Publications

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investigation of a mycobacterium bovis outbreak in cattle at a colorado dairy in 2010.to describe an epidemiological investigation of a bovine tuberculosis outbreak on a colorado dairy operation.201424649991
mycobacterium bovis ornithine carbamoyltransferase, mb1684, induces proinflammatory cytokine gene expression by activating nf-κb in macrophages.mycobacterium bovis is the etiological factor of bovine tuberculosis (btb), posing a significant problem to domestic cattle. the bacterium is also zoonotic, affecting human health worldwide. macrophage evasion of the bacterium involves mycobacterial molecules such as mb1684 (ornithine carbamoyltransferase). in this study, we confirmed a concentration-dependent decrease in proliferation of ana-1 macrophages when treated with rmb1684 when compared with mycobacterium bovis purified protein derivati ...201424568683
extent of mycobacterium bovis infection in dairy cattle herds subject to partial culling as determined by an interferon-gamma assay.the interferon-gamma (ifn-γ) assay is employed as a complementary diagnostic test for bovine tuberculosis (btb) in many countries. to simplify this assay, we established a 96-well plate format using the esat-6 and cfp-10 antigens and then employed it to determine the extent of mycobacterium (m.) bovis infection in dairy herds with a history of btb outbreaks in a country where only selective culling is practiced. the sensitivity and specificity of this ifn-γ assay were 85.9% and 100%, respectivel ...201424378586
evaluation of a commercial enzyme-linked immunosorbent assay for the diagnosis of bovine tuberculosis from milk samples from dairy cows.milk samples from dairy cows provide a ready source of material for measuring antibody responses to mycobacterium bovis antigens. in this study, we evaluated the idexx enzyme-linked immunosorbent assay (elisa) for the measurement of antibody responses to m. bovis antigens mpb70 and mpb83 in milk samples from new zealand cattle. test sensitivities for individual milk and serum samples were assessed in samples collected from 44 m. bovis-infected cows, and test specificities were assessed in milk s ...201324132605
extent of mycobacterium bovis transmission among animals of dairy and beef cattle and deer farms in south korea determined by variable-number tandem repeats typing.identifying sources of mycobacterium bovis transmission would be essential for establishing effective control programs of bovine tuberculosis (tb), a major zoonosis threatening human health worldwide. as an effort to determine the extent of m. bovis transmission among dairy and beef cattle and deer populations, a mycobacterial interspersed repetitive units (miru)-variable-number tandem repeats (vntr) typing method was employed for analysis of 131 m. bovis isolates from 59 holstein dairy cattle, ...201525676210
the evaluation of candidate biomarkers of cell-mediated immunity for the diagnosis of mycobacterium bovis infection in african buffaloes (syncerus caffer).we evaluated commercially available bovine enzyme linked immunosorbent assays (elisa) and a human ip-10 elisa to measure ip-10, mig, mcp-1, mcp-2, mcp-3 and il1-ra in buffalo plasma in order to identify sensitive markers of the immune response to mycobacterium bovis-specific peptides. additionally, we found that all coding mrna sequences of these cytokines showed very high homology with their homologues in domestic cattle (97-99%) as did the derived amino acid sequences (97-99%). this high seque ...201425464825
surveillance and movements of virginia opossum (didelphis virginiana) in the bovine tuberculosis region of michigan.wildlife reservoir hosts of bovine tuberculosis (btb) include eurasian badgers (meles meles) and brushtail possum (trichosurus vulpecula) in the uk and new zealand, respectively. similar species warrant further investigation in the northern lower peninsula of michigan, usa due to the continued presence of btb on cattle farms. most research in michigan, usa has focused on interactions between white-tailed deer (odocoileus virginianus) and cattle (bos taurus) for the transmission of the infectious ...201323531427
mycobacterium bovis dna detection in colostrum as a potential indicator of vaccination effectiveness against bovine tuberculosis.bovine tuberculosis (btb) remains a problem on many dairy farms in mexico, as well as a public health risk. we previously found a high frequency of mycobacterium bovis dna in colostrum from dairy cows using a nested pcr to detect mpb70. since there are no reliable in vivo tests to determine the effectiveness of booster mycobacterium bovis bcg vaccination against btb, in this work we monitored m. bovis dna in colostrum by using this nested pcr. in order to decrease the risk of adverse reactions i ...201323425597
wildlife reservoirs of bovine tuberculosis worldwide: hosts, pathology, surveillance, and control.bovine tuberculosis due to mycobacterium bovis is a zoonotic disease classically carried by cattle and spilling over into humans primarily by the ingestion of milk. however, in recent decades, there have been many endemic geographic localities where m. bovis has been detected infecting wildlife reservoirs, limiting the progress toward eradication of this disease from cattle. these include cervids in north america, badgers in great britain, feral pigs in europe, brushtailed possums in new zealand ...201323169912
surveillance for mycobacterium bovis transmission from domestic cattle to wild ruminants in a mexican wildlife-livestock interface area.to assess the prevalence of mycobacterium bovis infection in cattle and wild ruminants (wrs) in a wildlife-livestock interface area (wlia) of the mexican highland plateau.201223013189
population structure of mycobacterium bovis isolates from cattle in mexico.the molecular fingerprints of 878 isolates of mycobacterium bovis collected from cattle between 2009 and 2010 in different regions of mexico were used in this study. one hundred and ninety-four spoligotypes were observed in total with a high degree of heterogeneity. sixty-four percent of the isolates grouped into just nine spoligotypes, and 27% fell into only two spoligotypes: sb0673 and sb0669; 149 were orphan spoligotypes. the two predominant spoligotypes were found in almost all states in mex ...201222703980
detection of interferon-γ response to tuberculosis in blood collected at commencement of exsanguination at slaughter from cattle sensitized with mycobacterium bovis.to determine whether an interferon (ifn)-γ response sufficient to categorize cattle as positive for tuberculosis can be detected in blood collected at commencement of exsanguination at slaughter.201222620699
epidemiology, diagnostics, and management of tuberculosis in domestic cattle and deer in new zealand in the face of a wildlife reservoir.the control of tuberculosis (tb) in cattle and farmed deer in new zealand has been greatly influenced by the existence of a wildlife reservoir of mycobacterium bovis infection, principally the australian brushtail possum (trichosurus vulpecula). the reduction in possum numbers in areas with endemic m. bovis infection through vigorous vector control operations has been a major contributor to the marked reduction in the number of infected cattle and farmed deer herds in the past two decades. manag ...201524992203
development of a model to simulate infection dynamics of mycobacterium bovis in cattle herds in the united states.to develop a mathematical model to simulate infection dynamics of mycobacterium bovis in cattle herds in the united states and predict efficacy of the current national control strategy for tuberculosis in cattle.201323865885
gene polymorphisms in african buffalo associated with susceptibility to bovine tuberculosis infection.bovine tuberculosis (btb) is a chronic, highly infectious disease that affects humans, cattle and numerous species of wildlife. in developing countries such as south africa, the existence of extensive wildlife-human-livestock interfaces poses a significant risk of mycobacterium bovis transmission between these groups, and has far-reaching ecological, economic and public health impacts. the african buffalo (syncerus caffer), acts as a maintenance host for mycobacterium bovis, and maintains and tr ...201323691232
fine-mapping host genetic variation underlying outcomes to mycobacterium bovis infection in dairy cows.susceptibility to mycobacterium bovis infection in cattle is governed in part by host genetics. however, cattle diagnosed as infected with m. bovis display varying signs of pathology. the variation in host response to infection could represent a continuum since time of exposure or distinct outcomes due to differing pathogen handling. the relationships between host genetics and variation in host response and pathological sequelae following m. bovis infection were explored by genotyping 1966 holst ...201728646863
progenitor strain introduction of mycobacterium bovis at the wildlife-livestock interface can lead to clonal expansion of the disease in a single ecosystem.mycobacterium bovis infects multiple wildlife species and domesticated cattle across south africa, and negatively impacts on livestock trade and movement of wildlife for conservation purposes. m. bovis infection was first reported in the kruger national park (knp) in south africa during the 1990s, and has since spread to infect numerous animal host species throughout the park and across south africa. whole genome sequencing data of 17 m. bovis isolates were analyzed to investigate the genomic di ...201728412523
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