Publications

[preferential differentiation of hematopoietic stem cells transferred to mice previously infected by bcg].	following injection of bone marrow cells in lethally irradiated mice, previously infected with bcg regenerating hemopoietic cell populations differentiate along the leucocyte pathway to the detriment of erythroid lineage. such a phenomenon persisting even if anemia of infected mice is increased by bleeding just before irradiation and reconstitution supports the hypothesis of preferential differentiation of stem cells.	1977	406087
in vivo and in vitro responses of cats sensitized with viable mycobacterium bovis (bcg).	cats were injected subcutaneously with viable mycobacterium bovis (bcg), and immune responses were evaluated at various times after injection. the bcg injection produced fever, leukocytosis, neutrophilia, and lymphadenopathy of regional lymph nodes. intradermal tuberculin injection produced responses consistent with delayed type hypersensitivity reaction in the treated cats at postinoculation day 21. skin responses to tuberculin were not significant at postinoculation day 49. the cellular infilt ...	1979	393146
[bovine tuberculosis in a cat (author's transl)].	the clinical, radiographical and bacteriological findings in a siamese cat with bovine tuberculosis, are reported. in addition, the various forms of feline tuberculosis as well as the diagnostic procedures are reviewed.	1979	384599
bovine tuberculosis in the united states and puerto rico: a laboratory summary.	mycobacteria were isolated from 14.3% of the tissues submitted to the national veterinary services laboratories over a 5-year period (july 1, 1972, to june 30, 1977). the isolates were identified by drug susceptibility, and biochemical and serologic tests. mycobacterium bovis isolated from tissues of cattle originating in 32 states and puerto rico accounted for 78% of the acid-fast isolations. of the mycobacterium bovis isolates, 4% were from tissues in which no microscopic tuberculous granuloma ...	1979	378044
immunologic studies in holstein-friesian cattle: an immunocompetence profile.	an immunocompetence profile has been developed for holstein-friesian cattle. in vitro and in vivo immunoassays were used to determine (1) the percentage of peripheral blood lymphocyte (pbl) subpopulations bearing surface-membrane receptors for sheep erythrocytes, complement, or surface immunoglobulin; (2) the pbl blastogenic response to leukoagglutinin, concanavalin a, or pokeweed mitogen, (3) the serum immunoglobulin concentrations of igg, igm, and iga, (4) the humoral antibody response to keyh ...	1978	362996
macrophage fusion factor elicited from bgg-sensitized lymphocytes.	lymphocytes obtained from rabbit lymph nodes sensitized to bovine gamma globulin produce in vitro the lymphokine macrophage fusion factor (mff) which mediates the fusion of approximately 100% of normal alveolar and oil-induced peritoneal macrophages. giant cells (gc) of langhans and foreign body type form large syncytia containing as many as several hundred nuclei per cell. nuclei of gc appear more spherical and larger than those of the normal mononucleated macrophages, and they possess several ...	1978	362945
bovine tuberculosis in man--reinfection or endogenous exacerbation.	cattle tuberculosis was totally eradicated in sweden 20 years ago. twelve cases of bovine tuberculosis in man were reported in 1974 and 1975. all cases lived for many years in areas where cattle tuberculosis had previously been common. no recent source of infection could be demonstrated. these findings are in accordance with an exacerbation of a distant infection.	1978	356255
mycobacteria isolated from nasal secretions of tuberculin test reactor cattle.	nasal secretions of 103 holstein cows from a tuberculosis-infected herd in argentina were bacteriologically cultured for mycobacteria. mycobacterium bovis was isolated in 8.7% of the cultures. this method was useful for the detection of active tuberculosis with open lesions. other mycobacteria, most of which grew rapidly on culture media, were isolated in 32% of the cultures and were of little importance as sensitizing agents to mammalian tuberculin in experimental studies in guinea pigs.	1978	354437
enhancement of lymphocyte blastogenic and delayed hypersensitivity skin responses by indomethacin.	incubation of mycobacterium bovis-sensitized bovine peripheral blood lymphocytes with concanavalin a or m. bovis purified protein derivative and indomethacin caused a consistent, statistically significant increase in [3h] thymidine uptake as compared to cultures without indomethacin. the kinetics of the response showed that indomethacin must be added to lymphocyte cultures within hours after mitogen or antigen addition for enhancement of [3h]thymidine uptake to occur. lymphocyte blastogenic res ...	1978	352951
biochemical and functional characteristics of the plasma membrane of macrophages from bcg-infected mice.	a set of quantitative signs of activation, previously developed in studies of inflammatory peritoneal macrophages, has been applied to the study of immunologically stimulated peritoneal cells. mice that are infected systemically with bacillus calmette guérin (bcg) and then challenged locally with soluble mycobacterial antigens generate populations of cells that spread rapidly in culture, display an elevated pinocytic rate, ingest igmc-coated sheep erythrocytes, and have diminished levels of 5'-n ...	1978	351053
in vitro stimulation of bovine peripheral blood lymphocytes: suppression of phytomitogen and specific antigen lymphocyte responses by aflatoxin.	the effects of aflatoxin b1 on responses of the peripheral blood lymphocytes (pbl) of 2 normal animals to phytohemagglutinin, concanavalin-a, and pokeweed mitogen and of the pbl of 2 mycobacterium bovis-infected animals to phytohemagglutinin and purified protein derivative of m bovis (ppd) were studied. aflatoxin concentrations of greater than or equal to 10 microgram/ml significantly suppressed the lymphocyte response of normal animals to the phytomitogens. lymphocyte response of m bovis-infect ...	1977	339794
skin testing, fecal culture, and lymphocyte immunostimulation in cattle inoculated with mycobacterium paratuberculosis.	fourteen calves at 21 days of age were experimentally inoculated with 100 mg (wet weight) of mycobacterium paratuberculosis. three calves were inoculated orally, 4 intravenously, and 7 subcutaneously. lymphocyte immunostimulation, fecal culture, and intradermal tuberculin skin testing were done between 112 to 150 days following exposure. lymphocyte immunostimulation test results, conducted at 112 days after inoculation, showed all animals positive to mycobacterium avium purified protein derivati ...	1977	339793
[nonspecific reactions of cattle to tuberculin].		1977	337643
method for evaluation of mycobacterium bovis purified protein derivative tuberculin in experimentally infected cattle.	a method for the evaluation of mycobacterium bovis purified protein derivative (ppd) tuberculin in experimentally infected cattle is presented. the development of skin test responses in m bovis-infected cattle was determined for international standard ppd-s, m bovis ppd-2, and m bovis ppd-5 at 24, 48, and 72 hours. significantly larger reactions (dermal thickness) were observed at 48 and 72 hours than at 24 hours (p = 0.001). statistically significant differences were not detected in the respons ...	1977	329720
comparison of techniques for measuring the local and systemic responses to tuberculin in cattle.	thermography of tuberculin skin reactions in cattle sensitized with mycobacterium avium, mycobacterium bovis, or mycobacterium paratuberculosis was rapid and sensitive, but was not as specifically related to the homologous sensitization as was increased skin thickness at 48 and 72 hours. systemic temperature responses were more completely monitored by radiotelemetry of intraperitoneally located temperature transmitters than by rectal thermometry, but the temperatures indicated by the 2 methods w ...	1977	319714
purification of antibodies to bacterial antigens by an immunoadsorbent and a method to quantify their reaction with insoluble bacterial targets.	a combination of procedures was employed to develop a radioimmunoassay which quantified the binding of antibodies to antigens of either intact propionibacterium acnes or to antigens of insoluble extracts derived from the bacteria. reactive antibody populations were purified by use of bacterial immunoadsorbents which were prepared by coupling p. acnes to diethylaminoethyl cellulose. binding of antibodies was detected with [125i]staphylococcal protein a ([125i]spa) and optimal conditions for the a ...	1979	113462
comparison of the specificity of human and bovine tuberculin ppd for testing cattle. 2. south-eastern england.	a tuberculin testing trial was carried out in eight counties of south-eastern england to compare the specificity for bovine tuberculosis of weybridge human ppd with that of rotterdam bovine ppd. the matching of these two tuberculins for potency in naturally infected cattle had already been established, the bovine ppd being approximately one-and-a-half times more potent than the human ppd per unit of weight. in 1110 cattle in 25 herds with histories of long-standing freedom from tuberculosis and ...	1975	47751