the reporting of statistical techniques in otolaryngology journals. | the domain of this study is the reporting of statistical analyses in the otolaryngology literature during 1983 and 1984. fewer than ten basic statistical procedures accounted for more than 90% of the statistical techniques reported. implications for authors, journals, and educators are discussed. we offer suggestions for imparting statistical skills that may be helpful in curriculum design, residency training, and continuing medical education planning. | 2013 | 3790284 |
[aerobic capacity estimated from heart rate under submaximal load: an indicator of complaints, personality, personal activity and social status]. | in 34 young females (mean: 21 years, range 18-30), working with vdts, maximum aerobic capacity (mac) was estimated by use of a cycle ergometer and astrand's nomogram. mac correlated with musculoskeletal complaints (-.29, p less than .05), eye complaints (-.36, p less than .05), personal activity (.38, p less than .05), personality dimensions: "imperturbability" (.41, p less than .01), "wellbeing" (.31, p less than .05), "traditionalism" (-.45, p less than .01) and "psychophysic constitution" (al ... | 2013 | 3811609 |
judgement in meat inspection. | | 2013 | 3660561 |
[topical minoxidil in the treatment of alopecia areata: dose-dependent response]. | | 2013 | 3623631 |
blood and neoplastic diseases. myelomatosis. | | 2014 | 4434121 |
a health care plan for east harlem--now. the baltimore experience: 80,000 ibm cards. | | 2015 | 4503791 |
management of catastrophic postoperative breakdown after massive oropharyngeal cancer surgery. survival in a perilous situation. | | 2015 | 4551237 |
a team approach to medical history. | | 2015 | 4507344 |
comparison of analytic methods for calculation of cerebral blood flow after intracarotid injection of 133 xe. | | 2015 | 4621448 |
amphetamines in the district of columbia. ii. patterns of abuse in an arrestee population. | | 2016 | 4751817 |
determination of serum total iron-binding capacity. | | 2016 | 4718973 |
[the scrub nurse's work in open-heart surgery in infants under 2 years of age]. | | 2008 | 2322966 |
electrocardiography in hypertensive heart disease. | | 2003 | 145315 |
[aneurysms of the abdominal aorta. clinical evaluation and therapeutic criteria]. | on the basis of their own experience and of the most recent acquisitions published in the literature, the authors report on aneurysms of the abdominal aorta which are observed with increasing frequency. after discussing the etiopathogenesis, they dwell on the principal clinical problems of the disease, especially those concerning early diagnosis. thanks to new acquisitions in vascular surgery, early detection may in fact allow of highly satisfactory therapeutic results. | 2008 | 2525451 |
[rendu-osler disease as a cause of gastrointestinal hemorrhage in a 9-year-old girl]. | | 2012 | 3497377 |
the diagnostic value of serum ferritin determinations for assessing iron status. | | 2012 | 3322966 |
variations in ambient temperature can lead to incorrect prediction of the luteinizing hormone surge using urinary dipsticks (ovustick). | to prevent laparoscopy from being timed after ovulation has occurred, the detection of luteinizing hormone (lh) surge in women being superovulated for in vitro fertilization is a key factor. urinary dipsticks provide patients with a simple means of monitoring their lh levels at home; however, many patients experience difficulties interpreting the blue color of these sticks and variations in color intensity. to investigate the temperature dependence of these lh urinary dipsticks, the ovustick tes ... | 2013 | 3580334 |
experience with bone marrow transplantation for severe aplastic anemia and leukemia. two years experience with 31 patients in zagreb (yugoslavia). | since 1983, twelve patients with severe aplastic anemia and nineteen patients with leukemia were treated with bone marrow transplantation. six patients with severe aplastic anemia are still alive at 300 to 1,210 days after transplantation, and twelve patients with leukemia are alive at 199 to 671 days. the incidence of gvhd was relatively high (60%). bacterial infections were the main causes of death. | 2013 | 3548836 |
omental protection of autogenous arterial reconstruction following femoral prosthetic graft infection. | vascular graft infections in the femoral region that require synchronous revascularization are generally reconstructed with prosthetic grafts via extra-anatomic routes. if in situ revascularization is required, then autologous tissue provides optimal results. a particular challenge in this circumstance is achieving soft tissue coverage of the reconstruction where wide and radical débridement has removed the tissues ordinarily used for this purpose. if muscle flaps are not available or possible, ... | 2014 | 4009844 |
origin of immune diversity: genetic variation and selection. | | 2014 | 3927822 |
[artero-venous angiodysplasia at the splenic hylum: contribution to the knowledge of pre-hepatic artero-venous angiodysplasias with portal hypertension]. | | 2014 | 4080430 |
[experimental study of radioimmunoassay of total serum thyroxine. (1)]. | | 2015 | 4475877 |
laboratory recognition of coronary artery disease (with a review of the surgical treatment). | | 2015 | 4365693 |
[surgical treatment of vitreo-retinal abscess after cataract extraction]. | | 2011 | 3153876 |
influence of antibiotics on the faecal excretion of bile pigments in healthy subjects. | we have evaluated the effects of 10 antibiotics, given orally for 6 days to healthy subjects, on faecal excretion of urobilinogen. intake of bacitracin, vancomycin, clindamycin, erythromycin, and ampicillin resulted in a pronounced suppression of the faecal excretion of urobilinogen (p less than 0.05). intake of doxycycline, metronidazole, nalidixic acid, ofloxacin, and trimethoprim/sulphamethoxazole had no significant effect. the effects of three antibiotics-ampicillin, clindamycin, and metroni ... | 2013 | 3775264 |
varied appearance of cardiac pseudoaneurysms on blood pool images. | three cases of cardiac pseudoaneurysms were presented, with findings at the time of gated blood pool imaging. in only one of three was there the finding of a small neck connecting the ventricular cavity with the pseudoaneurysm. in the other two patients, there was a considerably larger communication. the size of the pseudoaneurysm itself was also of little diagnostic assistance. in one case it was small, while in a second patient it was larger in size. the third case revealed a pseudoaneurysm of ... | 2013 | 3595025 |
varied appearance of cardiac pseudoaneurysms on blood pool images. | three cases of cardiac pseudoaneurysms were presented, with findings at the time of gated blood pool imaging. in only one of three was there the finding of a small neck connecting the ventricular cavity with the pseudoaneurysm. in the other two patients, there was a considerably larger communication. the size of the pseudoaneurysm itself was also of little diagnostic assistance. in one case it was small, while in a second patient it was larger in size. the third case revealed a pseudoaneurysm of ... | 2013 | 3595025 |
[crushing and avulsions of segments of the limbs in patients with polytrauma]. | | 2014 | 4069611 |
autonomic function in myotonic dystrophy. | | 2014 | 3966879 |
gamma-radiolysis of aqueous solution of proline. | gamma-radiolysis of 0.05 m neutral proline solution was investigated. as the main reaction of proline radiolysis in oxygenated solutions, the hydroxylation reactions leading to hydroxyproline formation and the reactions leading to the total destruction of the pyrrolidine ring were shown. in oxygen-free solutions the yield of these reactions decreased; in this medium combination reactions giving rise to higher molecular weight combination products (up to approx. 1500) belong to the most important ... | 2002 | 126589 |
[preliminary study on the pharmacokinetics of aminophylline controlled-release tablets]. | | 2011 | 3197163 |
squamous cell cancer of the liver arising from a solitary benign nonparasitic hepatic cyst. | a case of squamous cell carcinoma arising from a solitary benign nonparasitic hepatic cyst (sbnhc) causing bile duct obstruction is presented. a review of the literature regarding sbnhc suggests that, although these lesions may appear benign, they may also undergo metaplastic and subsequent malignant transformation. this appears to be particularly true when the sbnhc is lined with squamous epithelium. once squamous cell carcinoma arises from one of these lesions, the prognosis is extremely grave ... | 2012 | 3279761 |
traumatic diaphragmatic hernias--pitfalls in the barium meal. | | 2013 | 3770913 |
[appearance and quantitative variations of hepatic glycogen in chick embryo]. | | 2016 | 4974511 |
acute coronary occlusion and reperfusion. reliability of angiographic classification and grading. | 93 patients with acute myocardial infarction entered into a multicentre, randomised fibrinolytic therapy study underwent coronary angiography prior to treatment with intracoronary streptokinase or intravenous anisoylated plasminogen streptokinase activator complex (apsac). subsequent to administration of fibrinolytic therapy, coronary arteriography of the infarct-related artery was also performed at 15, 30, 45, 60, 75 and 90 minutes. angiographically defined coronary perfusion was graded as foll ... | 2012 | 3315585 |
[professor aleksandr vasilievich saveliev (on his 70th birthday)]. | | 2014 | 4243994 |
technical possibilities in the school situation for the education of hearing-impaired children. | for hearing-impaired children, the main problem in the classroom is the signal-to-noise ratio. to improve the signal-to-noise ratio, several class systems have been developed, three of which have been investigated in this study. the systems are shown to be equivalent in a situation without a channel for pupil response. application of such pupil response channels will decrease the improvement in signal-to-noise ratio brought about by the class system. it is argued that the choice among several co ... | 2006 | 1610313 |
percutaneous transluminal coronary angioplasty of the "culprit lesion" for management of unstable angina pectoris in patients with multivessel coronary artery disease. | the efficacy of 1-vessel percutaneous transluminal coronary angioplasty (ptca) directed at the presumed angina-producing stenosis, or "culprit lesion," in the treatment of unstable angina pectoris and multivessel coronary artery disease (cad) was assessed in 27 patients with unstable angina refractory to optimal medical therapy. eighteen patients had 2-vessel and 9 had 3-vessel cad. the culprit lesion was identified in all patients by analysis of the qualitative appearance of the coronary lesion ... | 2010 | 2944366 |
alleviating children's postoperative pain. | | 2011 | 3131620 |
single- and dual-photon absorptiometry in osteoporosis and osteomalacia. | single- and dual-photon absorptiometric methods have been used in the past to identify populations at risk for bone loss, to define the osteoporotic syndrome in terms of bone mass, and to evaluate treatment regimens to prevent bone loss. technical improvements have made these procedures available for the nontraumatic measurement of bone mineral in the management of the individual patient suspected of having osteoporosis or other bone loss. this requires a different approach to data interpretatio ... | 2012 | 3317845 |
a longitudinal study of 21 subjects with coronary heart disease: life changes, catecholamine excretion and related biochemical reactions. | | 2015 | 4644659 |
reliability of ocular tumor diagnosis with ultrasound. | | 2016 | 4784909 |
hypophosphatasia: report of a case with unique oral manifestations. | | 2012 | 3256598 |
electro-clinical correlations between latent tetany and neuroses. | | 2014 | 4103521 |
[further development of the social service of the physician to a common medical social service--a requirement of the times? thoughts in regard to the topic from the standpoint of the public health service (author's transl)]. | | 2002 | 135231 |
presynaptic receptor systems on cardiac sympathetic nerves. | | 2003 | 222983 |
register of psychiatrists in training. | | 2005 | 1276791 |
the role of the surrounding tissue in the propagation of waves through the arterial system. | a theoretical analysis of the flow in arteries is presented, taking into consideration the role played by the surrounding tissues in determining the speed of propagatoion and the damping of the blood pressure pulse. this study was undertaken (a) to exhibit a method of computing the flow properties with a more nearly accurate model, (b) to see if the displacement on the skin would be related to the arterial wall displacement, and hence to pressure, velocity and flow rate of blood in the artery, a ... | 2005 | 1231056 |
don't smoke smoke smoke that cigarette. | | 2005 | 1070373 |
["feature cards": a simple and logical system for clinical research]. | | 2005 | 554113 |
[nurses and professional secret]. | | 2006 | 3645907 |
[nurses and professional secret]. | | 2006 | 3645907 |
rural advanced practice nurses: a decade of growth. | | 2006 | 1764326 |
[long-term outcome of a hospital series of patients with atrio-ventricular accessory pathway]. | ninety five patients with a mean age of 39 +/- 19 years, 82 of whom were symptomatic, having an accessory atrioventricular bidirectional conduction pathway (wpw syndrome: 77; "concealed": 18) were followed up for an average of 7.3 +/- 2.6 years. the objectives were to analyse: the incidence and causes of death and the possible predictive factors of death due to the wpw syndrome--the influence of medical treatment and type of medication on survival and symptoms. of the 8 cardiac deaths, 6 seemed ... | 2006 | 1363771 |
[diagnosis of variants of wegener's granulomatosis]. | | 2009 | 2763183 |
nodular fascitis of the mandible in a child. | nodular fascitis is an unusual, tumor-like, proliferative, fibroblastic lesion with infiltrative properties. we describe a case of nodular fascitis appearing in the mandible of a 2-year-old boy. a brief review of the literature on this lesion arising from intra or perioral regions, and the importance of differential diagnosis for this lesions are discussed. | 2010 | 3091735 |
electrical membrane breakdown: a possible mediator of the actions of electroconvulsive therapy. | the voltage across electrodes during electroconvulsive therapy (ect) is two or three orders of magnitude greater than the membrane potential levels at which electrical breakdown occurs. this paper attempts to relate the interelectrode voltage to the membrane potential of individual neurones. for certain neurones the calculated values exceed the breakdown level. the study indicates that electrical breakdown does take place during ect. it is suggested that electrical breakdown could explain some e ... | 2012 | 3320698 |
results of treating malignant melanoma intralymphatically with radioactive isotopes. | | 2015 | 4372734 |
fallacies of medially wedged heel for valgus foot. | | 2004 | 521647 |
wisc-r versus wisc for black children suspected of learning or behavioral disorders. | | 2004 | 438637 |
psychiatric morbidity in a sample of a london coroner's open verdicts. | one hundred and thirty-four deaths recorded as open verdicts in the inner west london coroner's district during 1969 and 1970 have been surveyed for evidence of mental illness. for 110 (82 per cent) of these deaths the probable verdicts were suicide or accident and they were reclassified as undetermined deaths. of these deaths 73 per cent were diagnosed as mentally ill, 54 per cent were receiving medical treatment for psychological symptoms before death, 42 per cent had a history of psychiatric ... | 2005 | 1182365 |
phloroglucinol derivatives of eleven dryopteris species from japan. | | 2005 | 1197418 |
the educational process at the mount sinai school of medicine: the first 25 years. | although the charter for the school of medicine was signed in 1963, and active recruitment of faculty commenced almost immediately, the recruitment of students, in fact, did not begin until several years later, with admission of a first-year and a third-year class in september 1968. from that time to the present, the class size has increased from a small, carefully selected group of 36 first-year students to its current size of 115 students in each of the basic science years and 132 students in ... | 2006 | 2685587 |
effect of the vibratory acoustic stimulation on fetal heart rate patterns of premature fetuses. | the purpose of this study was to examine the heart rate patterns before and after a standardized external vibratory acoustic stimulation in a group of 24 healthy premature fetuses at 32-35 weeks gestational age. fhr was analysed on line by sonicaid computer system 8000. a significant increase in the number of accelerations and an increase of variation after stimulus were observed. all other fhr patterns such as baseline, high and low episodes did not change significantly. | 2006 | 1346598 |
grading white matter lesions on ct and mri: a simple scale. | we developed and tested a simple three-point scale for grading white matter lesions in anterior and posterior regions of the brain. twenty four ct scans and 24 mri scans were separately judged by 11 and five observers, respectively, on the presence and severity of white matter lesions. the observers were radiologists and neurologists. for ct scans, these periventricular changes were graded according to their extent as absent, or partly involving the white matter, or extending up to the subcortic ... | 2008 | 2292703 |
prenatal diagnosis of mohr syndrome by ultrasonography. | a case of prenatal diagnosis of mohr syndrome is presented. the ultrasound examination was indicated by the previous birth of an affected brother. the need for genetic counselling is stressed, when polydactyly is observed accidentally at ultrasound examination during pregnancy. | 2014 | 3911193 |
primary tissue failure in pericardial heart valves. | a number of centers have recorded a significant incidence of primary tissue failure with the standard ionescu-shiley pericardial valve. in most cases severe regurgitation was caused by leaflet tears adjacent to the edge of the cloth-covered stent. our early clinical experience (up to 4 years' follow-up) with two new pericardial valves (ionescu-shiley low-profile and hancock pericardial valves) has shown that primary tissue failure also occurs in these new valves. in vitro accelerated fatigue stu ... | 2012 | 3626599 |
inhibition of erythrocyte sickling by cystamine, a thiol reagent. | incubation of sickle cells with cystamine, a thiol reagnet, resulted in the formation of an intracellular s-ethylamine derivative. the rate of the reaction was dependent upon the cystamine concentration, the temperature, and the duration of the incubation. the cystamine-treated cells demonstrated a marked inhibition of sickling under hypoxic conditions, a decrease in their mean corpuscular hemoglobin concentration, and a significant increase in their oxygen affinity. the oxygen affinity of these ... | 2002 | 135260 |
a comparison of wisc and wisc-r subtest scatter. | | 2004 | 438638 |
isolation of maltopentaose from corn syrup by chromatography on granulated hydroxylapatite. | | 2004 | 443535 |
[lipid and mineral metabolism and morbidity with temporary loss of work capacity in miners]. | examination is performed on 87 miners from mine for copper production subject to intensive local vibrations with average rate of increase (k) of the norms for the individual octave frequencies 2.4 times for 3 h exposure of the working shift, as well as to intensive noise--113-115 db/a equivalent level, general dust--23 mg/m3, fine dust--3.5 mg/m3 and fine quartz--0.43 mg/m3. there are data for vibration effect--changes in the cold test, vibration sensoriness, ultra sound sonometry, in all miners ... | 2005 | 1364539 |
determination of ring- and n-substituted amphetamines as heptafluorobutyryl derivatives. | an improved derivatization method for analysing 12 ring- and n-substituted amphetamine-derivatives in body fluids or seized materials by gas chromatograph combined either with mass spectrometer, electron capture or nitrogen phosphorus detector is presented. heptafluorobutyric anhydride is used as derivatization reagent. no heating or standing period is needed in this procedure. most of the drugs considered were distinguishable from each other according to their retention times and all of them ac ... | 2006 | 1855720 |
determination of ring- and n-substituted amphetamines as heptafluorobutyryl derivatives. | an improved derivatization method for analysing 12 ring- and n-substituted amphetamine-derivatives in body fluids or seized materials by gas chromatograph combined either with mass spectrometer, electron capture or nitrogen phosphorus detector is presented. heptafluorobutyric anhydride is used as derivatization reagent. no heating or standing period is needed in this procedure. most of the drugs considered were distinguishable from each other according to their retention times and all of them ac ... | 2006 | 1855720 |
erythrocyte incorporation of ingested 58-iron by infants. | the least abundant stable isotope of iron, 58fe (natural abundance 0.322 weight %), was administered orally to infants to explore the feasibility of using a stable rather than a radioisotope in studies of iron absorption. the dose of 58fe was given between feedings at age 126 days. the mass isotope ratio, 58fe/57fe, was determined in blood by inductively coupled plasma mass spectroscopy and at ages 140, 168, and 196 days. the percentage of the 58fe dose entering the circulation (3.2 to 16.0%) wa ... | 2012 | 3412846 |
[individualized selection of anti-angina drugs by applying self-controlled graded walking]. | | 2008 | 2395257 |
psycho-social aspects of recovery from coronary heart disease: a review. | | 2003 | 329420 |
acute toxicity of mevinphos to gerbils. | | 2005 | 1273839 |
acrylic resin finger prosthesis. | a technique is described for the prosthetic replacement of two fingers using acrylic resin. retention was obtained using finger rings. the stages of the technique are outlined. advantages and disadvantages are briefly stated. | 2006 | 1484252 |
effect of membrane additives on vesicle fusion. | a large variety of alkyl derivatives were found to either slow or block the low-temperature induced fusion of dipalmitoylphosphatidylcholine small unilamellar vesicles (dppc suv) when incorporated into the suv bilayer at five mol%. only corn oil was fusogenic. | 2006 | 2758525 |
ototoxicity of an ototopic preparation--experimental results and clinical facts. | the ototoxicity of "cortisporin otic suspension" containing 3.5 ml neomycin base, 10,000 units/ml polymyxin b was studied using the baboon (papio ursinus) as an experimental animal. inner and outer hair cell loss occurred in all cochleas of the ears which received cortisporin. most lesions were confined to the basal turn of the organ of corti. separate evaluation of polymyxin b and neomycin at the same concentration as in cortisporin showed that polymyxin b produced greater cochlear damage. the ... | 2007 | 1950546 |
[malaria in 1985: new recommendations]. | | 2013 | 4042266 |
quality of life in end-stage renal disease: a reexamination. | a self-administered questionnaire assessing both objective and subjective quality of life was completed by 489 end-stage renal disease (esrd) patients in a representative sample of an entire network. patients differed in both objective and subjective quality of life when examined as a function of treatment modality. the quality of life is similar for successful transplant and home hemodialysis patients; these patients appear to fare better than other treatment groups on both objective and subjec ... | 2008 | 2493190 |
aids: the challenge and the hope. | | 2008 | 3235984 |
[osseointegrated implants. core-vent and screw-vent]. | 51 variously edentolous patients have been treated by placing 143 core-vent and screw-vent osteointegrated implants. the follow-up ranges from 8 to 20 months. just one implant was removed. the authors explain their surgical method and their considerations about the two different kinds of implants. some clinical cases are reported. | 2009 | 2700964 |
[breast cancer in young women with a history of breast cancer in their mother]. | in this norwegian case-control study, it was found that the relative risk of getting breast cancer among women whose mothers had had this cancer is 3.7. the data for this study was taken from all the 105 cases of breast cancer diagnosed in norway over a 1 year period in 1984-85. this was compared with a control group of 210 picked randomly from the general population, which matched the test group as to age, oral contraceptive usage, etc. diagnostic and surgical records were made available by the ... | 2013 | 3824281 |
advanced adenocarcinoma of the fallopian tube. | | 2016 | 4725956 |
[remarks about tympanoplastic (personel methods) (author's transl)]. | a valuable aeration of the middle ear from the eustachian tube to the aditus ad antrum is realized by the implantation of a one inch long part of the vena saphena magna. a tube of polyethylene introduced in the ostium of the eustachian tube maintains the vein in position during 3-4 weeks, the intima of the vein is an empeachment for synechia with the promontorium. by a special incision the deeper tissues of the ear are formed to a pediculated flap. the splitting of this flap enables the formatio ... | 2002 | 135160 |
[improvement of drug therapy for essential hypertension]. | only 20-30% out of all the patients suffering from hypertension have sufficient treatment. in spite of full treatment a small part of the patients (about 5%) shows an insatisfactory result. subjective factors are more important: on the part of physicians doubtfulness about choice of medicaments and imperfect consistency to long-term treatment, on the part of patients inadequate co-operation. the use of 9 selected antihypertensive medicaments is suggested in a decided order under rational aspects ... | 2004 | 516837 |
traumatic fat necrosis of the face in children. | | 2004 | 444773 |
[scleroderma in plaques. immunological and visceral disturbances (author's transl)]. | | 2004 | 305741 |
[utilization of computer technic and methods of medical cybernetics in practical work of the instititutions of the ministry of public health of rsfsr]. | | 2005 | 1273637 |
[arterial occlusions in the leg--when can and should the surgeon operate?]. | | 2005 | 1196076 |
verbal effects in children's visual recognition memory. | preschool children were shown line drawings of 12 pairs of items and were asked to describe them. each child saw elaborated and unelaborated pictures (items interacting vs. not interacting). the children's descriptions were rated as elaborated or unelaborated (interactions mentioned vs. not mentioned). 1 week later, a recognition test was given, with choices between an elaborated and an unelaborated picture for each pair. in general, recognition accuracy was best for elaborated pictures given el ... | 2005 | 1183272 |
synthesis of an active hydroxylated glutethimide metabolite and some related analogs with sedative-hypnotic and anticonvulsant properties. | two synthetic pathways are described for the preparation of 4-hydroxy-2-ethyl-2-phenylglutarimide (2), an active hydroxylated metabolite of glutethimide (1). fourteen other glutethimide analogs were also synthesized and tested for biological activity. most of the analogs exhibited sedative-hypnotic properties and compound 2 possessed the greatest activity compared to the parent drug. 4-amino-2-ethyl-2-phenylglutarimide and 4-hydroxy-2-ethyl-2-phenylglutaconimide (13) exhibited the greatest poten ... | 2005 | 1151995 |
improved methodology and precision using a straight base line technique for the quantitation of proteins by two dimensional immunoelectrophoresis. | | 2005 | 1112067 |
restoring teeth with large complex amalgams rather than castings. | | 2005 | 1065128 |
[cysts and fistulas of embryonal origin of the face]. | | 2005 | 1064061 |
[cardiology. introduction]. | | 2005 | 545628 |
[ulcers of the greater curvature of the stomach (author's transl)]. | | 2005 | 549065 |
inhibition of interleukin-2-induced tumor necrosis factor release by dexamethasone: prevention of an acquired neutrophil chemotaxis defect and differential suppression of interleukin-2-associated side effects. | high concentrations of tumor necrosis factor (tnf) alpha have been detected in the plasma of patients undergoing immunotherapy with interleukin 2 (il-2), suggesting that this cytokine may play a role in the fever and shocklike state induced by the administration of high-dose il-2. dexamethasone has been shown to inhibit the synthesis of tnf by monocytes activated in vitro by endotoxin. to determine if dexamethasone can exert a similar suppressive effect on il-2-induced tnf synthesis in vivo, the ... | 2006 | 2242421 |