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plasma concentrations of steroid hormones in sows infected experimentally with leptospira pomona or porcine enterovirus strain t1 in late gestation.plasma levels of progesterone, corticosteroids and oestrone were determined during the late stages of pregnancy in four sows experimentally infected with leptospira pomona and in a group of three sows in which fetuses were inoculated in utero with a strain of porcine enterovirus. only one of the seven infected sows farrowed at full term. all fetuses were dead and delivery was prolonged in litters infected with the virus. in the sows with leptospirosis almost all piglets were expelled dead or in ...1977557224
[study on avirulent leptospira pomona live vaccine in swine (author's transl)]. 1979262819
influence of seminal additives and packaging systems on fertility of frozen bovine spermatozoa.the following recommendations and conclusions are based upon results of fertility and laboratory studies, and general trends from field investigations. fertility results due to the addition of enzymes have been variable and contradictory. flushing of ampules with dry, gaseous nitrogen prior to filling has become a routine practice in processing semen to be frozen. for control of vibrio fetus and leptospira pomona, 2,000 micrograms of streptomycin and 1,000 u polymyxin b sulfate should be added p ...1978162535
[first demonstration of natural foci of leptospira pomona in the czech socialist republic (author's transl)]. 1979158439
serological studies on leptospirosis in cattle in east central alabama.serological surveys of leptospiral antibodies in cattle were carried out in macon and the surrounding counties of east central alabama. a total of 286 bovine serum samples were screened for the presence of antibodies against live antigens from twelve pathogenic leptospiral serotypes using a microscopic agglutination test. the most frequently encountered serotypes were leptospira hardjo (47%), leptospira wolffi (34%), leptospira canicola (12%), leptospira pomona (10%) and leptospira ballum (10%). ...1978567520
bovine mycotic abortion caused by acremonium kiliense grutz.acremonium kiliense was cultured from the placenta and abomasal contents of an aborted bovine foetus; attempts to isolate viruses and bacteria were unsuccessful although the serum of the dam contained antibodies to leptospira pomona. the fungus was nonpathogenic for mice but was able to survive in murine tissues for at least 13 weeks. the possibility of this case being a foetal infection as a result of insemination with contaminated semen is discussed.1979575677
[survival ability of leptospira pomona in kidney and muscle tissue of slaughtered pigs in freezing temperatures]. 1978646773
premature parturition in the california sea lion.twenty percent of the california sea lion pups born on san miguel island die due to premature parturition. specimens collected from premature-partus animals resulted in recovery of a virus, san miguel sea lion virus, indistinguishable from vesicular exanthema of swine virus, and leptospira pomona from some of the premature cows and pups. the age range of 10 females delivering healthy pups in june was 10-14 years. with one exception, the ages in 10 aborting females was 6-8 years. the p,p'-dde le ...1976815567
naturally-occurring leptospirosis in northern fur seals (callorhinus ursinus).a 4-year study of northern fur seal (callorhinus ursinus) leptospirosis in the bering sea has shown that in newborn pups leptospira pomona is associated with a multiple hemorrhage syndrome. adults may develop an interstitial nephritis and shed organisms in the urine. the hed prevalence, based on microscopic slide agglutination tests, ranged between 7.0% and 15.4% for adult females and 3-4 year old bachelor bulls, whereas nursing pups averaging 4 months of age had a prevalence of 2%. these result ...1977864847
serologic survey of leptospiral antibodies in horses in california.a serologic survey was made of the prevalence of common leptospiral infections in horses in california. a total of 465 serums were tested, using the microscopic agglutination method, against 5 leptospiral serotypes: leptospira pomona, leptospira icterohaemorrhagiae, leptospira canicola, leptospira grippotyphosa, and leptospira hardjo. of the serums tested, 127 (27.30%) were positive against 1 or more of the leptospires, with percentage distribution among the reactors as follows: l pomona, 12.47% ...1977921041
isolation and chemical characterization of outer envelope of leptospira pomona.cells of leptospira interrogans serotype pomona harvested from a chemically defined medium were resuspended in 0.01 m phosphate buffer of ph 7.3. electron microscopy showed that 90 min of exposure effectively ruptured the outer envelope, freeing it from the cells as small flakes. both zonal centrifugation in sucrose gradients and centrifugation in isopycnic kbr and cscl gradients could be used to separate the outer envelope from the axial filaments and protoplasmic cylinders. the latter metho ...19751148944
assay for measuring relative potency of leptospiral bacterins containing serovar pomona.an enzyme-linked immunosorbent assay (elisa) was developed for the quantitation of leptospiral antigen in bacterins containing leptospira interrogans serovar pomona type kennewicki. a monoclonal antibody (mab), 2d7, which is directed against a surface antigen on whole cells of l. interrogans serovar pomona type kennewicki, was used in the assay. the capture of antigen in bacterins by a polyclonal antiserum was followed by the addition of the 2d7 ascites fluid, an anti-mouse conjugate and substra ...19921305402
[attempts at obtaining a pentavalent vaccine against leptospirosis].obtained was a five-valent vaccine (leptospira pomona, l. canicola, l. grippotyphosa, l. mitis, and l. icterohaemorrhagiae). it was found that storage at 4degreesc does not impair the immunogenicity of the vaccine in the course of one year. three groups of rabbits were used to test its immunogenicity--group i, injected once, subcutaneously, with 1 cu. cm of the vaccine; group ii, injected subcutaneously, twice, at an interval of 7 days, with 1 cu. cm of the vaccine each time; and group iii, inje ...19751216680
[a clinicopathological analysis of 12 cases of cerebrovascular leptospirosis].12 pathologically verified cases of cerebrovascular leptospirosis were analysed of its clinical characteristics and types. formation and development of cerebral panarteritis and infarctions were also discussed. it occurred in rural areas among children and adolescents after infection by leptospira pomona, especially following latent infection. multiple occlusive vascular disorder presenting as a late manifestation of pomona infection occurred in 9 cases, intracranial hemorrhage in 2, and intracr ...19902253511
the prevalence of leptospirosis and its association with multifocal interstitial nephritis in swine at slaughter.an abattoir survey was undertaken to determine the prevalence of leptospirosis and its association with lesions of multifocal interstitial nephritis (so-called "white spotted kidneys") in swine at slaughter. both cross-sectional and case-control study designs were used. of 197 kidneys from hogs randomly selected at slaughter, 11 (5.6%) had generalized grey-white foci typical of multifocal interstitial nephritis (mfin). antibody titers greater than or equal to 1:80 against leptospira pomona were ...19892766150
[survival rate of leptospira pomona in the soil at a natural leptospirosis focus].at the area of a natural focus of leptospirosis (caused by l. pomona) in the mozdok region of the north occetic assr leptospires were detected by the method of dark field microscopy in 22% of intact soil samples. the presence of pathogenic leptospires in this soil was not confirmed by the method of the biological assay on syrian golden hamsters. in controlled tests lasting 1-277 days, in 30.4% of cases l. pomona retained their viability, pathogenic and antigenic properties for as long as 74 days ...19892728704
leptospirosis as a cause of "white spot" kidneys in south african pig abattoirs.the incidence of isolation of leptospira sp. from the kidneys of slaughter pigs with "white-spot" macroscopic lesions was determined. histology and general bacteriology were performed. leptospira pomona was isolated from 19/21 kidneys showing macroscopic lymphocytic lesions.19873587928
[the noncorrespondence of the geographic ranges of the host and the causative agent].for the first time the experimental and field studies of leptospira infections, carried out over the period of 6 years, have revealed that the habitat of striped field mice (apodemus agrarius pallas 1778) serving as a host for leptospira pomona, serovar mozdok, is much wider than the habitat of the infective agent proper. the presence of an animal species highly sensitive to a definite leptospiral serovar and serving as its reservoir at a given locality cannot be regarded as a proof of the prese ...19882977463
cell-mediated immune response of goats to leptospirosis.cell-mediated immunity to leptospira pomona was measured in goats by the leukocyte-migration inhibition test (lmit) and microassay for stimulation of protein synthesis (sps) with 3h-leucine. l. pomona soluble antigen was used in both tests. the migration indices in the group of goats infected with l. pomona were significantly lower (less than .001) as compared to control. the migration zones of the unstimulated peripheral blood leukocytes in the infected group were significantly smaller (less th ...19883227798
[morphology of a natural focus of pomona leptospirosis in a steppe area].the natural focus of leptospira pomona infection has been found to include areas of the forest-meadow flood plain where the circulation of leptospires is constantly maintained among small mammals (the nucleus of the focus). a high level of leptospira carriership (17.7%) among the animals has been registered in the central part of the flood plain and near the terraces, these areas having the most favorable conditions for the development of epizootic leptospirosis.19863765972
[cloning and the expression of the hemolysin gene of leptospira pomona pomona in escherichia coli].the library of leptospira pomona genes was obtained on phage vector al 47.1. from this library a recombinant phage carrying the hemolysin gene was selected. the dna fragment (7.7 kb) of this phage containing the hemolysin gene was subcloned on plasmid puc19. e. coli clones with hybrid plasmid pdr7 were shown to be hemolytic, but the secretion of hemolysin by e. coli into the culture medium was not observed.19853901626
antibody response of cattle to leptospira pomona: response as measured by hemagglutination, microscopic agglutination, and hamster protection tests. 19714108773
vaccination against leptospirosis: protection of hamsters and swine against renal leptospirosis by killed but intact gamma-irradiated or dihydrostreptomycin-exposed leptospira pomona. 19674169487
failure to eliminate leptospira pomona from pigs by treatment with long acting oxytetracyline. 19854084154
endometrial changes in nonpregnant ewes infected with leptospira pomona. 19704191788
correlation of bedrock type with the geography of leptospirosis.leptospirosis occurs enzootically over most of southern ontario. leptospira pomona is the serotype most commonly found in outbreaks. antibodies to l. pomona occur frequently in the sera of deer in wilderness areas. the geographic location of leptospirosis presents a pattern which closely parallels the distribution of paleozoic bedrock. by contrast, l. pomona infection is absent from areas underlain by precambrian bedrock. comparisons of water chemistry, soil type, habitat, and host and pathogen ...19704246001
letter: the isolation of leptospira pomona from a sick foal. 19744414429
renal failure and transient paraproteinemia due to leptospira pomona. case reports and literature review. 19734573664
a premature birth associated with leptospira pomona infection in a mare. 19724651124
safety of viable, avirulent leptospira pomona vaccine in pregnant cows. 19734685540
leptospira pomona and reproductive failure in california sea lions. 19744443311
leptospira pomona infection in wombats. 19734694593
nutritional requirements of leptospirae. iv. vitamin requirements of leptospira pomona and its growth in a minimal medium. 19684870972
growth requirements of pathogenic leptospira.nutritional requirements for growth at 30 c of leptospira pomona and l. canicola have been determined. both pathogenic serotypes initially required bovine serum albumin (bsa) for growth in a medium (sm-4) which permitted growth of the water isolate b-16. requirement for bsa was eliminated by (i) removing much of the apparent toxicity of free fatty acids in tween 80 on an anion exchange column, (ii) decreasing extended lag periods observed from small inocula by incorporation of pyruvate into the ...19734716547
[liver changes in leptospira infections (leptospira icterohaemorrhagia and leptospira pomona)]. 19734739718
nutritional requirements of leptospirae. 3. minimal nitrogen requirements of a strain of leptospira pomona. 19684870971
antibody response of cattle to leptospira pomona: a hemagglutination test to measure igg and igm antibodies. 19715131418
[experiences in porcine leptospirosis campaign with special reference to leptospira pomona infection]. 19715146334
isolation of leptospira pomona from a naturally infected california sea lion, sonoma county, california. 19715156488
avirulent leptospira pomona vaccine: stability of the noninfectious character in vitro and in vivo. 19685257460
[epidemiological studies on human infection with leptospira tarassovi and leptospira pomona]. 19695393095
[studies of the presence of leptospira pomona titers in sheep in the schwerin region]. 19705498052
experimental equine leptospirosis (leptospira pomona). 19645217493
specificity of lipase from several seeds and leptospira pomona. 19705528249
duration of immunity in cattle in response to a viable, avirulent leptospira pomona vaccine. 19715556828
[leptospira pomona infection in young cattle]. 19675627645
vaccination of hamsters, swine, and cattle with viable, avirulent leptospira pomona. 19685690782
biological effects of leptospiral lipids.lipids were extracted from virulent leptospira pomona and were purified. these lipids fixed complement in the presence of antiserum to l. pomona but did not stimulate the production of homologous agglutinins in rabbits, mice, or hamsters. when subsequently challenged, all of the mice and hamsters were fully susceptible to l. pomona. the lipid material was neither dermonecrotic nor lethal for mice or hamsters, but 382 mug of lipid from virulent or avirulent leptospires inhibited the growth of nor ...19685640382
the susceptibility of mice to leptospira pomona. 19685729732
rupture of leptospira pomona cells by explosive decompression. 19695812016
field and laboratory studies of skunks, raccoons and groundhogs as reservoirs of leptospira pomona. 19655828180
effect of cortisone on leptospira pomona infection in guinea pig. 19655848746
leptospira pomona in tissue culture: preliminary study. 19665913031
mechanisms of tissue cell penetration by leptospira pomona: phagocytosis of leptospires in vitro. 19665959400
leptospiral selection, growth, and virulence in synthetic medium.stalheim, o. h. v. (national animal disease laboratory, ames, iowa). leptospiral selection, growth, and virulence in synthetic medium. j. bacteriol. 92:946-951. 1966.-the need for protein in leptospiral cultural medium may be circumvented by the use of strains which tolerate the lytic activity of polyoxyethylene sorbitan monooleate (tween 80), a relatively nonlytic source of essential fatty acids. in an otherwise adequate medium, the primary function of a serum protein (bovine albumin fraction v ...19665926762
response of erythrocytes to leptospira pomona hemolysins during infection. 19665971616
the renal carrier state of experimenal leptospira pomona infections in skunks (mephitis mephitis). 19676017273
[leptospira pomona infection in swine]. 19666007211
streptomycin treatment of bovine carriers of leptospira pomona. 19676033736
a toxic factor in leptospira pomona. 19676082707
leptospiral abortion of beef cattle caused by leptospira pomona and leptospira hardjo. 19676069990
experimental infection with the virulent, central-european, murine leptospira pomona strain in the pig.the virulent, murine leptospira pomona strain isolated from apodemus agrarius was used in an experimental infection of six pigs aged 4--5 months. the clinical course of the infection was inapparent, both the blood picture and the uptake of food were normal. all infected pigs produced antibodies against l. pomona at titres from 1:3 200 to 1:50 000. the reisolation of leptospires from the blood of the infected pigs was successful in one case only, and that on day two p.i. throughout the course of ...19836629206
renal lesions in leptospirosis.renal function studies and kidney biopsies were performed in four patients presenting with renal insufficiency and acute leptospira pomona infection. the renal lesion in all patients revealed acute interstitial nephritis. there was no evidence of immunologically mediated disease in three patients who were biopsied seven, eight and eight days respectively following the onset of symptoms. the fourth, in whom there was no evidence of prior renal disease, and whose biopsy was performed 16 days after ...19826958239
evaluation of usefulness of 2-mercapto-ethanol treatment in serodiagnosis of swine leptospirosis.serum samples of piglets infected artificially or naturally, respectively, with leptospira pomona were treated with 2-mercapto-ethanol (me) and tested in the microscopic agglutination test in comparison with untreated sera. serum-treatment with me showed two beneficial effects, one being the total elimination of heterotypic reactions, the other the reduction or elimination, respectively, of early antibodies, presumably belonging to the igm class. accordingly, two practical implications can be de ...19836688116
a minireview of the pathogenesis of acute leptospirosis.hemorrhagic diathesis is one of the most striking manifestations in acute leptospirosis. hemorrhages are seen in infections due to leptospira icterohaemorrhagiae as well as in those caused by leptospira pomona. thrombocytopenia is a constant feature and its finding can be useful for the diagnosis. attempts to demonstrate the presence of a toxin in leptospires were unsuccessful. a few years ago, a syndrome of disseminated intravascular coagulation was associated with the physiopathogenesis of exp ...19817044515
human leptospirosis in detroit and the role of rats as chronic carriers.human leptospirosis was diagnosed in three patients from detroit general hospital. epidemiological studies of these cases revealed heavy rat infestations in the residences of two of the patients. leptospires serotype icterohaemorrhagiae were isolated from the rats and one of the patients. cultural isolation was attempted from numerous blood and urine samples from each patient. media containing different selective contaminant inhibitor substances was also utilized. only two samples were culturall ...19807461920
ultrastructure of renal lesions in pigs with acute leptospirosis caused by leptospira pomona.twelve 4-day old, pathogen-free pigs were inoculated intraperitoneally with virulent l. pomona. two pigs each were killed 1, 2, 3, 5, 7, and 14 days after inoculation and their kidneys examined by light and electron microscopy. three to 5 days after inoculation there was hyperemia, edema and swelling of tubular epithelium; leptospires were detected intravascularly, in interstitium and embedded within basement membranes. at day 7, leptospires were at basal surfaces of proximal tubules and in phag ...19807368526
[zoonoses in vojvodina. iii. results of a seroepidemiologic study of leptospirosis in vojvodina].2697 persons professionally exposed to leptospira working in contaminated waters and grounds or due to contact with infected animals or their products were seroepidemiologically examined. it was established that the presence of leptospirosis in certain categories of examined persons is three to more than ten times higher in relation with it's presence in the control groups. the most frequent serotype was leptospira pomona. none of the seropositive persons gave data about having leptospirous infe ...19947791675
studies on inactivation of pathogenic microorganisms in culture media and in bovine semen by photosensitive agents.the application of three photosensitive agents for disinfection of bovine semen was investigated. bovine microbial pathogens suspended in tissue culture medium and/or pbs and also added to bovine semen were exposed to the photosensitive agents followed by irradiation. hematoporphyrin, hematoporphyrin derivative and thiopyronine were effective against bovine herpes virus-1, bovine viral diarrhoea virus, mycoplasma bovigenitalium, mycoplasma canadense, and ureaplasma diversum in culture media. in ...19948017031
prevalence of leptospira antibodies in white-tailed deer, cades cove, great smoky mountains national park, tennessee, usa.we conducted a study of the population dynamics, movement, and diseases of white-tailed deer (odocoileus virginianus) in cades cove, great smoky mountains national park, tennessee (usa) from 1980 to 1984. during the study 590 blood samples were collected from 518 deer, with some deer recaptured one or two times. the estimated percent of the herd sampled each year ranged from 8% to 28%. we also collected serum samples from 56 cattle pastured in cades cove. deer and cattle sera were tested using t ...19938258854
evaluation of the leptospira pomona elisa and its correlation with the hamster potency assay. 19968785980
leptospirosis in california sea lions (zalophus californianus) stranded along the central california coast, 1981-1994.prevalence of leptospirosis was determined in california sea lions (zalophus californianus) stranded live along the central california (usa) coast between january 1981 and december 1994. clinical signs of renal disease were seen in 764 (33%) of 2338 animals examined; 545 (71%) of these 764 animals died, with similar gross lesions of nephritis. in silver impregnation stains of sections of formalin-fixed kidney, numerous loosely coiled spiral organisms were observed. leptospira pomona kenniwicki w ...19969359054
naturally acquired leptospirosis in 36 dogs: serological and clinicopathological features.case records of 36 dogs with confirmed leptospirosis diagnosed at the new york state college of veterinary medicine from 1980 to 1995 were reviewed retrospectively, and clinical, serological and pathological findings were recorded to characterise the epidemiology of this disease in upstate new york. titres were directed predominantly against serovars grippotyphosa and/or pomona in 31 of 34 dogs. convalescent titres were measured for 53 per cent of dogs. the most common clinical presentation was ...19989631358
treatment and outcome of dogs with leptospirosis: 36 cases (1990-1998).to characterize serologic and clinical features and outcome of dogs with leptospirosis that were treated conservatively (i.e., medical management alone) or with hemodialysis.200010668536
preliminary study on differentiation of leptospira grippotyphosa and leptospira sejroe from other common pathogenic leptospiral serovars in canine urine by polymerase chain reaction assay.a multiplex polymerase chain reaction (pcr) method using primer sets of g1/g2 and b64-i/b64-ii was validated to detect pathogenic leptospira serovars from canine urine samples. the pcr method was found to be specific and sensitive with a detection limit of 100 cells of leptospira icterohaemorrhagiae per milliliter of urine. the primer set previously designated and erroneously transcribed b64-i/b64-ii amplified a dna fragment of 352 base pairs from leptospira grippotyphosa and leptospira sejroe b ...200211939341
[leptospirosis as a differential diagnosis of acute renal failure].leptospirosis is a worldwide infectious disease affecting both animals and humans. leptospira pomona is well known as a pathogen of a mild form of leptospirosis (maladie des jeune porchers).200212386795
infection with leptospira pomona; report of two cases. 195213005123
leptospirosis due to leptospira pomona; report of first case in iowa and a review of the literature. 195313044996
acute leptospira pomona arthritis and myocarditis. 195313065996
an illinois practitioner's survey of leptospira pomona in cattle. 195313108811
leptospirosis in swine caused by leptospira pomona. 195413143222
[epidemic of leptospirosis in a bosnian village caused by leptospira pomona]. 195313153748
status of leptospirosis as caused by leptospira pomona infection. 195413162913
isolation of leptospira pomona from a bovine eye. 195413201505
leptospira pomona infection in man and animals in iowa. 195413174875
[the first isolation of leptospira pomona strains in man in croatia]. 195413179726
histopathological findings in cows naturally infected with leptospira pomona. 195513228866
an immunogenic agent for the protection of cattle against leptospira pomona. 195513238739
protection afforded guinea pigs by porcine gamma globulin against leptospira pomona infection. 195513261570
experimental leptospirosis. ii. the role of calves in the transmission of leptospira pomona among cattle, swine, sheep, and goats. 195613306661
the effect of revaccination of horses and cattle with leptospira pomona bacterin. 195613306658
experimental leptospirosis. i. the course of leptospira pomona infection in pregnant heifers. 195613295122
serological cross-agglutination reactions between leptospira pomona and leptospira icterohaemorrhagiae, ab. 195613340129
[simultaneous infection with leptospira pomona and leptospira hyos]. 195613351595
an experience with a leptospira pomona bacterin in dairy cattle. 195613357395
the susceptibility of several different laboratory animals to infection with leptospira pomona. 195613357773
the possible role of ticks as vectors of leptospirae. i. transmission of leptospira pomona by the argasid tick, ornithodoros turicata, and the persistance of this organism in its tissues. 195613375683
virulence of leptospira pomona in hamsters and cattle. 195713394814
studies on bovine leptospirosis. iii. isolation of leptospira pomona from surface waters. 195713394820
pretibial fever due to leptospira pomona; report of two cases in siblings. 195713417040
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