Publications

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studies on vaccination against papillomaviruses: the immunity after infection and vaccination with bovine papillomaviruses of different types.calves, free of antibodies to bovine papillomaviruses (bpv), were reared in isolation. one was infected with bpv-2, developed tumours and was resistant to homologous reinfection. groups of calves were infected with bpv-2, bpv-5 or bpv-6; they all developed and subsequently rejected type-specific tumours. they were then infected with bpv-4; they were not immune and oral papillomas were induced. groups of animals were vaccinated by intramuscular preparations of purified bpv-4 and bpv-6 and were ch ...19902161579
papillomavirus infection in cattle: viral and chemical cofactors in naturally occurring and experimentally induced tumours.six different types of bovine papillomavirus (bpv-1 to bpv-6) have been identified and classified into two subgroups: subgroup a, which induce fibropapillomas, and subgroup b, which induce true epithelial papillomas. bpv-4, a member of subgroup b, is the aetiological agent of papillomas of the upper alimentary canal, which can become a focus for transformation to squamous-cell carcinomas in animals feeding on bracken fern. strong circumstantial evidence suggests that the progression to malignanc ...19863013519
papillomas of the teats and udder of cattle and their causal viruses.an abattoir survey was carried out on 1657 cattle to determine the incidence and parameters of teat and udder papillomas and their causal viruses. recent research has characterised six different bovine papillomaviruses of which three have been found to be particularly associated with teat tumours. of the population studied 37.3 per cent had teat warts and 86.2 per cent of these had multiple infections; 28.4 per cent had papillomas attributed to bovine papillomavirus 1, 88.5 per cent to bovine pa ...19846098066
a novel silencer element in the bovine papillomavirus type 4 promoter represses the transcriptional response to papillomavirus e2 protein.the long control regions (lcrs) of mucosal epitheliotropic papillomaviruses have similar organizations: a promoter region, an enhancer region, and a highly conserved distribution of e2 dna binding sites (c. desaintes and c. demeret, semin. cancer biol. 7:339--347, 1996). the enhancer of these viruses is epithelial cell specific, as it fails to activate transcription from heterologous promoters in nonepithelial cell types (b. gloss, h. u. bernard, k. seedorf, and g. klock, embo j. 6:3735--3743, 1 ...200111222708
an outbreak of teat papillomatosis in cattle caused by bovine papilloma virus (bpv) type 6 and unclassified bpvs.out of 700 heifers at a local farm in hokkaido, the northern island of japan, 560 (80%) were found to have benign teat tumors. all of the analyzed tumors were macroscopically of the flat-and-round type, and no other types such as rice-grain or frond epithelial type were found. the lesions were characterized by epithelial hyperplasia, acanthosis and hyperkeratosis. unlike in typical fibropapilloma, fibroplasia of the underlying dermis was not observed. bovine papilloma virus (bpv) capsid antigen ...200717239550
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