| pacemaker endocarditis caused by propionibacterium acnes: a case report. | a 74-year-old man, with a permanent pacemaker placed 2 years ago for high-grade atrioventricular block, was admitted for worsening fatigue, confusion, and thrombocytopenic purpura without fever. white blood cell count and c-reactive protein were elevated, and echocardiography revealed a 6 × 3-cm echogenic mass surrounding the pacemaker leads. multiple blood cultures were performed, and only 1 bottle grew propionibacterium acnes at 93 hours. the patient underwent surgery, and 16s rrna gene polyme ... | 2012 | 22652170 |
| what's new in antibiotics in the management of acne? | acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit with a multifactorial pathogenesis. topical and oral antibiotics are a mainstay treatment for inflammatory acne lesions and are widely utilized for all levels of disease severity. over the past forty years, a gradual increase in antibacterial-resistant strains of propionibacterium acnes has changed the way practitioners use antibiotics to manage acne. updated recommendations call for avoiding antibiotic monotherapy and pre ... | 2012 | 22648324 |
| draft genome sequence of an antibiotic-resistant propionibacterium acnes strain, prp-38, from the novel type ic cluster. | propionibacterium acnes, a non-spore-forming, anaerobic gram-positive bacterium, is most notably recognized for its association with acne vulgaris (i. kurokawa et al., exp. dermatol. 18:821-832, 2009). we now present the draft genome sequence of an antibiotic-resistant p. acnes strain, prp-38, isolated from an acne patient in the united kingdom and belonging to the novel type ic cluster. | 2012 | 22628495 |
| anti propionibacterium acnes activity of rhodomyrtone, an effective compound from rhodomyrtus tomentosa (aiton) hassk. leaves. | propionibacterium acnes have been recognized as one of the main causative agents in pathogenesis of acne. twenty one isolates of p. acnes isolated from acne lesions were screened for lipase and protease activity which are reported to be associated in acne and inflammation. interestingly, all p. acnes isolates demonstrated lipase activity. similarly, 90% of test p. acnes produced protease enzyme. antibacterial activity of the ethanol extract of rhodomyrtus tomentosa (aiton) hassk. leaves and rhod ... | 2012 | 22626672 |
| multilocus sequence typing and repetitive-sequence-based pcr (diversilab) for molecular epidemiological characterization of propionibacterium acnes isolates of heterogeneous origin. | propionibacterium acnes is a gram-positive bacillus predominantly found on the skin. although it is considered an opportunistic pathogen it is also been associated with severe infections. some specific p. acnes subtypes are hypothesized to be more prone to cause infection than others. thus, the aim of the present study was to investigate the ability to discriminate between p. acnes isolates of a refined multilocus sequence typing (mlst) method and a genotyping method, diversilab, based on repeti ... | 2012 | 22609518 |
| localization of propionibacterium acnes in granulomas supports a possible etiologic link between sarcoidosis and the bacterium. | sarcoidosis likely results from the exposure of a genetically susceptible subject to an environmental agent, possibly an infectious one. mycobacterial and propionibacterial organisms are the most commonly implicated potential etiologic agents. propionibacterium acnes is the only microorganism, however, found in sarcoid lesions by bacterial culture. to evaluate the pathogenic role of this indigenous bacterium, we screened for the bacterium in sarcoid and non-sarcoid tissues using immunohistochemi ... | 2012 | 22596102 |
| syk/src pathway-targeted inhibition of skin inflammatory responses by carnosic acid. | carnosic acid (ca) is a diterpene compound exhibiting antioxidative, anticancer, anti-angiogenic, anti-inflammatory, anti-metabolic disorder, and hepatoprotective and neuroprotective activities. in this study, the effect of ca on various skin inflammatory responses and its inhibitory mechanism were examined. ca strongly suppressed the production of il-6, il-8, and mcp-1 from keratinocyte hacat cells stimulated with sodium lauryl sulfate (sls) and retinoic acid (ra). in addition, ca blocked the r ... | 2012 | 22577255 |
| propionibacterium acnes (p. acnes) resistance and antibiotic use in patients attending australian general practice. | antibiotic resistance in the community, including transfer between bacteria, is a growing concern for clinicians. acne is commonly treated in general practice, sometimes with antibiotics. the aim of this study is to measure the rate of carriage of antibiotic resistant propionibacterium acnes 10 years apart in general practice and the relationship of resistance to type of treatment, as well potential effects on other flora. | 2012 | 22571557 |
| dual analysis for mycobacteria and propionibacteria in sarcoidosis bal. | sarcoidosis is a non-caseating granulomatous disease for which a role for infectious antigens continues to strengthen. recent studies have reported molecular evidence of mycobacteria or propionibacteria. we assessed for immune responses against mycobacterial and propionibacterial antigens in sarcoidosis bronchoalveolar lavage (bal) using flow cytometry, and localized signals consistent with microbial antigens with sarcoidosis specimens, using matrix-assisted laser desorption ionization imaging m ... | 2012 | 22552860 |
| de novo synthesis of trans-10, cis-12 conjugated linoleic acid in oleaginous yeast yarrowia lipolytica. | conjugated linoleic acid (cla) has many well-documented beneficial physiological effects. due to the insufficient natural supply of cla and low specificity of chemically produced cla, an effective and isomer-specific production process is required for medicinal and nutritional purposes. | 2012 | 22545818 |
| periprosthetic infections after total shoulder arthroplasty: a 33-year perspective. | to examine the rates and predictors of deep periprosthetic infections after primary total shoulder arthroplasty (tsa). | 2012 | 22516570 |
| systemic isotretinoin therapy normalizes exaggerated tlr-2-mediated innate immune responses in acne patients. | retinoids are used in the treatment of inflammatory skin diseases and malignancies, but studies characterizing the in vivo actions of these drugs in humans are lacking. isotretinoin is a pro-drug for all-trans retinoic acid, which can induce long-term remissions of acne; however, its complete mechanism of action is unknown. we hypothesized that isotretinoin induces remission of acne by normalizing the innate immune response to the commensal bacterium propionibacterium acnes. compared with normal ... | 2012 | 22513780 |
| pattern of tissue invasion by propionibacterium acnes in acne vulgaris. | | 2012 | 22510385 |
| microbial spectrum and resistance patterns in endophthalmitis: a 21-year (1988-2008) review in northeast united states. | to study the microbial spectrum and antibacterial susceptibility of vitreous cultures in a tertiary referral center in northeast united states. | 2012 | 22506856 |
| crispr/cas loci of type ii propionibacterium acnes confer immunity against acquisition of mobile elements present in type i p. acnes. | propionibacterium acnes is a skin commensal that occasionally acts as an opportunistic pathogen. the population structure of this species shows three main lineages (i-iii). while type i strains are mainly associated with sebaceous follicles of human skin and inflammatory acne, types ii and iii strains are more often associated with deep tissue infections. we investigated the occurrence and distribution of the clustered regularly interspaced short palindromic repeats (crispr) in p. acnes, assesse ... | 2012 | 22479553 |
| generation and characterization of chicken egg yolk antibodies against propionibacterium acnes for the prevention of acne vulgaris. | antigen-specific antibody has been widely used for immunological analysis in the field of diagnosis as well as in pure scientific research, where the igy antibodies can be raised against p acnes antigen. | 2012 | 22470202 |
| acne sans p. acnes. | acne vulgaris is a common disease that carries an enormous financial and psychosocial impact. androgens, excessive sebum production, ductal hypercornification, changes in the microbial flora, as well as inflammation and immunological host reactions are considered the major contributors to acne pathogenesis. despite extensive research on acne pathogenesis, the exact sequence of events and their possible mechanisms leading to the development of a microcomedone and its transformation into an inflam ... | 2013 | 22458782 |
| adjuvant effect of killed propionibacterium acnes on mouse peritoneal b-1 lymphocytes and their early phagocyte differentiation. | b-1 lymphocytes are the predominant cells in mouse peritoneal cavity. they express macrophage and lymphocyte markers and are divided into b-1a, b-1b and b-1c subtypes. the role of b-1 cells is not completely clear, but they are responsible for natural igm production and seem to play a regulatory role. an enriched b-1b cell population can be obtained from non-adherent peritoneal cell cultures, and we have previously demonstrated that these cells undergo differentiation to acquire a mononuclear ph ... | 2012 | 22448280 |
| propionibacterium acnes delayed infection following spinal surgery with instrumentation. | propionibacterium acnes detection in culture media was previously considered a contamination but recently its infectious role was discovered in post-spinal surgery infections. p. acnes might be introduced during surgery. its diagnosis is based on non-specific clinical signs, image indications of infection, and the conclusive microbiological sign. furthermore, its diagnosis is difficult because of slow growth rate and low virulence, delaying its presentation. usually, the infection is manifested ... | 2013 | 22441672 |
| efficacy of surgical preparation solutions in lumbar spine surgery. | postoperative spinal wound infections are relatively common and are often associated with increased morbidity and poor long-term patient outcomes. the purposes of this study were to identify the common bacterial flora on the skin overlying the lumbar spine and evaluate the efficacy of readily available skin-preparation solutions in the elimination of bacterial pathogens from the surgical site following skin preparation. | 2012 | 22437997 |
| cardiovascular implantable electronic device endocarditis treated with daptomycin with or without transvenous removal. | nine patients with cardiovascular implantable electronic device (cied) endocarditis were treated with daptomycin after the failure of previous treatment. the blood and cied lead cultures of 1 patient were negative. in the other 8 patients, we observed 6 monomicrobic infections and 2 polymicrobic infections. overall, 10 strains were isolated in these patients: 4 methicillin-sensitive staphylococcus aureus, 2 methicillin-sensitive staphylococcus epidermidis, 1 methicillin-resistant staphylococcus ... | 2013 | 22436967 |
| propionibacterium acnes brain abscess in a patient with hiv-1 infection. | | 2012 | 22403028 |
| optimizing topical combination therapy for the treatment of acne vulgaris. | given the multifactorial and complex contributors to acne development, combination therapy is standard of care. by addressing multiple pathogenic factors, combination therapy provides a quicker and more efficacious treatment outcome than monotherapy. topical retinoids normalize follicular keratinocyte differentiation and are anti-inflammatory. their use is limited by the potential for cutaneous irritation. antimicrobials reduce propionibacterium acnes colonization on the skin and reduce the bact ... | 2012 | 22395581 |
| novel anti-acne actions of nadifloxacin and clindamycin that inhibit the production of sebum, prostaglandin e(2) and promatrix metalloproteinase-2 in hamster sebocytes. | acne vulgaris is characteristic of excess sebum production and the induction of inflammatory reactions, for example, the augmentation of cytokine, prostaglandin (pg) and matrix metalloproteinase (mmp) production in sebaceous glands and pilosebaceous units. as propionibacterium acnes is considered to be involved in the aggravation of acne vulgaris, antimicrobial agents have been found to be effective for treating acne leading to the remission of inflammation. however, it is not fully understood w ... | 2012 | 22394009 |
| complete genome sequences of three propionibacterium acnes isolates from the type ia(2) cluster. | propionibacterium acnes is an anaerobic gram-positive bacterium that has been linked to a wide range of opportunistic human infections and conditions, most notably acne vulgaris (i. kurokawa et al., exp. dermatol. 18:821-832, 2009). we now present the whole-genome sequences of three p. acnes strains from the type ia(2) cluster which were recovered from ophthalmic infections (a. mcdowell et al., microbiology 157:1990-2003, 2011). | 2012 | 22374954 |
| peptides with antimicrobial and anti-inflammatory activities that have therapeutic potential for treatment of acne vulgaris. | the pathogenesis of acne vulgaris is multifactorial involving infection of the pilosebaceous unit with propionibacterium acnes and a cytokine-mediated inflammatory response. five frog skin-derived antimicrobial peptides ([d4k]ascaphin-8, [g4k]xt-7, [t5k]temporin-dra, brevinin-2gu, and b2rp-era), chosen for their low hemolytic activity against human erythrocytes, were assessed for their effects on the growth of clinical isolates of p. acnes and on the release of pro-inflammatory and anti-inflamma ... | 2012 | 22374306 |
| effect of lactobacillus reuteri on the proliferation of propionibacterium acnes and staphylococcus epidermidis. | while it is generally accepted that propionibacterium acnes is involved in the development of acne, other bacteria including staphylococcus epidermidis have also been isolated from the acne lesion. the interaction between lactobacillus reuteri, a probiotic bacterium, and acnegenic bacteria is unclear. this study examined the effects of l. reuteri on the proliferation of p. acnes and s. epidermidis. human-derived l. reuteri strains (kctc 3594 and kctc 3678) and rat-derived l. reuteri kctc 3679 we ... | 2012 | 22367948 |
| effects of 420-nm intense pulsed light in an acne animal model. | blue light in the 400-420 nm range has been shown to reduce the levels of propionibacterium acnes (p. acnes) in the skin. p. acnes has been postulated to be a critical trigger for inflammatory acne. thus, treatment with 420 nm-intense pulsed light should reduce inflammatory activity in acne. | 2013 | 22364124 |
| an increased incidence of propionibacterium acnes biofilms in acne vulgaris: a case-control study. | acne vulgaris is a disorder of the sebaceous follicles. propionibacterium acnes can be involved in inflammatory acne. | 2012 | 22356121 |
| reinfection rates after 1-stage revision shoulder arthroplasty for patients with unexpected positive intraoperative cultures. | recent studies have detailed the significance of indolent infections in revision shoulder arthroplasty, but little information is available to guide treatment strategies regarding patients with positive cultures without overt signs of infection. the primary purpose of this study was to determine recurrence rates of infection for patients undergoing revision shoulder arthroplasty who were not treated for infection but had positive intraoperative cultures. | 2012 | 22305921 |
| eradication of propionibacterium acnes biofilms by plant extracts and putative identification of icariin, resveratrol and salidroside as active compounds. | propionibacterium acnes is a gram-positive bacterium that plays an important role in the pathogenesis of acne vulgaris. this organism is capable of biofilm formation and the decreased antimicrobial susceptibility of biofilm-associated cells may hamper efficient treatment. in addition, the prolonged use of systemic antibiotic therapy is likely to lead to the development and spread of antimicrobial resistance. in the present study we investigated whether p. acnes biofilms could be eradicated by pl ... | 2012 | 22305279 |
| inhibition of propionibacterium acnes lipase by extracts of indian medicinal plants. | lipases play an important role in pathogenesis of acne by hydrolysing sebum triglycerides and releasing irritating free fatty acids in the pilosebaceous follicles. lipase is a strong chemotactic and proinflammatory antigen. therefore, lipase has generated a high interest as a pharmacological target for antiacne drugs. the aim of this study was to identify inhibitory effects of plant extracts on the lipase activity of propionibacterium acnes. colorimetric microassay was used to determine lipase a ... | 2012 | 22268921 |
| the polysaccharide fraction of propionibacterium acnes modulates the development of experimental focal segmental glomerulosclerosis. | the pathogenesis of focal segmental glomerulosclerosis (fsgs) appears to be associated with type-2 cytokines and podocyte dysfunction. in this study, we tested the hypothesis that immunization with the polysaccharide fraction of propionibacterium acnes (ps), a pro-th1 agonist, may subvert the type-2 profile and protect podocytes from adriamycin-induced glomerulosclerosis. adriamycin injection resulted in albuminuria and increased serum creatinine in association with loss of glomerular podocin an ... | 2012 | 22257707 |
| genetic diversity of propionibacterium acnes strains isolated from human skin in japan and comparison with their distribution in europe. | propionibacterium acnes, a commensal of human skin, is also an opportunistic pathogen of common acne and certain infectious diseases. however, it is still not obvious which strain is pathogenic for a certain infectious disease, and investigations to characterize pathogenic strains using molecular typing methods such as mlst using several housekeeping genes have been undertaken. however, to date, such analysis has focused mainly on strains isolated from europeans, and it is unclear whether the cl ... | 2012 | 22245790 |
| follicular spicules associated with propionibacterium acnes with response to erythromycin: lack of evidence for the species? | | 2012 | 22224953 |
| a quantitative analysis of propionibacterium acnes in lesional and non-lesional skin of patients with progressive macular hypomelanosis by real-time polymerase chain reaction. | little is known about the etiology of progressive macular hypomelanosis, although it has been suggested that propionibacterium acnes plays an important role. while microbiological culture is commonly employed to identify propionibacterium acnes, new identification methods have been under investigation, amongst them polymerase chain reaction. to determine the cut-off point for the number of genome copies of propionibacterium acnes in the lesional skin of patients with progressive macular hypomela ... | 2011 | 24031649 |
| propionibacterium acnes pyogenic liver abscess and pylephlebitis. | reported is an unusual case of pyogenic liver abscess and septic thrombophlebitis of the portal vein in a 44-year-old male caused by propionibacterium acnes successfully managed with a combination of percutaneous drainage and antimicrobial therapy. to the best of our knowledge, this is the first report of this bacterium isolated in pure culture as the sole etiologic organism of pyogenic liver abscess and pylephlebitis in an adult patient. | 2011 | 25954544 |
| pathogen characteristics and its sensitivity against antimicrobial agents in fatal bacterial granuloma after eyelid trauma in vitro. | to understand the pathogen characteristics and its sensitivity against antimicrobial agents in fatal bacterial granuloma after eyelid trauma (fbgt) in vitro, and to provide laboratory evidence for diagnosis. | 2011 | 22553692 |
| primary intraocular lymphoma: another great masquerader. | to describe diverse and atypical presentations of the most common masquerader in neoplastic masquerade syndromes. | 2017 | 28221644 |
| late onset posttraumatic propionibacterium acnes endophthalmitis. | to report a case of late onset posttraumatic endophthalmitis secondary to propionibacterium acnes infection. | 2017 | 28221490 |
| interleukin-18. | interleukin-18 (il-18), a recently described member of the il-1 cytokine superfamily, is now recognized as an important regulator of innate and acquired immune responses. il-18 is expressed at sites of chronic inflammation, in autoimmune diseases, in a variety of cancers, and in the context of numerous infectious diseases. this short review will describe the basic biology of il-18 and thereafter address its potential effector and regulatory role in several human disease states including autoimmu ... | 2003 | 12554798 |
| propionibacterium acnes endophthalmitis in ahmed glaucoma valve. | to report a case of propionibacterium acnes endophthalmitis in a patient with an ahmed glaucoma valve. | 2017 | 28226111 |
| hepatoprotective effects of panax notoginseng: ginsenosides -re and -rg(1) as its active constituents in d-galactosamine/lipopolysaccharide-induced liver injury. | the hepatoprotective effects of the methanol and water extracts of the roots of panax notoginseng were studied on various animal models. the methanol and water extracts of p. notoginseng showed a significant activity in carbon tetrachloride-induced liver injury in rats. however, the methanol extract was found to be more active. the hepatoprotective effects of the methanol extract was further evaluated using d-galactosamine as well as heat-killed propionibacterium acnes/lipopolysaccharide-induced ... | 1996 | 23194765 |
| clinical pathologic findings of propionibacterium acnes endophthalmitis. | the autors presented two typical cases of patients who were infected with propionibacterium acnes (p. acnes) after intraocular lens implantation. the patients were treated successfully by the removal of the intraocular lens and the residual lens capsule, and the administration of intravitreal vacomycin. the histopathology illustrated numerous prokaryote bacilli surrounding the lens material without inflammatory reaction. the thickened bacterial cell wall structure may relate to the resistance of ... | 1996 | 22827335 |
| association of propionibacterium acnes endophthalmitis with hla-dqw5. | an hla-dq1 association has been suspected in patients who develop propionibacterium acnes endophthalmitis following cataract surgery. new techniques exist which may help to define this association. | 1996 | 22827330 |
| [antibiotic prophylaxis in open fractures]. | the administration of antibiotics is now generally accepted as a prophylactic treatment of infection in compound fractures. nevertheless the question is not completely resolved and many problems are still to be discussed.the efficacy of antibiotherapy in this field has just been recently demonstrated ; with the animals by worlock et al. (1988) using an experimental rabbit model, and clinically by braul et al. (1987) which randomized 87 patients with open fractures to receive either cloxacillin o ... | 1995 | 24193267 |
| volatile ketones from interdigital glands of black-tailed deer,odocileus hemionus columbianus. | three volatile ketones, 2-tridecanone, (e)-3-tridecen-2-one and (e)-4-tridecen-2-one were identified in interdigital gland extracts from black-tailed deer,odocoileus hemionus columbianus. the major compound, (e)-3-tridecen-2-one, inhibited the growth of several species of fungi and grampositive bacteria. the bacterium,propionibacterium acnes, and the fungus,trichophyton mentagrophytes required a minimum concentration (mic) of 12.5 µg/ml and 25 µg/ml, respectively, for inhibition, (e)-3-tridecen- ... | 1995 | 24233672 |
| clinicobacteriological study of acne vulgaris. | the aetiological relationship propionibacterium acnes in acne vulgaris has been suggested. a clinicobacteriological study in 45 patients suffering from acne vulgaris was conducted for the first time in indian patients. p acnes could be isolated from 18 (40.0%) and other propionibacterium species from 9 (20.0%) of the 45 patients studied. no correlation of culture positivity with the sex of the patient or duration and grade of the disease could be established, p acnes antibodies were, tested for ... | 2017 | 28223653 |
| mikania glomerata sprengel extract and its major compound ent-kaurenoic acid display activity against bacteria present in endodontic infections. | the search for new, effective and safe antimicrobial compounds from plant sources has continued to play an important role in the maintenance of human health since ancient times. such compounds can be used to help to eradicate microorganisms from the root canal system, preventing/healing periapical diseases. mikania glomerata (spreng.), commonly known as "guaco," is a native climbing plant from brazil that displays a wide range of pharmacological properties. many of its activities have been attri ... | 2017 | 28627377 |
| b cell cross-epitope of propionibacterium acnes and actinobacillus pleuropneumonia selected by phage display library can efficiently protect from actinobacillus pleuropneumonia infection. | contagious porcine pleuropneumonia (cpp), caused by actinobacillus pleuropneumoniae (app), is a highly transmissible and fatal respiratory illness that causes tremendous economic losses for the pig breeding industry worldwide. propionibacterium acnes (pa) has a strong cross-reaction with anti-app1 and anti-app5 serum and can efficiently prevent app infection, which was fortuitously found in researching the differential gene between the different app serotypes. there seems to be some natural cros ... | 2017 | 28622855 |
| anaerobic bacteria growth in the presence of cathelicidin ll-37 and selected ceragenins delivered as magnetic nanoparticles cargo. | cationic antibacterial peptides (caps) and synthetic molecules mimicking the amphiphilic structure of caps, such as ceragenins, are promising compounds for the development of new antimicrobials. | 2017 | 28747178 |
| [effect of silver nanoparticles on anaerobic bacteria]. | the aim was to evaluate the antibacterial effect of silver nanoparticles on anaerobic bacteria. | 2017 | 28467592 |
| comparative antimicrobial efficacy of selected root canal irrigants on commonly isolated microorganisms in endodontic infection. | this study aims to evaluate and compare the antimicrobial efficacy of three selected root canal irrigants (biopure mtad, metronidazole, aztreonam) against microbes commonly isolated from polymicrobial microbiota of root canal infection. | 2017 | 28435359 |
| identification and characterization of multifunctional cationic and amphipathic peptides from soybean proteins. | in this study, we identified and chemically synthesized three cationic and amphipathic peptides (glycinin-17, bcas-16, and bcbs-11) from soybean proteins. these peptides had high isoelectric points, high positive net charges, and included multiple hydrophobic amino acids. subsequently, we identified multiple functions of these peptides, including antimicrobial, lipopolysaccharide-neutralizing, and angiogenic activities, and examined their cytotoxic activities against mammalian red blood cells. g ... | 2017 | 28459130 |
| propionibacterium acnes-associated neurosarcoidosis: a case report with review of the literature. | a 56-year-old woman with a 3-year history of hydrocephalus and ventriculo-peritoneal shunt placement, presented with worsening altered level of consciousness for 2 days. imaging studies showed severe ventriculomegaly involving the lateral and third ventricles with multiple septated cysts noted in the lateral ventricles predominantly near the frontal horns. histopathologic examination of the excised brain lesion revealed choroid plexus tissue and adjacent cerebral parenchyma with several non-case ... | 2017 | 28856748 |
| whole-body microbiota of sea cucumber (apostichopus japonicus) from south korea for improved seafood management. | sea cucumber (apostichopus japonicus) is a popular seafood source in asia, including south korea, and its consumption has recently increased with recognition of its medicinal properties. however, because raw sea cucumber contains various microbes, its ingestion can cause foodborne illness. therefore, analysis of the microbiota in the whole body of sea cucumber can extend our understanding of foodborne illness caused by microorganisms and help to better manage products. we collected 40 sea cucumb ... | 2017 | 28851208 |
| utility of strain typing of propionibacterium acnes in central nervous system and prosthetic joint infections to differentiate contamination from infection: a retrospective cohort. | the study aimed to retrospectively assess if strain typing of propionibacterium acnes could help to distinguish between infection and contamination in isolates recovered from the central nervous system (cns) and prosthetic joints (pjs). this was a retrospective cohort of all propionibacterium species isolates from the barnes-jewish hospital (st louis, mo, usa) clinical microbiology laboratory from 2011 to 2014. available frozen isolates were recovered, and strain type (ia-1, ia-2, ib, ii, iii, o ... | 2017 | 28842758 |
| evaluation of anti-inflammatory and antimicrobial activity of ahpl/aycap/0413 capsule. | conventional therapeutic agents used for treatment of acne are associated with various adverse effects necessitating development of safe and effective alternative therapeutic agents. in this context, a polyherbal formulation ahpl/aycap/0413 was developed for treatment of acne. | 2017 | 28827969 |
| cutibacteriumacnes septic arthritis of the nonoperated knee: a case report. | cutibacterium (propionibacterium) acnes , a gram-positive bacillus with low pathogenicity, is an uncommon but known cause of prosthetic joint infections, particularly related to shoulder surgery. c. acnes , however, is an extremely rare pathogen in the nonoperated knee joint. this report details an uncommon case of c. acnes septic knee arthritis after multiple intra-articular steroid injections in a 56-year-old male patient. after an indolent presentation and late diagnosis, the patient underwen ... | 2017 | 28825032 |
| in vitro anti-acne activity of phytoactives from the stem bark of artocarpus hirsutus lam. and characterisation of pyranocycloartobiloxanthone a as a mixture of two anomers. | this study is aimed to isolate the phytoactives from the stem bark of artocarpus hirsutus and evaluate their in vitro anti-acne activity. the ethanolic stem bark extract of a. hirsutus provided two major phytoactive constituents: (i) pyranocycloartobiloxanthone a, (1) and (ii) artonine e, (2) whose structures were determined by nmr and ms spectroscopic analysis. the present study is the first to report compound 1 as a mixture of two anomers (α and β), approximately 70:30 ratio. both compounds 1 ... | 2017 | 28820275 |
| description of actinokineospora acnipugnans sp. nov., an actinomycete isolated from soil, showing potential uses in cosmetics. | during isolation of soil bacteria having antibacterial functions, an aerobic, gram-stain-positive, oxidase-negative, catalase-positive bacterium, designated strain r434t, was isolated. strain r434t showed antimicrobial activity against propionibacterium acnes and staphylococcus epidermidis and significant enzyme-inhibitory capability. the diagnostic diamino acid of the cell-wall peptidoglycan was meso-diaminopimelic acid, and the whole-cell sugars were galactose, arabinose and glucose. phylogene ... | 2017 | 28820111 |
| what is new in the pathophysiology of acne, an overview. | acne is a chronic inflammatory disease of the pilosebaceous unit. its pathophysiology includes hyperseborrhoea, abnormal follicular keratinization and propionibacterium acnes proliferation in the pilosebaceous unit. recent research has shed some new light on the involvement of the sebaceous gland, as well as on the pro-inflammatory activity of the cutaneous microbiome. during puberty, alteration of the sebaceous lipid profile, called dysseborrhoea, stress, irritation, cosmetics and potential die ... | 2017 | 28805938 |
| sebocytes contribute to skin inflammation by promoting the differentiation of th17 cells. | the main function of sebocytes is considered to be the lipid production for moisturizing the skin. however, it became recently apparent that sebocytes release chemokines and cytokines and respond to pro-inflammatory stimuli as well as presence of bacteria. | 2017 | 28799643 |
| conjunctival bacteria flora of glaucoma patients during long-term administration of prostaglandin analog drops. | to investigate the effects of the long-term use of prostaglandin analogs for glaucoma treatment on the indigenous flora of the conjunctiva. | 2017 | 28796877 |
| propionibacterium acnes and the th1/th17 axis, implications in acne pathogenesis and treatment. | acne vulgaris is one of the most commonly seen conditions and the immunological link is a topic of active research. recently, the th17 pathway has been found to play a pivotal role in acne. the adaptive immune response toward propionibacterium acnes leads to activation of th17 axis. consequently, the th17 cytokines (il-17, il-1 β, il-6, and tumor growth factor, in turn, activate the various pathogenic steps in acne. drugs such as vitamin d3 and isotretinoin which target the th17 pathway may offe ... | 2017 | 28794550 |
| synchronizing pharmacotherapy in acne with review of clinical care. | acne is a chronic inflammatory skin disease that involves the pathogenesis of four major factors, such as androgen-induced increased sebum secretion, altered keratinization, colonization of propionibacterium acnes, and inflammation. several acne mono-treatment and combination treatment regimens are available and prescribed in the indian market, ranging from retinoids, benzoyl peroxide (bpo), anti-infectives, and other miscellaneous agents. although standard guidelines and recommendations overvie ... | 2017 | 28794543 |
| non-antibiotic isotretinoin treatment differentially controls propionibacterium acnes on skin of acne patients. | emergence and potential transfer of antibiotic resistance in skin microorganisms is of current concern in medicine especially in dermatology contexts where long term treatment with antibiotics is common. remarkably, non-antibiotic therapy in the form of isotretinoin - a non-antimicrobial retinoid is effective at reducing or eradicating the anaerobe propionibacterium acnes which is causally involved in the complex pathogenesis of acne vulgaris. this study measured the extent of colonization of p. ... | 2017 | 28790988 |
| inhibition of hdac8 and hdac9 by microbial short-chain fatty acids breaks immune tolerance of the epidermis to tlr ligands. | epidermal keratinocytes participate in immune defense through their capacity to recognize danger, trigger inflammation, and resist infection. however, normal skin immune function must tolerate contact with an abundant community of commensal microbes without inflammation. we hypothesized that microbial environmental conditions dictate the production of molecules that influence epigenetic events and cause keratinocytes to break innate immune tolerance. propionibacterium acnes, a commensal skin bac ... | 2016 | 28783689 |
| antibiotic treatment of propionibacterium acnes endocarditis. | | 2017 | 28782652 |
| fast 2d nmr spectroscopy for in vivo monitoring of bacterial metabolism in complex mixtures. | the biological toolbox is full of techniques developed originally for analytical chemistry. among them, spectroscopic experiments are very important source of atomic-level structural information. nuclear magnetic resonance (nmr) spectroscopy, although very advanced in chemical and biophysical applications, has been used in microbiology only in a limited manner. so far, mostly one-dimensional (1)h experiments have been reported in studies of bacterial metabolism monitored in situ. however, low sp ... | 2017 | 28769889 |
| the colonisation of the glenohumeral joint by propionibacterium acnes is not associated with frozen shoulder but is more likely to occur after an injection into the joint. | our aim was to investigate the prevalence of propionibacterium (p.) acnes in the subcutaneous fat and capsule of patients undergoing shoulder surgery for frozen shoulder or instability. | 2017 | 28768784 |
| two-stage reimplantation for the treatment of deep infection after shoulder arthroplasty. | two-stage reimplantation is the most common treatment modality considered for periprosthetic shoulder infection (psi). most studies to date have reported on a relatively small number of shoulders. the purpose of this study was to determine the outcome of 2-stage reimplantation for psi in terms of both eradication of infection and restoration of function. | 2017 | 28751093 |
| characterization of a propionibacterium acnes surface protein as a fibrinogen-binding protein. | propionibacterium acnes (p. acnes) is a major skin-associated bacterium that was long considered commensal, until several studies revealed it to be an opportunistic pathogen. we investigated the ability of p. acnes surface proteins to recognize ecm proteins and showed that a 58 kda p. acnes surface protein was specifically recognized by human fibrinogen (hfg). the 58 kda protein was further characterized by two-dimensional (2-d) electrophoresis and maldi-tof as a p. acnes host cell-surface attac ... | 2017 | 28743910 |
| preoperative doxycycline does not decolonize propionibacterium acnes from the skin of the shoulder: a randomized controlled trial. | propionibacterium acnes is frequently cultured in patients undergoing both primary and revision shoulder surgery. the purpose of this study was to evaluate the efficacy and safety of preoperative oral administration of doxycycline in decreasing the colonization of skin around the shoulder by p. acnes. | 2017 | 28734717 |
| optimization of genotypic and biochemical methods to profile p. acnes isolates from a patient population. | propionibacterium acnes is a key factor in the pathogenesis of acne vulgaris, although currently it is also being associated with medical-device infections. the aim of this work was to validate a safe and quick identification and typing of 24 clinical isolates of propionibacterium acnes, applying a range of biochemical as well as genetic methods, and investigating the pathogenic potential to associate the different types with human health. rapd-pcrs revealed the existence of two discernible clus ... | 2017 | 28732695 |
| involvement of adenosine triphosphate-binding cassette subfamily b member 1 in the augmentation of triacylglycerol excretion by propionibacterium acnes in differentiated hamster sebocytes. | an onset of acne, a common inflammatory skin disease, is associated with excess sebum production and secretion in sebaceous glands. because propionibacterium acnes has been reported to augment intracellular sebum accumulation in sebaceous glands in hamsters, it remains unclear whether p. acnes influences sebum secretion from differentiated sebocytes. both p. acnes culture media (acnes73-cm) and formalin-killed p. acnes (f-acnes73) dose-dependently increased the extracellular levels of triacylgly ... | 2017 | 28714181 |
| the distribution of infection with propionibacterium acnes is equal in patients with cervical and lumbar disc herniation. | cervical and back pains are important clinical problems affecting human populations globally. it is suggested that propionibacterium acnes (p. acnes) is associated with disc herniation. the aim of this study is to evaluate the distribution of p. acnes infection in the cervical and lumbar disc material obtained from patients with disc herniation. | 2017 | 28712017 |
| current treatments of acne: medications, lights, lasers, and a novel 650-μs 1064-nm nd: yag laser. | the treatment of acne, especially severe acne, remains a challenge to dermatologists. therapies include retinoids, antibiotics, hormones, lights, lasers, and various combinations of these modalities. acne is currently considered a chronic rather than an adolescent condition. the appropriate treatment depends on the patient and the severity of disease. the purpose of this study was to review current therapies for acne of all severities and to introduce the 650-μs 1064-nm laser for the treatment o ... | 2017 | 28703382 |
| [diagnosis of periprosthetic joint infection of shoulder arthroplasties]. | periprosthetic joint infection of shoulder arthroplasties is one of the most frequent reasons for pain and revision surgery of shoulder arthroplasties. propionibacterium acnes is one of the commonest microorganisms causing periprosthetic joint infection in shoulder arthroplasties. it is difficult to detect this slow growing microorganism. this paper gives an overview of the different diagnostic methods. a combination of unspecific and specific tests (detection of microorganism and sensitivity to ... | 2017 | 28701012 |
| combined photodynamic and antibiotic therapy for skin disorder via lipase-sensitive liposomes with enhanced antimicrobial performance. | a lipase-sensitive singlet oxygen-producible and erythromycin-loaded liposome (lsspl) was developed for combination antibacterial therapy for skin disorder. the lsspl was synthesized by coating pullulan-pheophorbide a (pu-pheo a) conjugates onto erythromycin-loaded liposomes composed of 1,2-dipalmitoyl-sn-phosphatidylcholine (dppc) and cholesterol. lipase activity was chosen as the environmental-stimulus for the controlled release of erythromycin and pheo a from lsspl because skin inflammation-i ... | 2017 | 28697465 |
| association between post-craniotomy propionibacterium acnes infection and dural implants: a case-control study. | in 2011, 15 deep-seated propionibacterium acnes infections were identified in patients following craniotomies in a hospital in the uk. | 2017 | 28694086 |
| propionibacterium acnes host inflammatory response during periprosthetic infection is joint specific. | propionibacterium acnes (p. acnes) has become increasingly recognized as a cause of periprosthetic joint infection (pji). | 2017 | 28690466 |
| immunohistochemical identification of propionibacterium acnes in granuloma and inflammatory cells of myocardial tissues obtained from cardiac sarcoidosis patients. | although rare, cardiac sarcoidosis (cs) is potentially fatal. early diagnosis and intervention are essential, but histopathologic diagnosis is limited. we aimed to detect propionibacterium acnes, a commonly implicated etiologic agent of sarcoidosis, in myocardial tissues obtained from cs patients. | 2017 | 28686683 |
| a case of bilateral hilar and mediastinal lymphadenopathy developing during treatment for mycobacterium avium complex. | we report a rare case of an immunocompetent patient with mycobacterium avium complex (mac) disease in which bilateral hilar lymphadenopathy developed during anti-mac treatment. this case indicates that propionibacterium acnes would be present and might be a cause of sarcoidosis even in patients with mac. | 2017 | 28680616 |
| combination of benzoyl peroxide 5% gel with liquid cleanser and moisturizer spf 30 in acne treatment results in high levels of subject satisfaction, good adherence and favorable tolerability. | skin care products (cleansers and moisturizers) to complement benzoyl peroxide (bpo) in the treatment of acne may improve treatment tolerability and adherence. | 2017 | 28678647 |
| acne. | acne is a chronic disease with a high prevalence among adolescents. key pathogenetic factors (and their clinical correlates) are increased sebum production (seborrhea), follicular hyperkeratosis (comedones), and perifollicular inflammation (papules and pustules). the disease is modulated by a variety of endogenous (androgens, igf-1, neuroendocrine factors) and exogenous (propionibacterium acnes, diet, friction, ingredients of medical or cosmetic topical products) triggers. acne is associated wit ... | 2017 | 28677199 |
| akne. | akne ist eine chronische erkrankung mit hoher prävalenz unter jugendlichen. pathogenetische hauptfaktoren (und ihre klinischen korrelate) sind gesteigerte talgproduktion (seborrhoe), follikuläre hyperkeratose (komedonen) und perifollikuläre entzündungsvorgänge (papulopusteln). die krankheit wird von endogenen (androgene, igf-1, neuroendokrine faktoren) und exogenen (propionibacterium acnes, diät, mechanische irritation, inhaltsstoffe medizinischer oder kosmetischer externa) einflüssen moduliert. ... | 2017 | 28677193 |
| difficult-to-detect low-grade infections responsible for poor outcomes in total knee arthroplasty. | in this article, we present the case of a patient with a stiff, painful knee after total knee arthroplasty, and with erythrocyte sedimentation rate, c-reactive protein level, and synovial fluid analysis within normal limits. open biopsy for cultures showed propionibacterium acnes prosthetic joint infection, which was successfully treated with 2-stage revision and intravenous antibiotics. | 2017 | 28666043 |
| olumacostat glasaretil, a promising topical sebum-suppressing agent that affects all major pathogenic factors of acne vulgaris. | hunt et al. show that olumacostat glasaretil, an inhibitor of acetyl coenzyme a carboxylase, reduces saturated and monounsaturated fatty acyl chains in sebaceous lipids. topical olumacostat glasaretil application decreases hamster ear sebaceous gland size and shows efficacy in treating patients with acne vulgaris. olumacostat glasaretil-mediated sebum suppression may reduce propionibacterium acnes growth and biofilm formation, comedogenesis, and inflammation. | 2017 | 28647025 |
| sebum lipids influence macrophage polarization and activation. | as lipids are known to regulate macrophage functions it is reasonable to suppose that a sebocyte - macrophage axis mediated by sebum lipids may exist. | 2017 | 28646583 |
| propionibacterium acnes pleural empyema following medical thoracoscopy. | propionibacterium acnes (p. acnes) is a gram-positive anaerobic rod and a common skin commensal that colonizes sebaceous glands. it has infrequently been associated with invasive opportunistic infections and can cause implant-associated infections through a biofilm mode of growth. medical thoracoscopy is a common procedure for diagnosis and treatment of exudative pleural effusions; empyema is a recognized complication. we present a rare case of p. acnes pleural empyema 3 weeks following medical ... | 2017 | 28638619 |
| isotretinoin and lymecycline treatments modify the skin microbiota in acne. | oral retinoids and tetracyclines have a major role in acne treatment. here, we report for the first time the effect of isotretinoin and lymecycline therapy on the skin microbiota in cheek, back and armpit swab samples of acne vulgaris patients using 16s ribosomal rna (16s rrna) gene amplicon sequencing. propionibacterium acnes was the most common in sebaceous areas of healthy and untreated acne skin and more abundant in back than cheek samples. five taxa, including a streptococcus taxon, differe ... | 2017 | 28636791 |
| antibiotic resistance in acne treatment. | what is the evidence for antibiotic resistance in acne, and how does resistance affect treatment? | 2017 | 28636689 |
| tumour necrosis factor (tnf) inhibitor-induced isolated pleural granulomas: a rare adverse effect. | a 53-year-old man with a history of crohn's disease on infliximab, presented with several weeks of cough and dyspnoea. he had a right-sided pleural effusion, found to be exudative with lymphocytic predominance. he underwent right-sided video-assisted thoracic surgery (vats) with biopsies and pleurodesis. histopathology showed pleural-based non-caseating granulomas with unremarkable lung parenchyma. cultures were only positive for propionibacterium acnes 8 months later, he was found to have a lef ... | 2017 | 28630242 |
| accumulation of porphyrins in propionibacterium acnes by 5-aminolevulinic acid and its esters. | we have investigated the accumulation of porphyrins in propionibacterium acnes (p.acnes) by 5-aminolevulinic acid hydrochloride (ala) and its esters, ala methyl ester hydrochloride (mala), ala octyl ester hydrochloride (oala), and ala benzyl ester hydrochloride (bala). from the fluorescence spectra of porphyrins accumulated in p.acnes, the order of porphyrin accumulation is as follows: ala≫mala≈bala>oala (≈0). moreover, the pdt efficacy is reduced in the order of ala>mala≈bala>oala (≈without add ... | 2017 | 28624551 |
| antimicrobial susceptibility and phylogenetic analysis of propionibacterium acnes isolated from acne patients in japan between 2013 and 2015. | the prevalence of antimicrobial-resistant propionibacterium acnes strains isolated from acne patients has been increasing in japan. here, to estimate the current resistance rate, we tested antimicrobial susceptibility among p. acnes from acne patients having visited a specialized dermatology clinic between 2013 and 2015. rates of resistance to macrolides and clindamycin were 44.3 (31/70) and 38.6% (27/70), respectively. erm(x), which confers high-level clindamycin resistance (minimum inhibitory ... | 2017 | 28623856 |
| temporomandibular prosthetic joint infections associated with propionibacterium acnes: a case series, and a review of the literature. | the orthopedic literature has shown an increasing incidence of prosthetic joint infections (pjis) associated with propionibacterium acnes (p acnes). these infections present serious diagnostic and management challenges to the treating surgeons. in this review, the authors report on cases of p acnes-related temporomandibular joint (tmj) pjis that have been diagnosed and treated at their institution. | 2017 | 28623686 |
| propionibacterium acnes is an unusual cause of acute scrotal abscess in a preterm infant. | acute scrotal abscess is an extremely rare condition in neonates and may mimic testicular torsion. most of these abscesses have reportedly been due to staphylococcus and salmonella spp. infections. we herein report a unilateral acute scrotal abscess in a preterm infant born at 26 weeks in whom propionibacterium acnes was isolated from the collected scrotal fluid culture. to our knowledge, this is the first case report implicating p. acnes as a causative agent of neonatal scrotal abscess. based o ... | 2017 | 28620560 |
| a comparison of culture and pcr methods for identifying propionibacterium acnes in lesions isolated from patients with acne. | one of the factors that affect the occurrence of acne is the presence of propionibacterium acnes. the present study was conducted to compare the culture and polymerase chain reaction (pcr) methods for identifying p. acnes in lesions isolated from patients with acne. | 2017 | 28618752 |
| a polycation antimicrobial peptide mimic without resistance buildup against propionibacterium acnes. | a preliminary study is reported for a polycation antimicrobial peptide (amp) mimic against propionibacterium acnes, which is associated with acne vulgaris, a common skin condition. antibiotics are commonly used against p. acnes but buildup of resistance is well-known. worse, antibiotic regimens build up resistance for more sensitive bacteria such as staphylococcus epidermidis. the polycation amp mimic c12-50, 1, is chosen for the present study as it has been previously shown to have high antimic ... | 2017 | 28605136 |