Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| Pilot study: individualized training for caregivers of hospitalized older veterans. | : The hospital-to-home transition represents a vulnerable time for older veterans who are more medically and socioeconomically challenged than the general population of older adults. | 2011 | 22067595 |
| Evaluation of hybrid treatments to produce high quality reuse water. | Four tertiary hybrid treatments to produce high quality reused water, fulfilling Brazilian drinking water regulations, from a slaughterhouse's secondary treated effluent were evaluated. The pilot plant with a capacity of 500 L h(-1) was set up and consisted of these stages: pre-filtration system (cartridge filter 50 micron, activated carbon filter, cartridge filter 10 micron), oxidation (H2O2) or second filtration (ceramic filter, UF) followed by UV radiation (90 L h(-1)). The best combination w ... | 2011 | 21902048 |
| the outcome of laparoscopic colorectal resection in t4 cancer. | aim:ôçé laparoscopic surgery for locally advanced tumours with extramural involvement is still controversial. it is believed that laparoscopic excision of t4 cancers is technically difficult and may result in prolonged operative time, increased conversion rate, added post-operative morbidity, and suboptimal oncological clearance. method:ôçé our unit has been practising laparoscopic colorectal surgery since 1992, and all data are entered into a database prospectively. since 1999 we have routinely ... | 2011 | 21689365 |
| thyroid function during critical illness. | the metabolic support of the critically ill patient is a relatively new target of active research and little is as yet known about the effects of critical illness on metabolism. the nonthyroidal illness syndrome, also known as the low t3 syndrome or euthyroid sick syndrome, describes a condition characterized by abnormal thyroid function tests encountered in patients with acute or chronic systemic illnesses. the laboratory parameters of this syndrome include low serum levels of triiodothyronine ... | 2011 | 21724536 |
| evaluation of effect of isoflavone on thyroid economy & autoimmunity in oophorectomised women: a randomised, double-blind, placebo-controlled trial. | the potential of soy isoflavones to interfere with thyroid function has been reported. however, there are limited data regarding their effect on thyroid function and autoimmunity in surgical menopausal women. the present study aimed to evaluate the effect of isoflavones on thyroid function and autoimmunity, menopausal symptoms, serum follicle stimulating hormone (fsh) and estradiol levels in oophorectomised women. | 2011 | 21727662 |
| predictive factors for pulmonary metastases after curative resection of rectal cancer without preoperative chemoradiotherapy. | the aim of this study was to clarify the actuarial incidence of pulmonary metastases and risk factors for pulmonary metastases after curative resection of rectal cancer without preoperative chemoradiotherapy. | 2011 | 21730788 |
| Disaster metrics: quantitative benchmarking of hospital surge capacity in trauma-related multiple casualty events. | Objectives:-á Hospital surge capacity in multiple casualty events (MCE) is the core of hospital medical response, and an integral part of the total medical capacity of the community affected. To date, however, there has been no consensus regarding the definition or quantification of hospital surge capacity. The first objective of this study was to quantitatively benchmark the various components of hospital surge capacity pertaining to the care of critically and moderately injured patients in tra ... | 2011 | 21685307 |
| Extent of lung resection in non-small lung cancer with interlobar lymph node involvement. | Optimal resection type for non-small cell lung cancer (NSCLC) with interlobar lymph node involvement (ILNI) has seldom been reported. To completely resect a NSCLC with ILNI, some surgeons believe that a pneumonectomy is needed. | 2011 | 21697782 |
| Insights into molecular properties of the human monocarboxylate transporter 8 by combining functional with structural information. | The monocarboxylate transporter 8 (MCT8) is a member of the major facilitator superfamily (MFS) and transports specificly iodothyronines. MCT8 mutations are the underlying cause of a syndrome of severe X-linked psychomotor retardation known as the Allan-Herndon-Dudley syndrome. This syndrome is characterized by abnormally high T3, low/normal T4 serum levels and slightly elevated serum TSH. To date, more than 25 pathogenic mutations in hMCT8 are known and they are valuable indicators of important ... | 2011 | 21835051 |
| Circumferential Resection Margin Involvement after Laparoscopic Abdominoperineal Resection for Rectal Cancer. | Aim:ÔÇé This study aimed to evaluate circumferential resection margin (CRM) involvement in patients with rectal adenocarcinoma after laparoscopic abdominoperineal resection (APR). Method:ÔÇé Prospectively collected data were analyzed on consecutive patients who underwent laparoscopic APR for histologically-proven rectal cancer following neoadjuvant chemotherapy from 1998 to 2006. Patients with no sphincter involvement were not included and underwent intersphincteric resection with coloanal anast ... | 2011 | 21689315 |
| the pharmacists' role in improving guideline compliance for thyroid function testing in patients with heart failure. | this single-center retrospective pilot program's objective was to utilize outpatient pharmacists to improve laboratory test adherence in chronic heart failure (chf) patients overdue for thyroid function testing, thereby demonstrating the value of the outpatient pharmacist and justifying possible clinical role expansion. thyroid disorders may contribute to chf development, progression, and exacerbation. testing is the standard of care in chf patients per american heart association's 2009 guidelin ... | 2011 | 21844214 |
| the follow up of radioiodine treated hyperthyroid patients: should thyroid function be monitored more frequently? | background: there is a lack of data regarding the timing and particularly the severity of hypothyroidism post radioiodine (ri). aim: to investigate the timing and severity of hypothyroidism in ri treated hyperthyroid patients. methods: retrospective examination of the records of 183 ri treated hyperthyroid patients (79 patients autoimmune hyperthyroidism, 46 toxic mng and 58 hyperthyroidism of indeterminate aetiology). results: 159 patients requiring a single dose of ri (435 mbq), 107 (67%) deve ... | 2011 | 21720207 |
| metastatic potential in renal cell carcinomas ôëñ7cm: swedish kidney cancer quality register data. | background: renal cell carcinoma (rcc) represents 2-3% of all malignancies and accounts for approximately 90% of all kidney malignancies. an increasing proportion of rccs are discovered incidentally, and the average tumor diameter at diagnosis has decreased over the last few decades. small rccs have often been regarded by many as relatively harmless. objective: the objective was to evaluate the incidence of local t-category distribution and lymph node and distant metastases in relation to tumor ... | 2011 | 21741160 |
| levothyroxine monotherapy cannot guarantee euthyroidism in all athyreotic patients. | levothyroxine monotherapy is the treatment of choice for hypothyroid patients because peripheral t4 to t3 conversion is believed to account for the overall tissue requirement for thyroid hormones. however, there are indirect evidences that this may not be the case in all patients. | 2011 | 21829633 |
| type 2 deiodinase at the crossroads of thyroid hormone action. | thyroid hormone action can be customized on a cell-specific fashion through the controlled action of the deiodinase group of enzymes, which are homodimeric thioredoxin fold containing selenoproteins. whereas the type ii deiodinase (d2) initiates thyroid hormone signaling by activating the pro-hormone thyroxine (t4) to the biologically active t3 molecule, the type iii deiodinase (d3) terminates thyroid hormone action by catalyzing the inactivation of both t4 and t3 molecules. deiodinases play a r ... | 2011 | 21679772 |
| [vertical trapezius myocutaneous flap for repairing soft tissue defect after head and neck tumor resection]. | to introduce the experience of the clinical application of vertical trapezius myocutaneous flap in repairing soft tissue defects after head and neck tumor resection. | 2011 | 21675112 |
| exploring the roles of nucleobase desolvation and shape complementarity during the misreplication of o(6)-methylguanine. | o(6)-methylguanine (o(6)-meg) is a miscoding dna lesion arising from the alkylation of guanine. this report uses the bacteriophage t4 dna polymerase as a model to probe the roles of hydrogen-bonding interactions, shape/size, and nucleobase desolvation during the replication of this miscoding lesion. this was accomplished by using transient kinetic techniques to monitor the kinetic parameters for incorporating and extending natural and nonnatural nucleotides. in general, the efficiency of nucleot ... | 2011 | 21819995 |
| associations between polybrominated diphenyl ether (pbde) flame retardants, phenolic metabolites, and thyroid hormones during pregnancy. | background: polybrominated diphenyl ethers (pbdes) are chemical additives used as flame retardants in commercial products. pbdes are bioaccumulative, persistent, and have been linked to several adverse health outcomes. objectives: this study leverages an ongoing pregnancy cohort to measure pbdes, and pbde metabolites, in serum collected from an understudied population of pregnant women late in their third trimester. a secondary objective was to determine if the pbdes, or their metabolites, were ... | 2011 | 21715241 |
| staged approach prevents spinal cord injury in hybrid surgical-endovascular thoracoabdominal aortic aneurysm repair: an experimental model. | in a porcine model, we investigated the impact of sudden stent graft occlusion of thoracic intercostal arteries after open lumbar segmental artery (sa) ligation. | 2011 | 21718839 |
| sustained control of graves' hyperthyroidism during long-term low-dose antithyroid drug therapy of patients with severe graves' orbitopathy. | background: patients with severe graves' orbitopathy often have hyperthyroidism that is difficult to treat and a high proportion of patients experience relapse of hyperthyroidism after a course of antithyroid drug (atd) therapy of fixed duration. the aim of the study was to evaluate the feasibility of prolonged low-dose atd therapy for attaining stable euthyroidism in patients with severe graves' orbitopathy and hyperthyroidism. methods: we performed retrospective analyses of data collected duri ... | 2011 | 21834677 |
| accelerated radiotherapy and concomitant high dose chemotherapy in non resectable stage iv locally advanced hnscc: results of a gortec randomized trial. | the objective was to evaluate the efficacy of a strong increase of the dose-intensity of concomitant radio-chemotherapy (rt-ct) in patients with far advanced non metastatic hnscc. | 2011 | 21831465 |
| neoadjuvant gemcitabine and cisplatin chemotherapy for locally advanced urothelial cancer of the bladder. | background: the purpose of this study was to investigate the effect of neoadjuvant chemotherapy with gemcitabine and cisplatin (gc) on pathologic down-staging of patients with locally advanced urothelial cancer (uc) of the bladder. methods: this was a retrospective cohort study of patients treated with radical cystectomy (rc) for clinical stage ct2-t4, n any, m0 bladder uc at strong memorial hospital from 1999 to 2009. the primary exposure variable was use of neoadjuvant chemotherapy (gc vs none ... | 2011 | 21720989 |
| apical-node metastasis in sigmoid colon or rectal cancer: is it a factor that indicates a poor prognosis after high ligation? | purpose: the prognostic significance of apical-node metastasis around the inferior mesenteric artery (ima) remains unclear. we investigated the oncological relevance of apical-node metastasis detected after high ligation of the ima in stage iii sigmoid colon or rectal cancer. methods: between may 2003 and december 2007, 229 consecutive patients with stage iii sigmoid colon or rectal cancer, who had undergone curative resection with high ligation, were analyzed. cox proportional regression model ... | 2011 | 21739197 |
| disseminated tumor cells predict survival after neoadjuvant therapy in primary breast cancer. | background: tumor cells that disseminate to the bone marrow (disseminated tumor cells [dtcs]) have been identified in 30% of patients with stage i through ii breast cancer (bc) and predict outcome. neoadjuvant chemotherapy (nact) is effective in reducing the size of primary tumors or eradicating lymph node metastases before surgery, but little is known regarding the presence or significance of dtcs after nact. methods: the authors evaluated dtcs in 95 patients with clinical stage i through iii b ... | 2011 | 21717428 |
| responses of growing japanese quails that received selenium from selenium enriched kale sprout (brassica oleracea var. alboglabra l.). | the objectives of this study were to determine the effect of selenium (se) from se-enriched kale sprout (brassica oleracea var. alboglabra l.) on the performance and se concentrations in tissues of growing japanese quails. two hundred quails were divided into five treatments. each treatment consisted of four replicates and each replicate contained ten quails in a completely randomize design. the experiment was conducted for 5-áweeks. the treatments were t1, control diet; t2, control diet plus 0. ... | 2011 | 21681467 |
| impact of severity, duration, and etiology of hyperthyroidism on bone turnover markers and bone mineral density in men. | abstract: background: hyperthyroidism is accompanied by osteoporosis with higher incidence of fracture rates. the present work aimed to study bone status in hyperthyroidism and to elucidate the impact of severity, duration, and etiology of hyperthyroidism on biochemical markers of bone turnover and bone mineral density (bmd). methods: fifty-two male patients with hyperthyroidism, 31 with graves' disease (gd) and 21 with toxic multinodular goiter (tng), with an age ranging from 23 to 65 years wer ... | 2011 | 21819612 |
| thyroid hormone transport in developing brain. | to discuss the recent advances on thyroid hormone transport in the brain. a special attention is paid to the x-linked thyroid hormone cell transport (thct) defect (also known as the allan-herndon-dudley syndrome), caused by mutations of the specific thyroid hormone transporter mct8 gene. | 2011 | 21825978 |
| lateral spine radiographs before androgen deprivation treatment detect a high incidence of undiagnosed vertebral fragility fractures in men with advanced prostate cancer. | baseline bone mineral density scanning in patients about to commence long-term androgen deprivation therapy for advanced/metastatic prostate cancer is reported to show a high incidence of osteoporosis and osteopenia. we investigated the incidence of existing spinal osteoporotic fractures in this population as this is known to be a risk factor for the development of treatment induced fractures. | 2011 | 21705031 |
| tranilast prevents the progression of chronic cyclosporine nephrotoxicity through regulation of transforming growth factor +¦/smad pathways. | our aim was to investigate the role of tranilast in transforming growth factor (tgf) +¦/smad pathways using a rat model of chronic cyclosporine (csa) nephrotoxicity. | 2011 | 21693312 |
| altered levels of the onco-microrna 21 and the tumor-supressor micrornas 143 and 145 in advanced rectal cancer indicate successful neoadjuvant chemoradiotherapy. | micrornas (mirnas) are small non-coding rnas with important post-transcriptional regulatory functions. mirna-21 (mir-21) is upregulated and mir-143 and mir-145 are downregulated in colorectal carcinoma. the aim of our study was to determine if these mirnas change their expression levels in response to neoadjuvant chemoradiotherapy in advanced rectal cancer. forty patients with advanced rectal cancer (clinical ut3/t4 nx) were included. all patients underwent neoadjuvant chemoradiotherapy and surg ... | 2011 | 21567082 |
| [therapy of thoracolumbar vertebra tumor by total spondylectomy and spine reconstruction through posterior approach]. | to explore the surgical procedure and effectiveness of total spondylectomy and spine reconstruction through posterior approach to treat thoracolumbar vertebra tumor. | 2011 | 21675110 |
| differential bacteriophage mortality on exposure to copper. | many studies report that copper can be used to control microbial growth, including that of viruses. we determined the rates of copper-mediated inactivation for a wide range of bacteriophages. we used two methods to test the effect of copper on bacteriophage survival. one method involved placing small volumes of bacteriophage lysate on copper and stainless steel coupons. following exposure, metal coupons were rinsed with lysogeny broth and the resulting fluid was serially diluted and plated on ag ... | 2011 | 21841029 |
| combination of differentiation and t stage can predict unresponsiveness to neoadjuvant therapy for rectal cancer. | aimôçé the study aimed to identify the factors predictive for extreme unresponsiveness to neoadjuvant therapy for rectal cancer. methodôçé ninety-six patients with rectal cancer received neoadjuvant therapy before surgery (41 radiotherapy; 55 chemoradiotherapy). tumour response, down staging, pathological complete response (pcr) and disease-free survival were evaluated. resultsôçé tumour response, down-staging and pcr occurred in 70 (72.9%), 47 (49.0%) and 14 (14.6%) patients. univariate analyse ... | 2011 | 21689282 |
| natural course of insomnia comorbid with cancer: an 18-month longitudinal study. | purpose this study aimed to assess the prevalence and natural course (incidence, persistence, remission, and relapse) of insomnia comorbid with cancer during an 18-month period. patients and methods all patients scheduled to receive a curative surgery for a first diagnosis of nonmetastatic cancer were approached on the day of their preoperative visit to participate in the study. a total of 962 patients with cancer (mixed sites) completed an insomnia diagnostic interview at the perioperative phas ... | 2011 | 21825267 |
| recombinant marker allergens in diagnosis of patients with allergic rhinoconjunctivitis to tree and grass pollens. | the aim of this study was to investigate recombinant marker allergens in patients with allergic rhinoconjunctivitis to tree and grass pollens. | 2011 | 21711974 |
| two new ternary complexes of copper(ii) with tetracycline or doxycycline and 1,10-phenanthroline and their potential as antitumoral: cytotoxicity and dna cleavage. | this paper reports on the synthesis and characterization of two new ternary copper(ii) complexes: [cu(doxycycline)(1,10-phenanthroline)(h(2)o)(clo(4))](clo(4)) (1) and [cu(tetracycline)(1,10-phenanthroline)(h(2)o)(clo(4))](clo(4)) (2). these compounds exhibit a distorted tetragonal geometry around copper, which is coordinated to two bidentate ligands, 1,10-phenanthroline and tetracycline or doxycyline, a water molecule, and a perchlorate ion weakly bonded in the axial positions. in both compound ... | 2011 | 21692452 |
| comparison of clinical and pathologic findings of prostate cancers detected through screening versus conventional referral in brazil. | introduction: data regarding prostate cancer screening in brazil are limited. we compared features of prostate cancers detected through screening versus those referred for treatment in brazil. patients and methods: group i included 500 of 13,754 men whose cancers were detected through screening, and group ii included 2731 men referred for treatment through the habitual public health system. we used mann-whitney and ¤ç(2) tests to compare clinical and pathologic findings, considering significant ... | 2011 | 21843976 |
| microrna signature analysis in colorectal cancer: identification of expression profiles in stage ii tumors associated with aggressive disease. | purpose: colorectal cancer (crc) is a clinically diverse disease whose molecular etiology remains poorly understood. the purpose of this study was to identify mirna expression patterns predictive of crc tumor status and to investigate associations between microrna (mirna) expression and clinicopathological parameters. methods: expression profiling of 380 mirnas was performed on 20 paired stage ii tumor and normal tissues. artificial neural network (ann) analysis was applied to identify mirnas pr ... | 2011 | 21739196 |
| thyroid disease in older people. | several changes in thyroid hormone secretion, metabolism, and action occur with the increase in age. aging is often associated with a decrease in serum thyroid stimulating hormone and t3 levels, whereas serum free t4 levels usually remain unchanged. the prevalence of thyroid dysfunction is higher in the elderly as compared to the younger population. in elderly individuals the non-specific clinical manifestations of thyroid hormone excess or deprivation can cause confusion in the clinical setup; ... | 2011 | 21719219 |
| effect of substituting live feed with formulated feed on the reproductive performance and fry survival of siamese fighting fish, betta splendens (regan, 1910). | this study aimed to elucidate the effect of partial or complete replacement of live feed (lf) (tubifex) with formulated feed (ff) on the reproductive performance of betta splendens. three hundred b. splendens fry (average weight 0.19-á-¦-á0.01-ág) were equally distributed into five different groups, each with three replicates. they were fed for 105-ádays with following different diets: control (c)-100% lf; t1-75% lf, 25% ff; t2-50% lf, 50% ff; t3-25% lf, 75% ff, and t4-100% ff. results showed th ... | 2011 | 21710171 |
| flurbiprofen axetil enhances analgesic effect of fentanyl associated with increase in +¦-endorphin levels. | purpose: to examine the analgesic effect of preoperative administration of flurbiprofen axetil and that of postoperative administration of a combination of flurbiprofen axetil and fentanyl, as well as perioperative plasma +¦-endorphin (+¦-ep) levels in patients undergoing esophagectomy. methods: forty-five patients were randomly divided into three groups: group a: 100-ámg flurbiprofen axetil preoperative, 10-á++g/kg fentanyl-á+-á10-áml placebo postoperative; group b: 100-ámg flurbiprofen axetil ... | 2011 | 21725634 |
| the effect of trauma on stress reactivity in aggressive youth. | to address gaps in the literature related to the contribution of childhood trauma on aggression we evaluated salivary cortisol and heart rate changes to psychological challenge in aggressive children with various degrees of trauma. we hypothesized that traumatized and aggressive youths will exhibit higher responsiveness to an active challenge (violent film-vf) than aggressive youth with no trauma but will not differ when viewing a non-violent film (nvf). a total of 25 children (aged 9-12; m=15, ... | 2011 | 21684014 |
| seom clinical guidelines for the treatment of invasive bladder cancer. | the purpose of this article is to provide updated recommendations for the diagnosis and treatment of muscle- invasive and metastatic bladder cancer. the diagnosis of muscle-invasive bladder cancer is made by transurethral resection and following histopathologic evaluation. invasive bladder cancer should be staged according to the uicc system. patients with confirmed muscle-invasive bladder cancer should be staged by computed tomography scans of the chest, abdomen and pelvis. radical cystectomy i ... | 2011 | 21821489 |
| morphologic evaluation of the thoracic vertebrae for safe free-hand pedicle screw placement in adolescent idiopathic scoliosis: a ct-based anatomical study. | objective: to evaluate the morphologic characteristics of the thoracic pedicle with regard to safe free-hand thoracic pedicle screw placement, based on multi-planar reconstruction ct images. methods: thirty adolescent idiopathic scoliosis (ais) patients who had undergone posterior corrective surgery for major thoracic curve were included in this study. reconstructed ct axial images at each thoracic vertebra were used to measure: (1) the shortest distance from an entry point to the ventral cortex ... | 2011 | 21739245 |
| zoster myelitis in sickle cell anemia. | a 17-year-old female patient, known case of sickle cell anemia was admitted to our hospital with 10 days history of fever, vomiting, and epigastric pain. on examination, her temperature was 38-¦c. there was a vesicular type of rash below the nipple and over the left chest involving the back. she was diagnosed as herpes zoster and was started on acyclovir with good hydration and analgesia. three days later, she developed weakness and decreased sensation of the right leg. on the fifth day, examina ... | 2011 | 21677622 |
| [clinical significance of radical cystectomy with extended lymphadenectomy]. | to evaluate the prognosis of patients treated with radical cystectomy and extended lymphadenectomy for invasive bladder cancer and to describe the association of the primary bladder tumor grade, stage, lymph node status and lymph node density with clinical outcomes. | 2011 | 21844970 |
| thyroid hormone regulation by stress and behavioral differences in adult male rats. | thyroid hormones are essential regulators of growth, development and normal bodily function and their release is coordinated by the hypothalamic-pituitary-thyroid (hpt) axis. while the hpt axis has been established as an acutely stress-responsive neuroendocrine system, relatively little is known about the mechanisms of its stress regulation. the present study examined acute stress-induced changes in peripheral hormone levels [triiodothyronine (t3); thyroxine (t4), thyroid-stimulating hormone (ts ... | 2011 | 21689656 |
| mental adjustment to cancer and its relation to anxiety, depression, hrql and survival in patients with laryngeal cancer - a longitudinal study. | using a longitudinal design, aim of this study was to investigate the relation between mental adjustment to cancer and anxiety, depression, health-related quality of life (hrql) and survival in patients treated for laryngeal cancer. | 2011 | 21718478 |
| overexpression of sirt1 in mouse forebrain impairs lipid/glucose metabolism and motor function. | sirt1 plays crucial roles in glucose and lipid metabolism, and has various functions in different tissues including brain. the brain-specific sirt1 knockout mice display defects in somatotropic signaling, memory and synaptic plasticity. and the female mice without sirt1 in pomc neuron are more sensitive to diet-induced obesity. here we created transgenic mice overexpressing sirt1 in striatum and hippocampus under the control of camkii+¦ promoter. these mice, especially females, exhibited increas ... | 2011 | 21738790 |
| a preliminary report on the effects of the level of spinal cord injury on the association between central adiposity and metabolic profile. | to determine the effects of the level of injury on visceral adipose tissue (vat), subcutaneous adipose tissue (sat), and the vat:sat ratio in individuals with tetraplegia (t-spinal cord injury [sci]) and paraplegia (p-sci) and the relationships among central adiposity and glucose and lipid profile. | 2011 | 21570032 |
| anal canal cancer: management of inguinal nodes and benefit of prophylactic inguinal irradiation (cors-03 study). | purpose: to evaluate the benefit of prophylactic inguinal irradiation (pii) in anal canal squamous cell carcinoma (ascc). methods and materials: this retrospective study analyzed the outcome of 208 patients presenting with ascc treated between 2000 and 2004 in four cancer centers of the south of france. results: the population study included 35 t1, 86 t2, 59 t3, 20 t4, and 8 t stage unknown patients. twenty-seven patients presented with macroscopic inguinal node involvement. of the 181 patients ... | 2011 | 21570207 |
| moyamoya disease presenting as thalamic hemorrhage in a patient with neuromyelitis optica and sjögren's syndrome. | a 52-year-old woman was admitted to the hospital with right thalamic hemorrhage. a carotid angiogram revealed occlusion of the terminal portions of the bilateral internal carotid arteries with basal moyamoya vessels, which was diagnosed as moyamoya disease (mmd). at 31 years of age, she was diagnosed with multiple sclerosis because of optic neuritis and myelitis. paraplegia appeared 14 days after admission. t2-weighted thoracic magnetic resonance imaging revealed a high intensity lesion extendin ... | 2011 | 21571549 |
| the bacteriophage t4 rapid-lysis genes and their mutational proclivities. | like most phages with double-stranded dna, phage t4 exits the infected host cell by a lytic process requiring, at a minimum, an endolysin and a holin. unlike most phages, t4 can sense superinfection (which signals the depletion of uninfected host cells) and responds by delaying lysis and achieving an order-of-magnitude increase in burst size using a mechanism called lysis inhibition (lin). t4 r mutants that are unable to conduct lin produce distinctly large, sharp-edged plaques. the discovery of ... | 2011 | 21571993 |
| survival benefit of bursectomy in patients with resectable gastric cancer: interim analysis results of a randomized controlled trial. | background: bursectomy is regarded as a standard surgical procedure during gastrectomy for serosa-positive gastric cancer in japan. there is little evidence, however, that bursectomy has clinical benefit. we conducted a randomized controlled trial to demonstrate non-inferiority of treatment with the omission of bursectomy. methods: between july 2002 and january 2007, 210 patients with ct2-t3 gastric adenocarcinoma were intraoperatively randomized to radical gastrectomy and d2 lymphadenectomy wit ... | 2011 | 21573917 |
| impact of endothelial activation on infective and inflammatory complications after cardiac surgery in type ii diabetes mellitus. | purpose: altered endothelial response has been described in diabetics after cardiac surgery. infections and inflammatory organ damage often complicate the postoperative course. we evaluated endothelial/cytokine response (ecr) after cardiac surgery and its role on infective/inflammatory complications of type ii diabetic patients. ?methods: perioperative ecr of 60 diabetic patients (group a) undergoing cardiopulmonary bypass was compared to that of 60 non-diabetics (group b). hemodynamics, endothe ... | 2011 | 21574159 |
| [analysis of the therapeutic efficacy for 60 cases of t4 squamous cell carcinoma of the pyriform sinus]. | to evaluate the treatment results of t4 squamous cell carcinoma of the pyriform sinus. | 2011 | 21575488 |
| [surgery for t4 hypopharyngeal cancer and reconstruction after hypopharyngo-oesphagectomy.] | objective: to explore the surgical treatment of hypopharyngeal and cervical esophageal cancers and the ways of reconstruction after hypopharyngo-oesphagectomy, and to evaluate their efficacy. methods: twenty five patients with cancer of the laryngopharynx and cervical esophagus treated in our department between 1995 and 2007 were included in this study. their clinical data were restrspectively analyzed. among them, 17 cases had the tumor originated from the pyriform sinus, 3 of the posterior pha ... | 2011 | 21575524 |
| [effect of the populations of alabama argillacea (hübner) (lepidoptera: noctuidae) on cotton crop at two sowing distances.] | the objective of this research was to evaluate the incidence of damage by the leafworm alabama argillacea (hübner) on yields of cotton grown under rows spaced 0.38 m and 0.76 m at the irrigation area of santiago del estero, argentina. the period evaluated was extended from first flower to first open boll. treatments were t1 - without control of larvae, t2 - with control of larvae, t3 - control since first flower to the end of effective blooming, and t4 - with larval control since the end of effe ... | 2011 | 21584408 |
| splenic artery invasion in pancreatic adenocarcinoma of the body and tail: a novel prognostic parameter for patient selection. | background: the value of splenic vessels invasion (which identified t3 tumors) in prognosis after resection for pancreatic ductal adenocarcinoma (pda) of the body and tail has not been extensively investigated. the goal of this study was to evaluate prognostic factors in pda of the body/tail, emphasizing the role of splenic vessels infiltration. methods: between 1990 and 2008, 87 patients who underwent distal pancreatectomy (dp) for histologically proven pda of the body and tail were analyzed. c ... | 2011 | 21584836 |
| detection of bladder cancer using novel dna methylation biomarkers in urine sediments. | background: bladder cancer remains a lethal malignancy that can be cured if detected early. dna hypermethylation is a common epigenetic abnormality in cancer that may serve as a marker of disease activity.methods: we selected 10 novel candidate genes from the most frequently hypermethylated genes detected by dna microarray and bisulfite pyrosequencing of bladder cancers and applied them to detect bladder cancer in urine sediments. we analyzed dna methylation in the candidate genes by quantitativ ... | 2011 | 21586619 |
| peripheral nerve stimulation of the thoracic paravertebral plexus for chronic neuropathic pain. | persistent post surgical pain is reported in 70% of patients following thoracotomy and mastectomy. this pain is often neuropathic in nature and occasionally it is refractory to traditional medical and interventional management. neurostimulation of peripheral nerves can be a highly effective clinical modality for the management of neuropathic pain. the placement of a percutaneously sited electrode in the thoracic paravertebral plexus offers a new and novel mode of managing refractory thoracic neu ... | 2011 | 21587333 |
| thyroid hormone-induced haemoglobin changes and antioxidant enzymes response in erythrocytes. | thyroid hormones modulate haemoglobin and reactive oxygen species (ros) production, leading to antioxidant changes. this study evaluated the antioxidant response to ros in erythrocytes in hypothyroid and hyperthyroid rats. wistar rats were divided into four groups: control; hyperthyroid (t(4) -12 mg l(-1) in drinking water); sham operated (simulation of thyroidectomy); and hypothyroid (thyroidectomized). four weeks after, blood was collected and haemoglobin and t(4) levels, lipid peroxidation (l ... | 2011 | 21590696 |
| exaggeration is harder than understatement, but practice makes perfect! | previous research on the fakeability of the implicit association test (iat) yielded inconsistent results. the present study simultaneously analyses several relevant factors: faking direction, type of instructions, and practice. furthermore, it takes baseline individual differences into account. after a baseline assessment in a self-esteem iat without faking instructions (t0), participants in the faking conditions then (t1) faked high or low scores without being provided with recommended strategi ... | 2011 | 21592941 |
| long-term outcome of idiopathic hypertrophic thoracic pachymeningitis. | idiopathic hypertrophic spinal pachymeningitis (ihsp) is a comparatively rare disease characterized by hypertrophic inflammation of the dura mater and clinical symptoms that progress from local pain to myelopathy. we report a case of ihsp followed up for 20 years in a 46-year-old man. expansive laminoplasty was performed in 1991, and this case has been previously reported by a co-author. after 17 years, the patient's gait disturbance returned. physical examination and imaging confirmed ihsp that ... | 2011 | 21594749 |
| phase selection and site-selective distribution by tin and sulfur in supertetrahedral zinc gallium selenides. | doping is among the most important methods to tune the properties of semiconductors. for dense phase semiconductors, the distribution of dopant atoms in crystal lattices is often random. however, when the size of semiconductors becomes increasingly smaller and reaches the extreme situation as is the case in chalcogenide supertetrahedral clusters, different chemically distinct sites (e.g., corner, edge, face, and core) occur, which can dramatically affect the doping chemistry at different sites a ... | 2011 | 21595469 |
| [effect of the levels of vascular endothelial growth factor-a and c on the prognosis of patients with larynx carcinoma.] | objectives: in this study, we determined the prognostic importance of vascular endothelial growth factor (vegf)-a and c values and their relationship with tumor stages and neck lymp node involvement and also, the relationship between microvessel density and tumor stage in the pathologic specimens. patients and methods: thirty-three male patients (mean age 57.8±7.2 years; range 49 to 69 years) who underwent surgical treatment for laryngeal squamous cell carcinoma and a control group of 13 healthy ... | 2011 | 21595615 |
| midkine expression in oral squamous cell carcinoma and leukoplakia. | j oral pathol med (2011) background: midkine (mk), a 13-kda heparin-binding growth factor, is overexpressed in various human cancers. however, its role in the development and progression of oral cavity squamous cell carcinoma (ocscc) is still unclear. thus, the aim of this study was to evaluate the expression of mk in samples of ocscc, leukoplakia, and healthy oral mucosa (control). methods: surgically excised specimens from patients with primary ocscc (n = 28) were immunostained for mk, ki-67 ... | 2011 | 21595751 |
| hypothyroidism caused by phenobarbital affects patterns of estrous cyclicity in rats. | we found that repeated treatment with phenobarbital (pb), a thyroid modulator, resulted in a persistent estrous stage in the present study. although the effects of pb in blocking the surge release of luteinizing hormone (lh), inducing anovulation and prolonging the diestrous period has been well established, there is still no research describing the appearance of persistent estrous states in normal cycling rats dosed with pb. to further study this phenomenon, female rats exhibiting regular estro ... | 2011 | 21595753 |
| acute and chronic hypothyroidism are associated with similar left ventricular diastolic dysfunction relative to the euthyroid state: results of doppler echocardiographic comparisons. | background: how the duration of hypothyroidism affects left ventricular diastolic function is not well-characterized. aim: we sought to compare left ventricular diastolic function in acutely vs. chronically hypothyroid patients vs. euthyroid controls, and within individuals while on vs. off t4. subjects and methods: we prospectively performed such comparisons measuring pulsed-wave and color m-mode doppler echocardiographic variables: early or late mitral peak velocities (e wave or a wave, respec ... | 2011 | 21597313 |
| presynaptic filament dynamics in homologous recombination and dna repair. | homologous recombination (hr) is an essential genome stability mechanism used for high-fidelity repair of dna double-strand breaks and for the recovery of stalled or collapsed dna replication forks. the crucial homology search and dna strand exchange steps of hr are catalyzed by presynaptic filaments-helical filaments of a recombinase enzyme bound to single-stranded dna (ssdna). presynaptic filaments are fundamentally dynamic structures, the assembly, catalytic turnover, and disassembly of which ... | 2011 | 21599536 |
| [effect of remifentanil or esmolol on stress response during electric shock therapy in psychiatric patients]. | to observe the effects of remifentanil or esmolol on the stress responses during electric shock therapy in psychiatric patients. | 2011 | 21600104 |
| [effect of pediatric tci system for propofol plus remifentanil in pediatric short-duration surgery with laryngeal mask airway anesthesia]. | to study the effect of a pediatric tci patent system for propofol plus remifentanil in pediatric short-duration surgery with laryngeal mask airway (lma) anesthesia. | 2011 | 21600128 |
| survival of prototype strains of somatic coliphage families in environmental waters and when exposed to uv low-pressure monochromatic radiation or heat. | the potential use of specific somatic coliphage taxonomic groups as viral indicators based on their persistence and prevalence in water was investigated. representative type strains of the 4 major somatic coliphage taxonomic groups were seeded into reagent water and an ambient surface water source of drinking water and the survival of the added phages was measured over 90 days at temperatures of 23-25 and 4 °c. microviridae (type strain phix174), siphoviridae (type strain lambda), and myoviridae ... | 2011 | 21600626 |
| effect of age on transitional cell carcinoma of the upper urinary tract: presentation, treatment, and outcomes. | objectives: to determine the effect of age on the disease characteristics, treatment administered, and disease-specific survival (dss) for patients with upper tract urothelial carcinoma. the effect of advancing age on the disease extent and survival has not been well delineated in patients with upper tract urothelial carcinoma. methods: using the surveillance, epidemiology, and end results database from the national cancer institute, we identified patients diagnosed with utuc from 1984 to 2004. ... | 2011 | 21601253 |
| enzymatic assembly of overlapping dna fragments. | three methods for assembling multiple, overlapping dna molecules are described. each method shares the same basic approach: (i) an exonuclease removes nucleotides from the ends of double-stranded (ds) dna molecules, exposing complementary single-stranded (ss) dna overhangs that are specifically annealed; (ii) the ssdna gaps of the joined molecules are filled in by dna polymerase, and the nicks are covalently sealed by dna ligase. the first method employs the 3'-exonuclease activity of t4 dna pol ... | 2011 | 21601685 |
| does the nerve of kuntz exist? | a best evidence topic was written according to a structured protocol. the question addressed was, in what proportion of patients is the nerve of kuntz identifiable? a total of 55 papers were found using the reported search, of which six represented the best evidence to answer the clinical question. the authors, date, journal, study type, population, main outcome measures and results are tabulated. the nerve of kuntz was originally described in 1927 as being a connection from the second intercost ... | 2011 | 21602419 |
| [construction of replication-deficient recombinant adenovirus vector with htfpi-2 gene by admax system and expression in u937 monocytes in vitro]. | we tried to construct and identify the recombinant replication-deficient adenovirus vector coding for human tissue factor pathway inhibitor 2 (htfpi-2) gene by admax system in hek293 cells. firstly, we obtained htfpi-2 gene from the recombinant plasmid pires2-egfp-tfpi-2 by pcr using primers with restriction endonuclease site of ecori or saci. after digesting the htfpi-2 gene and plasmid pdc316-ires-egfp shuttle vector, we ligated them with t4 ligase and formed the recombinant shuttle vector pdc ... | 2011 | 21604496 |
| a freshwater cyanophage whose genome indicates close relationships to photosynthetic marine cyanomyophages. | bacteriophage s-crm01 has been isolated from a freshwater strain of synechococcus and shown to be present in the upper klamath river valley in northern california and oregon. the genome of this lytic t4-like phage has a 178 563 bp circular genetic map with 297 predicted protein-coding genes and 33 trna genes that represent all 20-amino-acid specificities. analyses based on gene sequence and gene content indicate a close phylogenetic relationship to the 'photosynthetic' marine cyanomyophages infe ... | 2011 | 21605306 |
| cell-free synthesis of a functional g protein-coupled receptor complexed with nanometer scale bilayer discs. | abstract: background: g protein coupled receptors (gpcrs) represent the largest family of membrane proteins in the human genome and the richest source of targets for the pharmaceutical industry. a major limitation to characterizing gpcrs has been the difficulty in developing high-level heterologous expression systems that are cost effective. reasons for these difficulties include inefficient transport and insertion in the plasma membrane and cytotoxicity. additionally, gpcr purification requires ... | 2011 | 21605442 |
| graves' disease: diagnostic and therapeutic challenges (multimedia activity). | graves' disease is the most common cause of hyperthyroidism in the united states. graves' disease occurs more often in women with a female:male ratio of 5:1 and a population prevalence of 1% to 2%. a genetic determinant to the susceptibility to graves' disease is suspected because of familial clustering of the disease, a high sibling recurrence risk, the familial occurrence of thyroid autoantibodies, and the 30% concordance in disease status between identical twins. graves' disease is an autoimm ... | 2011 | 21605717 |
| surgery of pancreatic cancer in the new millennium: better prediction of outcome. | background:: surgery is the only therapy with potentially curative intention in pancreatic cancer. this analysis aimed to determine prognostic parameters in a patient cohort with resected pancreatic adenocarcinoma with a special focus on the revised r1-definition. methods:: between october 2001 and august 2009, data from 1071 consecutively resected patients with pancreatic adenocarcinoma were prospectively collected in an electronical database. parameters tested for survival prediction in univar ... | 2011 | 21606835 |
| factors influencing bone loss in paraplegia. | background and aim: significant bone loss develops in the first months and continues years after spinal cord injury. a cross - sectional comparative study was performed to evaluate factors influencing bone loss in spinal cord injured men with paraplegia.patients and methods: we studied 31 paraplegic men in chronic stage (>1.5 years) in comparison with 30 able-bodied men of similar age, height, and weight. the paraplegic men were allocated into 2 subgroups based on the neurological level of injur ... | 2011 | 21607037 |
| the role of tumor size and patient's age as prognostic factors in laryngeal cancer. | background and aim: the loco-regional recurrence of laryngeal carcinoma in patients who underwent total laryngectomy is related to numerous factors. aim of the present study was to investigate the role of patient's age and tumor size in the recurrence rate of patients. additional aim of the current study was to investigate the possible associations between the size of the tumor and other characteristics.patients and methods: in 1st department of otorhinolaryngology of ahepa university hospital, ... | 2011 | 21607041 |
| spect/ct imaging in children with papillary thyroid carcinoma. | background: spect/ct improves localization of single photon-emitting radiopharmaceuticals. objective: to determine the utility of spect/ct in children with papillary thyroid carcinoma. materials and methods: 20 spect/ct and planar studies were reviewed in 13 children with papillary thyroid carcinoma after total thyroidectomy. seven studies used i-123 and 13 used i-131, after elevating tsh by t4 deprivation or intramuscular thyrotropin alfa. eight children had one study and five children had two ... | 2011 | 21607603 |
| [effects of different film mulch and ridge-furrow cropping patterns on yield formation and water translocation of rainfed potato]. | this paper studied the effects of different film mulch and ridge-furrow cropping patterns on the yield formation and water translocation of rainfed potato in the semi-arid area of west loess plateau. comparing with those under traditional harrowed bedding without film mulch (t1), the potato yield under harrowed bedding with film mulching (t2), completely mulched alternating narrow and wide ridges with furrow planting (t3), completely mulched alternating narrow and wide ridges with ridge planting ... | 2011 | 21608252 |
| [a retrospective analysis of clinicopathological characteristics and prognostic factors of gastric stump cancer]. | to explore the clinicopathological characteristics and prognostic factors of gastric stump cancer(gsc). | 2011 | 21609561 |
| an interaction between the walker a and d-loop motifs is critical to atp hydrolysis and cooperativity in bacteriophage t4 rad50. | the atp binding cassette (abc) proteins make up a large superfamily with members coming from all kingdoms. the functional form of the abc protein nucleotide binding domain (nbd) is dimeric with atp binding sites shared between subunits. the nbd is defined by six motifs: the walker a, q-loop, signature, walker-b, d-loop, and h-loop. the d-loop contains a conserved aspartate whose function is not clear but has been proposed to be involved in cross-talk between atp binding sites. structures of vari ... | 2011 | 21610075 |
| a facile method for the assessment of dna damage induced by uv-activated nanomaterials. | fluorescent microscopy observation of gene-size dna (t4 phage dna or λ phage dna) was used to assess dna damage induced by uv irradiation in the presence of nanomaterials, such as qds (quantum dots: cdse/zns semiconductor nanoparticles), the water-soluble fullerene derivative c(60)(oh)(n) (n = 6-12) and titanium oxide nanoparticles of 25 nm in diameter. the magnitude of dna damage could be simply evaluated based on the degree of shortening of the stretched dna image. this method showed that dna ... | 2011 | 21614347 |
| the complete genome sequence of a novel t4-like bacteriophage, ime08. | 2011 | 21614434 | |
| expression analysis of prestin and selected transcription factors in newborn rats. | transcription factors (tfs) have a central role to play in regulating gene expression. to analyze the co-expression patterns of selected tfs with the motor protein prestin of the outer hair cells, we applied an real-time pcr approach combining several kinds of information: (i) expression changes during postnatal development, (ii) expression changes by exposure of organotypic cultures of the organ of corti to factors which significantly affect prestin expression [thyroid hormone (t4), retinoic ac ... | 2011 | 21614551 |
| adenocarcinoma of the ethmoid sinus: retrospective study of 42 cases. | objectives: retrospective analysis of the oncological results and morbidity of ethmoid sinus adenocarcinoma surgery, and identification of survival factors. material and methods: forty-two patients were treated from 1990 to 2009. the study covered clinical presentation, medical imaging, histologic data, tnm grade, treatment, morbidity and overall recurrence-free survival. results: forty-one men and one woman, with mean age at diagnosis of 61.5 years, were included. 85.7% had been exposed to wood ... | 2011 | 21616740 |
| [the role of chemotherapy in the management of bladder cancer.] | bladder cancer represents for man the second genitourinary cancer after prostate cancer. urothelial carcinoma is the most predominant histological type. in up to 70% of the cases, the diagnosis of bladder cancer is performed at early stages (ta-t1). in this situation, the treatment of the disease is the transurethral resection with or without intravesical treatment (bcg, amiticyne). in advanced disease, treatment is essentially palliative with chemotherapy based on cisplatin type mvac (methotrex ... | 2011 | 21620296 |
| neoadjuvant chemoradiation for clinically advanced non-small cell lung cancer: an analysis of 233 patients. | background: surgical intervention after chemoradiation for locoregionally advanced non-small cell lung cancer (nsclc) is controversial. this study evaluated patient survival after neoadjuvant chemoradiation and anatomic pulmonary resections for locoregionally advanced nsclc. methods: clinicopathologic data were retrospectively collected for 233 patients (110 women, 123 men) with nsclc who underwent chemoradiation therapy, followed by pneumonectomy, sleeve lobectomy, bilobectomy, and standard lob ... | 2011 | 21620372 |
| the role of laparoscopic and robotic cystectomy in the management of muscle-invasive bladder cancer with special emphasis on cancer control and complications. | context: minimally invasive radical cystectomy (mirc) techniques for the treatment of muscle-invasive bladder cancer (bca) are being increasingly applied. mirc offers the potential benefits of a minimally invasive approach in terms of reduced blood loss and analgesic requirements whilst striving to provide similar oncologic efficacy to open radical cystectomy (orc). whether quicker recovery, shorter hospital stay, and a reduction in complications are routinely achieved with mirc remains to be pr ... | 2011 | 21620562 |
| proposal of new nodal classifications for non-small-cell lung cancer based on the number and ratio of metastatic lymph nodes. | objective: the study aimed to evaluate the effectiveness of two new nodal classifications based on the number of metastatic lymph nodes (lns) or ratio of metastatic to examined lns (lnr) in making a prognosis, compared with the current nodal classification based on the location of metastatic lns. methods: we analyzed 651 non-small-cell lung cancer patients who had undergone complete resection with the removal of more than five lns between 1986 and 2003, excluding preoperative treatment cases, an ... | 2011 | 21620720 |
| changes in life style improve body composition, thyroid function and structure in obese children. | background. alterations in thyroid function and structure have been reported in obesity. function reverses to normal after weight loss, but nothing is known about structure. aim. to evaluate the effect of weight loss on thyroid function and structure in obese children. subjects and methods: the study was conducted in 72 overweight and obese children. measurement of ft3, ft4, tsh, antithyroid-antibodies and a thyroid ultrasound was performed at the beginning (phase 1) and after a period of 1.8 ± ... | 2011 | 21623157 |
| long-term results of salvage photodynamic therapy for patients with local failure after chemoradiotherapy for esophageal squamous cell carcinoma. | background and study aims: local failure after chemoradiotherapy (crt) remains a major problem for patients with esophageal squamous cell carcinoma (escc). the aim of this study was to clarify the long-term results of salvage photodynamic therapy (pdt) for local failure. patients and methods: patients were treated with crt, consisting of more than 50 gy irradiation and concurrent chemotherapy. the indications for salvage pdt were as follows: 1) absence of lymph-node or distant metastasis after c ... | 2011 | 21623555 |
| a retrospective study of salvage surgery for recurrent nasopharyngeal carcinoma. | background: nasopharyngeal carcinoma is sensitive to radiotherapy. when there is local relapse, re-irradiation treatment is inevitably associated with serious complications and decreased quality of life. surgical resection offers an alternative treatment option with acceptable morbidity. methods: seventy-one consecutive patients with primary recurrence of nasopharyngeal carcinoma after radiation underwent nasopharyngectomy from january 1, 1990 to june 30, 2006. follow-up ranged from 12 to 127-ám ... | 2011 | 21710155 |
| structural basis for sequence specific dna binding and protein dimerization of hoxa13. | the homeobox gene (hoxa13) codes for a transcription factor protein that binds to at-rich dna sequences and controls expression of genes during embryonic morphogenesis. here we present the nmr structure of hoxa13 homeodomain (a13dbd) bound to an 11-mer dna duplex. a13dbd forms a dimer that binds to dna with a dissociation constant of 7.5 nm. the a13dbd/dna complex has a molar mass of 35 kda consistent with two molecules of dna bound at both ends of the a13dbd dimer. a13dbd contains an n-terminal ... | 2011 | 21829694 |
| a polymorphism of the polg2 gene is genetically associated with the invasiveness of urinary bladder cancer in japanese males. | urinary bladder cancer (ubc) is a common cancer with male predominance. pathologically it is classified into two distinct tumor entities related to the risk of patients. the low-grade tumors with relatively well-differentiated tumor histology (g1 and g2) at stage ta are non-invasive and pose a minimal risk, whereas high-grade tumors (g2 and g3) with stages t1 to t4 are aggressive with invasion, and therefore, pose a serious risk for the patients. dna repair and metabolic process genes may have m ... | 2011 | 21734712 |