| antibiotic susceptibility of propionibacterium acnes isolated from orthopaedic implant-associated infections. | prosthetic joint infections (pjis) caused by propionibacterium acnes account for a larger proportion of the total number of pjis than previously assumed and thus knowledge of the antimicrobial susceptibility patterns of p. acnes is of great value in everyday clinical practice. | 2015 | 25541476 |
| matrix-assisted laser desorption ionization time of flight mass spectrometry and diagnostic testing for prosthetic joint infection in the clinical microbiology laboratory. | identification of pathogen(s) associated with prosthetic joint infection (pji) is critical for patient management. historically, many laboratories have not routinely identified organisms such as coagulase-negative staphylococci to the species level. the advent of matrix-assisted laser desorption ionization time of flight mass spectrometry (maldi-tof ms) has enhanced clinical laboratory capacity for accurate species-level identification. the aim of this study was to describe the species-level ide ... | 2015 | 25533615 |
| curcumin attenuated acute propionibacterium acnes-induced liver injury through inhibition of hmgb1 expression in mice. | curcumin is a phenolic product isolated from the rhizome of curcuma longa and has protective effects on inflammatory diseases. here we investigated the protective effect of curcumin in acute propionibacterium acnes (p. acnes)-induced inflammatory liver injury. c57bl/6 mice were primed with p. acnes followed by lps challenge to induce fulminant hepatitis. curcumin or vehicle control was administered perorally by gavage once daily starting 2days before p. acnes priming. we found that curcumin sign ... | 2015 | 25510585 |
| preoperative and intraoperative infection workup in apparently aseptic revision shoulder arthroplasty. | the possibility of infection should be considered in every revision shoulder arthroplasty even in the absence of clinical symptoms and signs of infection because indolent infection is prevalent. detection of infection in apparently aseptic failed arthroplasties poses a diagnostic challenge as the conventional principles and criteria used for hip and knee arthroplasty are not generally applicable. propionibacterium acnes and staphylococcus epidermidis are among the infectious organisms most commo ... | 2015 | 25487903 |
| the effect of axillary hair on surgical antisepsis around the shoulder. | infection after shoulder surgery can have devastating consequences. recent literature has implicated propionibacterium acnes as a causative agent for postoperative shoulder infections. axillary hair removal has been suggested as a method for infection prevention, although data quantifying its effect on the bacterial load around the shoulder are lacking. | 2015 | 25487899 |
| presence of propionibacterium acnes in primary shoulder arthroscopy: results of aspiration and tissue cultures. | infection after shoulder surgery has a serious impact on patient outcome and costs associated with care. propionibacterium acnes infection may be insidious and manifest years after index surgery with resultant joint arthropathy or prosthesis infection. our goal was to evaluate the presence of p. acnes in a group of patients undergoing primary arthroscopic shoulder surgery to better understand this organism. | 2015 | 25483906 |
| synergistic effect of 2% chlorhexidine combined with proteolytic enzymes on biofilm disruption and killing. | to investigate the dynamics of a disinfection regimen using 1% trypsin and 1% proteinase k in combination with 2% chlorhexidine (with or without ultrasonics) using a nutrient-stressed endodontic multispecies model biofilm. | 2015 | 25482847 |
| update on blood culture-negative endocarditis. | blood culture-negative endocarditis is often severe, and difficult to diagnose. the rate of non-documented infective endocarditis has decreased with the advent of molecular biology - improved performance for the diagnosis of bacterial endocarditis with blood cultures sterilized by previous antibacterial treatment - and cardiac surgery - access to the main infected focus, the endocardium, for half of the patients. blood culture-negative endocarditis are classified in 3 main categories: (i) bacter ... | 2015 | 25480453 |
| emerging drugs for the treatment of acne. | acne is the most common skin condition in the us. the mainstay of acne therapy includes: topical retinoids, topical antibiotics, benzoyl peroxide (bp), and oral isotretinoin for severe cases. although these treatment options are highly effective they do have certain drawbacks. current acne treatment regimens often require patients to use multiple medications, some of which may have irritating side effects. furthermore, propionibacterium acnes resistance to antibiotics has become an increasing pr ... | 2015 | 25474485 |
| arthroscopic tissue culture for the evaluation of periprosthetic shoulder infection. | periprosthetic shoulder infections can be difficult to diagnose. the purpose of this study was to investigate the utility of arthroscopic tissue culture for the diagnosis of infection following shoulder arthroplasty. our hypothesis was that culture of arthroscopic biopsy tissue is a more reliable method than fluoroscopically guided shoulder aspiration for diagnosing such infection. | 2014 | 25471909 |
| treatment of acne with tea tree oil (melaleuca) products: a review of efficacy, tolerability and potential modes of action. | over-the-counter acne treatments containing tea tree oil from the plant melaleuca alternifolia are widely available, and evidence indicates that they are a common choice amongst those self-treating their acne. the aims of this review were to collate and evaluate the clinical evidence on the use of tea tree oil products for treating acne, to review safety and tolerability and to discuss the underlying modes of therapeutic action. | 2015 | 25465857 |
| mlst typing of antimicrobial-resistant propionibacterium acnes isolates from patients with moderate to severe acne vulgaris. | molecular typing data on antimicrobial-resistant propionibacterium strains are limited in the literature. we examined antimicrobial resistance profiles and the underlying resistance mechanisms in propionibacterium spp. isolates recovered from patients with moderate to severe acne vulgaris in greece. the clonallity of the resistant propionibacterium acnes isolates was also investigated. propionibacterium spp. isolates were detected using tryptone-yeast extract-glucose (tyg) agar plates supplement ... | 2015 | 25451716 |
| cosmeceuticals based on rhealba(®) oat plantlet extract for the treatment of acne vulgaris. | recent evidence suggests that acne vulgaris begins as an inflammation in and around the sebaceous gland and alterations in the lipid content of sebum, which drive hyperproliferation and increased desquamation of keratinocytes within sebaceous follicles. this prevents sebum drainage, causing the formation of microcomedones, which spontaneously regress or become acne lesions when the pilosebaceous unit is further blocked by the accumulation of corneocytes. these conditions are favourable for the p ... | 2014 | 25428278 |
| unexpected positive cultures including isolation of propionibacterium acnes in revision shoulder arthroplasty. | little information is available to guide treatment strategies regarding patients with unexpected positive cultures (upc), including propionibacterium acnes (pa), without overt signs of infection in revision shoulder arthroplasty (rsa). the purpose of our study was to analyze the prevalence, clinical meaning, treatment and prognosis of upc in rsa. | 2014 | 25421200 |
| comparison of airborne bacterial communities from a hog farm and spray field. | airborne bacteria from hog farms may have detrimental impacts on human health, particularly in terms of antibiotic resistance and pathogen zoonosis. despite human health risks, very little is known about the composition and diversity of airborne bacteria from hog farms and hog-related spray fields. we used pyrosequencing analysis of 16s rrna genes to compare airborne bacterial communities in a north carolina hog farm and lagoon spray field. in addition, we isolated and identified antibiotic-resi ... | 2015 | 25406533 |
| recent advances in acne pathogenesis: implications for therapy. | acne pathogenesis is a multifactorial process that occurs at the level of the pilosebaceous unit. while acne was previously perceived as an infectious disease, recent data have clarified it as an inflammatory process in which propionibacterium acnes and innate immunity play critical roles in propagating abnormal hyperkeratinization and inflammation. alterations in sebum composition, and increased sensitivity to androgens, also play roles in the inflammatory process. a stepwise approach to acne m ... | 2014 | 25388823 |
| fatty acid compositions of triglycerides and free fatty acids in sebum depend on amount of triglycerides, and do not differ in presence or absence of acne vulgaris. | to clarify the influence of the fatty acid composition of sebum in acne vulgaris, we investigated the amounts and fatty acid compositions of triglycerides (tg) and free fatty acids (ffa), and the amounts of cutaneous superficial propionibacterium acnes in acne patients and healthy subjects. the foreheads of 18 female patients, 10 male patients, 10 healthy females and 10 healthy males were studied in a japanese population. there were significant differences in the amounts of sebum, tg and cutaneo ... | 2014 | 25388081 |
| invasive propionibacterium acnes infections in a non-selective patient cohort: clinical manifestations, management and outcome. | an increasing number of reports suggest that propionibacterium acnes can cause serious invasive infections. currently, only limited data exist regarding the spectrum of invasive p. acnes infections. we conducted a non-selective cohort study at a tertiary hospital in the uk over a 9-year-period (2003-2012) investigating clinical manifestations, risk factors, management, and outcome of invasive p. acnes infections. forty-nine cases were identified; the majority were neurosurgical infections and or ... | 2015 | 25326276 |
| inhibitory and anti-inflammatory effects of the helicobacter pylori-derived antimicrobial peptide hpa3nt3 against propionibacterium acnes in the skin. | an effective treatment strategy for acne vulgaris is the reduction of propionibacterium acnes in the skin. the helicobacter pylori-derived synthetic antimicrobial peptide hpa3nt3 is a customized α-helical cationic peptide with antibacterial and anti-inflammatory activity. | 2014 | 25313444 |
| propionibacterium species and follicular keratinocyte activation in acneic and normal skin. | the pathogenesis of acne vulgaris is multifactorial with increased sebum production, alteration in the quality of sebum lipids, dysregulation of the hormone microenvironment, follicular hyperkeratinization and propionibacterium acnes-driven inflammation as major contributory factors. hyperproliferation of keratinocytes is believed to contribute to hypercornification and eventually leads to comedone development. while the distribution of p. acnes is relatively well documented in acneic and health ... | 2015 | 25279837 |
| role of bacterial biofilms in patients after reconstructive and aesthetic breast implant surgery. | capsular contracture is a feared complication following both reconstructive and aesthetic breast surgery. the etiology is uncertain, but bacterial biofilms have been suggested as trigger for chronic peri-implant inflammation, eventually leading to capsular contracture. | 2014 | 25272211 |
| association between propionibacterium acnes and frozen shoulder: a pilot study. | frozen shoulder has not previously been shown to be associated with infection. the present study set out to confirm the null hypothesis that there is no relationship between infection and frozen shoulder using two modern scientific methods, extended culture and polymerase chain reaction (pcr) for bacterial nucleic acids. | 2014 | 27582943 |
| aortic tube infections due to propionibacterium acnes. | | 2014 | 25263822 |
| proteome analysis of human sebaceous follicle infundibula extracted from healthy and acne-affected skin. | acne vulgaris is a very common disease of the pilosebaceous unit of the human skin. the pathological processes of acne are not fully understood. to gain further insight sebaceous follicular casts were extracted from 18 healthy and 20 acne-affected individuals by cyanoacrylate-gel biopsies and further processed for mass spectrometry analysis, aiming at a proteomic analysis of the sebaceous follicular casts. human as well as bacterial proteins were identified. human proteins enriched in acne and n ... | 2014 | 25238151 |
| resveratrol demonstrates antimicrobial effects against propionibacterium acnes in vitro. | resveratrol (3,5,4'-trihydroxystilbene) is an antioxidant that has multiple biologic effects including antimicrobial properties. acne vulgaris is a disease of the pilosebaceous unit, characterized by an inflammatory host immune response to the bacteria propionibacterium acnes (p. acnes). this study sought to determine whether resveratrol may be a potential treatment for acne vulgaris. | 2014 | 25228291 |
| inhibitory effects of bee venom on propionibacterium acnes-induced inflammatory skin disease in an animal model. | propionibacterium acnes (p. acnes) is a major contributing factor to the inflammatory component of acne. the many prescription medications for acne allow for a large number of potential combination treatments. however, several antibiotics, apart from their antibacterial effects, exert side‑effects, such as the suppression of host inflammatory responses. purified bee venom (bv) is a natural toxin produced by honeybees (apis mellifera l.). bv has been widely used as a traditional medicine for vari ... | 2014 | 25215662 |
| acute infection with propionibacterium acnes after a latarjet coracoid transfer procedure: a case report. | coracoid transfer procedures are highly effective at improving glenohumeral stability in patients with recurrent shoulder instability; complication rates from this procedure are generally low. we present the first case in the literature of a propionibacterium acnes (p. acnes) infection following a coracoid transfer. the case stresses the importance of proper antibiotic prophylaxis for patients undergoing latarjet procedures, as well as the workup for a painful postoperative shoulder, and the nee ... | 2016 | 25209204 |
| propionibacterium acnes infections in shoulder surgery. | perioperative shoulder infections involving propionibacterium acnes can be difficult to identify in a patient who presents with little more than pain and stiffness in the postoperative period. although indolent in its growth and presentation, infection of the shoulder with p acnes can have devastating effects, including failure of the surgical intervention. this article reviews the importance of a comprehensive physical, radiologic, and laboratory evaluation, and discusses appropriate preventive ... | 2014 | 25199422 |
| propionibacterium persists in the skin despite standard surgical preparation. | propionibacterium acnes, which normally resides in the skin, is known to play a role in surgical site infection in orthopaedic surgery. studies have suggested a persistence of propionibacteria on the skin surface, with rates of positive cultures ranging from 7% to 29% after surgical preparation. however, as propionibacterium organisms normally reside in the dermal layer, these studies may underestimate the true prevalence of propionibacteria after surgical skin preparation. we hypothesized that, ... | 2014 | 25187583 |
| propionibacterium acnes in shoulder surgery: true infection, contamination, or commensal of the deep tissue? | propionibacterium acnes has been linked to chronic infections in shoulder surgery. whether the bacterium is a contaminant or commensal of the deep tissue is unclear. we aimed to assess p. acnes in intraoperative samples of different tissue layers in patients undergoing first-time shoulder surgery. | 2014 | 25179369 |
| [advances in the research on bactericidal effect of blue light and its mechanism]. | blue light is commonly used to kill propionibacterium acnes in clinic. furthermore, blue light exhibits a good bactericidal effect against helicobacter pylori, methicillin-resistant staphylococcus aureus, pseudomonas aeruginosa, and many oral bacteria in laboratory studies. the bactericidal mechanism of blue light as commonly accepted consists photo-excitation of intracellular porphyrins resulting in production of cytotoxic reactive oxygen species which can inactivate bacteria. blue light can ki ... | 2014 | 25174390 |
| propionibacterium acnes populations involved in deep pathological samples and their dynamics along the cardiac surgical pathway. | propionibacterium acnes belongs to the normal skin microbiota, but it is also responsible for acne vulgaris and causes serious infections such as endocarditis and surgical site infections (ssi). the p. acnes population is structured into phylogenetic groups, with phylotype i being associated with acne. herein, we explore the link between phylotypes and clinical origins in a collection of p. acnes isolated from different body sites, involved in deep infections or healthcare-associated infections ... | 2015 | 25169966 |
| draft genome sequences of propionibacterium acnes type strain atcc6919 and antibiotic-resistant strain hl411pa1. | propionibacterium acnes is a major skin commensal and is associated with acne vulgaris, the most common skin disease. here we report the draft genome sequences of two p. acnes strains, the type strain atcc6919 and an antibiotic-resistant strain, hl411pa1. | 2014 | 25125638 |
| lipase-mediated lipid removal from propolis extract and its antiradical and antimicrobial activity. | propolis contains many antioxidants such as polyphenols and flavonoids. however, propolis-derived lipid components interrupt an efficient isolation of antioxidants from propolis extract. we examined the effectiveness of various lipase treatments for the removal of lipids from propolis extract and evaluated the biological features of the extract. | 2015 | 25123816 |
| a novel high-resolution single locus sequence typing scheme for mixed populations of propionibacterium acnes in vivo. | the gram-positive anaerobic bacterium propionibacterium acnes is a prevalent member of the normal skin microbiota of human adults. in addition to its suspected role in acne vulgaris it is involved in a variety of opportunistic infections. multi-locus sequence-typing (mlst) schemes identified distinct phylotypes associated with health and disease. being based on 8 to 9 house-keeping genes these mlst schemes have a high discriminatory power, but their application is time- and cost-intensive. here ... | 2014 | 25111794 |
| inositol and acne. | acne, once considered as a mere esthetic problem, is now recognized as a disease that can cause major disturbances of the psychological and emotional sphere. currently, the treatment of acne is focused on one or more pathogenic factors: hormonal stimulation and sebaceous hypersecretion, disorder of keratinization, colonization of propionibacterium acnes and inflammation. the aim of the paper was to evaluate the use of inositol in patients with moderate acne. | 2015 | 25077885 |
| fusidic acid in skin infections and infected atopic eczema. | skin infections represent an important public health issue and cost-driver. additionally, chronic skin lesions are sometimes colonized by gram-negative species. topical therapies are a key component in the management of mild-to-moderate skin infections. in such cases, topical antibiotics may be preferable to systemic treatment, since they maximize the effective doses at the site of infection while minimizing the systemic side effects of the drugs. however, the prevalence of resistant strains is ... | 2014 | 25068235 |
| protective effect of melittin against inflammation and apoptosis on propionibacterium acnes-induced human thp-1 monocytic cell. | melittin is a cationic, hemolytic peptide that is the main toxic component in the venom of the honey bee (apis mellifera). it has been used in treatment of various chronic inflammatory diseases. however, the cellular mechanism and the anti-apoptotic effect of melittin in propionibactierium acnes (p. acnes)-induced thp-1 cells have not been explored. in the present study, we investigated the anti-inflammatory and anti-apoptotic mechanism by examining the effect of melittin on p. acnes-induced thp ... | 2014 | 25062791 |
| pacemaker endocarditis caused by propionibacterium acnes in an adult patient with ebstein's anomaly: a report of a rare case. | we report a rare case of a brazilian adult woman with ebstein's anomaly who presented with pacemaker endocarditis caused by propionibacterium acnes. ebstein's anomaly is a rare congenital malformation of the heart. infective endocarditis is defined as an infection of heart valves, of the mural endocardium, of a septal defect, or of a cardiac electronic implantable device. propionibacterium acnes is a skin commensal bacterium, that is usually considered as a contaminant, but can, on rare occasion ... | 2014 | 25047281 |
| management of late (>1 y) deep infection after spinal fusion: a retrospective cohort study. | the incidence of late infection published in the literature varies from 1% to 12% with varying definition of late infection (range, 3 mo to 1 y). current evidence suggests implant removal and antibiotic therapy is necessary to clear these infections. a high incidence of late (>1 y) deep infection after instrumented spinal fusion was identified at our institution. we sought to evaluate the efficacy of our management of these patients. | 2015 | 25025743 |
| self-reported acne is not associated with prostate cancer. | some studies have suggested an inverse association between acne vulgaris and the acne-related bacterium propionibacterium acnes and prostate cancer (pca). self-reported acne might be an easily obtainable marker to identify men at relatively low risk of pca and might be incorporated into pca risk calculators. this study aimed to evaluate the association between self-reported acne and pca in a large case-referent study. | 2014 | 25011577 |
| propionibacterium acnes promotes th17 and th17/th1 responses in acne patients. | propionibacterium acnes is a gram-positive commensal bacterium thought to be involved in the pathogenesis of acne vulgaris. although the ability of p. acnes in the initiation of pro-inflammatory responses is well documented, little is known about adaptive immune responses to this bacterium. the observation that infiltrating immune cells consist mainly of cd4(+) t cells in the perifollicular space of early acne lesions suggests that helper t cells may be involved in immune responses caused by the ... | 2015 | 25010142 |
| polymicrobial chronic endophthalmitis diagnosed by culture and molecular technique. | accurate etiological diagnosis is the key to prevention of ocular morbidity in endophthalmitis cases. a 66 year old male was suffering from chronic endophthalmitis post-cataract surgery. polymerase chain reaction examination on anterior chamber fluid was positive for propionibacterium acnes but negative for the panfungal genome. he was advised vitrectomy with intravitreal injections. polymerase chain reaction of vitreous aspirate was positive for p.acnes as well as panfungal genome. the vitreous ... | 2014 | 25008833 |
| cellular activation in the immune response of sarcoidosis. | sarcoidosis is a chronic granulomatous disorder characterized by an accumulation of lymphocytes and macrophages in the alveoli. ultimately, long-lasting, nontreated disease results in a distortion of the microarchitecture of the lower respiratory tract. our current understanding of its pathogenesis is that several sequential immunological events finally resulting in granuloma formation are involved: (1) dependent on a susceptible genetic background described by a variety of functional polymorphi ... | 2014 | 25007083 |
| propionibacterium acnes: from commensal to opportunistic biofilm-associated implant pathogen. | propionibacterium acnes is known primarily as a skin commensal. however, it can present as an opportunistic pathogen via bacterial seeding to cause invasive infections such as implant-associated infections. these infections have gained more attention due to improved diagnostic procedures, such as sonication of explanted foreign materials and prolonged cultivation time of up to 14 days for periprosthetic biopsy specimens, and improved molecular methods, such as broad-range 16s rrna gene pcr. impl ... | 2014 | 24982315 |
| three dimensional distribution of propionibacterium acnes biofilms in human skin. | propionibacterium acnes is regarded as a common member of the human skin microbiota, often occurring in biofilms. little is known about the size of bacterial biofilms in hair follicles as a few sections of biopsy tissue are routinely evaluated. transversal sectioning provides a better opportunity for histological analyses of hair follicles which can be followed through the different morphological levels. direct visualization of p. acnes biofilms in hundreds of consecutive sections allowed insigh ... | 2014 | 24980271 |
| management of deep postoperative shoulder infections: is there a role for open biopsy during staged treatment? | despite the gold standard treatment of 2-stage exchange arthroplasty, reinfection after periprosthetic shoulder infections and periarticular osteomyelitis can be as high as 37%. this study describes a protocol to detect persistent deep shoulder infection before revision arthroplasty. | 2015 | 24972813 |
| complications of shoulder arthroscopy. | over the past 20 to 30 years, arthroscopic shoulder techniques have become increasingly popular. although these techniques have several advantages over open surgery, surgical complications are no less prevalent or devastating than those associated with open techniques. some of the complications associated with arthroscopic shoulder surgery include recurrent instability, soft-tissue injury, and neurapraxia. these complications can be minimized with thoughtful consideration of the surgical indicat ... | 2014 | 24966247 |
| anti-propionibacterium acnes assay-guided purification of brazilin and preparation of brazilin rich extract from caesalpinia sappan heartwood. | caesalpinia sappan l. (leguminosae or fabaceae) heartwood has been used as a coloring agent, with antibacterial activity in food, beverages, cosmetics, and garments. | 2014 | 24963948 |
| subacute bacterial endocarditis and subsequent shunt nephritis from ventriculoatrial shunting 14 years after shunt implantation. | fourteen years after shunt implantation, a 26-year-old patient with myelomeningocele, concomitant hydrocephalus and a ventriculoatrial cerebrospinal fluid (csf) shunt presented with brief but recurrent episodes of fever predominantly when taking showers or during physical exertion. after 4 years of inconclusive multidisciplinary investigations, the patient progressed into end-stage renal disease before an echocardiogram revealed a vegetative plaque on the tendinous chords of the tricuspid valve. ... | 2014 | 24962489 |
| safety of topical vancomycin for pediatric spinal deformity: nontoxic serum levels with supratherapeutic drain levels. | retrospective cohort analysis. | 2014 | 24921849 |
| re-evaluating treatment targets in acne vulgaris: adapting to a new understanding of pathophysiology. | two primary factors are changing current approaches to the management of acne vulgaris (av): the continuously evolving role of propionibacterium acnes in the pathophysiology of av and recent evidence of an inflammatory basis for av via innate immunity. the developing concepts emphasize that acne is primarily an inflammatory disease. the emerging concept of subclinical inflammation and its effect on development and progression of acne lesions correlating with the sequence of the underlying inflam ... | 2014 | 24918572 |
| isotretinoin therapy changes the expression of antimicrobial peptides in acne vulgaris. | in acne vulgaris, antimicrobial peptides (amps) could play a dual role; i.e., protective by acting against propionibacterium acnes, pro-inflammatory by acting as signalling molecules. the cutaneous expression of 15 different amps was investigated in acne patients; furthermore, the impact of isotretinoin therapy on amp expression was analysed in skin biopsies from 13 patients with acne vulgaris taken before, during and after a 6-month treatment cycle with isotretinoin using quantitative real-time ... | 2014 | 24916439 |
| systemic sarcoidosis with bone marrow involvement showing propionibacterium acnes in the lymph nodes. | | 2015 | 24909186 |
| intraspinal canal rod migration causing late-onset paraparesis 8 years after scoliosis surgery. | complete intraspinal canal rod migration with posterior bone reconstitution has never been described in the adolescent idiopathic scoliosis (ais) population. we present an unusual but significant delayed neurological complication after spinal instrumentation surgery. | 2016 | 24903395 |
| toll-like receptor 2 and p. acnes: do they trigger initial acne vulgaris lesions? | to elucidate the role of toll-like receptor 2 (tlr2) in the pathogenesis of acne vulgaris through its immunohistochemical localization in inflammatory and noninflammatory lesions of this disease entity. | 2014 | 24902362 |
| diagnosis and management of periprosthetic shoulder infections. | ➤ the unique bacterial flora of the shoulder present diagnostic and treatment challenges that are distinct from those seen with failed hip and knee arthroplasties.➤ the presentation, diagnosis, and management of suppurative periprosthetic joint infections of the shoulder are similar to those of the hip and the knee.➤ failed arthroplasties with positive cultures (fapcs) are poorly performing shoulder reconstructions associated with low-virulence microorganisms that do not evoke a suppurative infl ... | 2014 | 24897745 |
| novel pharmacological approaches for the treatment of acne vulgaris. | acne vulgaris is the most common skin disease worldwide; yet, current treatment options, although effective, are associated with unwanted side effects, chronicity, relapses and recurrences. the adequate control of the four pathogenic mechanisms, involved in the appearance of acne lesions, is paramount to treatment success. | 2014 | 24890096 |
| antimicrobial and anti-inflammatory activities of endophytic fungi talaromyces wortmannii extracts against acne-inducing bacteria. | acne vulgaris is the most common skin disease, causing significant psychosocial problems such as anxiety and depression similar to a chronic illness for those afflicted. currently, obtainable agents for acne treatment have limited use. thus, development of novel agents to treat this disease is a high medical need. the anaerobic bacterium propionibacterium acnes has been implicated in the inflammatory phase of acne vulgaris by activating pro-inflammatory mediators such as the interleukin-8 (il-8) ... | 2014 | 24887557 |
| yeast cell surface display of linoleic acid isomerase from propionibacterium acnes and its application for the production of trans-10, cis-12 conjugated linoleic acid. | conjugated linoleic acid (cla), a family of geometric and positional isomers of linoleic acid, has many health-promoting properties. different isomers of cla may have very different physiological effects. in the current work, we explore the possibility to produce single isomer of cla by using biocatalysis based on displayed biocatalysts on the yeast cell surfaces. a reporter system used to assess gene expression and protein distribution was established by combining the egfp gene to the n-terminu ... | 2015 | 24863409 |
| management of late postoperative capsular block syndrome with accumulation of propionibacterium acnes. | | 2014 | 24862790 |
| oral sarcoidosis: a case report and review of the literature. | sarcoidosis is a chronic multi-system immuno-inflammatory disorder characterized by non-caseating granulomatous infiltration of affected tissues that may result in fibrosis and organ dysfunction. it generally affects genetically predisposed young adults who develop a local dysregulated cell-mediated immune response towards an undefined 'sarcoidal antigen'. from recent data, it has become evident that propionibacterium acnes and mycobacterium tuberculosis are the probable antigenic agents which i ... | 2014 | 24862235 |
| infectious prosthetic hip joint loosening: bacterial species involved in its aetiology and their antibiotic resistance profiles against antibiotics recommended for the therapy of implant-associated infections. | reliable microbiological diagnosis along with surgery and prolonged antibiotic therapy are key elements in the management of prosthetic-joint infections (pjis). the purpose of this study was to characterize antibiotic resistance profiles of bacteria involved in the aetiology of pjis. a total of 33 bacterial isolates cultured from 31 patients undergoing exchange of total hip prostheses were analyzed. the diagnostic approach toward isolation of prosthesis- associated microorganisms included sonica ... | 2014 | 24858648 |
| current nanotechnological approaches for an effective delivery of bio-active drug molecules in the treatment of acne. | acne is a chronic inflammatory human skin disease, characterized by areas of skin with seborrhoea, comedones, papules, nodules, pimples, and possibly scarring with lesions occurring on face, neck, and back. nanotechnological approaches such as particulate (solid lipid nanoparticles and microspheres), vesicular (liposomes and niosomes), colloidal drug delivery systems (micro-emulsion and nano-emulsion), and miscellaneous systems (aerosol foams and micro-sponges) have an important place in acne th ... | 2016 | 24844191 |
| hemolysis as a clinical marker for propionibacterium acnes orthopedic infection. | determining if a propionibacterium acnes culture is a true infection or a contaminant remains a challenge. we conducted a study to distinguish between a true infection and a contaminated culture based on the p acnes hemolytic phenotype and clinical presentation. all p acnes strains were from orthopedic patients who had undergone arthroplasty or nonarthroplasty shoulder procedures. hemolysis was determined according to p acnes growth on brucella blood agar plates after 48 to 72 hours. each patien ... | 2014 | 24839635 |
| propionibacterium acnes activates the nlrp3 inflammasome in human sebocytes. | propionibacterium acne and sebaceous glands are considered to have an important role in the development of acne. although information regarding the activation of innate immunity by p. acnes in the sebaceous gland is limited, different p. acnes phylotypes and a higher prevalence of follicular p. acnes macrocolonies/biofilms in sebaceous follicles of skin biopsies from acne compared with control skin and occasionally single p. acnes clusters in single sebaceous glands have been detected. in this s ... | 2014 | 24820890 |
| importance of kupffer cells in the development of acute liver injuries in mice. | kupffer cells reside within the liver sinusoid and serve as gatekeepers. they produce pro- and anti-inflammatory cytokines and other biologically important molecules upon the engagement of pattern recognition receptors such as toll-like receptors. kupffer cell-ablated mice established by in vivo treatment with clodronate liposomes have revealed many important features of kupffer cells. in this paper, we review the importance of kupffer cells in murine acute liver injuries and focus on the follow ... | 2014 | 24802875 |
| development and characterization of a novel antiacne niosomal gel of rosmarinic acid. | the antibacterial and anti-inflammatory potential of rosemarinic acid (roa), a naturally occurring ester of caffeic acid has been well reported. antibacterial effect of roa is attributed to nucleoid damage with an increase in spatial division and condensation of genetic material. roa has been found dynamic against many human pathogenic bacterial strains but its inhibitory prospective has never been established against skin inflammations caused by propionibacterium acne. the skin surface in acne ... | 2015 | 24786487 |
| bacteriology and risk factors for development of late (greater than one year) deep infection following spinal fusion with instrumentation. | retrospective cohort review. | 2014 | 27927416 |
| constrictive infectious pericarditis caused by propionibacterium acnes. | | 2013 | 24775828 |
| vaccination of lambs against haemonchus contortus infection with a somatic protein (hc23) from adult helminths. | a somatic protein from adult haemonchus contortus (hc23), the most abundant component in a low molecular weight fraction with known immunizing effect against experimental haemonchosis, has been purified by immunochromatography. the immunoprophylactic value of hc23 was tested in groups of 5-6 months old assaf lambs using al(oh)(3) or escherichia coli lipopolysaccharide+inactivated propionibacterium acnes as adjuvant and the results compared with uninfected control, uninfected and challenged or in ... | 2014 | 24759430 |
| lower complication rates for cranioplasty with peri-operative bundle. | the overall benefits of craniectomy must include procedural risks from cranioplasty. cranioplasty carries a high risk of surgical site infections (ssi) particularly with antibiotic resistant bacteria. the goal of this study was to measure the effect of a cranioplasty bundle on peri-operative complications. | 2014 | 24731574 |
| poor utility of serum interleukin-6 levels to predict indolent periprosthetic shoulder infections. | infection after shoulder arthroplasty can present a diagnostic challenge. the purpose of this study was to evaluate the utility of serum interleukin-6 (il-6) levels in diagnosis of periprosthetic infection in patients undergoing revision shoulder arthroplasty. | 2014 | 24725902 |
| antibiotic stewardship in dermatology: limiting antibiotic use in acne. | widespread use of antibiotics in all areas of medicine has led to significant problems with antimicrobial resistance, which have begun to compromise the usefulness of antibiotics. antibiotics have long been a keystone of acne therapy. there is a large population of patients with acne and antibiotic therapy is often used for long durations; thus, acne therapy results in extensive antibiotic exposure. this article discusses the role of antibiotic therapy in acne from the perspective of how clinici ... | 2014 | 24721547 |
| inflammation and acne: putting the pieces together. | acne vulgaris is a common skin disease in which abnormal desquamation, excess sebum production, proliferation of propionibacterium acnes, and production of proinflammatory mediators all contribute to the pathogenesis of the disease. a review of the literature shows that our current understanding of acne pathogenesis continues to evolve. recent data suggests that inflammatory mediators may play a more important role than previously realized; however, how these mediators work independently as well ... | 2014 | 24719066 |
| antimicrobial and anti-inflammatory properties of nostocionone isolated from nostoc commune vauch and its derivatives against propionibacterium acnes. | propionibacterium acnes is the primary pathogenic agent responsible for acne vulgaris on the skin and hair follicles. overgrowth of this bacterium inhibits growth and promotes follicular inflammation, with an associated increase in pro-inflammatory cytokine production. p. acnes has therefore been considered the main target for the prevention and medical treatment of acne vulgaris. the aim of this study was to evaluate the in vitro anti-p. acnes and anti-inflammatory properties of 6 compounds iso ... | 2014 | 24699048 |
| pro-inflammatory cytokines in patients with various kinds of acne treated with isotretinoin. | acne vulgaris is the most frequently diagnosed dermatosis in patients aged between 11 and 30. it is believed that it affects about 80% of persons in this age group or even, taking into account lesions of low intensity, 100% of young people. the role of cytokines in the pathogenesis of acne is not fully known. the tlr2 receptors play a role in the aetiology of acne. stimulation of tlr2 by propionibacterium acnes makes the il-8 and il-12 concentrations increase. | 2014 | 24683393 |
| propionibacterium acnes, an emerging pathogen: from acne to implant-infections, from phylotype to resistance. | propionibacterium acnes colonizes the lipid-rich sebaceous glands of the skin. this preferential anaerobic bacterium is easily identified if cultures are prolonged. it is involved in the inflammation process of acne, but until recently, it was neglected in other clinical presentations. despite a reported low virulence, the new genomic, transcriptomic, and phylogenetic studies have allowed better understanding of this pathogen's importance that causes many chronic and recurrent infections, includ ... | 2014 | 24656842 |
| frozen section histology: a new tool to identify propionibacterium acnes infections in revision shoulder arthroplasty. commentary on an article by matthew j. grosso, bs, et al., "sensitivity of frozen section histology for identifying propionibacterium acnes infections in revision shoulder arthroplasty". | | 2014 | 24647516 |
| sensitivity of frozen section histology for identifying propionibacterium acnes infections in revision shoulder arthroplasty. | propionibacterium acnes is a clinically relevant pathogen with total shoulder arthroplasty. the purpose of this study was to determine the sensitivity of frozen section histology in identifying patients with propionibacterium acnes infection during revision total shoulder arthroplasty and investigate various diagnostic thresholds of acute inflammation that may improve frozen section performance. | 2014 | 24647499 |
| an exploratory study of microbial diversity in sinus infections of cystic fibrosis patients by molecular methods. | for the first time microorganisms in cf sinuses are investigated by molecular methods in response to an absence of anaerobes in cf sinus samples during a two-year period at the copenhagen cf center. | 2014 | 24636809 |
| lps and inactivated propionibacterium acnes elicit a partially protective response in primary infections of heligmosomoides polygyrus. | intestinal helminth infections are common and of paramount economic importance in domestic animals. available chemotherapy is limited and anthelmintic resistance is widespread in some hosts. this scenario favors the exploration of alternative methods of control, among them immune modulators. the effect of escherichia coli lps+propionibacterium acnes on a primary infection of heligmosomoides polygyrus (trichostongyloidea) in mice has been tested. nematode infection induced a rise of specific igg1 ... | 2014 | 24636785 |
| use of a recombinant cysteine proteinase from leishmania (leishmania) infantum chagasi for the immunotherapy of canine visceral leishmaniasis. | a recombinant cysteine proteinase from leishmania (leishmania) infantum chagasi (rldccys1) was previously shown to induce protective immune responses against murine and canine visceral leishmaniasis. these findings encouraged us to use rldccys1 in the immunotherapy of naturally infected dogs from teresina, piauí, a region of high incidence of visceral leishmaniasis in brazil. | 2014 | 24625516 |
| influence of different additives and their concentrations on corneal toxicity and antimicrobial effect of benzalkonium chloride. | the aim of this study was to examine the ophthalmic additives responsible for modulating acute corneal epithelial toxicity induced by benzalkonium chloride (bac) and investigate the ability of polyoxyethylene hydrogenated castor oil 40 (hco-40) and polysorbate 80 (ps-80) to reduce the corneal toxicity and antimicrobial effects of bac. | 2014 | 24619166 |
| optic neuropathy caused by propionibacterium acnes pachymeningitis. | we describe a patient with vision loss from an optic neuropathy caused by propionibacterium acnes pachymeningitis. the patient's optic neuropathy was stabilized with appropriate antibiotic therapy. | 2014 | 24614085 |
| adhesion of anaerobic bacteria to platelet containers. | anaerobic propionibacterium acnes and staphylococcus saccharolyticus are frequently isolated during platelet screening with anaerobic culture methods. although neither p. acnes nor s. saccharolyticus proliferates during platelet storage, both species survive well in this environment. this study was aimed at determining whether strains of p. acnes and/or s. saccharolyticus form surface-attached bacterial cell aggregates, known as biofilms, under platelet storage conditions. we report that these o ... | 2014 | 24602052 |
| propionibacterium acnes and staphylococcus lugdunensis cause pyogenic osteomyelitis in an intramedullary nail model in rabbits. | propionibacterium acnes and coagulase-negative staphylococci (cons) are opportunistic pathogens implicated in prosthetic joint and fracture fixation device-related infections. the purpose of this study was to determine whether p. acnes and the cons species staphylococcus lugdunensis, isolated from an "aseptically failed" prosthetic hip joint and a united intramedullary nail-fixed tibial fracture, respectively, could cause osteomyelitis in an established implant-related osteomyelitis model in rab ... | 2014 | 24599975 |
| intracellular propionibacterium acnes infection in glandular epithelium and stromal macrophages of the prostate with or without cancer. | recent reports on propionibacterium acnes (p. acnes) suggest that this bacterium is prevalent in the prostate, is associated with acute and chronic prostatic inflammation, and might have a role in prostate carcinogenesis. | 2014 | 24587325 |
| bone and joint infections due to anaerobic bacteria: an analysis of 61 cases and review of the literature. | the diagnosis of anaerobic bone and joint infections (bji) were underestimated before the advent of molecular identification and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (maldi-tof ms). we report 61 cases of anaerobic infections based on our 4-year experience with the management of bji. a total of 75% of cases were post-surgical infections, associated with osteosynthesis devices (65%). early infections occurred in 27% of cases, delayed infections in 17.5% of c ... | 2014 | 24577953 |
| clonality and anatomic distribution on the skin of antibiotic resistant and sensitive propionibacterium acnes. | increasing antibiotic resistance in the population of propionibacterium acnes is a major concern. our aims were to examine the clonal relationships and anatomical distribution of resistant and sensitive p. acnes. a collection of 350 p. acnes isolates was therefore used to determine the minimum inhibitory concentration of tetracycline, erythro-mycin and clindamycin, multilocus sequence type, and the identity of genetic resistance markers. two hitherto unknown resistance mutations were detected. r ... | 2014 | 24577497 |
| susceptibility profiles of propionibacterium acnes isolated from patients with acne vulgaris. | the wide prescription of antibiotics in patients with acne vulgaris has generated the concern of emergence of antibiotic-resistant propionibacterium acnes. to study the susceptibility profiles of p. acnes isolated from patients with acne vulgaris, 90 isolates were isolated from sebum collected from lesions of 191 patients. susceptibilities to amoxicillin, minocycline, erythromycin and clindamycin were studied by the etest method. thirty-four isolates (37.8%) were resistant to both erythromycin a ... | 2014 | 27873635 |
| a preliminary report on the use of antibiotic-impregnated methyl methacrylate in salvage cranioplasty. | in the setting of recurrent infection and multiple failed reconstruction attempts, the choice of the ideal reconstructive material for salvage cranioplasty remains a source of controversy in the literature. the purpose of this study is to establish the safety and utility of antibiotic-impregnated polymethyl methacrylate (pmma) for salvage cranioplasty.a prospectively maintained database of all patients who underwent salvage cranioplasty using vancomycin and tobramycin-impregnated methyl methacry ... | 2014 | 24561365 |
| interkingdom transfer of the acne-causing agent, propionibacterium acnes, from human to grapevine. | here, we report the surprising and, to our knowledge, unique example of horizontal interkingdom transfer of a human opportunistic pathogen (propionibacterium acnes) to a crop plant (the domesticated grapevine vitis vinifera l.). humans, like most organisms, have established a long-lasting cohabitation with a variety of microbes, including pathogens and gut-associated bacteria. studies which have investigated the dynamics of such associations revealed numerous cases of bacterial host switches fro ... | 2014 | 24554779 |
| anti-inflammatory effects of anthocyanins-rich extract from bilberry (vaccinium myrtillus l.) on croton oil-induced ear edema and propionibacterium acnes plus lps-induced liver damage in mice. | bilberry (vaccinium myrtillus l.) has been known to play a protective role in human health due to its high anthocyanin content. this study investigated the anti-inflammatory effects of bilberry extract (be, containing 42.04% anthocyanin) on propionibacterium acnes (p. acnes) plus lipopolysaccharide (lps) induced liver injury and croton oil-induced ear edema in mice. results showed that be could effectively inhibit croton oil-induced ear edema and liver inflammation provoked by p. acnes plus lps, ... | 2014 | 24548119 |
| severe inflammation associated with synovitis, acne, pustulosis, hyperostosis, osteitis (sapho) syndrome was markedly ameliorated by single use of minocycline. | we describe the case of a 63-year-old female who presented with severe inflammatory spondylitis, refractory to various antibiotics. mycobacterial and fungal osteomyelitis were unlikely. although asymptomatic, she also had osteomyelitis in the sternocostoclavicular region, and was suspected of having synovitis, acne, pustulosis, hyperostosis, osteitis (sapho) syndrome, against which minocycline showed marked efficacy. the presence of severe inflammatory sapho, albeit rare, together with the marke ... | 2014 | 24533553 |
| propionibacterium acnes biofilm endocarditis requiring radical cardiac debridement and prosthetic valve replacements. | | 2015 | 24529191 |
| acne, quorum sensing and danger. | propionibacterium acnes is a ubiquitous skin commensal bacterium, which is normally well tolerated by the immune system in healthy human skin. however, there is increasing evidence to suggest a pivotal role for p. acnes in the inflammatory process underlying the acne pathogenesis. with its features of inflammation and pustulation, acne vulgaris resembles the skin's normal reaction to bacterial pathogens. p. acnes flourishes when sebum production increases in the follicles. bacteria may undergo b ... | 2014 | 24524558 |
| relationship between the severity of acne vulgaris and antimicrobial resistance of bacteria isolated from acne lesions in a hospital in japan. | propionibacterium acnes and staphylococcus epidermidis are normal skin inhabitants that are frequently isolated from lesions caused by acne, and these micro-organisms are considered to contribute to the inflammation of acne. in the present study, we examined the antimicrobial susceptibilities and resistance mechanisms of p. acnes and s. epidermidis isolated from patients with acne vulgaris in a university hospital in japan from 2009 to 2010. additionally, we analysed the relationship between the ... | 2014 | 24523159 |
| inflammasome activation by propionibacterium acnes: the story of il-1 in acne continues to unfold. | insights into the immune mechanisms at play in skin diseases including acne continue to be made. in this issue, kistowska et al. confirm that propionibacterium acnes activates inflammasomes leading to the production of il-1β and they further identify putative mechanisms by which this process occurs. these data raise interesting questions regarding a multipronged approach by which p. acnes elicits inflammation in early versus late acne and putative differences in the effects of il-1α and il-1β in ... | 2014 | 24518111 |
| outcome and treatment of postoperative spine surgical site infections: predictors of treatment success and failure. | surgical site infection (ssi) is an important complication after spine surgery. the management of ssi is characterized by significant variability, and there is little guidance regarding an evidence-based approach. the objective of this study was to identify risk factors associated with treatment failure of ssi after spine surgery. | 2014 | 24510397 |