| challenges facing child psychiatry in quebec at the dawn of the 21st century. | this study aimed to identify hospital resources by region, determine human resources by type of service and region, and describe how services generally operate in child psychiatry within the province of quebec. | 2005 | 15898459 |
| two mutations in the hsn2 gene explain the high prevalence of hsan2 in french canadians. | hereditary sensory and autonomic neuropathy type 2 (hsan2; mim 201300) is a rare recessive neuropathy typically diagnosed in the first decade. the 1973 study of a french canadian family led to the definition of hsan2. | 2005 | 15911806 |
| disruption of an exon splicing enhancer in exon 3 of mlh1 is the cause of hnpcc in a quebec family. | a 3 bp deletion located at the 5' end of exon 3 of mlh1, resulting in deletion of exon 3 from rna, was recently identified. | 2006 | 15923275 |
| nramp1 is not associated with asthma, atopy, and serum immunoglobulin e levels in the french canadian population. | reduced infection by mycobacteria, including mycobacterium tuberculosis, may be partly responsible for increased prevalence of allergic and autoimmune diseases in developed countries. in a murine model of innate resistance to mycobacteria, the nramp1 gene has been shown to affect asthma susceptibility. from this observation, it was proposed that human nramp1 may be a modulator of asthma risk in human populations. to experimentally test the candidacy of nramp1 in asthma susceptibility, we charact ... | 2005 | 15988535 |
| adrenomyeloneuropathy: report of a new mutation in a french canadian female. | x-linked adrenoleukodystrophy is a peroxisomial disorder caused by mutations in the abcd1 gene. adrenomyeloneuropathy is the second most frequent phenotype (25-46%) of this disease and classically presents in adulthood with spastic paraparesis. female heterozygotes can be symptomatic, but they are frequently misdiagnosed as having multiple sclerosis. | 2005 | 16018167 |
| time-domain optical mammography softscan: initial results. | near-infrared (nir) technology appears promising as a noninvasive technique for breast cancer screening and diagnosis. the technology capitalizes on the relative transparency of human tissue in this spectral range and its sensitivity to the main components of the breast: water, lipid, and hemoglobin. in this study, the authors report quantitative measurements of these components and the functional contrast between healthy and diseased tissue. | 2005 | 16023382 |
| human metapneumovirus infection in adults with community-acquired pneumonia and exacerbation of chronic obstructive pulmonary disease. | we tested nasopharyngeal aspirate specimens by real-time polymerase chain reaction assays and paired serum samples by enzyme-linked immunosorbent assays. acute human metapneumovirus infections were identified in 6 (4.1%) of 145 adult patients who presented to the emergency department for pneumonia or acute exacerbation of chronic obstructive pulmonary disease during 2 winter/spring seasons in quebec, canada. | 2005 | 16028158 |
| a question of property rights in the human body. | | 1989 | 16086463 |
| effects of the peroxisome proliferator-activated receptor-gamma co-activator-1 gly482ser variant on features of the metabolic syndrome. | factors influencing the severity of the metabolic syndrome among obese subjects or the conversion to cardiovascular disease or type 2 diabetes (t2d) remain largely unknown, but there is strong evidence for genetic susceptibilities. peroxisome proliferator-activated receptor-gamma co-activator-1 (ppargc1) is a transcriptional co-activator of many nuclear receptors including ppar-gamma, involved in the regulation of fatty acid oxidation, skeletal muscle fiber type specificity, and gluconeogenesis. ... | 2005 | 16122961 |
| stin2 variant and family history of suicide as significant predictors of suicide completion in major depression. | suicide is the most serious outcome of major depression, yet not all depressed patients will commit suicide. genes, along with other factors, might account for this difference. serotonergic alterations have been observed in suicide and depression and impulsive-aggressive behaviors. therefore, we aimed to identify predictors of suicide, considering genetic variation at the serotonin transporter (5-htt) gene. | 2006 | 16125146 |
| a comparison of systemwide and hospital-specific performance measurement tools. | balanced scorecards are being implemented at the system and organizational levels to help managers link their organizational strategies with performance data to better manage their healthcare systems. prior to this study, hospitals in ontario, canada, received two editions of the system-level scorecard (sls)--a framework, based on the original balanced scorecard, that includes four quadrants: system integration and management innovation (learning and growth), clinical utilization and outcomes (i ... | 2005 | 16130808 |
| the douglas hospital longitudinal study of normal and pathological aging: summary of findings. | in 1988, our group initiated the douglas hospital longitudinal study of normal and pathological aging to assess the association between secretion of the stress hormone cortisol and cognitive performance in a group of 51 older adults. in this paper, we summarize the data obtained in this study to date. we have found that long-term exposure to high endogenous levels of cortisol is associated with both memory impairments and a 14; smaller volume of the hippocampus. we also report on studies showing ... | 2005 | 16151537 |
| comparison of the effects of four suicide prevention programs for family and friends of high-risk suicidal men who do not seek help themselves. | callers to a suicide prevention center concerned about high risk men were randomly invited to participate in one of four programs: information session, information session with telephone follow-up, rapid referral to mental health and abuse programs, or telephone support. comparison of pre-test, 2 month post-test and 6 months follow-up with 131 participants found that after third party participation, the third party participant reported that the suicidal men had significantly less suicidal ideati ... | 2005 | 16156493 |
| chromosome 11-q24 region in tourette syndrome: association and linkage disequilibrium study in the french canadian population. | previous studies have found association and linkage between tourette syndrome (ts) and markers at the 11q24 region, mainly with markers d11s1377 and d11s933. in order to determine if these positive findings could be replicated in our sample, we undertook a family-based association study in 199 french canadian ts nuclear families. we genotyped 572 individuals from 174 complete and 25 incomplete ts trios. tdt analysis failed to detect an association between ts and six markers from 11q24. furthermo ... | 2005 | 16158425 |
| detection of a major gene effect for ldl peak particle diameter and association with apolipoprotein h gene haplotype. | low-density lipoprotein (ldl) size, a coronary heart disease risk factor, is influenced by both genetic and environmental factors. results from the quebec family study (qfs) revealed that the ldl peak particle diameter (ldl-ppd) aggregates in families with a heritability coefficient above 50% and is affected by a major quantitative trait locus on chromosome 17q (lod=6.8). complex segregation analyses have consistently demonstrated a major gene effect influencing ldl size. in the present study, w ... | 2005 | 16159595 |
| hyped biomedical science or uncritical reporting? press coverage of genomics (1992-2001) in québec. | genomics integrates the promises and perils of modern biomedical science. canada and the province of québec embarked late but aggressively in genomics research based on the 'discourse of promise' in which genomics is embedded. this did not prevent the emergence of a 'discourse of concerns', and debates on the wider meaning of genomics and on the risks related to genomics applications such as gene therapy and gene testing. given this context, this study aims to understand the evolution of genomic ... | 2006 | 16174544 |
| cessation of injecting drug use among street-based youth. | young injecting drug users (idus) are at high risk for a number of negative health outcomes such as hepatitis b, hepatitis c, and human immunodeficiency virus (hiv) infection. however, very little is known about injecting drug-use patterns among this population, particularly with respect to cessation of injection. we sought to identify the factors associated with cessation of injection in a population of young street-based idus. a prospective cohort study design was used to assess long-term (> o ... | 2005 | 16195471 |
| impact of the chaouli decision. | | 2005 | 16197595 |
| use of a novel washing method combining multiple density gradients and trypsin for removing human immunodeficiency virus-1 and hepatitis c virus from semen. | to determine the effectiveness of a novel treatment designed to remove human immunodeficiency virus (hiv) -1 and hepatitis c virus (hcv) from spiked semen and to evaluate sperm motility and viability after treatment. | 2005 | 16213856 |
| genome-wide scan for linkage to obesity-associated hypertension in french canadians. | essential hypertension is a heterogeneous disorder that is thought to develop because of several overlapping subsets of underlying mechanisms. one such causal pathway may involve pathophysiological alterations induced by obesity. in the present study, we examined whether investigating clinically defined subtypes of hypertension, such as obesity-associated hypertension, facilitates the search for its genes. fifty-five extended families were selected on the basis of having > or =2 siblings affecte ... | 2005 | 16216983 |
| the montreal heart institute: the idea and the man behind it. | the montreal heart institute (mhi) opened on january 11, 1954. it was the work of a single individual, a young cardiologist with a vision. paul david (1919-1999) trained in the late 1940s -- first, in boston with paul dudley white and, second, in paris with jean lenègre, two of the well-known cardiologists of the times. in the early 1950s, the only heart institute in the world was the one that ignacio chavez had founded in mexico in 1944. montreal had a medical institute of its own, the montreal ... | 2005 | 16234880 |
| the history of cardiac catheterization. | the evolution of cardiac catheterization has occurred over at least four centuries. one of the first major steps was the description of the circulation of the blood by william harvey in 1628. the next milestone was the measurement of arterial pressure by stephen hales, one century later. however, the 19th century represented the golden age of cardiovascular physiology, highlighted by the achievements of carl ludwig, etienne-jules marey and claude bernard, among others. human cardiac catheterizat ... | 2005 | 16234881 |
| mc4r marker associated with stature in children and young adults: a longitudinal study. | we investigated the associations between a polymorphism in the melanocortin 4 receptor (mc4r) gene and changes in body size and composition from childhood to adulthood in the québec family study. ninety-one subjects (43 males) less than 18 years of age (mean age 13.5 +/- 2.4 years; range 8.4-17.8 years) at baseline were re-measured 11.2 years later on average. the anthropometric variables analyzed were height, weight, body mass index, percent body fat, sum of skinfolds, fat mass index, and fat f ... | 2005 | 16279363 |
| [recovery from persons living with schizophrenia]. | the study gives a theoretical explanation of how people living with schizophrenia recover. the 41-participant study (clients, family and health professional) was conducted using the grounded theory approach, in three different settings. based on analyses of the empirical data, the authors identified seven closely interrelated categories defining the participants' experiences and came up with a theory explaining how certain individuals manage to recover. their theory may guide researchers and cli ... | 2005 | 16329675 |
| [respiratory infection control]. | | 2005 | 16329677 |
| transmission of migration propensity increases genetic divergence between populations. | the advent of molecular genetics has brought invaluable information, which is now routinely used by anthropologists in their attempt to reconstruct our demographic past. since mitochondrial dna loci are much more similar between populations than are y-chromosome loci, it is suggested that women had a much higher migration rate than men throughout history. based on an examination of intergenerational migration patterns in three large demographic databases, we bring this inference into question. i ... | 2006 | 16342261 |
| sporadic infections of salmonella paratyphi b, var. java associated with fish tanks. | identify a source of contamination to explain the increase in the number of cases of s. paratyphi b var. java infection. | 2005 | 16350877 |
| an exploratory investigation of genetic linkage with body composition and fatness phenotypes: the québec family study. | in the present investigation, we have attempted to identify regions of the genome in which "obesity genes" potentially reside using robust sib-pair linkage analysis. data were collected on 1,628 individuals in 301 nuclear families residing in the environs of québec city during the period 1978-1981. in addition to traditional blood group antigens and enzyme polymorphisms, several phenotypes in the obesity domain that are associated with increased morbidity were assessed, including measures relati ... | 1994 | 16355479 |
| evaluating the role of the 620w allele of protein tyrosine phosphatase ptpn22 in crohn's disease and multiple sclerosis. | the 620w allele of ptpn22 has been associated with susceptibility to several different forms of chronic inflammatory disease, including type 1 diabetes (t1d), rheumatoid arthritis (ra), systemic lupus erythematosus (sle), and autoimmune thyroiditis (ait). we set out to explore its possible role in two other inflammatory diseases: multiple sclerosis (ms) and crohn's disease (cd). in our cohort of 496 ms trios from the united kingdom, we observed reduced transmission of the ptpn22 620w allele. the ... | 2006 | 16391555 |
| electrophysiological characterization of three non-synonymous single nucleotide polymorphisms (r87q, a251t, and p307s) found in hkv1.5. | non-synonymous single nucleotide polymorphisms (snps) in the kcna5/hkv1.5 gene, which encodes for a voltage-gated k+ channel responsible for the i (kur) current in the human atria, have been recently reported. to gain further knowledge on potential influence of hkv1.5 snps, we searched for their presence in a specific population of 96 french-canadians and characterized electrophysiological properties of the variants in two cell lines. the presumed promoter (-83 bp) and coding regions were sequen ... | 2006 | 16411137 |
| modeling the sexual transmissibility of human papillomavirus infection using stochastic computer simulation and empirical data from a cohort study of young women in montreal, canada. | the authors estimated plausible ranges of the probability of human papillomavirus (hpv) transmission per coital act among newly forming couples by using stochastic computer simulation. comparative empirical data were obtained in 1996-2001 from a cohort study of female university students in montreal, canada. female prevalence and frequency of sexual intercourse and condom use were set equal to those in the cohort. simulations included 240 combinations of male prevalence, the relative risk for pr ... | 2006 | 16421235 |
| seasonal variance in serum levels of vitamin d determines a compensatory response by parathyroid hormone: study in an ambulatory elderly population in quebec. | although the seasonal variance in serum levels of vitamin d in the elderly is well known, its significance on parathyroid hormone (pth) remains controversial. | 2006 | 16439822 |
| the makeover of the lakeshore general hospital laboratories. | this article describes the expansion and reorganization of a moderate-sized canadian laboratory from day one to "live day." the key factors to the success of this project were organized planning by the laboratory staff and the introduction of core lab theories, team building, and organized training sessions. the successful makeover resulted in improved turnaround time for stat tests, especially those coming from the emergency unit. the efforts of the laboratory personnel toward the improvement o ... | 2006 | 16448593 |
| fluoride's effect on human dentin ultrasound velocity (elastic modulus) and tubule size. | despite fluoride (f) use in caries prevention, not much is known about its effects on tooth quality. this study evaluated the effect of tooth f concentration ([f]) on selected dentin structural and mechanical properties. third molars (n = 136) from toronto, which has 1 part per million (p.p.m.) water [f], montreal (0.2 p.p.m. water [f]), and fortaleza (brazil) (0.7 p.p.m. water [f]), were analyzed for [f], dental fluorosis (df) severity, ultrasound velocity, and dentin tubule size and density. t ... | 2006 | 16460346 |
| conditions that influence the elimination of postural constraints after office employees working with vdu have received ergonomics training. | the goal of this article is to better understand how preventive measures are undertaken after training. it examines how certain variables, such as musculoskeletal pain, participant age and workstation and work content characteristics influence the reduction of postural constraints after office employees working with a computer have received ergonomics training. | 2006 | 16477108 |
| due process--right to medical access--supreme court of canada holds that ban on private health insurance violates quebec charter of human rights and freedoms--chaoulli v. quebec (attorney general), 2005 s.c.c. 35, 29272, [2005] s.c.j. no. 33 quicklaw (june 9, 2005). | | 2005 | 16489720 |
| relationship between platelet monoamine oxidase-b (mao-b) activity and mercury exposure in fish consumers from the lake st. pierre region of que., canada. | mercury (hg) is a widespread neurotoxic compound that bio-accumulates in fish and marine mammals. monoamine oxidase (mao; ec 1.4.3.4) regulates biogenic amine concentration in the brain and peripheral tissue and has been shown to be a molecular target of hg compounds in animal models. blood platelet monoamine oxidase-b (mao-b) activity may reflect mao function in the central nervous tissue. therefore, the objective of this study was to evaluate the relationship between platelet mao-b and hg expo ... | 2006 | 16494947 |
| opportunities for student physical activity in elementary schools: a cross-sectional survey of frequency and correlates. | the objectives of this study were to describe opportunities for student physical activity (pa) in elementary schools and to identify factors in the school environment associated with higher pa opportunity. self-report questionnaires were completed by school principals and physical education teachers in 277 schools (88% response) in metropolitan montreal. correlates of opportunity were identified using ordinal logistic regression. there was substantial variation in pa opportunities between school ... | 2006 | 16531514 |
| implementing practice guidelines: a workshop on guidelines dissemination and implementation with a focus on asthma and copd. | the present supplement summarizes the proceedings of the symposium "implementing practice guidelines: a workshop on guidelines dissemination and implementation with a focus on asthma and copd", which took place in quebec city, quebec, from april 14 to 16, 2005. this international symposium was a joint initiative of the laval university office of continuing medical education (bureau de la formation médicale continue), the canadian thoracic society and the canadian network for asthma care, and was ... | 2006 | 16552449 |
| randomized controlled trial of human papillomavirus testing versus pap cytology in the primary screening for cervical cancer precursors: design, methods and preliminary accrual results of the canadian cervical cancer screening trial (cccast). | since infection with oncogenic human papillomavirus (hpv) has been considered a necessary cause of cervical cancer, tests for oncogenic hpv types have been proposed as adjuncts or replacements to pap cytology. we designed the canadian cervical cancer screening trial (cccast) to compare the relative efficacy of hpv dna testing and pap cytology in primary screening for cervical cancer and its high-grade precursors. cccast randomized women aged 30-69 years in montreal (quebec) and in st. john's (ne ... | 2006 | 16572425 |
| canadian listeriosis reference service. | listeria monocytogenes, a psychrotrophic organism capable of growing at refrigeration temperatures, is of major concern in extended shelf life, refrigerated foods. considering that as much as 80-90% of human listeriosis cases are linked to the ingestion of contaminated food, human cases are predominantly seen in high-risk individuals, including organ-transplant recipients, patients with aids and hiv-infected individuals, pregnant women, cancer patients, and the elderly. in 2001, the canadian lis ... | 2006 | 16602988 |
| does delta15n in river food webs reflect the intensity and origin of n loads from the watershed? | stable nitrogen isotope ratios (delta15n) were measured in invertebrates and fish collected from 82 river sites located in the saint-lawrence lowlands in québec, canada, to examine the relationship between aquatic biota delta15n and anthropogenic nitrogen (n) loads. mean delta15n values of all three trophic levels examined (primary consumers, predatory invertebrates and invertebrate-feeding fish) were highly correlated with total anthropogenic n loads on the watershed (kg n km-2 year-1; r2>0.61, ... | 2006 | 16616320 |
| prevalence and factors related to canadian workplace health programs. | this study documented the prevalence and factors related to workplace health programs in canada, including employee assistance programs (eaps), drug testing programs, and health promotion programs (hpps). | 2006 | 16619999 |
| identification of a novel c5l2 variant (s323i) in a french canadian family with familial combined hyperlipemia. | a functional acylation stimulating protein (asp) receptor, c5l2, has been recently identified in asp-responsive cells. impaired asp-mediated triglyceride synthesis has previously been described in a subset of hyperapolipoprotein b/familial combined hyperlipidemia subjects. | 2006 | 16627811 |
| antimicrobial susceptibilities of thermophilic campylobacter from humans, swine, and chicken broilers. | the aim of this study was to evaluate the incidence and the distribution of antimicrobial resistance, and the presence of genetic determinants of resistance, in campylobacter recovered from swine, poultry, and human populations in quebec. minimum inhibitory concentrations (mics) of 10 antimicrobial agents were determined by the agar dilution technique. polymerase chain reaction (pcr) was used to detect the teto determinant, and mutations in gyra were analyzed by sequencing and by mismatch amplif ... | 2006 | 16639939 |
| a new autosomal recessive spastic ataxia associated with frequent white matter changes maps to 2q33-34. | recessive ataxias are a heterogeneous group of diseases. we identified a group of 23 french-canadian cases belonging to 17 families affected by an autosomal recessive spastic ataxia associated with frequent white matter changes. the fact that 59% of these families have a genealogical relationship to the portneuf county of quebec suggests that this is a new form of ataxia with a regional founder effect. all cases present with cerebellar ataxia and spasticity. there is great intrafamilial and inte ... | 2006 | 16672289 |
| analysis of single nucleotide polymorphisms in genes in the chromosome 12q24.31 region points to p2rx7 as a susceptibility gene to bipolar affective disorder. | previous results from our genetic analyses using pedigrees from a french canadian population suggested that the interval delimited by markers on chromosome 12, d12s86 and d12s378, was the most probable genomic region to contain a susceptibility gene for affective disorders. association studies with microsatellite markers using a case/control sample from the same population (n = 427) revealed significant allelic associations between the bipolar phenotype and marker nbg6. since this marker is loca ... | 2006 | 16673375 |
| human parechovirus types 1, 2 and 3 infections in canada. | a new reverse transcription-polymerase chain reaction assay was developed for identification of 28 canadian human parechovirus (hpev) isolates, including 20 hpev-1, 3 hpev-2, and 5 hpev-3, recovered from 1985 to 2004. all hpev-1 isolates but 1 were genetically distinct from the harris reference strain. one hpev-2 isolate was related to the williamson strain; the other 2 were related to the connecticut strain. hpev-3 isolates clustered together. seventy-five percent of isolates were recovered dur ... | 2006 | 16707054 |
| ixodes scapularis ticks collected by passive surveillance in canada: analysis of geographic distribution and infection with lyme borreliosis agent borrelia burgdorferi. | passive surveillance for the occurrence of the tick ixodes scapularis say (1821) and their infection with the lyme borreliosis spirochaetes borrelia burgdorferi s.l. has taken place in canada since early 1990. ticks have been submitted from members of the public, veterinarians, and medical practitioners to provincial, federal, and university laboratories for identification, and the data have been collated and b. burgdorferi detected at the national microbiology laboratory. the locations of colle ... | 2006 | 16739422 |
| gay man launches suit over refusal to accept blood donation. | adrian lomaga, a mcgill law student who is gay, is suing héma-québec because it refuses to accept his blood donation. héma-québec, which is the blood collection agency for the province, imposes a lifetime ban on blood donations from men who have had sex with another man even once since 1977. the canadian blood services has the same policy. | 2006 | 16805009 |
| chaoulli decision resonates one year later. | | 2006 | 16818893 |
| a pharmacoepidemiology study of the interaction between atorvastatin and clopidogrel after percutaneous coronary intervention. | after percutaneous coronary intervention (pci), the antiplatelet drug clopidogrel is frequently used to prevent stent thrombosis. a concern has been raised that atorvastatin may competitively inhibit the metabolism of the prodrug clopidogrel to its active metabolites by the cytochrome p450 3a4 (cyp3a4) enzyme, thereby potentially negating its antiplatelet effect. the 30-day rates of adverse cardiovascular events (composite of death, myocardial infarction, 11 unstable angina, stroke or transient ... | 2006 | 16875906 |
| identifying potential receptors and routes of contaminant exposure in the traditional territory of the ouje-bougoumou cree: land use and a geographical information system. | great concern has been raised with respect to the 13 traplines that constitute the traditional territory of the ouje-bougoumou cree located in the james bay region of northern quebec, canada, with respect to mine wastes originating from three local mines. as a result, an "integrative risk assessment" was initiated consisting of three interrelated components: a comprehensive human health study, an assessment of the existing ecological/environmental database, and a land use/potential sites of conc ... | 2007 | 16897501 |
| relationship between climate, pollen concentrations of ambrosia and medical consultations for allergic rhinitis in montreal, 1994-2002. | the aim of this study is to evaluate the influence of meteorological factors on ambrosia pollen concentrations and its impact on medical consultations for allergic rhinitis of residents from various socio-economic levels in montréal (québec, canada) between 1994 and 2002. the study was conducted to recognize the sensitivity of pollen productivity to daily climate variability in order to estimate the consequences on human health vulnerability in the context of global climate change. information r ... | 2006 | 16899280 |
| the spanish influenza: a tale from my grandmother's day. | | 2006 | 16909722 |
| participatory ergonomic processes to reduce musculoskeletal disorders: summary of a québec experience. | this article critically reviews 11 participatory ergonomic interventions carried out in québec by the occupational health and safety research institute (irsst). in the introduction, the characteristics of the approach used are situated in relation to the literature on this subject. based on the "ergo team" formula, the approach aims to provide company personnel with the skills to analyze and correct hazardous workstations in relation to musculoskeletal disorders (msd), using an analysis process ... | 2006 | 16971759 |
| common polymorphisms in the promoter of the visfatin gene (pbef1) influence plasma insulin levels in a french-canadian population. | the adipokine visfatin (pbef1) exhibits insulin-mimetic effects and correlates strongly with visceral adiposity. we sequenced visfatin gene exons and 1,480 bp of the promoter in 23 individuals, including 18 individuals from the quebec family study (qfs) with varying degrees of abdominal visceral fat, assessed by computed tomography, and 5 individuals from the saguenay-lac-saint-jean region of québec. we identified a synonymous polymorphism in exon 7 (ser301ser) but no nonsynonymous mutations. we ... | 2006 | 17003359 |
| phylogenetic relationships, host affinity, and geographic structure of boreal and arctic endophytes from three major plant lineages. | although associated with all plants, fungal endophytes (microfungi that live within healthy plant tissues) represent an unknown proportion of fungal diversity. while there is a growing appreciation of their ecological importance and human uses, little is known about their host specificity, geographic structure, or phylogenetic relationships. we surveyed endophytic ascomycota from healthy photosynthetic tissues of three plant species (huperzia selago, picea mariana, and dryas integrifolia, repres ... | 2007 | 17005421 |
| mutation analysis and characterization of atr sequence variants in breast cancer cases from high-risk french canadian breast/ovarian cancer families. | ataxia telangiectasia-mutated and rad3-related (atr) is a member of the pik-related family which plays, along with atm, a central role in cell-cycle regulation. atr has been shown to phosphorylate several tumor suppressors like brca1, chek1 and tp53. atr appears as a good candidate breast cancer susceptibility gene and the current study was designed to screen for atr germline mutations potentially involved in breast cancer predisposition. | 2006 | 17010193 |
| a quantitative trait locus for body fat on chromosome 1q43 in french canadians: linkage and association studies. | to explore a quantitative trait locus (qtl) on human chromosome 1q affecting bmi, adiposity, and fat-free mass phenotypes in the quebec family study cohort. | 2006 | 17030972 |
| can virtual reality improve anatomy education? a randomised controlled study of a computer-generated three-dimensional anatomical ear model. | the use of computer-generated 3-dimensional (3-d) anatomical models to teach anatomy has proliferated. however, there is little evidence that these models are educationally effective. the purpose of this study was to test the educational effectiveness of a computer-generated 3-d model of the middle and inner ear. | 2006 | 17054617 |
| association study between the cx3cr1 gene and asthma. | cx3cr1, a fractalkine receptor, mediates cell-adhesive and migratory functions in inflammation. based on cx3cr1 expression observed in bronchial tissues of asthmatic subjects, we hypothesized that genetic variation at this locus may affect susceptibility to asthma. we carried out an association study and a haplotypic analysis with selected polymorphisms of the cx3cr1 in a familial asthmatic sample from a founder population. genetic analyses performed by fbat software showed five cx3cr1 single nu ... | 2006 | 17082760 |
| early infection and risk of childhood brain tumors (canada). | up to 15% of human cancers can be attributed to infections. currently there are no known associations between infective agents and childhood brain tumors. we explored childhood brain tumor risk associated with a variety of indicators of infection during gestation and childhood. | 2006 | 17111258 |
| [development and application of a clinical vignette to assess the quality of cancer care]. | in conjunction with a study focusing on the implementation and effect of an integrated care network for cancer patients in the monteregie region in quebec, the vignette research strategy was adopted to assess the quality of care provided by the interdisciplinary teams working with this clientele. this research strategy has only recently been used to assess professional practices. this article adopts a resolutely methodological angle in order to describe a rigorous, innovative, transferable exper ... | 2006 | 17149162 |
| resting metabolic rate and respiratory quotient: results from a genome-wide scan in the quebec family study. | genes influencing resting metabolic rate (rmr) and respiratory quotient (rq) represent candidate genes for obesity, type 2 diabetes, and the metabolic syndrome because of the involvement of these traits in energy balance and substrate oxidation. | 2006 | 17158439 |
| mutations in syne1 lead to a newly discovered form of autosomal recessive cerebellar ataxia. | the past decade has seen great advances in unraveling the biological basis of hereditary ataxias. molecular studies of spinocerebellar ataxias (sca) have extended our understanding of dominant ataxias. causative genes have been identified for a few autosomal recessive ataxias: friedreich's ataxia, ataxia with vitamin e deficiency, ataxia telangiectasia, recessive spastic ataxia of charlevoix-saguenay and ataxia with oculomotor apraxia type 1 (refs. 6,7) and type 2 (ref. 8). nonetheless, genes re ... | 2007 | 17159980 |
| heterozygote carrier testing in high schools abroad: what are the lessons for the u.s.? | the main value of carrier detection in the general population is to determine reproductive risks. in this manuscript i examine the practice of providing carrier screening programs in the school setting. while the data show that high school screening programs can achieve high uptake, i argue that this may reflect a lack of full understanding about risks, benefits, and alternatives, and the right not to know. it may also reflect the inherent coercion in group testing, particularly for adolescents ... | 2006 | 17199818 |
| adiponectin and adiponectin receptor gene variants in relation to resting metabolic rate, respiratory quotient, and adiposity-related phenotypes in the quebec family study. | despite adiponectin's presumed role in fatty acid oxidation and energy homeostasis, little is known about the effect of gene variants on substrate oxidation, energy expenditure, and adiposity-related phenotypes. | 2007 | 17209173 |
| the low seroprevalence of tick-transmitted agents of disease in dogs from southern ontario and quebec. | infectious diseases caused by pathogens transmitted by ticks and other insect vectors are an important cause of morbidity and mortality in both dogs and humans throughout north america. the purpose of this study was to determine the seroprevalence of selected vector-transmitted pathogens in southern ontario and quebec. samples submitted to the vector borne disease diagnostic laboratory (vbddl) at the north carolina state university college of veterinary medicine were evaluated for antibodies to ... | 2006 | 17217089 |
| exploring the effects of telehealth on medical human resources supply: a qualitative case study in remote regions. | the availability of medical human resource supply is a growing concern for rural and remote communities in many countries. in the last decade, various telehealth experiences in canada have highlighted the potential impact of this technology on professional practice. the purpose of this study was to explore physicians' and managers' perceptions regarding the potential of telehealth to support recruitment and retention of physicians in remote and rural regions. | 2007 | 17217534 |
| associations between usf1 gene variants and cardiovascular risk factors in the quebec family study. | cardiovascular (cvd) risk factors are under the influence of environmental and genetic factors. human upstream transcription factor 1 gene (usf1) encodes for a transcription factor, which modulates the expression of genes involved in lipid and carbohydrate metabolic pathways. the aim of this study was to test the hypothesis that usf1 gene variants are associated with cvd risk factors in the quebec family study (qfs). usf1 has been sequenced in 20 qfs subjects with high plasma apolipoprotein b100 ... | 2007 | 17309647 |
| high rates of forward transmission events after acute/early hiv-1 infection. | a population-based phylogenetic approach was used to characterize human immunodeficiency virus (hiv)-transmission dynamics in quebec. | 2007 | 17330784 |
| excess transmission of the nad(p)h:quinone oxidoreductase 1 (nqo1) c609t polymorphism in families of children with acute lymphoblastic leukemia. | topoisomerase ii is a dna-processing enzyme, and secondary acute myeloid leukemia has been associated with exposure to drugs that inhibit its action. hence, prenatal exposure to chemicals that inhibit topoisomerase ii could plausibly contribute to the incidence of childhood leukemia. the nad(p)h:quinone oxidoreductase 1 (nqo1) enzyme is involved in the metabolism of topoisomerase ii-inhibiting chemicals. a functional polymorphism (c609t) associated with reduced activity has been identified on th ... | 2007 | 17332311 |
| montréal statement on the human right to essential medicines. | | 2007 | 17345971 |
| [mutations in syne-1 lead to a newly discovered form of autosomal recessive cerebellar ataxia]. | | 2007 | 17349286 |
| additive effects of obesity and tcf7l2 variants on risk for type 2 diabetes among cardiac patients. | | 2007 | 17351281 |
| genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol. | coronary artery disease (cad) is a major health concern in both developed and developing countries. with a heritability estimated at ~50%, there is a strong rationale to better define the genetic contribution to cad. this project involves the analysis of 884 individuals from 142 families (with average sibships of 5.7) as well as 558 case and control subjects from the saguenay lac st-jean region of northeastern quebec, with the use of 1,536 single-nucleotide polymorphisms (snps) in 103 candidate ... | 2007 | 17357073 |
| quantitative trait locus on 15q for a metabolic syndrome variable derived from factor analysis. | the metabolic syndrome represents a cluster of cardiovascular risk factors co-occurring in the same individual. the aim of this study was to identify chromosomal regions encoding genes predisposing to the metabolic syndrome using composite factors derived from maximum likelihood-based factor analysis. genetic data were obtained from the quebec family study and included 707 subjects from 264 nuclear families. factor analyses were performed on eight metabolic syndrome-related phenotypes including ... | 2007 | 17372302 |
| evaluation of a hybrid system for three-dimensional measurement of trunk posture in motion. | ambulatory assessment of trunk posture is important in improving our understanding of the risk of low back injury. recently, small inertial sensors combining accelerometers, gyroscopes and magnetometers were developed and appear to be promising for measuring human movement. however, the validity of such sensors for assessing three-dimensional (3d) trunk posture in motion has not been documented. the purpose of this study was to evaluate a hybrid system (hs) composed of two inertial sensors for t ... | 2007 | 17382283 |
| comparison of antimicrobial resistance of campylobacter jejuni isolated from humans, chickens, raw milk, and environmental water in québec. | this study compares the occurrence of antimicrobial resistance to erythromycin, ciprofloxacin, and tetracycline among 384 campylobacter jejuni isolates from humans (245), fresh whole retail chickens (56), raw milk (33), and environmental water (41) collected between 2000 and 2003 in québec, canada. resistance to ciprofloxacin was significantly more frequent in human isolates acquired abroad than in those acquired locally (50 versus 5.9%; p < 0.001); ciprofloxacin resistance was almost absent in ... | 2007 | 17388066 |
| the place of culture in forensic psychiatry. | members of a multicultural society must all be subject to the same equitable system of justice. however, culture exerts profound influences on human behavior, and cultural considerations have a place in determinations of capacity and in appropriate sentencing. cultural psychiatry can contribute to forensic psychiatry by helping to contextualize individuals' actions and experiences. this contextualizing can be done through cultural consultations that employ interpreters and culture brokers to ide ... | 2007 | 17389351 |
| deafblindness in french canadians from quebec: a predominant founder mutation in the ush1c gene provides the first genetic link with the acadian population. | usher syndrome type 1 (ush1) is the leading cause of deafblindness. in most populations, many private mutations are distributed across the five known ush1 genes. we investigated patients from the french canadian population of quebec (approximately 6 million people) that descends from about 8,500 french settlers who colonized the st lawrence river valley between 1608 and 1759. we hypothesized that founder mutations in ush1 genes exist in this population. | 2007 | 17407589 |
| evaluation of the health impact of lowering the formaldehyde occupational exposure limit for quebec workers. | this study aimed at assessing the impact on irritating effects of lowering the current occupational exposure limit (oel) for formaldehyde in occupational settings in the province of quebec, canada, from a 2 ppm ceiling value to 1, 0.75 or 0.3 ppm. this was achieved through (i) a re-assessment of the exposure-response relationship based on a pooled analysis of published controlled human studies on the incidence of the most sensitive effects related to acute formaldehyde exposure (irritation of th ... | 2007 | 17408825 |
| costs of rheumatoid arthritis: new estimates from the human capital method and comparison to the willingness-to-pay method. | individuals' valuation of changes in health states in monetary terms have been measured by examining changes in the direct and indirect costs of disease and by the willingness-to-pay (wtp) methodology. | 2007 | 17409364 |
| insulin-like growth factor-i and risk of high-grade cervical intraepithelial neoplasia. | insulin-like growth factors (igf) and their binding proteins (igfbp) have been implicated in the risk of several epithelial or glandular tumors, including prostate cancer, breast cancer, and colon cancer. cervical cancer, which is also of epithelial origin, has been shown to overexpress receptors for igf-i, and plasma levels of igf-i have been positively associated with cervical cancer precursors in one epidemiologic study. in this case-control study, we investigated plasma levels of igf-i and i ... | 2007 | 17416762 |
| protection strategies for drinking groundwater sources in small quebec municipalities. | awareness of groundwater protection has increased substantially in recent decades. in the province of quebec, canada, the groundwater catchment regulation (gwcr) was promulgated in 2002 to protect water quality in public wells. the goal of the present study was to document groundwater protection in the context of emerging regulations and identify factors explaining the propensity of municipalities applying protection strategies. two types of information were used in this study: data from a quest ... | 2008 | 17418933 |
| characterization of a novel spg3a deletion in a french-canadian family. | hereditary spastic paraplegias (hsps) are characterized by progressive lower limb spasticity and weakness. mutations in the spg3a gene, which encodes the large guanosine triphosphatase atlastin, are the second most common cause of autosomal dominant hereditary spastic paraplegia. in a large spg3a screen of 70 hereditary spastic paraplegia subjects, a novel in-frame deletion, p.del436n, was identified. characterization of this deletion showed that it affects neither the guanosine triphosphatase a ... | 2007 | 17427918 |
| restructuring of the québec health network and its effects on the profession of home health aides and their occupational health and safety. | the québec health sector is facing profound macroeconomic and macro-organizational changes. this article addresses the impact of these changes on the work of home health aides (hhas) and their occupational health and safety (ohs). the study was carried out in the home care services of four local community service centers (clscs) with different organizational characteristics. it is based on an analysis by triangulation of 66 individual and group interviews, 11 work days, and 35 multidisciplinary ... | 2007 | 17434861 |
| is work in education child's play? understanding risks to educators arising from work organization and design of work spaces. | the educational sector exposes its primarily female work force to numerous psychosocial risk factors. at the request of the education workers', ergonomists developed a participatory research project in order to understand the determinants of the difficulties experienced by special education technicians. these technicians work with students presenting behavioral and learning difficulties as well as developmental and mental health problems. eighteen technicians were interviewed and the work of sev ... | 2007 | 17434862 |
| the effect of maternal care on child survival: a demographic, genetic, and evolutionary perspective. | models of population dynamics generally assume that child survival is independent of maternal survival. however, in humans, the death of a mother compromises her immature children's survival because children require postnatal care. a child's survival therefore depends on her mother's survival in years following her birth. here, we provide a model incorporating this relationship and providing the number of children surviving until maturity achieved by females at each age. using estimates of the e ... | 2007 | 17492968 |
| balancing organ quality, hla-matching, and waiting times: impact of a pediatric priority allocation policy for deceased donor kidneys in quebec. | deceased donor kidney allocation policy must balance the desire for high-quality organs, good human leukocyte antigen (hla) matching, and minimal waiting times. we describe a 10-fold reduction in waiting times and an improvement in nonimmunologic indices of organ quality for child recipients after a change in organ allocation policy in quebec, canada. the new policy gives first priority to children (<18 yr) irrespective of hla matching or waiting time. hla matching after the policy change was pr ... | 2007 | 17565312 |
| diisocyanate conjugate and immunoassay characteristics influence detection of specific antibodies in hdi-exposed workers. | the structural characteristics of diisocyanate chemical protein antigens vary depending upon the methods of production, and may influence diisocyanate antigen immunoassays. the impact of different antigen preparation methods on immunoassay sensitivity, specificity, and predictive value for identifying workers with diisocyanate asthma (da) has not been systematically evaluated. | 2007 | 17581205 |
| spg4 founder effect in french canadians with hereditary spastic paraplegia. | the most common cause of autosomal dominant hereditary spastic paraplegia (hsp) is mutations in the spg4 gene. we have previously identified novel spg4 mutations in a collection of north american families including the c.g1801a mutation present in two families from quebec. the aim of this study is to estimate the frequency of the c.g1801a mutation in the french canadian (fc) population and to determine whether this mutation originates from a common ancestor. | 2007 | 17598600 |
| analysis and classification of the tools for assessing the risks associated with industrial machines. | to assess and plan future risk-analysis research projects, 275 documents describing methods and tools for assessing the risks associated with industrial machines or with other sectors such as the military, and the nuclear and aeronautics industries, etc., were collected. these documents were in the format of published books or papers, standards, technical guides and company procedures collected throughout industry. from the collected documents, 112 documents were selected for analysis; 108 metho ... | 2007 | 17599792 |
| virus occurrence in municipal groundwater sources in quebec, canada. | a 1 year study was undertaken on groundwater that was a source of drinking water in the province of quebec, canada. twelve municipal wells (raw water) were sampled monthly during a 1 year period, for a total of 160 samples. using historic data, the 12 sites were categorized into 3 groups: group a (no known contamination), group b (sporadically contaminated by total coliforms), and group c (historic and continuous contamination by total coliforms and (or) fecal coliforms). bacterial indicators (t ... | 2007 | 17668028 |
| evidence of linkage and association with body fatness and abdominal fat on chromosome 15q26. | in the present study, we undertook a two-step fine mapping of a 20-megabase region around a quantitative trait locus previously reported on chromosome 15q26 for abdominal subcutaneous fat (asf) in an extended sample of 707 subjects from 202 families from the quebec family study. | 2007 | 17712124 |
| novel sacs mutation in a belgian family with sacsin-related ataxia. | the authors describe the four patients in the first known belgian family with autosomal recessive spastic ataxia of charlevoix-saguenay (arsacs). a novel homozygous missense mutation, nm_014363.3: c.3491t>a in exon 9, of the sacs gene was identified in the present family, which results in an original amino acid of methionine to lysine substitution at amino acid residue 1164 (p.m1164k). although the cardinal clinical features, i.e., spastic ataxia with peripheral neuropathy, in our patients were ... | 2008 | 17716690 |
| ataxia-oculomotor apraxia 2 patients show no increased sensitivity to ionizing radiation. | mutations in senataxin have been described recently in 24 cases of french-canadian descent with ataxia-oculomotor apraxia 2. this recessive ataxia is associated with an elevation in alpha-fetoprotein as in ataxia-telangiectasia. because ataxia-telangiectasia cells are highly radiosensitive, we used a colony survival assay to measure the radiosensitivity of lymphoblastoid cell lines derived from five french-canadian patients with ataxia-oculomotor apraxia 2. two were homozygous for the common fre ... | 2007 | 17720498 |
| three provinces to study 2-dose hpv vaccine. | | 2007 | 17724315 |
| lrrk2 is not a significant cause of parkinson's disease in french-canadians. | an old founder mutation (g2019s) was found with high frequency in the north african arabs (30%) and ashkenazi jews (18% ). objective: demonstrate if mutations in the lrrk2 gene are a significant cause of parkinson's disease (pd) in the french-canadian founder population. | 2007 | 17803032 |