| activity of capryloyl collagenic acid against bacteria involved in acne. | synopsis capryloyl collagenic acid (lipacide c8co) has similar bacteriostatic activity in vitro to that of benzoyl peroxide towards the bacteria found in acne lesions (staphylococcus aureus, staphylococcus epidermidis and propionibacterium acnes) (mic between 1 and 4 mg ml(-1) for c8co, and between 0.5 and 5 mg ml(-1) for benzoyl peroxide). the presence of emulgine m8 did not affect the bacteriostatic activity of c8co. a 4% w/v solution of c8co (incorporating emulgine m8) fulfilled the criteria ... | 1989 | 19456955 |
| in vitro activities of three synthetic peptides derived from epinecidin-1 and an anti-lipopolysaccharide factor against propionibacterium acnes, candida albicans, and trichomonas vaginalis. | the synthetic epinecidin-1(22-42) peptide was derived from positions 22-42 of epinephelus coioides epinecidin-1. the synthetic salf(55-76) cyclic peptide (cssalf(55-76)) and salf(55-76) linear peptide (lssalf(55-76)) contained sequences from positions 55 to 76 of the penaeus monodon anti-lipopolysaccharide factor (alf), respectively. we studied the in vitro activities of epinecidin-1(22-42), cssalf(55-76), and lssalf(55-76) against propionibacterium acnes, candida albicans, and trichomonas vagin ... | 2009 | 19463737 |
| cryptomeria japonica essential oil inhibits the growth of drug-resistant skin pathogens and lps-induced nitric oxide and pro-inflammatory cytokine production. | in this study, the chemical composition of cryptomeria japonica essential oil (cje) was analyzed and its biological activities were tested. cje was obtained by steam distillation from leaves collected from jeju island and analyzed by gas chromatography (gc)-flame ionization detection (fid) and gc-ms. kaurene (17.20%), elemol (10.88%), gamma-eudesmol (9.41%), and sabinene (8.86%) were the major components in cje. the antibacterial and anti-inflammatory activities of cje against drug-susceptible a ... | 2009 | 19469288 |
| screening of platelet concentrates for bacterial contamination: spectrum of bacteria detected, proportionof transfused units, and clinical follow-up. | screening of platelet concentrates (pcs) for bacterial contamination with cultivation methods is carried out as a routine procedure in some countries. the aim is to prevent the transfusion of contaminated pcs. the german evaluation of regular monitoring study group conducted a prospective multicenter study on 52,243 pcs to investigate the prevalence of bacteria (bact/alert, biomerieux). this study describes the detected bacterial spectrum, the proportion of pcs with a positive test result that h ... | 2009 | 19484239 |
| sterilization of platelet concentrates at production scale by irradiation with short-wave ultraviolet light. | bacterial contamination of platelet concentrates (pcs) is recognized as a serious threat to transfusion safety. we developed a simple method for sterilization of pcs with short-wave ultraviolet light (uvc). the effects of treatment on the sterility of contaminated pcs and in vitro platelet (plt) variables were evaluated. | 2009 | 19497057 |
| frequency of bacterial contamination of platelet concentrates before and after introduction of diversion method in japan. | bacterial contamination of platelet concentrates (pcs) is the major infectious risk in transfusion medicine. to evaluate the necessity of implementing novel strategies for the reduction of bacterial contamination, it is necessary to establish a precise contamination frequency in pcs. | 2009 | 19500321 |
| vaccination of dogs with six different candidate leishmaniasis vaccines composed of a chimerical recombinant protein containing ribosomal and histone protein epitopes in combination with different adjuvants. | chimerical protein "q", composed of antigenic ribosomal and histone sequences, in combination with live bcg is a promising canine leishmaniasis vaccine candidate; one of the few vaccine candidates that have been tested successfully in dogs. unfortunately, live bcg is not an appropriate adjuvant for commercial application due to safety problems in dogs. in order to find a safe adjuvant with similar efficacy to live bcg, muramyl dipeptide, aluminium hydroxide, matrix c and killed propionibacterium ... | 2009 | 19500553 |
| contribution of tir domain-containing adapter inducing ifn-beta-mediated il-18 release to lps-induced liver injury in mice. | after treatment with heat-killed propionibacterium acnes mice show dense hepatic granuloma formation. such mice develop liver injury in an interleukin (il)-18-dependent manner after challenge with a sublethal dose lps. as previously shown, lps-stimulated kupffer cells secrete il-18 depending on caspase-1 and toll-like receptor (tlr)-4 but independently of its signal adaptor myeloid differentiation factor 88 (myd88), suggesting importance of another signal adaptor tir domain-containing adapter in ... | 2009 | 19501931 |
| species of propionibacterium and propionibacterium acnes phylotypes associated with orthopedic implants. | propionibacterium sp. is commonly isolated in association with orthopedic implants, either as a pathogen or a colonizer. microbial characteristics that indicate whether the isolated species is a likely cause of orthopedic implant infection versus a colonizing agent would be clinically useful. we performed a prospective trial to determine the species of propionibacterium and the phylotype (ia, ib, ii, iii) of propionibacterium acnes isolated from the surface of removed orthopedic implants, and we ... | 2009 | 19505429 |
| propionibacterium acnes brain abscess appearing 10 years after neurosurgery. | to describe a case of propionibacterium acnes infection arising 10 years after neurosurgery and to review the literature regarding similar cases and their treatment. | 2009 | 19506144 |
| spondylodiscitis due to propionibacterium acnes: report of twenty-nine cases and a review of the literature. | propionibacterium acnes is the most frequent anaerobic pathogen found in spondylodiscitis. a documented case required microbiological proof of p. acnes with clinical and radiological confirmation of inflammation in a localized region of the spine. microbiological samplings were obtained by surgery or aspiration under radiological control. twelve males and 17 females (median age, 42 years) with spondylodiscitis due to p. acnes were diagnosed within the last 15 years. three patients were immunosup ... | 2010 | 19519850 |
| histone h4 is a major component of the antimicrobial action of human sebocytes. | antimicrobial peptides, such as cathelicidin and beta defensins, directly kill microbes and have been detected in human sebaceous glands and cell lines. despite the presence of several such peptides, the apparent abundance of these is insufficient for direct killing of most skin pathogens. in this study, we sought to determine which molecules provide the majority of antimicrobial peptide activity in human sebocytes. acid-soluble protein extracts of seb-1 sebocytes were separated by reverse-phase ... | 2009 | 19536143 |
| comparison of 2 clindamycin 1%-benzoyl peroxide 5% topical gels used once daily in the management of acne vulgaris. | combination therapy for the topical treatment of acne vulgaris using benzoyl peroxide (bpo) and an antibiotic is more efficacious and better tolerated than treatment with either component alone. moreover, the addition of bpo to antibiotic therapy is recommended as a means of preventing the development of propionibacterium acnes antibiotic resistance. however, bpo is an irritant, and the dryness and irritation experienced by some patients using topical therapy containing bpo can negatively impact ... | 2009 | 19537284 |
| new developments in our understanding of acne pathogenesis and treatment. | interest in sebaceous gland physiology and its diseases is rapidly increasing. we provide a summarized update of the current knowledge of the pathobiology of acne vulgaris and new treatment concepts that have emerged in the last 3 years (2005-2008). we have tried to answer questions arising from the exploration of sebaceous gland biology, hormonal factors, hyperkeratinization, role of bacteria, sebum, nutrition, cytokines and toll-like receptors (tlrs). sebaceous glands play an important role as ... | 2009 | 19555434 |
| chloracne in seven organic chemists exposed to novel polycyclic halogenated chemical compounds (triazoloquinoxalines). | chloracne is an acneiform eruption caused though poisoning by aromatic compounds (usually halogenated) showing a specific molecular configuration. we describe an outbreak of chloracne among seven discovery chemists who synthesized novel polycyclic halogenated chemical compounds which were classified as triazoloquinoxalines, not known to be chloracnegenic. the diagnosis of chloracne, made clinically, elicited a thorough risk assessment and monitoring programme by the occupational health departmen ... | 2009 | 19558551 |
| antimicrobial activity of fullerenes and their hydroxylated derivatives. | the antimicrobial activities of fullerene c60 and its derivatives against 6 kinds of bacteria and 2 kinds of fungi were evaluated. the tested samples were water-soluble fullerenes (polyvinylpyrrolidone (pvp)/c60, gamma-cyclodextrin (gamma-cd)/c60, and nano-c60) and 3 types of fullerenols (c60(oh)12, c60(oh)36.8h2o, and c60(oh)44.8h2o). their activities were compared with those of (+)-catechin and hinokitiol from the viewpoint of future application to cosmetics. although pristine c60 demonstrated ... | 2009 | 19579658 |
| pathogenesis of acne vulgaris: recent advances. | acne vulgaris is the most common disorder seen in ambulatory dermatology practice. acne causes significant morbidity and the direct costs associated with it exceed $2.2 billion per year in the united states (u.s.). the pathogenesis is multifactorial, and our understanding of the mechanisms involved in the development of acne lesions has improved with time. follicular hyperkeratinization, sebum production, presence of propionibacterium acnes (p. acnes), inflammatory mediators, and androgens have ... | 2009 | 19588637 |
| comparative efficacy and safety results of two topical combination acne regimens. | combination therapy has become the standard for the management of acne, particularly for moderate-to-severe cases. among these combinations, those regimens containing benzoyl peroxide (bpo), clindamycin and a retinoid have been used frequently as they address most aspects of acne pathogenesis. this study compares the efficacy and safety of two common topical treatment regimens in the treatment of a moderate to severe facial acne vulgaris: fixed-combination gel containing bpo 5% and clindamycin 1 ... | 2009 | 19588638 |
| advancement in benzoyl peroxide-based acne treatment: methods to increase both efficacy and tolerability. | antibiotic resistance of propionibacterium acnes (p. acnes) is a growing phenomenon in the wake of widespread use of topical and systemic antibiotics for acne vulgaris. benzoyl peroxide has a proven track record of safety and efficacy, and can decrease reliance on antibiotics in the treatment of acne. | 2009 | 19588642 |
| infectious pericarditis: an experience spanning a decade. | although recent literature suggests a changing spectrum for infectious pericarditis (ip), this view has not been proven. in this report, we aim to review the features of ip in cases from a large tertiary centre. | 2009 | 19593938 |
| resolution of inflammation-related apoptotic processes by the synthetic tellurium compound, as101 following liver injury. | fulminant hepatic failure is a dangerous condition, which occurs when large parts of the liver become damaged beyond repair, and the liver is no longer able to function. this syndrome is induced by inflammatory processes, resulting in acute liver failure. recently, the organotellurium compound, trichloro(dioxoethylene-o,o(')) tellurate (as101), has been found by our group to be able to directly inhibit caspases, due to its te(iv)-thiol chemistry. the aim of this study was to examine the potentia ... | 2009 | 19595469 |
| the facial red fluorescence of ultraviolet photography: is this color due to propionibacterium acnes or the unknown content of secreted sebum? | red fluorescence of the face induced by ultraviolet light is thought to be due to propionibacterium acnes. however, recently there are reports correlating this red fluorescence with the amount of facial sebum secretion. this study was performed to investigate the relationship between the areas of facial red fluorescence with culture results of p. acnes and the amount of sebum secretion. | 2009 | 19622132 |
| heat-killed propionibacterium acnes is capable of inducing inflammatory responses in skin. | the etiology of acne is a complex process, and acne is one of the most common skin disorders affecting millions of people. the pathogenesis of acne is closely associated with the bacterium, propionibacterium acnes which was previously known as corynebacterium parvum. both viable and non-viable p. acnes/c. parvum have been shown to induce an immunostimulatory effect in vivo, suggesting that even dead bacteria continue to activate an inflammatory response. acne treatments with lasers or devices, i ... | 2009 | 19624731 |
| production of superoxide anions by keratinocytes initiates p. acnes-induced inflammation of the skin. | acne vulgaris is a chronic inflammatory disorder of the sebaceous follicles. propionibacterium acnes (p. acnes), a gram-positive anareobic bacterium, plays a critical role in the development of these inflammatory lesions. this study aimed at determining whether reactive oxygen species (ros) are produced by keratinocytes upon p. acnes infection, dissecting the mechanism of this production, and investigating how this phenomenon integrates in the general inflammatory response induced by p. acnes. i ... | 2009 | 19629174 |
| propionibacterium acnes endogenous endophthalmitis presenting with bilateral scleritis and uveitis. | | 2010 | 19648894 |
| efficacy of surgical preparation solutions in shoulder surgery. | deep infection following shoulder surgery is a rare but devastating problem. the use of an effective skin-preparation solution may be an important step in preventing infection. the purposes of the present study were to examine the native bacteria around the shoulder and to determine the efficacy of three different surgical skin-preparation solutions on the eradication of bacteria from the shoulder. | 2009 | 19651954 |
| cationic hypericin derivatives as novel agents with photobactericidal activity: synthesis and photodynamic inactivation of propionibacterium acnes. | the present communication describes for the first time the synthesis and preliminary testing of two cationic hypericin derivatives. uncharged hypericin derivatives with omega,omega'-attached c2-linkers leading to a pyridyl or a 4-dimethylaminophenyl residue were prepared and subsequently quaternized by means of iodomethane. photobactericidal activity was assessed using propionibacterium acnes. the quaternary n,n,n-trimethyl-anilinium derivative displayed a pronounced photodynamic inactivation of ... | 2009 | 19659921 |
| clinical and subclinical endometritis in the mare: both threats to fertility. | endometritis, a major cause of mare infertility arising from failure to remove bacteria, spermatozoa and inflammatory exudate post-breeding, is often undiagnosed. defects in genital anatomy, myometrial contractions, lymphatic drainage, mucociliary clearance, cervical function, plus vascular degeneration and inflamm-ageing underlie susceptibility to endometritis. diagnosis is made through detecting uterine fluid, vaginitis, vaginal discharge, short inter-oestrous intervals, inflammatory uterine c ... | 2009 | 19660076 |
| the antimicrobial activity of liposomal lauric acids against propionibacterium acnes. | this study evaluated the antimicrobial activity of lauric acid (la) and its liposomal derivatives against propionibacterium acnes (p. acnes), the bacterium that promotes inflammatory acne. first, the antimicrobial study of three free fatty acids (lauric acid, palmitic acid and oleic acid) demonstrated that la gives the strongest bactericidal activity against p. acnes. however, a setback of using la as a potential treatment for inflammatory acne is its poor water solubility. then the la was incor ... | 2009 | 19665786 |
| single low-dose red light is as efficacious as methyl-aminolevulinate--photodynamic therapy for treatment of acne: clinical assessment and fluorescence monitoring. | this controlled study investigated single low-dose red light photodynamic therapy and methyl-aminolevulinate (mal) for treatment of moderate to severe facial acne in 19 patients. the right cheek was treated with mal (160 mg/g) for 3 h prior to illumination. the left cheek received red light only. both cheeks were illuminated with narrow-band red light (635 nm) at a light dose of 15 j/cm2. the global severity of acne was assessed at baseline and at follow-up, 10 and 20 weeks after treatment. fluo ... | 2009 | 19688149 |
| 5-ala derivative-mediated photoinactivation of propionibacterium acnes. | | 2009 | 19709860 |
| non-purulent low-grade infection as cause of pain following shoulder surgery: preliminary results. | low-grade infection was systematically searched for in all revision shoulder surgeries by harvesting tissue samples. ten consecutive patients were identified with a non-purulent low-grade infection of the shoulder. all of these patients suffered from pain and eight were stiff. preoperative aspiration in eight patients yielded bacterial growth in only one case. serum c-reactive protein levels were normal in seven out of 10 cases. propionibacterium acnes was identified in seven, coagulase-negative ... | 2009 | 19711173 |
| squalene as a target molecule in skin hyperpigmentation caused by singlet oxygen. | based on our previous finding (biochem. biophys. res. commun., 223, 578-582, 1996) of singlet oxygen generation from coproporphyrin excreted on the skin surface from propionibacterium acnes, we hypothesized that singlet oxygen formed in this way under uv exposure would promote peroxidation of skin surface lipids. we found that squalene was oxidized efficiently by singlet oxygen derived from coproporphyrin under uv exposure, and that the rate constant of squalene peroxidation by singlet oxygen wa ... | 2009 | 19721223 |
| postoperative joint infections due to propionibacterium species: a case-control study. | we compared 40 patients with propionibacterium acnes postoperative joint infection to a cohort of uninfected patients. infection manifested a median of 210 days after surgery. most patients with joint prostheses underwent hardware removal. prior joint surgery (odds ratio [or], 28.2) and male sex (or, 7.2) were independent risk factors for infection. | 2009 | 19725786 |
| nicotinamide inhibits propionibacterium acnes-induced il-8 production in keratinocytes through the nf-kappab and mapk pathways. | propionibacterium acnes (p. acnes) has been implicated in the inflammatory phase of acne vulgaris. it has been shown to activate interleukin-8 (il-8) secretion by interacting with toll-like receptor 2 (tlr-2) on the surface of keratinocytes. nicotinamide has been shown to be an effective treatment for skin inflammation in various conditions, including acne vulgaris. | 2009 | 19726162 |
| in vitro activity of chlorhexidine and pentane-1,5-diol and their combination on candida albicans, staphylococcus aureus and propionibacterium acnes. | | 2009 | 19734980 |
| adjuvant effect of lps and killed propionibacterium acnes on the development of experimental gastrointestinal nematode infestation in sheep. | gastrointestinal helminthic infection is an important worldwide sheep disease. the emergence of anthelminthic resistance has led to drives to seek new means of therapeutic control of helminthiasis in sheep. several data demonstrated the adjuvant effect of propionibacterium acnes on resistance to infection. herein, we evaluate the adjuvant effect of the commercial suspension containing lps and p. acnes on experimental helminthiasis. sheep received three doses of lps and p. acnes commercial suspen ... | 2009 | 19751472 |
| antigen-dependent rescue of nose-associated lymphoid tissue (nalt) development independent of ltbetar and cxcr5 signaling. | nose-associated lymphoid tissue (nalt) in the rodent upper respiratory tract develops postnatally and is considered to be independent of several factors known to be involved in the organogenesis of ln and peyer's patches (pp). in this study we demonstrate that at least two different pathways result in nalt development. following nalt anlage formation the intrinsic pathway relies on a signaling cascade including those mediated through the chemokine receptor cxcr5 and the lymphotoxin beta receptor ... | 2009 | 19757439 |
| benzoyl peroxide: a review of its current use in the treatment of acne vulgaris. | owing to the use of topical and systemic antibiotics for acne vulgaris, the incidence of antibiotic-resistant propionibacterium acnes is increasing worldwide. topical benzoyl peroxide (bpo) is an alternative to antibiotics in the treatment of acne vulgaris. | 2009 | 19761357 |
| emerging drugs for acne. | acne vulgaris is a common skin disorder that affects most individuals at some point in their lives. it may result in significant morbidity, including cutaneous scarring and psychological impairment. current treatments include topical retinoids, benzoyl peroxide, topical and systemic antibiotics, and systemic isotretinoin. there are growing concerns of rising antibiotic resistance, significant side effects of isotretinoin therapy, and lack of safe and effective treatment for pregnant females. rec ... | 2009 | 19772370 |
| efficacy of antibiotic therapy for sapho syndrome is lost after its discontinuation: an interventional study. | the acronym sapho was introduced in 1987 to unify the various descriptions of a seronegative arthritis associated with skin manifestations and to show synovitis, acne, pustulosis, hyperostosis, and osteitis with and without sterile multifocal osteomyelitis. the etiology of sapho syndrome is unknown, but an association with infection by semipathogenic bacteria like propionibacterium acnes has been suggested. we conducted an interventional study of sapho patients receiving antibiotics. | 2009 | 19772564 |
| new insights into synovitis, acne, pustulosis, hyperostosis, and osteitis (sapho) syndrome. | in 1987, synovitis, acne, pustulosis, hyperostosis and osteitis (sapho) syndrome was proposed as an umbrella term for a group of diseases with similar musculoskeletal manifestations, in particular hyperostosis of anterior chest wall, synovitis, and multifocal aseptic osteomyelitis, observed in association with dermatologic conditions such as palmoplantar pustulosis, severe acne, and hidradenitis suppurativa. despite recent advances in our understanding of the epidemiologic, pathophysiologic, and ... | 2009 | 19772827 |
| incidence, clinical features, causative organisms, and visual outcomes of delayed-onset pseudophakic endophthalmitis. | to report the incidence, clinical features, causative organisms, and visual outcomes associated with delayed-onset pseudophakic endophthalmitis. | 2009 | 19787601 |
| photodynamic therapy of acne vulgaris using 5-aminolevulinic acid 0.5% liposomal spray and intense pulsed light in combination with topical keratolytic agents. | increasing antibiotic resistance of propionibacterium acnes and growing awareness on the side effects of topical and systemic drugs in the treatment of acne vulgaris by physicians and patients have paved the way for a search into new efficacious and safe treatment modalities such as photodynamic therapy (pdt). although the efficacy of pdt using 20% 5-aminolevulinic acid (ala) cream has been established, phototoxic side effects limit its use. the 5-ala concentration can be lowered by a factor of ... | 2010 | 19796088 |
| interleukin-10 secretion from cd14+ peripheral blood mononuclear cells is downregulated in patients with acne vulgaris. | acne is a common chronic inflammatory dermatosis of the pilosebaceous unit. it is characterized by seborrhoea, comedone formation and an inflammatory response consistent with defective cellular immunity to propionibacterium acnes. | 2010 | 19796181 |
| propionibacterium acnes and sebaceous lipogenesis: a love-hate relationship? | in this issue, iinuma et al. show that propionibacterium acnes (p. acnes)-conditioned medium and formalin-killed p. acnes augment intracellular lipid formation in hamster sebocytes by increasing the de novo synthesis of triacylglycerols. this commentary summarizes the current knowledge of the association of p. acnes with sebaceous lipogenesis, inflammation, and innate immunity, and points out the concurrent evidence that p. acnes-induced lipids may represent a recruitment of allies and/or enemie ... | 2009 | 19809423 |
| rapid identification of propionibacterium acnes from blood cultures by fluorescence in situ hybridization. | a newly designed probe for rapid identification of propionibacterium acnes by fluorescence in situ hybridization was evaluated using 111 isolates from subculture and showed 100% sensitivity and specificity. a sensitivity of 95% and a specificity of 100% were achieved with direct application on 55 blood cultures containing gram-positive rods. | 2010 | 19815363 |
| effect of konjac glucomannan hydrolysates and probiotics on the growth of the skin bacterium propionibacterium acnes in vitro. | the synbiotic ability of probiotic bacteria and konjac glucomannan hydrolysates (gmh) to inhibit acne-inducing bacterium, propionibacterium acnes growth was studied in vitro. all probiotic bacteria strains tested were able to inhibit the growth of this species of skin bacterium where the inhibition was significantly (p < 0.01) enhanced by the presence of the gmh prebiotic. as the current treatment of acne is based on topical or systemic drugs, it is worth examining further the biotherapeutic act ... | 2010 | 19818083 |
| detection and hazard assessment of pathogenic microorganisms in medical wastes. | this study was undertaken to investigate the types and concentrations of microbial agents in various medical wastes as well as to characterize their survivals in these wastes at different temperatures for microbial risk assessment. medical wastes collected from 5 major hospitals in south korea were classified and stored at three different temperatures (-20, 6, and 30 degrees c). presence of various microorganisms such as pathogenic viruses and bacteria were investigated by both cultivation and b ... | 2009 | 19827491 |
| characterization of bacterial flora in persistent apical periodontitis lesions. | microorganisms are able to survive and induce persistent infection in periapical tissues. the aim of this study was to investigate the composition of the microflora of persistent apical periodontitis lesions. | 2009 | 19832803 |
| treatment of active acne with an er:glass (1.54 microm) laser: a 2-year follow-up study. | to investigate the effects of the 1.54 microm wavelength on active lesions of the face and of the back at the 2-year follow-up. | 2006 | 19839169 |
| taurine bromamine: a new therapeutic option in inflammatory skin diseases. | acne vulgaris is a multifactorial inflammatory skin disease. one of the pathogenic factors in acne is propionibacterium acnes (p. acnes). traditional treatment of acne lesions involves topical application of antibiotics with anti-bacterial and anti-inflammatory properties. however, a failure of this therapy is widely associated with emergence of resistant bacteria. therefore, a search for alternative topical anti-acne drugs is necessary. taurine bromamine (taubr), the physiological product of hy ... | 2009 | 19847145 |
| oropharyngeal flora changes after tonsillectomy. | we aimed to investigate the effect of tonsillectomy on oropharyngeal flora in children who underwent tonsillectomy for chronic recurrent tonsillitis. | 2009 | 19861199 |
| suture-related complications after cataract surgery: a patient safety issue. | | 2009 | 19878852 |
| antimicrobial activity and stability of rhinacanthins-rich rhinacanthus nasutus extract. | rhinacanthins-rich rhinacanthus nasutus (rrn) extract was prepared and standardized to contain total rhinacantins not less than 70% w/w. in this study, antimicrobial activities of the rrn extract as well as rhinacanthin-c against streptococcus mutans, propionibacterium acnes, helicobacter pylori, staphylococcus aureus, s. epidermidis and candida albicans were evaluated by microdilution assay. it was found that the rrn extract exhibited potent bactericidal activity against s. mutans with mic and ... | 2010 | 19879741 |
| propionibacterium acnes infection after shoulder arthroplasty: a diagnostic challenge. | this study reviewed a series of patients diagnosed with propionibacterium acnes infection after shoulder arthroplasty in order to describe its clinical presentation, the means of diagnosis, and provide options for treatment. | 2010 | 19884021 |
| sapho syndrome: is a range of pathogen-associated rheumatic diseases extended? | sapho syndrome, representing a constellation of synovitis, acne, palmo-plantar pustulosis, hyperostosis, and osteitis, is now recognized as a distinct medical entity: a reactive infectious osteitis. genetic, immunological, and bacterial mechanisms are implicated in the development of the disease. diagnostic problems may arise due to non-complete manifestations of sapho: either acne and arthritis or acne and anterior wall osteitis with an unclear pustulosis history. the interventional study of as ... | 2009 | 19895718 |
| propionibacterium acnes as an etiological agent of arthroplastic and osteosynthetic infections--two cases with specific clinical presentation including formation of draining fistulae. | this report describes two patients with orthopaedic implant infections, with specific clinical presentations including formation of draining fistulae. propionibacterium acnes was isolated in multiple cultures in both cases. phenotypic and genetic characterisation of the isolates clearly emphasizes the significance of p. acnes as an etiological agent of implant infections. these infections are insidious with delayed presentation of symptoms and may have been overlooked because of the consideratio ... | 2010 | 19895893 |
| 18beta-glycyrrhetinic acid ameliorates acute propionibacterium acnes-induced liver injury through inhibition of macrophage inflammatory protein-1alpha. | 18beta-glycyrrhetinic acid (ga), the major bioactive component of licorice root extract, has a protective effect on hepatic injury and exhibits antiinflammatory activity. here, we investigate the effect of ga in propionibacterium acnes-induced acute inflammatory liver injury. c57bl/6 mice were primed with p. acnes followed by lipopolysaccharide challenge to induce fulminant hepatitis. ga (75 mg/kg) or vehicle control was administered intraperitoneally daily 1 day after p. acnes priming, and ga s ... | 2010 | 19897483 |
| acne vaccines targeting propionibacterium acnes. | acne vulgaris is one of the most common skin diseases and can affect a large number of individuals at some point in their lives. though the disease is multi-factorial, the gram-positive, anaerobic bacterium propionibacterium acnes (p. acnes), a member of resident skin microflora, is implicated in acne inflammation and associated with acne lesions. common treatments such as antibiotic or benzoyl peroxide nonspecifically reduce bacteria population on the skin, which may disrupt homeostasis and cau ... | 2009 | 19907403 |
| tibial chronic osteomyelitis due to propionibacterium acnes in a patient with sickle cell anemia. | | 2010 | 19913448 |
| metabolism of conjugated linoleic acids and 18 : 1 fatty acids by ruminal bacteria: products and mechanisms. | cultures of ruminal bacteria known to metabolize unsaturated fatty acids were grown in medium containing 50 microg ml(-1) of geometric and positional isomers of conjugated linoleic acid (cla) or 18 : 1 fatty acids and 37.4 % deuterium oxide to investigate the mechanisms responsible for fatty acid metabolism. butyrivibrio fibrisolvens jw11 converted cis-9,trans-11-18 : 2 and trans-9,trans-11-18 : 2 to trans-11-18 : 1 as the main product, labelled at c-9, and metabolized trans-10,cis-12-18 : 2 to ... | 2010 | 19926650 |
| in vitro antimicrobial activity of silver-processed catheters for neurosurgery. | to investigate the in vitro antibacterial activity of silver-processed catheters for use in neurosurgery using clinically predictive tests. | 2010 | 19942617 |
| suture-related corneal infections: should all sutures be routinely removed after phacoemulsification? | | 2009 | 19969244 |
| suture-related corneal infections. | | 2009 | 19969245 |
| identification of bacteria enduring endodontic treatment procedures by a combined reverse transcriptase-polymerase chain reaction and reverse-capture checkerboard approach. | this study identified the bacterial taxa enduring endodontic treatment procedures by using a combined 16s ribosomal rna-based reverse-transcriptase polymerase chain reaction (rt-pcr) and reverse-capture checkerboard hybridization approach. | 2010 | 20003934 |
| sebum free fatty acids enhance the innate immune defense of human sebocytes by upregulating beta-defensin-2 expression. | various sebum free fatty acids (ffas) have shown antibacterial activity against a broad range of gram-positive bacteria, resulting in the suggestion that they are accountable, at least partially, for the direct antimicrobial activity of the skin surface. in this study, we examined the effects of sebum ffas on the antimicrobial peptide (amp)-mediated innate immune defense of human sebocytes. incubation of lauric acid, palmitic acid, or oleic acid (oa) with human sebocytes dramatically enhanced th ... | 2010 | 20032992 |
| in vitro activities of azole antifungal agents against propionibacterium acnes isolated from patients with acne vulgaris. | the gram-positive bacterium propionibacterium acnes is the causative agent of acne vulgaris. antibiotics such as tetracycline and macrolide derivatives are used to treat this skin disease; however, the isolation frequency of antibiotic-resistant p. acnes has been increasing. the anti-p. acnes activity of imidazole antifungal agents was reported more than 20 years ago, and since then, new azole antifungal agents have been marketed. thus, this study determined the in vitro activities of azole anti ... | 2010 | 20045949 |
| syntheses of carnosic acid and carnosol, anti-oxidants in rosemary, from pisiferic acid, the major constituent of sawara. | carnosic acid (2), a major anti-oxidant in rosemary (rosmarinus officinalis), was synthesized from pisiferic acid (1), the major constituent of sawara (chamaecyparis pisifera), via ortho-oxidation of the phenol using meta-chlorobenzoyl peroxide (mcbpo), chloroacetyl meta-chlorobenzoyl peroxide (camcbpo) or 2-iodoxybenzoic acid (ibx). carnosol (3), another anti-oxidant in rosemary, was synthesized from carnosic acid by oxidation with silver oxide. potent antibacterial activities against propionib ... | 2010 | 20045961 |
| anaerobic bacteria as a cause of mycotic aneurysm of the aorta: microbiology and antimicrobial therapy. | this review summarizes the microbiology, and antimicrobial management of mycotic aneurysm of the aorta (maa) due to anaerobic bacteria. anaerobic bacteria are an uncommon but important cause of maa. most cases of anaerobic maa are caused anaerobic gram-negative bacilli (mostly b. fragilis group), clostridium spp. (mostly clostridium septicum, and propionobacterium spp. (mostly p. acnes). clostridial infection is frequently associated with gastrointestinal or hematologic malignancy. a review of a ... | 2009 | 20066146 |
| the role of propionibacterium acnes in acne pathogenesis: facts and controversies. | we have come a long way since 1896, when it was first suggested that propionibacterium acnes, found in acne lesions, was the cause of acne. although several lines of evidence suggest the direct role of p acnes in acne, the mechanism by which p acnes contributes to the pathogenesis of acne is debated. the importance of p acnes in the induction and maintenance of the inflammatory phase of acne has been established. emerging data that inflammatory events occur in the very earliest stages of acne de ... | 2010 | 20082942 |
| the role of facial sebum secretion in acne pathogenesis: facts and controversies. | increased sebum secretion has been known as one of the major pathogenic factors in the development of acne; however, objective sebum measurement methods have been developed only recently. we have limited information about the association of sebum secretion, and the development of acne. there continues to be controversy about the role of sebum in the development of acne. this contribution will discuss sebum measurement techniques and the results of recent studies on the relationship of sebum, fac ... | 2010 | 20082943 |
| bacterial contamination of the vitreous cavity associated with transconjunctival 25-gauge microincision vitrectomy surgery. | to evaluate differences in the bacterial contamination rates of the vitreous cavity between patients undergoing transconjunctival 25-gauge microincision vitrectomy surgery (mivs) and conventional 20-gauge pars plana vitrectomy (ppv). | 2010 | 20097429 |
| antibacterial effects of minerals from ores indigenous to korea. | we tested the antibacterial properties of a mix of minerals consisting mainly of sericite, talc, and halloysite from korea. the preparation showed clear growth inhibition of the gram-negative bacteria escherichia coli and pseudomonas aeruginosa, and the gram-positive bacteria staphylococcus aureus subsp. aureus, s. epidermidis, and bacillus cereus, as well as the anaerobic bacterium propionibacterium acnes. these results indicate that this preparation, made from ore minerals indigenous to korea, ... | 2009 | 20112878 |
| propionibacterium acnes in capsular bag distension syndrome. | we report a case of capsular bag distension syndrome that developed 6 years after uneventful phacoemulsification with implantation of a foldable, single-piece acrylic intraocular lens (iol) (acrysof ma60bm). slitlamp microscopy revealed a deep anterior chamber with no flare or cells. the posterior capsular bag was distended by a homogeneous milky substance between the back of the iol and the capsular bag. using a pars plana approach, a 23-gauge bimanual capsulotomy and anterior vitrectomy were p ... | 2010 | 20117721 |
| massive ascites as unique sign of shunt infection by propionibacterium acnes. | propionibacterium acnes (p. acnes) has been associated with shunt infection. the signs of infection are mild. we report on a case of p. acnes shunt infection presenting with massive ascites as the unique sign of csf infection. shunt removal, antibiotic therapy and drenaige of ascites were performed with a rapid clinical recovery. | 2010 | 20121383 |
| ifn-gamma is a master regulator of endotoxin shock syndrome in mice primed with heat-killed propionibacterium acnes. | hyper-coagulation, hypothermia, systemic inflammatory responses and shock are major clinical manifestations of endotoxin shock syndrome in human. as previously reported, mice primed with heat-killed propionibacterium acnes are highly susceptible to the action of lps to induce tumour necrosis factor (tnf)-alpha and to that of tnf-alpha to trigger lethal shock. here we investigated the mechanisms underlying the p. acnes-induced sensitization to lps and tnf-alpha and the development of individual s ... | 2010 | 20130231 |
| evaluation of the antibacterial activity of rhapontigenin produced from rhapontin by biotransformation against propionibacterium acnes. | biotransformation is often used to improve chemical activity. we evaluated the antimicrobial activity of rhapontigenin, converted from rhapontin after treatment with pectinex. rhapontigenin showed 4-16 times higher antimicrobial activity than rhapontin. activity was higher against gram positive strains than gram negative strains. minimum inhibitory concentrations (mics) of rhapontigenin, retinol, and five antibiotics were determined by microbroth dilution method for antibiotic-sensitive and -res ... | 2010 | 20134237 |
| improving diagnostic criteria for propionibacterium acnes osteomyelitis: a retrospective analysis. | the identification of propionibacterium acnes in cultures of bone and joint samples is always difficult to interpret because of the ubiquity of this microorganism. the aim of this study was to propose a diagnostic strategy to distinguish infections from contaminations. this was a retrospective analysis of all patient charts of those patients with >or=1 deep samples culture-positive for p. acnes. every criterion was tested for sensitivity, specificity, and positive likelihood ratio, and then the ... | 2010 | 20141491 |
| biological activities of schefflera leucantha. | this study investigated various biological activities of the ethanolic extract of dried ground leaves of schefflera leucantha viguier (araliaceae). the extract possessed very low cytotoxicity to brine-shrimp with the lc(50) of 4,111.15 microg/ml; the significant antioxidant activity on dpph with the ec(50) of 71.90 microg/ml; the inhibitory activity on mushroom tyrosinase with the ic(50) of 10.53 mg/ml using the dopachrome microplate-assay. the extract of 5-20 mg/ml range in the agar dilution as ... | 2006 | 20162087 |
| improved diagnosis of periprosthetic joint infection by multiplex pcr of sonication fluid from removed implants. | the microbiological diagnosis of periprosthetic joint infection (pji) is crucial for successful antimicrobial treatment. cultures have limited sensitivity, especially in patients receiving antibiotics. we evaluated the value of multiplex pcr for detection of microbial dna in sonication fluid from removed orthopedic prostheses. cases of pji in which the prosthesis (or part of it) was removed were prospectively included. the removed implant was sonicated, and the resulting sonication fluid was cul ... | 2010 | 20164283 |
| radiant near infrared light emitting diode exposure as skin preparation to enhance photodynamic therapy inflammatory type acne treatment outcome. | an alternative approach in the treatment of acne vulgaris is photodynamic therapy (pdt) that uses light and aminolevulinic acid (ala)-induced protoporphyrin ix (ppix) production to eradicate propionibacterium acnes found in acne lesions. ppix formation is dependent on ala percutaneaous penetration. in this study, to enhance ala penetration and subsequent accumulation of ppix, skin temperature was increased with radiant infrared (ir) prior to ala-pdt application and compared to ala-pdt alone in t ... | 2010 | 20166163 |
| antimicrobial activity of long-chain (e)-3-alken-2-ones. | (e)-3-tridecen-2-one, a compound identified from the interdigital glands of black-tailed deer (odocoileus hemionus columbianus), has been shown to inhibit the growth of bacteria and fungi. homologues of (e)-3-tridecen-2-one were prepared and screened for antimicrobial activity. for the fungus, trichophyton mentagrophytes, the minimum inhibitory concentration (mic) of (e)-3-tetradecen-2-one was 12.5 microg/ml, and for the bacteria, propionibacterium acnes, the mic of (e)-3-heptadecen-2-one was 3. ... | 2010 | 20185306 |
| propionibacterium acnes causing delayed postoperative spine infection: review. | propionibacterium acnes was previously considered a contaminant and its role in spine infection has been understated. although rare, such infections are present especially after instrumented spine surgery. they are usually delayed and hard to diagnose. delayed infection should be suspected in patients with pain and a history of spine surgery. in this article, we review the diagnostic challenges associated with delayed p. acnes infection after spine surgery, guided by relevant studies in the lite ... | 2010 | 20199135 |
| a randomized, investigator-blinded trial to assess the antimicrobial efficacy of a benzoyl peroxide 5%/ clindamycin phosphate 1% gel compared with a clindamycin phosphate 1.2%/tretinoin 0.025% gel in the topical treatment of acne vulgaris. | combination products in which the individual components have different mechanisms of antimicrobial action have been shown in many disease states to provide the most effective therapy. | 2010 | 20214175 |
| cutaneous induction of corticotropin releasing hormone by propionibacterium acnes extracts. | the skin commensal bacillus propionibacterium acnes is known to play a major role in the development of acne vulgaris and it is established that this bacteria is involved both in the induction and maintenance of the inflammatory phase of acne. the corticotropin releasing hormone (crh), a neuropeptide originally isolated from the hypothalamus, is also produced by the skin. crh has been reported to play a role in the inflammation, the production of sebum and finally the differentiation of keratino ... | 2009 | 20224691 |
| resolution of pigmented keratic precipitates following treatment of pseudophakic endophthalmitis caused by propionibacterium acnes. | propionibacterium acnes is a well-recognized cause of chronic postoperative endophthalmitis after cataract surgery. the subtle clinical signs of this infection and its initial favorable response to topical steroids may lead to delayed diagnosis and treatment. two patients with culture proven p. acnes endophthalmitis after cataract surgery that presented with prominent pigmented keratic precipitates (kps) and low-grade iritis in the involved eye were managed. both cases had initial treatment with ... | 2010 | 20337310 |
| infected giant ophthalmic artery aneurysm remnant following craniotomy for surgical clip ligation. case report. | postoperative intracranial infections, although found in only a minority of surgical cases, remain a recognized potential complication following elective craniotomy. in the treatment of intracranial aneurysms, specifically, reports of significant postoperative infections are rare. significant postoperative infections are usually observed in association with foreign bodies, such as aneurysm clips, endovascular coils, or materials used for aneurysm wrapping. the authors present a case in which a p ... | 2010 | 20345224 |
| effective and safe combination therapy for severe acne vulgaris: a randomized, vehicle-controlled, double-blind study of adapalene 0.1%-benzoyl peroxide 2.5% fixed-dose combination gel with doxycycline hyclate 100 mg. | there is a paucity of treatment options for severe acne vulgaris aside from oral isotretinoin. this randomized, vehicle-controlled, multicenter, double-blind study evaluated the efficacy and safety of combination therapy using adapalene 0.1%-benzoyl peroxide 2.5% (a/bpo) fixed-dose combination gel with doxycycline hyclate 100 mg in the treatment of severe acne vulgaris. a total of 459 participants were randomized in a 1:1 ratio to receive oral doxycycline hyclate 100 mg once daily and either a/b ... | 2010 | 20349684 |
| inhibitory effects of fortunella japonica var. margarita and citrus sunki essential oils on nitric oxide production and skin pathogens. | a number of essential oils from citrus peels are claimed to have biological activities. citrus peel, called 'jin-pi', is used in traditional medicine for digestion, severe cold, and fever. however, the antibacterial activities against skin pathogens and anti-inflammatory effects of the essential oils of citrus sunki (jingyul) and fortunella japonica var. margarita (gumgyul) have not yet been described. therefore, in this study, the essential oils of the citrus species c. sunki (cse) and f. japon ... | 2010 | 20350876 |
| bacterial colonization and infection of electrophysiological cardiac devices detected with sonication and swab culture. | electrophysiological cardiac devices are increasingly used. the frequency of subclinical infection is unknown. we investigated all explanted devices using sonication, a method for detection of microbial biofilms on foreign bodies. | 2010 | 20368521 |
| transdermal absorption enhancement through rat skin of gallidermin loaded in niosomes. | gallidermin (gdm) loaded in anionic niosomes composed of tween 61/chl/dp (1:1:0.05 molar ratio) gave the highest entrapment efficiency (45.06%). this formulation gave antibacterial activity against propionibacterium acnes and staphylococcus aureus with the mic and mbc of 3.75 and 7.5; 7.5 and 15 microg/microl, respectively. gdm loaded in niosomes was more chemically stable than gdm in aqueous solution of about 1.5 times. gdm loaded and unloaded in niosomes were not found in the receiver solution ... | 2010 | 20381599 |
| heart valve allograft decontamination with antibiotics: impact of the temperature of incubation on efficacy. | heart valve allografts are typically processed at 4°c in north america, including the step of antibiotic decontamination. in our own experience with heart valve banking, we often observe persistent positive cultures following decontamination at wet ice temperature. we hypothesized that warmer temperatures of incubation might increase the efficacy of the decontamination procedure. in a first series of experiments, 12 different bacterial species were grown overnight, frozen in standardized aliquot ... | 2010 | 20390362 |
| propionibacterium acnes infection induces upregulation of inflammatory genes and cytokine secretion in prostate epithelial cells. | the immune stimulating bacterium propionibacterium acnes is a frequent colonizer of benign and malignant prostate tissue. to understand the pathogenesis of the earliest phase of this infection, we examined the p. acnes triggered immune response in cultivated prostate epithelial cells. | 2010 | 20420679 |
| experimental pulmonary granuloma mimicking sarcoidosis induced by propionibacterium acnes in mice. | propionibacterium acnes has been implicated as an etiologic agent of sarcoidosis since the isolation of this bacterium from sarcoid lesions. we experimentally produced a murine pulmonary granuloma model using p. acnes with several features that simulate sarcoidosis. mice were sensitized with heat-killed p. acnes and complete freund's adjuvant and were subsequently challenged with heat-killed p. acnes at 2-week intervals. p. acnes-challenged mice developed epitheloid cell granulomas in the lungs. ... | 2010 | 20424662 |
| quantitative pcr of propionibacterium acnes dna in samples aspirated from sebaceous follicles on the normal skin of subjects with or without acne. | to elucidate whether people with hair follicles containing many propionibacterium acnes cells are prone to acne, we developed a novel method to count the number of p. acnes in hair follicles. we sampled sebaceous material in hair follicles by aspiration at a constant negative pressure from the nose, forehead, and upper arm of 86 patients with acne vulgaris and 209 control subjects with healthy skin, including 84 subjects age-matched to the patients. genome-equivalents of p. acnes in samples were ... | 2010 | 20437767 |
| a biofilm approach to detect bacteria on removed spinal implants. | this is a prospective study comparing the diagnosis of spinal implant infection by conventional peri-implant tissue culture with a technique which uses a combination of vortexing and bath sonication to dislodge bacteria growing as a biofilm on the surface of retrieved spinal implants. | 2010 | 20445479 |
| bacterial resistance in french acne patients. | the percentage of strains of propionibacterium acnes resistant to antibiotics in acne is increasing in many countries, raising the question of the risks associated with bacterial resistance. numerous series of cases have been published on european populations of acne patients, but at the moment we still have very few data regarding france. | 2010 | 20465665 |
| trends in the treatment of acne vulgaris: are measures being taken to avoid antimicrobial resistance? | acne vulgaris has been treated with long-term courses of antibiotics since the 1960s. antibiotic-resistance of propionibacterium acnes (p. acnes) was first documented in the late 1970s, and, over 20 years later, the problem of antibiotic resistance still exists. | 2010 | 20480795 |
| evaluation of the bact/alert 3d system for the implementation of in-house quality control sterility testing at canadian blood services. | background: until recently, canadian blood services (cbs) was performing quality control sterility testing of blood components using three different processes. this study was conducted in order to standardize sterility testing at all cbs centers in a cost-effective manner using the bact/alert 3d system. methods: blood components including fresh frozen plasma, platelet concentrates, and red blood cells were inoculated with eight bacterial species at target concentrations of 1 and 10 cfu/ml. pre- ... | 2010 | 20482299 |