Publications

mycobacterium heckeshornense lung infection that was diagnosed as mycobacterium xenopi disease by dna-dna hybridization (ddh).	the dna sequencing analyses of the 16s rrna gene, rpob and hsp65 were conducted to characterize six strains that had been identified as mycobacterium xenopi by dna-dna hybridization (ddh) for past ten years in our hospital. the results revealed mycobacterium heckeshornense infection in one of the six cases. a 47-year-old man, who had been treated for pneumonia, had pulmonary nontuberculous mycobacterial disease. the sputa from the patient were culture positive for mycobacterium in three times. a ...	2011	21628944
semisynthesis of membrane-attached prion proteins.	conversion of cellular prion protein (prp(c)) into the pathological conformer (prp(sc)) is the hallmark of prion diseases and has been studied extensively by using recombinantly expressed prp (rprp). because of the inherent difficulties of expressing and purifying posttranslationally modified rprp variants only a limited amount of data is available for membrane-associated prp and its behavior in vitro and in vivo. protein semisynthesis provides two alternative routes to access multimilligram amo ...	2009	19632475
pulmonary disease caused by mycobacterium xenopi: the first case in korea.	mycobacterium xenopi is a nontuberculous mycobacterium (ntm) that rarely causes pulmonary disease in asia. here we describe the first case of m. xenopi pulmonary disease in korea. a 66-year-old man was admitted to our hospital with a 2-month history of productive cough and hemoptysis. his past medical history included pulmonary tuberculosis 44 years earlier, leading to a right upper lobectomy. chest x-ray upon admission revealed cavitary consolidation involving the entire right lung. numerous ac ...	2007	17963348
[peculiar "chestnuts in burrs" formation in mgit cultures of pulmonary mycobacterium xenopi cases].	we report 3 patients whose sputum and bronchoalveolar lavage fluid (balf) cultures for acid fast bacteria in mgit liquid media grew colonies of mycobacterium xenopi (m. xenopi) with a characteristic chestnut burr like appearance. patients i, ii, and iii were a 74-year-old man, 47-year-old woman, and 62-year-old woman, respectively. chest x ray showed a pulmonary cavity in each case. patient i had a history of pulmonary and renal tuberculosis. the past medical history of patient ii was unremarkab ...	2007	18283860
mycobacterium xenopi multiplies within human macrophages and enhances hiv replication in vitro.	mycobacterium xenopi can cause opportunistic infections, particularly in persons infected with human immunodeficiency virus type 1 (hiv-1). the primary focus of this effort was to determine if m. xenopi isolates could survive and grow in human peripheral blood macrophage (mphi), and if these isolates could promote the replication of hiv-1 in vitro. m. xenopi bacilli survived and replicated 10-fold within 48 h in human mphi while avirulent mycobacterium smegmatis, did not grow within the mphi. m. ...	2006	16371246
[molecular identification of mycobacteria and detection of antibiotic resistance].	mycobacteria are responsible for many human infections, especially species of tuberculosis complex, causative agents of tuberculosis. with nine millions new cases every year, this disease is responsible for more than two millions of deaths. nontuberculous mycobacteria (e.g. mycobacterium avium-intracellulare, mycobacterium kansasii, mycobacterium xenopi or mycobacterium ulcerans) can cause infections too, usually in particular clinical settings. standard diagnosis of mycobacterial infections rel ...	2004	15297234
pulmonary mycobacterium xenopi infection in aids patients treated with haart in hungary.	reported here are three cases of pulmonary mycobacterium xenopi infection that occurred in aids patients in hungary shortly after starting highly active antiretroviral therapy. in this country, mycobacterium xenopi is the most common nontuberculous mycobacterial species causing pulmonary mycobacterial infections. cases of pulmonary mycobacterium xenopi disease have been described in patients infected with the human immunodeficiency virus infection and in patients with other immunodeficiencies; h ...	2003	14557921
human immunodeficiency virus type 1-related pulmonary mycobacterium xenopi infection: a need to treat?	we report treatment decisions and outcomes for 20 patients who were infected with human immunodeficiency virus type 1 (hiv-1) and were receiving highly active antiretroviral therapy (haart) who had respiratory symptoms and from whom mycobacterium xenopi was isolated. all patients also had coexisting pulmonary pathologic conditions. the median blood t cell cd4 count was 37 cells/microl (range, 2-480 cells/microl). fifteen of 20 patients received no antimycobacterial therapy and remain healthy aft ...	2003	14557971
evaluation of the bactericidal efficiency of a 2% alkaline glutaraldehyde solution on mycobacterium xenopi.	mycobacterium xenopi (m. xenopi) has been implicated in hospital-acquired infections associated with colonization of hospital water systems. m. xenopi is considered to be as resistant as other atypical mycobacteria, which are known to be resistant to many disinfecting treatments. however, the efficacy of disinfectants on this organism has not yet been studied. therefore we decided to evaluate its susceptibility to 2% alkaline glutaraldehyde solution, which is commonly used in hospitals. tests we ...	2000	11023727
[a case of pulmonary infection with mycobacterium xenopi].	a 42-year-old man with pulmonary disease caused by mcobacterium xenopi is described. he had a history of alcohol use of over 20 years. he was admitted to another hospital for evaluation of an abnormal chest shadow. a chest x-ray showed a cavitary shadow with infiltration in the right upper lung field. acid-fast organisms were recognized in sputum and m. xenopi was identified by dna-dna hybridization. although he had been treated with isoniazid, rifampicin, and ethanbutol for 5 years, sputum rema ...	1998	9611983
mycobacterium xenopi: innocent bystander or emerging pathogen?	mycobacterium xenopi is a recognized cause of smoldering pulmonary disease in patients with chronic lung disease. this organism is frequently isolated from respiratory specimens from individuals infected with human immunodeficiency virus (hiv) and is often considered nonpathogenic. cases of pulmonary and disseminated m. xenopi disease have been described in patients with hiv infection and other immunodeficiencies. many physicians are unaware of the clinical significance of m. xenopi isolation. w ...	1997	9114152
atypical mycobacteriosis as a complication of talc pneumoconiosis.	a 57 year old man, receiving compensation for talc pneumoconiosis since 1977, was admitted to hospital for the first time in 1987, with symptoms of weight loss, fever, dyspnoea and productive cough. a chest roentgenogram showed bilateral cavitation. two years later, mycobacterium xenopi was found in sputum cultures. despite specific oral antibiotherapy, the patient's health deteriorated and he died in 1990. to the best of our knowledge, this is the first reported case of an association of talcos ...	1996	8866607
[atypical mycobacteriosis (mycobacterium xenopi) with "initial aggravation"].	a 66-year-old man was admitted to nara medical university hospital because of sputum production and fevre. a chest x-ray film obtained on admission revealed many cysts and an infiltrative shadow in the right upper lung field. the patient was treated with antimycobacterial drugs (isoniazid 400 mg, streptomycin 0.75 g, and rifampicin 450 mg) because acid-fast bacilli were detected in his sputum. although the symptoms and laboratory data improved, a new infiltrative shadow developed in the right lo ...	1996	8937151
[pneumonia due to a rare atypical mycobacterium in aids].	a 38-year-old man, hiv-positive for 6 years, developed fever and cough with deterioration in his general state. chest radiography demonstrated an infiltration in the left upper lobe and computed tomography showed a septated cavity. three bronchioalveolar lavages over 4 weeks recovered klebsiella, candida, pseudomonas and staphylococcus in the lavage fluid. acid-fast rods were not found in any of the microscopic preparations. his clinical condition and the radiological findings deteriorated despi ...	1993	8223223
[a lupus-vulgaris like atypical mycobacteriosis caused by mycobacterium xenopi (lupus xenopi)].	a case of lupus-vulgaris-like infection caused by mycobacterium xenopi in a 62-year-old immunocompetent female patient is presented. a large cutaneous infiltration was seen in the right periorbital region. histological examination revealed a granulomatous reaction of epithelioid cells and giant cells. m. xenopi was isolated from biopsy material and tuberculosis could be excluded. isoniazid was effective in healing the lesion within a year. such infections are well known for other mycobacteria bu ...	1992	1399603
mycobacterium xenopi, a potential human pathogen.	mycobacterium xenopi is infrequently recognized as a cause of pulmonary disease. during a 12-year survey (1978-89),. 108 strains of this mycobacterium were isolated from 90 persons and 6 hot water samples. from 87 patients 89 occasional strains of m. xenopi were isolated, and 3 patients were diagnosed as having pulmonary mycobacteriosis caused by it. the treatment and the response in these three cases were variable, depending on clinical conditions and sensitivity to drugs. most of the strains i ...	1992	1468888
pulmonary disease due to mycobacterium xenopi in a renal allograft recipient: report of a case and review.	a 39-year-old man with pulmonary disease due to mycobacterium xenopi is described. he had received prednisone and azathioprine for 5 years and prednisone in combination with cyclosporin a for 1 year in an effort to prevent rejection of his renal transplant. shortly after the renal allograft was removed because of chronic rejection, the patient developed dyspnea and a decrease in vitality. he had no history of preexisting lung disease. a chest roentgenogram showed multiple nodular infiltrates in ...	1989	2690290
mycobacterium xenopei pulmonary infection in man.		1971	5576426