template (rey et al., 1995). in the initial stages of optimisation, a ... | 1999 | 10441554 |
| the molecular biology of tick-borne encephalitis virus. review article. | tick-borne encephalitis (tbe) virus is a member of the flavivirus genus and the family flaviviridae. like other flaviviruses such as yellow fever, japanese encephalitis or the dengue viruses, it is an important human pathogen, endemic in many european countries, russia and china. the disease can be effectively prevented by vaccination with a formalin-inactivated whole virus vaccine. in recent years major advances have been made in the understanding of the molecular biology of tbe virus, includin ... | 1993 | 8267950 |
| the langat model for tick-borne encephalitis virus. specific detection by rt-pcr. | we have developed a reverse-transcriptase polymerase chain reaction assay for rapid detection of langat (lgt) virus, a flavivirus that is closely related to the highly pathogenic tick-borne encephalitis (tbe) viruses. unlike tbe viruses, lgt virus exhibits a significantly lower virulence for man. the assay serves as a safe alternative for the development and optimization of specific assays for the highly pathogenic subtypes of tbe viruses that are endemic throughout much of europe, the former so ... | 1993 | 7505284 |
| reliability of the rabbit pyrogen test and of the limulus test in predicting the pyrogenicity of vaccines in man. | commercial vaccines including bacterial as well as live and inactivated viral vaccines were examined in the rabbit pyrogen test and in the limulus test. the laboratory results were compared with the reactivity in humans. a fairly good correlation was found between the temperature rise in rabbits and the frequency of febrile reaction in the vaccinees. two rabies vaccines and a tick-borne encephalitis virus vaccine, each pyrogenic both in rabbit and in man. were negative in the limulus test. the p ... | 1981 | 7304271 |
| host and viral traits predict zoonotic spillover from mammals. | the majority of human emerging infectious diseases are zoonotic, with viruses that originate in wild mammals of particular concern (for example, hiv, ebola and sars). understanding patterns of viral diversity in wildlife and determinants of successful cross-species transmission, or spillover, are therefore key goals for pandemic surveillance programs. however, few analytical tools exist to identify which host species are likely to harbour the next human virus, or which viruses can cross species ... | 2017 | 28636590 |
| [use of continuous human lymphoblastoid cell lines (t- and b-origin) to produce persistent tick-borne encephalitis virus and venezuelan equine encephalomyelitis virus infections]. | persistent infection with tick-borne encephalitis virus (tbe) was established in experimentally infected continuous lymphoblastoid human cell lines raji, l-101 (of b-origin) and 1387 (t-origin) and with venezuelan equine encephalomyelitis (vee) virus in raji and 1387 lines. the persistently infected lines produced infectious virus, the cells showed specific fluorescence in immunofluorescent tests, and electron microscopic examinations revealed tbe and vee virions in sections. | 1981 | 7023055 |
| [development of cellular immunity in experimental tick-borne encephalitis]. | the development of cellular immunity was investigated in mice infected experimentally with tick-borne encephalitis virus strains (tbe) isolated from patients. in the presence of strain variants of the response, two main trends in the dynamics of cellular immunity induced by different virus strains were established: a rapid increase in the level of sensitization of lymphoid cells in the first days after virus inoculation followed in the stage of paralysis by the desensitization phenomenon (the dy ... | 1981 | 6973240 |
| propagation of tick-borne encephalitis virus in human diploid cells. | | 1965 | 4379477 |
| reproduction of tick-borne encephalitis virus in a human diploid cell strain. | | 1965 | 4379476 |
| virus safety of human immunoglobulins: efficient inactivation of hepatitis c and other human pathogenic viruses by the manufacturing procedure. | human immunoglobulins are plasma derivatives with a low risk of transmitting viral infections. to the present, no proven case of human immunoglobulins transmitting human immunodeficiency viruses has been reported. however, there have been a few reports on the transmission of hepatitis c virus by these plasma proteins. to improve further the safety of both 5s iv human immunoglobulins and 7s im immunoglobulins, we introduced a 10-hour heat treatment of the aqueous solutions at 60 degrees c (i.e., ... | 1992 | 1314286 |
| acute facial palsy. some clinical and virological observations. | a prospective clinical and virological study on 44 patients with acute, peripheral facial paralysis was carried out in consecutive cases during one year. in 9 cases varicella-zoster infections were serologically established. in 5 additional patients an associated varicella-zoster, or herpes simplex, infection was possible. of the 9 confirmed cases, 6 were clinically diagnosed as zoster oticus, whereas on clinical grounds, 3 were regarded as bell's palsy. no evidence was obtained of associated en ... | 1976 | 179268 |
| [dry erythrocytic diagnostic agent for the determination of antiglobulins]. | dry erythrocytic diagnostic agents were obtained under experimental conditions for determination of antiglobulins forming in the organism of man and animals under the effect of serum preparations from the blood of horses and homologoum immunoglobulins. a study was made of the sera of 100 patients with tick-borne encephalitis treated with heterologous and homologous immunoglobulins of directed action; in response to the administration of horse gamma-globulin antiglobulins (in titres below 1 : 100 ... | 1975 | 56112 |
| replication dynamics of tick-borne encephalitis virus in, and glycolytic activity of, human diploid cells. | tick-borne encephalitis (tbe) virus (western subtype) strains replicated very rapidly in human diploid embryonic lung (hdel) cells, namely within the first 24 hours of infection. greater amounts of both intra- and extracellular virus were produced after inoculation of a virulent than of an attenuated strain. with the virulent strain, more infectious virus was found in the medium than in the cells: the opposite was true for the attenuated strain. no cytopathic effect was observed during the perio ... | 1976 | 9821 |
| prevention of tick-borne diseases. | tick-borne diseases are on the rise. lyme borreliosis is prevalent throughout the northern hemisphere, and the same ixodes tick species transmitting the etiologic agents of this disease also serve as vectors of pathogens causing human babesiosis, human granulocytic anaplasmosis, and tick-borne encephalitis. recently, several novel agents of rickettsial diseases have been described. despite an explosion of knowledge in the fields of tick biology, genetics, molecular biology, and immunology, trans ... | 2008 | 17877457 |
| changes in the metabolic activity of macrophages under the influence of tick-borne encephalitis virus. | the metabolic activity of macrophages infected with tick-borne encephalitis virus (tbev) affecting the human nervous system has been studied for the first time. the penetration and reproduction of tbev in the macrophages stimulated their oxygen metabolism, increasing the activity of nadph-oxidase complex, as well as the mitochondrial enzymes lactate dehydrogenase, succinate dehydrogenase, and cytochrome oxidase. a wave-like change in the activity of these enzymes in the macrophages reflected the ... | 2007 | 17367298 |
| tick-borne encephalitis virus ns5 associates with membrane protein scribble and impairs interferon-stimulated jak-stat signalling. | tick-borne encephalitis virus (tbev) ns5 protein is a multifunctional rna-dependent rna polymerase that is indispensable for viral replication. tbev is considered to be highly neurovirulent and can cause lethal encephalitis. in this study, we demonstrate a novel interaction between tbev ns5 and the pdz protein scribble (hscrib) affecting interferon (ifn) type i and ii mediated jak-stat signalling. the sequence of tbev ns5 interacting with hscrib was identified using extensive site-directed mutag ... | 2008 | 18042258 |
| prevalence of tick-borne encephalitis virus in ixodes ricinus from a novel endemic area of north eastern italy. | in alpine area of extreme north eastern italy the first autochthonous case of tbe was reported in 1998 and was followed by 45 cases during the period 2001-2007, thus defining this area as definitely endemic. an ecological survey evaluated the tick density and the tick-borne encephalitis virus (tbev) infection prevalence in tick collected in selected sites. in addition, tbe strains were characterized by sequencing and phylogenetic analysis. overall, 2,361 ticks (2,198 nymphs and 163 adults) of th ... | 2009 | 19107965 |
| morphological changes in human neural cells following tick-borne encephalitis virus infection. | tick-borne encephalitis (tbe) is one of the leading and most dangerous human viral neuroinfections in europe and north-eastern asia. the clinical manifestations include asymptomatic infections, fevers and debilitating encephalitis that might progress into chronic disease or fatal infection. to understand tbe pathology further in host nervous systems, three human neural cell lines, neuroblastoma, medulloblastoma and glioblastoma, were infected with tbe virus (tbev). the susceptibility and virus-m ... | 2009 | 19264624 |
| prevalence and genetic variability of tick-borne encephalitis virus in host-seeking ixodes ricinus in northern italy. | tick-borne encephalitis (tbe) is a severe disease that has been endemic in north-east italy since 1992. over the past two decades, there has been an increase in the number of human cases reported in many european countries, including italy. to assess the current tbe infection risk, questing ticks were collected from known tbe foci, as well as from a site in northern italy where no human infections have been reported previously. a total of 1739 ixodes ricinus (1485 nymphs and 254 adults) was coll ... | 2009 | 19675189 |
| ixodes ricinus tick saliva modulates tick-borne encephalitis virus infection of dendritic cells. | tick-borne encephalitis virus is an important human pathogen, naturally delivered into host skin via a tick bite. to examine the effects of the virus on dendritic cell biology, we cultured dendritic cells with two tick-borne encephalitis virus strains of different virulence in the presence of ixodes ricinus tick saliva. tick saliva treatment increased proportion of virus-infected cells, led to a decrease in virus-induced tnf-alpha and il-6 production and to reduced virus-induced apoptosis. our d ... | 2010 | 20381639 |
| chimeric antibodies against tick-borne encephalitis virus. | two chimeric antibodies (ch) 13d6 and 10c2 against the glycoprotein e of tick-borne encephalitis virus (tbev) were constructed by fusing variable regions of murine monoclonal antibodies (mabs) 13d6 and 10c2 to human constant regions. monovalent analogues of these antibodies in format of single-chain antibodies (scfv or sc) were developed, as well. the ch13d6, ch10c2, sc13d6 and sc10c2 exhibited binding characteristics similar to parental mabs. only the ch13d6 and sc13d6 were able to neutralize t ... | 2010 | 20538092 |
| tick-borne encephalitis virus in ticks in finland, russian karelia and buryatia. | tick-borne encephalitis (tbe) is a central nervous system infection caused by a flavivirus [tick-borne encephalitis virus (tbev)], transmitted by ixodes ticks and endemic in a large region in eurasia. we collected 2411 ticks from finland and russia in 2003-2008, screened them for tbev by rt-pcr and isolated and analysed eight strains belonging to all three tbev subtypes; in addition, we obtained two european-subtype strains from human serum samples. tbev rna prevalence in unengorged ticks was ap ... | 2010 | 20660147 |
| detection and differentiation of tick-borne encephalitis virus subtypes by a reverse transcription quantitative real-time pcr and pyrosequencing. | tick-borne encephalitis (tbe) virus causes one of the most important flaviviral infections of the human central nervous system in europe and asia. in recent years the rate of tbe infection has been raising and the virus has been spreading to new areas. currently, the diagnosis of tbe is based on detection of specific antibodies in patients' sera which appear as late as about 2 weeks post-infection. for a timely diagnosis of tbe virus infections and epidemiological studies, a tbe virus-specific r ... | 2010 | 20933016 |
| variability in the 2'-5'-oligoadenylate synthetase gene cluster is associated with human predisposition to tick-borne encephalitis virus-induced disease. | the 2'-5'-oligoadenylate synthetase (2'-5'-oas) family members are interferon-induced antiviral proteins. twenty-three single nucleotide polymorphisms located within the oas1, oas2, oas3, and oasl genes were analyzed in 142 patients with russian tick-borne encephalitis. statistically significant differences in genotype, allele, and haplotype frequencies for 3 oas2 single nucleotide polymorphisms (rs1293762, rs15895, and rs1732778) and 2 oas3 single nucleotide polymorphisms (rs2285932 and rs20721 ... | 2010 | 21050126 |
| insertion of microrna targets into the flavivirus genome alters its highly neurovirulent phenotype. | flaviviruses such as west nile, japanese encephalitis, and tick-borne encephalitis (tbev) viruses are important neurotropic human pathogens, causing a devastating and often fatal neuroinfection. here, we demonstrate that incorporation into the viral genome of a target sequence for cellular micrornas expressed in the central nervous system (cns) enables alteration of the neurovirulence of the virus and control of the neuropathogenesis of flavivirus infection. as a model virus for this type of mod ... | 2010 | 21123372 |
| [transmission and circulation of tick borne pathogens (tbe and lyme borreliosis) and the role of changing environment]. | ixodes ricinus is regarded as a species with great medical and veterinary meaning. transmission of tick borne pathogens in mammals depends not only on systemic infection. transmission of b. burgdorferi and tick-borne encephalitis virus in an infected organism differs, because of different location in tick, the differences in dissemination of the virus and bacteria (own motility) as well as mechanisms supporting bacterial infection. the mechanisms governing the transmission of these pathogens in ... | 2010 | 21473069 |
| emerging theme: cellular pdz proteins as common targets of pathogenic viruses. | more than a decade ago three viral oncoproteins - adenovirus type 9 e4-orf1, human t-lymphotropic virus type 1 tax, and high-risk human papillomavirus e6 - were found to encode a related carboxyl-terminal pdz domain-binding motif (pbm) that mediates interactions with a select group of cellular pdz proteins. recent studies have shown that many other viruses also encode pbm-containing proteins that bind to cellular pdz proteins. interestingly, these recently recognized viruses include not only som ... | 2011 | 21775458 |
| [Multidirectional effect of MIF and sodium polyprenyl phosphate on the course of experimental flavivirus infection in mice]. | Study of macrophage migration inhibiting factor (MIF) effect after intracerebral administration on the course of experimental infection induced in mice by tick borne encephalitis virus (TEV), and study of sodium polyprenyl phosphate (PPP) and/or antibodies against MIF on the course of this infection against the background of MIF administration. | 2011 | 22145351 |
| changes in the geographical distribution and abundance of the tick ixodes ricinus during the past 30 years in sweden. | abstract: background: ixodes ricinus is the main vector in europe of human-pathogenic lyme borreliosis (lb) spirochaetes, the tick-borne encephalitis virus (tbev) and other pathogens of humans and domesticated mammals. the results of a previous 1994 questionnaire, directed at people living in central and north sweden (svealand and norrland) and aiming to gather information about tick exposure for humans and domestic animals, suggested that ixodes ricinus ticks had become more widespread in cent ... | 2012 | 22233771 |