| effect of menstrual cycle variation in female sex hormones on cellular immunity and regulation. | ovarian steroid hormones reduce cell-mediated immunity (cmi), perhaps by increasing regulatory t cells. we examined the relationship of estrogen and progesterone plasma concentrations during the menstrual cycle with circulating regulatory t cells (treg cells) and with varicella-zoster virus (vzv)-specific lymphocyte proliferation (vzv-lpa). twenty healthy and 20 hiv-infected women were tested at 1-4, 10-14, and 20-24days of the menstrual cycle. hiv-infected women experienced significant increase ... | 2011 | 21429588 |
| single tube multiplex real-time pcr for the rapid detection of herpesvirus infections of the central nervous system. | human herpesvirus infection of immunocompromised hosts may lead to central nervous system (cns) infection and diseases. in this study, a single tube multiplex real-time pcr was developed for the detection of five herpesviruses (hsv-1, hsv-2, vzv, ebv and cmv) in clinical cerebrospinal fluid (csf) specimens. two primer pairs specific for the herpesvirus polymerase gene and five hybridization probe pairs for the specific identification of the herpesvirus types were used in a lightcycler multiplex ... | 2011 | 21466846 |
| detection of follicular fluid and serum antibodies by protein microarrays in women undergoing in vitro fertilization treatment. | a protein microarray serological assay was used to assess the antibody profile of 102 women subjected to in vitro fertilization treatment. the studies were conducted on pairs of serum and follicular fluid samples, collected from each woman on the same day at the time of oocyte recovery. the samples, stored as frozen aliquotes, were assessed by both microarray and elisa. follicular fluids and sera were screened to detect the presence of specific igg and igm antibodies against seven vertically tra ... | 2011 | 21477867 |
| teaching neuroimages: mri findings in varicella zoster brachial plexus neuritis. | | 2011 | 21482943 |
| natalizumab and hsv meningitis. | natalizumab (tysabri, biogen idec and elan pharmaceuticals) is a monoclonal antibody approved for use in patients with relapsing multiple sclerosis (ms) as well as moderate to severe crohn's disease. we report the first case of a patient with a history of ms, on monthly natalizumab, who developed hsv-2 meningitis. we discuss the mechanism of action of natalizumab and review what is known about the reactivation of herpes infection in association with this medication. the question of herpes simple ... | 2011 | 21487835 |
| identification of herpesvirus types 1-8 in oral cavity of children/adolescents with chronic renal failure. | j oral pathol med (2011) the aim of this investigation was to identify the prevalence of herpesvirus types 1-8 in the oral cavity of subjects with chronic renal failure (crf) and healthy subjects and compare the two groups, and also correlate the presence of the virus with some characteristics of crf disease (the type of treatment, drugs administered for crf and the presence of oral manifestations). the sample was made up of 60 subjects (aged 4-20) divided into the renal group (rg) and healthy g ... | 2011 | 21501230 |
| varicella zoster virus infection of neurons derived from human embryonic stem cells: direct demonstration of axonal infection, transport of vzv and productive neuronal infection. | study of the human neurotrophic herpesvirus varicella zoster virus (vzv) and its ability to infect neurons has been severely limited by strict viral human tropism and limited accessibility of human neurons for experimentation. human embryonic stem cells (hesc) can be differentiated to all the cell types of the body including neurons and are therefore a potentially unlimited source of human neurons to study their interactions with human neurotropic viruses. we report here reproducible infection o ... | 2011 | 21525353 |
| differences between the varicella vaccines; using dabigatran. | | 2011 | 21534377 |
| molecular analysis of varicella vaccines and varicella-zoster virus from vaccine-related skin lesions. | to prevent complications that might follow an infection with varicella-zoster virus (vzv), the live attenuated oka strain (v-oka) is administered to children in many developed countries. three vaccine brands (varivax from sanofi pasteur msd; varilrix and priorix-tetra, both from glaxo-smith-kline) are licensed in germany that have been associated both with different degrees of vaccine effectiveness and adverse effects. to identify genetic variants in the vaccines that might contribute to rash-as ... | 2011 | 21562115 |
| chronic virus infections supress atopy but not asthma in a set of children from a large latin american city: a cross-section study. | abstract: background: the prevalence of allergic diseases has increased over recent decades in affluent countries, but remains low in rural populations and some non-affluent countries. an explanation for these trends is that increased exposure to infections may provide protection against the development of allergy. in this work we investigated the association between exposure to viral infections in children living in urban brazil and the prevalence of atopy and asthma. methods: school age childr ... | 2011 | 21569568 |
| efficacy of continuous, daily, oral, ultra-low-dose 200 mg acyclovir to prevent herpes zoster events among bortezomib-treated patients: a report from retrospective study. | objective: herpes zoster is the most common infection in patients treated with bortezomib-containing regimens for multiple myeloma. some clinical trials have reported on the use of acyclovir prophylaxis to decrease the incidence of herpes zoster. however, the appropriate acyclovir dose and duration of prophylaxis remain unclear. the primary objective of this study was to evaluate the efficacy of continuous oral 200 mg/day acyclovir prophylaxis and the secondary objective was to determine the ris ... | 2011 | 21616919 |
| alphaherpes viral genes and their functions | in this chapter the emphasis
is on viral replication and on the viral gene products that define the outcome of
the interaction of the alphaherpesviruses with their host. viral replicative and
host management functions account for some of the rnas and a large number of
proteins encoded by the viruses. there are, however, numerous viral gene products
whose functions have not been identified or which do not play a prominent role in
viral replication in the systems in which t ... | 2007 | 21348062 |
| vsv: persistence in the population | like other herpes viruses, varicella zoster virus (vzv)
causes disease due to the primary infection (varicella) and due to reactivation
(herpes zoster). however, vzv differs from other herpes viruses in causing primary
and reactivation infections that are easily recognized clinical diseases, even by
the lay public. because of this, the epidemiology of varicella and herpes zoster has
been well described from clinically recognized disease (incidence, severe disease
outcomes ... | 2007 | 21348065 |
| vzv: molecular basis of persistence (latency and reactivation) | primary infection with varicella-zoster virus (vzv) causes
varicella manifested by fever and a vesicular rash. during primary infection the
virus disseminates in lymphocytes to the skin and other organs, and replicates in
and establishes a latent infection in the nervous system (croen et al., 1988). early studies demonstrated viral dna in human trigeminal and dorsal
root ganglia by in situ hybridization and southern blotting (gilden et al., 1983, 1987; hyman et al., 1983). more r ... | 2007 | 21348068 |
| acute lymphoblastic leukemia complicated with varicella zoster virus meningoencephalitis and visceral dissemination after related bone marrow transplantation. | meningitis or encephalitis by varicella-zoster virus (vzv) after hematopoietic stem cell transplantation (hsct) is rarely reported. we encountered a case of meningoencephalitis with vzv re-activation 18 months after related bone marrow transplantation for recurrent acute lymphoblastic leukemia. the patient had been administered steroid and cyclosporine for chronic graft-versus-host disease. a high dna copy number of vzv, 4.9×10(7) copies was detected in the cerebrospinal fluid. vzv also caused s ... | 2011 | 21646775 |
| the shingles vaccine. question: if you've had shingles, should you get the vaccine to protect yourself from getting it again? | | 2011 | 21649970 |
| expression of hsv-1 encoded mirnas in human trigeminal ganglia and their relation to local t-cell infiltrates. | herpes simplex type-1 (hsv-1) is a neurotropic virus which establishes lifelong latency in human trigeminal ganglia (tg). currently, two non-exclusive control mechanisms of hsv-1 latency are discussed: anti-viral cd8(+) t cells and viral micro rnas (mirna) encoded by the latency associated transcript (lat). here we investigate to what extent these mechanisms may contribute to the maintenance of hsv-1 latency. in the current study we show, that only a small proportion of lat(+) neurons is surroun ... | 2011 | 21795359 |
| an unusual variant of ramsay hunt syndrome. | | 2011 | 21785398 |
| emerging drugs for varicella-zoster virus infections. | introduction: varicella-zoster virus (vzv) is the etiological agent of two distinct diseases, varicella (chickenpox) and shingles (herpes zoster). chickenpox occurs following primary infection, while herpes zoster (usually associated with ageing and immunosuppression) is the consequence of reactivation of the latent virus. post-herpetic neuralgia is the major complication of shingles. areas covered: this review will discuss vaccination strategies and the current status of antivirals against vzv. ... | 2011 | 21699441 |
| human immunoglobulin g levels of viruses and associated glioma risk. | few consistent etiological factors have been identified for primary brain tumors. inverse associations to asthma and low levels of varicella-zoster virus, immunoglobulin (ig) levels in prevalent cases have indicted a role for the immune system in the development of glioma. because samples from prevalent cases of glioma could be influenced by treatments such as steroids and chemotherapy, we investigated pre-diagnostic samples from three large scandinavian cohorts. to test the hypothesis that immu ... | 2011 | 21717196 |
| novel 1,2,4-triazole and purine acyclic cyclopropane nucleoside analogues: synthesis, antiviral and cytostatic activity evaluations. | several published studies indicate that the acyclic guanine nucleoside analogues possessing bis(1,2-hydroxymethyl) substituted cyclopropane rings mimicking the sugar moiety are potent inhibitors of replication of several herpes viruses. | 2011 | 21730369 |
| Varicella zoster virus (VZV) infects and establishes latency in enteric neurons. | Case reports have linked varicella-zoster virus (VZV) to gastrointestinal disorders, including severe abdominal pain preceding fatal varicella and acute colonic pseudoobstruction (Ogilvie's syndrome). Because we had previously detected DNA and transcripts encoding latency-associated VZV gene products in the human gut, we sought to determine whether latent VZV is present in the human enteric nervous system (ENS) and, if so, to identify the cells in which it is located and its route to the bowel. ... | 2011 | 22190254 |
| Detection of herpes simplex virus (1 and 2), varicella-zoster virus, cytomegalovirus, human herpesvirus 6 and enterovirus in immunocompetent tunisian patients with acute neuromeningeal disorder. | Enteroviruses (EVs) and human herpesviruses (HHVs) are involved frequently in acute neurological disorders of viral etiology. This study aimed to investigate the incidence of herpes simplex virus types-1 (HSV-1) and 2 (HSV-2), varicella-zoster virus (VZV), cytomegalovirus (CMV), human herpesvirus 6 (HHV-6) and human enteroviruses (EVs) in cerebrospinal fluid (CSF) samples of Tunisian immunocompetent patients with neuromeningeal disorders. The patients had been hospitalized at the Fattouma Bourgu ... | 2012 | 22170549 |
| Maxillary osteonecrosis and spontaneous teeth exfoliation following herpes zoster. | BACKGROUND: Reports of osteonecrosis and spontaneous tooth loss following herpes zoster infection of the fifth cranial are extremely rare. Only 39 previously recorded cases of post-zoster osteonecrosis have been found in the literature. The unusual feature of the case of interest to the dental surgeon is a rare complication of tooth exfoliation and maxillary osteonecrosis. CASE REPORT: This article reports a case ... | 2011 | 22069058 |
| Communicable diseases prioritized for surveillance and epidemiological research: results of a standardized prioritization procedure in Germany, 2011. | To establish strategic priorities for the German national public health institute (RKI) and guide the institute's mid-term strategic decisions, we prioritized infectious pathogens in accordance with their importance for national surveillance and epidemiological research. | 2011 | 21991334 |
| a critical role for stat3 transcription factor signaling in the development and maintenance of human t cell memory. | stat3 transcription factor signaling in specific t helper cell differentiation has been well described, although the broader roles for stat3 in lymphocyte memory are less clear. patients with autosomal-dominant hyper-ige syndrome (ad-hies) carry dominant-negative stat3 mutations and are susceptible to a variety of bacterial and fungal infections. we found that ad-hies patients have a cell-intrinsic defect in the number of central memory cd4(+) and cd8(+) t cells compared to healthy controls. nai ... | 2011 | 22118528 |
| genetic factors influence serological measures of common infections. | antibodies against infectious pathogens provide information on past or present exposure to infectious agents. while host genetic factors are known to affect the immune response, the influence of genetic factors on antibody levels to common infectious agents is largely unknown. here we test whether antibody levels for 13 common infections are significantly heritable. | 2011 | 21996708 |
| varicella zoster virus meningoencephalitis accompanied by rhabdomyolysis without skin eruption. | we report a case of a 38-year-old man with a varicella zoster virus (vzv) reactivation who manifested meningoencephalitis accompanied by rhabdomyolysis without a skin eruption. during the acute phase, vzv dna was detected in serum and cerebrospinal fluid (csf) by the polymerase chain reaction (pcr). after 16 days, all symptoms and signs resolved, and follow-up pcr studies revealed negative conversion of vzv in the serum and csf. we discuss the possible underlying mechanism of vzv reactivation in ... | 2011 | 21932091 |
| Epstein-barr virus coinfection in cerebrospinal fluid is associated with increased mortality in malawian adults with bacterial meningitis. | Mortality from adult bacterial meningitis exceeds 50% in sub-Saharan Africa. We postulated that-particularly in individuals infected with human immunodeficiency virus (HIV)-herpes simplex virus, varicella zoster virus, Epstein-Barr virus (EBV), and cytomegalovirus (CMV) in the cerebrospinal fluid (CSF) contribute to poor outcome. CSF from 149 Malawian adults with bacterial meningitis and 39 controls were analyzed using polymerase chain reaction. EBV was detected in 79 of 149 bacterial meningitis ... | 2012 | 22075766 |
| Varicella zoster virus: complications in an ANCA-positive vasculitis. | | 2011 | 21959737 |
| Case report: successful epiradicular peripheral nerve stimulation of the c2 dorsal root ganglion for postherpetic neuralgia. | Postherpetic neuralgia (PHN) is the most common complication following an acute varicella zoster virus infection. PHN often results in a chronic severe pain condition refractory to conservative pain management treatments. Peripheral nerve stimulation over the affected spinal nerve root may be an effective treatment option for patients with intractable PHN. | 2011 | 21992163 |
| guillain-barre syndrome presenting with sensory disturbance following a herpes virus infection: a case report. | abstract: introduction: we present a case of an unusual clinical manifestation of guillain-barre syndrome following a pre-existing herpes virus infection. although there have been several reports describing the co-existence of herpes virus infection and guillain-barre syndrome, we undertook a more in-depth study of the cross-reactivity between herpes viruses and recommend a follow-up study based on serology tests. case presentation: a 39-year-old healthy caucasian man with guillain-barre syndro ... | 2011 | 22136568 |
| host and viral traits predict zoonotic spillover from mammals. | the majority of human emerging infectious diseases are zoonotic, with viruses that originate in wild mammals of particular concern (for example, hiv, ebola and sars). understanding patterns of viral diversity in wildlife and determinants of successful cross-species transmission, or spillover, are therefore key goals for pandemic surveillance programs. however, few analytical tools exist to identify which host species are likely to harbour the next human virus, or which viruses can cross species ... | 2017 | 28636590 |