| delayed posttraumatic propionibacterium acnes endophthalmitis in a child. | a 7-year-old boy presented with granulomatous anterior uveitis after an unrecognized penetrating injury in the same eye 2 months previously. the uveitis was unresponsive to topical corticosteroid therapy, lensectomy with anterior vitrectomy, and administration of intraocular and subconjunctival injections of vancomycin. pars plana vitrectomy, capsulectomy, and injection of intravitreal vancomycin were eventually performed, leading to complete resolution of the intraocular inflammation. culture a ... | 2006 | 16898393 |
| evaluation of cytokines concentration and percentage of survival of rabies virus-infected mice submitted to anti-rabies vero-cell propagated vaccine and p. acnes. | previously, survival of rabies infection was shown to correlate with low il-6 serum concentration in mice subjected to post-exposure treatment with the fuenzalida palacios rabies vaccine in conjunction with the immunomodulator propionibacterium acnes, previously corynebacterium parvum. considering the substitution of the fuenzalida palacios rabies vaccine by the vero cell raised anti-rabies vaccine in almost all countries, the objective of this work was to evaluate the survival and cytokine seru ... | 2006 | 16930720 |
| critical role of toll-like receptors and the common tlr adaptor, myd88, in induction of granulomas and liver injury. | toll-like receptors (tlr) recognize pathogens and regulate innate immune activation. here, we investigated the roles of tlr9 and the common tlr adaptor, myd88, in liver injury. | 2006 | 16935388 |
| sarcoidosis and nod1 variation with impaired recognition of intracellular propionibacterium acnes. | sarcoidosis is a systemic granulomatous disease of unknown etiology. nod2 mutations have been shown to predispose to granulomatous diseases, including crohn's disease, blau syndrome, and early-onset sarcoidosis, but not to adult sarcoidosis. we found that intracellular propionibacterium acnes, a possible causative agent of sarcoidosis, activated nf-kappab in both nod1- and nod2-dependent manners. systematic search for nod1 gene polymorphisms in japanese sarcoidosis patients identified two allele ... | 2006 | 16935475 |
| outbreak of postoperative shoulder arthritis due to propionibacterium acnes infection in nondebilitated patients. | we investigated an outbreak of postoperative shoulder arthritis due to propionibacterium acnes infection in nondebilitated patients. risk factors were male sex, the order in which surgery was performed during the daily operating schedule, and increased duration of the surgical procedure. after modification of the ventilation system and implementation of improved cleaning methods in the operating theater, no new cases were recorded. | 2006 | 16941330 |
| investigation of the mechanism of action of nonablative pulsed-dye laser therapy in photorejuvenation and inflammatory acne vulgaris. | nonablative lasers are widely used for treatment of wrinkles, atrophic scars and acne. these lasers stimulate dermal remodelling and collagen production, but the early molecular stimulus for this is unknown. the mechanism of nonablative lasers in inflammatory acne is variously suggested to be damage either to sebaceous glands or to propionibacterium acnes. their effects on cytokine production are unknown. | 2006 | 16965424 |
| essential roles of dc-derived il-15 as a mediator of inflammatory responses in vivo. | interleukin (il)-15 is expressed in a variety of inflammatory diseases. however, the contribution of dendritic cell (dc)-derived il-15 to the development of diseases is uncertain. using established models of propionibacterium acnes (p. acnes)- and zymosan-induced liver inflammation, we observed granuloma formation in the livers of wild-type (wt) and rag-2(-/-) mice but not in those of il-15(-/-) mice. we demonstrate that this is likely caused by an impaired sequential induction of il-12, ifn-gam ... | 2006 | 16966429 |
| susceptibilities of propionibacterium acnes ophthalmic isolates to ertapenem, meropenem, and cefepime. | we investigated the in vitro susceptibilities of 23 propionibacterium acnes ophthalmic isolates to ertapenem, meropenem, and cefepime by utilizing the etest. the mics ranged from 0.094 microg/ml to 0.75 microg/ml, 0.094 microg/ml to 1.5 microg/ml, and 1 microg/ml to 12 microg/ml for ertapenem, meropenem, and cefepime, respectively. based on our excellent in vitro carbapenem susceptibility results, in vivo studies using ertapenem and meropenem in a rabbit model of p. acnes endophthalmitis are war ... | 2006 | 16971643 |
| treatment considerations for inflammatory acne: clinical evidence for adapalene 0.1% in combination therapies. | acne vulgaris is an exceptionally common, chronic, and recurring disease. it involves multiple etiological factors including follicular hyperkeratinization, increased sebum production, propionibacterium acnes proliferation, and inflammation. presently, oral isotretinoin is the only single agent that is effective against all 4 major pathophysiologic features. however, this drug is also responsible for several serious side effects, including teratogenicity. therefore, it should be used in only the ... | 2006 | 16989194 |
| pharmacological management of sapho syndrome. | the sapho (synovitis, acne, pustulosis, hyperostosis and osteitis) syndrome (sas) includes different skeletal manifestations such as recurrent multifocal osteomyelitis, osteitis and arthritis, which are frequently associated with different forms of skin pustulosis (palmoplantar pustulosis, pustular psoriasis and severe acne). this syndrome is strictly related to the spondyloarthopathies (particularly to psoriatic arthritis) and many sas cases fulfil the classification criteria for the spondyloar ... | 2006 | 16989598 |
| antibiotic resistance in propionibacterium acnes. microbiological and clinical aspects. | | 2006 | 17000123 |
| biofilm formation by bacteria isolated from retrieved failed prosthetic hip implants in an in vitro model of hip arthroplasty antibiotic prophylaxis. | bacterial infection primarily with staphylococcus spp. and propionibacterium acnes remains a significant complication following total hip replacement. in this in vitro study, we investigated the efficacy of gentamicin loading of bone cement and pre- and postoperative administration of cefuroxime in the prevention of biofilm formation by clinical isolates. high and low initial inocula, representative of the number of bacteria that may be present at the operative site as a result of overt infectio ... | 2007 | 17001707 |
| propionibacterium acnes infections after cranial neurosurgery. | propionibacterium acnes (p. acnes) is a relatively avirulent organism that is part of the normal skin flora. most patient isolates are considered contaminants but, in a small subset of patients, particularly in the post-neurosurgery setting, the organism can cause significant infections. we reviewed our experience with the occurrence and management of p. acnes infections after cranial neurosurgical procedures over a five-year period. | 2006 | 17001816 |
| association between the presence of bacterial 16s rna in prostate specimens taken during transurethral resection of prostate and subsequent risk of prostate cancer (sweden). | to study bacterial 16s rna in archival prostate samples from 352 patients with benign prostate hyperplasia (bph) and evaluate whether the presence of bacterial dna was different in those who later developed prostate cancer (n = 171) and in the matched controls that did not progress to cancer (n = 181). | 2006 | 17006718 |
| systemic antibiotic therapy of acne vulgaris. | inflammatory, medium to severe acne vulgaris is treated with systemic antibiotics worldwide. the rationale is an effect on propionibacterium acnes as well as the intrinsic anti-inflammatory properties of these antibiotics. although there are no correlations between the number of p. acnes and the severity of the disease, associations between the degree of humoral and cellular immune responses towards p. acnes and the severity of acne have been reported. exact data on practical use of these compou ... | 2006 | 17010172 |
| isolation of aminopeptidase n genes of food associated propionibacteria and observation of their transcription in skim milk and acid whey. | in this study consensus oligonucleotides pn5/pn3 were designed by aligning the aminopeptidase n genes (pepn) of various actinobacteria and applied to the isolation of the pepn genes of dairy propionibacteria (pab) and closely related species associated with food. this allowed sequencing of a pepn gene region from propionibacterium jensenii lmg 16541. the sequence of this gene was completed by inverse pcr. consensus primer pairs nu1/d1 and nu2/d1 were derived from the alignment of the new sequenc ... | 2007 | 17013549 |
| a case of nodular-type muscular sarcoidosis: findings of imaging, histopathology, and polymerase chain reaction. | we report a case of nodular-type muscular sarcoidosis with no systemic symptoms. thallium-201 scintigraphy showed intense uptake in the muscular lesion mimicking malignant soft tissue tumor. magnetic resonance imaging (mri) demonstrated characteristic signal patterns of peripheral high intensity with central low intensity ("three stripes" pattern). microscopy revealed sarcoid granuloma with typical histopathological characteristics. propionibacterium acnes was detected on polymerase chain reacti ... | 2005 | 17029046 |
| the immunology of propionibacterium acnes and acne. | the majority of recent publications on the immunology of propionibacterium acnes relate to the potential use of the bacterium as an adjuvant or its use in rodent models of human inflammatory disease. these studies have increased the understanding of the potential effects of propionibacterium acnes on cells of the mononuclear phagocyte system. research into the immunology of acne and the role that propionibacterium acnes plays in inflammatory acne has been limited, with efforts being focussed on ... | 1999 | 17035778 |
| [identification of propionibacterium acnes in a case with stage iii pulmonary sarcoidosis involving hepatosplenic disease]. | a 35-year-old woman was admitted to our hospital because of an abnormal chest radiograph. chest x-ray on admission showed multiple small nodular shadows in both lung fields but no bilateral hilar lymphadenopathy (bhl). moreover, abdominal ct showed some nodules in the liver and spleen, and serum ace was slightly increased to 23.3u/l (normal range: 8.3-21.4u/l). transbronchial lung biopsy and liver biopsy resulted in a diagnosis of stage iii pulmonary sarcoidosis with hepatosplenic disease. histo ... | 2006 | 17037406 |
| inhibition of propionibacterium acnes by bacteriocin-like inhibitory substances (blis) produced by streptococcus salivarius. | we report the in vitro inhibition of propionibacterium acnes (p. acnes) by a bacteriocin-like inhibitory substance (blis-like substance) produced by streptococcus salivarius (s. salivarius). bacteriocins are proteinaceous substances produced by bacteria that are capable of inhibiting the growth of similar bacterial strains. unlike classical antibiotics, they have a relatively narrow spectrum of killing activity, resulting in a reduction in the intensity of selection for resistance. these finding ... | 2006 | 17039652 |
| pathological findings in the lens capsules and intraocular lens in chronic pseudophakic endophthalmitis: an electron microscopy study. | the aim of this study was to describe the pathological findings in lens capsules and intraocular lens (iol) studied by scanning and/or transmission electron microscopy (sem and tem, respectively) in a series of four eyes with chronic pseudophakic endophthalmitis (cpe). | 2008 | 17041575 |
| bacteriology of chronic sinusitis and acute exacerbation of chronic sinusitis. | to establish the microbiological characteristics of acute exacerbation of chronic sinusitis (aecs). | 2006 | 17043258 |
| neurological picture. production of oil in a brain abscess caused by propionibacterium acnes. | | 2006 | 17043293 |
| microbial contamination of "in use" bar soap in dental clinics. | bar soap from 18 different dental clinics were investigated for microbial contamination, while it was "in-use". of the 32 samples obtained from the bar soap, 100% yielded positive culture. a total of 8 different genera of organisms were isolated. each bar soap was found to harbor 2-5 different genera of micro organisms. heavily used soap had more micro organisms compared to less used soap. the microbial load of the "in-use" bar soap constituted a mixed flora of gram positive, gram negative, aero ... | 2006 | 17051871 |
| benzoyl peroxide/clindamycin/uva is more effective than fluticasone/uva in progressive macular hypomelanosis: a randomized study. | there is no effective treatment for progressive macular hypomelanosis. recent findings indicate that propionibacterium acnes may play a role in the pathogenesis. | 2006 | 17052490 |
| transfer of bacteria between biomaterials surfaces in the operating room--an experimental study. | bacterial adhesion to and transfer between surfaces is a complicated process. with regard to the success of biomaterials implants, studies on bacterial adhesion and transfer should not be confined to biomaterials surfaces in the human body, but also encompass surfaces in the operating room, where the origin of many biomaterials related infections is found. the purpose of this study was to quantify the transfer of staphylococcus aureus, staphylococcus epidermidis, and propionibacterium acnes from ... | 2007 | 17058211 |
| identification of anaerobic nonsporeforming gram-positive bacilli by biochemical tests and gas-liquid chromatography. | there are many methods to identify anaerobic nonsporeforming bacilli: histological, bacteriological (biochemical test, microsystem api 20 a), serological, cell wall composition analysis, molecular methods and gas-liquid chromatography (glc). a comparison between biochemical tests and gas-liquid chromatography was made in this study for the identification of this group of microorganisms. glc conditions were established with the aid of reference strains. these conditions were then applied to ten s ... | 2001 | 17061569 |
| propionibacterium acnes as a cause of prosthetic valve aortic root abscess. | propionibacterium acnes isolates usually have relatively low virulence and are often classified as contaminants when isolated from blood and tissue cultures. we report a patient with propionibacterium acnes bacteremia and late prosthetic valve endocarditis, complicated by an aortic root abscess. | 2007 | 17065271 |
| inhibition of pathogenic bacterial adhesion by acidic polysaccharide from green tea (camellia sinensis). | an acidic polysaccharide cs-f2 from camellia sinensis was examined to characterize its anti-adhesive effects against pathogenic bacteria, most notably helicobacter pylori, propionibacterium acnes, and staphylococcus aureus. cs-f2 showed marked inhibitory activity against the pathogen-mediated hemagglutination with a minimum inhibitory concentration (mic) between 0.01 and 0.1 mg/ml, which is lower than the previously reported mic values for panax ginseng and artemisia capillaris. the inhibitory e ... | 2006 | 17090112 |
| bacterial diversity in aortic aneurysms determined by 16s ribosomal rna gene analysis. | aortic aneurysms are common vascular conditions that cause considerable morbidity and mortality. understanding of the mechanisms involved in the pathogenesis of the condition remains limited. recently, infection has been suggested as possible contributor in the development of the disease. the aim of the present study was to examine aortic aneurysms for the presence of bacterial dna using polymerase chain reaction (pcr) targeting the 16s ribosomal rna (rrna) gene, followed by cloning and sequenci ... | 2006 | 17098542 |
| blue and red light combination led phototherapy for acne vulgaris in patients with skin phototype iv. | blue light is effective for acne treatment, inducing photodynamic destruction of propionibacterium acnes (p. acnes). this study was designed to investigate the efficacy of combined blue and red light-emitting diode (led) phototherapy for acne vulgaris. | 2007 | 17111415 |
| propionibacter acnes complicating hiv-associated tuberculous pericardial effusion in cameroon. | large pericardial effusions are common in sub-saharan africa. they are most often caused by tuberculosis and are frequently associated with hiv infection. we report on a case of massive pericardial effusion in a 32-year-old hiv-positive male with smear-positive pulmonary tuberculosis. this was found to be colonised by propionibacter acnes, which is normally found in anaerobic skin flora. despite management, including appropriate antibiotic treatment based on culture and sensitivity, the patient ... | 2006 | 17117231 |
| [the influence of amps from hacat keratinocytes on some bacteria strains derived from skin changes]. | the aim of this study was to evaluate antimicrobial activity of protein extracts from hacat cell line against bacterial strains, isolated from clinical materials, obtained from patients with clinical symptoms of acne (propionibacterium acnes) and gas gangrene (clostridium perfringens and sterptococcus pyogenes). reference strain of staphylococcus aureus atcc 25923 also was used. protein extracts from cultured hacat cells were obtained by 3-fold freezing/defreezing cells in dry ice following by c ... | 2006 | 17133910 |
| lasers alleviate acne. | propionibacterium acnes (p. acnes) and sebaceous glands are involved in the pathogenesis of acne. although often effective, traditional therapies can have drawbacks, such as photosensitivity, other toxicities, polypharmacy and frequent dosing. lasers have been studied to seek a solution that may overcome these disadvantages. lasers and other light therapies target the wavelengths of the porphyrins in p. acnes to induce thermal damage that causes the bacterium's destruction. pulsed-dye laser (pdl ... | 2004 | 17134441 |
| bacteraemia in patients with hidradenitis suppurativa undergoing carbon dioxide laser surgery: detection and quantification of bacteria by lysis-filtration. | hidradenitis suppurativa (hs) is a cicatrising and persistent disease of apocrine gland-bearing areas in adults. the severity of this condition varies from a few suppurating lesions to widespread, disabling disease. the aetiology is obscure, but suggested contributory factors include a genetic predisposition, comedones occluding the pilosebaceous apparatus, bacterial infections, and hormonal factors. treatment consists mainly of surgery, while medical therapies serve principally as adjunct thera ... | 2006 | 17135736 |
| alpha-hydroxyacids and carboxylic acids. | the carboxylic acids include alpha-hydroxyacids (ahas), polyhydroxy acids (phas), aldobionic acids (abas), retinoic acid, vitamin c and azelaic acid. they all have therapeutic actions. ahas, phas and abas are organic hydroxyacids, a group of natural and physiological substances which can modulate skin keratinization and increase biosynthesis of dermal components. because of these effects, ahas, phas and abas are therapeutically effective or beneficial for topical treatment of dry skin, rough ski ... | 2004 | 17147560 |
| variable expression of immunoreactive surface proteins of propionibacterium acnes. | despite accumulating data implicating propionibacterium acnes in a variety of diseases, its precise role in infection remains to be determined. p. acnes antigen-specific cd4(+) t cells are present in early inflamed acne lesions and may be involved in the inflammatory response; however, little is known about the specific antigens involved. in this study, b cell and t cell antigens from p. acnes expression libraries were cloned and evaluated and the four predominant proteins identified were invest ... | 2006 | 17159220 |
| re: propionibacterium acnes infections after cranial neurosurgery. can j neurol sci. 2006;33:292-5. | | 2006 | 17168177 |
| light/laser therapy in the treatment of acne vulgaris. | acne vulgaris is one of the most prevalent skin diseases known. as common as this condition is, the social and psychological consequences are limitless. although current treatments are available and include topical or oral antibiotics, it is crucial to develop a less risky and more effective therapy such as light/laser therapy. this article focuses specifically on the benefits of the light/laser treatment on acne vulgaris. porphyrins accumulated in the bacteria, propionibacterium acnes, one of t ... | 2005 | 17168883 |
| nasal antibiotic-resistant propionibacterium acnes carriage in acne vulgaris patients in turkey. | | 2006 | 17169100 |
| biofilm formation by propionibacterium acnes on biomaterials in vitro and in vivo: impact on diagnosis and treatment. | propionibacterium acnes is found increasingly as a cause of delayed infection, usually involving implanted biomaterials. despite susceptibility to common antibiotics, such infections are very difficult to treat and usually require surgical removal of the device. three clinical isolates of p. acnes were assessed for ability to adhere to titanium, surgical steel and silicone, with and without a plasma conditioning film. after adherence, the biomaterials were then incubated for a further 6 days and ... | 2007 | 17187384 |
| activities of four frog skin-derived antimicrobial peptides (temporin-1dra, temporin-1va and the melittin-related peptides ar-23 and rv-23) against anaerobic bacteria. | the activities of two antimicrobial peptides belonging to the temporin family (temporin-1dra from rana draytonii and temporin-1va from rana virgatipes) and two peptides with structural similarity to the bee venom peptide melittin (ar-23 from rana tagoi and rv-23 from r. draytonii) were evaluated against a range of reference strains and clinical isolates of anaerobic bacteria. these peptides were selected because they show broad-spectrum growth inhibitory activity against reference strains of sev ... | 2007 | 17196372 |
| therapeutic blue light: a different ray of light on an age-old problem. | | 2006 | 17199464 |
| in vitro bactericidal effects of 405-nm and 470-nm blue light. | the aim of this study was to determine the bactericidal effect of 405- and 470-nm light on two bacteria, staphylococcus aureus and pseudomonas aeruginosa, in vitro. | 2006 | 17199466 |
| temporal changes in sebum excretion and propionibacterial colonization in preadolescent children with and without acne. | it is generally accepted that the onset of sebum secretion occurs before puberty in boys and girls as a result of increasing androgen output during the adrenarche. propionibacteria are part of the commensal skin flora and, in adults, are found in highest numbers in sebum-rich areas of skin such as the face and upper trunk. previous studies investigating the association between sebum output and propionibacterial population densities have been cross-sectional and have been carried out mainly in ad ... | 2007 | 17199562 |
| the infectivity of sarcoid clinical material and its bacterial content inoculated in cba mice. | sarcoidosis is a multisystemic disorder that is currently viewed as the consequence of chronic immunological response associating genetic susceptibility and specific environmental or transmissible agents. relevant evidence, although conflicting, justifies a concern about the involvement of specific pathogens to disease causation. in this study we assessed the infectivity of sarcoid clinical material, and of the pathogens found in it, to normal cba mice used as a model of an immuno-competent host ... | 2006 | 17203772 |
| incidence, microbiological findings, and clinical presentation of sternal wound infections after cardiac surgery with and without local gentamicin prophylaxis. | sternal wound infection (swi) is a serious complication after cardiac surgery. in a previous randomized controlled trial, the addition of local collagen-gentamicin in the sternal wound before wound closure was found to significantly reduce the incidence of postoperative wound infections compared with the routine intravenous prophylaxis of isoxazolyl-penicillin only. the aims of the present study were to analyse the microbiological findings of the swis from the previous trial as well as to correl ... | 2007 | 17211605 |
| effect of amodiaquine, a histamine n-methyltransferase inhibitor, on, propionibacterium acnes and lipopolysaccharide-induced hepatitis in mice. | we examined whether treatment with amodiaquine, a potent inhibitor of histamine n-methyltransferase protects mice from propionibacterium acnes (p. acnes)-primed and lipopolysaccharide (lps)-induced hepatitis. the subcutaneous injection of amodiaquine (2 and 5 mg/kg) significantly increased the histamine levels in the liver in comparison to saline treated mice. pretreatment with amodiaquine also improved the survival rate of the hepatitis mice, and this improvement was partially associated with t ... | 2007 | 17222819 |
| role of bacterial and host factors in infectious endophthalmitis. | endophthalmitis is a frequent blinding complication of globe-penetrating injury and ocular surgery. the outcome of this intraocular infection depends both on the organism involved and management of the ensuing inflammation. the role of various toxins and bacterial factors in the pathogenesis of this infection is beginning to be delineated, but appears to be organism specific. because of the immune-privileged environment of the eye, principles important in the resolution of infection at extraocul ... | 2007 | 17264502 |
| type 1 cytokine/chemokine production by mouse nk cells following activation of their tlr/myd88-mediated pathways. | it is well established that il-18r- and toll-like receptor (tlr)-mediated signalings share a common signal pathway mediated by signal adaptor, myd88, and that il-18 synergizes with il-12 for ifn-gamma production by nk cells. here, we investigated whether tlr agonists can replace il-18 for production of ifn-gamma by nk cells. freshly isolated nk cells possessed functional lps receptor composed of tlr4/md2 complex and of cd14, and also expressed other various tlrs. hepatic cd3(-)dx5(+) nk cells pr ... | 2007 | 17289654 |
| screening of plant extracts for antimicrobial activity against bacteria and yeasts with dermatological relevance. | there is cumulative resistance against antibiotics of many bacteria. therefore, the development of new antiseptics and antimicrobial agents for the treatment of skin infections is of increasing interest. we have screened six plant extracts and isolated compounds for antimicrobial effects on bacteria and yeasts with dermatological relevance. the following plant extracts have been tested: gentiana lutea, harpagophytum procumbens, boswellia serrata (dry extracts), usnea barbata, rosmarinus officina ... | 2007 | 17291738 |
| progressive macular hypomelanosis: an overview. | progressive macular hypomelanosis (pmh) is a common skin disorder that is often misdiagnosed. various authors have written about similar skin disorders, referring to them by different names, but we believe that all these similar disorders are part of the same entity.pmh is characterized by ill-defined nummular, non-scaly hypopigmented spots on the trunk, often confluent in and around the midline, and rarely extending to the proximal extremities and neck/head region. there is no itch, pain, or pr ... | 2007 | 17298102 |
| resolution of inflammatory acne vulgaris may involve regulation of cd4+ t-cell responses to propionibacterium acnes. | propionibacterium acnes has been strongly implicated in inflammatory acne. however, its role in the disease is unclear. it has been hypothesized that an immune response to p. acnes and/or p. acnes heat shock proteins (hsps) may play a role in the pathogenesis of inflammatory acne. | 2007 | 17300234 |
| acute dehiscence of a valve prosthesis 5 years after implantation. | propionibacterium acnes, a common human skin organism [perry a.l., lambert p.a., under the microscope propionibacterium acnes, lett app microbiol 2006; 42:185-186], mostly considered a contaminant, has rarely been associated with cases of infectious endocarditis [vanagt w.y., daenen w.j., delhaas t., propionibacterium acnes endocarditis on an annuloplasty ring in an adolescent boy, heart 2004; 90:56]. we report on a 48-year old man with a history of mitral valve replacement who acutely developed ... | 2007 | 17320207 |
| deep infection after rotator cuff repair. | currently, there is little information available concerning the outcome of patients with infection after rotator cuff repair. the purpose of this study was to review retrospectively the incidence, clinical presentation, bacteriology, treatment, and outcomes of patients with rotator cuff repair complicated by deep infection. between 1975 and 2003, 39 cases of deep infection after rotator cuff repair were identified in 38 patients. at a final follow-up of 8.2 years (range, 30 months to 19.8 years) ... | 2007 | 17321157 |
| valuable lessons from sapho syndrome. | | 2007 | 17347017 |
| in vitro activity against anaerobes of retapamulin, a new topical antibiotic for treatment of skin infections. | retapamulin is the first agent of the pleuromutilin class formulated as a topical antibacterial for treating skin infections. the aim of this study was to determine the antimicrobial activity of retapamulin by determining the minimal inhibitory concentration (mic) values of this new drug and comparators against a wide range of anaerobic bacteria of human origin. | 2007 | 17350985 |
| antimicrobial susceptibility of strains of propionibacterium acnes isolated from inflammatory acne. | in the last decade, a significant increase in the antimicrobial resistance of clinical specimens of propionibacterium acnes to first line antibiotics used for acne treatment, has been informed in europe and in the usa. no information about strains isolated from latin-american countries is available. the antimicrobial susceptibility of 53 strains of p. acnes isolated from skin specimens of inflammatory acne patients, at the clinical hospital university of chile was tested. all isolates were susce ... | 2006 | 17357569 |
| tumor microenvironment: hypoxia and buffer capacity for immunotherapy. | in recent years, significant progress has been made in the study of tumor biology and anti-tumor immunotherapy. however, the cellular and molecular mechanisms of tumor progression still remain obscure. as we know, tumor microenvironment that can directly influence tumor development and prognosis has attracted much attention of large number of immunologists. accumulated evidence has suggested that tumor microenvironment is in a hypoxic condition, under which immune cells may exhibit distinct func ... | 2007 | 17360127 |
| [anti-microbial therapies for acne vulgaris: anti-inflammatory actions of anti-microbial drugs and their effectiveness]. | the etiology of acne vulgaris is complicated and characterized by two aspects, non-inflammatory and inflammatory mechanisms. the non-inflammatory aspect is represented by follicular occlusion by sebaceous materials and resultant formation of comedo. on the other hand, acne features the continuing occurrence of inflammation, which yields reddish popular or nodular lesions. therefore, acne is not a simple infection with propionibacterium acnes, but subsequent inflammatory changes are the nature of ... | 2007 | 17380730 |
| bacterial contamination of platelet concentrates: results of a prospective multicenter study comparing pooled whole blood-derived platelets and apheresis platelets. | the germs group initiated a prospective multicenter study to assess prevalence and nature of bacterial contamination of pooled buffy-coat platelet concentrates (ppcs) and apheresis platelet concentrates (apcs) by routine screening with a bacterial culture system. | 2007 | 17381623 |
| cardiac magnetic resonance imaging for detection of an abscess associated with prosthetic valve endocarditis: a case report. | propionibacterium acnes is an organism frequently isolated in cultures and often dismissed as a contaminant. a patient with a febrile illness and prosthetic aortic valve was suspected of having infectious endocarditis. magnetic resonance imaging was useful in defining a paravalvular abscess associated with prosthetic valve endocarditis due to propionibacterium acnes that was then successfully surgically repaired. | 2007 | 17389206 |
| biofilm formation by propionibacterium acnes is associated with increased resistance to antimicrobial agents and increased production of putative virulence factors. | propionibacterium acnes plays an important role in the pathogenesis of acne vulgaris, a common disorder of the pilosebaceous follicles. recently, it was suggested that p. acnes cells residing within the follicles grow as a biofilm. in the present study, we tested the biofilm-forming ability of several p. acnes strains in a microtiter plate model. we also evaluated the resistance of biofilm-grown p. acnes towards antimicrobial agents commonly used in the treatment of acne and the production of pu ... | 2007 | 17399956 |
| genome sequence and analysis of a propionibacterium acnes bacteriophage. | cutaneous propionibacteria are important commensals of human skin and are implicated in a wide range of opportunistic infections. propionibacterium acnes is also associated with inflammatory acne vulgaris. bacteriophage pa6 is the first phage of p. acnes to be sequenced and demonstrates a high degree of similarity to many mycobacteriophages both morphologically and genetically. pa6 possesses an icosahedreal head and long noncontractile tail characteristic of the siphoviridae. the overall genome ... | 2007 | 17400737 |
| acute bilateral diffuse corneal opacity in a child. | to report a case of acute bilateral corneal opacity related to bacterial blepharoconjunctivitis. | 2007 | 17413971 |
| propionibacterium acnes: an agent of prosthetic joint infection and colonization. | prosthetic joint infection (pji) can present a diagnostic challenge, especially with slow-growing and poorly virulent bacteria. | 2007 | 17418419 |
| memory cd4 t cells enhance primary cd8 t-cell responses. | cd4 t-cell help is required for optimal memory cd8 t-cell responses. we have found that engaging preexisting cd4 th1, but not th2, memory cells at the time of cd8 t-cell priming results in increased cd8 effector responses to both bacterial and viral pathogens. the enhanced responses are characterized by increased numbers of cytokine-producing, antigen-specific cells. these findings suggest that engaging endogenous memory th1 cells may increase cellular responses in an immunotherapy or vaccinatio ... | 2007 | 17438031 |
| acute deep infection after surgical fixation of proximal humeral fractures. | acute deep infection after open reduction-internal fixation of proximal humeral fractures is uncommon. currently, there are no reported series on the outcomes of patients treated for infection after surgery for proximal humeral fractures. the purpose of this study was to review the frequency, clinical presentation, bacteriology, treatment, and outcomes of patients with such fractures complicated by acute deep infection. between 1993 and 2003, 5 patients with acute deep infection after open reduc ... | 2007 | 17448697 |
| resveratrol inhibition of propionibacterium acnes. | to evaluate the effects of the anti-inflammatory hydroxystilbene, resveratrol, on propionibacterium acnes growth. | 2007 | 17449884 |
| [preoperatively administered flomoxef sodium concentration in aqueous humor]. | we intravenously administered flomoxef sodium (fmox) 0.5-3.5 hours before cataract surgery and measured the concentration of the agent in the aqueous humor to investigate its penetration into the aqueous humor and its efficacy in the prevention of postoperative endophthalmitis. | 2007 | 17461038 |
| intravenous administration of mip-1alpha with intra-tumor injection of p. acnes shows potent anti-tumor effect. | dendritic cells (dcs) play a key role as potent biological adjuvants in anti-tumor host responses. however, dc-based vaccination does not always eradicate tumors effectively. clinical evidence suggests that a strategy to recruit a substantial number of dcs into the tumor mass might provoke proficient anti-tumor immune responses. here we describe that myeloid dcs (mdcs) efficiently accumulate in tumor sites after intravenous injection of recombinant macrophage inflammatory protein (mip)-1alpha wh ... | 2007 | 17466918 |
| propionibacterium acnes vertebral osteomyelitis: seek and ye shall find? | the pathogenic potential of propionibacterium acnes in implant-associated spine infections is increasingly recognized. however, the clinical findings and outcomes associated with this pathogen in nonimplant-associated spine infections are unknown. we retrospectively reviewed nine male patients who met our strict case definition for p. acnes vertebral osteomyelitis to determine whether the laboratory, radiographic, and histopathology found in these infections differs from that typically associate ... | 2007 | 17483730 |
| analysis of anaerobic blood cultures in burned patients. | the utility of anaerobic blood culturing is often debated in the general population, but there is limited data on the modern incidence, microbiology, and utility of obtaining routine anaerobic blood cultures for burned patients. we performed a retrospective review of the burned patients electronic medical records database for all blood cultures drawn between january 1997 and september 2005. we assessed blood cultures for positivity, organisms identified, and growth in aerobic or anaerobic media. ... | 2007 | 17493763 |
| bacterial reduction in infected root canals treated with 2.5% naocl as an irrigant and calcium hydroxide/camphorated paramonochlorophenol paste as an intracanal dressing. | this clinical study investigated the bacterial reduction after instrumentation using 2.5% sodium hypochlorite (naocl) as an irrigant and further interappointment dressing with a calcium hydroxide (ca(oh)(2))/camphorated paramonochlorophenol (cpmc) paste. eleven teeth with primary intraradicular infections and chronic apical periodontitis selected according to stringent inclusion/exclusion criteria followed in the study. bacterial samples were taken before treatment (s1), after chemomechanical pr ... | 2007 | 17509403 |
| genetic homogeneity/heterogeneity of propionibacterium acnes isolated from patients during cardiothoracic reoperation. | following cardiothoracic surgery, deep sternal wound infection (swi) remains one of the most severe complications. recently, propionibacterium acnes has been suspected as an etiological agent of deep swi. however, this bacterium constitutes part of the resident micro-flora of the human skin. consequently, findings of p. acnes in invasive samples are difficult to value. the aims of this study were to develop and optimize a pulsed-field gel electrophoresis (pfge) protocol for p. acnes, in order to ... | 2007 | 17512224 |
| in vitro modulation of tlr-2, cd1d and il-10 by adapalene on normal human skin and acne inflammatory lesions. | the anti-inflammatory mechanisms of adapalene, a synthetic retinoid used for the treatment of acne patients, are partially understood. they seem particularly related to the modulation of the non-specific immunity. recent studies have shown that toll-like receptor (tlr)-2 expression, a receptor of the innate immune system, was increased in acne lesions and could play an essential role in acne-linked inflammation. the aim of our study was to investigate the new mechanisms of the anti-inflammatory ... | 2007 | 17518990 |
| induction of serum il-18 with propionibacterium acnes and lipopolysaccharide in phagocytic macrophage-inactivated mice. | il-18, an important regulator of immune responses, is expressed in activated macrophages and also in nonimmune cells, such as keratinocytes and epithelial cells. increased levels of serum il-18 are reported in patients with a wide variety of diseases, but it is unclear which type of cell is the major source of serum il-18. here, we showed that the administration of liposomes encapsulating clodronate (clo-lip) in mice selectively depleted f4/80(+) phagocytic macrophages in the liver and spleen. s ... | 2007 | 17522234 |
| modulatory effect of killed propionibacterium acnes and its purified soluble polysaccharide on peritoneal exudate cells from c57bl/6 mice: major nkt cell recruitment and increased cytotoxicity. | propionibacterium acnes has been described as a potent adjuvant to immune responses in vitro and in vivo. presently, we analysed the modulation of peritoneal exudate cells (pec) by heat-killed p. acnes or its purified soluble polysaccharide (ps), both injected intraperitoneally in c57bl/6 mice, aiming at their recruitment and cytotoxicity. both treatments induced an increase in macrophages, immature dendritic cells, b1a lymphocytes and nk1.1(+) cd3(+) cells. the bacterium caused a remarkable inc ... | 2007 | 17523946 |
| clinical and microbiological comparisons of isotretinoin vs. tetracycline in acne vulgaris. | the aim of this study was to compare the clinical and microbiological effect on propionibacterium acnes of oral tetracycline plus topical adapalene vs. oral isotretinoin in moderate to severe acne vulgaris. male and female acne patients with moderate or severe inflammatory disease were enrolled and assigned randomly to 6 months of treatment with oral tetracycline hydrochloride plus topical adapalene, or oral isotretinoin, in a controlled, open study. after cessation of oral treatment the antibio ... | 2007 | 17533492 |
| postoperative central nervous system infection: incidence and associated factors in 2111 neurosurgical procedures. | postoperative central nervous system infection (pcnsi) in patients undergoing neurosurgical procedures represents a serious problem that requires immediate attention. pcnsi most commonly manifests as meningitis, subdural empyema, and/or brain abscess. recent studies (which have included a minimum of 1000 operations) have reported that the incidence of pcnsi after neurosurgical procedures is 5%-7%, and many physicians believe that the true incidence is even higher. to address this issue, we exami ... | 2007 | 17554701 |
| microbiology of acute sinusitis of odontogenic origin presenting with periorbital cellulitis in children. | this study was undertaken to evaluate the aerobic and anaerobic microbiology of acute maxillary sinusitis of odontogenic origin presenting with periodontal infection in children. | 2007 | 17561769 |
| linkage between toll-like receptor (tlr) 2 promotor and intron polymorphisms: functional effects and relevance to sarcoidosis. | the intracellular pathogens propionibacterium acnes and mycobacterium tuberculosis have been leading suspects as the cause of sarcoidosis, a systemic disorder characterized by the formation of non-caseating granulomas. toll-like receptor (tlr) 2 is important in the innate immune response against both pathogens, and is therefore of interest in sarcoidosis research. in the present study, three single nucleotide polymorphisms and one dinucleotide repeat polymorphism in the tlr-2 gene were genotyped ... | 2007 | 17565608 |
| propionibacterium acnes contamination in lumbar disc surgery. | previous studies have shown that propionibacterium acnes may be responsible for low-grade infection of the intervertebral discs of patients with severe sciatica. the aim of this study was to prospectively investigate the presence of bacteria in disc fragment samples obtained during surgery for lumbar disc herniation. p. acnes was cultured from disc fragments in two (3.7%) of 54 patients studied. in addition, control cultures taken from ligamentum flavum and muscle from these two patients were al ... | 2007 | 17573158 |
| prevention of transfusion of platelet components contaminated with low levels of bacteria: a comparison of bacteria culture and pathogen inactivation methods. | this study compared the efficacy of bacterial detection with inactivation for reducing the risk associated with transfusion of platelet (plt) components contaminated with low levels of bacteria. | 2007 | 17581146 |
| photodynamic therapy for acne vulgaris: a pilot study of the dose-response and mechanism of action. | acne vulgaris does not always respond to conventional therapy. photodynamic therapy (pdt) has been proposed as a treatment option. the aim of this study was to determine the optimal light dose for effective pdt treatment of acne and to investigate whether pdt reduces sebum excretion and the amount of propionibacterium acnes. fifteen patients (9 men, 6 women, age range 16-44 years, mean age 25 years) with mild to severe acne were enrolled in an open, unblinded study. aminolaevulinic acid cream (2 ... | 2007 | 17598035 |
| effect of adjunctive treatment with intravenously administered propionibacterium acnes on reproductive performance in mares with persistent endometritis. | to determine whether treatment with a preparation of propionibacterium acnes would improve pregnancy and live foal rates in mares with persistent endometritis. | 2007 | 17605673 |
| il-3 is an important differentiation factor for the development of prostaglandin e2-producing macrophages between c57bl/6 and balb/c mice. | we have previously reported that peritoneal and splenic macrophages from th2-dominant balb/c mice produced higher amounts of prostaglandin (pg) e2 than cells from c57bl/6 mice. in this study, we investigated how macrophages from balb/c mice acquire the ability of enhanced pge2 production, using bone marrow-derived macrophages differentiated by m-csf, gm-csf or il-3. there is no strain difference in pge2 production by gm-csf- and m-csf-differentiated macrophages; however, il-3-differentiated macr ... | 2007 | 17628861 |
| propionibacterium acnes and sapho syndrome: a case report and literature review. | to describe the presence of propionibacterium acnes (p. acnes) in a series of patients with sapho syndrome in which a bone biopsy has been carried out and to discuss the results comparing them to the data described in the literature. | 2007 | 17631745 |
| anti-inflammatory activity of sertaconazole nitrate is mediated via activation of a p38-cox-2-pge2 pathway. | sertaconazole nitrate is an antifungal agent that exhibits anti-inflammatory activity; however, the mechanism for this action was unknown. we investigated the cellular mechanisms by which sertaconazole exerts its anti-inflammatory activity in keratinocytes and human peripheral blood mononuclear cells (pbmcs). paradoxically, sertaconazole was found to activate the proinflammatory p38 mitogen-activated protein kinase. treatment with sertaconazole also resulted in the induction of cyclooxygenase-2 ... | 2008 | 17637821 |
| effect of garcinia mangostana on inflammation caused by propionibacterium acnes. | the present study was aimed to investigate the activity of thai medicinal plants on inflammation caused by propionibacterium acnes in terms of free radical scavenging and cytokine reducing properties. p. acnes have been recognized as pus-forming bacteria triggering an inflammation in acne. antioxidant activity was determined by dpph scavenging and nbt reduction assay. the result showed that garcinia mangostana possessed the most significant antioxidant activity and reduced reactive oxygen specie ... | 2007 | 17644272 |
| isomers of conjugated linoleic acids are synthesized via different mechanisms in ruminal digesta and bacteria. | digesta samples from the ovine rumen and pure ruminal bacteria were incubated with linoleic acid (la) in deuterium oxide-containing buffer to investigate the mechanisms of the formation of conjugated linoleic acids (clas). rumenic acid (ra; cis-9,trans-11-18:2), trans-9,trans-11-18:2, and trans-10,cis-12-18:2 were the major cla intermediates formed from la in ruminal digesta, with traces of trans-9,cis-11-18:2, cis-9,cis-11-18:2, and cis-10,cis-12-18:2. mass spectrometry indicated an increase in ... | 2007 | 17644775 |
| clinical considerations in the treatment of acne vulgaris and other inflammatory skin disorders: focus on antibiotic resistance. | propionibacterium acnes is an anaerobic bacterium that plays an important role in the pathogenesis of acne. certain antibiotics that can inhibit p acnes colonization also have demonstrated anti-inflammatory activities in the treatment of acne, rosacea, and other noninfectious diseases. decreased sensitivity of p acnes to antibiotics, such as erythromycin and tetracycline, has developed and may be associated with therapeutic failure. benzoyl peroxide (bpo) is a nonantibiotic antibacterial agent t ... | 2007 | 17649854 |
| community-based study of acne vulgaris in adolescents in singapore. | there are few studies on the prevalence of acne vulgaris among asian teenagers. | 2007 | 17655737 |
| heterologous expression of linoleic acid isomerase from propionibacterium acnes and anti-proliferative activity of recombinant trans-10, cis-12 conjugated linoleic acid. | the linoleic acid isomerase enzyme from propionibacterium acnes responsible for bioconversion of linoleic acid to trans-10, cis-12 conjugated linoleic acid (t10, c12 cla) was cloned and overexpressed in lactococcus lactis and escherichia coli, resulting in between 30 and 50 % conversion rates of the substrate linoleic acid to t10, c12 cla. the anti-proliferative activities of the fatty acids produced following isomerization of linoleic acid by l. lactis and e. coli were assessed using the human ... | 2007 | 17660413 |
| [pulsed dye laser treatment of acne. study of clinical efficacy and mechanism of action]. | acne vulgaris is a multifactorial disease of the pilosebaceous unit characterized by the development of inflammatory (papules, pustules, cysts) and/or non inflammatory lesions (open and closed comedones) that may progress to scars. the increase of bacterial resistances, adverse effects and teratogenicity of retinoids and lack of response to usual therapies have led to investigate new therapeutic alternatives for acne. | 2007 | 17663931 |
| the propionibacterium acnes genome: from the laboratory to the clinic. | the genome of propionibacterium acnes, the microbe presumed to be at least partially etiologic for the development of acne, has recently been decoded. the genome supports long-standing concepts regarding acne pathogenesis, but also demonstrates heretofore unknown and/or unsuspected bacterial properties, which might play a role in disease occurrence. in turn, understanding the genome may lead to new therapeutic avenues, as summarized in this manuscript. | 2007 | 17668523 |
| study results of benzoyl peroxide 5%/clindamycin 1% topical gel, adapalene 0.1% gel, and use in combination for acne vulgaris. | combination therapy is the standard of care in the management of acne vulgaris. it is essential to treat as many aspects of acne pathogenesis as possible. due to increasing insensitivity of propionibacterium acnes to antibiotics, the concomitant use of other topical agents that exhibit other modes of antibacterial and anti-inflammatory activity is integral to the successful treatment of acne. the combination of topical benzoyl peroxide and clindamycin gel has been shown to be more effective than ... | 2007 | 17668527 |
| reimplantation of a glenoid component following component removal and allogenic bone-grafting. | glenoid component loosening has been a leading cause of failure of total shoulder arthroplasty. in the present study, we evaluated the outcome of reimplantation of a new glenoid component following removal of the previous glenoid component and placement of an allograft in order to determine the results, risk factors for an unsatisfactory outcome, and rate of failure associated with this procedure. | 2007 | 17671018 |
| non-cell corynebacterium parvum generated by nanotechnology: a promising immunomodulator with less side effects. | corynebacterium parvum (cp), a kind of immunomodulator, has been well documented in immunotherapy to tumor. however, severe side effects, such as intrahepatic granulomas and scleromas in injected areas, restrict its clinical application. to minimize side effects of cp, a non-cell corynebacterium parvum product (ncpp) was prepared by disposing cp with nanotechnology. in present study, we compared effect of ncpp with that of cp and found: (1) ncpp with non-formaldehyde residue was easy to be absor ... | 2007 | 17673148 |
| modulation of integrins and filaggrin expression by propionibacterium acnes extracts on keratinocytes. | propionibacterium acnes plays an important role in the pathogenesis of acne and it is established that this bacteria is involved in the induction and maintenance of the inflammatory phase of acne. the aim of our work was to determine if p. acnes extracts could modulate integrins and filaggrin in vitro expression by keratinocytes. integrins and filaggrin expression was examined using immunohistochemistry technique both on normal human epiderminal keratinocytes (nhek) and on deep-frozen sections o ... | 2007 | 17684752 |