Publications

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second roundtable discussion on taxonomic problems relating to malaria parasites. 19734632261
parasitological review. experimental monkey hosts for human plasmodia. 1975807483
ultrastructure of the erythrocytic stages of plasmodium malariae.this report describes the fine structure of the erythrocytic stages of plasmodium malariae. erythrocytic parasites from a naturally acquired human infection and an experimentally infected chimpanzee were morphologically indistinguishable and structurally similar to other primate malarias. new findings included observations of highly structured arrays of merozoite surface coat proteins in the cytoplasm of early schizonts and on the surface of budding merozoites and the presence of knobs in the me ...19873309268
in vitro cultivation of exoerythrocytic stages of the human malaria parasite plasmodium malariae.exoerythrocytic stage parasites of plasmodium malariae were obtained in vitro by inoculating primary cultures of hepatocytes from a chimpanzee (pan troglodytes) and a monkey (aotus lemurinus griseimembra) with sporozoites. schizonts were observed in chimpanzee hepatocytes 8, 11, and 13 days after inoculation. only 1 schizont was seen in aotus hepatocytes at day 13. the morphology and development rates of p. malariae exoerythrocytic stages obtained in vitro were similar to those previously descri ...19883079312
antibodies to the ring-infected erythrocyte surface antigen of plasmodium falciparum elicited by infection with plasmodium malariae.the ring-infected erythrocyte surface antigen (resa) of plasmodium falciparum (resa-p), found in the membrane of erythrocytes infected with young asexual stages of p. falciparum, is a promising vaccine candidate. antibodies to resa-p were inducible by infection with another human malaria species, p. malariae. of 298 serum samples from inhabitants of three isolated localities in peru where p. vivax and p. malariae were endemic and p. falciparum had never been reported, 26% had anti-resa-p antibod ...19883278979
infection of chimpanzees with the uganda i/cdc strain of plasmodium malariae.nine splenectomized chimpanzees were infected with the uganda i/cdc strain of plasmodium malariae. two had no history of previous malarial infection, whereas 6 had been infected with p. vivax and 1 with p. vivax and p. ovale. the animals with no previous infection had maximum parasitemias of 8,740 and 10,800/mm3. the other animals had maximum parasite counts of 930-75,700/mm3. anopheles freeborni, an. stephensi, an. dirus, an. maculatus, an. quadrimaculatus, an. culicifacies, an. arabiensis, and ...19902180332
the complete sequence of a plasmodium malariae ssurrna gene and its comparison to other plasmodial ssurrna genes.a gene encoding the small subunit rrna (ssurrna) has been isolated from the human parasite, plasmodium malariae. the gene has been sequenced. it contains conserved and variable regions which conform to patterns established for other eukaryotic ssurrna genes. comparisons with other ssurrna genes from plasmodium species reveal regions unique to p. malariae which could be used in specific diagnostic probes for this organism, and provide evidence that the gene is of the type expressed during asexual ...19912038360
experimental infection of anopheles gambiae s.s., anopheles freeborni and anopheles stephensi with plasmodium malariae and plasmodium brasilianum.susceptibility to infection of 2 strains of anopheles gambiae s.s., an. freeborni and an. stephensi, was determined for 2 closely related malaria parasites, plasmodium malariae and p. brasilianum. neither strain of an. gambiae supported development of oocyst densities as great as the other 2 anopheline mosquitoes. the zan strain of an. gambiae s.s. from zanzibar was more susceptible to infection with the strain of p. malariae from uganda than the g-3 strain of an. gambiae s.s. from the gambia. a ...19938468576
the china i/cdc strain of plasmodium malariae in aotus monkeys and chimpanzees.five aotus monkeys and two chimpanzees were infected with plasmodium malariae isolated from a patient who acquired her infection approximately 50 years ago. all animals were splenectomized. the chimpanzees supported the highest parasite densities of 22,271/microliters and 18,544/microliters. three aotus monkeys with a previous history of infection with p. vivax had maximum parasite counts of from 1,818/microliters to 2,909/microliters, whereas two monkeys not previously infected had maximum para ...19948304570
polymerase chain reaction and a liquid-phase, nonisotopic hybridization for species-specific and sensitive detection of malaria infection.in the present study, we describe a polymerase chain reaction (pcr)-based enzyme-linked immunosorbent assay for the detection of malaria infection. the target region of the 18s ribosomal dna is amplified by a pcr using an 18s rrna, genus-specific, biotinylated (5') and an unlabeled primer (3') pair. the detection probes are digoxigenin-labeled dna oligonucleotides derived from species-specific rrna sequences. the amplified fragments are allowed to hybridize with the species-specific, digoxigenin ...19957872440
identification of plasmodium malariae, a human malaria parasite, in imported chimpanzees.it is widely believed that human malaria parasites infect only man as a natural host. however, earlier morphological observations suggest that great apes are likely to be natural reservoirs as well. to identify malaria parasites in great apes, we screened 60 chimpanzees imported into japan. using the sequences of small subunit rrna and the mitochondrial genome, we identified infection of plasmodium malariae, a human malaria parasite, in two chimpanzees that were imported about thirty years ago. ...200919823579
african apes as reservoirs of plasmodium falciparum and the origin and diversification of the laverania subgenus.we investigated two mitochondrial genes (cytb and cox1), one plastid gene (tufa), and one nuclear gene (ldh) in blood samples from 12 chimpanzees and two gorillas from cameroon and one lemur from madagascar. one gorilla sample is related to plasmodium falciparum, thus confirming the recently reported presence in gorillas of this parasite. the second gorilla sample is more similar to the recently defined plasmodium gaboni than to the p. falciparum-plasmodium reichenowi clade, but distinct from bo ...201020498054
detection of plasmodium falciparum, p. vivax, p. ovale, and p. malariae merozoite surface protein 1-p19 antibodies in human malaria patients and experimentally infected nonhuman primates.approximately 3.2 billion people live in areas where malaria is endemic, and who estimates that 350 to 500 million malaria cases occur each year worldwide. this high prevalence, and the high frequency of international travel, creates significant risk for the exportation of malaria to countries where malaria is not endemic and for the introduction of malaria organisms into the blood supply. since all four human infectious plasmodium species have been transmitted by blood transfusion, we sought to ...201020702658
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