| sporotrichosis. | sporotrichosis is a deep fungal disease caused by a dimorphic fungus, sporothrix schenckii. it occurs more frequently in the tropical and subtropical areas and is mainly characterized by nodular lesions of cutaneous and subcutaneous tissues and adjacent lymphatics that suppurate and ulcerate. infection occurs by manipulation of contaminated soil, cats, or some wild animals or by inhalation of spores. itraconazole is the best drug for treatment of sporotrichosis. | 2007 | 17350497 |
| in vitro susceptibility of sporothrix schenckii to six antifungal agents determined using three different methods. | the in vitro susceptibility of sporothrix schenckii to antifungal drugs has been determined with three different methods. nineteen peruvian clinical isolates of s. schenckii were tested against amphotericin b (ab), flucytosine (fc), fluconazole (fz), itraconazole (iz), voriconazole (vz), and ketoconazole (kz). modified nccls m38-a, sensititre yeastone (syo), and atb fungus 2 (atbf2) methods were used to determine the mics. atcc isolates of candida parapsilosis, candida krusei, and aspergillus fl ... | 2007 | 17438048 |
| sporotrichosis in north-east india. | reports on the occurrence of sporotrichosis in some parts of north-east india are scarce. we report here five cases of lymphocutaneous sporotrichosis from north-east india, including one from sikkim state and four from distant places in the north-eastern part of west bengal. all patients were full or part-time farmers or gardeners. diagnosis of sporotrichosis was confirmed by isolation of sporothrix schenckii in culture and in vitro conversion of the isolates to yeast form. the cases were treate ... | 2007 | 17472617 |
| mycological evaluation of bronchoalveolar lavage in cats with respiratory signs from rio de janeiro, brazil. | twenty-three cats with respiratory signs who had domiciliary contact with cats with sporotrichosis were studied. sneezing was the predominant extracutaneous sign. twelve cats had no skin lesions and 11 had ulcerated skin lesions. mycological culture of material obtained from the nasal cavity, oral cavity, bronchoalveolar lavage (bal) and skin lesions, when present, was performed for all cats. in the case of autopsy, lung fragments were cultured. sporothrix schenckii was isolated from four of the ... | 2007 | 17472619 |
| a rose by any other name. | a 40-year-old man visited haiti in the winter. his visit was uneventful, and he went swimming in the ocean. a week after his return he developed a small "pimple" on his right fifth finger. this condition progressed for several weeks, with new lesions developing over the extensor surface of his forearm and in the antecubital fossa. he had tender axillary adenopathy. the patient started a new job when he returned from haiti, working 4 days per week in a greenhouse. he denied any fever, chills, or ... | 2007 | 17483658 |
| [in vitro susceptibility of isolates of sporothrix schenckii to terbinafine and itraconazole]. | the study objective was to determine the in vitro activity of terbinafine and itraconazole through the microdilution technique in broth (ncclsm27-a2), adapted for dimorphic fungus, in relation to 12 isolates of sporothrix schenckii. six were from feline sporotrichosis, three from human sporotrichosis, one from a dog and two from human isolates originating from instituto oswaldo cruz. the inoculum and antifungal concentrates were distributed on microplates that were incubated at 35 degrees c for ... | 2007 | 17486256 |
| successful treatment of nasal sporotrichosis in a dog. | sporotrichosis is an uncommon mycosis of dogs caused by sporothrix schenckii. this report details the diagnosis and treatment of intranasal sporotrichosis in a dog presented for a loss of smell, sneezing, and nasal congestion. following 6 months of itraconazole treatment, a computed tomography scan showed a complete resolution of previously identified abnormalities. | 2007 | 17494369 |
| successful treatment of a disseminated sporothrix schenckii infection and in vitro analysis for antifungal susceptibility testing. | we report a case of a diabetic patient with localized osteoarticular sporotrichosis followed by widespread dissemination of the infection, which was successfully treated with amphotericin b. in addition, we evaluated the in vitro antifungal activity of 4 agents against both the mycelial and the yeast forms of the isolated fungus. | 2007 | 17498572 |
| typing of histoplasma capsulatum strains by fatty acid profile analysis. | the performance of fatty acid profiling for strain differentiation of histoplasma capsulatum was assessed. total fatty acids were isolated from the yeast-phase cells of seven stock and two previously unreported clinical strains of h. capsulatum var. capsulatum, as well as from one unreported clinical strain and one stock strain of h. capsulatum var. duboisii, and one strain of each of three other dimorphic zoopathogenic fungal species, blastomyces dermatitidis, paracoccidioides brasiliensis and ... | 2007 | 17510264 |
| cutaneous sporotrichosis of face: polymorphism and reactivation after intralesional triamcinolone. | cutaneous sporotrichosis, a subcutaneous mycotic infection is caused by the saprophytic, dimorphic fungus sporothrix schenckii. it commonly presents as lymphocutaneous or fixed cutaneous lesions involving the upper extremities with facial lesions being seen more often in children. the lesions are polymorphic. the therapeutic response to saturated solution of potassium iodide is almost diagnostic. we describe a culture-proven case of cutaneous sporotrichosis of the face mimicking lupus vulgaris i ... | 2007 | 17558054 |
| antifungal activity in triterpene glycosides from the sea cucumber actinopyga lecanora. | bioassay-guided fractionation of methanol extract of sea cucumber actinopyga lecanora led to the isolation of a new triterpene glycoside (1), along with two known glycosides holothurin b (3) and holothurin a (4). the structure has been elucidated on the basis of extensive 2d nmr spectroscopic analysis. the saponin (3) showed in vitro antifungal activity against all the twenty fungal test isolates including atcc strain and was found to be most effective against trychophyton mentagrophytes and spo ... | 2007 | 17587569 |
| sporotrichosis in iran. | this report describes a 23 year-old male florist gardener diagnosed with subcutaneous sporotrichosis caused by the dimorphic pathogenic soil fungus sporothrix schenckii. the patient had several small skin lesions over the left upper arm with ascendant chains of enlarged lymph nodes.sporothrix schenckii was detected from clinical samples by direct microscopy and culture and its ability to switch from mould to yeast form at 37 degrees c. the patient was successfully treated with long-term potassiu ... | 2007 | 17592890 |
| cutaneous and meningeal sporotrichosis in a hiv patient. | a male patient with hiv and past history of tuberculosis and suspected neurotoxoplasmosis was admitted to the hospital with vomiting and small nodules through all his body. few of the nodules were found forming chains of enlarged lymphatic vessels, especially on lesions located on the limbs. some of the nodules were ulcerated with a serosanguineous discharge. collected samples from ulcerated and the nodular lesions showed the presence of sporothrix schenckii in culture. although all hemocultures ... | 2007 | 17604439 |
| immunoglobulins g, m, and a against sporothrix schenckii exoantigens in patients with sporotrichosis before and during treatment with itraconazole. | sporotrichosis is an important subcutaneous mycosis, with an increasing worldwide incidence. however, few data are available regarding the immunological aspects of sporothrix schenckii infection, particularly the humoral responses to the fungus. in this study we measured immunoglobulin g (igg), igm, and iga in sera from 41 patients with sporotrichosis before antifungal treatment and from another 35 patients with sporotrichosis during itraconazole treatment by using a recently described s. schenc ... | 2007 | 17634504 |
| [effect of potassium iodide on the immune response in the sporotrichosis.]. | potassium iodide (ki), the specific treatment for sporotrichosis, apparently does not have a direct action on sporothrix schenckii. the spontaneous healing and the variability of the clinical presentation in the disease have strengthened the idea that the ki rather interacts with the immune response of the host. the phagocytic process is inefficient in individuals with sporotrichosis in whom the microbicidal mechanism of halogenation fails to control the disease. there is evidence that blocking ... | 1997 | 17655382 |
| sporothrix brasiliensis, s. globosa, and s. mexicana, three new sporothrix species of clinical interest. | sporothrix schenckii is the species responsible for sporotrichosis, a fungal infection caused by the traumatic implantation of this dimorphic fungus. recent molecular studies have demonstrated that this species constitutes a complex of numerous phylogenetic species. since the delineation of such species could be of extreme importance from a clinical point of view, we have studied a total of 127 isolates, most of which were received as s. schenckii, including the available type strains of species ... | 2007 | 17687013 |
| sporotrichosis in an hiv-positive man with oral lesions: a case report. | sporotrichosis is a granulomatous fungal infection caused by sporothrix schenckii, which frequently causes cutaneous or lymphocutaneous lesions and rarely has oral manifestations. | 2007 | 17718145 |
| tgf-beta1 induces transendothelial migration of the pathogenic fungus sporothrix schenckii by a paracellular route involving extracellular matrix proteins. | sporotrichosis, a mycosis caused by sporothrix schenckii, is characterized by lymphocutaneous lesions. in immunocompromised hosts, this fungus may invade the bloodstream and disseminate to other tissues, such as lung and bone. our group previously showed that s. schenckii yeasts adhere to endothelial monolayers and that this interaction is modulated by cytokines. using 3.0 mum-pore culture inserts, the present work shows that transforming growth factor (tgf)-beta1 led to a 80+/-26 % increase in ... | 2007 | 17768235 |
| sporotrichosis in childhood: clinical and therapeutic experience in 25 patients. | sporotrichosis in an uncommon mycoses in childhood and is generally associated with injuries received as a consequence of farm work. we undertook a retrospective study of sporotrichosis in children and adolescents seen over a 10-year period, focusing on their clinical, epidemiologic, and mycologic features as well as treatment. we included 25 children with a mean age of 9.3 years. most of those affected were schoolchildren (84%) from rural areas. the main clinical variety of sporotrichosis seen ... | 2007 | 17845157 |
| evaluation of cats as the source of endemic sporotrichosis in peru. | although contact with domestic cats has been shown to be a risk factor for sporotrichosis in endemic areas, systematic evaluation of apparently unaffected cats as possible reservoirs for infection has not been explored. the goals of this study were to identify the following aspects of sporotrichosis in the endemic area of abancay, peru: (i) the overall prevalence of sporotrichosis in the cat population, (ii) the most common site where the fungus can be isolated from these cats, and (iii) whether ... | 2008 | 17885948 |
| comparison of virulence of different sporothrix schenckii clinical isolates using experimental murine model. | the virulence of two strains of sporothrix schenckii isolated from patients with lymphocutaneous or disseminated sporotrichosis were examined in balb/c mice (group 1 and 2, respectively). the mice were inoculated subcutaneously into the left hind footpad with 4 x 10(6) s. schenckii yeast cells in order to evaluate (i) the development of cutaneous lesions, (ii) signs of inactivity, (iii) weight loss, (iv) survival rates, (v) number of viable yeast cells in the lungs and spleen, (vi) splenic index ... | 2007 | 17885952 |
| isolation of sporothrix schenckii from the environmental sources of cutaneous sporotrichosis patients in himachal pradesh, india: results of a pilot study. | himachal pradesh, india is a known endemic area for cutaneous sporotrichosis. no attempt has been made to isolate sporothrix schenckii, the causative fungus, from environmental sources in this region or in india as such. this prospective study was carried out to isolate sporothrix schenckii from different environmental samples collected from the vicinity of cutaneous sporotrichosis patients. all patients of cutaneous sporotrichosis diagnosed during march 2005-february 2006 were studied. twenty-o ... | 2007 | 17944713 |
| outbreak of sporotrichosis, western australia. | a cluster of sporotrichosis cases occurred in the busselton-margaret river region of western australia from 2000 to 2003. epidemiologic investigation and mycologic culture for sporothrix schenckii implicated hay initially distributed through a commercial hay supplier as the source of the out-break. declining infection rates have occurred after various community measures were instigated. | 2007 | 17953099 |
| in vitro antifungal susceptibilities of five species of sporothrix. | ninety-two isolates belonging to five species of the sporothrix schenckii complex were tested in vitro against 12 antifungal agents, using a reference microdilution method. there were significant differences among the species; sporothrix brasiliensis was the species that showed the best response to antifungals, and s. mexicana had the worst response. in general, terbinafine was the most active drug, followed by ketoconazole and posaconazole. | 2008 | 18039919 |
| functional, genetic and bioinformatic characterization of a calcium/calmodulin kinase gene in sporothrix schenckii. | sporothrix schenckii is a pathogenic, dimorphic fungus, the etiological agent of sporotrichosis, a subcutaneous lymphatic mycosis. dimorphism in s. schenckii responds to second messengers such as camp and calcium, suggesting the possible involvement of a calcium/calmodulin kinase in its regulation. in this study we describe a novel calcium/calmodulin-dependent protein kinase gene in s. schenckii, sscmk1, and the effects of inhibitors of calmodulin and calcium/calmodulin kinases on the yeast to m ... | 2007 | 18047672 |
| a case of atypical sporotrichosis with multifocal cutaneous ulcers. | we report an atypical case of sporotrichosis in an elderly woman working as a horticulturist, who presented with multiple ulcers and nodules on the face and the right upper back. histological examination found numerous small yeast-like spores in the granulomatous reaction in the upper dermis. culture and dna analysis identified sporothrix schenckii, group b. misuse of topical steroids and self-inoculation may have caused the atypical features found in this patient. | 2008 | 18076693 |
| cutaneous sporotrichosis. intermittent treatment (pulses) with itraconazole. | sporotrichosis is a subcutaneous and exceptionally deep mycosis caused by a dimorphic fungus, sporothrix schenckii. itraconazole is a triazole derivative leading to good results in the treatment of sporotrichosis. patients with cutaneous sporotrichosis proven with mycological tests (direct examination and culture) were enrolled. all patients underwent laboratory tests (at baseline and on a monthly basis) and received oral itraconazole 400 mg/day for one week with a 3-week break (pulses); thereaf ... | 2008 | 18086591 |
| coccidioidomycosis and other endemic mycoses in mexico. | the endemic mycoses traditionally include coccidioidomycosis, histoplasmosis, blastomycosis and paracoccidioidomycosis. although sporotrichosis and chromomycosis are technically not included among the endemic mycoses, they are frequently diagnosed in mexico. most systemic endemic mycoses are a consequence of inhaling the fungi, while subcutaneous mycoses are acquired through the inoculation of vegetable matter or soil containing the organism. coccidioidomycosis is caused by coccidioides spp., a ... | 2007 | 18095755 |
| [isolation of sporothrix schenckii from environmental samples in venezuela]. | the dimorphic fungus sporothrix schenckii is the etiological agent of sporotrichosis, a subcutaneous mycosis frequently found in latin america. the isolation of this fungus from the environment and other sources has been widely reported. nevertheless, to our knowledge this fungus has not been isolated from the endemic areas of venezuela. in studies related to a clinical case of sporotrichosis in "colonia tovar", produced by traumatism after manipulating soil samples, the fungus was isolated from ... | 2007 | 18095768 |
| detrimental role of endogenous nitric oxide in host defence against sporothrix schenckii. | we earlier demonstrated that nitric oxide (no) is a fungicidal molecule against sporothrix schenckii in vitro. in the present study we used mice deficient in inducible nitric oxide synthase (inos-/-) and c57bl/6 wild-type (wt) mice treated with nomega-nitro-arginine (nitro-arg-treated mice), an nos inhibitor, both defective in the production of reactive nitrogen intermediates, to investigate the role of endogenous no during systemic sporotrichosis. when inoculated with yeast cells of s. schencki ... | 2008 | 18194265 |
| fine-needle aspiration biopsy of disseminated sporotrichosis: a case report. | in this report, we describe a case of disseminated sporotrichosis that was diagnosed by fine-needle aspiration biopsy (fnab). the cytologic smears exhibited a large number of macrophages, few polymorphonuclear neutrophils and numerous round or oval, sometimes elongated, isolated and scattered yeast-like structures localized extracellularly or inside macrophages. these structures were clearly visualized by giemsa and papanicolaou methods. cultures from skin biopsy material revealed fungal colonie ... | 2008 | 18231999 |
| endemic of zoonotic sporotrichosis: profile of cases in children. | sporotrichosis in childhood is rare in most countries. isolated cases and small outbreaks related to recreational activities or without identification of the transmission mechanism have been reported. | 2008 | 18277928 |
| outbreaks of sporotrichosis. | this article examines the reasons for clusters of cases or outbreaks of sporotrichosis such as the brazilian outbreak described in this issue of current opinion in infectious diseases. it highlights areas that require elucidation such as the infectivity of yeast phase fungi in relation to other outbreaks. it then describes phenotypic variations seen with sporothrix schenckii that could contribute to pathogenesis and enhanced infectivity of fungi in the environment. | 2008 | 18317032 |
| epidemic sporotrichosis. | epidemic sporotrichosis is rare and has been related to an environmental source of infection. there were no reports of epizootics before a cat-transmitted epidemic was reported in rio de janeiro, brazil. in the present paper we review the data published on this epidemic. | 2008 | 18317034 |
| molecular epidemiology and antifungal susceptibility patterns of sporothrix schenckii isolates from a cat-transmitted epidemic of sporotrichosis in rio de janeiro, brazil. | since 1998 a cat-transmitted epidemic of sporotrichosis has been observed in rio de janeiro (rj), brazil. besides the lymphocutaneous and fixed forms, other presentations, such as disseminated cutaneous and mucosal involvement, as well as for the first time, erythema nodosum and erythema multiforme have been reported associated with sporotrichosis. this study investigates the phenotypes and genotypes of sporothrix schenckii isolates recovered from different clinical forms of the disease noted as ... | 2008 | 18324493 |
| vesicular transport in histoplasma capsulatum: an effective mechanism for trans-cell wall transfer of proteins and lipids in ascomycetes. | vesicular secretion of macromolecules has recently been described in the basidiomycete cryptococcus neoformans, raising the question as to whether ascomycetes similarly utilize vesicles for transport. in the present study, we examine whether the clinically important ascomycete histoplasma capsulatum produce vesicles and utilized these structures to secrete macromolecules. transmission electron microscopy (tem) shows transcellular secretion of vesicles by yeast cells. proteomic and lipidomic anal ... | 2008 | 18419773 |
| lymphocutaneous sporotrichosis in an immunocompetent patient: a case report from extreme southern italy. | sporotrichosis is a mycotic infection rarely encountered in european countries, including italy. we describe lymphocutaneous sporotrichosis in an immunocompetent 64-year-old male italian mason. the patient had linear nodules along the right upper arm with severe lymphadenopathy in the same arm. sporothrix schenckii was identified by phenotypic and molecular methods. treatment with itraconazole and methylprednisolone followed by administration of itraconazole alone successfully cured the infectio ... | 2008 | 18421569 |
| spectral studies and bactericidal, fungicidal, insecticidal and parasitological activities of organotin(iv) complexes of thio schiff bases having no donor atoms. | twelve new organotin(iv) complexes of the type rnsnlm [where n = 3, m = 1, r = ch(3) or c(6)h(5); n = 2, m = 2, r = c(6)h(5) or c(4)h(9) ; l = anion of schiff bases derived from the condensation of 2-amino-5-(o-anisyl)-l,3,4-thiadiazole with salicylaldehyde (hl-1), 2- hydroxynaphthaldehyde (hl-2) and 2-hydroxyacetophenone (hl-3)] have been synthesized and characterized by elemental analysis, molar conductances, electronic, infrared, far-infrared, (1)h nmr and (119)sn mössbauer spectral studies. ... | 1995 | 18472781 |
| [in vitro comparison of antifungal activity of oxiconazole and econazole against yeast.]. | monoclonal antibodies (moabs) have had a major impact on many areas of biomedical research and almost since their advent have been used in the characterisation and identification of diagnostically important antigens of fungal pathogens. their main significance lies in three, often inter-related areas: a) the definition and characterisation of antigens for use in detection of antibody responses, b) their direct use in the detection of diagnostically useful antigen in body fluids c) their applicat ... | 1998 | 18473530 |
| [disseminated sporotrichosis - clinical case and discussion]. | the authors report a case of a patient with a prior history of alcohol abuse who developed nodules and ulcerated skin lesions on his trunk and lower extremities along the line of the lymphatic draining area. the patient's x-ray showed reticular nodular intersticial infiltrates at the lung bases. there was a positive culture of supraclavicular lymph node for sporothrix schenckii. after specific treatment using mainly potassium iodide, there was regression of cutaneous lesions and lung infiltrates ... | 2008 | 18528606 |
| isolation and some properties of a glycoprotein of 70 kda (gp70) from the cell wall of sporothrix schenckii involved in fungal adherence to dermal extracellular matrix. | sporothrix schenckii is the etiological agent of sporotrichosis, a subcutaneous mycosis and an emerging disease in immunocompromised patients. adherence to target cells is a prerequisite for fungal dissemination and systemic complications. however, information on the cell surface components involved in this interaction is rather scarce. in this investigation, the extraction of isolated cell walls from the yeast phase of s. schenckii with sds and separation of proteins by sds-page led to the iden ... | 2009 | 18608892 |
| asteroid body in sporotrichosis. yeast viability and biological significance within the host immune response. | the asteroid body in sporotrichosis (ab) is a characteristic structure that allows diagnosis in lymphangitic presentations and whose generation and composition is not fully understood. our study focused on the biological relationship between the yeast and host elements present in the ab. indirect immunofluorescence showed that on abs obtained from naturally infected individuals there were antigenically related igg and igm molecules in the spikes of the radiated crowns. however, there were differ ... | 2008 | 18608903 |
| nodular lymphangitis: a distinctive clinical entity with finite etiologies. | nodular lymphangitis, characterized by inflammatory nodules along the lymphatics draining a primary skin infection, most commonly follows superficial inoculation with sporothrix schenckii, nocardia brasiliensis, mycobacterium marinum, leishmania (viannia) panamensis/guyanensis, and francisella tularensis. epidemiologic context, clinical presentation, and presumed incubation period help to predict the specific etiologic microorganism. sporotrichosis, often occurring in gardeners, remains the most ... | 2008 | 18687205 |
| 2,3-disubstituted-1,4-naphthoquinones, 12h-benzo[b]phenothiazine-6,11-diones and related compounds: synthesis and biological evaluation as potential antiproliferative and antifungal agents. | a series of 2-chloro-3-arylsulfanyl-[1,4]naphthoquinones (2), 2,3-bis-arylsulfanyl-[1,4]naphthoquinones (3) and 12h-benzo[b]phenothiazine-6,11-diones and their analogs 6-8 were synthesized and evaluated for their antiproliferative activity against human cervical cancer (hela) cells. compounds 3a and 3b were found to possess most potent antiproliferative and cell killing ability. compounds 1-8 were also evaluated for antifungal activities. the structure-activity relationship of these compounds wa ... | 2009 | 18708272 |
| in vitro interactions of itraconazole and micafungin against clinically important filamentous fungi. | the in vitro interactions between itraconazole and micafungin against 133 strains of filamentous fungi of clinical interest were evaluated using a checkerboard method. overall, synergistic interactions were observed against 30% of the strains tested. in the cases of aspergillus fumigatus, aspergillus flavus, aspergillus terreus, fonsecaea spp. and sporothrix schenckii, synergistic interactions were observed against > or = 50% of the strains tested. for the rest of the fungi the interaction was i ... | 2008 | 18762407 |
| melanin as a virulence factor of paracoccidioides brasiliensis and other dimorphic pathogenic fungi: a minireview. | melanin pigments are substances produced by a broad variety of pathogenic microorganisms, including bacteria, fungi, and helminths. microbes predominantly produce melanin pigment via tyrosinases, laccases, catecholases, and the polyketide synthase pathway. in fungi, melanin is deposited in the cell wall and cytoplasm, and melanin particles ("ghosts") can be isolated from these fungi that have the same size and shape of the original cells. melanin has been reported in several human pathogenic dim ... | 2008 | 18777637 |
| biological activity of two related triterpenes isolated from combretum nelsonii (combretaceae) leaves. | antifungal bioassay-guided fractionation of combretum nelsonii leaf extracts afforded two closely related triterpenes, asiatic acid and arjunolic acid. antifungal activities of the mixture of asiatic acid and arjunolic acid were determined against five fungal animal pathogens. the minimum inhibitory concentrations of the mixture to the different pathogens varied from 0.2 to 1.6 microg ml(-1); candida albicans (0.9 microg ml(-1)), cryptococcus neoformans (0.4 microg ml(-1)), aspergillus fumigatus ... | 2008 | 18780249 |
| stable yeast-like form of sporothrix schenckii: lack of dimorphic stage. | | 2008 | 18799707 |
| brazilian propolis: correlation between chemical composition and antimicrobial activity. | the chemical composition of ethanol extracts from samples of brazilian propolis (eeps) determined by hplc and their activity against trypanosoma cruzi, staphylococcus aureus, streptococcus pneumoniae, klebisiella pneumoniae, candida albicans, sporothrix schenckii and paracoccidioides brasiliensis were determined. based on the predominant botanical origin in the region of samples' collection, the 10 extracts were separated into three groups: a (b. dracunculifolia + auraucaria spp), b (b. dracuncu ... | 2008 | 18830454 |
| taxonomy and phylogeny of new wood- and soil-inhabiting sporothrix species in the ophiostoma stenoceras-sporothrix schenckii complex. | sporothrix, one of the anamorph genera of ophiostoma, includes the important human pathogen s. schenckii and various fungi associated with insects and sap stain of wood. a survey of fungi from wood utility poles in south africa yielded two distinct groups of sporothrix isolates from different geographical areas. dna sequence and morphological data derived in this study showed that isolates in these groups represent two novel species in the s. schenckii-o. stenoceras species complex. a new specie ... | 2008 | 18833758 |
| passive immunization with monoclonal antibody against a 70-kda putative adhesin of sporothrix schenckii induces protection in murine sporotrichosis. | cell-mediated and innate immunity are considered the most important mechanisms of host defense against fungus infections. however, recent studies demonstrated that specific antibodies show different degrees of protection against mycosis. in a previous study, antigens secreted by sporothrix schenckii induced a specific humoral response in infected animals, mainly against the 70-kda molecule, indicating a possible participation of antibodies to this antigen in infection control. in the present stu ... | 2008 | 18991286 |
| antifungal activities of compounds isolated from piper abutiloides kunth. | piperaceae is a family of tropical plants known to have antifungal, antibacterial, tumour-inhibitory, antiviral, antioxidant, molluscicidal and leishmanicidal activities. in this work, extracts and fractions from aerial parts of piper abutiloides (piperaceae), a traditional medicinal plant, were evaluated against the fungal species candida albicans, c. parapsilosis, c. krusei, c. glabrata, c. tropicalis, cryptococcus neoformans and sporothrix schenckii. the results have shown that the antifungal ... | 2009 | 19076283 |
| polyarticular sporothrix schenckii infection in an immunocompetent host. | septic arthritis is an unusual complication of sporothrix schenckii infection. its diagnosis can be very difficult, mainly because of low clinical suspicion, special media needed for its culture, and low density of the organism in biopsy specimens. we present a case of a woman with disseminated sporothrix schenckii infection and polyarthritis. although rare, this wide dissemination of fungus and polyarthritis occurred in an initially immunocompetent patient. steroid therapy given for suspected v ... | 1996 | 19078068 |
| differential mrna expression of sporothrix schenckii catalase gene in two growth phases and effect factors. | | 2008 | 19080283 |
| sporothrix luriei: a rare fungus from clinical origin. | sporothrix schenckii var. luriei is a very rare pathogen reported on four occasions from human infections, but only isolated from one case in africa. here, it is proposed as a species different from sporothrix schenckii on the basis of phenotypic characteristics and a multilocus sequence analysis. | 2008 | 19180753 |
| heterogeneity of proteins expressed by brazilian sporothrix schenckii isolates. | the profiles of proteins present in the exoantigens of brazilian sporothrix schenckii isolates were studied and compared by electrophoresis (sds-page). thirteen isolates from five different regions of brazil (1,000 to 2,000 km apart) and ten from a more limited region (200 to 400 km apart within the state of são paulo) were cultured in sabouraud, m199 and minimum (mm) media. qualitative and quantitative differences in the expression of proteins, which varied according to the medium and the isola ... | 2009 | 19184772 |
| mitochondrial dna analysis of sporothrix schenckii in india, thailand, brazil, colombia, guatemala and mexico. | up to now, 30 mitochondrial dna(mtdna)and 4 rdna types of sporothrix schenckii strains have been identified. here, seventy-six isolates of s. schenckii from mexico, guatemala, brazil, thailand and india were genotyped and studied epidemiologically by mtdna restriction fragment length polymorphisms(rflp)and internal transcribed spacer region(its)-rflp analysis and two new mtdna types, type 31 and type 32, were found. type 30, previously reported by mora-cabrera et al. was confirmed to be type 3 a ... | 2009 | 19194056 |
| a comparative serological study of the sscbf antigenic fraction isolated from three sporothrix schenckii strains. | a previous work showed that an antigenic fraction of sporothrix schenckii, sscbf, was specifically recognized by igg antibodies present in patients' clinical specimens. the objective of this investigation was to compare the reactivity of this antigen recovered from three s. schenckii strains. roc curve analysis revealed a variation in the sensitivity and specificity of the antigen derived from each of the strains, with a higher auc for strain 1099-18. moreover, the presence of the main o-glycosi ... | 2009 | 19194817 |
| arthritis as a hypersensitivity reaction in a case of sporotrichosis transmitted by a sick cat: clinical and serological follow up of 13 months. | sporotrichosis is a subacute or chronic fungal infection caused by sporothrix schenckii, which is commonly acquired by traumatic inoculation of the fungus carried in a contaminated material into the skin. joint involvement is the most frequent extracutaneous manifestation in immunosuppressed patients. we report the case of an immunocompetent woman who acquired sporotrichosis through the scratch of a sick cat. she presented skin lesions and arthritis possibly because of a hypersensitivity reactio ... | 2010 | 19207845 |
| fatal ophiostoma piceae infection in a patient with acute lymphoblastic leukaemia. | we report to our knowledge the first case of human infection with ophiostoma piceae. this sporothrix schenckii-related fungus caused disseminated infection involving the lung and the brain in a patient with lymphoblastic lymphoma. the case emphasizes the significance of molecular techniques for identification of rare fungi in the clinical microbiology laboratory. | 2009 | 19208892 |
| excretion-secretion products and proteases from live sporothrix schenckii yeast phase: immunological detection and cleavage of human igg. | antigenic preparations from sporothrix schenckii usually involve materials from mixed cultures of yeast and mycelia presenting cross-reactions with other deep mycoses. we have standardized pure yeast phase with high viability of the cells suitable to obtain specific excretion-secretion products without somatic contaminations. these excretion-secretion products were highly immunogenic and did not produce noticeable cross-reactions in either double immunodiffusion or western blot. the antigenic pr ... | 2009 | 19229383 |
| current research on the immune response to experimental sporotrichosis. | sporotrichosis is often manifested as a chronic granulomatous infection and the monocytes/macrophages play a central role in the host defense system. surface components of sporothrix schenckii have been characterized and suggestions have been made as to their possible role in pathogenicity. ergosterol peroxide, cell-wall compounds (alkali-insoluble fraction-f1 and lipid extract-ley), and exoantigen from the yeast form of the fungus have been characterized as virulence factors, activating both in ... | 2009 | 19241140 |
| fixed sporotrichosis as a cause of a chronic ulcer on the knee. | chronic wounds are a major health care problem worldwide. wound healing is a holistic endeavour that requires an accurate identification of the specific entities interfering with wound healing in a particular patient. we present a case of fixed sporotrichosis as the cause of a chronic ulcer in the knee. although a culture of sporothrix schenckii could not be obtained, a positive response to the sporotrichin skin test, a skin biopsy showed a suppurative granuloma and an adequate response to oral ... | 2009 | 19291118 |
| [autochthonous cutaneous sporotrichosis in france]. | sporotrichosis is rare in europe. we report a case of fixed cutaneous sporotrichosis in an immunocompetent french patient. | 2009 | 19328312 |
| growth conditions influence melanization of brazilian clinical sporothrix schenckii isolates. | sporothrix schenckii is known to produce dhn melanin on both conidial and yeast cells, however little information is available regarding the factors inducing fungal melanization. we evaluated whether culture conditions influenced melanization of 25 brazilian s. schenckii strains and one control strain (atcc 10212). tested conditions included different media, ph, temperature, incubation time, glucose concentrations, and presence or absence of tricyclazole or l-dopa. melanization was reduced on sa ... | 2009 | 19328867 |
| design, synthesis and biological evaluation of novel nitrogen and sulfur containing hetero-1,4-naphthoquinones as potent antifungal and antibacterial agents. | a series of 2-arylamino-3-chloro-1,4-naphthoquinones (3), 2-amino-3-arylsulfanyl-1,4-naphthoquinones (5), 2-arylamino-3-arylsulfanyl-1,4-naphthoquinones (6), dihydrobenzo[f]naphtho[2,3-b][1,4]thiazepine-6,11-diones (9) (via pictet-spengler cyclization), isoindoline-1,3-dione derivatives of 1,4-naphthoquinone (13), 2,2'-(1,4-dioxo-1,4-dihydronaphthalene-2,3-diyl)bis(methylene)dibenzonitrile (14), 13-amino-12-substituted-6h-benzo[e]naphtho [2,3-b][1,4]diazepine-6,11(12h)-diones (15-16), 2-chloro-3 ... | 2009 | 19349095 |
| sporothrix schenckii: purification and partial biochemical characterization of glucosamine-6-phosphate synthase, a potential antifungal target. | the first committed step of the biosynthetic pathway leading to uridine-5'-diphospho-n-acetyl-d-glucosamine (udp-glcnac) is catalyzed by glucosamine-6-phosphate synthase (glcn-6-p synthase), an enzyme proposed as a potential antifungal chemotherapy target. here, we describe the purification and biochemical characterization of the native enzyme from the dimorphic pathogenic fungus sporothrix schenckii. the availability of the pure protein facilitated its biochemical characterization. the enzyme e ... | 2010 | 19353425 |
| histopathology of canine sporotrichosis: a morphological study of 86 cases from rio de janeiro (2001-2007). | the present study reports the histopathological findings of 86 skin lesions of dogs with sporotrichosis from rio de janeiro. suppurative granulomatous inflammation was the predominant finding and was observed in 76 (88.37%) cases. plasma cells surrounding the suppurative granulomas were detected in 68 (89.5%) cases and an inflammatory infiltrate at the periphery of these granulomatous lesions was observed in 63 (82.9%). fungus-specific staining revealed yeast cells compatible with sporothrix sch ... | 2009 | 19360480 |
| antifungal susceptibility profile in vitro of sporothrix schenckii in two growth phases and by two methods: microdilution and e-test. | the susceptibility profile of 91 sporothrix schenckii isolates in both growth phases was determined by microdilution test (antifungal susceptibility testing of the european committee for antimicrobial susceptibility testing; afst-eucast). amphotericin b (amb), itraconazole (itc), posaconazole, ravuconazole and terbinafine were found active in vitro against both phases but minimum inhibitory concentrations values for mycelial phase were significantly higher. fluconazole (flc) and voriconazole (vr ... | 2010 | 19389067 |
| antimicrobial evaluation of clerodane diterpenes from polyalthia longifolia var. pendula. | phytochemical investigation of the ethanolic extract of leaves of polyalthia longifolia var. pendula has led to the isolation of seven clerodane diterpenoids and five alkaloids. (-)-14, 15-bisnor-3, 11e-kolavadien-13-one (1), (-)-16-oxocleroda-3,13(14)e-dien-15-oic acid (2), (-)-16alpha-hydroxycleroda-3,13 (14)z-dien-15,16-olide (3), (+)-(4-->2)-abeo-16(r/s)-2, 13z-kolavadien-15, 16-olide-3-al (4), (-)-3beta, 16beta-dihydroxycleroda-4(18), 13(14)z-dien-15,16-olide (5), (-)-3, 12e-kolavadien-15-o ... | 2009 | 19413108 |
| cytosolic phospholipase a2: a member of the signalling pathway of a new g protein alpha subunit in sporothrix schenckii. | sporothrix schenckii is a pathogenic dimorphic fungus, the etiological agent of sporotrichosis, a lymphocutaneous disease that can remain localized or can disseminate, involving joints, lungs, and the central nervous system. pathogenic fungi use signal transduction pathways to rapidly adapt to changing environmental conditions and s. schenckii is no exception. s. schenckii yeast cells, either proliferate (yeast cell cycle) or engage in a developmental program that includes proliferation accompan ... | 2009 | 19454031 |
| different virulence levels of the species of sporothrix in a murine model. | a comparative study on the experimental pathogenicity of five species of sporothrix of clinical interest, sporothrix albicans, sporothrix brasiliensis, sporothrix globosa, sporothrix mexicana, and sporothrix schenckii sensu stricto, was performed using an immunocompetent murine model. two strains of each species and two levels of inoculum for each strain (2x10(7) and 2x10(4) conidia/animal) were tested by intravenous inoculation of mice (ten per group). mortality was caused by the low inoculum o ... | 2009 | 19624508 |
| identification of sporothix schenckii of various mtdna types by nested pcr assay. | we employed a nested pcr assay to detect sporothrix schenckii dna of 38 strains (including all the 24 mtdna types) collected from different areas of the world, in tissue of eight mice infected with atcc10268 strain of the fungus, and the skin biopsies of nine patients with sporotrichosis. in addition, the same procedures were used with two strains of ceratocystis minor and isolates of 10 species of other pathogenic fungi. the outer primers ss(1) and ss(2) and inner primers ss(3) and ss(4) of the ... | 2010 | 19626548 |
| sporothrix globosa, a pathogenic fungus with widespread geographical distribution. | sporothrix globosa, reported from the usa, europe, and asia, is a recently described pathogenic species morphologically similar to sporothrix schenckii. in this study, the phylogenetic affinities of 32 clinical and environmental isolates morphologically identified as s. schenckii, from mexico, guatemala, and colombia, were assessed by cladistic analysis of partial sequences of the calmodulin gene using the maximum parsimony and neighbor-joining methods. the study revealed that one out of 25 isol ... | 2009 | 19635441 |
| sporotrichosis: a retrospective evaluation of 23 cases seen in northern california (1987-2007). | sporotrichosis is an uncommon to rare cutaneous and subcutaneous mycosis of animals and humans caused by the dimorphic fungus sporothrix schenckii. twenty-three mammalian cases of sporotrichosis examined between 1987 and 2007 at the university of california, davis - veterinary medical teaching hospital, were retrospectively evaluated with regard to the historical, clinical, diagnostic and treatment findings. cats were the most common species affected (n = 14). in addition, sporotrichosis was dia ... | 2009 | 19659536 |
| mics and minimum fungicidal concentrations of amphotericin b, itraconazole, posaconazole and terbinafine in sporothrix schenckii. | the in vitro susceptibility of 62 isolates of sporothrix schenckii in its mycelial form, from latin-american countries (peru, venezuela, brazil and uruguay) and spain, to amphotericin b (ab), itraconazole (iz), posaconazole (pz) and terbinafine (tb) was determined by measuring the mics and minimum fungicidal concentrations (mfcs) using a standardized clinical and laboratory standards institute method. in general, tb was the most active drug, with the lowest geometric mean (gm) mic and mfc values ... | 2009 | 19679687 |
| spontaneous resolution of zoonotic sporotrichosis during pregnancy. | sporotrichosis is the most common deep mycosis in latin america. the zoonotic transmission from cats has been demonstrated over the last few decades in many countries. a forty year-old veterinarian examined a cat with multiple ulcerations, which mycological examination isolated sporothrix schenckii. during the examination, she was bitten in the right index finger by the animal. two weeks later, an inflammatory lesion appeared, which became ulcerated and was followed by ascendant lymphangitis. th ... | 2009 | 19739007 |
| response of macrophage toll-like receptor 4 to a sporothrix schenckii lipid extract during experimental sporotrichosis. | toll-like receptors have been implicated in the recognition of various pathogens, including bacteria, viruses, protozoa and fungi. however, no information is available about toll-like receptor 4 (tlr4) participation in sporothrix schenckii recognition and the consequent triggering of the immune response to this fungal pathogen. following activation of tlrs by ligands of microbial origin, several responses are provoked, including reactions in immune cells that may lead them to produce signalling ... | 2009 | 19740386 |
| cell surface expression of adhesins for fibronectin correlates with virulence in sporothrix schenckii. | the virulence of four sporothrix schenckii isolates was compared in a murine model of sporotrichosis, together with the protein pattern of the yeast cell surface and the capacity to bind the extracellular matrix protein fibronectin. virulence was determined by the mortality rate, fungal burden and histopathology. two clinical isolates were more virulent for c57bl/6 mice, but no direct correlation was seen between virulence and the clinical or environmental origin of the isolates. the lowest viru ... | 2009 | 19762444 |
| [simultaneous bilateral lymphangitic sporotrichosis]. | sporotrichosis is the most frequent subcutaneous mycoses in jalisco, mexico. the forms of transmission described in the literature are from bites of different animals and injuries due to utensils. | 2009 | 19818662 |
| molecular characterisation of sporothrix schenckii isolates from humans and cats involved in the sporotrichosis epidemic in rio de janeiro, brazil. | an epidemic of sporotrichosis, a subcutaneous mycosis caused by the fungus sporothrix schenckii, is ongoing in rio de janeiro, brazil, in which cases of human infection are related to exposure to cats. in an attempt to demonstrate the zoonotic character of this epidemic using molecular methodology, we characterised by dna-based typing methods 19 human and 25 animal s. schenckii isolates from the epidemic, as well as two control strains. to analyse the isolates, the random amplified polymorphic d ... | 2009 | 19820840 |
| oral potassium iodide for the treatment of sporotrichosis. | sporotrichosis is a subacute or chronic disease, usually affecting the skin caused by a dimorphic (existing in two forms), aerobic (oxygen requiring) fungus called sporothrix schenckii. oral potassium iodide is widely used for cutaneous sporotrichosis in clinical medicine with more and more reports published. however, the benefits and adverse reactions of these treatments have not yet been systematically reviewed. | 2009 | 19821356 |
| neonatal sporotrichosis. | sporotrichosis is caused by the dimorphic fungus, sporothrix schenckii. classically, infection occurs after implantation of the organism into the skin by abrasion of a puncture wound by contaminated thorns, hay, or sphagnum moss. cats are also a commonly recognized source of sporotrichosis. in children, fixed cutaneous lesions are more common than lymphocutaneous lesions, and the face is a frequent location for infection. we present a neonate with a fixed cutaneous facial lesion and both pre-aur ... | 2009 | 19840311 |
| refractory subcutaneous abscesses caused by sporothrix schenckii. a new pathogenic fungus. | | 1900 | 19866937 |
| role of melanin in the pathogenesis of cutaneous sporotrichosis. | in this study, we evaluate the clinical, histopathological and ultra structural aspects of the infection by field strain (mel(+)) and mutated strain (mel(-)) of sporothrix schenckii. the development of sporotrichosis at the inoculation sites was similar for both groups of animals after the second week of the experimental period. statistical differences appeared only at weeks 3 and 5. the pigmented isolate had greater tissue invasive capacity, promoting the formation of multifocal granulomas, whe ... | 2010 | 19883789 |
| fixed cutaneous sporotrichosis. | sporotrichosis is a subcutaneous mycosis that is caused by sporothrix schenckii. whereas the most common clinical presentation is the lymphocutaneous form, the fixed cutaneous form is not uncommon. important clues from the clinical history, such as travel and occupation, can help to raise the suspicion of this infection in the differential diagnosis. however, histopathologic and tissue culture, which often require multiple specimens, are necessary to confirm the diagnosis. we present a patient w ... | 2009 | 19891913 |
| [sporotrichosis and dematiaceous fungal skin infections]. | sporotrichosis is a chronic infectious granuloma of skin. the detection of fungal elements in pathological examination and the isolation of sporothrix schenckii from the lesion are requisite for diagnosis. the sporotrichin test is useful as an auxiliary examination, but a false-negative reaction might occur in some cases. oral potassium iodide is first choice of treatment, because of its modest cost and usefulness, although gastrointestinal disorder is a frequent side effect. itraconazole should ... | 2009 | 19942791 |
| zoonotic sporotrichosis of lymphocutaneous type in a man acquired from a domesticated feline source: report of a first case in southern karnataka, india. | sporotrichosis is commonly encountered due to traumatic implantation of thorns or decayed vegetation with the dimorphic fungi, sporothrix schenckii. zoonotic spread of sporotrichosis is rare and we describe here the first case of feline transmission of lymphocutaneous sporotrichiosis encountered in india. | 2009 | 20064175 |
| ribosomal dna sequencing and phylogenetic analysis of environmental sporothrix schenckii strains: comparison with clinical isolates. | the authors reported the isolation and genetic characterization of sporothrix schenckii strains from natural environmental samples and commercial amended and garden soils. twenty-six isolates were recovered and identified as s. schenckii by using both phenotypic and molecular methods. the majority of the strains were isolated from commercial amended and garden soils, indicating that these products represent an important reservoir of the fungus. sequencing and phylogenetic analysis of the d1-d2 r ... | 2010 | 20119849 |
| effect of anti-glycosphingolipid monoclonal antibodies in pathogenic fungal growth and differentiation. characterization of monoclonal antibody mest-3 directed to manpalpha1-->3manpalpha1-->2ipc. | studies carried out during the 1990's demonstrated the presence of fungal glycoinositol phosphorylceramides (gipcs) with unique structures, some of them showed reactivity with sera of patients with histoplasmosis, paracoccidioidomycosis or aspergillosis. it was also observed that fungal gipcs were able to inhibit t lymphocyte proliferation "in vitro", and studies regarding the importance of these molecules to fungal survival showed that many species of fungi are vulnerable to inhibitors of sphin ... | 2010 | 20156351 |
| purification and biochemical characterisation of endoplasmic reticulum alpha1,2-mannosidase from sporothrix schenckiil. | alpha 1,2-mannosidases from glycosyl hydrolase family 47 participate in n-glycan biosynthesis. in filamentous fungi and mammalian cells, alpha1,2-mannosidases are present in the endoplasmic reticulum (er) and golgi complex and are required to generate complex n-glycans. however, lower eukaryotes such saccharomyces cerevisiae contain only one alpha1,2-mannosidase in the lumen of the er and synthesise high-mannose n-glycans. little is known about the n-glycan structure and the enzyme machinery inv ... | 2010 | 20209334 |
| [experimental cutaneous sporotrichosis: in vivo evaluation of itraconazole and terbinafine]. | the aim of this study was to evaluate the in vivo activity of itraconazole and terbinafine for treating experimental cutaneous sporotrichosis. eighty wistar rats were used, divided into four groups (terb20, terb30, itra and cont). they were inoculated in the left plantar pad with 0.2 ml of solution containing 2x10(3) cell/ml of sporothrix schenckii and treated with terbinafine (20 and 30 mg/kg), itraconazole (10 mg/kg) or placebo for 13 weeks. the lesions at the inoculation site were evaluated a ... | 2009 | 20209359 |
| [sporothrix schenckii infection in a cat]. | a four-year-old male castrated domestic shorthair cat imported from north america was presented due to a chronic parapreputial wound. cytological and mycological examination revealed a sporotrichosis. sporothrix schenckii lives as a saprophyte in the soil and can cause a subcutaneous and systemic mycosis in cats.the disease has been reported in tropical and subtropical areas. clinical signs, diagnostics, as well as therapy and course of the disease are described. treatment with itraconazole was ... | 2010 | 20329645 |
| [sporotrichosis: prevalence, clinical and epidemiological features in a reference center in colombia]. | sporotrichosis is a subacute and chronic infection caused by sporothrix schenckii, which affects humans and other mammals. clinical and epidemiological information in colombia is scarce. | 2010 | 20346295 |
| l-dopa accessibility in culture medium increases melanin expression and virulence of sporothrix schenckii yeast cells. | melanin is a complex polymer widely distributed in nature and has been described as an important virulence factor in several pathogenic fungi, including sporothrix schenckii. the aim of the present work was to investigate the presence of melanin on the surface of s. schenckii yeast cells which showed differences in their virulence depending on the culture conditions under which they were grown. yeast cells were cultivated in brain heart infusion (bhi) broth from difco and oxoid. bhi from these t ... | 2010 | 20392149 |
| sporothrix schenckii meningitis in aids during immune reconstitution syndrome. | sporotrichosis is a fungal disease usually restricted to the cutaneous and lymphatic systems. visceral involvement is unusual. to date, only 21 cases of sporotrichosis meningitis have been reported, some of these associated with immunosuppression. according to the reported cases, difficulty establishing the correct diagnosis is almost the rule which, undoubtedly, is associated with a worse prognosis. in this report, two hiv infected patients are described who developed meningitis due to sporothr ... | 2010 | 20392979 |
| biological activity of the mite sancassania sp. (acari: acaridae) from bat guano associated with the pathogenic fungus histoplasma capsulatum. | mites and the mammal pathogenic fungus histoplasma capsulatum are the major components of bat guano microbiota. interactions between mites and h. capsulatum were evaluated under laboratory conditions. acarid mites, mainly sancassania sp., were the most abundant microarthropod in the sampled guano of the mexican bat tadarida brasiliensis mexicana and, based on its morphology, sancassania sp. was similar to the cosmopolitan species sancassania sphaerogaster. the mycophagous and vectoring activitie ... | 2010 | 20428669 |
| sporotrichosis atypical presentation as a soft tissue tumour. | sporotrichosis is a mycosis caused by a saprophytic dimorphic fungus named sporothrix schenckii. infections occur following traumatic inoculation of fungus from plants and infected cat bites and scratches. we report a case of a farmer who presented with a solitary subcutaneous nodule initially diagnosed as a soft tissue tumour. a history of agricultural activity and feline contact should draw the clinician's attention to sporotrichosis, as the diagnosis can be easily missed in atypical cases. th ... | 2009 | 20514859 |
| subcutaneous nodules and infectious complications in renal allograft recipients. | renal transplant recipients are at increased risk of infectious diseases and subject to cutaneous infections because of the effects of immunosuppressive therapy. some long-term descriptive follow-up studies confirm that skin infections are common among renal transplant recipients. we report the development of subcutaneous nodules among patients receiving renal transplantations from 1991 to 2009. transplant recipients were followed by the nephrology unit at control visits according to the america ... | 2010 | 20534246 |
| cutaneous sporothrix schenckii of the human eyelid. | an 87-year-old patient presented with a 6-week history of an isolated progressive destructive nodular eyelid mass, secondary nodular and ulcerative lesions, and regional painful lymphadenopathy. after 4 weeks, fungal cultures demonstrated sporothrix schenckii. s. schenckii is a rare dimorphic fungus that can occasionally involve the periocular skin. the authors' case demonstrates typical clinical features, emphasizes the delay in diagnosis, and shows effective treatment with oral itraconazole. | 2010 | 20551856 |