TitleAbstractYear(sorted ascending)
continuous phenothiazine therapy of dogs artificially infected with ancylostoma caninum. 195613302654
comparative morphology of ancylostoma tubaeforme (zeder, 1800) and ancylostoma caninum (ercolani, 1859). 196214017192
effect of age of the dog on immunogenic efficiency of double vaccination with x-irradiated ancylostoma caninum larvae. 19655882555
effect of thiabendazole on ancylostoma caninum.thiabendazole inhibits nematode development before the third stage is reached. the minimum effective concentration is 0.1 microgram/ml during the first 48 hours of development and 1.0 microgram/ml at 72 hours of development. the drug has no effect on the third stage but is again effective on larvae that have undergone 72 hours of development in the intestine of the specific host (dog). increasing concentrations of the drug seem to be necessary to kill the larvae as the organism progresses in dev ...196511850956
anthelmintic activity of thenium p-chlorobenzene sulfonate against various stages of ancylostoma caninum in young dogs. 19665913041
transfer of immunity to ancylostoma caninum infection in pups by serum and lymphoid cells. 19676020124
immunity of dogs to ancylostoma braziliense infection following vaccination with x-irradiated ancylostoma caninum larvae. 19676068075
[the influence of ultraviolet irradiation upon the development and infectivity of hookworm larvae]the eggs and rhabditoid larvae of canine hookworm were irradiated with ultraviolet rays for one hour at a distance of 10, 20, 30, and 40 cm. the infective stage larvae of the same parasites were irradiated for l, 3, 5 and 14 hours from the same distances. the infective larvae were also exposed under direct sunlight for l, 2, 3 and 4 hours. parasites: ancylostoma caninum was used. eggs were collected in vitro from female adult worms. the worms were kept at 37 degrees c in petri-dish filled with k ...196812913550
fine structure of the intestine of the nematodes, ancylostoma caninum and phocanema decipiens. 19684915918
transmammary passage of ancylostoma caninum larvae in dogs. 19685761146
control of ancylostoma caninum in the dog with cthiabendazole. 19705505148
infectivity of ancylostoma caninum larvae from canine milk. 19705469538
biochemistry of the dog hookworm. ii. nature and origin of the excreted fatty acids. 19705419452
ancylostoma caninum: uptake of 14c-glucose in vitro. 19705504481
efficacy of a hookworm (ancylostoma caninum) vaccine for dogs. 19734721752
estimation of blood loss caused by ancylostoma caninum in dogs using 51-cr-labelled red cells. 19751145238
survival of ancylostoma caninum on bluegrass pasture.the survival of infective larvae of ancylostoma caninum on outdoor grass plots was studied in 40 experiments over 1 year. weather data were collected over the period. mean larval survival from august to early november was 24 days (range 1 to 49), from december through february was 0 days, and from march to mid-august was 6.6 days (range 0 to 21). moderate to high temperatures and substantial rainfall favored larval survival; low temperatures and rainfall favored larval destruction.19751138040
[reactivation of inhibited larvae of ancylostoma caninum. effect of estradiol and progesterone]. 19761015057
changes in hookworm distribution in surinam.during the months may-july, 1974, a follow-up investigation was carried out on hookworm infections in dogs and cats in order to study changes in the hookworm distribution in surinam since 1967. fifty-two cats and 152 dogs were examined for the presence of helminths in the oesophagus, small intestine, coecum and heart. in total 15,942 helminths were isolated; most of these (14,006) were hookworms belonging to the species ancylostoma caninum, a. tubaeforme, a. ceylanicum and a. braziliense. the av ...1976987625
[research on intestinal parasitic diseases in dogs of the city of rome].a survey on the diffusion of intestinal parasites of dogs in the town of rome. the results of a survey on the diffusion of cestodes and nematodes in a hundred dogs in rome are reported. the dogs were subjected to fecal examinations --- using both the flottation method and the mcmaster method -- and to the post-mortem examination of the intestine. at post-mortem examination 25 dogs were found parasitized by one or more species of nematodes, 19 by one or more species of cestodes and 12 both by ces ...1977754133
spinal nematodiasis of the dog associated with ancylostoma caninum. 1977614029
[localization of adult ancylostoma caninum in the intestines of dogs with experimental ancylostomiasis]. 1977553473
[galactogenic transmission of third larvae of ancylostoma caninum ercolani 1859 (ancylostomidae) in paratenic hosts]. 1978569954
gastrointestinal helminths in dogs from a humane shelter in indiana.between january 1975 and august 1976, the alimentary tracts of 104 euthanatized dogs from a humane shelter in tippecanoe county, indiana, were examined to determine the prevalence of gastrointestinal helminths. the survey was restricted to dogs greater than 1 year old. their average age was estimated at approximately 2 years. parasitism was detected in 86.5% of the dogs examined. ancylostoma caninum was found most often (58.7%), followed by trichuris vulpis (51.9%), taenia sp (31.7%), toxocara c ...1978721684
[1st finding of the ancylostoma braziliense nematode (gómez de faria, 1910) in canis familiaris in cuba].according to the results obtained by investigators who have been devoted up to date to the study of dog helminthiases in cuba dog ancylostomiasis is produced by ancylostoma caninum. now, ancylostoma braziliense (gómez de faria, 1910) has been found in two dogs from the havana province. the knowledge of the invasion extension as well as of the intensity of infestation should wait for the exhaustive study of the collected material.1978358325
the efficacy of amidantel, a new anthelmintic, on hookworms and ascarids in dogs.amidantel is a new anthelmintic from a new chemical class with an interesting anthelmintic spectrum. in dogs amidantel is highly effective in a single oral dose of 25 mg/kg against both hookworm species, ancylostoma caninum and unicinaria stenocephala. in toxascaris leonina infected dogs a complete cure rate was achieved with a single oral dose of 50 mg/kg. similar results were obtained with 8 mg/kg administered three times per day. the most sensitive parasite to amidantel was found to be toxoca ...1979295548
gastro-intestinal helminths of domestic dogs in the republic of south africa.of the gastro-intestinal helminths found in 1 063 dogs from different parts of the country, dipylidium caninum, the most prevalent cestode, occurred in 19,7% of the animals. echinococcus granulosus was present in 10 dogs, 8 of which were from urban areas, and taenia hydatigena in 69 dogs. taemia multiceps was recovered from dogs only in the cape province and the orange free state. toxocara canis was present in 81 of the necropsies carried out on 253 dogs from the pretoria municipal area, while a ...1979575920
a comparison of the sites of acid phosphatase activity in an adult filaria, setaria sp. and in some gastro-intestinal nematodes.the histochemical localization of acid phosphatase in an adult filaria, setaria sp. obtained from the peritoneal cavity of a cow was closely examined and compared with that of adult nematodes parasitic in the host alimentary canal; special attention was paid to the intestine and body wall of the parasites. setaria sp. was found to show high acid phosphatase activity in the interchordal hypodermis of the body wall and uterine microfilariae, and similar activity is suspected to occur in the cuticl ...19807195002
[effect of various benzimidazole carbamates on somatic larvae of ancylostoma caninum ercolani 1859 (ancylostomidae) and toxacara canis werner 1782 (anisakidae). 2. studies of pregnant bitches]. 19817293557
[an epidemiological study on zoonoses in korea]helminthic zoonoses are of significant importance to the public health and to the socioeconomic consequences especially in lost-meat, animal products and animal labor. for past several decades in korea, it has been recognized that endoparasitic infections among domestic animals are extremely common and many of the helminth parasites of man have been acquired from, or are shared with domestic animals. however, there was no survey of a nationwide scale on the prevalence of animal helminthiasis; an ...198112902720
effect of febantel against ancylostoma caninum and trichuris vulpis infections in dogs.febantel was administered as a 3.4% paste to 45 dogs infected with 1 or more nematode species, which included ancylostoma caninum and trichuris vulpis. dosage levels of 5, 10, or 15 mg/kg of body weight daily for 3 consecutive days for a total of 15, 30, or 45 mg/kg were administered. at 15 mg/kg, all dogs were completely cleared of all nematode and cestode infections, including a caninum, t vulpis, uncinaria stenocephala, toxocara canis, toxascaris leonina, taenia sp, and dipylidium caninum, ex ...19827103181
anthelmintic activity of closantel against ancylostoma caninum in dogs.the efficacy and minimum therapeutic dose of closantel, an injectable salicylanilide anthelmintic, was evaluated on adult ancylostoma caninum. doses of 7.5 and 10 mg/kg had a marked anthelmintic effect on adult stages, removing 99 and 98%, respectively. a second experiment tested the efficacy of closantel against hypobiotic larval stages of a. caninum. a dose of 20 mg/kg did not affect the abundance of arrested hookworm larvae or prevent their subsequent development, but it may have inhibited th ...19827119989
the function of microtubules during spermatogenesis of ancylostoma caninum.ancylostoma caninum spermatogonia appeared as unspecialized cells with large nuclei and little cytoplasm when examined by electron microscopy. mitochondria and ribosomes were numerous but endoplasmic reticulum of either the rough or smooth variety was rarely observed. microtubules were abundant but were mostly concentrated in areas where the cells connected with a central cytoplasmic core, or rachis. microtubules present elsewhere in the cytoplasm were not associated with any particular organell ...19827131187
anthelmintic effect of febantel/praziquantel paste in dogs and cats.a paste formulation of 3.4% febantel and 0.34% praziquantel was given in soft food at a rate of 0.29 g/kg of body weight, once daily for 3 days to dogs and cats. eleven of 12 dogs were naturally infected with ancylostoma caninum, 10 with trichuris vulpis, 2 with toxocara canis, 5 with taenia sp, and 3 with dirofilaria immitis. ten of 11 cats were naturally infected with toxocara cati, 2 with ancylostoma tubaeforme, 3 with taenia sp, 5 with capillaria aerophila, and 1 with paragonimus kellicotti. ...19846703448
dose-titration studies of ivermectin against experimental ancylostoma caninum and uncinaria stenocephala infections.dose-titration trials of ivermectin were conducted on pups with dual experimental infections of 4th-stage larvae or adult ancylostoma caninum and uncinaria stenocephala. ivermectin was administered orally or subcutaneously at dosages of 0.006, 0.012, or 0.024 mg/kg of body weight. maximal or near maximal (greater than or equal to 96% to 100%) anthelmintic effect was observed for both stages of development for each hookworm species by either route of administration at a dosage of 0.024 mg/kg. res ...19853839115
prenatal and lactational transmission of toxocara canis and ancylostoma caninum: experimental infection of the bitch before pregnancy. 19853980144
field trials of the anthelmintic efficacy of nitroscanate and mebendazole in dogs.the efficacies of nitroscanate and mebendazole against nematodes and dipylidium caninum were compared by the examination of the faeces of 155 dogs. in unweaned puppies nitroscanate acted significantly faster and was significantly more effective than mebendazole against toxocara canis. in adult dogs, both drugs had a low efficacy against trichuris vulpis but a similarly good efficacy against other nematodes, with a tendency for nitroscanate to be more effective in reducing the prevalence of ancyl ...19902309388
effect of milbemycin oxime against ancylostoma caninum in dogs with naturally acquired infection.twenty-six mixed-breed (14 males, 12 females) dogs were used in a double-blind study to evaluate the effect of milbemycin oxime against naturally acquired infection with ancylostoma caninum. dogs were ranked and paired, on the basis of number of hookworm eggs/g of feces, and treatment was randomly assigned. each dog was given either the study drug or placebo (1 tablet/11.4 kg [0.5 mg/kg] of body weight). eggs per gram of feces enumeration was done on days 3 and 7 after treatment, and dogs were e ...19911883101
anthelmintic activity of paraherquamide in dogs.paraherquamide, an oxindole alkaloid metabolite of penicillium paraherquei and penicillium charlesii, was tested against the common gastrointestinal nematodes of dogs at a single oral dosage of 0.5, 1.0, or 2.0 mg kg-1. efficacy was poor (less than 85%) against ancylostoma caninum, uncinaria stenocephala, toxascaris leonina, trichuris vulpis, and strongyloides stercoralis at the low- and mid-dosage levels. at the high dosage level, good efficacy (91%) was observed only against s. stercoralis. ad ...19911788941
ancylostoma caninum: reduced glutathione stimulates feeding by third-stage infective larvae.the resumption of feeding in vitro has been proposed as an indicator of the reactivation of development by arrested third-stage hookworm larvae. the tripeptide glutathione was tested for its ability to induce in vitro feeding by third-stage infective larvae of the canine hookworm ancylostoma caninum. reduced glutathione, but not oxidized glutathione, stimulated larval feeding in a specific, concentration-dependent manner. feeding began at 5-10 mm, and reached a plateau at 25-50 mm. incubation in ...19921639163
[detection of intestinal parasites from dogs in tochigi-city in 1979 and 1991].to clarify whether sanitary and hygienic conditions surrounding humans and pet animals have improved or not, we examined feces from dogs for intestinal parasites in tochigi in 1979 and 1991. intestinal parasites were detected from 109 of the 262 dogs (41.9%) in 1979 and 86 of the 260 dogs (32.8%) in 1991. among the parasites. ancylostoma caninum, tirchuris vulpis and toxocara canis were most commonly detected, and their detection rates were higher in 1979. on the contrary, dipylidium caninum, st ...19921293225
intestinal helminths of public health importance in dogs in a survey of intestinal canine zoonotic helminths in nairobi, 156 dogs were autopsied. of these, 10% were infected with echinococcus granulosus, 88% with ancylostoma caninum, 45% with dipylidium caninum and 3% with toxocara canis. all the infected dogs with e. granulosus originated from around abottoirs in dagoretti. the risk of infection in man with hydatid disease is considered to be high around dagoretti and control measures are recommended.19938187655
the ecology of animal parasitic nematodes in endemic areas of jos, nigeria.a survey involving 3418 faecal samples collected from three areas of heavy human and animal activities in jos, nigeria showed that 2354 (68.9%) of the samples harboured various parasitic nematodes of man and animals. altogether, twelve species of parasitic nematodes were encountered. five of these, namely: ascaris lumbricoides, ancylostoma duodenale, necator americanus, trichuris trichiura and strongyloides stercoralis infect man while five others: trichostrongylus probolurus, t. colubriformis, ...19938334456
dog hookworm: a cause of eosinophilic enterocolitis in humans. 19947877002
investigations into the efficacy of doramectin on reactivated somatic larvae of ancylostoma caninum ercolani 1859 (ancylostomatidae) in pregnant bitches.the aim of this investigation was to examine whether reactivated somatic ancylostoma caninum larvae can be eliminated by the administration of doramectin to pregnant bitches. four pregnant bitches experimentally infected with 20,000 third-stage larvae of a. caninum were treated subcutaneously with 1 mg doramectin per kg body weight on day 55 of the pregnancy (5-8 days before parturition). another four experimentally infected pregnant bitches served as controls. the single doramectin treatment co ...19947740860
immunologic incrimination of ancylostoma caninum as a human enteric northeastern australia, the incidence of human eosinophilic enteritis (ee) and unexplained abdominal pain with peripheral blood eosinophilia (pe) appear to be exceptionally high. because adults of the common dog hookworm, ancylostoma caninum, were found in situ in several cases, we compared specific antibody responses in patients with ee or pe with those of individuals from various control groups. sera were obtained from three patients with confirmed dog hookworm infection, 25 patients with e ...19948304575
amplification and characterization of cysteine proteinase genes from order to isolate proteinase genes from parasitic nematodes by polymerase chain reaction (pcr) techniques, we employed a pair of consensus oligonucleotide primers designed to anneal to the active site cysteine (primer ncpc) and asparagine (primer ncpn) coding regions of cysteine proteinases. the primers were biased toward the nucleotide and codon usages of cysteine proteinase genes of nematodes and were based on the consensus nucleotide sequences flanking the active site residues of genes from ...19958525283
comparison of the efficacies of three heartworm preventives against experimentally induced infections with ancylostoma caninum and toxocara canis in pups.forty 11- to 12-week-old helminth-naive beagles were categorized by sex and weight and randomly assigned to 4 treatment groups (group 1, ivermectin/pyrantel pamoate; group 2, milbemycin oxime; group 3, untreated control; group 4, diethylcarbamazine/oxibendazole). each pup was inoculated po with approximately 100 infective ancylostoma caninum larvae and 100 larvated toxocara canis eggs on day 0, and repeatedly at 7-day intervals thereafter until day 56. administration of anthelmintics also began ...19957782242
an investigation into the health status and diseases of wild dogs (lycaon pictus) in the kruger national park.many factors have been cited as possible reasons for the decline in the number of wild dogs (lycaon pictus), but few studies have provided supportive data. between 1990 and 1993, the dynamics of 10 wild dog packs in the southern district of the kruger national park in south africa were monitored. casual observations of the causes of disease and mortality in the entire population were also recorded. during the same period, 46 wild dogs were immobilised, weighed, and subjected to physical examinat ...19957629782
long-term survey on intestinal nematode and cestode infections in stray puppies ibaraki prefecture.we conducted the survey on intestinal nematode, mainly toxocara canis, and cestode infections in stray puppies aged less than 5 months in ibaraki prefecture for 8 years from 1988 to 1995. the rate of t. canis infection stayed almost unchanged for the 8 years and ranged from 72.2 to 85.4%. of the total 916 dogs, 732 (79.9%) harboured with t. canis. the average rates of other helminthic infections showed 24.6 (diphylidium caninum), 2.5 (trichuris vulpis), 1.2 (ancylostoma caninum) and 0.7% (spirom ...19979300373
anthelmintic efficacy of oxibendazole against some important nematodes in dogs and cats.the anthelmintic efficacy and safety of the oxibendazole component in a combination oxibendazole-niclosamide paste were investigated in dogs and cats and in litters of pups with naturally acquired nematode infections. a single dose of 15 mg oxibendazole/kg body weight given to 70 dogs and to 29 cats reduced faecal worm egg counts (epg) by 97.6% for toxocara canis, 95.7% for trichuris vulpis, 94.6% for ancylostoma caninum, and 100% for toxascaris leonina. in cats, 96.7% efficacy was demonstrated ...19989563164
a recombinant protein disulfide isomerase homologue from ancylostoma caninum.the objective of this study was to characterize a recombinant antigen of ancylostoma caninum that had been identified by immunoscreening with selected antisera as described elsewhere. in vitro expression of clone ac38-1 produced a protein with an apparent molecular mass of approximately 38 kda, which reacted in western blots with the antiserum from rabbits experimentally infected with l3 and also with affinity-purified antibodies against hydrophilic proteins of the cephalic glands obtained from ...19989766908
anthelmintic efficacy against tissue-arrested larvae of ancylostoma caninum in murine hosts.third-stage larvae of the major human and canine ancylostoma hookworm species have the capacity to undergo developmental arrest in the somatic tissues of an infected host. arrested larvae reactivate at opportune periods such as pregnancy, which results in the transmammary transmission of infection to the nursing neonates. using murine paratenic hosts to focus specifically on tissue-arrested stages of ancylostoma caninum, the present study found that neither recommended nor elevated doses of comm ...19989920326
helminth parasites of dogs from two resource-limited communities in south africa.biological samples were collected from dogs in resource-limited communities in the north-west and gauteng provinces of south africa to assess the prevalence of helminth parasitism. these samples included adhesive tape peri-anal skin swabs and fresh faecal samples for helminth examination, and thick and thin blood films (smears) and whole-blood samples in anticoagulant for examination of filarial nematode microfilariae and haemoprotozoa. the eggs of ancylostoma caninum, toxocara canis, toxascaris ...199910855829
evaluation of the role of ancylostoma caninum in humans as a cause of acute and recurrent abdominal pain.ancylostoma caninum is responsible for cases with eosinophilic enteritis (ee) and unexplained abdominal pain with peripheral eosinophilia in man. ninety-five patients with obscure acute or recurrent abdominal pain and ten asymptomatic healthy parasite free were subjected to thorough history taking, clinical examination, sonography, routine laboratory investigations and serotesting by igg elisa to detect antibodies to excretory/secretory (es) antigens of adult a. caninum and by igg and igg4 weste ...199912561926
in vivo activities of the new anthelmintic depsipeptide pf 1022a is a member of a new class of cyclic depsipeptides with antiparasitic activity. following in vitro and laboratory animal studies it was tested for its anthelmintic efficacy in companion and livestock animals against a wide spectrum of intestinal nematodes and lungworms. studies were carried out in rats, dogs, horses, sheep, and cattle. animals were either naturally or experimentally infested. the efficacy of pf 1022a was investigated against the following parasite species: strongyloides ...200010726989
host specificity in blood feeding parasites: a defining contribution by haemoglobin-degrading enzymes?a hypothesis is presented that proposes that the compatibility between species-specific variants of haemoglobin-degrading proteases of blood-feeding parasites (e.g. hookworms, schistosomes, malarial parasites, etc.), and their natural substrates, i.e. haemoglobins from diverse species of mammals, has influenced to evolution of the host range of these parasites. support for the hypothesis was drawn from molecular modelling studies of the three dimensional structure of an aspartic protease, acasp, ...200010856514
antithrombotic efficacy of single subcutaneous administration of a recombinant nematode anticoagulant peptide (rnap5) in a canine model of coronary artery thrombolysis.we examined the adjunctive benefit of recombinant nematode anticoagulant peptide (rnap5), a factor xa inhibitor, in a canine model of recombinant (rt)-pa-induced thrombolysis. in anesthetized dogs, a stable occlusive thrombus was formed by electrolytic injury of the vessel wall, after which the animals were administered rt-pa (1.44 mg/kg, i.v.) and rnap5 (0.1 mg/kg, s.c.: n=13), or rt-pa plus vehicle (1-2 ml, s.c.; n=13). hemodynamic and coagulation parameters were monitored for 360 minutes. sin ...200010899352
ancylostoma caninum: the finger cell neurons mediate thermotactic behavior by infective larvae of the dog hookworm.bhopale, v. m., kupprion, e. k., ashton, f. t., boston, r., and schad, g. a. 2001. ancylostoma caninum: the finger cell neurons mediate thermotactic behavior by infective larvae of the dog hookworm. experimental parasitology 97, 70-76. in the amphids (anteriorly positioned, paired sensilla) of the free-living nematode caenorhabditis elegans, the so-called finger cells (afd), a pair of neurons, each of which ends in a cluster of microvilli-like projections, are known to be the primary thermorecep ...200111281703
antibodies to selected canine pathogens and infestation with intestinal helminths in golden jackals (canis aureus) in israel.blood and fecal samples, collected from 46 healthy adult free-ranging golden jackals captured in two different locations in israel, were examined. a serological study was conducted to investigate the prevalence of circulating antibodies reacting with four common canine pathogens: canine distemper virus (cdv), canine parvovirus (cpv), ehrlichia canis and leishmania infantum. faecal flotation and haematological tests were also performed. the seroprevalence of cpv, e. canis, cdv, and l. infantum we ...200111409931
immune-mediated haemolytic anaemia: possible association with ancylostoma caninum infection in three dogs.immune-mediated haemolytic anaemia (imha) may be primary or secondary. in primary imha, no underlying cause can be found, whereas secondary imha is triggered by an underlying cause, such as neoplasia, infectious diseases, or drugs. this paper describes 3 dogs with typical signs of imha that was possibly associated with the intestinal parasite ancylostoma caninum. as intestinal helminths can be difficult to diagnose on faecal examination, it would be pertinent to perform multiple faecal examinati ...200111563722
one confirmed and six suspected cases of cutaneous larva migrans caused by overseas infection with dog hookworm larvae.cutaneous larva migrans (clm) is characterized as creeping eruption/serpiginous erythema and/or mobile erythematous induration on the skin. in japan, gnathostoma spp. are the most well known pathogens causing clm, especially the creeping eruption type. recently, spirurina type x larvae have been added to the list of causative agents for creeping eruption in japan. here we report one confirmed and 6 suspected cases of creeping eruption caused by infection with dog hookworm larvae. the patients we ...200211890293
experimental human infection with the dog hookworm, ancylostoma investigate possible routes for human infection by the dog hookworm (ancylostoma caninum). design, setting and participant: relatively small numbers of infective larvae were administered orally and percutaneously to an informed healthy volunteer (j k l) under medical supervision, at intervals between may 1998 and may 1999.200312526725
cutaneous larva migrans: the creeping eruption.cutaneous larva migrans (clm) is the most common tropically acquired dermatosis. it is caused by hookworm larvae, which are in the feces of infected dogs and cats. the condition occurs mainly in the caribbean and new world, and anyone walking barefoot or sitting on a contaminated beach is at risk. ancylostoma braziliense and ancylostoma caninum are the most common hookworms responsible for clm. the lesions, called creeping eruptions, are characteristically erythematous, raised and vesicular, lin ...200312953933
evaluation of the role of the asialoglycoprotein receptor in the clearance of uk-279,276 (recombinant neutrophil inhibitory factor).1. uk-279,276 or recombinant neutrophil inhibitory factor (rnif) is a glycoprotein that has been investigated as an intravenous treatment for stroke. previous data indicate that the asialoglycoprotein receptor (asgpr) in the liver might have a role in the uptake and clearance of uk-279,276 from plasma in rats and dogs. 2. biliary elimination of sialo uk-279,276 can be inhibited by the co-administration of asialo fetuin, a known substrate for asgpr. these data are in keeping with sialo uk-279,276 ...200314514443
prevalence of dogs with intestinal parasites in tochigi, japan in 1979, 1991 and 2002.a total of 772 canine fecal specimens were collected in tochigi in 1979, 1991 and 2001. the frequency of dogs that were kept indoor in 2002 (72.8%) was significantly higher than that for 1979 (21.2%, p < 0.001) and 1991 (40.6%, p < 0.01). the frequency of parasitized dogs in 2002 (18.8%) was significantly lower than that for 1979 (41.9%, p < 0.01). the findings of this study confirm the declining trend in japan in the prevalence of helminth parasites in dogs, particularly ancylostoma caninum and ...200415041099
a multi-enzyme cascade of hemoglobin proteolysis in the intestine of blood-feeding hookworms.blood-feeding pathogens digest hemoglobin (hb) as a source of nutrition, but little is known about this process in multicellular parasites. the intestinal brush border membrane of the canine hookworm, ancylostoma caninum, contains aspartic proteases (apr-1), cysteine proteases (cp-2), and metalloproteases (mep-1), the first of which is known to digest hb. we now show that hb is degraded by a multi-enzyme, synergistic cascade of proteolysis. recombinant apr-1 and cp-2, but not mep-1, digested nat ...200415199048
a pore-forming haemolysin from the hookworm, ancylostoma caninum.hookworms feed on blood, but the mechanism by which they lyse ingested erythrocytes is unknown. here we show that ancylostoma caninum, the common dog hookworm, expresses a detergent soluble, haemolytic factor. activity was identified in both adult and larval stages, was heat-stable and unaffected by the addition of protease inhibitors, metal ions, chelators and reducing agents. trypsin ablated lysis indicating that the haemolysin is a protein. a closely migrating doublet of hookworm proteins wit ...200415313129
application of a species-specific pcr-rflp to identify ancylostoma eggs directly from canine faeces.apart from their veterinary importance, the hookworms ancylostoma caninum, ancylostoma braziliense and ancylostoma caninum are also capable of causing zoonotic disease in humans. a highly sensitive and species-specific pcr-rflp technique was utilised to detect and differentiate the various canine ancylostoma spp directly from eggs in faeces. this technique was utilised to screen 101 canine faecal samples from parasite endemic tea growing communities in assam, india, as part as an ongoing epidemi ...200415325050
gene expression profiles associated with the transition to parasitism in ancylostoma caninum larvae.ancylostoma caninum is a common canine parasite responsible for anemia and death in infected dogs. gene expression profiling was used to investigate molecular differences between two different forms of the third larval stage (l3s): infective free-living larvae and in vitro serum-stimulated larvae that mimic the initial stages of parasitism of a host. we developed an a. caninum cdna microarray consisting of 4191 est clones, and used it to identify a set of 113 genes that are differentially regula ...200515979737
biochemical characterization and vaccine potential of a heme-binding glutathione transferase from the adult hookworm ancylostoma caninum.we report the cloning and expression of ac-gst-1, a novel glutathione s-transferase from the adult hookworm ancylostoma caninum, and its possible role in parasite blood feeding and as a vaccine target. the predicted ac-gst-1 open reading frame contains 207 amino acids (mass, 24 kda) and exhibited up to 65% amino acid identity with other nematode gsts. mrna encoding ac-gst-1 was detected in adults, eggs, and larval stages, but the protein was detected only in adult hookworm somatic extracts and e ...200516177370
[prevalence of intestinal helminths in dogs from quindío province].intestinal helminths are pathogens for domestic animals and provide a source of potential infection for humans.200516276682
a study on intestinal helminthes of dogs, foxes and jackals in the western part of iran.human infection especially with helminth parasites is an emerging health issue, as the human environment is increasingly shared with infected animals, either pets or wild life. in this survey, the intestinal content of 83 stray dogs, 22 red foxes and 10 golden jackals collected from the west azarbaijan, kordestan and kermanshah provinces in the west of iran, were studied for the presence of helminth parasites. the percentage of different species recovered from these animals is listed as follows: ...200616899340
vaccination with irradiated ancylostoma caninum third stage larvae induces a th2 protective response in dogs.while x-irradiated live parasites are not an acceptable proposition for human vaccination, they offer a ready experimental system to explore mechanisms by which immunity against hookworm infection may be induced in humans. as such, we sought to further elucidate the details of this highly protective immune response induced by the irradiated vaccine in canids, with special emphasis on the cellular aspects of the response. vaccination with irradiated l3 induced high production of antibodies and st ...200616140437
development and characterization of microsatellite markers for the canine hookworm, ancylostoma caninum.microsatellites are repetitive genomic elements that show high levels of variation and therefore provide excellent tools to study the genetics of eukaryotic organisms. hookworms are extremely common and important nematode parasites of humans and animals, causing potentially serious disease morbidity. control of hookworms in dogs is achieved by frequent treatment with anthelmintics, and in humans, anthelmintics are frequently administered in a mass-treatment community-wide approach. understanding ...200717136387
gastrointestinal nematodes in dogs from debre zeit, ethiopia.the study was conducted during the period between january 2005 and june 2006 to determine the frequency of gastrointestinal (gi) nematode infections of dogs in and around debre zeit, using qualitative and quantitative coprological (n = 100) and postmortem examinations (n = 20). by coproscopy 51% dogs were positive for different types of nematodal eggs, out of which 23.5% were with mixed infections. on necropsy 95% animals were found positive for adult parasites, of which 31.6% were showing more ...200717614203
evaluation of the transcription level of the protein disulfide isomerase in different stages from ancylostoma caninum with a real-time pcr assay.the protein disulfide isomerase (pdi) is a ubiquitous protein, which contributes in building disulfide bridges. in the work presented here, the expression of the pdi in different stages of the canine hookworm ancylostoma caninum was investigated. third-stage larvae (l3), adults, as well as serum-stimulated and hypobiotic l3 were used. for quantification of the pdi gene transcription, a real-time pcr was used establishing a hybridization probe (taqmantrade mark probes) for detection of pdi copy n ...200717762941
identification of stage-specific proteins of angiostrongylus vasorum (baillet, 1866) kamensky.sera of ten dogs infected with angiostrongylus vasorum were analyzed by immunoblotting proteins of first stage larvae (l1) and adult parasites. the molecular weights (m.w.) of the principal l1 proteins identified by igg, igm, iga, and ige were 18-118 kda and those of the adult parasite were 28-209 kda. the l1 proteins had not been recognized by igg, igm, and iga antibodies in sera of dogs naturally infected with toxocara canis, ancylostoma caninum, and dipylidium caninum, although only weakly by ...200818060430
strategies for the storage of ancylostoma caninum third-stage larvae.although cryopreservation protocols for storage of hookworm larvae have been described, the circumstances under which the technique is necessary to ensure larval survival are not well defined. the motility of infective-stage larvae (as judged by observation) and their ability to migrate through canine skin in vitro were measured over a 7-mo period in worms held at room temperature and worms that had been cryopreserved at the start of the experiment. cryopreserved worms showed motility and migrat ...200818605779
phenotypic characterization of two ancylostoma caninum isolates with different susceptibilities to the anthelmintic pyrantel.the anthelmintic pyrantel plays an important role in the control of gastrointestinal helminths of humans and domestic animals. despite the demonstration of pyrantel resistance in several helminth species over the last 20 years, the resistance mechanism remains unclear. it has been hypothesized that resistance may arise as a consequence of changes to the relative proportions of subpopulations of nicotinic acetylcholine receptors (nachrs). to test this hypothesis, we examined the responses of two ...200818710918
encroachment of echinococcus granulosus into urban areas in eastern queensland, investigate the prevalence of echinococcus granulosus in wild dogs (dingos and dingo-domestic dog hybrids) living in and around human habitation on fraser island and in townships of the maroochy shire, on queensland's sunshine coast, australia.200818673469
the mitochondrial genomes of ancylostoma caninum and bunostomum phlebotomum--two hookworms of animal health and zoonotic importance.hookworms are blood-feeding nematodes that parasitize the small intestines of many mammals, including humans and cattle. these nematodes are of major socioeconomic importance and cause disease, mainly as a consequence of anaemia (particularly in children or young animals), resulting in impaired development and sometimes deaths. studying genetic variability within and among hookworm populations is central to addressing epidemiological and ecological questions, thus assisting in the control of hoo ...200919210793
anthelmintic activity of cyclotides: in vitro studies with canine and human hookworms.hookworm infection is a leading cause of maternal and child morbidity in countries of the tropics and subtropics, as well as being an important parasite in companion-animal medicine. the cyclotides are a novel family of cyclic cystine knot containing peptides from plants that have been shown to possess anthelmintic activity against haemonchus contortus and trichostrongylus colubriformis, two important gastrointestinal nematodes of sheep. in the current study we demonstrated the in vitro effects ...200919059189
gastrointestinal parasites in dogs from the island of st. pierre off the south coast of newfoundland.the present work was performed to survey the gastrointestinal parasites of domestic dogs (canis lupus familiaris) and also to determine if any were infected with angiostrongylus vasorum (french heartworm), on the french island of st. pierre off the south coast of newfoundland. a total of 57 fecal samples were collected and examined for intestinal parasites. the overall prevalence of parasitism was 57.9% and the six species found were: uncinaria stenocephala/ancylostoma caninum (47.4%), toxocara ...200919303213
[prevalence of intestinal canine and feline parasites in saitama prefecture, japan].we studied the prevalence of intestinal parasites in animal companions in saitama prefecture, japan, where no detailed data is currently available. between may 1999 and december 2007, fecal samples were collected from 906 dogs and 1,079 cats in public animal shelters and examined by microscopy. overall, prevalence of intestinal parasites in dogs was 38.6% and cats 43.1%. trichuris vulpis was the most prevalent canine parasite species (22.3%), followed by toxocara canis (12.5%), ancylostoma canin ...200919522305
real-time pcr assays for monitoring benzimidazole resistance-associated mutations in ancylostoma caninum.frequent and broad application of anthelmintic drugs for treatment of intestinal parasite infection has led to drug resistance that often renders whole populations of livestock unresponsive to treatment. therefore, it is important to detect mutations associated with drug resistance before it becomes clinically manifest. to monitor developing drug resistance against benzimidazoles (bz), we developed real-time pcr assays and applied them to analyse the beta-tubulin isotype-1 gene of the hookworm a ...200919545525
field evaluation of the efficacy and safety of emodepside plus praziquantel tablets (profender tablets for dogs) against naturally acquired nematode and cestode infections in dogs.a controlled, blinded and randomised multicentre field study evaluated the efficacy and safety of a new anthelmintic tablet formulation containing emodepside plus praziquantel (profender tablets for dogs) in the treatment of gastrointestinal nematode and cestode infections in dogs in france, germany, portugal and slovakia. dogs positive for nematodes and/or cestodes (demonstrated by faecal egg counts and/or the presence of proglottids) were treated with emodepside plus praziquantel tablets (n = ...200919575222
proteomics analysis of the excretory/secretory component of the blood-feeding stage of the hookworm, ancylostoma caninum.hookworms are blood-feeding intestinal parasites of mammalian hosts and are one of the major human ailments affecting approximately 600 million people worldwide. these parasites form an intimate association with the host and are able to avoid vigorous immune responses in many ways including skewing of the response phenotype to promote parasite survival and longevity. the primary interface between the parasite and the host is the excretory/secretory component, a complex mixture of proteins, carbo ...200918753127
environmental monitoring and analysis of faecal contamination in an urban setting in the city of bari (apulia region, italy): health and hygiene implications.few studies have been conducted in italy to quantify the potential risk associated with dynamics and distribution of pathogens in urban settings. the aim of this study was to acquire data on the environmental faecal contamination in urban ecosystems, by assessing the presence of pathogens in public areas in the city of bari (apulia region, italy). to determine the degree of environmental contamination, samples of dog faeces and bird guano were collected from different areas in the city of bari ( ...201021139871
molecular cloning, biochemical characterization, and partial protective immunity of the heme-binding glutathione s-transferases from the human hookworm necator americanus.hookworm glutathione s-transferases (gsts) are critical for parasite blood feeding and survival and represent potential targets for vaccination. three cdnas, each encoding a full-length gst protein from the human hookworm necator americanus (and designated na-gst-1, na-gst-2, and na-gst-3, respectively) were isolated from cdna based on their sequence similarity to ac-gst-1, a gst from the dog hookworm ancylostoma caninum. the open reading frames of the three n. americanus gsts each contain 206 a ...201020145100
hookworms of dogs and cats as agents of cutaneous larva migrans.dogs and cats are hosts to hookworms that may cause zoonotic disease, most notably, cutaneous larva migrans. ancylostoma braziliense is most often implicated in dermatological lesions, and ancylostoma caninum has been associated with eosinophilic enteritis and suggested as a possible cause of diffuse unilateral subacute neuroretinitis in humans. other manifestations include eosinophilic pneumonitis, localized myositis, folliculitis, erythema multiforme, or ophthalmological manifestations. ancylo ...201020189454
intestinal helminths induce haematological changes in dogs from jabalpur, india.the effect of canine intestinal helminths on the haematological profile of 200 dogs, of both sexes and variable age, visiting university veterinary clinics for routine examination was investigated. the dogs were assigned to parasitized (n = 39) and non-parasitized (n = 161) groups of animals. coprological examination revealed a 19.5% prevalence of different species of the helminths. of these animals, 10.25% had mixed infections with ancylostoma caninum, toxascaris spp. and dipylidium caninum. th ...201021110909
intestinal parasites of dogs on the galapagos islands.dogs on the galapagos islands are a unique population created by isolation from the mainland and regulations prohibiting further importation. the effect of infectious agents of these domestic dogs on the indigenous fauna is largely unknown. the purpose of this study was to determine the prevalence of intestinal parasites in dogs on the galapagos islands. fecal samples were collected from 97 dogs presented during neutering campaigns on santa cruz (n=51), san cristobal (n=17), and isabela (n=29) i ...201020176441
epidemiology of intestinal helminth parasites in stray dogs from markets in south-eastern nigeria.a survey of gastrointestinal helminth parasites of stray dogs (canis familiaris) was conducted at obollo-afor and ekwulobia markets, in enugu and anambra states, south-eastern nigeria, respectively, to determine the patterns of infection among dogs in different parts of south-eastern nigeria. faecal samples collected, using long forceps, from every dog encountered in the markets between june 2007 and december 2008 were analysed by the kato-katz technique. out of 413 dogs examined in both markets ...201021144127
an epidemiological study of intestinal parasites of dogs from yucatan, mexico, and their risk to public health.abstract the prevalence of intestinal parasites in dogs and factors associated were studied in a rural community of yucatan (southern mexico), with special attention to those gastrointestinal parasites potentially transmitted to man. one hundred thirty dogs from 91 households were studied. fecal samples were processed by the centrifugation-flotation and the mcmaster techniques. to determine factors associated with zoonotic parasites in dogs, univariate analysis was performed, using sex, age, and ...201121395413
Pharmacokinetics of spinosad and milbemycin oxime administered in combination and separately per os to dogs.Holmstrom, S. D., Totten, M. L., Newhall, K. B., Qiao, M., Riggs, K. L. Pharmacokinetics of spinosad and milbemycin oxime administered in combination and separately per os to dogs. J. vet. Pharmacol. Therap. doi: 10.1111/j.1365-2885.2011.01333.x. Pharmacokinetic (PK) studies were conducted to determine the potential PK interactions when spinosad and milbemycin oxime (MBO) are administered simultaneously. Investigations used commercial MBO tablets (C-MBO; Interceptor(®) Flavor Tabs, active ingred ...201121895692
prevalence of selected zoonotic and vector-borne agents in dogs and cats in costa estimate the prevalence of enteric parasites and selected vector-borne agents of dogs and cats in san isidro de el general, costa rica, fecal and serum samples were collected from animals voluntarily undergoing sterilization. each fecal sample was examined for parasites by microscopic examination after fecal flotation and for giardia and cryptosporidium using an immunofluorescence assay (ifa). giardia and cryptosporidium ifa positive samples were genotyped after pcr amplification of specific ...201121846585
first report of ancylostoma ceylanicum in wild canids.the parasitic nematode ancylostoma ceylanicum is common in dogs, cats and humans throughout asia, inhabiting the small intestine and possibly leading to iron-deficient anaemia in those infected. it has previously been discovered in domestic dogs in australia and this is the first report of a. ceylanicum in wild canids. wild dogs (dingoes and dingo hybrids) killed in council control operations (n = 26) and wild dog scats (n = 89) were collected from the wet tropics region around cairns, far north ...201324533332
prevalence of gastrointestinal parasites in domestic dogs in tabasco, southeastern mexico.the overall goal of this study was to estimate the prevalence of gastrointestinal (gi) parasites in dogs in the city of villahermosa in tabasco, mexico. the study population consisted of 302 owned dogs that had limited access to public areas. a fecal sample was collected from each animal and examined for gi parasites by conventional macroscopic analysis and centrifugal flotation. fecal samples from 80 (26.5%) dogs contained gi parasites. of these, 58 (19.2%) were positive for helminths and 22 (7 ...201526648011
helminth infections in domestic dogs from russia.dogs are the hosts for a wide helminth spectrum including tapeworms, flatworms, and nematodes. these parasites affect the dog health and cause morbidity and mortality, especially in young and old animals. some species, as toxocara canis, ancylostoma caninum, dipylidium caninum, and echinococcus spp. are well-known zoonotic parasites worldwide, resulting in high public health risks. poor data about canine helminth species and prevalence are available in russia, mainly due to the absence of offici ...201627956777
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