Publications

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mansonella streptocerca in the central african republic. 19883232187
[action of hetrazan on dipetalonema streptocerca]. 195015413862
reduction in the prevalence and intensity of infection in onchocerca volvulus microfilariae according to ethnicity and community after 8 years of ivermectin treatment on the island of bioko, equatorial guinea.bioko is the only island known in the world with endemic onchocerciasis. the island's rural communities consist of villages and cocoa plantations inhabited by bubi and fang ethnic groups. the aim of this study was to evaluate the impact of 8 years of vertical ivermectin distribution on the prevalence and intensity of onchocerca volvulus infection in the rural population by means of pre- (1989) and post-long term treatment (1998) epidemiological surveys. in both surveys, the entire population of ...200616827709
plasmodium vivax and mansonella ozzardi co-infection in north-western argentina.a case of co-infection with plasmodium vivax and mansonella ozzardi was detected in a blood sample from a person who had shown symptoms of malaria and lived in a city that was close to the argentina/bolivia border. the case was detected during a random revision of thick and thin smears from patients diagnosed with malaria from various towns and cities located in north-western argentina between 1983 and 2001. trophozoites of p. vivax were observed in the thin blood smear along with m. ozzardi mic ...201323866313
[note on the presence of microfilaria (dipetalonema) streptocerca (macfie and corson, 1922) in upper volta, french west africa]. 195114918693
single molecule sequencing and genome assembly of a clinical specimen of loa loa, the causative agent of loiasis.more than 20% of the world's population is at risk for infection by filarial nematodes and >180 million people worldwide are already infected. along with infection comes significant morbidity that has a socioeconomic impact. the eight filarial nematodes that infect humans are wuchereria bancrofti, brugia malayi, brugia timori, onchocerca volvulus, loa loa, mansonella perstans, mansonella streptocerca, and mansonella ozzardi, of which three have published draft genome sequences. since all have hu ...201425217238
towards novel antifilarial drugs: challenges and recent developments.filariasis is caused by thread-like nematode worms, classified according to their presence in the vertebrate host. the cutaneous group includes onchocerca volvulus, loa loa and mansonella streptocerca; the lymphatic group includes wuchereria bancrofti, brugia malayi and brugia timori and the body cavity group includes mansonella perstans and mansonella ozzardi. lymphatic filariasis, a mosquito-borne disease, is one of the most prevalent diseases in tropical and subtropical countries and is accom ...201021426193
immunohistochemical detection of dirofilaria immitis using a rabbit polyclonal anti-serum against adult somatic antigens and excretory-secretory products.an immunohistochemical study on tissue sections of kidney, lung, liver and spleen from six dogs naturally infected by dirofilaria immitis was carried out, using a rabbit polyclonal anti-serum against somatic antigen (sa) of adult worms, excretory-secretory products (es) of adult worms and fraction c3 of complement (dog c3). positive immunoreactions were observed on circulating microfilariae when anti-sa and anti-es were used, but no differences were noted between the two anti-sera. no antigen de ...19979802110
detection of the filarial parasite mansonella streptocerca in skin biopsies by a nested polymerase chain reaction-based assay.to differentiate the skin-dwelling filariae mansonella streptocerca and onchocerca volvulus, a nested polymerase chain reaction (pcr) assay was developed from small amounts of parasite material present in skin biopsies. one nonspecific and one specific pair of primers were used to amplify the 5s rdna spacer region of m. streptocerca. biopsies with different microfilaria densities obtained from 104 ugandans living in an area endemic for m. streptocerca were tested using both the nested pcr assay ...19989660471
treatment of human mansonella streptocerca infection with ivermectin.we studied the short-term effects of a single dose of 150 micrograms/kg body weight ivermectin on mansonella streptocerca in an area endemic for streptocerciasis, but not for onchocerciasis, in western uganda. six and 12 days after treatment no microfilaria (mf) were found in the skin of 53 out of 96 mf carriers living in 3 villages, and the geometric means of the mf densities of remaining mf carriers were only 33-40% of pretreatment levels. this reduction of mf density was highly significant (p ...19979472305
studies on filariasis in bauchi state, nigeria. v. the distribution and prevalence of mansonellosis with special reference to clinical signs.a survey on mansonellosis was carried out in bauchi state of nigeria between january 1990 and march 1992. of the 5,640 inhabitants examined, 24 (0.4%) were positive for mansonella streptocerca microfilariae. microfilaria rate and mf density increased gradually with host age. while infection and sex are independent, mansonellosis was significantly lower in subjects within the first three decades of life than in those above 31 years (p < 0.05). clinical signs observed include pruritus, rash, ingui ...19947951395
prevalence, geographical distribution and clinical manifestations of onchocerciasis on the island of bioko (equatorial guinea).a survey for the prevalence, geographical distribution and clinical manifestations of onchocerciasis was conducted on the island of bioko (formerly fernando póo), equatorial guinea, between 1987-89. the whole population (1799 inhabitants) of thirteen villages distributed around the island was surveyed. identification data, physical examination and snellen "e" test for visual acuity were performed. skin snips were taken from both iliac crests and right scapula and calf. differential diagnosis bet ...19957631122
the tail of the mansonella streptocerca microfilaria.morphological studies of stained mansonella streptocerca microfilariae from the skin of man and chimpanzees in west africa revealed that the tail is bifid rather than blunt. this feature may be useful in characterization of related species.19846507737
dipetalonema streptocerca (macfie and corson, 1922): description of the adult female.morphologic features of the adult female dipetalonema streptocerca and microfilariae are described and illustrated from serial paraffin sections of biopsied skin from eight africans. characteristic features include a maximum diameter of 85 microns, a thin, smooth cuticle, and uteri that fill the body cavity. d. streptocerca is briefly compared to onchocerca volvulus.19751168032
elevated antifilarial igg4 antibody levels in microfilaremic and microfilaridermic gabonese adults and children.immunologic analyses of sera from 47 selected individuals living in a mixed filariasis transmission zone in gabon were carried out. onchocerca volvulus, loa loa, mansonella streptocerca, and m. perstans are transmitted in this region. based on parasitologic findings and age, the 47 individuals were stratified into four groups: microfilaria negative (mf-) children (3-15 years old), mf- adults (> 15 years old), microfilaria positive (mf+) children and mf+ adults. for descriptive purposes, the term ...19938352386
streptocerciasis: observation of adult male dipetalonema streptocerca in man.in 75 biopsy specimens of skin from 34 patients with streptocerciasis who had been treated with diethylcarbamazine, we found 39 female and six male adult dipetalonema streptocerca in the dermal collagen. this is the first report of adult male d. streptocerca in man, and identifying features are described.1977563682
occurrence and diagnosis of mansonella streptocerca in uganda.during filaria surveys mansonella streptocerca was found for the first time in uganda, in 12 widely scattered villages in the bundibugyo district between the ruwenzori mountains and the ituri forest, an area not endemic for onchocerca volvulus. the crude prevalence in 806 examined adult persons ranged from 5 to 89% with an average of 61%. in 148 children the prevalence was 36%. the geometric mean of microfilaria (mf) densities in adult mf carriers was 1.7 mf/mg skin and the community microfilari ...19979083584
loa loa and mansonella perstans filariasis in the chaillu mountains, congo: parasitological prevalence.1934 bantus and 379 pygmies were investigated for loa loa and mansonella perstans filariasis in 7 villages in the chaillu forest of the congo. bantus were more frequently infected with l. loa than pygmies (18.9% of microfilariae carriers compared with 10.6%). in individuals over 30 years of age, males were more frequently infected than females. microfilarial densities increased until the age of 20 years and then remained stable. parasite load was not significantly different in the two ethnic gro ...19892617607
recovery of intact male and female dipetalonema streptocerca from man.when attempts at teasing adult dipetalonema streptocerca free from biopsy specimens of human skin proved futile a digestion procedure was initiated. punch biopsy specimens fixed in michel's solution (ammonium sulfate) were incubated at 25 degrees c for 3 days in a 1.0% solution of collagenase in tris-hcl buffer. intact worms were carefully teased out of the digested collagen and camera lucida drawings and measurements were then possible. this marks the first description of intact d. streptocerca ...1979571213
an internal control for the detection of onchocerca volvulus dna by pcr-elisa and rapid detection of specific pcr products by dna detection test strips.we developed a polymerase chain reaction-enzyme-linked immunosorbent assay (pcr-elisa) for the detection of onchocerca volvulus dna. to standardize the pcr and to avoid false-negative results, an internal control dna was co-amplified by the same set of primers. we differentiated the wild-type pcr product of the o-150 dna sequence from the internal control by specific dna probes. detection of biotinylated pcr products by dna probes was performed by elisa to quantify the pcr product or by dna dete ...200212031075
long-term suppression of mansonella streptocerca microfilariae after treatment with ivermectin.the long-term effect of a single oral dose of 150 microg/kg of body weight of ivermectin on mansonella streptocerca microfilariae was studied in western uganda. before treatment, the geometric mean microfilaria density (mf) in 93 infected persons was 2.4 mf/mg of skin (range, 0.1-42.6). one year after treatment, 43 persons (46%) were microfilaria-negative, and the geometric mean in the remaining persons dropped significantly, to 0.7 mf/mg (range, 0.1-6.9). thus, ivermectin is highly effective ag ...199910479183
mansonella streptocerca: another filarial worm in the skin in western uganda. 199817492030
streptocerciasis: degeneration of adult dipetalonema streptocerca in man following diethylcarbamazine therapy.thirty-three patients in zaire with streptocerciasis were treated daily with diethylcarbamazine (dec) for 21 days. histopathologic studies of biopsy specimens with papules of skin established that during dec treatment adult male and female dipetalonema streptocerca die and degenerate. dec may thus produce radical cures of streptocerciasis.1978569443
[epidemiological status of onchocerciasis in the congo].analysis of 25 surveys carried out in the congo between 1978 and 1987 (covering nine of the ten administrative regions), during which 6,215 subjects were examined, showed that onchocerciasis is endemic in the southern part of the country. two main foci meeting at the southern exit of brazzaville (pool region) were identified. one focus in the djoué basin. the other is the zone along the congo river stretching from below brazzaville south west to the zaire border. two secondary foci were noted, o ...19902241306
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