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failure of doxycycline treatment in aquarium-associated mycobacterium marinum infections.two cases of aquarium-associated mycobacterium marinum infections are described. neither was cured by the initial therapy consisting of surgical excision followed by doxycycline treatment. both strains of m. marinum were shown to be resistant to doxycycline. in one patient the lesions were subsequently healed with cotrimoxazole. the other patient, a 12-year-old girl with sporotrichoid spread of the lesions on the lower arm, failed to respond satisfactorily to a combination of rifampicin and etha ...19873423745
aquarium-borne mycobacterium marinum skin infection. report of a case and review of the literature.a 33-year-old fish fancier developed a protracted skin infection that ultimately was found to be caused by mycobacterium marinum. the organism was isolated from the lesion as well as from infected fish taken from his home aquarium. the lesion resolved after a six-week course of oral sulfamethoxazole and trimethoprim. forty-four additional cases of culture-proved m marinum skin infections acquired from aquariums and reported in the english-language literature are reviewed. almost universally, the ...19863487289
antigen-specific t-cell anergy in progressive mycobacterium marinum infection in humans.the cellular immune responses of 12 patients with culture-proved mycobacterium marinum infection involving deep tissues were studied. of the 12 patients, 11 failed to respond to m. marinum antigens. all of the patients had, however, normal blastogenic responses to concanavalin a, phytohemagglutinin, pokeweed mitogen, and the antigens tetanus toxoid and candida albicans. in contrast, 9 of 14 healthy fishermen responded to the m. marinum antigens with significant in-vitro blastogenesis. infection ...19873499107
amikacin treatment for mycobacterium marinum infection. 19863546444
immunogenic behaviour of mycobacterium marinum (sato) in mice. 19863557568
fish-tank granuloma. the first reported case in south africa.the first case of infection with the non-tuberculous mycobacterium, mycobacterium marinum, in south africa is reported. of special interest was the linear nodular (sporotrichoid) appearance.19873563758
mycobacterium marinum infections. a problem of recognition, not therapy? 19873579434
mycobacterium marinum infections of the hand.fifteen patients had culture proven mycobacterium marinum infections of the hand; 11 had injured their hands while fishing in water around long island. no patient had type i lesions (verrucal), six patients had type ii lesions (subcutaneous granulomas), and nine patients had type iii lesions (deep). histologic examination showed noncaseating granulomas in all cases. a specific defect in the patients' lymphocytes ability to respond to m. marinum antigens was identified. a combination of surgery a ...19873584892
mycobacteriosis in cultured striped bass from california.striped bass (morone saxatilis) juveniles raised in an intensive culture system had chronic mortality resulting from infections with mycobacterium marinum. approximately one-half of a population of 900 yearlings succumbed to the disease and 80% of those remaining were infected. the bacteria were isolated on petrignani's medium after 7 days at 25 c and subcultures grew at temperatures from 20 to 37 c. the disease was characterized by systemic nodular lesions in all major organs. older tubercles c ...19873625895
mycobacterium marinum infection of the hand and wrist. results of conservative treatment in twenty-four cases.inadequate débridement, extensive scarring, and breakdown of the wound have been commonly encountered after surgical débridement has been employed as the initial treatment of infection with mycobacterium marinum involving the deep structures of the hand. because of our disappointment with the results of this form of treatment, from 1982 to 1986 we treated twenty-four patients who had such an infection with rifampicin and ethambutol after a diagnostic biopsy was done. surgical treatment was defer ...19873667646
tetracyclines in therapy of mycobacterium marinum infections. 19873675110
a case of clinically unsuspected mycobacterium marinum infection. 19873689470
an unusually aggressive mycobacterium marinum hand infection.an unusually aggressive mycobacterium marinum infection of the hand that progressed despite surgical and medical treatment is presented. the infection progressed over a 3-week period after the patient had surgical treatment and received isoniazid (inh), rifampin, and ethambutol hydrochloride. the patient had a collar-button abscess, destruction of the metacarpophalangeal (mcp) joint capsule, flexor and extensor tenosynovitis, and metacarpal and proximal phalanx bone destruction at the mcp joint ...19863760509
the histopathologic spectrum in mycobacterium marinum infection.review of nine culture-positive cases of mycobacterium marinum infection revealed a broad range in the histopathologic features of lesions produced by this organism. four synovial lesions and five cutaneous infections were observed. a range of inflammatory changes were seen in both synovial and skin lesions, varying from mostly acute inflammation with suppuration to a more chronic process with numerous, well-formed granulomas. organisms were observed in the biopsy sections of only one of the nin ...19853840985
mycobacterium marinum infections in man. 19853886781
the free lipids of mycobacterium leprae harvested from experimentally infected nine-banded armadillos.the free lipids of a sample of mycobacterium leprae were extracted by a procedure designed to produce separate non-polar and polar fractions. the composition of these lipids was analysed semi-quantitatively by five special thin-layer chromatographic systems covering the total range of mycobacterial lipid polarities. in order of increasing polarity, the major lipids were dimycocerosates of phthiocerol a, phthiocerol b and phthiodiolone a, glycosyl phenolphthiocerol dimycocerosates and phospholipi ...19853903039
therapy of mycobacterium marinum infections. use of tetracyclines vs rifampin.we describe four patients with mycobacterium marinum infections who did not respond to two- to six-week courses of therapy with tetracycline, minocycline, and doxycycline. all four patients had prompt responses to therapy with either rifampin alone (two patients) or rifampin in combination with ethambutol. results of antimicrobial sensitivity tests may be helpful in guiding therapy. rifampin may be the drug of choice for treatment of these infections.19863963983
[swimming pool granuloma--a mycobacteriosis].we report on a patient suffering from swimming pool granuloma after having handled in fresh-water aquarium. as the causative organism, we could isolate mycobacterium marinum from a nodular, ulcerous lesion.19853984425
the histopathology of mycobacterium marinum synovitis.eight patients with culture-proven mycobacterium marinum synovitis had synovial specimens with a remarkably similar histologic appearance. there was considerable synovial hyperplasia, and the synovium was thickened by a moderately intense lymphohistiocytic infiltrate, notably devoid of plasma cells. fibrin covered some synovial surfaces. giant cells were both of the langerhans' and foreign body types. granulomas were noncaseating but varied in frequency and degree of definition. knowledge of thi ...19853984939
mycobacterium marinum infection in a 4-year-old child.infections with mycobacterium marinum are uncommon in children but should be considered by a physician confronted with chronic, poorly healing skin lesions. a case of such an infection in a 4-year-old child is presented. presenting signs and symptoms, differential diagnosis, and treatment of these infections are discussed.19853987170
multiplication of mycobacterium marinum within phagolysosomes of murine macrophages.both in vivo and in vitro, mycobacterium marinum organisms were found to multiply within phagolysosomes of murine macrophages. it thus appears that m. marinum are neither killed nor inhibited from multiplying by lysosomal enzymes.19853997252
importance of the footpad lesion in the mouse response to local inoculation of mycobacterium marinum.the importance of the footpad lesion was studied in cba mice inoculated in the hind footpad with viable or heat-killed mycobacterium marinum popliteal or popliteal and inguinal lymphadenectomy was followed by modest enhancement of the process only when node excision was carried out 6 days after inoculation of a small number of viable organisms. following inoculation in the footpad of a large number of heat-killed organisms, only 10% of the inoculum was recovered from the site of inoculation, onl ...19854004150
[tenosynovitis of the hand due to mycobacterium marinum. apropos of a case].the authors report one case of mycobacterium marinum of the deep structures of the hand and review the literature on the subject. the symptoms are not specific: biopsy and culture are essential for diagnosis. as chemotherapy does not seem to be of help, wide surgical incision is the appropriate treatment.19854026432
unusual cutaneous dissemination of a tropical fish tank granuloma.a patient with an unusual disseminated tropical fish tank granuloma is presented. the infection manifested first as red, subcutaneous nodules of the right hand and forearm. during subsequent days and weeks, nodules appeared on the left arm, on the ventral and dorsal thorax, on one leg, and the face. the diagnosis was based on, in addition to the history and the clinical aspects, a positive reaction to intracutaneous testing with a specific mycobacterium marinum antigen and on the histologic exam ...19854064761
systemic mycobacterium marinum infection in an amazon manatee. 19854077647
differential identification of mycobacterium kansasii and mycobacterium marinum.this report deals with the differential diagnosis between mycobacterium marinum and m. kansasii. we found that the two species could be differentiated by using six main tests, namely, the nitrate reduction test, the arylsulfatase test, the ability to grow in the presence of 10.0 mug of amithiazone per ml, the ability to grow in the presence of 5.0 mug of kanamycin per ml, the temperature-ratio test, and the rate of growth on solid medium. in contrast to m. kansasii, considerable variation was ob ...19714101184
effect of variation in growth temperature on the biochemical activity and antigens of mycobacterium marinum. 19744152345
aquarium-borne infection with mycobacterium marinum. 19704192314
an atypical mandibular tumor caused by mycobacterium balnei. 19734201921
mycobacterial skin tests in humans 12 years after infection with mycobacterium marinum. 19744207272
[verrucous cutaneous tuberculosis cuased by mycobacterium balnei from waters of a coal mine]. 19734268284
[mycobacterium marinum infection mimicking cutaneous leishmaniasis]. 19744435649
[mycobacterium marinum infection of the skin]. 19724539230
temperature-dependent infection of mycobacterium marinum (balnei) in the chick embryo. 19734542323
[isolation of atypical acid-fast mycobacterium marinum and sporotrichum in a case of granuloma]. 19734542441
differentiation between mycobacterium kansasii and mycobacterium marinum. 19734566852
analogy of mycobacterium marinum disease to mycobacterium leprae infection in footpads of mice.because it appeared likely that the disease process that follows inoculation of footpads of mice with mycobacterium marinum might serve as a useful model of mouse footpad infection with m. leprae for immunological studies. an attempt was made to establish an analogy between the two processes. as a second objective, the adequacy of measurements of mouse footpad thickness as an index of the total number of m. marinum and of the number of viable m. marinum was determined. the evolution of m. marinu ...19734594116
[a case of mycobacterium marinum infection of bucca--with special reference to the bacteriological investigations]. 19724643909
differentiation between mycobacterium kansasii and mycobacterium marinum by gas-liquid chromatographic analysis of cellular fatty acids.comparison of the cellular fatty acids of 10 strains of mycobacterium marinum and 35 strains of mycobacterium kansasii revealed similarities within each species but differences between these two photochromogenic mycobacteria. a branched-chain fatty acid characteristic of m. kansasii was found in trace amounts in 2 of the 10 strains of m. marinum.19724650594
[pathogenic bacteria common to man and fish--mycobacterium marinum isolated from skin granuloma in man]. 19724677312
mycobacterium marinum infections of the hand. report of three cases and review of the literature. 19734696166
mycobacterium marinum in gulf fishermen. 19734709116
[mycobacterium balnei in the water of mines as a causal agent of the verrucous tuberculosis of the skin. (case report)]. 19734709185
mycobacterium marinum (atypical acid-fast bacillus) infections of the hand. 19734760089
opportunistic cutaneous mycobacterium marinum infection mimicking mycobacterium ulcerans in lymphosarcoma. 19734800424
sporotrichoid mycobacterium marinum infection in a child. 19734802594
sporotrichoid infection due to mycobacterium marinum: lesion exacerbated by corticosteroid infiltration. 19744808977
[chronic infection due to mycobacterium marinum from an aquarium]. 19744814528
letter: mycobacterium marinum infection. 19744819118
differential identification of mycobacterium kansasii and mycobacterium marinum. 19714925535
differentiation of the two photochromogenic mycobacterial species: mycobacterium kansasii hauduroy and mycobacterium marinum aronson by means of the diamine-oxydase test. 19674964971
systemic chemotherapy in mice experimentally infected with mycobacterium marinum. 19715004745
sporotrichoid mycobacterium marinum infection treated with rifampin-ethambutol. 19725032717
mycobacterium marinum granuloma. a disease acquired in the tributaries of chesapeake bay. 19725039106
skin infection with mycobacterium marinum from a tropical fish tank. 19715103909
a study of the relationship of structure and activity of antimycin a in the induction of carotenoid synthesis in mycobacterium marinum. 19715129724
mycobacterium marinum infections acquired from tropical fish tanks. 19715146929
paratuberculosis cutis caused by mycobacterium marinum. 19715165484
relation of infection to tissue temperature in mice infected with mycobacterium marinum and mycobacterium leprae.intravenous and footpad infections with mycobacterium marinum and footpad infections with m. leprae were compared in the following mouse strains: a/he, balb/c, cba, c3h, c57bl, c57l, dba, 101, and cfw. the results varied a great deal according to mouse strain used. intravenous injection of high doses of m. marinum resulted in deaths after 28 days of 100% of strain a/he, and none of strain 101; 27 days after injection, the feet and noses of all strain cba mice, but few of the c57bl, 101, or cfw m ...19675337835
epidemiological analysis in a patient with skin granuloma caused by mycobacterium balnei. 19705426300
[epidemiological study in reference to a patient with skin infection caused by mycobacterium balnei]. 19705445138
[case of unusual multiple skin diseases due to mycobacterium marinum]. 19705462340
tropical fish aquariums. a source of mycobacterium marinum infections resembling sporotrichosis. 19705466918
human infection due to mycobacterium marinum after a dolphin bite.a young man employed at the local aquarium was bitten by a bottlenose dolphin (tursiops truncatus) during a training session, receiving a slight injury which healed rapidly. some two months later fluctuant swellings appeared in the region of the bite, which developed into indolent ulcers which have not completely healed seven months after the original bite. cultures taken on two occasions have yielded a pure growth of mycobacterium marinum.19705529254
[tuberculosis resembling skin disease caused by mycobacterium marinum (so-called swimming pool granuloma)]. 19675590972
mycobacterium marinum (balnei) infection. report of a case with cutaneous and laryngeal lesions. 19685636049
mechanism of photoinduced and antimycin a-induced carotenoid synthesis in mycobacterium marinum. effect of proflavine. 19685701191
mechanism of photo-induced and antimycin a-induced carotenoid synthesis in mycobacterium marinum. requirements for carotenogen- esis and further evidence for protein synthesis following induction. 19695781184
thin-layer chromatography of mycobacterial lipids as an aid to classification; mycobacterium kansasii; and mycobacterium marinum (balnei). 19665936896
factors affecting the growth of mycobacterium marinum. 19665969334
[classification and identification of slow-growing mycobacteria. (3). mycobacterium marinum]. 19666009582
[on the bacteriological diagnosis of tuberculoid skin disease due to mycobacterium marinum]. 19676068915
induction of carotenoid synthesis by antimycin a in the dark in mycobacterium marinum. 19676077048
fish tank granuloma.a case of fish tank granuloma is presented. a lesional biopsy sample yielded growth of mycobacterium marinum on löwenstein's medium. treatment with cotrimoxazole was successful.19806162325
specificity and distribution of alpha antigens of mycobacterium kansasii and mycobacterium marinum.specificity of antigenic determinants in alpha antigens of mycobacterium kansasii and mycobacterium marinum was investigated in 170 strains classified into 16 species of slowly growing mycobacteria by the agar gel diffusion technique using the respective absorbed anti-alpha serum. the specific antigenic determinants in alpha antigen of m. kansasii were detected in all of the 20 strains classified as m. kansasii, and not in strains belonging to other species. the specific antigenic determinants i ...19846207754
effects of treatment with muramyl dipeptide on resistance to mycobacterium leprae and mycobacterium marinum infection in mice.studies were carried out to determine whether treatment of mice with the synthetic adjuvant muramyl dipeptide (mdp) afforded resistance to infection with mycobacterium leprae or m. marinum in mice. regardless of the timing, dose, or route of administration, there was no evidence that treatment with mdp or 3 of its analogs (desmdp, abumdp, valmdp) enhanced resistance to food pad infection with m. leprae or m. marinum. in parallel studies, systemic treatment with propionibacterium acnes failed to ...19836343295
cutaneous infections: microbiologic and epidemiologic considerations.the normal bacterial flora of the skin represents an important host defense mechanism against invasion by potentially pathogenic organisms. this flora is primarily composed of aerobic diphtheroids (corynebacterium species), anaerobic diphtheroids (propriono-bacterium acnes), and coagulase-negative staphylococci. gram-negative bacilli may be present in limited numbers in intertriginous areas. localized cutaneous infections occur in ostensibly normal hosts, often after trivial trauma, examples bei ...19846372467
mycobacterium marinum infection of the skin in japan. 19846376574
experimental mycobacterial infections of cba/n mice.in an effort to assess the contribution of b-lymphocyte-mediated mechanisms to the immune responses to several mycobacteria, responses to these intracellular pathogens were compared in immunologically normal cba/cahn mice and in histocompatible cba/n (xid) mice, which exhibit abnormalities of b-lymphocyte function. swelling in response to local inoculation with mycobacterium marinum was significantly greater in the hind feet of cba/cahn mice than in those of cba/n mice, but the difference was ve ...19846381393
[change in cell-mediated immunity to mycobacterium leprae and mycobacterium marinum in hansen's disease patients].the cell mediated immunity (cmi) to protein purified derivates of mycobacterium leprae, mycobacterium tuberculosis, mycobacterium avium and mycobacterium marinum was studied. leukocyte migration inhibition (lmi) and delayed hypersensitivity skin reactions to these antigens were examined in 44 hanseniasis patients (20 quiescent virchowians, 13 reactional virchowians and 11 tuberculoid patients) and 15 healthy subjects. an impairment in lmi and delayed hypersensitivity tests to m. leprae and m. ma ...19836432692
benzylamines: synthesis and evaluation of antimycobacterial properties.the synthesis of benzylamines with various n-alkyl chains and substituents in the aromatic system as well as their evaluation on mycobacterium tuberculosis h 37 ra are described. the most active compounds in this test, n-methyl-3-chlorobenzylamine (19, mic 10.2 micrograms/ml), n-methyl-3,5-dichlorobenzylamine (93, mic 10.2 micrograms/ml), and n-butyl-3,5-difluorobenzylamine (103, mic 6.4 micrograms/ml), also exhibited a marked inhibitory effect on mycobacterium marinum and mycobacterium lufu use ...19846433022
[swimming pool granuloma--an atypical mycobacterial infection].after an introduction on the problem of swimming pool or fish tank granulomas--chronic granulomatous skin infections with mycobacterium marinum--we present two of our own cases. the disease is discussed and the signs and symptoms, histological changes, and therapeutic methodology presented.19846469642
response of the popliteal lymph node to reinfection of the hind foot pad of the mouse with mycobacterium marinum.in c57bl mice inoculated with mycobacterium marinum in the right hind foot pad 2 weeks earlier ("previously infected mice"), inoculation of m. marinum into the left hind foot pad was followed by accelerated enlargement of the left popliteal node. popliteal-node lymphocytes harvested from previously infected donors, labeled with 3h-uridine in vitro, and infused intravenously into previously infected recipients at the time of reinfection in the left hind foot pad homed on the left popliteal node. ...19846481791
sporotrichoid mycobacterium marinum infection. report of a ten-year case. 19846500798
mycolic acid patterns of some species of mycobacterium.representative strains of some species of mycobacterium were degraded by both acid and alkaline methanolysis. two-dimensional thin-layer chromatography was used to determine the patterns of mycolic acids and other long-chain components in these methanolysates. patterns composed of alpha-, methoxy- and ketomycolates were found in mycobacterium asiaticum, mycobacterium bovis, mycobacterium gastri, mycobacterium gordonae, mycobacterium kansasii, mycobacterium marinum and mycobacterium tuberculosis; ...19846517656
[in vitro susceptibility of mycobacterium marinum to amikacin sulfate]. 19836620633
mycobacterium marinum infection of the hand involving deep structures.five patients with mycobacterium marinum infection of the hand involving deep structures were seen recently. four of them were fishermen. hydrocortisone injection or simple incision and drainage led to worsening of the infection. the clinical presentation, operative finding, and histopathologic and microbiologic features were quite similar in all five patients. extensive debridement and therapy with ethambutol and rifampin led to satisfactory results in four patients while biopsy and therapy in ...19836630930
systemic mycobacterium marinum infection in a european hedgehog. 19836643246
agar disk elution method for susceptibility testing of mycobacterium marinum and mycobacterium fortuitum complex to sulfonamides and antibiotics.an agar disk elution method using round well plates, supplemented mueller-hinton agar, and commercial drug disks is described for susceptibility testing of mycobacterium marinum and the rapidly growing mycobacteria to antibiotics and sulfonamides. by this method, 14 of 14 strains of m. marinum were susceptible to rifampin, doxycycline, minocycline, and trimethoprim-sulfamethoxazole. identical results were obtained with middlebrook 7h10 agar and drugs prepared from standard powders. with 58 isola ...19836651277
[infection with mycobacterium marinum from an aquarium].clinical, histological and electron microscopical findings of swimming pool granuloma in a 19-year-old soldier are demonstrated. isolation of mycobacterium marinum and positive tests with the "marinum sensitin" confirmed diagnosis. problems of treatment are discussed.19836662729
[in vitro susceptibility of mycobacterium marinum to st preparation (sulfamethoxazole-trimethoprim)]. 19836663794
fish fancier's finger.infection of the flexor tendon sheath and proximal interphalangeal joint by mycobacterium marinum is described. the characteristic features of this unusual infection are delineated.19846737381
[apropos of the 2nd case of cutaneous granuloma caused by mycobacterium marinum in uruguay].a new, second uruguayan case of cutaneous granuloma by mycobacterium marinum is presented. the patient a 31 years old white man from montevideo city had two granulomatous and ulcerated lesions on the right knee, secondary to wounds suffered with mussels' shells 5 years before while cleaning his boat in saline waters close to our rio de la plata river. diagnosis was made by finding the typical acid fast organisms in the lesions, the isolation of the agent in cultures and through experimental inoc ...19826764231
disseminated cutaneous mycobacterium marinum infection. 19836824363
mycobacterium marinum tenosynovitis in a long island fisherman. 19816942253
[minocycline hydrochloride treatment for mycobacterium marinum infection of the skin. (author's transl)]. 19806966697
disseminated mycobacterium marinum infection after renal transplantation. 19817011140
the effect of body temperature and cell-mediated immunity on the growth of mycobacterium marinum and mycobacterium leprae in mice.evidence is presented that the high susceptibility of armadillos to infection with mycobacterium leprae cannot be explained solely in terms of body temperature because mutant mice maintained with a body temperature similar to that of armadillos do not become heavily infected with m. leprae. the depression of cell-mediated immunity accompanying the low body temperature is not sufficient to produce an overwhelming infection. the results obtained with m. marinum suggest that whereas lack of cell-me ...19817031255
mycobacterium marinum infection. a fishy story. 19827062549
in vitro activity of trimethoprim and sulfamethoxazole against the nontuberculous mycobacteria.trimethoprim (tmp) and sulfamethoxazole (smz) were studied alone and in combination (tmp-smz) against 141 nontuberculous mycobacteria; an agar dilution method was used. all strains of mycobacterium kansasii (8), mycobacterium marinum (16), and mycobacterium scrofulaceum (3); 97% (63 of 65) of strains of mycobacterium fortuitum; and 27% (3 of 11) of strains of mycobacterium avium-intracellulare were inhibited by less than or equal to 32 micrograms of smz/ml. in contrast, all 38 isolates of mycoba ...19827111959
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