| in vitro emergence of fluoroquinolone resistance in cutibacterium (formerly propionibacterium) acnes and molecular characterization of mutations in the gyra gene. | in vitro occurrence of levofloxacin (lvx) resistance in c. acnes and characterization of its molecular background were investigated. the mutation frequency was determined by inoculation of 10(8) cfu of c. acnes atcc 11827 (lvx mic = 0.25 mg/l) on lvx-containing agar plates. the progressive emergence of resistance was studied by a second exposure to increasing lvx concentrations. for mutants, the qrdr regions including the gyra and parc genes were sequenced and compared to both c. acnes atcc 1182 ... | 2017 | 28602804 |
| erratum to: high incidence of periprosthetic joint infection with propionibacterium acnes after the use of a stemless shoulder prosthesis with metaphyseal screw fixation - a retrospective cohort study of 241 patients propionibacter infections after eclipse tsa. | | 2017 | 28595609 |
| genetic architecture of acne vulgaris. | acne vulgaris is a ubiquitary skin disease characterized by chronic inflammation of the pilosebaceous unit resulting from bacterial colonization of hair follicles by propionibacterium acnes, androgen-induced increased sebum production, altered keratinization and inflammation. | 2017 | 28593717 |
| an unusual pathogen causing native valve endocarditis. | we present the case of a gentleman who was being evaluated for restrictive lung disease and was incidentally found to have mitral valve stenosis on an hrct. during the surgical procedure for valve replacement, he was found to have an abscess around the native mitral valve which was drained. pus from the abscess as well as the valve tissue grew propionibacterium acnes after holding the cultures long. the patient was treated with iv ceftriaxone with good response to therapy. while propionibacteriu ... | 2017 | 28586598 |
| detection of the relatively slow-growing propionibacterium acnes in seven matrices of blood components and advanced therapeutical medicinal products. | relatively slow-growing bacteria like propionibacterium acnes represent a challenge for quality control investigations in sterility release testing of blood components and advanced therapeutic medicinal products (atmps). | 2017 | 28571932 |
| endocrine disorders and hormonal therapy for adolescent acne. | acne vulgaris is a global disease with increasing prevalence in adolescents. it has a profound impact on their quality of life, especially when endocrine disorders are also involved. recent concerns regarding antibiotic stewardship, failures with antibiotic usage, and the development of antibiotic-resistant propionibacterium acnes have led clinicians to consider other therapeutic options for acne treatment. the present review explores hormonal therapies for the treatment of acne vulgaris. | 2017 | 28562419 |
| effect of propionibacterium acnes (pa) injection on intervertebral disc degeneration in a rat model: does it mimic modic changes? | multiple reports of bacterial isolates in human disc tissue have suggested a role of low-grade infection on intervertebral disc degeneration and modic changes (mc) generation. animal models have been extensively used to study idd; however, until recently, no consideration had been given to eventual infectious processes. to reproduce the phenomena by inoculating an infecting agent would support the infectious hypothesis. therefore, we studied the effect of propionibacterium acnes (pa) inoculation ... | 2017 | 28552835 |
| commercial essential oils as potential antimicrobials to treat skin diseases. | essential oils are one of the most notorious natural products used for medical purposes. combined with their popular use in dermatology, their availability, and the development of antimicrobial resistance, commercial essential oils are often an option for therapy. at least 90 essential oils can be identified as being recommended for dermatological use, with at least 1500 combinations. this review explores the fundamental knowledge available on the antimicrobial properties against pathogens respo ... | 2017 | 28546822 |
| the follicular skin microbiome in patients with hidradenitis suppurativa and healthy controls. | although the pathogenesis of hidradenitis suppurativa (hs) remains enigmatic, several factors point to potential involvement of the cutaneous microbiome. insight into the cutaneous microbiome in hs using next-generation sequencing may provide novel data on the microbiological diversity of the skin. | 2017 | 28538949 |
| response to: can 16s rrna pcr be the solution for a rapid detection of propionibacterium acnes in surgical shoulder or spine samples? comments on "a rapid method for detecting propionibacterium acnes in surgical biopsy specimens from the shoulder". | | 2017 | 28526425 |
| can 16s rrna pcr be the solution for a rapid detection of propionibacterium acnes in surgical shoulder or spine samples? comments on "a rapid method for detecting propionibacterium acnes in surgical biopsy specimens from the shoulder". | | 2017 | 28526424 |
| high incidence of periprosthetic joint infection with propionibacterium acnes after the use of a stemless shoulder prosthesis with metaphyseal screw fixation - a retrospective cohort study of 241 patients propionibacter infections after eclipse tsa. | a stemless shoulder prosthesis with humeral metaphyseal screw fixation was introduced in order to save bone-stock and to facilitate reconstruction of biomechanics (eclipse®). the aim of this study was to analyze whether the risk of infection is different with this implant compared to conventional shoulder prosthesis. | 2017 | 28526023 |
| periprosthetic shoulder infection: an overview. | periprosthetic shoulder infection (psi) is rare but potentially devastating. the rate of psi is increased in cases of revision procedures, reverse shoulder implants and co-morbidities. one specific type of psi is the occurrence of low-grade infections caused by non-suppurative bacteria such as propionibacterium acnes or staphylococcus epidemermidis.success of treatment depends on micro-organism identification, appropriate surgical procedures and antibiotic administration efficiency. post-operati ... | 2017 | 28507783 |
| sapho, autophagy, il-1, foxo1, and propionibacterium (cutibacterium) acnes. | overt infection by propionibacterium acnes is lacking in many sapho syndromes, and antibiotics have only a transient and incomplete effect, either in sapho syndrome or acne. as several auto-inflammatory bone disorders sharing overproduction of il-1β can mimic sapho, this syndrome could partly depend on genetically encoded overproduction of il-1β. however, cyclic intracellular infections, mostly by p. acnes, can contribute to the enhanced il-1β release by some skin cells, and probably by bone cel ... | 2017 | 28499891 |
| post-operative spondylodiscitis due to propionibacterium acnes: a case report. | post-operative spondylodiscitis due to propionibacterium acnes is rare, with only a few cases reported in the literature. in this article, we report the case of a 76-year-old patient who suffered from spondylodiscitis t12-l1 discovered after 1 month of pain and fever. antibiotic treatment was administered for 6 weeks without revision surgery. diagnosis remains incomplete, and preventive therapy against this infection is not well known. there is no link between immunosuppression and this infectio ... | 2017 | 28495228 |
| delayed manifestation of shunt nephritis: a case report and review of the literature. | we present an unusual case of shunt nephritis in a 39-year-old male who presented 21 years after placement of a ventriculoperitoneal (vp) shunt. he complained of fevers, headaches, dizziness, and urticarial plaques on arms, trunks, and legs and was found to have anemia, low complement levels, elevated serum creatinine, proteinuria, and new onset microhematuria. blood and urine cultures were negative. renal biopsy showed features of acute tubulointerstitial nephritis attributed to vancomycin use. ... | 2017 | 28487790 |
| benzoyl peroxide and clindamycin topical skin preparation decreases propionibacterium acnes colonization in shoulder arthroscopy. | propionibacterium acnes is a gram-positive anaerobe that can lead to devastating postoperative shoulder infections. the objective of this study was to investigate whether a benzoyl peroxide and clindamycin preoperative skin preparation reduces the incidence of p. acnes colonization during shoulder arthroscopy. | 2017 | 28479255 |
| green synthesis of conjugated linoleic acids from plant oils using a novel synergistic catalytic system. | a novel and efficient method has been developed for converting plant oil into a specific conjugated linoleic acid (cla) using a synergistic biocatalytic system based on immobilized propionibacterium acnes isomerase (pai) and rhizopus oryzae lipase (rol). pai exhibited the greatest catalytic activity when immobilized on d301r anion-exchange resin under optimal conditions (pai dosage of 12 410 u of pai/g of d301r, glutaraldehyde concentration of 0.4%, and reaction conditions of ph 7.0, 25 °c, and ... | 2017 | 28470063 |
| reduction in bacterial load using hypochlorous acid hygiene solution on ocular skin. | to examine the magnitude of bacterial load reduction on the surface of the periocular skin 20 minutes after application of a saline hygiene solution containing 0.01% pure hypochlorous acid (hocl). | 2017 | 28458509 |
| tropism and virulence of cutibacterium (formerly propionibacterium) acnes involved in implant-associated infection. | the recognition of the pathogenicity of cutibacterium acnes in implant-associated infection is not always obvious. in this paper, we aimed to distinguish pathogenic and non-pathogenic c. acnes isolates. to reach this goal, we investigated the clonal complex (cc) of a large collection of c. acnes clinical isolates through multi-locus sequence typing (mlst), we established a caenorhabditis elegans model to assess c. acnes virulence and we investigated the presence of virulence factors in our colle ... | 2017 | 28454760 |
| a comparative study of cutibacterium (propionibacterium) acnes clones from acne patients and healthy controls. | cutibacterium (propionibacterium) acnes is assumed to play an important role in the pathogenesis of acne. | 2017 | 28434779 |
| the microbiome of the prostate tumor microenvironment. | the advent of molecular-based methods of identification and characterization of complex microbial populations has led to a new era of microbial discovery. a detailed and comprehensive analysis of the microbial ecosystem of the pathologic and healthy prostate tissues has not been yet reported. | 2017 | 28434677 |
| histological identification of propionibacterium acnes in nonpyogenic degenerated intervertebral discs. | purpose. low-virulence anaerobic bacteria, especially the propionibacterium acnes (p. acnes), have been thought to be a new pathogeny for a series of disc diseases. however, until now, there has been no histological evidence to confirm this link. the purpose of this study was to confirm the presence of p. acnes in nonpyogenic intervertebral discs via histological observation. method. degenerated intervertebral discs were harvested from 76 patients with low back pain and/or sciatica but without a ... | 2017 | 28401158 |
| propionibacterium acnes incubation in the discs can result in time-dependent modic changes: a long term rabbit model. | a case control study of animal model of modic changes (mcs) on rabbits. | 2017 | 28399545 |
| antibacterial activity of ethanolic extract of cinnamon bark, honey, and their combination effects against acne-causing bacteria. | propionibacterium acnes and staphylococcus epidermidis are the major skin bacteria that cause the formation of acne. the present study was conducted to investigate antibacterial activity of ethanolic extract of cinnamon bark, honey, and their combination against acne bacteria. the antibacterial activity of extract of cinnamon bark and honey were investigated against p. acnes and s. epidermidis using disc diffusion. minimum inhibitory concentrations (mics) and minimum bactericidal concentrations ... | 2017 | 28398231 |
| antibacterial and laxative activities of strictinin isolated from pu'er tea (camellia sinensis). | strictinin, the major phenolic compound in pu'er teas produced from young leaves and buds of wild trees, was isolated to evaluate its antibacterial and laxative activities. the minimum inhibitory concentrations of strictinin against propionibacterium acnes and staphylococcus epidermidis were determined as 250 μm and 2000 μm, respectively, apparently higher than those of several antibiotics commonly used for bacterial infections. the additive and synergistic effects on the inhibitory activities o ... | 2016 | 28911609 |
| susceptibility of enterococcus faecalis and propionibacterium acnes to antimicrobial photodynamic therapy. | bacterial resistance to available antibiotics nowadays is a global threat leading researchers around the world to study new treatment modalities for infections. antimicrobial photodynamic therapy (apdt) has been considered an effective and promising therapeutic alternative in this scenario. briefly, this therapy is based on the activation of a non-toxic photosensitizing agent, known as photosensitizer (ps), by light at a specific wavelength generating cytotoxic singlet oxygen and free radicals. ... | 2018 | 29253813 |
| photodynamic action of the red laser on propionibacterium acnes. | photodynamic therapy is a therapeutic modality that has consolidated its activity in the photooxidation of organic matter, which arises from the activity of reactive oxygen species. | 2017 | 29166495 |
| subclinical propionibacterium acnes infection estimation in the intervertebral disc (spine-id): protocol for a prospective cohort. | low back pain and vertebral endplate abnormalities are common conditions within the population. subclinical infection caused by indolent pathogens can potentially lead to these findings, with differentiation between them notably challenging from a clinical perspective. progressive infection of the intervertebral disc has been extensively associated with increasing low back pain, with propionibacterium acnes specifically implicated with in relation to sciatica. the main purpose of this study is t ... | 2017 | 29151051 |
| skin barrier and microbiome in acne. | acne is an immune-mediated chronic inflammatory disease. although several factors are involved in its pathophysiology, this process is not completely understood. androgen hormone activity increases sebum production inside the pilosebaceous follicle, adjusting the environment for the development of propionibacterium acnes which triggers inflammation. knowing how others factors such as the skin barrier and microbiome are involved in acne, can help in understanding more about the disease and may he ... | 2017 | 29147769 |
| [periodontal microbiota and microorganisms isolated from heart valves in patients undergoing valve replacement surgery in a clinic in cali, colombia]. | periodontitis is an infectious disease that affects the support tissue of the teeth and it is associated with different systemic diseases, including cardiovascular disease. microbiological studies facilitate the detection of microorganisms from subgingival and cardiovascular samples. | 2017 | 29373772 |
| on revealing the gene targets of ebola virus micrornas involved in the human skin microbiome. | ebola virus, a negative-sense single-stranded rna virus, causes severe viral hemorrhagic fever and has a high mortality rate. histopathological and immunopathological analyses of ebola virus have revealed that histopathological changes in skin tissue are associated with various degrees of endothelial cell swelling and necrosis. the interactions of microbes within or on a host are a crucial for the skin immune shield. the discovery of micrornas (mirnas) in ebola virus implies that immune escape, ... | 2018 | 29312814 |
| over a decade of reca and tly gene sequence typing of the skin bacterium propionibacterium acnes: what have we learnt? | the gram-positive, anaerobic bacteriumpropionibacterium acnesforms part of the normal microbiota on human skin and mucosal surfaces. while normally associated with skin health,p. acnesis also an opportunistic pathogen linked with a range of human infections and clinical conditions. over the last decade, our knowledge of the intraspecies phylogenetics and taxonomy of this bacterium has increased tremendously due to the introduction of dna typing schemes based on single and multiple gene loci, as ... | 2017 | 29267255 |
| virome and bacteriome characterization of children with pneumonia and asthma in mexico city during winter seasons 2014 and 2015. | acute asthma exacerbations and pneumonia are important causes of morbidity and mortality in children and may coexist in the same children, although symptom overlap may lead to difficulties in diagnosis. microbial and viral diversity and differential abundance of either may play an important role in infection susceptibility and the development of acute and chronic respiratory diseases. | 2018 | 29447223 |
| propionibacterium acnes has low susceptibility to chlorhexidine digluconate. | the skin bacterium propionibacterium acnes has been reported to be responsible for surgical site infections (ssis). skin disinfection before surgery therefore is of the utmost importance in the prevention of ssis caused by skin bacteria. | 2018 | 29447075 |
| preventing infection in shoulder surgery. | although rare, infection after shoulder surgery can represent a devastating complication. infection can negatively affect clinical outcomes, and eradication often requires a protracted treatment course. staphylococcus aureus, staphylococcus epidermidis, and propionibacterium acnes are among the most frequently isolated pathogens. perioperative measures can be implemented to reduce infection risk. here we review various perioperative practices and their efficacy at reducing infection after should ... | 2018 | 29444755 |
| propionibacterium acnesandstaphylococcus epidermidisolecranon bursitis/osteomyelitis: a case involving surgical and antibiotic treatment. | this report describes a 63-year-old generally healthy male with septic olecranon bursitis caused bypropionibacterium acnesthe patient sustained a small laceration after striking the posterior aspect of his left elbow on a metal railing when he was at a public swimming pool. we concluded thatp. acneswas not initially detected because cultures were only kept for 5 days. consequently, initial antibiotic treatment failed.p. acnesandstaphylococcus epidermidisgrew in a subsequent tissue culture. the i ... | 2018 | 29440139 |
| bacteriology and cefuroxime-resistance in endophthalmitis following cataract surgery before and after the introduction of prophylactic intracameral cefuroxime: a retrospective single-centre study. | intracameral cefuroxime as prophylaxis against postoperative endophthalmitis (poe) following cataract surgery was introduced in 1996 at st erik eye hospital. soon after the introduction of intracameral cefuroxime the rate of poe fell dramatically and a shift in the aetiology was noticed. | 2018 | 29432821 |
| dysbiosis of inferior turbinate microbiota is associated with high total ige levels in allergic rhinitis patients. | abnormalities in the human microbiota are associated with the etiology of allergic diseases. although disease site-specific microbiota may be associated with disease pathophysiology, the role of the nasal microbiota is unclear. we sought to characterize the microbiota of the site of allergic rhinitis, inferior turbinate, in subjects with allergic rhinitis (n=20) and healthy controls (n=12), and to examine the relationship of mucosal microbiota with disease occurrence, sensitized allergen number, ... | 2018 | 29426044 |
| topical delivery of erythromycin through cubosomes for acne. | topical delivery is an attractive route for local and systemic treatment. novel topical application has many advantages like avoids the gi-irritation, prevent the metabolism of drug in the liver and increase the bioavailability of the drug over the conventional dosage forms. the aim of present work was to prepared and characterized erythromycin encapsulated cubosomes using different concentration of glyceryl monooleate and poloxamer 407 by emulsification method. the prepared dispersion of cuboso ... | 2018 | 29424323 |
| periprosthetic joint infection of shoulder arthroplasties: diagnostic and treatment options. | periprosthetic joint infection (pji) is one of the most frequent reasons for painful shoulder arthroplasties and revision surgery of shoulder arthroplasties.cutibacterium acnes (propionibacterium acnes)is one of the microorganisms that most often causes the infection. however, this slow growing microorganism is difficult to detect. this paper presents an overview of different diagnostic test to detect a periprosthetic shoulder infection. this includes nonspecific diagnostic tests and specific te ... | 2017 | 29423407 |
| [progress on propionibacterium acnes and degenerative intervertebral disc]. | the mechanism of degenerative intervertebral disc is very complex, which may be associated with multiple factors such as the mechanical stress force injury of intervertebral disc, nutritional deficiency, inflammatory stimulation, etc. recently, many studies detected propionibacterium acnes(p. acnes) in degenerative intervertebral disc and supposed p. acnes was associated with degenerative intervertebral disc. here, the papers related to p. acnes and degenerative intervertebral disc were reviewed ... | 2017 | 29417784 |
| [pseudarthrosis and construct failure after lumbar pedicle subtraction osteotomy : influence of biomechanics, surgical technique, biology and avoidance strategies]. | there are numerous factors that can lead to construct failure and pseudarthrosis after corrective pedicle subtraction osteotomy (pso) in the lumbar spine. frequently, several factors are of relevance in these problematic cases. this article attempts to explain the surgical, biomechanical and biological aspects that should be understood in order to minimize the risk of pseudarthrosis and construct failure. it addresses technical varieties of the pso procedure as well as the surgical technique, th ... | 2018 | 29411050 |
| a rationally designed multi-functional antibiotic for the treatment of drug-resistant acne. | acne is a multifactorial skin disease, underpinned by colonization of propionibacterium acnes and inflammation. the emergence of resistant propionibacterium acnes strains has affected the current acne treatment algorithm. this setback served as an impetus for rationally designing a library of next-generation antibiotics that exhibit a bactericidal effect on resistant propionibacterium acnes as well as exert an immunomodulatory function to reduce inflammation. in silico screening revealed that on ... | 2018 | 29409921 |
| propionibacterium acnes-derived extracellular vesicles promote acne-like phenotypes in human epidermis. | acne vulgaris is an inflammatory disease occurring in the pilosebaceous unit and is the most common skin condition in young people. a gram-positive bacterium, propionibacterium acnes (p. acnes), has been suspected to contribute to the development of acne. here, we report that p. acnes constitutively releases extracellular vesicles (evs) exhibiting typical ev morphology and size. moreover, the p. acnes-derived evs (pevs) can induce acne-like phenotypes in human epidermal keratinocytes and a recon ... | 2018 | 29409885 |
| propionibacterium acnes-derived insoluble immune complexes in sinus macrophages of lymph nodes affected by sarcoidosis. | propionibacterium acnes is thought to be a causative agent of sarcoidosis. patients with sarcoidosis have circulating immune complexes. we attempted to detect p. acnes-derived immune complexes in sarcoid lesions. | 2018 | 29401490 |
| anaerobic bacterial meningitis in adults. | anaerobic infection is a very uncommon condition in adult bacterial meningitis (abm), and its clinical characteristics have yet to be clarified. we enrolled 540 patients with culture-proven bacterial meningitis during a study period of 30 years (1986-2015), of whom 13 (2.4%) had anaerobic infections. these 13 patients were eight men and five women, aged 22-77 years. among them, 53.8% (7/13) had a postneurosurgical state as the preceding event, and 79.6% (10/13) had underlying medical conditions ... | 2018 | 29396061 |
| propionibacterium acnes strains differentially regulate the fate of th17 responses in the skin. | agak et al. demonstrate that different strains of propionibacterium acnes, a bacterium colonizing pilosebaceous units in healthy skin and acne, have the ability to induce t helper type 17 cells secreting either ifn-γ or il-10 and exhibiting either pathogenic or protective properties, respectively. this work contributes to growing evidence indicating that the phenotype of t helper type 17 cells is largely dependent on their microbiological environment. | 2018 | 29389326 |
| epidermal growth factor attenuated the expression of inflammatory cytokines in human epidermal keratinocyte exposed topropionibacterium acnes. | while the beneficial effects of topical epidermal growth factor (egf) on wound healing have been repeatedly reported, there are few reports about the effects of egf on inflammatory skin diseases including acne. | 2018 | 29386833 |
| platelet activation and aggregation by the opportunistic pathogen cutibacterium (propionibacterium) acnes. | cutibacterium (propionibacterium) acnes, considered a part of the skin microbiota, is one of the most commonly isolated anaerobic bacteria from medical implants in contact with plasma. however, the precise interaction of c. acnes with blood cells and plasma proteins has not been fully elucidated. herein, we have investigated the molecular interaction of c. acnes with platelets and plasma proteins. we report that the ability of c. acnes to aggregate platelets is dependent on phylotype, with a sig ... | 2018 | 29385206 |
| propionibacterium acnes abundance correlates inversely with staphylococcus aureus: data from atopic dermatitis skin microbiome. | the microbiome may influence disease severity in atopic dermatitis. the skin of atopic dermatitis patients and healthy individuals was sampled in a standardized manner and the microbial composition analysed using next-generation sequencing. optical density measurements were used to investigate bacterial growth under defined conditions in vitro. lesional skin from patients with atopic dermatitis had a higher abundance of s. aureus and reduced quantities of propionibacterium acnes and lawsonella c ... | 2018 | 29379979 |
| propionibacterium acnes suture contamination in arthroscopic rotator cuff repair: a prospective randomized study. | to examine the contamination rate of the anchor-suture and to determine the efficacy of 2 different surgical skin preparation solutions with or without a plastic adhesive drape from suture contamination in arthroscopic rotator cuff repair. | 2018 | 29373294 |
| a profile of propionibacterium acnes resistance and sensitivity at a tertiary dermatological centre in singapore. | propionibacterium acnes (p. acnes) is a key component in the pathogenesis of acne. both topical and oral antibiotics are key therapeutic options. unfortunately, antibiotic resistance is rapidly increasing globally. many countries have reported greater than 50% of p.acnes strains acquiring resistance to topical macrolides1-3. in singapore, antibiotic resistance rates of 8% in 19994rising to 14.9%5in 2007 were reported. we aimed to update the local prevalence of antibiotic resistance and identify ... | 2018 | 29368337 |
| prevalence of propionibacterium acnes in the glenohumeral compared with the subacromial space in primary shoulder arthroscopies. | we hypothesized that the prevalence of propionibacterium acnes in patients undergoing primary shoulder arthroscopy is equal in the glenohumeral space compared with the subacromial space. | 2018 | 29361412 |
| the human skin microbiome. | functioning as the exterior interface of the human body with the environment, skin acts as a physical barrier to prevent the invasion of foreign pathogens while providing a home to the commensal microbiota. the harsh physical landscape of skin, particularly the desiccated, nutrient-poor, acidic environment, also contributes to the adversity that pathogens face when colonizing human skin. despite this, the skin is colonized by a diverse microbiota. in this review, we describe amplicon and shotgun ... | 2018 | 29332945 |
| shunt nephritis: an increasingly unfamiliar diagnosis. | shunt nephritis is a rare, reversible immune-complex mediated complication of csf shunt infection that can progress to end-stage renal disease and even death if diagnosis is delayed. | 2018 | 29325951 |
| propionibacterium acnes induces intervertebral disc degeneration by promoting nucleus pulposus cell apoptosis via the tlr2/jnk/mitochondrial-mediated pathway. | evidence suggests that intervertebral disc degeneration (ivdd) can be induced by propionibacterium acnes (p. acnes), although the underlying mechanisms are unclear. in this study, we analyzed the pathological changes in degenerated human intervertebral discs (ivds) infected with p. acnes. compared with p. acnes-negative samples, p. acnes-positive ivds showed increased apoptosis of nucleus pulposus cells (npcs) concomitant with severe ivdd. then, a p. acnes-inoculated ivd animal model was establi ... | 2018 | 29323102 |
| glenohumeral joint sepsis after joint injection through a new tattoo. | we report a case of propionibacterium acnes septic arthritis of a shoulder following two joint access procedures. methodical investigation of these two procedures was performed using the joint commission root cause analysis matrix, which involved examination of protocols, interviews with technologists and physicians, and inspection of the procedure rooms and equipment. no procedural error or other causal factor for infection was found other than the injection through a five day-old tattoo during ... | 2017 | 29296168 |
| a case of relapsing polychondritis mimicking hemophagocytic lymphohistiocytosis after propionibacterium acnes infection. | we describe a 69-year-old man who presented with a right sternocleidomastoid intramuscular abscess that grew propionibacterium acnes. despite initial improvement with antibiotics, he subsequently developed signs and symptoms fulfilling diagnostic criteria for hemophagocytic lymphohistiocytosis (hlh)-fevers, cytopenias, hyperferritinemia, splenomegaly, and low natural killer cell activity. the patient improved spontaneously but at outpatient follow-up complained of erythema over the bridge of his ... | 2017 | 29280824 |
| bacterial diversity in feline conjunctiva based on 16s rrna gene sequence analysis: a pilot study. | changes in the microbial populations in the conjunctival sacs of animals have traditionally been evaluated using conventional microbiology techniques. the goal of this study was to examine the suitability of a methodology which may reveal a previously unknown microbiome inhabiting feline conjunctival membranes. in the present study, we determined the microbial diversity in feline conjunctivas based on 16s rrna gene sequence analysis. five taxa not described earlier in veterinary ophthalmology (i ... | 2017 | 29279847 |
| topographical diversity of common skin microflora and its association with skin environment type: an observational study in chinese women. | this study evaluated cutaneous microbial distribution, and microbial co-occurrence at different body sites and skin environments in chinese women (39.6 ± 11.9 years, n = 100) during the winter season. microbial distribution (propionibacterium acnes, staphylococcus aureus, staphylococcus epidermidis, lactobacillus, pseudomonadaceae, and malassezia furfur), association with biomarkers (antimicrobial peptides: ll-37, β-defensins [hbd-2, hbd-3]), and claudin-1) and skin biophysical parameters (trans ... | 2017 | 29273721 |
| infection rate after cranial neurosurgical procedures: a prospective single-center study. | to determine infection rate (ir) and to identify modifiable risk factors (rf) in cranial neurosurgery in a neurosurgical department for tertiary referral as part of an infection control surveillance to reduce surgical site infections (ssi). | 2017 | 29269070 |
| culture-dependent approaches to explore the prevalence of root canal pathogens from endodontic infections. | endodontic infections are considered to be caused by the presence of various microorganisms within the root canal system. recognition of this microbiota contributes to the successful treatment of infected root canals. this study investigated the microorganisms associated with primary and secondary endodontic infections via culture methods, biochemical tests, and molecular approaches in an iranian population. microbial specimens were collected from 36 patients with primary endodontic infection an ... | 2017 | 29267669 |
| disseminated propionibacterium acnes infection in a 42-year-old hiv-positive man. | | 2017 | 29241870 |
| long-term administration of oral macrolides for acne treatment increases macrolide-resistant propionibacterium acnes. | macrolide-resistant propionibacterium acnes are frequently isolated from patients with acne vulgaris, and the most resistant isolates (>90% resistance) have the 23s rrna mutation. an increase in resistant p. acnes with this mutation is thought to be caused by the inappropriate use of antimicrobials. therefore, we studied the mutation frequency of macrolide resistance in p. acnes in vitro. when p. acnes mutants were exposed to clarithromycin after being incubated in broth without antimicrobials, ... | 2017 | 29235673 |
| acne in late adolescence and risk of prostate cancer. | accumulating evidence suggest that propionibacterium acnes may play a role in prostate carcinogenesis, but data are so far limited and inconclusive. the aim of this population-based cohort study was therefore to test whether presence of acne vulgaris during late adolescence is associated with an increased risk of prostate cancer later in life. we identified a large cohort of young men born in sweden between 1952 and 1956, who underwent mandatory assessment for military conscription around the ag ... | 2018 | 29205339 |
| cp and cp-pgn protect mice against mrsa infection by inducing m1 macrophages. | corynebacterium pyruviciproducens (c. pyruviciproducens, cp), as a newly discovered immunomodulator, has been confirmed to have a stronger immunoregulation than propionibacterium acnes (p. acnes) of the traditional immune adjuvant, by previous experiments with model antigen ovalbumin and sheep red blood cells. here, it was designed to assess its ability to resist methicillin-resistant staphylococcus aureus (mrsa), since mrsa as a vital gram positive pathogen is characterized by high morbidity an ... | 2017 | 29203871 |
| prevalence of flp pili-encoding plasmids incutibacterium acnesisolates obtained from prostatic tissue. | inflammation is one of the hallmarks of prostate cancer. the origin of inflammation is unknown, but microbial infections are suspected to play a role. in previous studies, the gram-positive, low virulent bacteriumcutibacterium(formerlypropionibacterium)acneswas frequently isolated from prostatic tissue. it is unclear if the presence of the bacterium represents a true infection or a contamination. here we investigatedcutibacterium acnestype ii, also called subspeciesdefendens, which is the most p ... | 2017 | 29201018 |
| g2a attenuatespropionibacterium acnesinduction of inflammatory cytokines in human monocytes. | acne vulgaris is a disease of the pilosebaceous unit characterized by increased sebum production, hyperkeratinization, and immune responses topropionibacterium acnes(pa). here, we explore a possible mechanism by which a lipid receptor, g2a, regulates immune responses to a commensal bacterium. | 2017 | 29200756 |
| propionibacterium acnes induces autophagy in keratinocytes: involvement of multiple mechanisms. | propionibacterium acnes is a dominant member of the cutaneous microbiota. herein, we evaluate the effects of different p. acnes strains and propionic acid on autophagy in keratinocytes. our results showed that p. acnes strain 889 altered the architecture of the mitochondrial network, elevated the levels of lc3b-ii, beclin-1 and phospho-ampkα, stimulated autophagic flux, facilitated intracellular redistribution of lc3b, increased average number of autophagosomes per cell, and enhanced development ... | 2017 | 29191621 |
| detection of bacteria colonizing titanium spinal implants in children. | bacterial colonization of spinal implants may cause severe complications in patients with early-onset scoliosis. correct diagnosis and detection of microbiologic formation is crucial to prevent delayed infections caused by bacterial colonization. the purposes of this study were to estimate the rate and risk factors of colonization of vertical expandable prosthetic titanium rib (veptr) implants in children and to compare the different methods for detecting microbiologic formation on the spinal im ... | 2018 | 29190173 |
| bacterial colonisation of suture material after routine neurosurgical procedures: relevance for wound infection. | wound healing impairment is a serious problem in surgical disciplines which may be associated with chronic morbidity, increased cost and patient discomfort. here we aimed to investigate the relevance of bacterial colonisation on suture material using polymerase chain reaction (pcr) to detect and taxonomically classify bacterial dna in patients with and without wound healing problems after routine neurosurgical procedures. | 2018 | 29189910 |
| microbiology alloplastic total joint infections: a 20-year retrospective study. | prosthetic joint infection (pji) is a rare complication of temporomandibular joint replacement (tjr). this study evaluated tjr pjis at the authors' institution over a 20-year period, including micro-organisms cultured, antibiotic resistance patterns, and intraoperative protocols of tjr. | 2018 | 29178982 |
| diversity of bacterial communities on the facial skin of different age-group thai males. | skin microbiome varies from person to person due to a combination of various factors, including age, biogeography, sex, cosmetics and genetics. many skin disorders appear to be related to the resident microflora, yet databases of facial skin microbiome of many biogeographies, including thai, are limited. | 2017 | 29177119 |
| developing an in vitro artificial sebum model to study propionibacterium acnes biofilms. | the aim of the present study was to develop a new model system to study propionibacterium acnes biofilms. this model should be representative for the conditions encountered in the pilosebaceous unit. | 2017 | 29175428 |
| perioperative antibiotic prophylaxis has no effect on time to positivity and proportion of positive samples: a cohort study of 64 cutibacterium acnes bone and joint infections. | if a bone or joint infection is suspected, perioperative antibiotic prophylaxis is frequently withheld until intraoperative microbiological sampling has been performed. this practice builds upon the hypothesis that perioperative antibiotics could render culture results negative and thus impede tailored antibiotic treatment of infections. we aimed to assess the influence of antibiotic prophylaxis within 30 to 60 min before surgery on time to positivity of microbiological samples and on proportion ... | 2018 | 29167293 |
| decrease in diversity of propionibacterium acnes phylotypes in patients with severe acne on the back. | propionibacterium acnes, a major member of normal skin microbiota, is subdivided into 6 phylotypes: ia1, ia2, ib, ic, ii and iii. this study investigated p. acnes subgroups on the face and back in patients with severe acne and in healthy controls. in 71.4% of patients with severe acne, p. acnes phylotypes were identical on the face and back, whereas this was the case in only 45.5% of healthy controls. the healthy group carried phylotypes ia1 (39.1%) and ii (43.4%), whereas the acne group carried ... | 2018 | 29136261 |
| corrigendum: proposal to reclassify propionibacterium acnes type i as propionibacterium acnes subsp. acnes subsp. nov. and propionibacterium acnes type ii as propionibacterium acnes subsp. defendens subsp. nov. | | 2017 | 29130432 |
| cutibacterium (formerly propionibacterium) acnes infections associated with implantable devices. | cutibacterium acnes (c. acnes), a gram-positive biofilm-forming rod implicated in acne vulgaris, is increasingly recognized for its role in implant-associated infections. the diagnosis of c. acnes implant-associated infections remains challenging. the optimal treatment is a combination of both surgical intervention and antibiotic therapy. areas covered: in this review, we discuss the different types of implant-associated infections caused by c. acnes. we also highlight the clinical manifestation ... | 2017 | 29125405 |
| immunohistochemical detection of propionibacterium acnes in the retinal granulomas in patients with ocular sarcoidosis. | the etiology of sarcoidosis is still obscure; however, mycobacteria and propionibacterium acnes are considered the most implicated etiological agent for sarcoidosis. to investigate whether p. acnes is an etiological agent for sarcoid uveitis, we analyzed the frequency of p. acnes detected within the biopsied retinas from patients with ocular sarcoidosis by immunohistochemistry with a p. acnes-specific monoclonal antibody (pab antibody). eleven patients (12 eyes) with sarcoid uveitis were enrolle ... | 2017 | 29123243 |
| identification of low oxygen-tolerating bacteria in prostate secretions of cancer patients and discussion of possible aetiological significance. | the microaerophylic organism propionibacterium acnes has shown consistent association with prostate cancer (pc). studies linking circumcision with reduced pc further support anaerobes involvement as circumcision reduces anaerobe colonisation on the glans penis. a 1988 study linked anaerobes with pc but considered them as opportunists in necrotic tumour. a hypothesis that a "helicobacter-like" process causes pc justified this pilot study. active surveillance patients were enrolled. post-prostate ... | 2017 | 29123122 |
| the antimicrobial effect of cen1hc-br against propionibacterium acnes and its therapeutic and anti-inflammatory effects on acne vulgaris. | propionibacterium acnes is a commensal bacterium, which is involved in acne inflammation. an antimicrobial peptide named cen1hc-br, which was isolated and characterized form the green sea urchin, has been shown to possess broad-spectrum antibacterial activity. little is known concerning the potential effects of its antibacterial and anti-inflammatory properties against p. acnes. to examine the potency of cen1hc-br in acne treatment, we conducted experiments to analyze the antibacterial and anti- ... | 2018 | 29108811 |
| in-vitro evaluation of marine derived fungi against cutibacterium acnes. | cutibacterium acnes (or propionibacterium acnes) is the main target for the prevention and medical treatment of acne vulgaris. the aim of this study was to evaluate the in vitro anti-c. acnes and anti-s. epidermidis properties of some marine fungi isolated from different indian marine environments. seventy fungal isolates were obtained from samples collected from the west coasts and andaman island, india. methanol extracts of 35 isolates were screened for their antibacterial properties and 5 out ... | 2017 | 29100929 |
| low-level red led light inhibits hyperkeratinization and inflammation induced by unsaturated fatty acid in an in vitro model mimicking acne. | acne vulgaris is a chronic inflammatory disease of the pilosebaceous units (psu), associated with increased sebum production, abnormal follicular keratinization (hyperkeratinization), follicular overgrowth of propionibacterium acnes (p. acnes), and increased inflammatory mediator release. light therapy has attracted medical interests as a safe alternative treatment for acne. both blue and red light therapies at high doses >10 j/cm2have demonstrated marked effects on inflammatory acne lesions. ho ... | 2017 | 29095531 |
| detection of clinical cutibacterium acnes isolates in different becton dickinson blood culture vials. | | 2018 | 29093107 |
| association between chronic inflammation and latent infection of propionibacterium acnes in non-pyogenic degenerated intervertebral discs: a pilot study. | propionibacterium acnes may be considered a new pathogeny for disc degeneration, but its pathological role has remained unclear. this study was designed to determine whether the latent infection of p. acnes was associated with chronic inflammation in degenerated intervertebral discs via quantification of the levels of a series of cytokines and neutrophils. | 2017 | 29086028 |
| [diet in pathogenesis of acne vulgaris]. | acne vulgaris is one of the most common dermatologic condition especially among adolescents. acne is related to excess sebum production by sebaceous glands, inflammation both within and adjacent to the comedones, hyperproliferation of propionibacterium acnes. some of investigations show association between acne and diet. milk increases the level of igf-1 leading to the synthesis of androgen-mediated increases sebum production. chocolate predispose to hyperglycemia and insulinemia which aggravate ... | 2017 | 29084194 |
| antibacterial activity of gold nanorods againststaphylococcus aureusandpropionibacterium acnes: misinterpretations and artifacts. | the antibacterial activity of gold nanorod (gnr) suspensions of different surface functionalities was investigated against standard strains ofstaphylococcus aureusandpropionibacterium acnes, taking into consideration two commonly "overlooked" factors: the colloidal stability of gnr suspensions upon mixing with bacterial growth media and the possible contribution of "impurities/molecules" in gnr suspensions to the observed antibacterial activity. the results demonstrated that cationic polyallylam ... | 2017 | 29070948 |
| medicinal mascarene aloes: an audit of their phytotherapeutic potential. | a phytochemical and biological investigation of the endemic mascarene aloes (aloe spp.), including a. tormentorii (marais) l.e.newton & g.d.rowley, a. purpurea lam, a. macra haw., a. lomatophylloides balf.f and a. vera (synonym a. barbadensis mill.), which are used in the traditional folk medicine of the mascarene islands, was initiated. methanolic extracts of the aloes under study were analysed using high resolution lc-uv-ms/ms and compounds belonging to the class of anthraquinones, anthrones, ... | 2018 | 29066297 |
| targeted sequencing of clade-specific markers from skin microbiomes for forensic human identification. | the human skin microbiome is comprised of diverse communities of bacterial, eukaryotic, and viral taxa and contributes millions of additional genes to the repertoire of human genes, affecting human metabolism and immune response. numerous genetic and environmental factors influence the microbiome composition and as such contribute to individual-specific microbial signatures which may be exploited for forensic applications. previous studies have demonstrated the potential to associate skin microb ... | 2018 | 29065388 |
| computed tomography fistulography of the sternum. a case report on interprofessional collaboration between radiologist and surgeon. | trans sternal fistula can occur after sternotomy/heart surgery. diagnosing this can be difficult. | 2017 | 29055879 |
| draft genome sequences of three multidrug-resistant cutibacterium (formerly propionibacterium) acnes strains isolated from acne patients, china. | cutibacterium acnes (formerly propionibacterium acnes), an anaerobic gram-positive bacterium, is a skin commensal and is considered to be associated with acne. here we report the draft genome sequences of three multidrug-resistant (mdr) c. acnes strains (ca17, ca39 and ca51) isolated from skin lesions of acne patients in china. | 2017 | 29051020 |
| performance of implant sonication culture for the diagnosis of periprosthetic shoulder infection. | diagnosing infection after shoulder arthroplasty can be a challenge because of the high prevalence of low-virulence organisms, such as propionibacterium acnes. the purpose of this study was to evaluate the utility of implant sonication fluid cultures in the diagnosis of periprosthetic joint infection compared with standard culture techniques in patients undergoing revision shoulder arthroplasty. | 2018 | 29037535 |
| [persistent extra-axial post-surgical collections and propionibacterium acnes infection. presentation of two cases and literature review]. | it is common to observe the persistence of extra-axial collections after craniotomies. most of these disappear in weeks or months but some remain. the onset of focal symptoms or the growth of these persistent collections months or years after surgery may indicate the presence of a chronic and latent infection by germs of low virulence such as propionibacterium acnes (p. acnes). | 2017 | 29033263 |
| colonization of oropharynx and lower respiratory tract in critical patients: risk of ventilator-associated pneumonia. | to investigate the microbial diversity existing in oral cavity and respiratory tract samples (from mini-bronchoalveolar lavage (bal), endotracheal aspirate, and orotracheal tube) of patients on mechanical ventilation by using the checkerboard dna-dna hybridisation. also, the study aimed to evaluate whether the microbial profile in the oral cavity is found in respiratory tract samples, at different periods of mechanical ventilation time (12h, 48h, 96h) in attempt to identification of relationship ... | 2018 | 29031240 |
| targeted intervention of acute postoperative infection after rotator cuff repair results in good functional outcomes. | the primary goal of this retrospective review of a prospective database was to document the functional results after acute postoperative deep infection following rotator cuff repair in a single orthopaedic unit over a period of 5 years. secondary goals were to document the effect of infection on healing of the cuff repair and to describe its incidence, diagnostic challenges, pathogens and management. | 2018 | 29022059 |
| constrictive pericarditis caused by cutibacterium (propionibacterium) acnes: a case report and review of literature. | constrictive and effusive-constrictive pericarditis are rare cardiac disorders. only rarely are the conditions caused by purulent infection, and even more infrequently by anaerobe bacteria. we describe a case of constrictive - and effusive-constrictive pericarditis due tocutibacterium (formerlypropionibacterium) acnesin a 75-year old, immunocompetent and previously healthy patient without any predisposition. the patient was successfully treated with subtotal pericardiectomy and beta-lactam antib ... | 2017 | 29021959 |
| propionibacterium avidum: a virulent pathogen causing hip periprosthetic joint infection. | propionibacteria are important members of the human skin microbiota, but are also opportunistic pathogens associated with periprosthetic joint infection (pji). while the role of propionibacterium acnes in pji has been widely described, insight into the capacity of propionibacterium avidum to cause pji is limited. | 2018 | 29020266 |
| propionibacterium acnes as an emerging pathogen in skull base osteomyelitis: a case series. | skull base osteomyelitis (sbo) is recognized as a potentially life-threatening infection that has been classically attributed to pseudomonas aeruginosa. however, growing data shows that the bacteriology of sbo is changing. traditionally thought of as commensal bacterium, p. acnes has been implicated as a serious pathogen in other specialties. building on a previous case report from our institution, we have identified three patients with sbo who are culture-positive for propionibacterium acnes as ... | 2018 | 28994125 |
| in vitroactivities of pexiganan and 10 comparator antimicrobials against 502 anaerobic isolates recovered from skin and skin structure infections. | pexiganan, a cationic peptide, exhibited a broad range of anti-anaerobic antimicrobial activity. the mic90s of studied isolates were as follows:bacteroides fragilis, 16 μg/ml; otherb. fragilisgroup spp., 4 μg/ml;prevotellaandfusobacteriumspp., 32 μg/ml;porphyromonasspp., 64 μg/ml;propionibacterium acnes, 4 μg/ml;eggerthella lentaandpeptostreptococcus anaerobius, 32 μg/ml; other gram-positive rods and cocci, 4 μg/ml;clostridium perfringens, 128 μg/ml; and other clostridia, 256 μg/ml. pexiganan cr ... | 2017 | 28993327 |