| [autopsy case of lissauer's general paresis with rapidly progressive left hemiparesis]. | a 48-years-old man presented with slowly progressive bradykinesia, personality change and rapidly progressive left hemiparesis. on admission, he presented dementia, poor judgment, left hemiparesis. mri revealed a widespread high intensity area in right hemisphere and mra was almost normal. serological tests of serum and csf demonstrated high titers of antibodies to treponema pallidum. he was treated for syphilis with daily penicillin injections without improvement. he died of sepsis eight months ... | 2009 | 19618844 |
| ocular syphilis associated with syphilitic resurgence in a human immunodeficiency virus-infected man. | optometrists provide an important service to the community, often acting as the first health care provider a patient consults. many patients will present with ocular complaints that have systemic associations. in addition to diabetes, hypertension, and rheumatologic disorders, optometrists can encounter the ocular manifestations of sexually transmitted diseases such as syphilis. syphilis is a chronic systemic infection caused by the spirochete treponema pallidum, which is transmitted primarily t ... | 2008 | 19811765 |
| the direct cultivation of treponema pallidum pathogenic for the monkey. | a method for the direct cultivation of treponema pallidum from human syphilitic lesions, by the employment of a solid medium, has been described. by means of it, three of the four strains worked with were successfully cultivated. the several pure cultures agree in morphological and cultural characters, grow only in the presence of sterile tissue under anaerobic conditions, and do not produce putrefactive odors. the morphology is typical under optimum cultural conditions; it becomes atypical when ... | 1912 | 19867508 |
| brain lesions of the domestic rabbit. | lesions of meningoencephalitis were found in 55 per cent of 372 rabbits comprising the laboratory stock regarded as healthy, others with snuffles or dying from different affections while being kept under observation, and still others which were employed for experimental purposes, such as tumor transplantation and treponema pallidum inoculation. none was injected intracerebrally. the lesions consist in the main of infiltration with mononuclear cells occurring around the blood vessels, in the meni ... | 1924 | 19868834 |
| prolonged maintenance of spirochetes and filtrable viruses in the frozen state. | 1. observations are reported on the virulence of various types of spirochetes and filtrable viruses after storage at - 787deg;c. for periods up to 3 years. 2. five specimens of treponema pallidum belonging to 4 different strains, and 7 specimens of t. pertenue belonging to 5 different strains were tested after storage for approximately 3 years. with one exception each specimen contained actively motile treponemes, and all specimens were highly pathogenic for rabbits. many other specimens of thes ... | 1939 | 19870935 |
| infectious antibodies in systemic lupus erythematosus patients. | infections can act as environmental triggers that induce or promote systemic lupus erythematosus (sle) in genetically predisposed individuals. new technologies, developed recently, enable simultaneous assessment of multiple antibodies. antibodies to specific infectious agents may shed light into the mechanisms of induction of sle. the aim of this study was to investigate the prevalence of seropositivity and the titers of antibodies to bacterial, viral, and parasitic agents in sle patients compar ... | 2009 | 19880558 |
| clinical presentation and imaging of general paresis due to neurosyphilis in patients negative for human immunodeficiency virus. | the clinical presentations and mri of six patients with general paresis due to neurosyphilis were reviewed. diagnosis was based on neurological and psychiatric symptoms, positive treponema pallidum hemagglutination in cerebrospinal fluid (csf) and sera, and serology that was negative for human immunodeficiency virus by enzyme-linked immunosorbent assay. most patients had lymphocytic, monocytic pleocytosis and high protein levels in their csf. one patient had periodic lateral epileptiform dischar ... | 2010 | 20080408 |
| characterization and serologic analysis of the treponema pallidum proteome. | treponema pallidum subsp. pallidum is the causative agent of syphilis, a sexually transmitted disease characterized by widespread tissue dissemination and chronic infection. in this study, we analyzed the proteome of t. pallidum by the isoelectric focusing (ief) and nonequilibrating ph gel electrophoresis (nephge) forms of two-dimensional gel electrophoresis (2dge), coupled with matrix-assisted laser desorption ionization-time of flight (maldi-tof) analysis. we determined the identity of 148 t. ... | 2010 | 20385758 |
| production of proinflammatory cytokines in the human thp-1 monocyte cell line following induction by tp0751, a recombinant protein of treponema pallidum. | the tissue destruction characteristic of syphilis infection may be caused by inflammation due to treponema pallidum and the ensuing immune responses to the pathogen. t. pallidum membrane proteins are thought to be potent inducers of inflammation during the early stages of infection. however, the actual membrane proteins that induce inflammatory cytokine production are not known, nor are the molecular mechanisms responsible for triggering and sustaining the inflammatory cascades. in the present s ... | 2010 | 20596832 |
| malignant syphilis with ocular involvement in an hiv-infected patient. | malignant syphilis is now considered a rare disease, more commonly affecting individuals with poor health, malnutrition or hiv infection. we present a 34-year-old man with hiv infection who developed multiple atypical cutaneous ulcerations, leonine facies, a scleral nodule and keratitis with visual loss. the diagnosis of malignant syphilis was delayed due to the insidious presentation, but was confirmed via immunohistochemical (ihc) staining with anti-treponema antibodies of a skin biopsy. signi ... | 2011 | 21571984 |
| case records of the massachusetts general hospital. case 26-2010. a 54-year-old man with loss of vision and a rash. | | 2010 | 20818848 |
| [neurosyphilis: unexpected reunion with an old acquaintance]. | a 45-year-old man was admitted to a psychiatric hospital with confusion and disorientation; he was suspected of having korsakoff syndrome. he was known to have a history of alcohol abuse, complicated by epileptic fits, and to have had a recent ischaemic cerebrovascular attack. unexpectedly, screening for syphilis turned out to be positive. examination of the cerebrospinal fluid led to the diagnosis of neurosyphilis. most neurological and psychiatric symptoms disappeared after treatment with anti ... | 2011 | 21319069 |
| treponema infection associated with genital ulceration in wild baboons. | the authors describe genital alterations and detailed histologic findings in baboons naturally infected with treponema pallidum. the disease causes moderate to severe genital ulcerations in a population of olive baboons (papio hamadryas anubis) at lake manyara national park in tanzania. in a field survey in 2007, 63 individuals of all age classes, both sexes, and different grades of infection were chemically immobilized and sampled. histology and molecular biological tests were used to detect an ... | 2011 | 21411621 |
| laryngeal syphilis: a case report. | syphilis is a sexually transmitted disease caused by the spirochete treponema pallidum. the complexity of the disease gained it the moniker "the great imitator"; it was william osler who said, "he who knows syphilis, knows medicine." in 1866, patrick watson of edinburgh, scotland, reported a case of a 36-year-old man in whom syphilis destroyed the larynx.(1) the diagnosis was made postmortem. it was once believed that this was the first reported total laryngectomy, but the credit should actually ... | 2011 | 21422316 |
| risky sexual behavior among patients in turkey with bipolar disorder, schizophrenia, and heroin addiction. | aim. risky sexual behavior associated with such sexually transmitted infections (stis) as hepatitis b and c, herpes, treponema pallidum, and neisseria gonorrhoeae, is more frequent among psychiatric patients and parenteral drug abusers than the general population. the aim of this study was to investigate risky sexual behavior in psychiatric outpatients diagnosed with schizophrenia (sch), bipolar disorder, and heroin addiction (ha), and to compare them with those observed in healthy controls. me ... | 2011 | 21492406 |
| [meningovascular neurosyphilis as the cause of ischemic cerebrovascular disease in a young man]. | authors report a case of a 35-year-old male with right-sided mild paresis, incontinence, dysexecutive syndrome, short-term memory loss and behavioral changes. bilateral cerebral infarcts in the region of the caudate nuclei and the adjacent white matter were proved by brain mri and multiple stenoses of the branches of willis-circle were confirmed by mr angiography. elevated protein level and pleocytosis were found in the cerebrospinal fluid with intrathecal igg synthesis. serum rapid plasma reagi ... | 2011 | 21498167 |