Publications

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effect of sulfaguanidine on the course of infection in chickens with eimeria tenella. 194521013413
on the chemotherapy of caecal coccidiosis (eimeria tenella) of chickens; further studies on the use of drugs in established infections. 194621013323
the chemotherapy of cecal coccidiosis (eimeria tenella) of chickens; experiments on the use of chemotherapy during the immunizing exposure of chicks. 194620988118
sulfaquinoxaline in the prevention of eimeria tenella infections in chickens. 194720290855
on the chemotherapy of caecal coccidiosis (eimeria tenella) of chickens; some further tests of drugs for a coccidiostatic effect. 194720240349
on the chemotherapy of caecal coccidiosis (eimeria tenella) of chickens; observations on sulphonamides in the intestinal tract and blood. 194720258867
effect of sulfamethazine on the coccidian parasite, eimeria tenella, of chickens. 194720296031
on the chemotherapy of caecal coccidiosis, eimeria tenella, of chickens; a note on the metabolism of caecal epithelium, normal and parasitized. 194818865553
sulfaquinoxaline in the control of eimeria tenella and eimeria necatrix in chickens on a commercial broiler farm. 194817791764
bacterial population changes in the ceca of young chickens infected with eimeria tenella. 194816561613
on the chemotherapy of caecal coccidiosis (eimeria tenella) of chickens; the use of a standardized test to determine coccidiostatic properties of drugs. 195015434723
on the chemotherapy of caecal coccidiosis (eimeria tenella) of chickens. viii. field trials of broiler feeds medicated at a low level. 195114839554
nitrofurazone for the prevention of experimentally induced eimeria tenella infections in chickens. 195413131181
the effects of protozoan parasite eimeria tenella on the ability of the chicken to do muscular work when its muscles are stimulated directly and indirectly. 195413202011
invasion of the cecal mucosa of the chicken by sporozoites of eimeria tenella. 195913665460
nitrofuran production efficiency in chickens.two nitrofuran feed additives, 0.011% nihydrazone and a combination of 0.0055% nitrofurazone and 0.0008% furazolidone, improved weight gains and feed conversions in chickens with "air sac infection." both nitrofurans caused a significant reduction in the total chickens condemned at the dressing plant from this disease, but nihydrazone gave the best results. nihydrazone(*), a new nitrofuran feed additive for chickens, was found by wolfgang et al. (1) to be effective against coccidiosis due to eim ...196217649352
immunity to eimeria tenella in young fowls (gallus domesticus). 196214486445
the role of the bursa of fabricius in adrenal response and mortality due to eimeria tenella infections in the chicken. 196213877924
attempts to induce a passive immunity to eimeria tenella in young fowls (gallus domesticus). 196313943393
behavior of invasive stages of eimeria tenella in the immune fowl (gallus domesticus). 196314053105
active and passive immunization of chickens against intravenously induced infections of eimeria tenella. 196514296056
serum lysins in chickens infected with eimeria tenella. 196514339385
eimeria tenella: cultivation of the asexual stages in cultured animal cells.eimeria tenella, an intracellular protozoan parasite of the cecal epithelium of chickens, developed asexually in monolayer cultures of mammalian fibroblasts, mammalian epithelial cells, and avian fibroblasts mintained under various mediums at 41 degrees c. sexual stages of the parasite were not seen. established cell lines and secondary cell cultures were equally suitable for cultivation of the parasite.19655844081
effect of chicken antiserum and tissue extracts on the oocysts, sporozoites, and merozoites of eimeria tenella and e. acervulina. 19655857290
experiments with eimeria tenella railliet and lucet, 1891, in chickens by parenteral routes of infection. 19665977576
effects of the immune chicken on the endogenous stages of eimeria tenella. 19676017227
drug resistance in eimeria tenella. vii. acriflavine-mediated loss of resistance to amprolium. 19685757662
the stability of resistance to glycarbylamide and 2-chloro-4-nitrobenzamide in eimeria tenella. 19685651191
excystation of the sporozoites of eimeria tenella in apparently unbroken oocysts in the chicken. 19685719066
duration of acquired immunity of the chicken to eimeria tenella infection. 19685647102
[the fine structure of the macrogametes of the chicken coccidium, eimeria tenella]. 19695384759
a comparison of two laboratory strains of eimeria tenella. 19695307892
eimeria tenella: packed blood cell volume, hemoglobin, and serum proteins of chickens correlated with the immune state. 19695362312
a comparison of two laboratory strains of eimeria tenella. 19695374715
effect on mortality of semipurified diets versus natural feedstuffs fed to chickens infected with eimeria tenella. 19695796729
tissue and organ specificity of eimeria tenella (railliet and lucet, 1891) fantham, 1909 in cecectomized chickens. 19695796872
gametogony of eimeria tenella (coccidia) in cell cultures.mature male and female gametocytes of eimeria tenella, a coccidium of the chicken ceca, developed in primary cultures of chick embryonic kidney cells inoculated with sporozoites. immature gametocytes appeared in the cultures after approximately 144 hours of incubation at 41 degrees c. mature micro-and macrogametes were present from 160 to 190 hours after inoculation.19695812570
drug resistance in eimeria tenella. 8. the influence of quinacrine hydrochloride on development of resistance to glycarbylamide. 19695812638
observations on eimeria tenella in feces of inoculated chickens. 19695343463
observations on the growth of eimeria tenella in cultured cells from the parasitized chorioallantoic membranes of the developing chick embryo. 19694901869
effect of two levels of buquinolate on endogenous development and oocyst suppression of eimeria tenella. 19705485480
development (schizogony) of eimeria tenella in the liver of chickens treated with corticosteroid. 19705409987
carbohydrate stores in chickens infected with eimeria tenella. 19705483914
some factors affecting the severity of infection with eimeria tenella in chicken embryos. 19705445541
embryonic response to eimeria tenella infection. 19705459048
cellular aspects of the resistance of chickens to eimeria tenella infections. 19705420330
efficacy of decoquinate against eleven strains of eimeria tenella and development of a decoquinate-resistant strain. 19715582058
drug resistance in eimeria tenella. x. restoration of drug sensitivity following exposure of resistant strains to other coccidiostats. 19715553455
hematocrits, growth, and mortality in surgically bursectomized and thymectomized chickens iected with eimeria tenella. 19715549388
acquired immunity of buquinolate-medicated chickens to eimeria tenella infection. 19715094394
comparative development of eimeria tenella in primary cultures of kidney cells from the chicken, pheasant, partridge, and turkey. 19715167883
[study of the fluorescent antibodies in experimental coccidiosis in chickens caused by eimeria tenella]. 19714949105
sexual differentiation of merozoites of eimeria tenella. 19724116918
fine structural changes in eimeria tenella, from infections in chick embryos and chickens, after exposure to the anticoccidial drug robenidene. 19724680540
[zn65 metabolism in chickens with coccidiosis caused by eimeria tenella]. 19725086342
[blood sugar levels in experimental coccidial infections in domestic chickens (gallus domesticus). contribution to the detrimental effects of eimeria tenella]. 19725048448
eimeria tenella in monoflora and diflora chicks. 19724339492
migration inhibition test of splenic cells of chickens infected with eimeria tenella. 19734687493
the effect of histomonas meleagridis on the development of eimeria tenella. 19734737341
the effect of eimeria tenella infection and testosterone treatment on the weight of the bursa of fabricius in young chickens. 19734754020
effects of different infection rates on the oocyst production of eimeria acervulina or eimeria tenella in the chicken. 19734761768
the immunity arising from continuous low-level infection with eimeria tenella. 19734761772
[coccidiosis of cecum induced in gallus domesticus (l.) by eimeria tenella (raillet et lucet, 1891) fantham, 1909. i. etiology and pathogenesis]. 19734768032
[coccidiosis of cecum caused in gallus gallus domesticus (l.) by eimeria tenella (raillet et lucet, 1891) fantham, 1909. ii. pathology, epizootiology and immunological phenomena]. 19734768033
endogenous stages of a 'chick embryo-adapted' strain of eimeria tenella. 19734786834
[mechanism of acquired anticoccidia immunity. studies of caecal coccidiosis in the chicken (eimeria tenella)]. 19734801942
the effect of dietary crude protein level on intestinal and cecal coccidiosis in chicken.the effect of interaction of crude protein level in the diet and coccidiosis of the cecum and small intestine of chicks was investigated. a total of 390 day-old chicks were divided in 36 groups of ten and six groups of five chicks each. twelve groups of ten and two groups of six chicks each were fed one of the three diets based on dietary crude protein level (16%, 20% and 24%). all diets contained an equal energy concentration. the chicks were on the appropriate diet for 15 days prior to infecti ...19734266700
coccidiosis in chickens: obligate relationship between eimeria tenella and certain species of cecal microflora in the pathogenesis of the disease. 19734355962
eimeria infection of chicken embryos: the effect of known anticoccidial drugs against e. tenella and e. mivati.the activity of nine anticoccidial drugs was investigated against eimeria infections of chicken embryos. with eimeria tenella, three parameters were used to assess the antiparasitic effects (a) mortality (b) focal lesions on the chorioallantoic membrane (cam) and (c) oocyst production. anticoccidial drugs against e. mivati were evaluated by estimating oocyst production only. only three of the anticoccidials tested were found to have high activity when measured by all of the above criteria. all o ...197318777390
further studies on the pathogenicity and immunogenicity of an embryo-adapted strain of eimeria tenella.the pathogenicity, immunogenicity and reproduction of a strain of e. tenella, serially passed in embryos was studied. a strain which had completed 62 embryo passages no longer regained pathogenicity after nine passages in chickens. the reproduction of the strain in chickens, judged by oocyst production was poor, but increased after nine serial passages in chickens. the embryo passaged strain was immunogenic and a single dose of oocysts gave substantial protection against challenge with the patho ...197418777281
immune responses in infections with coccidia: macrophage activity.peritoneal exudate cells from chickens immunized with two species of coccidia, eimeria tenella or eimeria maxima, were examined for their capacity to phagocytose stages of the parasite in vitro. true phagocytosis of the sporozoite stage is difficult to estimate because of its ability to invade cells, but may be evaluated by comparison with control suspensions. peak activity (compared with cells from coccidia-free chickens) was found 3 to 5 weeks after the first inoulum of oocysts of e. tenella, ...19744426710
drug resistance in eimeria tenella: xi. comparative response to amprolium of five isolants derived from a resistant strain. 19744430951
[intraspecies variability in eimeria tenella]. 19744449655
[effect of coccidial infection on acetylcholine-induced contraction of the digestive tract in chickens. i. eimeria tenella and e. acervulina infection (author's transl)]. 19744474562
[increase in the dna quantity in the cell nuclei of the intestinal caeca of the chick during the development in them of second-generation eimeria tenella schizonts]. 19744608988
[fe59 absorption in the intestines of chicks with coccidiosis caused by eimeria tenella]. 19744829588
[phosphatase activity of the small intestine mucous membrane of chickens following single and triple inoculation with eimeria tenella coccidia]. 19744829589
genetic transfer of anticoccidial drug resistance in eimeria tenella. 19744436755
[change in the amount of serum lecithin in chickens with experimental coccidiosis (eimeria tenella, e. mitis)]. 19744456275
[the intensity of c-14-glycine incorporation into the proteins of different organs of chickens with coccidiosis caused by eimeria tenella]. 197546602
septamycin, a polyether antibiotic. taxonomy, fermentation, isolation and characterization.septamycin is a metal complexing polyether antibiotic produced by a strain of streptomyces hygroscopicus nrrl 5678. the metabolite, a monocarboxylic acid, was isolated as the sodium salt c48h81nao16. the crystal structure and absolute configuration were established by x-ray analysis of the p-bromophenacyl derivative. septamycin has a thirty-carbon backbone and contains seven heterocyclic rings. supported by direct comparison septamycin proved to be identical with antibiotic a28695 a isolated fro ...1975172482
reduction of clostridium perfringens by feed additive antibiotics in the ceca of chickens infected with eimeria tenella.two experiments were performed ot investigate the effect of feed additive antibiotics on clostridium perfringens and enterobacteriaceae in the ceca of chickens infected with eimeria tenella. in the first experiment, chickens were continuously fed rations containing thiopeptin, 2 mg./kg.; bacitracin, 20 mg./kg.; penicillin, 12 mg./kg.; or chlortetracycline, 22 mg./kg. one day after antibiotic feed was given, each bird received an oral inoculation of 30,000 e. tenella oocysts. the growth of c. per ...1975169521
lerbek, a synergistic mixture of methyl benzoquate and clopidol for the prevention of chicken coccidiosis.methyl benzoquate at 20 ppm or clopidol at 250 ppm in the diet show true coccidiostatic activity in infections with eimeria tenella in the chick. lerbek, a synergistic mixture yielding 8-35 ppm methyl benzoquate and 100 ppm clopidol, produced a partially coccidiocidal effect; relapses following restricted periods of medication were less severe, and suppression of parasite development following delayed medication was quicker and more effective with either component of the mixture used alone.19751055985
dihydrofolate reductase from eimeria tenella: rationalization of chemotherapeutic efficacy of pyrimethamine.dihydrofolate reductase activity of 0.2 nmole of dihydrofolate reduced/min/mg protein was detected in crude extracts of unsporulated oocysts of eimeria tenella. the enzyme was purified by a combination of affinity and ion-exchange chromatography. its molecular weight was estimated as 240,000 daltons. an anticoccidial drug pyrimethamine is a potent inhibitor of the activity of e. tenella dihydrofolate reductase (ki = 3 nm), but it is less effective an inhibitor of dihydrofolate reductase from chi ...19751059772
preparation and purification of merozoites of eimeria tenella.second-generation merozoites of eimeria tenella were obtained from both infected cecal tissue and infected chorioallantoic membranes of embryonated eggs. the merozoites were harvested from the tissue by incubation with hyaluronidase, yielding approximately 4 times 10(7) merozoites per cecum and 3 times 10(6) merozoites per chorioallantoic membrane. subsequent purification of the merozoites by density centrifugation and glass bead filtration resulted in a 54% overall yield and a final preparation ...19751165553
eimeria tenella in gnotobiotic chickens: hematocrit, weight change, cecal pathology, and mortality.on days 5 to 8 after oral inoculation with 200,000 eimeria tenella oocysts, the mean hematocrits of bacteria-free, bacillus cereus-monoflora and conventional chickens were equally reduced below control values. weight loss was first observed in bacteria-free and monoflora fowl between days 4 and 5 after e. tenella inoculation, whereas conventional fowl initially displayed weight loss between days 3 and 4. gross cecal lesion scores and total mortality of 4 experiments were not significantly differ ...1975805225
sequential use of coccidiostats: effect on development by eimeria tenella of resistance to amprolium, nicarbazin, unistat, and zoalene.a strain of the cecal coccidian of chickens, eimeria tenella, was propagated serially in chickens fed mash containing amprolium, nicarbazin, unistat, or zoalene. each group of chickens received a different coccidiostat on a rotating basis. the strain was propagated through 40 groups of chickens; thus, the strain was intermittently exposed 10 times to each coccidiostat. the end product of this simulated shuttle program of prophylactic anticoccidial medication was a strain resistant to three of th ...19751164311
ultrastructure of cytoplasmic and nuclear changes in eimeria tenella during first-generation schizogony in cell culture.eimeria tenella sporozoites were inoculated into primary cultures of chick kidney cells. cells fixed from 1 1/2 to 54 hr later were examined with the electron microscope. at 1 1/2 and 24 hr, most intracellular sporozoites were fusiform and retained organelles typical of extracellular sporozoites. however, at 35 hr, rounded trophozoites were present without these structures; only a refractile body, nucleus, mitochondria, and endoplasmic reticulum remained. binucleate parasites were also present a ...19751167908
studies of the mitochondria from eimeria tenella and inhibition of the electron transport by quinolone coccidiostats.intact but fragile mitochondria were isolated from unsporulated oocysts of eimeria tenella. the mitochondria respired in response to succinate, malate plus pyruvate, and l-ascorbate at rates of 1.00, 0.40, and 0.25 mu1 o2/min/mg protein, respectively. spectrophotometric analyses of the cytochromes in mitochondria and whole oocysts revealed b-type and o-type cytochromes, at roughly similar levels, but no cytochrome c could be detected. the mitochondrial respiration was inhibited by cyanide, azide ...19751171697
interaction of aflatoxin with eimeria tenella infection and monensin in young broiler chickens.young broiler chicks inoculated with eimeria tenella and given a diet containing 2.5 mug aflatoxin/g had significantly higher mortality than birds with aflatoxicosis or coccidiosis alone or uninoculated controls. this effect was seen even when a light coccidial infection alone did not increase mortality or cause weight depression. in addition this higher mortality with the combination began earleir and occurred at a higher rate than did mortality from aflatoxin or cecal coccidiosis alone. dietar ...19751200947
[study of immunity in coccidiosis in chickens experimentally infected with marek's disease].the immunity was studied against coccidiosis in birds that had preliminary been infected with marek's disease. results showed that birds infected with marek's disease are unable to build up stable immunity against an oocyst infection of eimeria tenella. the rate of mortality due to marek's disease in birds infected with the virus of marek's disease and additionally infected with oocysts of e. tenella was higher as compared with that in birds that were infected only with the virus of marek's dise ...19751210012
scanning electron microscopy of eimeria tenella infection and subsequent repair in chicken caeca. 19751181349
eimeria tenella in chickens: development of resistance to quinolone anticoccidial drugs.the development of drug resistance by the present houghton strain of eimeria tenella to the quinolones, methyl benzoquate and buquinolate, was found to take place after a single experimental passage. the development of resistance was independent of drug selection pressure and showed cross resistance to other quinolones, but not to amprolium and robenidine. when the weybridge, beltsville and elberfeld strains of e. tenella were compared under similar laboratory conditions, the weybridge and elber ...19751058450
scanning electron microscopy of the cecal mucosa in eimeria-tenella-infected and uninfected chickens.four major types of surface conformation were observed in the ceca of uninoculated control chickens. spatulate villi were found in the cecal neck region, low ridges in the region where the neck expands, protruding collarlike structures in the mid cecal pouch, and flattened collars in the distal portion. in ceca infected with eimeria tenella, there was some erosion and sloughing of the mucosal cells. these lesions were slight in the neck region, more severe in the dilated portion, most severe in ...19751156258
effect of feed additive antibiotics on chickens infected with eimeria tenella.six experiments were carried out to study the effect of feed additive antibiotics on body weight, mortality and oocyst production in chickens infected with coccidiostat-susceptible or -resistant strain of e. tenella. levels of antibiotic and coccidiostat in fed (mg./kg.) were: thiopeptin, 2; zinc bacitracin, 20; penicillin, 12; chlortetracycline, 22; amprolium plus ethopabate, 125 plus 8; clopidol, 125. all experiments included 7 groups; 2 of these groups were uninfected and infected controls, a ...19751161694
response of chickens with genetically different hemoglobin types to infection with eimeria tenella and mechanical bleeding.the hematological and body-weight responses of chickens with mutant and normal hemoglobin types were compared under conditions of hematopoietic stress from coccidiosis infection as well as blood loss from mechanical bleeding. a dose of 100,000 eimeria tenella oocysts caused a highly significant decrease (about 30%) in the packed cell volume, resulting in a severe anemia in all hemoglobin types. hematological response to the anemia produced by the coccidiosis was similar for all three hemoglobin ...19751200949
relative value of oocyst counts in evaluating anticoccidial activity.birds medicated with roxarsone and in another experiment with zoalene in the feed produced higher oocysts counts than unmedicated control birds receiving the same oocyst dose of eimeria tenella or a mixture of six species (e. tenella, e. necatrix, e. brunetti, e. maxima, e. acervulina, and e. mitvati). these experiments confirm the conclusion that oocyst counts constitute an unsatisfactory and unreliable parameter for judging effectiveness of an anticoccidial even though such increases are a rel ...19751200950
[study of the immunogenic capacity of the oocytes of e. tenella following irradiation with gamma rays].studied was the immunizing capacity of eimeria tenella oocysts, treated with gamma rays at the rate of 6000 r, in 10- and 20-day-old chickens. the oocysts sporulated after treatment. applied at the rate of 50,000 r they showed lower virulence and were capable of inducing resistance to reinfection with nonirradiated oocysts at rates that were three times as much. following reinfection some birds manifested subclinical coccidiosis but survived. this showed that the immunization with oocysts that h ...19751239853
cecal coccidiosis in poultry as affected by prior exposure to aflatoxin b1.young new hampshire and broiler chickens were given feed containing 2 concentrations of aflatoxin b1 (0.2 or 2.0 ppm). the larger concentration caused severe toxicosis and death in the new hampshire chicks, but did not cause gross signs in the broiler chicks. however, temporary stunting was seen on both new hampshire and broiler chicks during periods of aflatoxin feeding, along with persisting decreased weight gains in the broiler chicks; the latter apparently recovered during the next 21 days o ...19761247200
growth of eimeria tenella in vitro in macrophages from chicken peritoneal exudates. 19761258530
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