whipple's disease with aortic regurgitation requiring aortic valve replacement.cardiac involvement in whipple's disease is well established. however, clinical consequences beside antibiotic therapy have rarely been reported. our observation of a middle-aged man with increasing dyspnea, fatigue, chest pain, and dizziness leading to admission to a cardiology department demonstrates that cardiac symptoms may represent the main symptoms in patients with whipple's disease. the diagnosis was not made prior to upper endoscopy, performed because of diarrhea, and revealed whipple's ...19989646112
marginal and subgingival plaque--a natural habitat of tropheryma whipplei?dna of tropheryma whipplei, the etiologic agent of whipple's disease, has recently been detected in the saliva of healthy subjects. in this pilot study we searched for the habitat of t. whipplei within the oral cavity.200312682813
cultivation of tropheryma whipplei from cerebrospinal fluid.whipple disease (wd) is a systemic disorder caused by the bacterium tropheryma whipplei. since the recognition of a bacterial etiology in 1961, many attempts have been made to cultivate this bacterium in vitro. it was eventually isolated, in 2000, from an infected heart valve, in coculture with human fibroblasts. here we report the isolation of 2 new strains of t. whipplei from cerebrospinal fluid (csf) of 2 patients with intestinal wd but no neurological signs or symptoms. one culture-positive ...200312964110
eosinophilic vasculitis: a rare presentation of whipple's disease.whipple's disease is a multisystem infectious disease caused by the bacterium tropheryma whippelii. a case with an unusual presentation is reported. a 66-year-old man presented with a febrile vasculitic rash on his forearms. an extensive rheumatological, hematological and infectious workup gave negative results, apart from mild anemia and eosinophilia. an abdominal computed tomography revealed a retroperitoneal lymphadenopathy, and a skin biopsy revealed an eosinophilic vasculitis. this diverted ...200717377649
whipple's disease: neurological relapse presenting as headache for two years.whipple's disease is a rare, chronic, multi-systemic infectious disorder caused by the bacterium, tropheryma whipplei. relapses are commonly associated with neurological symptoms. we report a case of a 55-year-old man who presented with symptoms of progressive headache, 13 years after apparent complete recovery from intestinal whipple's disease. studies showed hydrocephalus with obstruction of the aqueduct and cerebrospinal fluid findings consistent with chronic meningitis. diagnosis of central ...200818784966
erythema nodosum-like lesions in treated whipple's disease: signs of immune reconstitution inflammatory syndrome.treatment of systemic infections due to mycobacteria and hiv infection can lead to paradoxical worsening, the immune reconstitution inflammatory syndrome, in a minority of patients. herein we describe a patient with whipple's disease, a chronic systemic inflammatory disease caused by tropheryma whipplei, who developed cutaneous and later ocular disease after initiation of antibiotic therapy. a 42-year-old man with a 12-year history of arthralgias presented with deteriorating health, including we ...200919150271
tropheryma whipplei tricuspid endocarditis: a case report and review of the literature.abstract:201020684779
complete genome sequence of cellulomonas flavigena type strain (134).cellulomonas flavigena (kellerman and mcbeth 1912) bergey et al. 1923 is the type species of the genus cellulomonas of the actinobacterial family cellulomonadaceae. members of the genus cellulomonas are of special interest for their ability to degrade cellulose and hemicellulose, particularly with regard to the use of biomass as an alternative energy source. here we describe the features of this organism, together with the complete genome sequence, and annotation. this is the first complete geno ...201021304688
tropheryma whipplei in children with gastroenteritis.tropheryma whipplei, which causes whipple disease, is found in human feces and may cause gastroenteritis. to show that t. whipplei causes gastroenteritis, pcrs for t. whipplei were conducted with feces from children 2-4 years of age. western blotting was performed for samples from children with diarrhea who had positive or negative results for t. whipplei. t. whipplei was found in samples from 36 (15%) of 241 children with gastroenteritis and associated with other diarrheal pathogens in 13 (33%) ...201020409366
[macrophagic myofascitis vs atypical whipple's disease].a 39-year-old man presented pronounced asthenia and diffuse myalgias 8 months after a vaccination against the tetanus toxoid. muscle biopsy disclosed infiltration of the perimysium and endomysium by densely packed, pas-positive macrophages. tropheryma whippelii detection in blood and faeces allowed the initial assumption of atypical whipple's disease with isolated muscle involvement. however, the histological detection of aluminium-containing macrophages by means of morin stain immunofluorescenc ...200818726082
an atypical case of whipple's disease: case report and review of the literature.we report the case of a 57-year-old man, presenting with bilateral panuveitis, bilateral sacroiliitis, intermittent pyrexia and a pulmonary nodule. the patient had been under immunosuppressive treatment for 2 years for behçet's disease. however, he did not fulfill the diagnostic criteria of behçet's disease. blood analysis showed a very high c reactive protein (crp at 34 mg/dl). in view of severe intra-ocular inflammation, the anterior chamber was punctured. polymerase chain reaction (pcr) on th ...200818575052
current concepts of immunopathogenesis, diagnosis and therapy in whipple's disease.whipple's disease (wd) is a rare chronic infectious disorder caused by the rod- shaped bacterium tropheryma whipplei. the disorder is characterized clinically by arthralgia, abdominal pain, diarrhea, malabsorbtion and progressive weight loss. other important sites of infection include the heart (resulting in the clinical picture of endocarditis and heart failure) and the central nervous system (cns) (manifestations include confusion, memory loss, focal cranial nerve signs, nystagmus and ophtalmo ...200617073638
evolutionary constraints on codon and amino acid usage in two strains of human pathogenic actinobacteria tropheryma whipplei.the factors governing codon and amino acid usages in the predicted protein-coding sequences of tropheryma whipplei tw08/27 and twist genomes have been analyzed. multivariate analysis identifies the replicational-transcriptional selection coupled with dna strand-specific asymmetric mutational bias as a major driving force behind the significant interstrand variations in synonymous codon usage patterns in t. whipplei genes, while a residual intrastrand synonymous codon bias is imparted by a select ...200616557339
[whipple's disease--a challenging diagnosis].whipple's disease is a rare multisystemic disease caused by gram-positive bacillus, tropheryma whippelii, family of actinobacterias and group of actinomycetes. because the disease is rare and has different forms of presentation the diagnosis comes frequently late. the authors present the case of a white man, 50 years old, admitted with a clinical picture characterized by weight loss, abdominal pain, ascites, diarrhea. he suffered of arthralgias for four years. the diagnosis was made by biopsy of ...200416197860
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