| mathematical evaluation of the amino acid and polyphenol content and antioxidant activities of fruits from different apricot cultivars. | functional foods are of interest because of their significant effects on human health, which can be connected with the presence of some biologically important compounds. in this study, we carried out complex analysis of 239 apricot cultivars (prunus armeniaca l.) cultivated in lednice (climatic area t4), south moravia, czech republic. almost all previously published studies have focused only on analysis of certain parameters. however, we focused on detection both primary and secondary metabolite ... | 2011 | 21886093 |
| Clinical and Pathologic Characteristics of Biopsy-Proven Iris Melanoma: A Multicenter International Study. | OBJECTIVE: To collaborate with multiple centers to identify representative epidemiological, clinical, and pathologic characteristics of melanoma of the iris. This international, multicenter, Internet-assisted study in ophthalmic oncology demonstrates the collaboration among eye cancer specialists to stage and describe the clinical and pathologic characteristics of biopsy-proven melanoma of the iris. METHODS: A computer program was created to allow for Internet-assisted multicenter, privacy-prote ... | 2011 | 21911649 |
| Excess body fat is associated with higher risk of vertebral deformities in older women but not in men: a cross-sectional study. | Thinness is a risk factor for fractures, but the effect of obesity on fracture risk is less clear. We found an association between measures of obesity and prevalence and number of vertebral deformities in women but not in men, in a cross-sectional study of 1,011 participants aged 50-80 years. | 2012 | 21850547 |
| successful downstaging of high rectal and recto-sigmoid cancer by neo-adjuvant chemo-radiotherapy. | the benefit of neoadjuvant therapy for tumours above the peritoneal reflection is not clear. the purpose of this study is to demonstrate the feasibility and downstaging of treating locally advanced tumours from high rectum to distal sigmoid with preoperative chemoradiotherapy (crt). | 2008 | 21892276 |
| evaluation of adjuvant chemoradiation therapy for ampullary adenocarcinoma: the johns hopkins hospital-mayo clinic collaborative study. | the role of adjuvant chemoradiation therapy for ampullary carcinoma is unknown. previous literature suggests that certain populations with high risk factors for recurrence may benefit from adjuvant chemoradiation. we combined the experience of two institutions to better delineate which patients may benefit from adjuvant chemoradiation. | 2011 | 21951377 |
| Complete Genome Sequence of the Giant Virus OBP and Comparitive Genome Analysis of the Diverse {varphi}KZ-Related Phages. | The 283,757 bp dsDNA genome of Pseudomonas fluorescens phage OBP shares a general genomic organization with Pseudomonas aeruginosa phage EL. Comparison of this genomic organization assembled in syntenic genomic blocks interspersed with hyperplastic regions of the ?KZ-related phages, supports the proposed division in the "EL-like viruses", and the "phiKZ-like viruses" within a larger subfamily. Identification of putative early transcription promoters scattered throughout the hyperplastic regions, ... | 2011 | 22130535 |
| Diet exposure to technical hexabromocyclododecane (HBCD) affects testes and circulating testosterone and thyroxine levels in American kestrels (Falco sparverius). | Hexabromocyclododecane (HBCD) is a high-production-volume, brominated flame-retardant that is used in items such as polystyrene foams. HBCD has been detected in the environment, wildlife tissues and in humans globally with some of the highest recorded levels in predatory birds. This study examined the effects of exposure to environmentally relevant levels of HBCD on the reproductive physiology of captive male American kestrels (Falco sparverius), a predatory bird. Two sets of males were used: on ... | 2011 | 21917248 |
| Swallowing function after transoral laser microsurgery (TLM) ± adjuvant therapy for advanced-stage oropharyngeal cancer. | To perform a longitudinal description of swallowing function following transoral laser microsurgery (TLM) ± adjuvant therapy for advanced-stage oropharyngeal cancer (OPC) and identify prognostic factors associated with swallowing performance. | 2011 | 21882203 |
| Multi-Institutional Analysis of Robotic Radical Cystectomy for Bladder Cancer: Perioperative Outcomes and Complications in 227 Patients. | Abstract Purpose: Recently, some surgeons have begun to describe single-institution case series with less invasive surgical approaches to bladder cancer such as laparoscopic or robotic-assisted techniques. We report on a multi-institutional, multi-surgeon experience with robotic radical cystectomy with regard to operative and pathologic outcomes and complications to evaluate the feasibility and reproducibility of this technique in a large cohort of patients. Subjects and Methods: Two hundred ... | 2011 | 22142028 |
| Structure-function analysis of HsiF, a gp25-like component of the type VI secretion system, in Pseudomonas aeruginosa. | Bacterial pathogens use a range of protein secretion systems to colonize their host. One recent addition to this arsenal is the type VI secretion system (T6SS), which is found in many Gram-negative bacteria. The T6SS involves 12-15 components, including a ClpV-like AAA(+) ATPase. Moreover, the VgrG and Hcp components have been proposed to form a puncturing device, based on structural similarity to the tail spike components gp5/gp27 and the tail tube component gp19 of the T4 bacteriophage, respec ... | 2011 | 21873404 |
| Gastrectomy as a secondary surgery for stage IV gastric cancer patients who underwent S-1-based chemotherapy: a multi-institute retrospective study. | BACKGROUND: Current advances in chemotherapy provide opportunities for stage IV gastric cancer patients with distant metastasis to undergo potentially curable resection. There are, however, few data on gastrectomy as a secondary surgery aimed at rendering such patients cancer-free. METHODS: We investigated stage IV gastric cancer patients who underwent surgery with curative intent after S-1-based chemotherapy bet ... | 2011 | 22033890 |
| multiple synchronous primary tumours in a single lobe. | we present the case of a 70-year-old man with three synchronous histologically different primary tumours in the same lobe. he initially presented with an intermittent productive cough, dyspnoea and non-specific abdominal pains. radiological investigation revealed three areas of high-intensity fludeoxyglucose uptake of varying size within the right upper lobe. he underwent thoracoscopic right upper lobectomy. histological analysis confirmed the three lesions to be undifferentiated squamous cell c ... | 2011 | 22159234 |
| Sequential evaluations of trace elements in patients receiving parenteral nutrition. | To evaluate alterations of serum trace element (TE) levels in critically ill patients receiving parenteral nutrition (PN) including the recommended doses of TEs. | 2011 | 21940305 |
| [association between a meningioma and an occult thyroid carcinoma in congenital hypothyroidism.] | the presence of a thyroid carcinoma and a defect in thyroid hormone synthesis in a 27 year ols female is reported. when she was 13 years old a clinical diagnosis of hypothyroid cretinism was made, based on a defect of iodide organification which was demostrated by thiocyanate test showing a discharge of 55 % of 131i at 45 minutes. she intermittently received thyroid hormone until she died. few days before dying she had normal values of t3, t4 and tsh. her parents are related and she had a 35 yea ... | 1980 | 22167704 |
| phase ii trial of preoperative chemotherapy with docetaxel, cisplatin and s-1 for t4 locally advanced gastric cancer. | the standard treatment for t4 locally advanced gastric cancer is gastrectomy with d2 lymph node dissection followed by adjuvant chemotherapy with s-1 for 12 months; however, prognostic outcome in stage iiib has been insufficient. it is expected that survival is improved by preoperative treatment with a triplet regimen of docetaxel, cisplatin and s-1 (divided dcs therapy). a multicenter phase ii study has been conducted to evaluate the safety and efficacy of two courses of preoperative chemothera ... | 2011 | 22167664 |
| Prediction of long-term disability in multiple sclerosis. | Background: Little is known about the predictive value of neurophysiological measures for the long-term course of multiple sclerosis (MS). Objective: To prospectively investigate whether combined visual (VEP) and motor evoked potentials (MEP) allow prediction of disability over 14 years. Methods: A total of 30 patients with relapsing-remitting and secondary progressive MS were prospectively investigated with VEPs, MEPs and the Expanded Disability Status Scale (EDSS) at entry (T0) and after 6, 12 ... | 2011 | 21868486 |
| EFFECT OF GLUCOCORTICOID ADMINISTRATION ON ADRENAL GLAND SIZE AND SONOGRAPHIC APPEARANCE IN BEAGLE DOGS. | Our aim was to evaluate the influence of glucocorticoids on the adrenal gland using ultrasonography. Eleven healthy beagles were used in a prospective placebo-controlled study. All dogs received hydrocortisone at 10 mg/kg twice a day per os for 4 months or a gelatin capsule twice a day per os as a placebo. Clinical and endocrinologic examination of the dogs and ultrasonographic evaluation of adrenal echogenicity, shape, and measurement of the length and height of the cranial and caudal pole were ... | 2011 | 22092685 |
| Sensillum-specific, topographic projection patterns of olfactory receptor neurons in the antennal lobe of the cockroach Periplaneta americana. | In vertebrates and many invertebrates, olfactory signals detected by peripheral olfactory receptor neurons (ORNs) are conveyed to a primary olfactory center with glomerular organization in which odor specific activity patterns are generated. In the cockroach, Periplaneta americana, ORNs in antennal olfactory sensilla project to 205 unambiguously identifiable antennal lobe (AL) glomeruli that are classified into 10 glomerular clusters (T1-T10 glomeruli) innervated by distinct sensory tracts. In t ... | 2011 | 22121009 |
| critical behavior of megabase-size dna toward the transition into a compact state. | we studied the changes in the higher-order structure of a megabase-size dna (s120-1 dna) under different spermidine (spd) concentrations through single-molecule observations using fluorescence microscopy (fm) and atomic force microscopy (afm). we examined the difference between the folding transitions in s120-1 dna and sub-megabase-size dna, t4 dna (166 kbp). from fm observations, it is found that s120-1 dna exhibits intra-chain segregation as the intermediate state of transition, in contrast to ... | 2011 | 22168726 |
| t⁴ workshop report. nanotoxicology: "the end of the beginning" - signs on the roadmap to a strategy for assuring the safe application and use of nanomaterials. | in october 2010, a group of experts met as part of the transatlantic think tank for toxicology (t4) to exchange ideas about the current status and future of safety testing of nanomaterials. at present, there is no widely accepted path forward to assure appropriate and effective hazard identification for engineered nanomaterials. the group discussed needs for characterization of nanomaterials and identified testing protocols that incorporate the use of innovative alternative whole models such as ... | 2011 | 21993959 |
| probing the substrate specificity of the bacterial pnkp/hen1 rna repair system using synthetic rnas. | ribotoxins cleave essential rnas involved in protein synthesis as a strategy for cell killing. rna repair systems exist in nature to counteract the lethal actions of ribotoxins, as first demonstrated by the rna repair system from bacteriophage t4 25 yr ago. recently, we found that two bacterial proteins, named pnkp and hen1, form a stable complex and are able to repair ribotoxin-cleaved trnas in vitro. however, unlike the well-studied t4 rna repair system, the natural rna substrates of the bacte ... | 2011 | 22190744 |
| changes of thyroid hormone levels and related gene expression in zebrafish on early life stage exposure to triadimefon. | in this study, zebrafish was exposed to triadimefon. thyroid hormones levels and the expression of related genes in the hypothalamic-pituitary-thyroid (hpt) axis, including thyroid-stimulating hormone (tsh-beta), deiodinases (dio1 and dio2) and the thyroid hormone receptor (thraa and thrb) were evaluated. after triadimefon exposure, increased t4 can be explained by increased thyroid-stimulating hormone (tsh-beta). the conversion of t4 to t3 (deiodinase type i-dio1) was decreased, which reduced t ... | 2011 | 22004968 |
| Proximal and distal rectal cancers differ in curative resectability and local recurrence. | To evaluate patients with proximal rectal cancer (PRC) (> 6 cm up to 12 cm) and distal rectal cancer (DRC) (0 to 6 cm from the anal verge). | 2011 | 22007278 |
| our experience in the treatment advanced neoplasms of floor of the mouth. | aim: the aim of this study was to evaluate results of our surgical treatment of advanced neoplasms of the floor of the mouth, treated from 2005-2011 in department of otolaryngology and department of plastic surgery medical university of gdańsk material: we analyzed group of 12 patients (aged 36 to 70 years, mean 55) treated by primary surgical excision of neoplasms of the floor of the mouth (with tracheotomy and mandibulotomy) and selective or radical neck dissection (uni- or bilateral) in combi ... | 2011 | 22078284 |
| prognostic factors (including hpv status) for irradiation of locally advanced squamous cell carcinoma of the head and neck (scchn). | the prognosis of patients with locally advanced squamous cell carcinoma of the head and neck (scchn) is generally poor. however, prognostic factors can help optimize the care for the individual patient. this study investigated potential prognostic factors, including hpv status, for locoregional control (lrc), metastases-free survival (mfs), and survival (os). | 2011 | 21932027 |
| Schistosoma japonicum: treatment of different developmental stages in mice with long-acting praziquantel implants. | This paper reports the effective treatment of Schistosoma japonicum in a mouse model with long-acting praziquantel (PZQ)-loaded poly(e-caprolactone) implants. The implants yielded stable, high plasma PZQ concentrations ranging 100-1600 ng/mL during the 40-day investigation period. For assessment of efficacy, the implants were implanted into mice immediately after infection and at 1, 2, 3 and 4 weeks after infection to treat the schistosomes at different developmental stages. All the mice were sa ... | 2011 | 21856298 |
| Preterm birth and Assisted Reproductive Technology/ART: Maternal emotional wellbeing and quality of mother-newborn interaction during the first three months of life. | OBJECTIVE: Assisted Reproductive Technology (ART) and premature birth are stressful and difficult experiences for women. No research to date has examined the impact of ART on mother-child relationship in instances of preterm delivery. This study explored the psychological status of preterm infants' ART-mothers and the quality of mother-infant dyadic interaction, up to child age of three months (Corrected Age = CA). METHOD: Forty-one ART-dyads and 53 Spontaneous Pregnancy (SP) dyads were enrolled ... | 2011 | 22055247 |
| predictive value of baseline neutrophil/lymphocyte ratio for t4 disease in wall-penetrating gastric cancer. | multimodality therapy has been used in the management of gastric cancer associated with locoregional spread. however, the accurate clinical staging still remains to be established. the neutrophil/lymphocyte ratio (nlr) in the peripheral blood is reported to be an easily assessable prognostic factor in cancer patients. we evaluated the predictive significance of the nlr and other serological parameters in patients with wall-penetrating gastric cancer. | 2011 | 21913135 |
| Thyroid function in childhood obesity and metabolic comorbidity. | Childhood obesity is a worldwide health problem and its prevalence is increasing steadily and dramatically all over the world. Obese subjects have a much greater likelihood than normal-weight children of acquiring dyslipidemia, elevated blood pressure, and impaired glucose metabolism, which significantly increase their risk of cardiovascular and metabolic diseases. Elevated TSH concentrations in association with normal or slightly elevated free T4 and/or free T3 levels have been consistently fou ... | 2012 | 22130312 |
| Genome and proteome of Campylobacter jejuni bacteriophage NCTC 12673. | Campylobacter jejuni continues to be the leading cause of bacterial food-borne illness worldwide, so improvements to current methods used for bacterial detection and disease prevention are needed. We describe here the genome and proteome of C. jejuni bacteriophage NCTC 12673 and the exploitation of its receptor-binding protein for specific bacterial detection. Remarkably, the 135-kb Myoviridae genome of NCTC 12673 differs greatly from any other proteobacterial phage genome described (including C ... | 2011 | 21965409 |
| Cord blood levels of thyroid hormones and IGF-1 weakly correlate with breast milk levels of PBDEs in Taiwan. | In vivo studies indicate that prenatal or neonatal exposure of rodents to polybrominated diphenyl ethers (PBDEs) disrupts thyroid hormone balance, but few studies have reported an association of PBDEs and insulin-like growth factor 1 (IGF-1). The goal was to examine whether PBDEs exposure affects the levels of thyroid hormones and IGF-1 in cord blood. Study participants were healthy pregnant women recruited from the general population in central Taiwan between 2000 and 2001 and in southern Taiwa ... | 2011 | 22088798 |
| complete genomic sequence of a t4-like bacteriophage, phias4, infecting aeromonas salmonicida subsp. salmonicida. | a newly identified virulent phage (named phias4) infecting aeromonas salmonicida subsp. salmonicida was isolated from river water in korea. morphological analysis of phias4 by transmission electron microscopy revealed that it belonged to the family myoviridae. the genome of phias4 comprised a linear double-stranded dna of 163,875 bp with a g + c content of 41.3%, and genomic analysis revealed 271 putative orfs, 67 putative promoters, 25 putative terminator regions, and 16 trna-encoding genes. mo ... | 2011 | 22116495 |
| beef lipids in relation to animal breed and nutrition in argentina. | fatty acid (fa) composition of intramuscular fat (imf) in m. longissimus dorsi (ld) was measured in 72 steers from angus (a), charolais×angus (cha×a) and holstein argentine (ha) breeds. the steers were allotted to four dietary treatments of six animals each: t1, steers grazed on pasture; t2, steers supplemented with cracked corn grain (0.7% of live-weight) daily and free access to pasture; t3, steers supplemented with cracked corn grain (1% of live-weight) daily and free access to pasture; and t ... | 2008 | 22062910 |
| adsorption of viruses on activated carbon. equilibriums and kinetics of the attachment of escherichia coli bacteriophage t4 on activated carbon. | | 1967 | 22148337 |
| vash is a transcriptional regulator of the type vi secretion system functional in endemic and pandemic vibrio cholerae. | the gram-negative bacterium vibrio cholerae is the etiological agent of cholera, a disease characterized by the release of high volumes of watery diarrhea. many medically important proteobacteria, including v. cholerae, carry one or multiple copies of the gene cluster that encodes the bacterial type vi secretion system (t6ss) to confer virulence or interspecies competitiveness. structural similarity and sequence homology between components of the t6ss and the cell-puncturing device of t4 bacteri ... | 2011 | 21949076 |
| Effectiveness and pitfalls of elective neck dissection in N0 laryngeal cancer. | The aim of the study was to evaluate the efficacy and potential pitfalls of selective neck dissection of levels II-IV in controlling occult neck disease in clinically negative neck (cN0) of patients with laryngeal squamous cell carcinoma. Charts of 96 consecutive cN0 laryngeal cancer patients undergoing 122 neck dissections at the University of Florence from January 2000 to December 2004 were reviewed. N0 neck was defined with contrast enhanced computed tomography scan. Occult neck disease rate ... | 2011 | 22058599 |
| Neoadjuvant Chemotherapy in 29 Patients with Locally Advanced Follicular or Hürthle Cell Thyroid Carcinoma: A Phase 2 Study. | Background: It is believed that chemotherapy (ChT) is ineffective in follicular thyroid carcinoma (FTC) and Hürthle cell thyroid carcinoma (HCTC). The aim of our retrospective study was to find out whether neodjuvant ChT before thyroid surgery had any effect on the size of primary tumor in patients with FTC or HCTC. Methods: The study included 29 patients (20 women, 9 men; mean age: 60.8 years) with FTC or HCTC who had T3 or T4 tumor and were treated with neoadjuvant ChT from 1979 to 2004. A m ... | 2011 | 22175241 |
| Geofold: Topology-based protein unfolding pathways capture the effects of engineered disulfides on kinetic stability. | Protein unfolding is modeled as an ensemble of pathways, where each step in each pathway is the addition of one topologically possible conformational degree of freedom. Starting with a known protein structure, GeoFold hierarchically partitions (cuts) the native structure into substructures using revolute joints and translations. The energy of each cut and its activation barrier are calculated using buried solvent accessible surface area, side chain entropy, hydrogen bonding, buried cavities, and ... | 2011 | 22189917 |
| Thrombin generation in severe sepsis. | INTRODUCTION: Hemostasis and inflammation are two tightly interrelated systems in the host's response to infection. Thrombin generation in sepsis plays a crucial role in enhancing and modulation of inflammation. The present study aimed to investigate the course of thrombin generation in patients with severe sepsis, and its correlation with outcome. MATERIALS AND METHODS: Thrombin generation was measured in platelet-poor plasma from 32 healthy controls and 75 patients with severe sepsis using the ... | 2011 | 21872299 |
| Viral Infections in Septic Shock (VISS-Trial)-Crosslinks Between Inflammation and Immunosuppression. | BACKGROUND: Recent investigations provided evidence that herpes simplex virus (HSV-1) and cytomegalovirus (CMV) are reactivated in critically ill individuals. However, at this time, it remains unclear whether these viral infections are of real pathogenetic relevance or represent innocent bystanders. MATERIALS AND METHODS: In total, 60 patients with septic shock were enrolled. Blood samples and tracheal secretion were collected at the time of sepsis diagnosis (T0) as well as 7 d (T1), 14 d (T2), ... | 2011 | 22172138 |
| The incidence of thyroid function abnormalities and natural course of subclinical thyroid disorders, Tehran, I. R. Iran. | Back ground: Despite the high prevalence of thyroid dysfunction, the epidemiology and natural course of these disorders have not yet been identified. Aim: the present survey was conducted to determine the incidence of thyroid dysfunction and natural course of subclinical thyroid disorders in an urban community of Tehran, I. R. Iran. Subjects & Methods: Serum TSH and thyroperoxidase antibody (TPOAb) were measured at baseline and after 6.7 years from a sample of 1999 randomly selected subjects ... | 2011 | 21971483 |
| spinal intradural, extramedullary anaplastic ependymoma with an extradural component: case report and review of the literature. | there have been 18 reported cases of primary spinal intradural, extramedullary ependymomas reported in the literature. one of the 18 cases had an extradural component and was benign. our case is the second spinal intradural, extramedullary ependymoma with an extradural component and the first with its initial presentation as an anaplastic ependymoma. | 2011 | 21918734 |
| treatment with levothyroxine in pregnant rats with subclinical hypothyroidism improves cell migration in the developing brain of the progeny. | aim: this study aims to investigate whether maternal subclinical hypothyroidism (sch) influences the developing brain, and the effect of treatment with levothyroxine in early maternal sch on the progeny's developing brain. material and methods: 75 thyroidectomized female wistar rats were divided randomly into groups of hypothyroidism (ch), sch, sch treated with levothyroxine from embryonic day 10 (e10), e13 and e17 till post-natal day 21. there were 15 sham operated controls. results: pups from ... | 2011 | 22024639 |
| decreased levels of alternative co-stimulatory receptors ox40 and 4-1bb characterise t cells from head and neck cancer patients. | background and aim: head and neck cancers (hnc) are aggressive tumours. tumour-specific t cells are frequently identified in patients with cancer, although they fail to control tumour progression. a family of proteins called co-stimulatory receptors regulate the function of t cells and may account for t cell dysfunction in cancer. our aim was to characterise co-stimulatory receptors on t cells in hnc patients to identify novel targets for immunotherapy. methods: peripheral blood mononuclear cell ... | 2011 | 22204816 |
| expression analysis elucidates the roles of maml1 and twist1 in esophageal squamous cell carcinoma aggressiveness and metastasis. | background: epithelial-mesenchymal transition has recently attracted great attention in studying the malignant progression of cells through a converging pathway of oncogenesis and metastasis. twist1 and mastermind-like 1 (maml1) are major regulators of emt through different pathways. the aim of this study was to investigate the clinicopathological relevance of the expression of maml-1 and twist1 genes in esophageal squamous cell carcinoma (escc). ... | 2011 | 22006371 |
| thyroid autoimmunity in children with coeliac disease: a prospective survey. | thyroid autoimmunity (ta) is often associated with coeliac disease (cd). | 2011 | 21862521 |
| Quality of life and patient satisfaction after video-assisted thoracic sympathicolysis for essential hyperhidrosis: a follow-up of 138 patients. | Abstract Objectives: Essential hyperhidrosis (EH) is defined as excessive functioning of the sudomotor sweat system. Definitive treatment of choice is video-assisted thoracoscopic sympathetic interruption. Success rates are high, but compensatory hyperhidrosis (CH) remains a troublesome side effect. The aim of this study was to document patient satisfaction and side effects at least 6 months after thoracoscopic sympathicolysis. Methods: Between 2001 and 2005, 246 patients underwent bilateral ... | 2011 | 22011277 |
| The population level prevalence and correlates of appropriate and inappropriate imaging to stage incident prostate cancer in the medicare population. | According to guidelines most men with incident prostate cancer do not require staging imaging. We determined the population level prevalence and correlates of appropriate and inappropriate imaging in this cohort. | 2012 | 22088337 |
| Predictors of survival and recurrence after temporal bone resection for cancer. | BACKGROUND: The purpose of this study was to identify factors predictive of outcome in patients undergoing temporal bone resection (TBR) for head and neck cancer. METHODS: This was a retrospective study of 72 patients undergoing TBR. Factors associated with survival and recurrence were identified on multivariable regression. RESULTS: Most tumors were epithelial (81%), commonly (69%) involving critical structures. Cervical metastases were uncommon (6%). Squamous cell carcinoma (SCC) of the extern ... | 2011 | 21953902 |
| Guideline for prophylactic feeding tube insertion in patients undergoing resection of head and neck cancers. | BACKGROUND: Supplementary nutrition is an important aspect of the multidisciplinary management of head and neck cancer patients. In our unit, method of feeding is based on an arbitrary predicted duration of overall treatment (<30 days indicates NG feeding, >30 days prophylactic PEG tube insertion is appropriate). This paper provides a guideline to assist in choosing the feeding method early on to avoid the need for later PEG insertion in those who were initially fed orally or via NG tube. PATIEN ... | 2011 | 22137826 |
| The Prevalence of Undetected Vertebral Fracture in Patients with Back Pain by Dual-Energy X-ray Absorptiometry (DXA) of the Lateral Thoracic and Lumbar Spine. | This is a prospective study. | 2011 | 21892385 |
| effect of different propranolol doses on skeletal structural and mechanic efficiency in an animal model of growth retardation. | objective: to assess in a growth retardation (gr) model the impact of different propranolol (p) doses on anthropomorphometric and biomechanical variables of the appendicular skeleton. materials and methods: twenty-one day-old male wistar rats were divided into the following groups: control (c), c+p3.5 (cp3.5); c+p7 (cp7); c+p10.5 (cp10.5); c+p14 (cp14); ed, ed+p3.5 (edp3.5); ed+p7 (edp7); ed+p10.5 (edp10.5), and ed+p14 (edp14). control animals with/without p were fed a rodent diet ad libitum. gr ... | 2011 | 22094148 |
| biochemical characterization of a structure-specific resolving enzyme from sulfolobus islandicus rod-shaped virus 2. | sulfolobus islandicus rod shaped virus 2 (sirv2) infects the archaeon sulfolobus islandicus at extreme temperature (70°c-80°c) and acidity (ph 3). sirv2 encodes a holliday junction resolving enzyme (sirv2 hjr) that has been proposed as a key enzyme in sirv2 genome replication. the molecular mechanism for sirv2 hjr four-way junction cleavage bias, minimal requirements for four-way junction cleavage, and substrate specificity were determined. sirv2 hjr cleaves four-way dna junctions with a prefere ... | 2011 | 21858199 |
| Preoperative Radiation Therapy for Upper Rectal CancerT3,T4/Nx: Selectivity Essential. | This review explores the current available literature regarding the role of neoadjuvant therapy for upper locally advanced rectal cancers (=10cm-15cm). Although there is a paucity of data evaluating the outcomes of preoperative chemoradiation for upper rectal cancers the authors suggest that T3N0 tumors will not likely benefit from radiation and that treatment of T4N0 should be individualized. | 2011 | 22154165 |
| upregulation of β2-microglobulin expression in progressive human oral squamous cell carcinoma. | the aim of the present study was to investigate β2-microglobulin (β2-m) expression in normal oral mucosa and progressive oral squamous cell carcinoma (oscc) and to assess the clinical significance of β2-microglobulin expression. the study included 10 cases of normal oral mucosa epithelium specimens, 55 cases of primary oscc specimens, and 25 cases of oscc metastasis specimens. immunohistochemistry was used to determine β2-m expression, ... | 2011 | 22211248 |
| patients with adolescent idiopathic scoliosis of lenke type-1 curve exhibit specific pedicle width pattern. | study aim was to find out if patients with lenke type 1 curve exhibit smaller pedicles and specific pedicle width pattern compared with individuals with no scoliosis. | 2011 | 22045200 |
| timing of plasmid cytokine (il-2/ig) administration affects hiv-1 vaccine immunogenicity in hiv-seronegative subjects. | to investigate the potential immunostimulatory effect of interleukin (il) 2 as a human immunodeficiency virus type 1 (hiv-1) vaccine adjuvant, we conducted a study of a plasmid coding for a fusion protein of il-2 and immunoglobulin (il-2/ig). | 2011 | 21940420 |
| A fatal case of Pneumocystis jirovecii pneumonia in a breast cancer patient receiving weekly paclitaxel and trastuzumab. | Pneumocystis jirovecii (formerly carinii) pneumonia (PJP) is an opportunistic infection well-recognized in patients with profound T cell immunodeficiency. It is much less common in patients with solid tumors unless they have other major predisposing factors such as prolonged treatment with corticosteroids or T4 lymphocyte counts of less than 200 cells/mm(3). We present a previously unreported case of fatal PJP in a breast cancer patient with bone metastases who was receiving a first-line treatme ... | 2011 | 21911478 |
| clinicopathological and prognostic role of cyclin d1 in esophageal squamous cell carcinoma: a meta-analysis. | cyclin d1 is one of the most commonly over-expressed oncogenes; however, its role in esophageal squamous cell carcinoma (escc) remains controversial. we conducted a meta-analysis of 20 studies, comprising 2,041 patients to clarify this issue. in all studies, paraffin-embedded surgical specimens were collected and the status of cyclin d1 was determined by immunohistochemistry (ihc). the combined odds ratios (ors) for cyclin d1 expression were 0.74 (95% confidence interval [ci]: 0.58-0.93) for wel ... | 2011 | 22098104 |
| identification of chromosomal breakpoints of cancer-specific translocations by rolling circle amplification and long-distance inverse pcr. | we describe the use of rolling circle amplification and long-distance inverse polymerase chain reaction (ld-pcr) to identify chromosomal breakpoints and fusion genes in cancer cells carrying acquired translocations. this approach produced enough template for 100 inverse pcr reaction from as little as 20 ng of patient dna, consequently enabling the use of up to 500 times less patient dna compared to standard inverse pcr. the method is based on identifying restriction sites in a putative breakpoin ... | 2011 | 21962896 |
| the efficacy and safety of neoadjuvant chemotherapy +/- letrozole in postmenopausal women with locally advanced breast cancer: a randomized phase iii clinical trial. | this two-arm randomized clinical study aimed to evaluate the efficacy and safety of neoadjuvant concurrent chemotherapy and letrozole in postmenopausal women with locally advanced breast carcinoma. one hundred and one postmenopausal women aged 50-83 years with pathologically proven locally advanced (clinical stage t3, t4 and/or n2, n3) breast cancer were randomly assigned to receive neoadjuvant chemotherapy alone (control arm, n = 51) or neoadjuvant chemotherapy concurrent with letrozole 2.5 mg ... | 2011 | 22002564 |
| Prognostic value of preoperative radiological staging assessed by computed tomography in patients with nonmetastatic colon cancer. | Purpose: This study evaluated the prognostic value of preoperative locoregional staging in patients with colon cancer and who underwent curative resection. METHODS: A total of 536 consecutive patients who underwent curative resection for colon cancer from February 1999 to November 2007 were prospectively enrolled. The clinicopathological variables, including the radiological staging using computed tomography, were analyzed for the prognostic significance. RESULTS: The 5-year overall survival r ... | 2011 | 21948813 |
| n-vinylpyrrolidone dimer, a novel formulation excipient, causes hepatic and thyroid hypertrophy through the induction of hepatic microsomal enzymes in rats. | n-vinylpyrrolidone dimer (vpd) is a novel experimental formulation excipient intended for preclinical toxicology studies. in a previous 4-week toxicity study, vpd induced dose-dependent hepatocellular and thyroid gland hypertrophy in sprague-dawley (sd) rats. the objectives of the current investigation were to define the underlying molecular mechanisms of these changes. two separate studies were conducted using male sd rats, daily doses of 300, 1000 or 3,000 mg/kg of vpd, and a positive control ... | 2012 | 22037397 |
| Plasmatic vasopressin in patients undergoing conventional infra-renal abdominal aorta aneurysm repair. | To evaluate plasmatic arginine vasopressin (AVP) levels in patients undergoing scheduled conventional abdominal aortic aneurysm (AAA) repair. | 2011 | 22086577 |
| Restriction enzyme-free construction of random gene mutagenesis libraries in Escherichia coli. | Directed evolution relies on both random and site-directed mutagenesis of individual genes and regulatory elements to create variants with altered activity profiles for engineering applications. Central to these experiments is the construction of large libraries of related variants. However, a number of technical hurdles continue to limit routine construction of random mutagenesis libraries in Escherichia coli, in particular, inefficiencies during digestion and ligation steps. Here, we report a ... | 2011 | 22155067 |
| adenine recognition is a key checkpoint in the energy release mechanism of phage t4 dna packaging motor. | atp is the source of energy for numerous biochemical reactions in all organisms. tailed bacteriophages use atp to drive powerful packaging machines that translocate viral dna into a procapsid and compact it to near-crystalline density. here we report that a complex network of interactions dictates adenine recognition and atp hydrolysis in the pentameric phage t4 large "terminase" (gp17) motor. the network includes residues that form hydrogen bonds at the edges of the adenine ring (q138 and q143) ... | 2011 | 22100308 |
| significant association between thyroid hormones and erythrocyte indices in euthyroid subjects. | objective hypothyroidism and hyperthyroidism are each associated with anaemia, but relationships between thyroid function and erythrocyte indices in euthyroid subjects have not been examined. the aim of this study was to examine these relationships in a community-based cohort. design, subjects and measurements linear regression models with free t4, free t3 and tsh as predictors of erythrocyte indices and serum iron parameters were fitted to data from a cohort of 1179 participants in the 1994 b ... | 2011 | 21913954 |
| Are thyroid hormone concentrations at birth associated with subsequent autism diagnosis? | Thyroid hormones substantially influence central nervous system development during gestation. We hypothesized that perturbations of early thyroid profiles may contribute to the development of autism spectrum disorders (ASD). Thyroid pathways could provide a mechanism by which environmental factors that affect the thyroid system may impact autism occurrence or phenotypic expression. We investigated whether thyroxine (T4) levels at birth are associated with subsequent ASD, using two existing Calif ... | 2011 | 21882364 |
| [Thyreopathy in primary care]. | Thyroid gland disorders, as the core of all endocrinopathies, affect 5-7% of the population of the Czech Republic, with women being affected 6-8 times more often than men. Clinically, thyreopathies are divided into hormonal production disorders and morphology disorders. Thyroid hormones fT3, fT4 and TSH serum levels determine the diagnosis of a thyroid gland disorder. Primary hypothyreosis is characterized by reduced fT4 and increased TSH. Low T3 syndrome is a protective reaction of the organism ... | 2011 | 21957775 |
| [Patient-controlled epidural analgesia combined with patient-controlled intravenous analgesia for postoperative analgesia after miles' operation for rectal cancer]. | A 69-year-old woman (156 cm, 53 kg) underwent a Miles' operation, total hysterectomy, resection of vagina, and thigh flap to vulva for rectal cancer. Before general anesthesia, an epidural catheter was inserted at T11-12 interspace, and 1.5% mepivacaine 7ml was administered. Sensory block level spread from T4 to L1. Anesthesia was induced with propofol and maintained with sevoflurane in air oxygen mixture. Operation was performed uneventfully. After the operation, postoperative analgesia was ach ... | 2011 | 21861422 |
| [Rectal cancer: The radiation basis of radiotherapy, target volume]. | Since the implementation of preoperative chemoradiotherapy and mesorectal excision, the 5-year rates of locoregional failures in T3-T4 N0-N1 M0 rectal cancer fell from 25-30% thirty years ago to 5-8% nowadays. A critical analysis of the locoregional failures sites and mechanisms, as well as the identification of nodal extension, helps the radiation oncologist to optimize the radiotherapy target definition. The upper limit of the clinical target volume is usually set at the top of the third sacra ... | 2011 | 21890393 |
| modulation of the processive abasic site lyase activity of a pyrimidine dimer glycosylase. | the repair of cis-syn cyclobutane pyrimidine dimers (cpds) can be initiated via the base excision repair (ber) pathway, utilizing pyrimidine dimer-specific dna glycosylase/lyase enzymes (pdgs). however, prior to incision at lesion sites, these enzymes bind to non-damaged dnas through charge-charge interactions. following initial binding to dna containing multiple lesions, the enzyme incises at most of these sites prior to dissociation. if a subset of these lesions are in close proximity, cluster ... | 2011 | 21889915 |
| two pathways for rnase e action in escherichia coli in vivo and bypass of its essentiality in mutants defective for rho-dependent transcription termination. | the endonuclease rnase e of escherichia coli is essential for viability, but deletion of its c-terminal half (cth) is not lethal. rnase e preferentially acts on 5'-monophosphorylated rna whose generation from primary transcripts is catalysed by rpph, but δrpph strains are viable. here we show that the rnase e-δcth δrpph combination is lethal, and that the lethality is suppressed by rho or nusg mutations impairing rho-dependent transcription termination. lethality was correlated with defects in b ... | 2011 | 22026368 |
| quality of life in breast cancer survivors: 2 years post self-management intervention. | introduction: today, cancer survivors have an added new role to self manage living with the medical, emotional and role tasks that can affect their quality of life (qol). the purpose of the study was to evaluate the qol of women two years after participating in a self-management intervention program. method: the clinical trial was conducted at university malaya medical centre between 2006 and 2008. the experimental group underwent a 4-week self management program, and the control group underwent ... | 2011 | 22126488 |
| medical image analysis: computer-aided diagnosis of gastric cancer invasion on endoscopic images. | background: the aim of this study was to investigate the efficacy of diagnosing depth of wall invasion of gastric cancer on endoscopic images using computer-aided pattern recognition. methods: the back propagation algorithm was used for computer training. data of 344 patients who underwent gastrectomy or endoscopic tumor resection between 2001 and 2010 and their 902 endoscopic images were collected. the images we ... | 2011 | 22083334 |
| regulation of adiponectin gene expression in adipose tissue by thyroid hormones. | available experimental data suggest that adiponectin and thyroid hormones have biological interaction in vivo. however, the effects of thyroid hormones on adipose adiponectin gene expression in thyroid dysfunction are unclear. we induced hyper- (hyper) and hypothyroidism (hypo) by daily administration of a 12 mg/l of levothyroxine and 250 mg/l of methimazole in drinking water of rats, respectively, for 42 days. the white adipose tissues and serum sample were taken on days 15, 28, 42 and also 2 w ... | 2011 | 22127636 |
| [pharmacological effects of oleum cinnamomi and water extract of cortex cinnamomi in rats with yang-deficiency cold syndrome and the mathematical analysis]. | to compare the effects of oleum cinnamomi and water extract of cortex cinnamomi in rats with yang-deficiency cold syndrome based on mathematical analysis. | 2011 | 21906523 |
| positive correlation between type 1 and 2 iodothyronine deiodinases activities in human goiters. | type 1 (d1) and 2 (d2) iodothyronine deiodinases are selenocysteine-containing enzymes that catalyze the deiodination of t4 to t3 in the thyroid and in peripheral tissues. despite their importance to the plasma t3 pool in human beings, there are few studies about their behavior in human thyroids. in order to better understand iodothyronine deiodinase regulation in the thyroid gland, we studied thyroid tissue samples from follicular adenoma (ad, n = 5), toxic diffuse goiter (tdg, n = 6), nontoxic ... | 2011 | 22207295 |
| differentiated thyroid carcinomas in childhood: clinicopathologic results of 26 patients. | epithelial solid tumors which are rare in childhood are responsible for about 9% of all childhood cancers. however, differentiated thyroid carcinomas (dtcs) are the most common of the endocrine neoplasia (0.5%-3%) in all childhood malignancies. pediatric thyroid cancers have some clinicopathological differences from adult thyroid cancers. this analysis investigates the clinical behavior and pathological characteristics of childhood thyroid cancers, with treatment options and outcomes. a total of ... | 2011 | 22145466 |
| subclinical hypothyroidism and cardiovascular risk: recommendations for treatment. | the definition of subclinical hypothyroidism (sch) is solely biochemical: a serum free t4 level within the reference range in the presence of an elevated serum thyroid-stimulating hormone (tsh) level. while overt hypothyroidism is associated with an increased cardiovascular disease risk, sch, the mildest form of hypothyroidism, may also be associated with an increased cardiovascular disease risk, but to a lesser degree. recent evidence points to a significant trend toward an increase in cardiova ... | 2011 | 21983317 |
| membrane and nuclear permeabilization by polymeric pdna vehicles: efficient method for gene delivery or mechanism of cytotoxicity? | the aim of this study is to compare the cytotoxicity mechanisms of linear pei to two analogous polymers synthesized by our group: a hydroxyl-containing poly(l-tartaramidoamine) (t4) and a version containing an alkyl chain spacer poly(adipamidopentaethylenetetramine) (a4) by studying the cellular responses to polymer transfection. we have also synthesized analogues of t4 with different molecular weights (degrees of polymerization of 6, 12, and 43) to examine the role of molecular weight on the c ... | 2011 | 22175236 |
| effects of adjuvant treatment on cognitive function in women with early breast cancer. | purpose: whether adjuvant therapy impairs cognitive function in women with breast cancer (bc) is unclear. we determined the effects of adjuvant therapy on cognitive function in women with early bc. methods: we consecutively and prospectively enrolled women aged 40-69 years who had a positive radiographic finding from the mammography screening program at stockholm south general hospital. all women completed the headminder web-based neuropsychological battery cognitive stability index (csi) for re ... | 2011 | 21908235 |
| analysis of the seventh edition of american joint committee on colon cancer staging. | purpose: the seventh edition of the american joint committee on cancer (ajcc) staging system has new substages for colon cancer. we used survival data from a single medical center to analyze this new ajcc edition. methods: the colon cancer database of taipei veterans general hospital provided 1,865 patient records covering from 1999 to 2005. survival rates were evaluated using the kaplan-meier method. ... | 2011 | 22146786 |
| factors influencing the outcomes of primary surgery with postoperative radiotherapy for pn2 oropharyneal squamous cell carcinoma. | the purpose of this study was to examine treatment outcomes and define factors that influence survival in patients with pn2 oropharyngeal carcinoma. fifty-five patients underwent primary surgery with postoperative radiotherapy between 1994 and 2009. primary tumor sites were 36 tonsil, 13 base of tongue, 3 soft palate, and three posterior pharyngeal wall. there were 15, 26, 5, and 9 patients with stage t1 to t4 cancers, respectively. the n stage were 5 n2a, 37 n2b, and 13 n2c. the 5-year disease- ... | 2011 | 21924946 |
| estimation of stature from the foot and its segments in a sub-adult female population of north india. | abstract: | 2011 | 22104433 |
| serum tsh level in healthy koreans and the association of tsh with serum lipid concentration and metabolic syndrome. | the proper treatment of subclinical hypothyroidism and the normal range of serum thyroid stimulating hormone (tsh) concentration are intensely debated. however, few reports have investigated tsh concentrations in asian ethnic groups. therefore, the present study was designed to define the tsh reference range in a korean population and to investigate the metabolic significance of tsh concentration. | 2011 | 22205844 |
| diagnostic and prognostic significance of prostate specific antigen and serum interleukin 18 and 10 in patients with locally advanced prostate cancer: a prospective study. | background: prostate cancer is one of the most common cancers afflicting men today. prostate biopsy, an invasive procedure is generally used for diagnoses but attempts are being made to find accurate and precise non- invasive biomarkers. diagnostic accuracy of prostate specific antigen (psa) has been well documented. serum interleukin-18 (il-18) and interleukin-10 (il-10) have shown their diagnostic ability in other cancers but not investigated well in prostate cancer. this study, thus determine ... | 2011 | 22126577 |
| adaptive radiotherapy for head-and-neck cancer: initial clinical outcomes from a prospective trial. | purpose: to present pilot toxicity and survival outcomes for a prospective trial investigating adaptive radiotherapy (art) for oropharyngeal squamous cell carcinoma. methods and materials: a total of 24 patients were enrolled in an institutional review board-approved clinical trial; data for 22 of these patients were analyzed. daily ct-guided setup and deformable image registration permitted serial mapping of clinical target volumes and avoidance structures for art planning. primary site was bas ... | 2011 | 22138459 |
| effects of butachlor on reproduction and hormone levels in adult zebrafish (danio rerio). | butachlor, a chloracetamide herbicide, is widely used in china. in the present study, paired adult male and female zebrafish (danio rerio) were exposed to various concentrations of butachlor (0, 25, 50 and 100μg/l) for 30 days, and the effects on reproduction and endocrine disruption were evaluated using fecundity, condition factor (cf), gonadosomatic index (gsi), liver somatic index (lsi), plasma vitellogenin (vtg), sex steroids and thyroid hormone levels as endpoints. our results showed that t ... | 2011 | 21920721 |
| clinical pathology of greyhounds and other sighthounds. | owing to the development of greyhounds as racing sighthounds, these dogs have acquired unique physiologic adaptations that distinguish them from other breeds. reference intervals for many analytes in retired racing greyhounds (rrgs) differ from those of other breeds; most of the hematologic differences have also been described in other sighthounds. in this review, we provide a survey of the literature on clinical pathology of greyhounds and other sighthounds and results of laboratory testing, in ... | 2011 | 22092909 |
| the c-terminal domain of the adenomatous polyposis coli (apc) protein is involved in thyroid morphogenesis and function. | adenomatous polyposis coli (apc) is a multifunctional protein as well as a tumor suppressor. to determine the functions of the c-terminal domain of apc, we have investigated apc ( 1638t/1638t ) mice, which express a truncated apc that lacks the c-terminal domain. apc ( 1638t/1638t ) mice are tumor free and exhibit growth retardation. in the present ... | 2011 | 22179183 |
| Early Markers of Tubular Dysfunction in Antiretroviral-Experienced HIV-Infected Patients Treated with Tenofovir Versus Abacavir. | Abstract Tenofovir disoproxil fumerate (TDF) is an effective nucleoside reverse transcriptase inhibitor for HIV infection but it is potentially nephrotoxic. A selective mithochondrial toxicity has been hypothesized. To assess early markers of renal toxicity, we evaluated a cohort of antiretroviral (ARV)-experienced HIV patients who had been switched from a thymidinic backbone to either a TDF/emtricitabine regimen (TDF; 73 patients) or an abacavir/lamivudine (ABV) regimen (28 patients). Markers ... | 2012 | 22136504 |
| Combined androgen deprivation therapy and radiation therapy for locally advanced prostate cancer: a randomised, phase 3 trial. | Whether the addition of radiation therapy (RT) improves overall survival in men with locally advanced prostate cancer managed with androgen deprivation therapy (ADT) is unclear. Our aim was to compare outcomes in such patients with locally advanced prostate cancer. | 2012 | 22056152 |
| Long-term skeletal and dental stability of mandibular symphyseal distraction osteogenesis with a hybrid distractor. | The purpose of this study was to examine the long-term skeletal and dental stability of mandibular symphyseal distraction osteogenesis (MSDO) with a tooth-borne and bone-borne hybrid distractor. To differentiate the effects of MSDO from the orthodontic movement and relapse, each phase of treatment was analyzed. | 2012 | 22196186 |
| the surgical management and prognosis of renal cell cancer with ivc tumor thrombus: 15-years of experience using a multi-specialty approach at a single uk referral center. | objectives: surgical management of renal cell carcinoma (rcc) invading the inferior vena cava (ivc) remains a technical challenge. however, radical surgery is the only potentially curative treatment. we set out to review our experience of using a multi-specialty approach to these patients over the last 15 years. patients and methods: fifty patients with rcc and ivc invasion underwent surgery at our institution (mean age: 59 years). tumor thrombus was infrahepatic/levels i and ii: n = 24, intrahe ... | 2011 | 22169073 |
| a phase ii trial of radiation therapy and weekly cisplatin chemotherapy for the treatment of locally-advanced squamous cell carcinoma of the vulva: a gynecologic oncology group study. | objectives: to determine the efficacy and toxicity of radiation therapy and concurrent weekly cisplatin chemotherapy in achieving a complete clinical and pathologic response when used for the primary treatment of locally-advanced vulvar carcinoma. methods: patients with locally-advanced (t3 or t4 tumors not amenable to surgical resection via radical vulvectomy), previously untreated squamous cell carcinoma of the vulva were treated with radiation (1.8gy daily×32 fractions=57.6gy) plus weekly cis ... | 2011 | 22079361 |
| effect of electrical stimulation on quality of tenderstretched chevon sides. | thirty male black bengal goats 5-8 years of age, slaughtered at the kolkata slaughter house, india, by the traditional 'halal' method, were used to assess the effect of electrical stimulation on tenderstretched sides of chevon carcasses. five groups (t1, t2, t3, t4 and t5) were treated with variable voltages of 35, 110, 330, 550, 1100 with fixed 50hz and 10pulses/s for a duration of 3min. different quality parameters, such as, fibre diameter, sarcomere length, water holding capacity (whc), ph, m ... | 2007 | 22063666 |
| grb7 is required for triple-negative breast cancer cell invasion and survival. | triple-negative breast cancer (tnbc) is a heterogeneous disease that is usually associated with poor prognosis, and frequently associated with the basal-like breast cancer gene expression profile. there are no targeted therapeutic modalities for this disease, and no useful biomarkers. high grb7 rna expression levels are associated with an elevated risk of recurrence in patients with operable tnbc treated with standard adjuvant anthracycline and taxane therapy. to determine whether grb7 is involv ... | 2011 | 22005836 |
| positive lymphoscintigraphy (ils) and negative computed tomography for metastatic penile cancer. | penile carcinoma usually occurs in older than 40 years men with an incidence in western communities of 0.5 to 1.6 per 100,000 men per year while in developing countries the rate is much higher in men. extensive lymph node dissection of lymphatic inguinal metastases evident by inguinal lymphoscintigraphy (ils) induces improved overall survival. a 75 years old male with penile squamous cell carcinoma stage pt2n0m0 of less than 2cm diameter, with tumor invasion of the penis corpora underwent parti ... | 2011 | 22087456 |
| a randomized trial comparing postoperative adjuvant chemotherapy with cisplatin and 5-fluorouracil versus preoperative chemotherapy for localized advanced squamous cell carcinoma of the thoracic esophagus (jcog9907). | background: patients with esophageal carcinoma receiving postoperative chemotherapy showed superior disease-free survival than those receiving surgery alone in a japan clinical oncology group trial (jcog9204). the purpose of this study was to evaluate optimal perioperative timing-that is, before or after surgery-for providing chemotherapy in patients with locally advanced esophageal squamous cell carcinoma. methods: eligible patients with clinical stage ii or iii, excluding t4, squamous cell car ... | 2011 | 21879261 |