Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| acute retinal necrosis following epidural steroid injections. | to report a side effect of epidural corticosteroid injections for back pain. | 2003 | 12834695 |
| varicella infection in a pediatric aids patient presenting as umbilicated papules. | an 8-year-old girl with acquired immunodeficiency syndrome presented with fever and alteration of consciousness. she had a history of persistent cryptococcal meningitis. she developed multiple discrete umbilicated papules that resembled cutaneous cryptococcosis on the second day of admission. skin biopsy revealed an ulcer with a wedge-shaped necrosis of the dermis. the edge of the ulcer showed intracellular edema, margination of nucleoplasm and multinucleated cells, consistent with herpes infect ... | 2003 | 12931753 |
| severe acute visceral pain from varicella zoster virus. | varicella zoster virus infection often will not present in the characteristic dermatomal distribution of vesicles in patients who have undergone bone marrow transplantation. we cared for a 51-yr-old man with severe abdominal pain after bone marrow transplantation for non-hodgkin's lymphoma. the diagnosis of varicella zoster was not entertained until he developed a diffuse vesicular rash several days after the onset of pain. we report this case to alert others who may be consulted regarding pain ... | 2003 | 14500167 |
| shingles: when a slumbering virus stirs. | 2003 | 14505966 | |
| effects of a behavioral intervention, tai chi chih, on varicella-zoster virus specific immunity and health functioning in older adults. | both the incidence and severity of herpes zoster (shingles) increase markedly with increasing age in association with a decline in varicella-zoster virus (vzv) specific cell-mediated immunity (cmi). this study examined whether a behavioral intervention, tai chi chih (tcc), affects vzv specific immunity and health functioning in older adults who, on average, show impairments of health status and are at risk for shingles. | 2003 | 14508027 |
| oligoclonal immunoglobulins in cerebrospinal fluid during varicella zoster virus (vzv) vasculopathy are directed against vzv. | limited analyses of cerebrospinal fluid from patients with central nervous system infections have shown that the oligoclonal igg is antibody directed against the agent that causes disease. using a new method involving binding of igg to beads coated with lysates prepared from candidate infectious antigens, we showed that the oligoclonal igg in cerebrospinal fluid of a patient with chronic varicella zoster virus vasculopathy is directed against the causative virus. this approach holds promise in i ... | 2003 | 14520657 |
| co-detection and discrimination of six human herpesviruses by multiplex pcr-elaha. | herpesviruses are a significant cause of human morbidity. traditional approaches to the identification of these viruses require infectious or at least antigenic virus. multiplex pcr (mpcr) is capable of simultaneously amplifying a range of targets from a single preparation of nucleic acids and when combined with a suitable detection assay, it is capable of discriminating each of the amplicons. | 2003 | 14522068 |
| clinical potential of the acyclic nucleoside phosphonates cidofovir, adefovir, and tenofovir in treatment of dna virus and retrovirus infections. | the acyclic nucleoside phosphonates hpmpc (cidofovir), pmea (adefovir), and pmpa (tenofovir) have proved to be effective in vitro (cell culture systems) and in vivo (animal models and clinical studies) against a wide variety of dna virus and retrovirus infections: cidofovir against herpesvirus (herpes simplex virus types 1 and 2 varicella-zoster virus, cytomegalovirus [cmv], epstein-barr virus, and human herpesviruses 6, 7, and 8), polyomavirus, papillomavirus, adenovirus, and poxvirus (variola ... | 2003 | 14557287 |
| absence of detection of varicella-zoster virus dna in temporal artery biopsies obtained from patients with giant cell arteritis. | it has been suggested that varicella-zoster virus (vzv) may play a role in the pathogenesis of giant cell arteritis (gca). we therefore used both in situ hybridisation and in situ polymerase chain reaction amplification techniques in an attempt to identify vzv dna in 15 temporal arteries from histologically proven gca. we did not detect evidence of vzv dna in the arteries of any of these subjects, nor in temporal arteries obtained from seven normal control subjects. vzv was detected, however, in ... | 2003 | 14568124 |
| new antiviral drugs that target herpesvirus helicase primase enzymes. | herpesviruses have infected the majority of the world's population and the associated diseases have plagued humanity since ancient times. nine causative human herpesviruses have been identified so far. the first antiviral drug was launched in 1962, and since then several drugs for treating herpesvirus infections, which work via different mechanisms, have been developed. current treatments abrogate or suppress disease symptoms but are not curative. a vaccine based on the oka strain of varicella z ... | 2003 | 14577954 |
| requirement of varicella-zoster virus immediate-early 4 protein for viral replication. | varicella-zoster virus (vzv) is an alphaherpesvirus that causes two diseases, chickenpox and zoster. vzv open reading frame 4 (orf4) encodes the immediate-early 4 (ie4) protein, which is conserved among alphaherpesvirus and has transactivation activity in transient transfections. to determine whether the orf4 gene product is essential for viral replication, we used vzv cosmids to remove orf4 from the vzv genome. deleting orf4 was incompatible with recovery of infectious virus, whereas transfecti ... | 2003 | 14581575 |
| synthesis and antiviral activities of 3-aralkylthiomethylimidazo[1,2-b]pyridazine derivatives. | the synthesis of novel substituted 3-aralkylthiomethylimidazo[1,2-b]pyridazines is reported. all of the synthesized compounds are devoid of antiviral activity against the replication of human immunodeficiency virus. however, compounds 6-chloro-8-methyl-3-phenethylthioimidazo[1,2-b]pyridazine and 6-chloro-2-methyl-3-phenethylthioimidazo[1,2-b]pyridazine are potent inhibitors of the replication of human cytomegalovirus in vitro, while compounds 6-chloro-2-methyl-3-benzylthiomethylimidazo[1,2-b]pyr ... | 2003 | 14582846 |
| 5-substituted-2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidines-acyclic nucleoside phosphonate analogues with antiviral activity. | 2,4-diamino-6-hydroxypyrimidines substituted in position 5 by an allyl, benzyl, cyanomethyl, ethoxycarbonylmethyl, phenyl, cyclopropyl, or methyl group were prepared either by c5-alkylation or by formation of the pyrimidine ring by cyclization. their alkylation with 2-[(diisopropoxyphosphoryl)methoxy]ethyl tosylate afforded n1- and o6-regioisomers that were separated and converted to the free phosphonic acids by treatment with bromotrimethylsilane followed by hydrolysis. reaction of 2,4-diamino- ... | 2003 | 14584956 |
| decline in varicella-zoster virus (vzv)-specific cell-mediated immunity with increasing age and boosting with a high-dose vzv vaccine. | the safety and immunogenecity of a booster dose of live attenuated varicella-zoster virus (vzv) vaccine was evaluated in 196 healthy subjects, >or=60 years old, who had already received a vzv vaccine >5 years before. this repeat booster dose was well tolerated. cell-mediated immunity (cmi) to vzv was measured by an interferon-gamma (ifn-gamma) enzyme-linked immunosorbent spot-forming cell (elispot) assay and a limiting dilution responder cell frequency (rcf) assay. prevaccination responses decre ... | 2003 | 14593591 |
| superiority of varicella skin test antigen over purified varicella-zoster virus glycoproteins in monitoring booster response to oka varicella vaccine. | varicella skin test antigen has been developed based on the induction of delayed-type hypersensitivity (dth) to varicella-zoster virus (vzv). the booster immune response to oka varicella vaccine was assessed by cutaneous reactivity to purified vzv glycoprotein complexes, gb, ge:gi, gh:gl, and varicella skin test antigen. skin tests with these antigens significantly augmented antibody production to glycoproteins and vzv antigen resulting in no further augmentation by the subsequent vaccination. a ... | 2003 | 14604566 |
| immunogenicity and reactogenicity of a single dose of live attenuated varicella vaccine and a booster dose of measles-mumps-rubella vaccine given concomitantly at 12 years of age. | universal varicella-zoster virus (vzv) childhood vaccination is still debated, but adult chickenpox may be severe. it could be prevented by vaccination of seronegative adolescents. this study aimed to determine the feasibility of coadministration of a vzv vaccine and the measles-mumps-rubella (mmr) booster at 12 y of age. guardians of 1231 12-y-old pupils where asked about the history of chickenpox in their children. 190 had no chickenpox history and 12 of 62 of them lacked vzv antibodies. addit ... | 2003 | 14606613 |
| latent herpesvirus infection in human trigeminal ganglia causes chronic immune response. | the majority of trigeminal ganglia (tgs) are latently infected with alpha-herpesviruses [herpes simplex virus type-1 (hsv-1) and varicella-zoster virus (vzv)]. whereas hsv-1 periodically reactivates in the tgs, vzv reactivates very rarely. the goal of this study was to determine whether herpesvirus latency is linked to a local immune cell infiltration in human tgs. t cells positive for the cd3 and cd8 markers, and cd68-positive macrophages were found in 30 of 42 examined tgs from 21 healthy indi ... | 2003 | 14633592 |
| herpes simplex virus type 1 infection associated with atrial myxoma. | some findings suggest an infectious factor in cardiac myxoma and certain histopathological features indicate herpes simplex virus type 1 (hsv-1) infection. we hypothesized that hsv-1 may be involved in the pathogenesis of cardiac myxoma. paraffin-embedded tissue samples from 17 patients with atrial myxoma were investigated for hsv-1 antigen by immunohistochemistry and viral genomic dna by nested polymerase chain reaction. the histogenesis and oncogenesis of atrial myxoma were assessed by the exp ... | 2003 | 14633612 |
| non-hiv antivirals - a review of the recent patent literature. | this review covers the non-hiv antiviral patent literature from december 2001 to april 2002. most of the patent applications describe new compounds for the treatment of hepatitis c virus (hcv) by inhibition of the ns3 serine protease. several examples of both nucleoside and non-nucleoside inhibitors of the hcv polymerase ns5b have been reported. hepatitis b virus (hbv) therapy continues to be dominated by nucleoside analogs, but several non-nucleoside hbv polymerase inhibitors have also been rep ... | 2002 | 12802698 |
| which children and adults should receive the chickenpox vaccine? | chickenpox vaccine is safe and effective and elicits long-standing immunity. primary care physicians caring for children and adults should be aware of its benefits. | 2002 | 12546274 |
| outbreak of varicella at a day-care center despite vaccination. | in seven studies of the effectiveness of the varicella vaccine conducted since it was licensed, the effectiveness was 71 to 100 percent against disease of any severity and 95 to 100 percent against moderate and severe disease. we investigated an outbreak of varicella in a population of children with a high proportion of vaccinees who were attending a day-care center in a small community in new hampshire. | 2002 | 12477940 |
| detection of herpes simplex virus in pseudoexfoliation syndrome and exfoliation glaucoma. | the pathogenesis of pseudoexfoliation syndrome (pex) remains unknown. an infection, possibly viral, is one of the proposed pathogenetic mechanisms. this study examines the presence of herpes simplex virus (hsv) and varicella-zoster virus (vzv) in iris and anterior capsule specimens of pex and non-pex patients. | 2002 | 12485281 |
| association of hla-a*3303-b*4403-drb1*1302 haplotype, but not of tnfa promoter and nkp30 polymorphism, with postherpetic neuralgia (phn) in the japanese population. | herpes zoster is a common disease caused by reactivation of the varicella zoster virus (vzv). in a small number of herpes zoster patients, pain persists beyond 4 weeks or more after healing of vesicular eruptions; this condition is termed postherpetic neuralgia (phn). positive associations of human histocompatibility leukocyte antigens (hla) class i antigens, a33 and b44, with phn in the japanese population have been reported. our hypothesis is that susceptibility genes to phn might exist in the ... | 2002 | 12486606 |
| the protean manifestations of varicella-zoster virus vasculopathy. | varicella-zoster virus (vzv) vasculopathy in the central nervous system (cns) affects large and small cerebral vessels. large-vessel disease is most common in immunocompetent individuals, whereas small-vessel disease usually develops in immunocompromised patients. in some patients, both large and small vessels are involved. neurological features are protean. neurological disease often occurs months after zoster and sometimes without any history of zoster rash. magnetic resonance imaging (mri) sc ... | 2002 | 12491155 |
| [a case of ramsay hunt syndrome initiated with hoarseness and dysphagia: consideration on spreading mechanisms of cranial neuropathy]. | a 85-year-old woman was admitted to our hospital because of progressive hoarseness and dysphagia of two days' duration. neurological examination on admission revealed right pharyngeal and vocal cord palsies. after admission, gradual swelling of her right ear was noted, and on day 6, vesicular eruptions in her right geniculate zone, the right vii and the viiith cranial nerve palsies were added. on the basis of these findings, she was diagnosed as ramsay hunt syndrome. varicella zoster virus (vzv) ... | 2002 | 12710084 |
| vaccination with varicella protects against zoster infection. | 2002 | 12217782 | |
| histologic and in situ viral findings in the myocardium in cases of sudden, unexpected death. | the purpose of this study was to do in situ viral detection in myocardial tissues of individuals who suffered sudden unexpected death and to correlate the results with the postmortem histopathologic findings. thirteen cases were identified and the heart tissues were analyzed for adenovirus, cytomegalovirus, epstein barr virus, herpes simplex virus 1 and 2, human immunodeficiency virus 1 (hiv-1), influenza a, influenza b, parvovirus, rotavirus, picornavirus (including separate primers for enterov ... | 2002 | 12218208 |
| varicella zoster viraemia during herpes zoster is not associated with neoplasia. | shingles are caused by an endogenous or exogenous reinfection with varicella zoster virus (vzv). up to 50% of individuals with hodgkin's disease develop herpes zoster; however, no association could be shown between the occurrence of herpes zoster and underlying subclinical malignancies. | 2002 | 12224692 |
| [necrosis of the nose tip]. | 2002 | 12233008 | |
| chickenpox and the geniculate ganglion: facial nerve palsy, ramsay hunt syndrome and acyclovir treatment. | facial nerve palsy has long been considered to have an infectious etiology. recent diagnostic analyses in children and adults have provided convincing evidence that reactivation of varicella-zoster virus (vzv), sometimes during infectious mononucleosis, can lead to cranial nerve vii palsy. the site of reactivation from latency is the geniculate ganglion. virus most likely enters the ganglion during chickenpox, via the sensory branches of the facial nerve located on the ear and tongue. retrospect ... | 2002 | 12237590 |
| varicella-zoster virus: atypical presentations and unusual complications. | varicella-zoster virus (vzv) is the etiologic agent of varicella (primary infection) and herpes zoster (reactivation of latent infection). although varicella is most often a relatively benign and self-limited childhood illness, the disease can be associated with a variety of serious and potentially lethal complications in both immunocompetent and immunocompromised persons. one complication of varicella that appears to be increasing in frequency is serious bacterial soft tissue infections caused ... | 2002 | 12353193 |
| visceral varicella zoster after bone marrow transplantation: an obscure cause of an "acute abdomen". | 2002 | 12353837 | |
| rapid molecular discrimination between infection with wild-type varicella-zoster virus and varicella vaccine virus. | varicella-zoster virus (vzv) infection is immunocompromised patients may cause life-threatening complications. prevention measures include administration of vzv immuloglobulin, acyclovir and live attenuated varicella vaccine. after vaccination, a mild varicella-like exanthem appears in up to 5% of vaccinees. morphologically this exanthem cannot be differentiated from wild-type (wt) varicella. the risk of virus transmission after varicella vaccination, in contrast to wt varicella, is low, even in ... | 2002 | 12382096 |
| tropism of varicella-zoster virus for human tonsillar cd4(+) t lymphocytes that express activation, memory, and skin homing markers. | varicella-zoster virus (vzv) is an alphaherpesvirus with the characteristic neurotropism of this group, but vzv also infects t cells productively and downregulates major histocompatibility complex (mhc) class i expression on infected t cells, as shown in the scid-hu mouse model. t-cell tropism is likely to be critical for the cell-associated viremia associated with primary vzv infection. in these experiments, we found that vzv infects human tonsillar cd4(+) t cells in culture, with 15 to 25% bei ... | 2002 | 12388703 |
| comparison of the complete dna sequences of the oka varicella vaccine and its parental virus. | the dna sequences of the oka varicella vaccine virus (v-oka) and its parental virus (p-oka) were completed. comparison of the sequences revealed 42 base substitutions, which led to 20 amino acid conversions and length differences in tandem repeat regions (r1, r3, and r4) and in an origin of dna replication. amino acid substitutions existed in open reading frames (orfs) 6, 9a, 10, 21, 31, 39, 50, 52, 55, 59, 62, and 64. of these, 15 base substitutions, leading to eight amino acid substitutions, w ... | 2002 | 12388706 |
| responses of varicella zoster virus (vzv)-specific immunity in seropositive adults after inhalation of inactivated or live attenuated varicella vaccine. | to examine boostering of varicella zoster virus (vzv)-specific immunity in seropositive adults after nasal inhalation of heat-inactivated or live attenuated varicella vaccine, we determined specific cellular immunity, igg antibody in sera and secretory iga antibody in saliva before and after the inhalation. the mean titers in specific igg antibody and skin test findings significantly increased following inhalation of both vaccines. however, the ratio of a two-fold or more increase in the levels ... | 2002 | 12399190 |
| herpes viruses hedge their bets. | static latency is the hallmark of all herpes viruses. the varicella zoster virus, for instance, causes varicella (chickenpox), and after a latent phase of between 5 and 40 years, it can give rise to herpes zoster (shingles). this latency and the subsequent reactivation has intrigued and puzzled virologists. although several factors have been suggested, it is unknown what triggers reactivation. however, latency can be explained with a simple evolutionary model. here, we demonstrate that a simple, ... | 2002 | 12409612 |
| can varicella be eliminated by vaccination? potential clinical and economic effects of universal childhood varicella immunisation in germany. | varicella is a potentially serious infection not only in immunocompromised individuals but also in otherwise healthy adults and children. vaccination plays an important role in preventing the disease and its sequelae. a universal vaccination in childhood is expected to reduce substantially the number of uncomplicated cases of varicella and decrease the number of complicated cases requiring hospitalisation. to generate data as basis for decisions of the health authorities concerning prevention of ... | 2002 | 12410347 |
| two patients with unusual forms of varicella-zoster virus vasculopathy. | 2002 | 12421892 | |
| torch agents in pregnant saudi women. | to determine the seroprevalence rates of igg to common torch agents in pregnant saudi women using indirect enzyme-linked immunosorbent assay. | 2002 | 12424411 |
| physical and functional interaction between the varicella zoster virus ie63 and ie62 proteins. | the varicella zoster virus (vzv) ie63 protein is required for growth of the virus in cell culture and is expressed during both lytic and latent phases of vzv infection. we have investigated the physical and functional interaction of this protein with the major vzv transactivating protein ie62. the region of the ie63 protein required for interaction with the ie62 protein has been identified and encompasses the n-terminal 142 amino acids. we have found that the interaction is stable at physiologic ... | 2002 | 12429517 |
| viral titers and delayed facial palsy after acoustic neuroma surgery. | delayed facial palsy (dfp) after acoustic neuroma surgery has been reported to occur in up to one third of cases. reactivation of latent virus has been proposed as an etiology for dfp. however, only retrospective case reports and case series have offered data to support this theory. the objective of this study was to correlate dfp with change in viral titers. patients and methods: twenty consecutive patients who underwent acoustic neuroma surgery were prospectively evaluated for viral titers imm ... | 2002 | 12447236 |
| role of cidofovir in the treatment of dna virus infections, other than cmv infections, in immunocompromised patients. | cidofovir is a nucleotide analog marketed for the treatment of human cytomegalovirus infections in immunocompromised patients. an increasing number of reports have appeared on the use of cidofovir for the treatment of other severe dna virus infections in immunocompromised patients. the activity of cidofovir against herpes simplex viruses resistant to classic (acyclovir and/or foscavir) therapy has been widely documented. cidofovir has also been used for the treatment of other herpesvirus infecti ... | 2002 | 12476953 |
| cv-1 and mrc-5 mixed cells for simultaneous detection of herpes simplex viruses and varicella zoster virus in skin lesions. | culture for varicella zoster virus (vzv) is relatively insensitive. herpes simplex viruses (hsv) culture methods, which rely on primary rabbit kidney (prk), mink lung (mv1lu) or the elvis hsv culture system fail to detect vzv. culture of atypical vesicular skin lesions should be able to detect both hsv and vzv. | 2002 | 11744427 |
| studies on shingles, is the virus ordinary chickenpox virus? | 2002 | 11787080 | |
| presumed reactivation of herpes zoster ophthalmicus following laser in situ keratomileusis. | to report a case of herpes zoster ophthalmicus reactivation following laser in situ keratomileusis (lasik) for myopia. | 2002 | 11828912 |
| detection of varicella-zoster virus dna in throat swabs of patients with herpes zoster and on air purifier filters. | zoster patients are considered to be less contagious than those with varicella because their infectious lesions are localized. however, it is not known when the spread of varicella-zoster virus (vzv) from zoster patients begins, how long it continues, and how far the virus spreads from the zoster patients. twelve cases of hospitalized zoster patients were studied. the polymerase chain reaction (pcr) was used to detect vzv dna in samples taken from the surface of their eruptions, throats, and the ... | 2002 | 11857538 |
| opportunistic infections after renal transplantation. | opportunistic infection is a serious clinical complication in patients receiving immunosuppressive therapy after kidney transplantation. this article deals with some of the possible infectious agents that were recently encountered at our transplantation centre in düsseldorf, germany. opportunistic organsims such as human herpesviruses 6-8, polyomavirus, parvovirus b19, varicella zoster virus, nocardia and listeria monocytogenes are rare but severe complications that are presented in this overvie ... | 2002 | 11859257 |
| changes in age related seroprevalence of antibody to varicella zoster virus: impact on vaccine strategy. | to study changes in the seroprevalence of varicella zoster virus (vzv) antibody over the past 25 years with a view to determining the target age group for any future vaccination strategy. | 2002 | 11865016 |
| phosphorylation of varicella-zoster virus ie63 protein by casein kinases influences its cellular localization and gene regulation activity. | during the early phase of varicella-zoster virus (vzv) infection, immediate early protein 63 (ie63) is expressed rapidly and abundantly in the nucleus, while during latency, this protein is confined mostly to the cytoplasm. because phosphorylation is known to regulate many cellular events, we investigated the importance of this modification on the cellular localization of ie63 and on its regulatory properties. we demonstrate here that cellular casein kinases i and ii are implicated in the in vit ... | 2002 | 11912195 |
| varicella vaccination in children with steroid-sensitive nephrotic syndrome. | we have studied serological and clinical response to live, attenuated varicella zoster virus (vzv) vaccine (varilrix, smithkline beecham) in 20 patients with steroid-sensitive nephrotic syndrome (ssns) in remission and 22 normal controls who had no history of varicella and no detectable antibody to vzv. nephrotic patients included 15 boys and 5 girls, with a mean age of 4.7 years (range 2-11.4 years). the controls were healthy age-matched children (13 girls and 9 boys). seventeen patients with s ... | 2002 | 11956856 |
| 6-[2-(phosphonomethoxy)alkoxy]pyrimidines with antiviral activity. | 6-hydroxypyrimidines substituted at positions 2 and 4 by hydrogen, methyl, amino, cyclopropylamino, dimethylamino, methylsulfanyl, or hydroxyl group afford by the reaction with diisopropyl 2-(chloroethoxy)methylphosphonate in the presence of nah, cs(2)co(3), or dbu a mixture of n(1)- and o(6)-[2-(diisopropylphosphorylmethoxy)ethyl] isomers which were converted to the free phosphonic acids by treatment with bromotrimethylsilane followed by hydrolysis. analogously, 2,4-diamino-6-hydroxypyrimidine ... | 2002 | 11960502 |
| lack of susceptibility of bicyclic nucleoside analogs, highly potent inhibitors of varicella-zoster virus, to the catabolic action of thymidine phosphorylase and dihydropyrimidine dehydrogenase. | the susceptibility of the bicyclic nucleoside analogs (bcnas), highly potent and selective inhibitors of varicella-zoster virus (vzv), to the enzymes involved in nucleoside/nucleobase catabolism has been investigated in comparison with the established anti-vzv agent (e)-5-(2-bromovinyl)-2'-deoxyuridine [bvdu; brivudine (zostex)]. whereas human and bacterial thymidine phosphorylases (tpases) efficiently converted bvdu to its antivirally inactive free base (e)-5-(2-bromovinyl)uracil (bvu), bcnas s ... | 2002 | 11961132 |
| no evidence of parvovirus b19, chlamydia pneumoniae or human herpes virus infection in temporal artery biopsies in patients with giant cell arteritis. | recent studies have suggested that infective agents may be involved in the pathogenesis of giant cell arteritis (gca), in particular chlamydia pneumoniae and parvovirus b19. we investigated temporal arteries from patients with gca for these infections as well as human herpes viruses using the polymerase chain reaction (pcr). | 2002 | 11961176 |
| utility of a multiplex pcr assay for detecting herpesvirus dna in clinical samples. | a multiplex pcr was designed to amplify herpes simplex virus types 1 and 2, cytomegalovirus, and varicella-zoster virus dna present in a diverse range of clinical material. the susceptibility of these viruses to in vivo inhibition by at least one antiviral drug was an important consideration in their inclusion in the multiplex detection system. an aliquot of equine herpesvirus was introduced into each specimen prior to extraction and served as an indicator of potential inhibitors of the pcr and ... | 2002 | 11980951 |
| oesophagobronchial fistula caused by varicella zoster virus in a patient with aids: a unique case. | human herpesvirus oesophagitis in human immunodeficiency virus positive patients is caused by cytomegalovirus and herpes simplex virus; no cases of oesophagitis and oesophagobrochial fistula as a result of varicella zoster virus (vzv) have been reported to date. this report describes the case of a patient with a 2-3 mm deep oesophageal ulcer whose viral culture was positive for vzv. the patient was treated with acyclovir with resolution of the symptomatology. after the end of the induction treat ... | 2002 | 11986352 |
| varicella pneumonia: another 'steroid responsive' pneumonia? | varicella-zoster virus (vzv) pneumonitis remains an often-fatal complication of vzv infection. antiviral agents and supportive care are widely accepted therapies. cautious use of corticosteroids in life-threatening vzv pneumonitis may be justified. appropriate patient selection factors are as yet unidentified and the decision to commence corticosteroid therapy in this setting is clinical. | 2002 | 12017381 |
| sugar-modified conjugated diene analogues of adenosine and uridine: synthesis, interaction with s-adenosyl-l-homocysteine hydrolase, and antiviral and cytostatic effects. | moffatt oxidation of 2',3'-o-isopropylideneuridine (1a) and treatment of the crude 5'-aldehyde with formylmethylene-stabilized wittig reagent gave the vinylogously extended 7'-aldehyde2a. condensation of 2a with ethoxycarbonyl- or dibromomethylene phosphorane reagents gave the conjugated dienes 6a and 4a, respectively. deacetonization gave diene ester 7a [5'(e),7'(e); with s-trans conformation] and dibromodiene 5a [5'(e)], respectively. analogously, 2',3'-o-isopropylideneadenosine (1b) was witti ... | 2002 | 12036374 |
| guillain-barré syndrome after varicella zoster virus infections. a case report. | the case of a 13 year-old patient affected by guillain-barré syndrome developed after varicella zoster virus infection is reported. cerebrospinal fluid examination and motor and sensory conduction velocity were consistent with gbs. antibodies against gangliosides gm1 were present; it is likely that some of these may play an important role in the pathogenesis of syndrome after varicella infection. the therapy was carried out with increasing high-doses of immunoglobulins, with full clinical recove ... | 2002 | 12070486 |
| mononucleosis syndrome and acute monocytic leukemia. | the association of infectious mononucleosis and an immunocompromised host such as occurs in acute leukemia is reported. the most common cause of infectious mononucleosis is epstein-barr virus (ebv) and cytomegalovirus (cmv). patients with mononucleosis syndrome caused by other agents are rare. we report a case of acute monocytic leukemia (amol) who developed varicella zoster virus (vzv) mononucleosis syndrome in the bone marrow recovery phase after myelosuppression due to high-dose cytarabine. m ... | 2002 | 12071940 |
| laboratory diagnosis of central nervous system infections caused by herpesviruses. | herpesviruses may be associated with various types of central nervous system (cns) infections. herpes simplex encephalitis (hse) has to be considered one of the most severe diseases. as effective antiviral drugs are available, rapid and reliable diagnosis has become important. | 2002 | 12091081 |
| herpes consensus pcr test: a useful diagnostic approach to the screening of viral diseases of the central nervous system. | infections of the central nervous system (cns) are a difficult diagnostic problem for both clinicians and microbiologists. various clinical signs, such as encephalitis, myelitis, meningitis, may be associated with herpesviruses. the use of multiplex 'herpes consensus' polymerase chain reaction (hc-pcr) in association with nested pcr (npcr), in addition to classical techniques, made it possible to optimise the management of cerebrospinal fluid (csf) and serum samples from patients affected by the ... | 2002 | 12091084 |
| diagnosis of herpesvirus infections of the central nervous system. | human herpesviruses may cause infections of the central nervous system (cns). the early diagnosis of herpesvirus-associated neurological diseases is of high importance. | 2002 | 12091085 |
| use of an inactivated varicella vaccine in recipients of hematopoietic-cell transplants. | the reactivation of varicella-zoster virus from latency causes zoster and is common among recipients of hematopoietic-cell transplants. | 2002 | 12097537 |
| the effect of vaccination on the epidemiology of varicella zoster virus. | varicella zoster virus (vzv) causes chickenpox (varicella) on primary exposure and can reactivate later in life to cause shingles (zoster). as primary infection is more serious in adults than children, and exposure to the virus might boost the immune response to both chickenpox and shingles, there are two main concerns regarding infant vzv vaccination: that it could lead to an increase in adult disease; and/or that it could lead to a temporary increase in the incidence of shingles. this paper re ... | 2002 | 12099726 |
| posttransplant viral syndromes in pediatric patients: a review. | the success of pediatric solid organ transplantation has been largely due to advancements in surgical techniques, technology, and preoperative and postoperative care. potent immunosuppression continues to reduce the incidence and severity of rejection, and improve long-term survival. however, there is growing awareness of the role immunosuppression plays in contributing to the incidence of cytomegalovirus, epstein-barr virus, and epstein-barr virus-associated posttransplant lymphoproliferative d ... | 2002 | 12123172 |
| glycoprotein i of varicella-zoster virus is required for viral replication in skin and t cells. | varicella-zoster virus (vzv) glycoprotein i (gi) is dispensable in cell culture; the scidhu model of vzv pathogenesis was used to determine whether gi is necessary in vivo. the parental and repaired viruses grew in human skin and thymus/liver implants, but the gi deletion mutant was not infectious. thus, gi is essential for vzv infectivity in skin and t cells. | 2002 | 12134050 |
| outbreaks of disease suspected of being due to human monkeypox virus infection in the democratic republic of congo in 2001. | seven outbreaks of disease characterized by a pustular rash and suspected to have been caused by human monkeypox virus were investigated. the outbreaks occurred between february and august 2001 in the province of equateur in the democratic republic of congo. the outbreaks involved a total of 31 persons and caused five deaths. specimens from 14 patients were available and were analyzed by electron microscopy, virus isolation, and pcr assays specific for monkeypox virus and varicella-zoster virus. ... | 2002 | 12149352 |
| frequency of congenital varicella syndrome in a prospective cohort of 347 pregnant women. | to estimate the rate of congenital varicella zoster virus syndrome in neonates born to women developing varicella zoster virus infections during pregnancy. | 2002 | 12151147 |
| naturally acquired simian varicella virus infection in african green monkeys. | simian varicella virus (svv) infection of primates shares clinical, pathological, immunological, and virological features with varicella-zoster virus infection of humans. natural varicella infection was simulated by exposing four svv-seronegative monkeys to monkeys inoculated intratracheally with svv, in which viral dna and rna persist in multiple tissues for more than 1 year (t. m. white, r. mahalingam, v. traina-dorge, and d. h. gilden, j. neurovirol. 8:191-205, 2002). the four naturally expos ... | 2002 | 12163574 |
| detection of varicella zoster virus dna in tear fluid and saliva of patients with ramsay hunt syndrome. | to clarify the dynamics of the reactivation of the varicella zoster virus in ramsay hunt syndrome. | 2002 | 12170168 |
| herpes zoster by reactivated vaccine varicella zoster virus in a healthy child. | varicella can be prevented by vaccination using the live-attenuated oka vaccine strain of varicella zoster virus (vzv). only mild breakthrough disease has been reported in seronegative vaccinees when exposed to the wild-type virus. the latent varicella vaccine virus has rarely caused herpes zoster in childhood and adolescence. we report a healthy 2-year-old girl who developed an impressive herpes zoster infection 16 months after vaccination, localised in three cervical dermatoma. as causative vi ... | 2002 | 12172829 |
| varlirix (glaxosmithkline). | glaxosmithkline (formerly smithkline beecham) has developed and launched varilrix, a preparation of live, attenuated oka-strain varicella zoster virus, for immunization against varicella zoster infections [455138]. by the end of 1998, varilrix was available in a few european countries and in india [284490], [455138]. by 2001, the vaccine was also available in brazil and hong kong [396267]. | 2002 | 12186278 |
| neurovisual manifestations of herpesviruses. | 2002 | 12189613 | |
| the role of solar ultraviolet irradiation in zoster. | ultraviolet radiation (uvr) suppresses many aspects of cell-mediated immunity but it is uncertain whether solar uv exposure alters resistance to human infectious diseases. varicella-zoster virus (vzv) causes varicella (chickenpox) and can reactivate from latency to cause zoster (shingles). the monthly incidence of chickenpox and zoster in a defined polish population over 2 years was recorded and ground level solar uv was measured daily. there was a significant seasonality of uvr. evidence of sea ... | 2002 | 12558343 |
| [clinical aspects and diagnosis of epstein-barr virus infections]. | 2002 | 14750257 | |
| prevention and treatment of vzv infections in patients with hiv. | varicella zoster virus (vzv) infections in human immunodeficiency virus (hiv)-infected patients are known to have a different disease spectrum from that seen in other types of patients. varicella in children with hiv infection is likely to be more serious than in otherwise healthy children and routine antiviral therapy is recommended. there is evidence that the development of varicella in hiv-infected children is not associated with progression to aids, suggesting that it may be safe to immunize ... | 2001 | 11867015 |
| [post-zoster granuloma with detection of varicella zoster virus dna in the granulomas]. | granulomatous skin changes following herpes zoster are uncommon and their pathogenesis is unclear. we demonstrated varicella-zoster virus in the granuloma tissue of an immunocompromised patient with postherpetic granulomas and use this finding as basis for discussing the pathogenesis of these lesions. | 2001 | 11910864 |
| prolonged herpes zoster in a patient infected with the human immunodeficiency virus. | in 1983, varicella zoster virus (vzv) disease was first recognized in the context of infection with the human immunodeficiency virus (hiv). since that time, there have been many reports discussing the occurrence and clinical manifestations of hepes zoster in hiv-infected patients. we describe the development of prolonged herpes zoster in a patient with acquired immunodeficiency syndrome (aids) over the course of 104 days. viral isolates at the three different clinical stages of the skin lesions ... | 2001 | 11804069 |
| varicella-zoster virus infections of the nervous system: clinical and pathologic correlates. | diseases that present with protean manifestations are the diseases most likely to pose diagnostic challenges for both clinicians and pathologists. among the most diverse disorders caused by a single known toxic, metabolic, neoplastic, or infectious agent are the central and peripheral nervous system complications of varicella-zoster virus (vzv). | 2001 | 11371229 |
| induction of human immunodeficiency virus 1 replication by human herpesvirus 8. | human immunodeficiency virus 1 (hiv-1)-infected individuals are commonly infected with herpesviruses, including cytomegalovirus, herpes simplex virus, varicella-zoster virus, and human herpesvirus 8 (hhv-8, also known as kaposi sarcoma-associated herpesvirus [kshv]). previous studies have demonstrated that coinfection with herpesviruses can modulate hiv-1 replication. this can occur either through direct interaction between the 2 viruses or through secondary effects resulting from the release of ... | 2001 | 11371231 |
| extensive and long-term ex vivo production of dendritic cells from cd34 positive umbilical cord blood or bone marrow cells by novel culture system using mouse stroma. | we previously developed a system using murine strome (hess-5), which could expand umbilical cord blood (ucb) stem and progenitor cells, especially cd34+/38- cells, in the presence of human recombinant cytokines. in this study, the ability of expanded ucb- or bone marrow (bm)-cd34+ cells to differentiate into dendritic cells (dcs) was examined. dcs could be induced either from short or long term cultured cd34+ cells after switching the cytokines from flk-2/flt-3 ligand, stem cell factor (scf), th ... | 2001 | 11384668 |
| immunity and prevention of herpes zoster. proceedings of an international conference. osaka, japan, march 8-10, 1999. | 2001 | 11386248 | |
| design, synthesis and enzymatic activity of highly selective human mitochondrial thymidine kinase inhibitors. | highly selective arabinofuranosyl nucleosides, which inhibit the mitochondrial thymidine kinase (tk-2) without affecting the closely related herpes simplex virus type 1 thymidine kinase (hsv-1 tk), varicella-zoster virus thymidine kinase (vzv-tk), cytosolic thymidine kinase (tk-1) or the multifunctional drosophila melanogaster deoxyribonucleoside kinase (dm-dnk), have been obtained. sar studies indicate a close relation between the length of the substituent at the 2' position of the arabinofuran ... | 2001 | 11392548 |
| [analysis of the aqueous humor in keratoplasty patients with keratitis. initial results]. | herpetic keratitis is a common indication for corneal transplantation. in this patient group especially, there is a relatively high risk of graft failure, partly because of viral recurrence. it can be difficult to clinically distinguish stromal herpetic recurrence from early endothelial allograft rejection. also a perioperative observation of viral activity seems advisable because of therapeutic consequences. for these reasons we use aqueous humor analysis in certain corneal transplant patients ... | 2001 | 11402827 |
| radioimmunotherapy with iodine-131 tositumomab in patients with low-grade non-hodgkin's b-cell lymphoma does not induce loss of acquired humoral immunity against common antigens. | thirty-one previously untreated patients with follicular low-grade b-cell non-hodgkin's lymphoma expressing the cd20 antigen were treated with iodine-131 tositumomab therapy between 1996 and 1998. the therapy led to a temporary depletion of peripheral blood b-lymphocytes. recovery of b-cells occurred in most cases by 3 to 6 months and in all patients by 12 months posttherapy. a temporary decline in t-cell subpopulations, but no reduction in serum immunoglobulin levels, could be observed. elisa t ... | 2001 | 11414744 |
| zoster in patients infected with hiv: a review. | varicella-zoster virus (vzv), a member of the human herpesvirus family, causes childhood chickenpox (varicella), becomes latent in sensory ganglia, and reactivates years later in immunocompromised and elderly persons to produce shingles (herpes zoster). early in the aids epidemic, zoster was noted in adults and children infected with hiv. severe and debilitating zoster-associated dermatological, ophthalmic, and neurological complications may occur in patients infected with hiv. antiviral therapy ... | 2001 | 11417752 |
| nucleotide sequence analysis of varicella-zoster virus glycoprotein e epitope coding regions. | varicella-zoster virus (vzv) glycoprotein e [ge] contains 623 amino acid residues. fifty percent of the ge gene, codons 39 to 344 that encompasses two epitope coding regions e1 and c1, was sequenced and analyzed for variation among the 30 vzv isolates. a total of eleven isolates showed variance when compared with dumas vzv strain sequence through base substitutions, with two isolates showing an amino acid change of tryptophan to arginine outside the coding regions of the epitopes e1 and c1 that ... | 2001 | 11427254 |
| progressive outer retinal necrosis syndrome in a lymphoma patient with good visual outcome. | to report an hiv-negative lymphoma patient who developed progressive outer retinal necrosis syndrome and who had a good visual outcome after treatment with two-drug antiviral therapy and intravenous immunoglobulin. | 2001 | 11438070 |
| varicella-zoster virus meningitis and cerebrospinal fluid hiv rna. | 2001 | 11440237 | |
| screening of patients with complex regional pain syndrome for antecedent infections. | this study was designed to investigate whether complex regional pain syndrome type i (crps i) could be linked to any previous infection. | 2001 | 11444711 |
| molecular diagnosis of visceral herpes zoster. | patients with disseminated herpes zoster may present with severe abdominal pain that results from visceral involvement of varicella-zoster-virus infection. in the absence of cutaneous eruptions of herpes zoster, visceral herpes zoster is extremely difficult to diagnose. this diagnostic difficulty has the potential to cause devastating delays in treatment. we report a case series of four patients with visceral herpes zoster in whom large concentrations of dna from varicella zoster virus were dete ... | 2001 | 11445106 |
| evidence for antigen-specific immune deviation in patients with acute retinal necrosis. | because experimental acute retinal necrosis (arn) induced by herpes simplex virus in mice develops only if mice fail to acquire virus-specific delayed hypersensitivity (dh), although they produce antiviral antibodies (ie, anterior chamber-associated immune deviation), we sought to determine whether a similar inverse correlation exists for patients with varicella-zoster virus (vzv)-induced arn. | 2001 | 11448326 |
| the seroepidemiology of varicella in italy. | we conducted a seroepidemiological study to evaluate the potential impact of mass varicella vaccination on the transmission of varicella-zoster virus (vzv) in italy, where vaccination is not mandatory. we tested 3179 serum samples, collected from september 1996 to october 1997, for specific anti-vzv antibodies using a commercially available elisa. the results confirmed that varicella typically involves children (82.1% seroprevalence among 10- to 14-year-olds) and that the mean age of acquiring t ... | 2001 | 11467800 |
| disseminated vaccine strain varicella as the acquired immunodeficiency syndrome-defining illness in a previously undiagnosed child. | the food and drug administration licensed a live-virus varicella vaccine (varivax; merck & co inc, west point, pa) in march 1995. prelicensure adverse events were minimal; however, since licensure and increased vaccine use, rare previously undetected risks have arisen. presented here is the clinical course of a previously undiagnosed, human immunodeficiency virus-infected boy who developed dissemination of the vaccine strain of varicella zoster after immunization. chickenpox, human immunodeficie ... | 2001 | 11483849 |
| varicella-zoster virus: molecular virology and virus-host interactions. | cosmid-based mutagenesis and methods to examine varicella-zoster virus (vzv) tropism for differentiated human cells in vivo provide new information about molecular mechanisms of vzv infection. how specific vzv gene products contribute to viral replication has been further defined, and effects of vzv on expression of cellular genes have been demonstrated. | 2001 | 11495809 |
| noncutaneous varicella-zoster virus (vzv) infection with fatal liver failure in a child with acute lymphoblastic leukemia (all). | 2001 | 11496356 | |
| [varicella zoster virus infection after bone marrow transplant. unusual presentation and importance of prevention]. | leukemeia and lymphoproliferative disease are associated with a high risk of varicela-zoster virus (vzv) infection. although infrequent, visceral involvement can be fatal. we report two cases of patients presenting severe vzv infection after bone marrow transplantation. | 2001 | 11505833 |
| varicella-zoster virus orf47 protein serine kinase: characterization of a cloned, biologically active phosphotransferase and two viral substrates, orf62 and orf63. | varicella-zoster virus (vzv) codes for a protein serine kinase called orf47; the herpes simplex virus (hsv) homolog is ul13. no recombinant alphaherpesvirus serine kinase has been biologically active in vitro. we discovered that preservation of the intrinsic kinase activity of recombinant vzv orf47 required unusually stringent in vitro conditions, including physiological concentrations of polyamines. in this assay, orf47 phosphorylated two vzv regulatory proteins: the orf62 protein (homolog of h ... | 2001 | 11507231 |
| lightcycler multiplex pcr for the laboratory diagnosis of common viral infections of the central nervous system. | a conventional multiplex pcr assay that detects herpes simplex virus type 1 (hsv-1), hsv-2, varicella-zoster virus, and enteroviruses for the diagnosis of central nervous system infections was modified to be performed using the lightcycler system. the sensitivity of detection of each of the viruses using the lightcycler assay was compared to that of the conventional assay using external quality assessment material. the assays had equivalent sensitivities, but the lightcycler assay was more rapid ... | 2001 | 11526128 |