| primary anaerobic bacterial meningitis caused by propionibacterium acnes. | | 1993 | 8208657 |
| propionibacterium acnes endophthalmitis after staphylococcus epidermidis endophthalmitis. | | 1993 | 8213985 |
| susceptibilities of 428 gram-positive and -negative anaerobic bacteria to bay y3118 compared with their susceptibilities to ciprofloxacin, clindamycin, metronidazole, piperacillin, piperacillin-tazobactam, and cefoxitin. | the susceptibilities of 428 gram-negative and gram-positive anaerobes (including selected cefoxitin-resistant strains) to bay y3118 (a new fluoroquinolone), ciprofloxacin, clindamycin, metronidazole, cefoxitin, piperacillin, and piperacillin-tazobactam were tested. organisms comprised 115 bacteroides fragilis group, 116 non-b. fragilis bacteroides, prevotella, and porphyromonas spp., 40 fusobacteria, 58 peptostreptococci, 48 gram-positive non-spore-forming rods, and 51 clostridia. beta-lactamase ... | 1993 | 8215278 |
| follicular concentrations of azelaic acid after a single topical application. | follicular concentrations of azelaic acid (aza) were determined in vivo using a rapid, non-invasive method, after a single topical application of 20% (w/w) aza cream, in order to establish whether the in vitro antimicrobial effects observed in previous studies are relevant in vivo. preweighed amounts of 20% (w/w) aza cream were applied over demarcated areas on the forehead and back of nine young adults, and samples were taken over a period of 5 h. aza was removed from the skin surface by washing ... | 1993 | 8217752 |
| influence of topical erythromycin preparations for acne vulgaris on skin surface ph. | topical erythromycin is a standard regimen for inflammatory acne vulgaris because of its action against propionibacterium acnes. changes in p. acnes colonization are inducible by long-lasting changes of skin surface ph. therefore, the influence of six erythromycin preparations with approximative ph values of 7.5 (preparation a) to 10.2 (c) on the skin surface ph was evaluated in healthy volunteers using a cross-over design. following a 14-day run-in period, a constant skin surface ph (5.0) was f ... | 1993 | 8219662 |
| in vitro activity of the new quinolone bay y 3118 against anaerobic bacteria. | the in vitro activity of bay y 3118 against anaerobic cocci, propionibacterium acnes, clostridium perfringens, clostridium difficile, bacteroides fragilis, other bacteroides spp. and fusobacteria was determined by an agar dilution method. this activity was compared with that of ciprofloxacin, ofloxacin, piperacillin, cefoxitin, imipenem, clindamycin and metronidazole. bay y 3118, imipenem, clindamycin and metronidazole were the most active agents tested. the in vitro activity of bay y 3118 again ... | 1993 | 8223667 |
| cytokine induction by extracellular products of oral viridans group streptococci. | during an etiological study of kawasaki disease (mucocutaneous lymph node syndrome [mcls]), we found that dominant viridans streptococcal strains on tooth surfaces and in the throat of both mcls patients and non-mcls control children formed erythrogenic and biologically active, extracellular products. in this study, we demonstrated that erythrogenic culture supernatant concentrates of representative strains (two streptococcus mitis and two streptococcus oralis), when injected intravenously, indu ... | 1993 | 8225600 |
| treatment of propionibacterium endophthalmitis. | | 1993 | 8233377 |
| [chlorhexidine digluconate/chlorocresol combination. in vitro study of interactions observed against potential cutaneous strains]. | the interaction type of chlorhexidine digluconate/chlorocresol association (foaming solution dc 102/1, laboratoires pierre fabre médicament) have been studied according to the chess-board method, on microplate, by determining mbc (minimal bactericidal concentrations) (or mfc (minimal fungicidal concentrations)) adjusted to t 72-150 afnor norm (dilution-neutralization, contact 5 mn) and computation of fbc (or ffc) index. trials were carried out against 18 hospital strains (staphylococcus epidermi ... | 1993 | 8233635 |
| immunoregulation of antitumor response; differential secretion of arachidonic acid metabolites by macrophages during stimulation in vitro with bcg and corynebacterium parvum. | the level of arachidonic acid (aa) metabolites in the supernatants of cultured peritoneal exudate cells (pec) were studied under various conditions using bcg and corynebacterium parvum as stimulators. the metabolite levels were analyzed by thin layer chromatography (tlc). the degree of macrophage cytotoxic/cytostatic activity was dependent on the dose and character of stimulators used and the source of macrophages. the application of microcytotoxicity assay for the evaluation of tumor cell lysis ... | 1993 | 8239907 |
| endogenous endophthalmitis caused by propionibacterium acnes. | | 1993 | 8240097 |
| chemical pleurodesis for malignant pleural effusions. | to provide information about available agents for chemical pleurodesis. | 1994 | 8250457 |
| adjuvanticity of dimethyl dioctadecyl ammonium bromide, complete freund's adjuvant and corynebacterium parvum with respect to host immune response to coccidial antigens. | immune response of chickens to eimeria was investigated following immunization with coccidial antigens in combination with various immunological adjuvants. the adjuvanticity of dimethyl dioctadecyl ammonium bromide (dda) was comparable to that of two other adjuvants known to stimulate cell-mediated immunity: complete freund's adjuvant (cfa) and corynebacterium parvum. however, dda is considered less toxic than cfa and appeared to evoke longer-lasting immunity than c. parvum. in general, intramus ... | 1993 | 8257364 |
| mesothelial cell injury caused by pleural leukocytes from rats treated with intratracheal instillation of crocidolite asbestos or corynebacterium parvum. | the pleural and peritoneal mesothelium is a major target in asbestos exposure where mesothelial cell proliferation, exfoliation, and neoplasia have been reported in workers and experimental animals. the objective of this study was to determine the role of pleural leukocytes in mesothelial cell damage caused by asbestos exposure. we therefore investigated detachment and lysis injury to mesothelial cells in vitro induced by leukocytes lavaged from the pleural space of rats exposed, by intratrachea ... | 1994 | 8306950 |
| [anaerobic propionibacterium in opportunistic infections]. | in three cases, two of which regarded exudative pericardium inflammation and one of lung abscess, biopsy revealed negative bacteriological results. blood cultures resulted in culture of anaerobic gram-negative bacteria from propionibacterium genus. precise chemo- geno-taxonomic studies were performed which confirmed generic identification of isolated strains. these were following: in cell wall--l-dap, alanine, glycine, galactose, glucose, mannose; lack if mycolic acids; %gc 58-59. basing on addi ... | 1993 | 8309301 |
| chronic postoperative endophthalmitis following cataract extraction and intraocular lens implantation. report on nine patients. | between 1987 and 1992, nine patients (three men and six women; mean age, 75 years) presented with chronic postoperative endophthalmitis after cataract extraction and intraocular lens (iol) implantation. eight patients were referred from another institution. the interval between iol implantation and the beginning of intraocular inflammation averaged 5.6 months (range, 1-19 months). the referral diagnosis was "toxic lens" syndrome in seven patients. the main clinical findings were a hypopyon in th ... | 1993 | 8312828 |
| preliminary study of a new intraocular method in the diagnosis and treatment of propionibacterium acnes endophthalmitis following cataract extraction. | late endophthalmitis, due to propionibacterium acnes, developed in three patients following uncomplicated extracapsular cataract extraction and posterior chamber intraocular lens (pc-iol) insertion. cultures from the capsular bag yielded p. acnes in all three. with topical anesthesia and through an anterior chamber paracentesis, culture specimens were taken from and clindamycin irrigated into the capsular bag. filtered 100% oxygen was introduced into the anterior chamber in two; the third also r ... | 1993 | 8321509 |
| clinical bacteriology of dacryocystitis in adults. | to better define the spectrum and relative incidence of pathogens causing dacryocystitis in adults, samples of purulent lacrimal sac contents were obtained from 236 patients undergoing dacryocystorhinostomy for a clinical diagnosis of dacryocystitis. positive culture results were obtained in 52.5%. cultures were pure, consisting of a single organism in 71%, and were mixed in 29%. gram-positive organisms were most common, accounting for 64.5% of the isolates. staphylococcus epidermidis, comprisin ... | 1993 | 8323904 |
| lipopolysaccharide-induced cytokine production and mortality in mice treated with corynebacterium parvum. | tumor necrosis factor alpha (tnf-alpha) has been shown to be an important mediator of the lethal effects of endotoxin in several experimental models of septic shock. however, studies with a recombinant human interleukin-1 (il-1) receptor antagonist protein (il-1ra) suggest a role for il-1 as a mediator of septic shock as well. in the present study, we show that mice treated in vivo with corynebacterium parvum are primed for the production of interferon-gamma (ifn-gamma) and exhibit an enhanced c ... | 1993 | 8336076 |
| synthesis of thiazolidine-2-thione derivatives and evaluation of their hepatoprotective effects. | a series of n-(mercaptoalkyl)thiazolidine-2-thiones and their derivatives were synthesized and evaluated for hepatoprotective activities against propionibacterium acnes-lipopolysaccharide (p. acnes-lps)-induced liver injury in mice and in vitro lipid peroxide (lpo) formation in rat liver microsomes. reaction of n-(p-methoxybenzylthioalkyl)cysteine methyl ester (11) with 1,1'-thiocarbonyldiimidazole followed by deprotection gave the corresponding thiazolidine-2-thione derivatives. among the compo ... | 1993 | 8339334 |
| [effects of protein kinase c activator and inhibitor on release of tumor necrosis factor from mouse peritoneal macrophages]. | the effects of protein kinase c (pkc) activator 1-o-tetradecanoylphorbol-13-acetate (tpa) and inhibitor 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (h-7) and quercetin were studied on release of tumor necrosis factor (tnf) from mouse peritoneal macrophages primed with propionibacterium acnes (pa). the results showed that tpa (1-100 ng.ml-1) and lipopolysaccharides (lps) (1-100 ng.ml-1) induced the release of tnf from pa-primed mouse peritoneal macrophages in dose- and time-dependent manners i ... | 1993 | 8352018 |
| [recommendations for treatment of acne vulgaris]. | acne vulgaris is by far the most prevalent of adolescent skin disease, involving 60-80% of the teenage population. by androgen-stimulation the production of sebum is increased and by hyperkeratinisation the canal of the pilosebaceous follicle will be closed, thereby causing formation of comedones. these will get infected with propionibacterium acnes. the treatment of acne vulgaris therefore consists in 4 steps: sebosuppression (with benzoylperoxid), keratolysis (with vitamin a-acid and azelainac ... | 1993 | 8367176 |
| synthesis and pharmacological activities of novel cyclic disulfide and cyclic sulfide derivatives as hepatoprotective agents. | in order to search for anti-hepatitis drugs, we synthesized a series of eight- and nine-membered cyclic disulfides (1) and six- and seven-membered cyclic sulfides (2) and evaluated them for ability to reduce mortality in the model of acute hepatic failure induced by propionibacterium acnes-lipopolysaccharide in mice. compounds 1 were synthesized by oxidative cyclization of the corresponding dithiol derivatives (3) with diethyl bromomalonate or iodine. compounds 2 were prepared from the methyl es ... | 1993 | 8370107 |
| nonheme iron-nitrosyl complex formation in rat hepatocytes: detection by electron paramagnetic resonance spectroscopy. | isolated rat hepatocytes were examined by epr spectroscopy after exposure to inflammatory stimuli (interferon-gamma [ifn-gamma], tumor necrosis factor-alpha [tnf-alpha], interleukin-1 beta [il-1 beta], and lipopolysaccharide [lps]) in vitro, after in vivo immune activation by corynebacterium parvum, and after exposure to .n = o and to nitroprusside (nitroferricyanide), an no-donating nitrovasodilator. hepatocytes exposed to ifn-gamma, tnf-alpha, il-1 beta, and lps demonstrated the appearance of ... | 1993 | 8385904 |
| phagocytosis of antigens by langerhans cells in vitro. | dendritic cells (dc) isolated from lymphoid tissues are generally thought to be nonphagocytic in culture. it has therefore been unclear how these cells could acquire particulate antigens such as microorganisms for initiation of primary immune responses. lymphoid dc derive in part from cells that have migrated from nonlymphoid tissues, such as langerhans cells (lc) of skin. the ability of lc to internalize a variety of particles was studied by electron, ultraviolet, phase, and differential interf ... | 1993 | 8393477 |
| evidence for the absence of hyaluronidase activity in porphyromonas gingivalis. | the aim of the present study was to evaluate the ability of porphyromonas gingivalis to degrade hyaluronic acid. no hyaluronidase activity was detected using a turbidimetric method, whereas a standard plate assay showed a positive reaction for p. gingivalis. we postulated that the high proteolytic activity of p. gingivalis may account for this observation. a modified plate assay was designed to avoid false-positive reactions caused by proteolytic bacteria. the new assay, based on the formation o ... | 1993 | 8394379 |
| [chest drainage combined with intracavitary therapy in neoplastic pleural effusion: comparison of three different protocols]. | twenty-eight patients with malignant pleural effusion observed in a two year period were treated with intrapleural instillation of different substances: tetracycline, corynebacterium parvum and beta-interferon. different results were observed: complete responsiveness (no recurrence of pleural effusion within three months); partial responsiveness (recurrence of moderate pleural effusion within one month after drainage removal); insufficient responsiveness (recurrence of massive effusion within on ... | 1993 | 8398623 |
| inhibition of inflammatory liver injury by a monoclonal antibody against lymphocyte function-associated antigen-1. | when mice were given an i.v. injection of lps 7 days after an i.v. injection of propionibacterium acnes, liver injury and a rapid increase of serum alanine aminotransferase and asparagine acid aminotransferase occurred. the in vivo administration of mab against lfa-1 on days 1, 2, and 3 after the i.v. injection of p. acnes resulted in a potent inhibition of all these dysfunctions. using p. acnes and the lps model, we found that anti-lfa-1 mab protected the mice from p. acnes and lps-induced leth ... | 1993 | 8409459 |
| interaction of propionibacterium acnes with skin lipids in vitro. | propionibacterium acnes is the predominant microbial resident within the pilosebaceous follicles of sebum-rich areas of human skin. this study investigated the effects of known hydrophobic components of sebum on the physiology and nutrition of this microorganism, grown anaerobically at 33 degrees c, under defined conditions using continuous culture techniques. the medium used was chemically defined, comprising eight amino acids, with glucose as the main carbon energy source, and the culture ph w ... | 1993 | 8409917 |
| anaerobic osteomyelitis and arthritis in a military hospital: a 10-year experience. | the methods of collecting, transporting, cultivating, and identifying aerobic bacteria in bone and joint infections have improved markedly since the early 1980s. in addition, many of the anaerobes have been reclassified and renamed. the purpose of this study was to provide more current information regarding the incidence of recovery of anaerobic bacteria from clinical specimens of infected bone and joint. | 1993 | 8420297 |
| recognition of the qa-2k tumor antigen by t cell receptor gamma/delta of an immunopotentiator-induced tumoricidal t cell of mice. | tumor-specific expression of qa-2k antigen coded by the q5k gene on various mouse tumor cells and immunological response of the host mice to the antigen have been demonstrated [seo et al. (1992) j exp med 175: 547; tanino et al. (1992) cancer immunol immunother 35: 230]. the possibility was examined that qa-2 antigen is one of the recognition target molecules of immunopotentiator-induced, h-2-nonrestricted tumoricidal lymphocytes of qa-2-mice. lymphocytes stimulated in vivo with p. acnes or cult ... | 1993 | 8425212 |
| inhibition of corynebacterium parvum-primed and lipopolysaccharide-induced hepatic necrosis in rats by selective depletion of neutrophils using a monoclonal antibody. | to examine whether neutrophils are involved in the pathogenesis of experimental liver dysfunction, we observed the effect of selective in vivo neutrophil depletion by a monoclonal antibody (rp-3) on the pathogenesis of acute experimental hepatic necrosis in rats induced by a preparative injection of heat-killed corynebacterium parvum and a challenging dose of lipopolysaccharide (lps) (positive control group). the serum transaminase titer 8 h after lps injection was reduced by selective depletion ... | 1993 | 8445327 |
| antibiotic resistant propionibacteria in acne: need for policies to modify antibiotic usage. | | 1993 | 8461769 |
| measurement of the intracellular ph of propionibacterium acnes: comparison between the fluorescent probe bcecf and 31p-nmr spectroscopy. | the intracellular ph of the gram-positive skin bacterium propionibacterium acnes was determined using the ph-sensitive fluorescent probe 2',7'-bis-(2-carboxyethyl)-5-(and-6)carboxyfluorescein (bcecf). the probe was introduced into the bacteria using the membrane-permeable acetoxymethyl ester bcecf-am. the intracellular ph of the bacteria was determined by establishing a relation between the fluorescence ratio 505/450 and ph using the ionophore nigericin. to verify the intracellular ph determined ... | 1993 | 8467419 |
| late infection of spinal instrumentation by hematogenous seeding. | six cases of late spinal infection following instrumentation are described. in all cases, there was a delay of at least 10 months between surgery and the clinical development of sepsis. in 5 of the 6 cases, a distant focus of infection could be identified. two patients had active intravenous drug usage, two patients were paraplegic with neurogenic bladders, and one patient had an episode of pyelonephritis secondary to renal calculi two months prior to presentation. in no instance was there any p ... | 1993 | 8470011 |
| [biochemical and physiologic properties of strains of propionibacterium acnes isolated from the rumen of calves and lambs]. | nineteen strains of propionibacterium acnes isolated from the rumen wall of calves and lambs were subjected to examinations. their biochemical characteristics and antibiotic resistance were evaluated while 10 strains were sensitive to all tested antibiotics. urease activity was recorded in 20% of the examined strains with the mean value 3.42 +/- 0.97 nkat/ml/h. proteolytic activity was observed in all the examined strains. the mean value of lactate-dehydrogenase activity was 4.96 +/- 1.01 nkat/m ... | 1993 | 8475617 |
| postoperative propionibacterium endophthalmitis. treatment strategies and long-term results. | postoperative propionibacterium endophthalmitis is a condition characterized by exacerbations and remissions that has often been accompanied by recurrence after treatment. the purpose of this study is to evaluate the efficacy of initial therapies in preventing recurrent endophthalmitis and to assess the safety of intraocular lens (iol) exchange performed during treatment of active endophthalmitis. | 1993 | 8479698 |
| sinusoidal endothelial cell damage by activated macrophages in rat liver necrosis. | massive hepatic necrosis caused by fibrin deposition in the hepatic sinusoids develops with hepatic macrophage activation in rats given endotoxin after administration of heat-killed corynebacterium parvum. targeted cells of such macrophages were investigated. | 1993 | 8482457 |
| [bacterial contamination of the anterior chamber and cataract surgery]. | the authors report the results of bacteriologic cultures of the anterior chamber aspirate after cataract surgery. the results were positive for 15 cases (24%). nine cultures were positive for 27 eyes operated by phacoemulsification and 6 cultures were positive for 35 eyes operated by extracapsular cataract extraction. the origin of these organisms is the normal bacterial flora of the conjunctiva and the inoculum size is very small. the most commonly identified organisms are coagulase-negative st ... | 1993 | 8482794 |
| network of cytokine and arachidonic acid cascade in acute hepatic failure. | when heat-killed propionibacterium acnes (p. acnes) was intravenously injected into mice and 7 days later a small amount of lipopolysaccharide (lps) endotoxin was administered, most of the mice died of massive liver necrosis. in this liver injury model, cytokines, immunomediators, and eicosanoids, inflammatory products, were produced by kupffer cells and liver-infiltrated macrophages, which were thought to participate, directly or indirectly, in the induction of liver cell damage. furthermore, t ... | 1993 | 8486229 |
| modulation of murine hepatic lipase activity by exogenous and endogenous kupffer-cell activation. | deficiency of hepatic lipase (hl) may play a role in the lipoprotein abnormalities in chronic inflammatory states which are characterized by reticuloendothelial-system activation and cytokine release. hl triacylglycerol hydrolase activity was measured in heparin perfusates of livers from autoimmune mrl/lpr mice, which spontaneously develop a condition closely resembling human lupus erythematosis and exhibit spontaneous kupffer-cell activation after 8 weeks of age, as well as from normal mice tre ... | 1993 | 8503853 |
| tetracycline-resistant propionibacteria from acne patients are cross-resistant to doxycycline, but sensitive to minocycline. | antibiotic-resistant propionibacteria are being isolated with increasing frequency from antibiotic-treated acne patients. minimum inhibitory concentrations (mics) of three tetracyclines, extensively used in acne therapy, were determined for 46 resistant and 19 sensitive propionibacteria isolates. sensitive strains were inhibited by < or = 1 microgram/ml of all three tetracyclines. for every resistant strain tested, the mic of tetracycline exceeded that of doxycycline which, in turn, exceeded tha ... | 1993 | 8504049 |
| propionibacterium acnes causing perivalve abscess. | | 1993 | 8518078 |
| isolation and characterization of coaggregation-defective (cog-) mutants of streptococcus gordonii dl1 (challis). | streptococcus gordonii dl1 (challis) bears coaggregation-mediating surface adhesins which recognize galactoside-containing surface polysaccharides on streptococcus oralis 34, streptococcus oralis c104, and streptococcus sm pk509. fifty-nine spontaneously-occurring coaggregation-defective (cog-) mutants of s. gordonii dl1 unable to coaggregate with partner streptococci were isolated. six representative cog- mutants were characterized by their coaggregation properties with four actinomyces naeslun ... | 1995 | 8519477 |
| chronic contained rupture of an abdominal aortic aneurysm complicated by infection and femoral neuropathy. case report. | | 1995 | 8519880 |
| surgical wound infections due to propionibacterium acnes: a study of 10 cases. | ten cases of surgical wound infection in which propionibacterium acnes was probably the aetiologic agent were reviewed; in five the organism was isolated in pure culture. six patients underwent a neurosurgical procedure. the average time for development of infection was 17.5 days (range 1-30 days). all patients were cured by surgical drainage and, in nine cases, with appropriate antimicrobial therapy. in conclusion, p. acnes must be considered as a cause of surgical wound infections especially a ... | 1995 | 8522780 |
| propionibacterium acnes vertebral osteomyelitis following lumbar puncture: case report and review. | | 1995 | 8527576 |
| functional differences between activated and normal rat liver macrophages: lps uptake capacity by flow cytometric analysis in contrast with tnf-alpha release. | activated liver macrophages are considered to play an important role in the development of liver injuries. functional differences between activated and normal rat liver macrophages were investigated. in addition, from the therapeutic point of view, the effects of prostaglandin e1, prostaglandin i2 and e3330 ((2e)-3-[5-(2,3-dimethoxy-6-methyl-1,4- benzoquinoyl)]-2-nonyl-2-propenoic acid) on the functions of liver macrophages were also determined. rat liver macrophages were primed by propionibacte ... | 1995 | 8531595 |
| electron transport chain activity in normal and activated rat macrophages. | the pivotal role played by the macrophage in specific and nonspecific immunity suggests that the physiological status of the macrophage may effect the overall regulation of the host defense system. many studies have evaluated macrophages as effector cells by examining expression of surface markers, cytokine release, or tumor killing in the presence of challenge to host defenses. in this report, the physiological parameter of mitochondrial respiration in freshly isolated rat macrophages is shown ... | 1995 | 8538159 |
| hepatoprotective effect of sy-640, a novel acetamide derivative, on propionibacterium acnes and lipopolysaccharide-induced liver injury in mice. | the hepatoprotective effect of sy-640 on propionibacterium acnes and lipopolysaccharide-induced liver injury in mice and its protective mechanism were examined. oral administration of sy-640, 150 mg/kg once daily for 7 days, significantly inhibited propionibacterium acnes and lipopolysaccharide-induced liver injury, but a single administration was without effect. liver-infiltrating cells (t-lymphocytes and macrophages) play an important role in propionibacterium and lipopolysaccharide-induced li ... | 1995 | 8540770 |
| aerobic and anaerobic microbiology of superficial suppurative thrombophlebitis. | to study the aerobic and anaerobic microbiologic characteristics of superficial suppurative thrombophlebitis. | 1996 | 8546586 |
| antimicrobial evaluation of nadifloxacin (opc-7251), a new topical quinolone, in acne vulgaris. | | 1995 | 8549327 |
| efficacy of a propionibacterium acnes immunostimulant for treatment of chronic staphylococcus aureus mastitis. | this study determined the efficacy of treatment of chronic staphylococcus aureus imi of lactating dairy cows with a biological response modifier consisting of a killed preparation of propionibacterium acnes. fifty-one lactating dairy cows with chronic s. aureus imi on two commercial dairies were enrolled in a controlled, randomized field trial. twenty-four cows received 1 ml of the immunostimulant twice weekly for 4 wk, and the remainder of the cows served as untreated controls. quarter milk sam ... | 1995 | 8550902 |
| intraocular lens removal from eyes with chronic low-grade endophthalmitis. | intraocular lenses (iols) were removed from 11 eyes with chronic low-grade endophthalmitis after cataract extraction to restore useful vision and prevent recurrence. one anterior chamber lens, one iris-supported lens, and nine posterior chamber lenses were removed. in the eyes with posterior chamber lenses, the posterior capsule was intact; total (n = 7) or partial (n = 2) capsulectomy was performed in these eyes. aqueous humor specimens obtained at surgery were positive for bacteria in five eye ... | 1995 | 8551447 |
| acne vulgaris: tricks and treatments. part ii: the benzoyl peroxide saga. | | 1995 | 8565609 |
| sources of arginine for induced nitric oxide synthesis in the isolated perfused liver. | hepatocytes can be stimulated to express high levels of inducible nitric oxide synthase (inos), which utilizes arginine for nitric oxide (no) synthesis. hepatocytes also synthesize and catabolize arginine, an intermediate in the urea cycle, raising the possibility that the urea pathway may provide substrate for hepatic no synthesis. to identify the sources of arginine for inos, we measured the release of no-2 + no-3 and urea in isolated rat livers perfused in a recirculation model with a krebs-h ... | 1995 | 8572217 |
| clinical significance of intracapsular fluid in patients' breast implants. | clinical reports on the incidence and clinical significance of intracapsular fluid are lacking in the literature. it remains unknown whether the presence of intracapsular fluid has any relation to implant infection or colonization. the purpose of this study was to determine the frequency and type of intracapsular fluid, specifically, whether intracapsular fluid causes implant infection, implant rupture, or bacterial colonization. a total of 139 implants from 72 symptomatic patients were entered ... | 1995 | 8579261 |
| stimulation of macrophages with ifn gamma or tnf alpha shuts off the suppressive effect played by pge2. | pge2 has been shown to be able to interfere with various lymphocyte and macrophage functions, but its effects on macrophage activation are still unclear. in this study, carried out on peritoneal macrophages obtained from healthy, tumour-bearing and corynebacterium parvum-treated mice, we demonstrated that pge2 is involved in the down-regulation of macrophage activation, but it cannot exert its inhibiting effect when macrophages are further stimulated with activating cytokines, such as ifn gamma ... | 1995 | 8582790 |
| intracellular ph changes induced in propionibacterium acnes by uva radiation and blue light. | the intracellular ph changes induced in the gram-positive skin bacterium propionibacterium acnes by blue light and uva radiation were studied. two methods (31p nuclear magnetic resonance (nrm) spectroscopy and fluorescence spectroscopy using a ph-sensitive fluoroprobe (2',7'-bis-(2-carboxyethyl)-5-(and -6-)-carboxyfluorescein)) were used to determine the intracellular ph. the ph changes induced by irradiation were found to be a function of cell survival. these changes as a function of cell survi ... | 1995 | 8583280 |
| role of adhesion between activated macrophages and endothelial cells in the development of two types of massive hepatic necrosis in rats. | sinusoidal endothelial cell damage is produced by activation of hepatic macrophages after endotoxin administration in rats pretreated with cornyebacterium parvum or undergoing 70% hepatectomy. such damage causes fibrin deposition in the hepatic sinusoids leading to massive hepatic necrosis. in the c. parvum model, cytotoxic mediators, such as tumour necrosis factor (tnf)alpha and superoxide anions released from activated hepatic macrophages directly destroy sinusoidal endothelial cells. in contr ... | 1995 | 8589340 |
| role of adhesion molecules in the development of massive hepatic necrosis in rats. | massive hepatic necrosis develops after endotoxin administration in rats pretreated with heat-killed propionibacterium acnes as a result of microcirculatory disturbance caused by endothelial cell destruction by activated macrophages in the hepatic sinusoids. immunohistochemical hepatic expression of intercellular adhesion molecule-1 (icam-1) and lymphocyte function-associated antigen 1 alpha (lfa-1 alpha) and the effect of monoclonal antibodies against both adhesion molecules on liver necrosis p ... | 1996 | 8591859 |
| chronic anaerobic bacterial endophthalmitis in pseudophakic rabbit eyes. | experimental anaerobic bacterial endophthalmitis was produced in pseudophakic and aphakic rabbits by using anterior chamber inoculation of 2.5 x 10(6) propionibacterium acnes organisms. clinical inflammation was more intense and prolonged in operated eyes with an intraocular lens in place. the presence of an intraocular lens favors the development of chronic low-grade p. acnes-related inflammation. | 1987 | 8591905 |
| purification, characterization and anti-tumor activity of a new cytokine, histiocyte-secreted-factor (hsf). | purification of cytokines was carried out while monitoring their in vivo anti-tumor activity and in vitro cytotoxic activities. as a result, purified new cytokines were obtained from culture supernatant of a histiocytic cell line from rabbit serum. briefly, a new cytokine (hsf, histiocyte-secreted-factor) was purified from the culture of supernatant of the histiocytic cell line (tyh) which we established from the peripheral blood of a malignant-lymphoma patient. the purified samples exhibited su ... | 1996 | 8603813 |
| novel insight into molecular mechanism of endotoxin shock: biochemical analysis of lps receptor signaling in a cell-free system targeting nf-kappab and regulation of cytokine production/action through beta2 integrin in vivo. | lipopolysaccharide (lps), a constituent of gram-negative bacteria cell wall, plays an essential role in the pathogenesis of septic shock by generating endogenous mediators such as cytokines, nitrous oxide, superoxide anions, and lipid mediators. in vitro, lps induces the transcription of a set of genes involved in inflammatory reactions by activating several types of transcription factors, particularly nuclear factor-kappab (nf-kappab). an analysis of nf-kappab activation using a cell-free syste ... | 1996 | 8603986 |
| distribution of thiols in microorganisms: mycothiol is a major thiol in most actinomycetes. | mycothiol [2-(n-acetylcysteinyl)amido-2-deoxy-alpha-d-glucopyranosyl- (1-->1)-myo-inositol] (msh) has recently been identified as a major thiol in a number of actinomycetes (s. sakuda, z.-y. zhou, and y. yamada, biosci. biotech. biochem. 58:1347-1348, 1994; h. s. c. spies and d. j. steenkamp, eur. j. biochem. 224:203-213, 1994; and g. l. newton, c. a. bewley, t. j. dwyer, r. horn, y. aharonowitz, g. cohen, j. davies, d. j. faulkner, and r. c. fahey, eur. j. biochem. 230:821-825, 1995). since thi ... | 1996 | 8606174 |
| alpha-melanocyte-stimulating hormone reduces endotoxin-induced liver inflammation. | alpha-melanocyte-stimulating hormone (msh) is a potent anti-inflammatory agent in many models of inflammation, suggesting that it inhibits a critical step common to different forms of inflammation. we showed previously that alpha-msh inhibits nitric oxide (no) production in cultured macro-phages. to determine how alpha-msh acts in vivo, we induced acute hepatic inflammation by administering endotoxin (lps) to mice pretreated with corynebacterium parvum, alpha-msh prevented liver inflammation eve ... | 1996 | 8621792 |
| heat-killed corynebacterium parvum enhances endotoxin lung injury with increased tnf production in guinea pigs. | corynebacterium parvum (cp) is known to increase susceptibility to endotoxin, which is associated with increased production of tumor necrosis factor (tnf). we investigated the effect of cp-priming on the pathogenesis of acute lung injury caused by intratracheal escherichia coli endotoxin (lipopolysaccharide [lps]). guinea pigs were divided into four groups: (1) control (n=6), (2) cp-alone (n=6), (3) lps-alone (n=6) and (4) cp + lps (n=6). a cp dose of 4 mg/kg was injected intraperitoneally 7 d b ... | 1996 | 8630544 |
| efficacy and safety of topical azelaic acid (20 percent cream): an overview of results from european clinical trials and experimental reports. | azelaic acid cream (20 percent) is a new topical treatment for acne with an additional therapeutic potential in rosacea and hyperpigmentation disorders. azelaic acid (aza; hooc-(ch2)7-cooh) is a naturally occurring compound that interferes with acne pathogenesis by virtue of its antikeratinizing, antibacterial, and anti-inflammatory properties. vehicle-controlled studies have verified that aza exercises a significant and clinically relevant effect on both non-inflammatory and inflammatory acne l ... | 1996 | 8654128 |
| an overview of acne and its treatment. | the pathophysiology of acne vulgaris results from the interplay of follicular hyperkeratinization, the presence of propionibacterium acnes bacteria in the follicular canal, and sebum production. several anti-acne agents are currently available that affect one or more of these pathogenic factors and are effective against one or more acne lesion types. the only currently available agent that is directly effective against comedones is tretinoin. agents effective against inflammatory lesions include ... | 1996 | 8654131 |
| corynebacterium parvum versus tetracycline as pleural sclerosing agents in rabbits. | tetracycline has been one of the most commonly used agents for producing a pleurodesis. however, it is no longer available due to more stringent requirements on the manufacturing process. the objective of this project was to determine whether corynebacterium parvum is an effective sclerosant in an experimental model in rabbits. the following medications were instilled intrapleurally in anaesthetized male rabbits: tetracycline 35 mg.kg-1 or c. parvum 4 or 8 mg, all diluted with bacteriostatic sal ... | 1995 | 8666113 |
| bacterial contamination of anaerobic vitreous cultures: using techniques employed for endophthalmitis. | to investigate the occurrence of contaminated cultures of vitreous specimens from non-infected eyes obtained using anaerobic techniques employed for endophthalmitis. | 1996 | 8670775 |
| a pivotal role of il-12 in th1-dependent mouse liver injury. | intravenous injection of propionibacterium acnes and lipopolysaccharide (lps) with a 7 day interval caused cd4+ t cell-dependent severe liver injury in the c57bl/6 (h-2b) mouse strain. in contrast, balb/c (h-2d) mice were resistant to p. acnes and lps-induced liver injury. the different susceptibilities of the two mouse strains to liver injury appeared to be closely correlated with their different abilities to produce ifn-gamma after p. acnes priming. namely, the sensitive c57bl/6 mouse strain p ... | 1996 | 8671644 |
| anti-lipase activity of kampo formulations, coptidis rhizoma and its alkaloids against propionibacterium acnes. | anti-lipase activity of kampo formulations, coptidis rhizoma (cr), and its alkaloids against propionibacterium acnes were examined in vitro. the amounts of propionic and butyric acids in the medium were measured as growth and lipase activity of p. acnes, respectively. in tributyrin-pyg medium with each concentration of kampo formulation, cr, or the alkaloids added, the production of propionic acid was suppressed remarkably more than that of butyric acid. the suppression of production of these ac ... | 1996 | 8675819 |
| in vitro activity of mdl 62,879 against gram-positive bacteria and bacteroides species. | the new thiazolyl peptide antibiotic mdl 62,879 (ge2270 a) showed excellent in vitro activity in testing against staphylococci and streptococci, with mic90s ranging from 0.23 to 0.9 mg/l. it was very active against clostridium difficile and propionibacterium acnes (mic90 0.06 mg/l in each case) and had variable activity against bacteroides spp. mdl 62,879 had exceptionally good activity against enterococcus faecalis, including against a collection of high-level aminoglycoside-resistant isolates ... | 1995 | 8681991 |
| fluorescence photography in the evaluation of acne. | quantification of acne remains a challenge. it may be difficult to identify lesions by standard flash photography. previous studies have shown that foci of light in fluorescence photographs correspond to high protoporphyrin ix production by propionibacterium acnes in open comedones, follicles, and inflammatory lesions. | 1996 | 8682965 |
| [current treatment strategy in malignant pleural effusion]. | malignant pleural effusions are a grave consequence of advanced cancer disease. the successful suppression of pleural fluid reaccumulation can make a major contribution to the management and palliative care of patients with disseminated cancer. many treatment concepts have been reported in the literature. the recommended therapy in malignant pleural effusions consists of intrapleural instillation of a sclerotic agent to produce pleurodesis. different substances have been used, including tetracyc ... | 1996 | 8686317 |
| singlet oxygen (1 delta g) generation from coproporphyrin in propionibacterium acnes on irradiation. | although singlet oxygen has been postulated to be a highly reactive and toxic intermediate, there has been no evidence of considerable generation of singlet oxygen in vivo level except for special cases. in this work, we firstly measured the near-infrared emission spectra corresponding to the o2(1 delta g) --> o2(3 epsilon g-) transition of singlet oxygen of cutaneous propionibacterium acnes (p. acnes) porphyrin under laser excitation. a comparison of the singlet oxygen production of coproporphy ... | 1996 | 8687438 |
| salivacin 140, a novel bacteriocin from lactobacillus salivarius subsp. salicinius t140 active against pathogenic bacteria. | fifteen of 353 environmental isolates of lactic acid bacteria consistently showed activity against listeria monocytogenes, streptococcus mutans, actinomyces viscosus, and/or propionibacterium acnes. strain t140, isolated from the surface of japanese pampas grass leaves and identified as lactobacillus salivarius subsp. salicinius, also had activity against several lactobacillus species, staphylococcus aureus and yersinia enterocolitica. since the antagonistic factor(s) produced by t140 was sensit ... | 1996 | 8695066 |
| effect of silica treatment on resistance to babesia rodhaini infection in immunized mice. | the effect of silica treatment on the course of babesia rodhaini infection was investigated in icr mice pretreated with either a mixture of b. rodhaini parasitized red blood cell hemolysation-sonication (s) antigen and propionibacterium acnes bacterin or p. acnes bacterin alone and not subjected to immunization. in the normal mice (non-immunized), the mean survival time was decreased by approximately 1 day when 5 mg per mouse of silica were intraperitoneally inoculated at 5 h before infection. i ... | 1996 | 8720558 |
| oxytetracycline-mediated alteration of murine immunocompetence. | the immunomodulatory effect of oxytetracycline (otc) on murine splenic lymphocytes (msl), peritoneal exudate macrophage (pem) functions and antibody production was examined. in vivo exposure to otc slightly delayed initiation of antibody formation during the primary response. however, otc exposure had no effect on either the peak time of antibody response or peak antibody titer. otc also had no significant effect on the secondary antibody response. mitogen-induced proliferation of msl cocultured ... | 1995 | 8724209 |
| [positive corneal findings of propioni bacterium acnes and keratitis]. | propioni bacterium acnes may be isolated from corneal specimens. its presence usually evokes a neighbouring tissue contamination. nevertheless we have tried to find arguments in favour of a possible pathological responsibility of this microorganism in corneal affections. | 1996 | 8729835 |
| [search for bacterial contamination of the aqueous humor during cataract surgery with and without local antibiotic prophylaxis]. | bacterial contamination of anterior chamber at the end of cataract surgery, was compared between two techniques: extracapsular extraction and phacoemulsification. the effectiveness of preoperative antibiotic eyedrops using norfloxacine 0.3% (chibroxine) was also evaluated. | 1995 | 8745762 |
| rapid formation of multicellular spheroids composed of propionibacterium acnes pretreated adult rat liver cells by rotary culture and their immunological properties. | an experimental acute liver injury model can be produced by the injection of bacterial lipopolysaccharide (lps) into propionibacterium acnes (p. acnes) pretreated rats. the massive liver cell necrosis is estimated by elevation of serum transaminase activities. in this study, we produced this necrosis in an in vitro model by using primary co-cultured rat liver cells. a novel method for the preparation of spheroids consisting of p. acnes pretreated parenchymal and nonparenchymal liver cells has be ... | 1995 | 8746484 |
| protective effects of macrophage-derived interferon against encephalomyocarditis virus-induced diabetes mellitus in mice. | the involvement of macrophages in protection against diabetes mellitus in mice of balb/c (susceptible) and c57bl (resistant) strains infected with the b (non-diabetogenic) or d (highly diabetogenic) variant of encephalomyocarditis (emc) virus was examined. pretreatment with the b variant of emc virus (emc-b), avirulent interferon (ifn) inducer, or corynebacterium parvum inhibited diabetes in balb/c mice infected with the d variant of emc virus (emc-d). treatment of c57bl mice with carrageenan to ... | 1995 | 8746525 |
| [sepsis following autologous blood transfusion]. | postoperatively, after an uncomplicated vaginal hysterectomy, a 58-year-old female patient developed the signs of disseminated intravascular coagulation and fever, which progressed to a septic shock. she received two units of autologous blood, one during and one after the operation. a blood culture from the patient and one unit of the autologous blood showed abundant growth of pseudomonas cepacia and serratia marcescens within 24 h and culture of this blood bag also showed slight growth of staph ... | 1996 | 8779406 |
| immunohistochemical localization of nitric oxide synthases. | | 1996 | 8782617 |
| bacteria and antimicrobial agents in the treatment of acne. | | 1996 | 8786181 |
| microbiology of acute purulent pericarditis. a 12-year experience in a military hospital. | to study the aerobic and anaerobic micro-biological and clinical characteristics in 15 cases of acute pericarditis treated over a 12-year period. | 1996 | 8790081 |
| iron chelates bind nitric oxide and decrease mortality in an experimental model of septic shock. | the hydroxamic acid siderophore ferrioxamine b [feiii(hdfb)+] and the iron complex of diethylenetri-aminepentaacetic acid [feiii(dtpa)2-] protected mice against death by septic shock induced by corynebacterium parvum + lipopolysaccharide. although feiii(dtpa)2- was somewhat more effective than feiii(hdfb)+, the iron-free ligand h4dfb+ was significantly more effective than dtpa. the hydroxamic acid chelator has a much higher iron affinity than the amine carboxylate, allowing for more efficient fo ... | 1996 | 8799167 |
| postoperative subdural empyema caused by propionibacterium acnes--a report of two cases. | two patients with postoperative subdural empyema following burr hole evacuation of chronic subdural haematoma are reported, both caused by propionibacterium acnes. the need to consider this diagnosis in patients developing recurrent symptoms after surgical drainage of chronic subdural haematoma is emphasized. | 1996 | 8799549 |
| coexpression of interleukin-4 and b7.1 in murine tumor cells leads to improved tumor rejection and vaccine effect compared to single gene transfectants and a classical adjuvant. | to improve the vaccine potency of gene-modified tumor cells, using retroviruses, we have expressed the b7.1 gene in j558l cells and a subline previously transfected with the gene for interleukin-4 (il-4). complete longterm tumor eradication occurred in only 73-82% of syngeneic balb/c mice injected with il-4 or b7.1 transfectants or tumor cells mixed with the adjuvant corynebacterium parvum. in contrast, none of the mice injected with j558-il4/b7.1 cells developed a tumor, thus demonstrating that ... | 1996 | 8800747 |
| susceptibility testing of propionibacterium acnes comparing agar dilution with e test. | propionibacterium acnes has been identified as a significant agent of nosocomial infections, including endophthalmitis. data concerning susceptibility of p. acnes to newer beta-lactam antibiotics and fluoroquinolones are limited. recent reports suggest that quinolones have activity against these organisms sufficient to warrant further study. we undertook a study to select appropriate antimicrobial agents for use in a rabbit model of p. acnes endophthalmitis. we compared the antibiotic susceptibi ... | 1996 | 8815076 |
| failure of gram stain to detect propionibacterium acnes in specimens from clinically significant infections. | | 1996 | 8818915 |
| propionibacterium acnes isolated from sternal osteitis in a patient with sapho syndrome. | a woman presented with palmar pustulosis and deep chest pain in association with osteitic lesions in the lower part of the sternum. propionibacterium acnes was isolated and grew in pure culture from 6 surgically obtained bone specimens. the patient received clindamycin treatment for 6 months. synovitis in both her wrists persisted and, based on a clinical suspicion of seronegative rheumatoid arthritis, she was treated with intramuscular gold and methotrexate with no apparent benefit. subsequentl ... | 1996 | 8823714 |
| critical comments on "propionibacterium acnes in the cortex of patients with alzheimer's disease" by h.h. kornhuber (eur arch psychiatry clin neurosci, 1996, 246:108-109) | | 1996 | 8832202 |
| role of ifn gamma on tnf alpha, il-1 beta and il-6 release during hhv-6 infection. | the release of monokines such as tumor necrosis factor a (tnf alpha), interleukin-1 beta (il-1 beta) and interleukin-6 (il-6) by activated monocytes/macrophages is an important step in the immune as well as in the inflammatory response. in this study the production of tnf alpha, il-1 beta and il-6 by human monocytes (hm) and peripheral blood mononuclear cells (pbmc) was evaluated after hhv-6 infection. our results demonstrate that hhv-6 can selectively regulate monokine synthesis, in a time-depe ... | 1996 | 8841033 |
| orbital infections in patients with human immunodeficiency virus infection. | opportunistic infections frequently involve the anterior and posterior segments of the eye but rarely occur in the orbit in patients with human immunodeficiency virus (hiv) infection. the authors managed eight patients with hiv and unilateral orbital infections who presented between july 1988 and march 1995. | 1996 | 8841310 |
| infection of a total knee joint prosthesis by peptostreptococcus micros and propionibacterium acnes in an elderly ra patient: implant salvage with longterm antibiotics and needle aspiration/irrigation. | we describe the favourable long-term outcome after late total knee joint prosthesis infection in an elderly ra patient. peptostreptococcus micros and propionibacterium acnes were cultured from the synovial fluid, and the finding of a coexistent abscess at the root of a wisdom tooth suggested a dental origin to the joint infection. long-term antibiotics in conjunction with aspiration/irrigation resulted in salvage of the implant and an excellent functional outcome. | 1996 | 8853177 |
| protective effect of celosian, an acidic polysaccharide, on chemically and immunologically induced liver injuries. | hepatoprotective effect of celosian, an acidic polysaccharide isolated from the water extract of the seed of celosia argentea, was investigated using chemical and immunological liver injury models. celosian inhibited the elevation of serum enzyme (gpt, got, ldh) and bilirubin levels on carbon tetrachloride (cc1(4))-induced liver injuries in rat. in addition, the hepatoprotective effect of celosian was also observed in this model of liver injury by histopathological findings. moreover, celosian s ... | 1996 | 8860960 |
| experimental extrinsic allergic alveolitis and pulmonary angiitis induced by intratracheal or intravenous challenge with corynebacterium parvum in sensitized rats. | extrinsic allergic alveolitis and pulmonary sarcoidosis are granulomatous diseases of the lung for which clinical presentation and anatomic site of granuloma formation differ. extrinsic allergic alveolitis is caused by inhaled antigens, whereas the nature and source of the inciting antigen in sarcoidosis is unknown. to test the hypothesis that the route via which antigen is introduced to the lung contributes to the clinicopathological presentation of pulmonary granulomatous disease, rats immuniz ... | 1996 | 8863677 |