| effect of dimedrol, diazoline, diprazin and ethysine on formation of the primary immune response. | tests were conducted on mice of the cba line, immunized through a single intraperitoneal administration of 0.5 ml of a 5% sheep erythrocytes suspension. antihistaminic agents were introduced by the intraperitoneal route in a dose of 5 mg/kg, first at one time and then repeatedly at various intervals with respect to the initial immunization benadryl and diazoline, when administered in a single dose to mice 24 hours after immunization activated the primary immune response to sheep erythrocytes, wh ... | 1976 | 15855 |
| effect of cholinergic substances on brain potentials induced by tooth pulp stimulation. | introduction of the m-cholinomimetic -- arecoline into the ventricle of the rabbit's brain decreases and of the m-cholinolytic -- atropine -- increases the amplitude of primary responses in the sensomotor region of the cortex, arising out of stimulating the dental pulp. the n-cholinomimetic -- lobeline potentiates the evoked response of the brain cortex, whereas the n-cholinolytic -- beta-ethylene-splasmolytin -- depresses it. it is assumed that the region of the drugs action application are tha ... | 1977 | 15860 |
| phencarol--an antihistaminic preparation from the quinuclidylcarbinol group. | a high antihistaminic activity of quinuclidyl-3-diphenylcarbinol (phencarol) has been ascertained. in pharmacological experiments phencarol is superior to dimedrol (diphenhydramine), both as concerns its antihistaminic activity and the duration of its action. unlike dimedrol and diprazine (promethazine) it has no inhibitory effect on the central nervous system. with its clinical use phencarol is effective in treating urticaria, quincke's edema and allergic skin reactions. the drug is well tolera ... | 1977 | 15861 |
| study of the effect of corticosterone on erythrocyte membranes by the spin label method. | influence of corticosterone on the hare's erythrocyte ghosts is studied by the spin-label method. there exists a correlation between the maximal variation region in the rotational diffusion "frequency" of the spin-labels, covalently linked with the membrane protein, and the hormones concentration range within which the effect of corticosterone on the functions of the erythrocyte membranes manifests itself to the greatest degree (permeability to ions, hemolytic effects, etc). | 1977 | 15862 |
| derivatives of dithiocarbamic acid as inhibitors of catecholamine biosynthesis (review of the literature). | | 1977 | 15863 |
| the activation of intravascular coagulation by bromocarbamide. | in the rabbit the application of a non-lethal, sleep-inducing dose of bromisovalerianyl carbamide (0.5 g/kg body weight) causes an activation of the coagulation system. this activation is manifested by shortened thrombin and partial thromboplastin times and a decrease of fibrinogen concentration and factor v activity. in contrast, pentobarbital sodium at a dose (62.5 mg/kg) which causes the same changes in arterial partial oxygen pressure and arterial ph does not influence the coagulation system ... | 1977 | 15952 |
| production of monospecific antibodies to rat liver ornithine decarboxylase and their use in turnover studies. | two forms of ornithine decarboxylase (l-ornithine carboxy-lyase, ec 4.1.1.17) were purified from the livers of rats which had been treated with thioacetamide for 16 h (for details, see miniprint to obenrader, m.f., and prouty, w. f. (1977) j. biol. chem. 252, 2860-2865). the enzyme was purified over 7,000-fold from liver cytosol with an overall yield of 8%. enzyme activity was eluted finally in two distinct fractions by chromatography on activated thiol-sepharose 4b. both forms appear to be dime ... | 1977 | 16005 |
| neurospora crassa glutamine synthetase. translation of specific messenger ribonucleic acid in a cell-free system derived from rabbit reticulocytes. | the total reticulocyte lysate cell-free protein-synthesizing system was incubated in the presence of neurospora crassa rna. with the aid of an antibody directed against purified n. crassa glutamine synthetase, the synthesis of a specific protein was detected. this protein precipitates with antiglutamine synthetase using both direct and indirect procedures, migrates with the same molecular weight as the monomer of n. crassa glutamine synthetase when subjected to acrylamide gel electrophoresis in ... | 1977 | 16013 |
| quantitative studies on the polarization optical properties of striated muscle. i. birefringence changes of rabbit psoas muscle in the transition from rigor to relaxed state. | the changes in birefringence in the rigor to relax transition of single triton-extracted rabbit psoas muscle fibers have been investigated with quantitative polarized light techniques. the total birefringence of rest lenght fibers in rigor was (1.46 +/- 0.08) x 10(-3) and increased to (1.67 +/- 0.05) x 10(-3) after mg-atp relaxation. pyrophosphate relaxation increased the total birefringence only slightly, whereas subsequent mg-atp relaxation elicited the maximum increase in birefringence. chang ... | 1976 | 16016 |
| an evaluation of elution techniques in the study of immune complex glomerulonephritis. | antigen and antibody from glomerular immune complex deposits in rabbits with experimental bovine serum albumin-(bsa) induced chronic serum sickness (css) were quantitated in elutes from kidneys in which a portion of the antigen and antibody had been radiolabeled. the largest quantities of 125i bsa eluted with 1 m roprionic acid at ph 2.7 (86%) and 0.1 m borate buffer at ph 11.25 (80%). however, these buffers yielded less functional anti-bsa antibody than 0.02 m citrate buffer at ph 3.2 (344 mug/ ... | 1977 | 16060 |
| studies on the monoamine oxidase of monkey brain. | | 1977 | 16088 |
| intestinal brush-border sucrase: ph-dependent effects of harmaline and alkali metal ions proceedings. | | 1977 | 16127 |
| adrenergic agents. 4. substituted phenoxypropanolamine derivatives as potential beta-adrenergic agonists. | a series of 1-(substituted phenoxy)-3-(tert-butylamino)-2-propanols in which the ring substituents were 3,4-dihydroxy (6f), 3- and 4-hydroxy (6g and 6h, respectively), 3-hydroxy-4-methylsulfonamido (6i), its 3,4-transposed isomer (6j), and 4-methylsulfonylmethyl (6k) was prepared and examined for beta-adrenergic agonist and/or antagonist properties. two of these compounds, 6f and 6j, were potent beta-adrenoreceptor agonists in in vitro tests that measure a compound's ability to relax guinea pig ... | 1977 | 16136 |
| the mechanism by which glucagon induces the release of amino acids from muscle and its relevance to fasting. | | 1977 | 16271 |
| phospholipases a and b activities of the oriental hornet (vespa orientalis) venom and venom apparatus. | | 1977 | 16362 |
| acid gamma-amylase of rabbit and human brain. | preparations of acidic gamma-amylase, which cleaved glycogen and maltose, were isolated from human and rabbit brain tissues. the specific activity of the gamma-amylase preparations from human brain was approximately twice higher than the activity of the enzyme from rabbit brain. in degradation of glycogen gamma-amylases from human and rabbit brain had the ph optima at ph 4.9 and 4.6 and with maltose as a substrate- at ph 4.3 and 4.1, respectively. gamma-amylases from both sources possessed the h ... | 1977 | 16385 |
| intracellular localization of the processes of biosynthesis and degradation of nadp in skeletal muscle. | in studies on intracellular nadp localization the process of nadp biosynthesis was observed in mitochondria and hyaloplasm of rabbit sceletal muscle cells. this synthesis was not found in microsomal and nuclear fractions. the seasonal alterations in the nad-kinase activity were established: in autumn and winter months nadp synthesis proceeded at the maximal rate in hyaloplasm; in sping months the higher specific activity was observed in mitochondrial fraction. the rate of nadp synthesis was 2-5 ... | 1977 | 16388 |
| role of lipid peroxides in the pathogenesis of arteriosclerosis. detoxication of lipid peroxides by the glutathione-peroxidase system in the aorta. | in aorta of intact rabbits the high activity of glutathione-peroxidase, which detoxicates lipoperoxides, was observed. in aorta of animals with pronounced experimental atheromatosis the enzyme activity did not distinctly differ from the control values. the animals with high initial content of glutathione-peroxidase in aorta were shown to be less subjected to the impairment in alimentary atherosclerosis. | 1976 | 16399 |
| effect of psychotropic preparations on the activity of ca- and mg-dependent atpase of the sarcoplasmic reticulum. | in sarcoplasmic reticulum of rabbit skeletal muscles the activity of ca2+, mg2+- dependent atpase was distinctly inhibited under effect of neuroleptic drugs - derivatives of phenothiazine and butyrophenone. the effect of tricyclic antidepressants was less pronounced. tranquilizers (derivatives of 1,4-benzodiazepine) inhibited the enzyme, but trioxazin was only slightly active. high concentrations of lithium salts and of psychostimulants caffeine and corasole were found to stimulate the ca2+, mg2 ... | 1976 | 16400 |
| acid-base and water-electrolyte status in animals with experimental tumors. | it is noted that rats with heren carcinoma show alkalization of blood, decreased ph levels of the urine, hypokalemia, hypocalcemia, hypomagnesiemia, sodium and water retention, increased kalium level in the liver. analogous changes are observed in rabbits with brown-pearce carcinoma. the organism of tumor-bearing rats responds to stress effects otherwise than the organism of normal animals. | 1977 | 16402 |
| effect of cardiovascular drugs on electrolyte metabolism (review of the literature). | | 1977 | 16403 |
| some characteristics of uric acid uptake by separated renal tubules of the rabbit. | | 1977 | 16454 |
| the metabolic effects of tienilic acid, a new diuretic with uricosuric properties in man and dog. | | 1977 | 16459 |
| antimicrobial and other properties of a new stabilized alkaline glutaraldehyde disinfectant/sterilizer. | the properties of stabilized alkaline 2% glutaraldehyde solution (sgs) are discussed. sgs is discussed with regard to its chemistry, antimicrobial properties, organic soil resistance, toxicity, corrosivity and chemical stability. sgs retains the maximum antimicrobial activity of alkaline glutaraldehyde solutions and the chemical stability heretofore observed only with acidic glutaraldehyde solutions. these improvements, along with the inherent resistance of glutaraldehyde to neutralization by or ... | 1977 | 16488 |
| the role of analgesics in respiratory depression: a rabbit model. | the study of the effect of analgesics in the newborn is difficult in the clinical situation and resort must be made to animals. pethidine given within 1 hour of delivery is believed to cause less depression than when the time interval is longer. this study investigates whether it is pethidine or its metabolites which cause respiratory depression by comparing the respiratory effects of pethidine and its metabolites in the newborn rabbit. fentanyl and buphrenorphine were also investigated as alter ... | 1977 | 16506 |
| formaldehyde formation as a metabolite of methoxyflurane. | the production of formaldehyde as a metabolite of enzymatic biotransformation of methoxyflurane was observed in vitro in hepatic microsomal preparations derived from japanese monkeys, rabbits and wistar strain rats. production rates of formaldehyde were 0.80-2.50 n moles/mg protein/min in the induced group which was pretreated with phenobarbitone, and 0.15-0.68 n moles/mg protein/min in the non-induced group. this reaction needed the presence of nadph and oxygen. formaldehyde production was almo ... | 1977 | 16507 |
| the splitting of sperm heads from tails in eight mammalian species and the measurement of their sizes. | ejaculated spermatozoa from man, the euopean wild boar and the bull, and spermatozoa from the cauda epididymes of the rabbit, rat, mouse, hamster and guinea pig were treated with a sonic bath, a sonic probe, trypsin with and without prior treatment with a sulphhydryl reagent, pronase and alkalis. the fragments produced were counted and sized in an accurately calibrated coulter counter, model zb industrial, before and after zaponin treatment to lyse accompanying debris and the peripheral cytoplas ... | 1977 | 16511 |
| alpha-adrenergic blocking action of fentanyl on the isolated aorta of the rabbit. | the contractile response of helically-cut strips of rabbit ascending aorta to transmural electrical stimulation was attenuated in a dose-dependent manner by treatment for 20 min with fentanyl, 10(-6) to 10(-5) m. fentanyl also shifted the dose-response curve of the contractile response of aorta to norepinephrine to the right. the response to transmural stimulation was more resistant to fentanyl than was the response to an equipotent dose of norepinephrine. the inhibitory effect of fentanyl was ... | 1977 | 16512 |
| detection of regional ischemia in perfused beating hearts by phosphorus nuclear magnetic resonance. | | 1977 | 16597 |
| interaction of nitromethane with reduced hepatic microsomal cytochrome p-450. | | 1977 | 16606 |
| intracellular distribution of ribonuclease activity during erythroid cell development. | five ribonuclease activities, separable by polyacrylamide gel electrophoresis, have been detected in erythroid bone marrow cells from anaemic rabbits. their intracellular distribution has been investigated and compared with that of the ribonucleases in reticulocytes. both the acid and alkaline ribonuclease activities of reticulocytes are much lower (30--50 fold) than those of bone marrow erythroid cells. the most marked decrease in enzyme activity occurs in the fractions containing ribosomes and ... | 1977 | 16651 |
| lactic acid as a factor in altering vascular reactivity. | it was shown that the constrictor responses to the electrostimulation of the isolated vessel segments were replaced by dilatation when the drugs were contained in the lactic acid solution. the capacity to constrictor effects was not lost completely, but these effects appeared in repsonse to the intensive stimulation. changes in the character of these reactions to the electrostimulation were connected with the changes in the ph of the solution, as well as with the specific action of lactic acid. | 1976 | 16674 |
| in vitro and in vivo studies of a stroma free hemoglobin solution as a potential blood substitute. | | 1977 | 16677 |
| cardiovascular effects of total hip placement in man. with observations on the effects of methylmethacrylate on the isolated rabbit heart. | the cardiovascular effects of total hip placement were evaluated in 10 surgical patients, aged 55 to 82, while receiving fluroxene-n2o-o2 anesthesia. the anesthetic regimen caused mild cardiovascular depression. the placement of the acrylic cement into the acetabulum and femoral shaft also induced mild cardiovascular depression, but these changes were not significant at p less than 0.05. in one 67-yr-old woman, there were significant reductions of cardiac output and stroke volume 2 min after the ... | 1977 | 16717 |
| oxygen uptake: intracellular effects of simulated ischemia on contractility of mammalian left ventricular cardiac muscle. | | 1977 | 16725 |
| effects of intracellular alkalosis on mammalian cardiac contractility. | | 1977 | 16726 |
| actin-induced local conformational change in the myosin molecule. i. effect of metal ions and nucleotides on the conformational change around a specific thiol group (s2) of heavy meromyosin. | as previously reported when a specific thiol group, s2, of myosin reacts with n-ethylmaleimide (nem), its ca2+-atpase activity is decreased. therefore, the reactivity of s2 can be estimated by measuring the decrement of the enzymatic activity. using the change in the reactivity as a structural probe, we investigated whether f-actin affects the conformation around the region containing s2 under physiological conditions (at neutral ph and low ionic strength). 1. experiments were carried out with h ... | 1977 | 16877 |
| identification of folate binding macromolecule in rabbit choroid plexus. | a macromolecular binder of folic acid and folic acid derivatives has been identified in the particulate fraction of homogenates of rabbit choroid plexus. within the choroid plexus, there are 2.3 nmol of folate-binding activity (binder) per g of tissue. the molecular weight of the folate binder complex, separated from the particulate fraction after solubilization with triton x-100, was 340,000 to 400,000 by sephadex gel filtration. the partially purified binder, when freed of endogenous folates, ... | 1977 | 16898 |
| effect of covalent attachment of polyethylene glycol on immunogenicity and circulating life of bovine liver catalase. | methoxypolyethylene glycols of 1900 daltons (peg-1900) or 5000 daltons (peg-5000) were covalently attached to bovine liver catalase using 2,4,6-trichloro-s-triazine as the coupling agent. rabbits were immunized by the intravenous and intramuscular routes with catalase modified by covalent attachment of peg-1900 to 43% of the amino groups (peg-1900-catalase). the intravenous antiserum did not yield detectable antibodies against peg-1900-catalase or native catalase, as determined by ouchterlony an ... | 1977 | 16907 |
| protein modification enzymes associated with the protein-synthesizing complex from rabbit reticulocytes. protein kinase, phosphoprotein phosphatase, and acetyltransferase. | a number of protein modification activities are present in the protein-synthesizing complex isolated from rabbit reticulocytes. these enzymes are solubilized by sedimentation of the ribosomes through buffered sucrose containing 0.5 m kcl, and have been partially purified from the high salt wash fraction by chromatography on deae-cellulose and phosphocellulose. the ribosomal-associated enzymatic activities include cyclic amp-regulated and cyclic nucloetide-independent protein kinase, phosphoprote ... | 1977 | 16914 |
| compartmentalization of adenosine 3':5'-monophosphate and adenosine 3':5'-monophosphate-dependent protein kinase in heart tissue. | in rabbit heart homogenates about 50% of the camp-dependent protein kinase activity was associated with the low speed particulate fraction. in homogenates of rat or beef heart this fraction represented approximately 30% of the activity. the percentage of the enzyme in the particulate fraction was not appreciably affected either by preparing more dilute homogenates or by aging homogenates for up to 2 h before centrifugation. the particulate enzyme was not solubilized at physiological ionic streng ... | 1977 | 16921 |
| effect of beta-adrenergic drugs on adenosine 3', 5'-monophosphate in rabbit vagus nerve. | | 1977 | 16990 |
| long term beta-adrenergic blockade reduces tyrosine hydroxylase and dopamine beta-hydroxylase activities in sympathetic ganglia. | | 1977 | 17075 |
| role of pco2 oscillations and chemoreceptors in ventilatory response to inhaled and infused co2. | we have previously shown in the anaesthetized rabbit that the ventilatory response to an increase in paco2 is greater if that increase is produced by intravenous infusion of hypercapnic blood than by inhalation of co2 (linton et al., 1976). the present set of experiments was designed to investigate the reason for this. it was found that the difference in ventilatory response observed in the intact rabbit was abolished by cutting the carotid sinus nerves or by eliminating the ph/paco2 oscillation ... | 1977 | 17144 |
| effect on gvh disease of in vitro donor cell pretreatment with rabbit antisera against various mouse lymphoid tissues. | | 1977 | 17187 |
| specific absorbed antithymocyte globulin for incubation treatment in human marrow transplantation. | the experimental data show that absorption of atg with liver-kidney homogenate and cll and lcl cells stepwise removed the hemopoietic toxicity, whereas the specific activity against t lymphocytes remained. although the mode of action of absorbed atg could not be tested in the first clinical case, the successful experiments in rodents together with the fact that the incubation treatment was tolerated by the patient may provide a new way of preventing fatal gvh reactions in man. | 1977 | 17192 |
| kinetic properties of membrane-bound enzymes. | | 1977 | 17207 |
| atpase activity and fluorescence of myometrial actomyosin in experimental uterine inertia. | a comparative study was performed for actomyosin complexes of the female rabbit myometrium in the state of labour (actomyosin of the control) and secondary uterine inertia (actomyosin of the model). under the secondary uterine inertia the activity of actomyosin ca2+- and mg2+-atpase decreases. when ph of the medium changes, atpase of control actomyosin has two peaks of the activity: at rh 6.0 and ph 9.0, that of the model at ph 6.0. actomyosin of the model and control differs by a degree and rat ... | 1977 | 17209 |
| role of salivary ribonuclease in pathogenesis of periodontosis. | in patients with periodontal disease a distinct increase in secretion of salivary acidic and alkaline rnaases was found. the rnaases activity in mixed saliva correlated with the intensity of degradation of periodontal tissues during loss of alveolar layer in aged wistar rats and the spontaneous periodontal disease in cats. in experiments with golden hamsters salivary rnaase was found to penetrate through mucosa in active form. the purified salivary rnaase inhibited the protein biosynthesis in ra ... | 1976 | 17223 |
| molecular evolution of glycogen phosphorylase and aminotransferases of vertebrate muscle tissue. | comparative biochemical studies on phosphorylase b, aspartate aminotransferase and alanine aminotransferase in muscles of various vertebrates (the lamprey lampetra fluviatilis, dogfish squalus acanthias, rays dasyatis pastinaca and raja clavata, teleosts scorpaena porcus, spicara smaris, esox lucius, tinca tinca, abramis brama, lucioperca lucioperca, cyprinus carpio, salmo ischchan, frog rana temporaria, tortoise testudo horsfieldi) revealed some peculiarties of their molecular evolution. it was ... | 1977 | 17251 |
| studies on the mechanism of the breakdown of the blood-aqueous barrier in the rabbit eye. | | 1977 | 17261 |
| susceptibility of laboratory and domestic animals to experimental infection with orungo virus. | laboratory and domestic animals: mice, hamsters, rabbits, sparrows, chickens and lambs were inoculated with orungo virus to determine their susceptibility as evidenced by clinical response, viraemia and antibody development. mice and hamsters circulated the virus and developed neutralising antibodies; clinical signs of disease included ruffled hair coat, hypersensitivity to sudden noise and hindleg paralysis. there was an age-related susceptibility to infection in these two animals. rabbits and ... | 1977 | 17281 |
| cecal motility in the rabbit. iii. duality of fecal excretion. | the production of soft pellets (caecotrophs) was studied in conjunction with feeding behaviour, biochemical changes in caecal contents, motility of the caeco-colic region and transit of digesta in the colon in rabbits fed ad lib. or receiving one or two daily meals. studies were carried out on animals either collared or free in their cages. ingestion of soft pellets was recorded from electrodes fixed in the esophageal wall. similar electrodes positioned on the caecum, proximal and distal colon a ... | 1976 | 17344 |
| thymic hormones: biochemistry, and biological and clinical activities. | | 1977 | 17354 |
| psychopharmacological implications of dopamine and dopamine antagonists: a critical evaluation of current evidence. | | 1977 | 17361 |
| effects of various neuroleptics on rabbit hyperthermia induced by n, n-dimethyltryptamine (dmt) and d-amphetamine. | the effects of various neuroleptics were studied on n, n-dimethyltryptamine (dmt, 3.2 mg/kg) and d-amphetamine (3.2 mg/kg) induced hyperthermia in the rabbit. complete dose-effect curves were obtained. the order of potency for antagonism of dmt-induced hyperthermia was: methiothepin greater than octoclothepin greater than or equal to oxyprothepin greater than perathiepin greater than dokloxythepin greater than mianserine greater than loxapine greater than oxypertine greater than chlorpromazine g ... | 1977 | 17371 |
| the blockade of serotonin uptake into synaptosomes:relationship to an interaction with monoamine oxidase inhibitors. | to test the hypothesis that the hyperpyrexia produced by meperidine and detromethorphan in rabbits pretreated with a monoamine oxidase inhibitor is related to inhibition of neuronal uptake of serotonin (5-hydroxytryptamine (5-ht)), fluoxetine (lilly 110140) was studied. this potent and specific 5-ht neuronal uptake blocker was administered to phenelzine-pretreated rabbits and found to produce a lethal hyperpyrexia in doses equal to or greater than 2.5 mg/kg. the order of potency in blocking 5-14 ... | 1977 | 17455 |
| morphine metabolism. v. isolation of separate glucuronyltransferase activities for morphine and p-nitrophenol from rabbit liver microsomes. | | 1977 | 17526 |
| glucuronidation and deglucuronidation reactions in hepatic and extrahepatic tissues during perinatal development. | the relative activities of uridine diphosphoglucuronyltransferase (udpgt) and beta-glucuronidase (betag) were measured during perinatal development of hepatic and extrahepatic tissues to determine the balance between glucuronidation and deglucuronidation reactions at different developmental stages. liver, lung, kidney, intestine, and placenta were studied in guinea pigs and rabbits. in general, betag activities exceeded those of udpgt in fetal tissues, whereas the converse was evident in adults. ... | 1977 | 17527 |
| acute hypotension due to carrageenan, arachidonic acid and slow reacting substance c in the rabbit: role of platelets and nature of pharmacological antagonism. | | 1977 | 17539 |
| study of the induction of thrombocyte adhesiveness in the presence of heparin. | an investigation of the thrombocytes adhesion after hellem (1960) showed that "in vitro" tests norepinephrine, epinephrine, histamine, serotonin and adenosine-diphosphate, when used in doses of 100-25,0 gamma/ml, were capable of raising the thrombocytes adhesion, while heparin administered in doses of 0.5-0.05 u/ml depressed and in a dose of 0.025 u/ml mildly activated this capacity of the thrombocytes. in the presence of heparin the ability of biogenic amines to induce the adhesion of thrombocy ... | 1976 | 17546 |
| glutamic-oxalacetic transaminase activity in seminal plasma of some domestic animals in dependence of ph value and concentration of l-aspartate (author's transl). | | 1976 | 17556 |
| circular dichroic and perturbation spectra of aromatic chromophores in rabbit tropomyosin. topography of tyrosine residues. | 1. difference spectra of tryosyl residues obtained on denaturation of tropomycosin with urea or guanidinium chloride indicate that strong hydrophobic environments exist in the native coiled-coil state. 2. solvent perturbation difference spectra indicate that tyrosyl residues are partially accessible to the solvent. the accessiblity decreases with increasing size of the solvent molecules. 3. spectral ph titration of tyrosyl residues cannot provide information on the tyrosyl accessibility because ... | 1977 | 17600 |
| angiotensin homologs and analogs as inhibitors of rabbit pulmonary angiotensin-converting enzyme. | | 1977 | 17604 |
| de novo alanine synthesis in isolated oxygen-deprived rabbit myocardium. | | 1977 | 17612 |
| carrageenan and thrombin trigger prostaglandin synthetase-independent aggregation of rabbit platelets: inhibition by phospholipase a2 inhibitors. | acetylsalicylic acid, salicylic acid and indomethacin were equally effective in inhibiting aggregation of plasma-free rabbit platelets induced by carrageenan and by thrombin. in contrast, only acetylsalicylic acid and indomethacin suppressed the accompanying formation of prostaglandin-like activities. blockade of aggregation required the presence of the inhibitors in the platelet preparation, whereas blockade of prostaglandin synthetase remained even when the inhibitors were washed out. prostagl ... | 1977 | 17672 |
| systems approach to vaginal delivery of drugs iv: methodology for determination of membrane surface ph. | a physical model including a diffusional layer in series with the membrane was developed for studying the possible differences between the ph at the membrane surface and that in the bulk solution. both the membrane-secreted substances (acids and bases) and buffer constituents in the bulk solutions are assumed to contribute to the surface ph. equations derived for this situation, together with experimental determinations of the acidic dissociation constant of the secreted material, the total secr ... | 1977 | 17716 |
| systems approach to vaginal delivery of drugs v: in situ vaginal absorption of 1-alkanoic acids. | the vaginal absorption of a homologous series of ionizable compounds, the 1-alkanoic acids, was studied using a perfusion method with a rib-cage cell surgically implanted in the rabbit vagina. the absorption rates of these compounds followed first-order kinetics. the physical model previously used for the 1-alkanols, but accounting for the pka and ph effects in the present case was employed in the analysis of the carboxylic acid data. the aqueous diffusion layer thickness was 0.031 cm. the perme ... | 1977 | 17717 |
| stimulation of erythropolesis by beta adrenergic agonists. ii. mechanism of action. | | 1977 | 17727 |
| the influence of h+ on lung permeability to 51cr edta proceedings. | | 1977 | 17731 |
| effects of prostaglandin antagonism on sodium arachidonate fever in rabbits. | 1. sodium arachidonate, the prostaglandin precursor substance, when injected intraventricularly into rabbits, results in dose-dependent hyperthermia, which is rapid in onset and of several hours duration. 2. arachidonate fever was inhibited by intraventricular injection of indomethacin, but not by the simultaneous intraventricular injection of either of the two prostaglandin antagonists sc 19220 or hr 546. 3. both antagonists effectively inhibited the fever induced by the intraventricular inject ... | 1977 | 17735 |
| hyperpolarizing effects of dopamine on chemoreceptor nerve endings from cat and rabbit carotid bodies in vitro. | 1. the effects of dopamine on dc potential changes recorded from the carotid sinus nerve were studied in vitro using carotid bodies and associated sinus nerves removed from anaesthetized cats and rabbits.2. the carotid body was placed in one compartment of a superfusion chamber and was superfused with buffered salt solution. the carotid sinus nerve was led into an adjoining compartment, containing lightweight mineral oil, for recording dc potential changes with chlorided silver electrodes.3. dop ... | 1977 | 17742 |
| absolute configuration of glycerol derivatives. 4. synthesis and pharmacological activity of chiral 2-alkylaminomethylbenzodioxans, competitive alpha-adrenergic antagonists. | the optical isomers of alpha-adrenergic receptor antagonists prosympal (2), piperoxan (3), and dibozane (4) were prepared by methods establishing the absolute configuration of each. (2s)-3(2'-hydroxyphenoxy)-1,2-propanediol ditosylate (10) was prepared from (2r)-3-tosyloxy-1,2-propanediol acetonide (6). intramolecular displacement afforded (2s)-tosyloxymethylbenzodioxan (2r)-11. reaction of (2r)-11 with the appropriate amine (diethylamine, piperidine, or piperazine) afforded the 2s isomers of 2, ... | 1977 | 17749 |
| potassium and intracellular ph. | recent work has clarified some of the complex interrelationships between cell ph and potassium. these studies have been limited by the techniques available for accurately measuring cell ph. at present it is obvious that intracellular ph is a major regulator of the cellular potassium concentration, but the precise relationship between these two is still uncertain. it has become increasingly clear, however, that no simple relationship exists between the intracellular to extracellular hydrogen ion ... | 1977 | 17762 |
| pharmacological characterization of the dopamine-mediated accumulation of cyclic amp in intact retina of rabbit. | | 1977 | 17798 |
| hydrolysis of cocaine in human plasma by cholinesterase. | | 1977 | 17804 |
| ion fluxes in hypoxic tissues. | | 1977 | 17814 |
| heterogeneity of staphylococcal enterotoxin a on isoelectric focusing and disc electrophoresis. | heterogeneity of purified staphylococcal enterotoxin a, obtained from a culture supernatant of staphylococcus aureus, strain 13n-2909, was demonstrated by isoelectric focusing. the toxin was composed of three immunologically identical fractions with isoelectric points of 6.5, 7.0 and approximately 8.0. heterogeneity of the toxin was also shown by disc electrophoresis. at ph 8.0 and 9.4 two major bands and a faint minor band were observed, while at ph 4.3 only one band was observed. the faster-mo ... | 1977 | 17815 |
| an analysis of factors influencing the isolation rate of herpes simplex virus. | attempts were made to improve the rate of isolation of herpes simplex virus (hsv) from clinical specimens by minimizing loss of virus infectivity during transportation and employing the most sensitive cells for isolation. basical analyses using standard strains of type 1 and type 2 hsv indicated that virus titer decrease was marked even at low temperatures in environments free of proteinous stabilizer such as normal serum or tissue extract, negating the generally held concept that hsv is stable ... | 1977 | 17816 |
| high-mountain hypoxia and blood regeneration in animals with experimental hyporegenerative anemia. | | 1977 | 17971 |
| effect of sodium taurocholate and ethanol on hydrogen ion absorption in rabbit esophagus. | | 1977 | 18006 |
| in vitro-phosphorylation of histones in chromatin of various tissues in relation to age (author's transl). | the influence of age on the structure of chromatin of various mammalian cells with modest or terminated mitotic activity has been examined. for this purpose chromatin from dog skeletal muscle, and human neuronal and glial cells, has been incubated together with an exogenous histone phosphokinase and atp-gamma32p, and the phosphate incorporated into the histones determined. for comparison, also free histone has been phosphorylated. the amount of phosphate incorporated into total histone is 16-18 ... | 1977 | 18036 |
| rabbit liver membrane phosphoprotein phosphatase. | | 1977 | 18090 |
| hydrogen peroxide formation and stoichiometry of hydroxylation reactions catalyzed by highly purified liver microsomal cytochrome p-450. | | 1977 | 18091 |
| activation of alkyldihydroxyacetone phosphate synthase by detergents. | | 1977 | 18102 |
| folate-dependent enzymes in cultured chinese hamster cells: folypolyglutamate synthetase and its absence in mutants auxotrophic for glycine + adenosine + thymidine. | | 1977 | 18110 |
| spectral evidence for 2,2,3-trichloro-oxirane formation during microsomal trichloroethylene oxidation. | during aerobic incubation of trichloroethylene with rabbit liver microsomes and nadph a difference absorption peak appears at 451-452 nm. trichloroethylene does not form a ligand absorption spectrum with hepatic microsomes reduced by dithionite, or in anaerobic incubates in the presence of nadph. addition of trichloroethylene epoxide (2,2,3-trichloro-oxirane) to reduced suspensions of rabbit liver microsomes produces high difference absorption at 452 nm, the optical ks being approximately 2 mm. ... | 1977 | 18130 |
| cardiac action of carazolol and methypranol in comparison with other beta-receptor blockers. | the new beta-blockers 4-(2-hydroxy-3-isopropyl-amino-propoxy)-carbazole (carazolol) and 1-(4-acetoxy-2,3,5-trimethylphenyloxy)-3-isopropylamino-propan-2-ol (methypranol, disorat) were compared with 14 well-known beta-blocking agents with regard to isoproterenol antagonism (equipotent doses in the rabbit i.v.), acute toxicity (ld50 in mice i.v.) and intrinsic sympathomimetic activity (increase in the heart rate of reserpinized rats i.p.). the following descending order for the equipotent beta-rec ... | 1977 | 18157 |
| protein kinases of rabbit and human erythrocyte membranes. solubilization and characterization. | two protein kinases (ec 2.7.1.37) from rabbit and one from human erythrocyte membranes have been solubilized with 0.5 m nacl. these enzymes have been partially purified by (nh4)2so4 fractionation and gel filtration. the rabbit membrane enzymes have apparent mr values of 100 000 and 30 000, as determined in the presence of 0.4 m nacl. in the absence of salt, these enzymes aggregate into high molecular weight species. the kinase from human erythrocyte membranes has an apparent mr of 30 000 and app ... | 1977 | 18184 |
| studies on (na+ +k+) activated atpase. xli. effects of n-ethylmaleimide on overall and partial reactions. | 1. preincubation with n-ethylmaleimide inhibits the overall activity of highly purified (na+ +k+)-atpase (atp phosphohydrolase, ec 3.6.1.3) preparations of rabbit kidney outer medulla. 2. this inhibition is decreased by addition of atp or 4-nitrophenylphosphate under non-phosphorylating conditions, and also by addition of adp or adenylylimidodiphosphate. 3. n-ethylmaleimide treatment leads to inhibition of k+-stimulated 4-nitrophenylphosphatase activity, na+-stimulated atpase activity, and phosp ... | 1977 | 18194 |
| a radioimmunoassay for 1-beta-d-arabinofuranosyluracil with reference to cross-reactivity of 1-beta-d-arabinofuranosylcytosine with an antibody. | antibodies directed against 1-beta-d-arabinofuranosyluracil have been produced in rabbits by immunization with a conjugate of 1-(5-o-succinyl-beta-d-arabinofuranosyl)uracil with human serum albumin. two of four antibodies so obtained showed high specificity for 1-beta-d-arabinofuranosyluracil and allowed the development of a sensitive and reliable radioimmunoassay for this substrate. on the other hand, one antibody had a high affinity for 1-beta-d-arabinofuranosylcytosine. the binding of 1-beta- ... | 1977 | 18280 |
| the effect of chronic frusemide administration on intracellular potassium, sodium and ph of cardiac and skeletal muscle. | 1. chronic administration of frusemide in large doses of 4 mg day-1 kg-1 for 3 weeks caused a significant reduction of cell water in rabbit cardiac and skeletal muscle. intracellular na+ concentration, intracellular ph and extracellular space was unchanged in both tissues. intracellular k+ concentration increased slightly in both cardiac and skeletal muscle. 2. it is concluded that frusemide does not reduce intracellular k+ concentration in cardiac or skeletal muscle of normal animals receiving ... | 1977 | 18316 |
| some factors affecting testosterone, dihydrotestosterone, 5 alpha-androstan-3 alpha,17 beta-diol and 5 alpha-androstan-3 beta,17 beta-diol secretion by invitro perfused rabbit testes. | intra-arterial infusion of testosterone-3h gave rise to tritiated dihydrotestosterone, 5 alpha-androstan-3 alpha,17 beta-diol and 5 alpha-androstan-3beta,17 beta-diol in spermatic venous effluent of the perfused rabbit testis-epididymis. mass spectrometric measurements confirmed that these four androgens were present in spermatic venous effluent of the perfused rabbit testis-epididymis. gas liquid chromatographic measurement showed that testosterone, dihydrotestosterone, 5 alpha-androstan-3 alph ... | 1975 | 18320 |
| brain monoamines act through the prostaglandin release to influence the body temperature. | in the present study, the thermal responses induced by intraventicular administration of pyrogen prostaglandin e1, the brain monoamines norepinephrine and serotonin, and the antipyretic sodium acetylsalicylate (aspirin) were measured in conscious rabbits to assess the possible involvement of these substances in fever production. the body temperatures, metabolic rate, respiratory evaporative heat loss and vasomotor activity in response to the administration of these drugs were measured. the resul ... | 1976 | 18325 |
| specific alpha-adrenoceptor blocking effect of droperidol on isolated smooth muscles. | the present study was conducted so as to obtain more insight into the controversies concerning the alpha-adrenoceptor blocking properties of droperidol, a short-acting neuroleptic agent used in neuroleptanalgesia. the effect of droperidol on the vasoconstriction induced by norepinephrine, sympathetic nerve stimulation, histamine and potassium ions was studied on isolated, perfused ear arteries; its effect on norepinephrine-induced contraction was studied on isolated aorta, spleen and vas deferen ... | 1977 | 18356 |
| relationship between the pain-relieving action of narcotic analgesics and their effect on respiration. | experiments with rabbits (30) and albino rats (110) demonstrated that morphine (1 mg/kg), promedol (trimeperidine) (2 mg/kg) and phentanyl (0.02 mg/kg), while raising by 21-24 per cent of the algesia threshold, produced an analgesic effect differeing in its duration (morphine-130 min, trimeperidine-70 min, phentanyl-17 min). this is attended by changes in respiration (greater on introduction of phentanyl, and lesser, following administration of morphine) and by shifts in the functional state of ... | 1976 | 18367 |
| effect of corticotropin on functional and metabolic processes in muscles. | changes of excitability, contractility, temperature, activity of oxydation-reduction enzymes, pyridine nucleotides, and of free fatty acids were studied in m. m. gastrocnemii of rabbits and rats during activity, after administration of 1 unit per 100 g of corticotropin (acth). within 30 min after administration, the acth did not alter the excitability of a neural-muscular system but increased its efficiency by means of stimulation of the free fatty acids usage. besides, the acth elicits no regul ... | 1977 | 18370 |
| autoradiographic studies of rabbit ova after fertilization with thymidine-h3 and -c14 labelled spermatozoa originating from different bucks. | rabbit spermatozoa were labelled in vivo injecting male rabbits with thymidine-h3 and thymidine-c14. ova fertilized with h3-labelled spermatozoa were found to contain more silver grains when they had cleaved several times than before cleavage. fertilized ova originating from rabbits that had been mated with both an h3- and c14-thymidine labelled buck carried both labels. an explanation for this phenomenon may be that additional spermatozoa in the perivitelline space of fertilized ova pass labell ... | 1977 | 18410 |
| absence of a prenidatory effect of luteinizing hormone releasing hormone (lhrh) in hamsters. | luteinizing hormone releasing hormone at high doses will terminate gestation in rats during early and midpregancy (ed50 approximately equal to 100 microgram/day) and rabbits during early pregnancy. early pregnancy in hamsters, in contradistinction, seems refractory to this effect. administration of lhrh up to massive doses (10 mg/day) over the first 3 or 7 days of pregnancy failed to affect the pregnancies in meaningful fashion. further, a single injection (100 mg) on day 5 had no effect on preg ... | 1977 | 18411 |
| affinity labeling of adenine nucleotide-related enzymes with reactive adenine nucleotide analogs. i. affinity labeling of glyceraldehyde 3-phosphate dehydrogenase and myokinase with a reactive amp analog. | rabbit muscle glyceraldehyde 3-phosphate dehydrogenase (gpd) and myokinase (mk) were rapidly inactivated by a reactive amp analog, n6-(p-bromoacetaminobenzyl)-amp, under mild conditions. complete inactivation was observed when 4 and 0.3 mol of the reagent with respect to enzyme were reacted with gpd and mk, respectively. the inactivation of both enzymes were favored at higher ph and the enzymes were protected by addition of adenine nucleotide substrate. modified gpd or mk had no affinity for am ... | 1977 | 18448 |