Publications

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effect of prophage w on the propagation of bacteriophages t2 and t4.studies have been undertaken to determine whether the temperate phage omega present in escherichia coli strain w is responsible for the inability of this strain to act as a host for t2 and t4. e. coli ws, cured of phage omega, was sensitive to t2 and t4. lysogenation of e. coli c and ws with phage omega resulted in loss of ability to plate t2 and t4. however, e. coli k-12 lysogens still served as hosts for the t -even phage. two of three ws lysogens studied resembled strain w at the biochemical ...19685701827
a map of distances along the dna molecule of phage t4. 19685702346
the effect of helper phages and--or multiplicity of infection on the repair of ultraviolet damages in t4. 19685722186
inactivation of phage t4 by ethylmethane sulfonate. 19685722213
inactivating and mutagenic effects of 1-methyl-3-nitro-1-nitrosoguanidine on intracellular bacteriophage.1-methyl-3-nitro-1-nitrosoguanidine (ng) was able to inactivate and mutate adsorbed but not free coliphage t2. coliphage t4 was as sensitive to ng as t2. when treatment was delayed for 5 min or longer after adsorption of t2, the phage became increasingly refractory to ng inactivation.19685725321
t4 bacteriophage mutants suppressible by a missense suppressor which inserts glycine in place of arginine for the codon aga.phage mutants of t4 have been isolated which can multiply only on escherichia coli strains which contain a missense suppressor which is known to cause the substitution of glycine for arginine in response to the aga codon. mutations producing the suppressible phenotype were mapped and shown to occur in six different phage cistrons. two of the cistrons were concerned with deoxyribonucleic acid synthesis, two were concerned with phage structural components, and two were concerned with functions req ...19685725322
an in vitro transversion by a mutationally altered t4-induced dna polymerase. 19684939629
chain growth rate of messenger rna in escherichia coli infected with bacteriophage t4. 19684938556
identification of the transcribing dna strand for the rii and endolysin genes of coliphage t4. 19684938565
complete primary structure of phage lysozyme from escherichia coli t4. 19684939036
evidence for a magnesium pump induced by bacteriophage t4. 19684972798
acridine binding by escherichia coli: ph dependency and strain differences.acridine dye binding by cells of escherichia coli has been characterized in terms of a number of parameters. there is a temperature-dependent, readily reversible binding of acriflavine which occurs to a greater extent with acridine-sensitive mutants of e. coli k-12 than with wild-type e. coli b or k-12. there is an essentially irreversible internal binding of acriflavine which occurs when the cellular permeability barriers are destroyed or altered by heat-treatment, elevated ph, treatment with t ...19684867737
location of glucosyl transferase genes on the genetic map of phage t4. 19684867911
assembly of the tail of bacteriophage t4. 19684868421
some steps in the assembly of bacteriophage t4. 19684868422
exhaustive hybridization and its application to an analysis of the ribonucleic acid synthesized in t4-infected cells. 19684868543
modified dna-dependent rna polymerase from e. coli infected with bacteriophage t4. 19684869542
specificity of polyribosomes in the synthesis of t4 bacteriophage head protein. 19684870334
fractionation of the complementary strands of coliphage t4 dna based on the asymmetric distribution of the poly u and poly u,g binding sites. 19684870391
studies on the morphopoiesis of the head of phage t-even. v. the components of the t4 capsid and of other, capsid-related structures. 19684870477
lysis of t4-infected bacteria in the absence of lysozyme. 19684871001
failure of incomplete t4 genomes to replicate under conditions of single infection. 19684871002
inhibition of gamma-ray-induced degradation of e. coli bs-1 dna by infection with t1, t2 and t4 bacteriophage. 19684871998
evidence for long dna strands in the replicating pool after t4 infection. 19684873341
genetic transformation of the bacteriophage t4. ii. biological activity of dna fragments. 19684873555
genetic transformation of the bacteriophage t4. i. an outline and some properties of the phage transformation system. 19684873560
nonsense suppression in a multiauxotrophic derivative of escherichia coli 15t-: identification and consequences of an amber triplet in the deoxyribomutase gene.previously, arginine revertants of escherichia coli wwu, a derivative of e. coli 15t(-), have been subdivided by two independent methods: (i) the streak morphology on nutrient agar, and (ii) the pattern of phage growth using amber and ochre mutants of bacteriophage t4. in the first assay, revertants were subdivided into two classes according to the appearance of streaks after incubation on nutrient agar, a thick, even line of growth defining normal revertants and a thin, irregular line defining ...19684874302
metabolism of deoxythymidine 3'-mono- and diphosphate in normal and t4 bacteriophage-infected escherichia coli. 19684875414
studies of dna replication in vivo. 3. accumulation of a single-stranded isolation product of dna replication by conditional mutant strains of t4. 19684875804
influence of t4 on the formation of rna phage-specific polyribosomes and polymerase. 19684877003
role of polynucleotide ligase in t4 dna replication. 19684877007
coding by t4 phage dna of soluble rna containing pseudouridylic acid. 19684877271
[t4 phage-induced lysozyme dependent e. coli treated with mytomycin c]. 19684878093
[correlation between filament formation of e. coli and plaque-type changes of bacteriophage t4]. 19684878095
enzymatic breakage and joining of deoxyribonucleic acid. vi. further purification and properties of polynucleotide ligase from escherichia coli infected with bacteriophage t4. 19684879167
control of phage and host ribonucleic acid synthesis in phage t4 infected escherichia coli. 19684879187
phospholipid synthesis in escherichia coli infected with t4 bacteriophages.after infection of escherichia coli with t4 phage, phospholipid synthesis continued but at a reduced rate. the same phospholipid components were synthesized as in uninfected cells; however, the relative rates of (32)p(i) incorporation into phosphatidylglycerol (pg) and phosphatidylethanolamine (pe) were altered. this alteration was most pronounced during the first 10 min after infection. under these conditions, the isotope incorporated into pg equaled or exceeded that found in pg from uninfected ...19684880428
effect of t4 infection on messenger rna synthesis in escherichia coli. 19684880561
transfer rna coded by the t4 bacteriophage genome. 19684880604
biochemistry of deoxyribonucleic acid-defective amber mutant of bacteriophage t4. i. ribonucleic acid metabolism. 19684880757
the role of phage lysozyme in the life cycle of phage t4. 19684881032
a structural gene for bacteriophage t4-induced deoxycytidine triphosphate-deoxyuridine triphosphage nucleotidohydrolase. 19684881036
mode of action of colicins of types e1, e2, e3, and k.the effect of colicins on deoxyribonucleic acid and protein synthesis, and also their effect on the ability of t4 phage to replicate in escherichia coli k-12, were studied. colicins of type k inhibited deoxyribonucleic acid synthesis, protein synthesis, and phage growth. among colicins of type e, there was an absolute correlation between mode of action and subdivision into types e(1), e(2), and e(3).19684882019
[polarity mutation of t4 phage]. 19684882392
distribution of growing points in dna of bacteriophage t4. 19684882615
inhibition of host protein synthesis during infection of escherichia coli by bacteriophage t4. i. continued synthesis of host ribonucleic acid.the ribonucleic acid (rna) synthesized at specified intervals during infection of escherichia coli k-12 by bacteriophage t4 was hybridized to denatured e. coli or t4 deoxyribonucleic acids (dna). the reactions were performed under conditions that maximized the yield and at rna/dna inputs such that excess dna sites were available for all rna species. most of the rna synthesized at any time during the first 3 min of infection was host-specific. the fraction declined rapidly as infection progressed ...19684883015
further studies on the requirement for formyl residues in the synthesis of bacteriophage t4 proteins. 19684883326
studies on the lysozyme from the bacteriophage t4 ejd7ejd4, carrying two frame shift mutations. 19684883531
amino acid control of rna synthesis in t4-infected escherichia coli. 19684884582
recovery of uv-inactivated e. coli cells by the v-gene action of phage t4. 19684884675
enzymatic breakage and joining of deoxyribonucleic acid. iv. dna synthesis in e. coli infected with ligase-negative mutants of phage t4. 19684884682
intermediates in t4 dna replication in a t4 ligase deficient strain. 19684891959
studies on the joining of dna by polynucleotide ligase of phage t4. 19684891960
repair and recombination in phage t4. i. genes affecting recombination. 19684891972
repair and recombination in phage t4. ii. genes affecting uv sensitivity. 19684891973
the function of t4 dna polymerase. 19684891974
evidence for a possible direct role of dcmp hydroxymethylase in t4 phage dna synthesis. 19684891975
replication and recombination of dna fragments in bacteriophage t4. 19684891976
phage dna synthesis in bacteria infected with t4 light particles. 19684891977
dna polymerase and the cell membrane after t4 infection. 19684891988
initiation and propagation of growing points in the dna of phage t4. 19684891989
bacterial genetic factors controlling the suppression of t4 phage amber mutants. i. suppression patterns of a collection of e. coli strains. 19684890344
bacterial genetic factors controlling the suppression of t4 phage amber mutants. ii. suppression patterns among the segregants of bacterial crosses. 19684890345
molecular recombination in the ligase negative t4 amber mutant. 19684894254
enzymatic synthesis of deoxyribonucleic acid. xxv. purification and properties of deoxyribonucleic acid polymerase induced by infection with phage t4. 19684866523
host-controlled restriction of t-even bacteriophages: relation of endonuclease i and t-even-induced nucleases to restriction.restriction of nonglucosylated t2 phage (t(*)2) as a function of bacterial growth state was the same for endonuclease i-containing and endonuclease i-deficient strains of escherichia coli b. furthermore, e. coli strains with various levels of restriction for t2 had comparable endonuclease i activities. it was also found that a t4 mutant temperature-sensitive for gene 46 and 47 functions was fully restricted at 42 c. it therefore appears that neither endonuclease i nor the phage-induced nucleases ...19684911845
bacteriophage-induced inhibition of host functions. i. degradation of escherichia coli deoxyribonucleic acid after t4 infection.the kinetics of degradation of bacterial deoxyribonucleic acid (dna) after infection of escherichia coli with t4d, ultraviolet-irradiated t4d, and two amber mutants, n122 and n94, was studied by zone sedimentation through linear glycerol gradients. within 5 min after infection with any of the bacteriophages, breakdown of host genome was evident. the first product was a high-molecular-weight material (50s to 70s) and further degradation appeared to occur in discrete steps. rapid and extensive bre ...19684911847
reversible repression of early enzyme synthesis in bacteriophage t4-infected escherichia coli.a mutant of escherichia coli b, defective in its accumulation of k(+), was found to synthesize protein at a rate proportional to the level of this cation in the growth medium. when bacteriophage t4-infected cells were incubated in growth medium containing 1 mm k(+), phage deoxyribonucleic acid (dna) was synthesized at a rate 25% that of normal, and phage protein was synthesized at a rate of 50% of normal. deoxycytidine pyrophosphatase, a phage-directed early enzyme, shut off at a level of 55% th ...19684911851
control of lysis of t4-infected escherichia coli.the lysis of escherichia coli b/5 infected with t4dr48 could be delayed by addition of 9-aminoacridine (9aa). infected cells showed an early period of maximal response followed by a decline in sensitivity. the ultimate rate of lysis was also affected by the dye. deoxyribonucleic acid (dna), protein, and lysozyme synthesis began at the normal time in complexes inhibited by 9aa addition. the rates of synthesis of these macromolecules were lower in the presence of the dye, with dna and lysozyme syn ...19684911852
purification of bacteriophage t4 lysozyme. 19684865643
non-repeating nucleotide sequences in the genome of bacteriophage t4. 19684866115
polyriboadenylate polymerase and its inhibition in t4-infected escherichia coli and shigella dysenteriae. 19684866301
transcription during bacteriophage t4 development: synthesis and relative stability of early and late rna. 19684866329
amino acid acceptor activity of bacteriophage t4 transfer rna. 196811946263
the luria-latarjet effect studied by t4-lysozyme production.the replication of bacteriophage t4 in escherichia coli is sensitive to ultraviolet light (uv). the classical plaque assay shows a considerable increase in uv resistance starting at about 5 minutes after the bacteria are infected. production of phage lysozyme starts about 10 minutes after infection and is sensitive to irradiation. its uv resistance increases at about 4 minutes. the appearance of resistance, measured by both the plaque assay and lysozyme production, is inhibited by p-fluorophenyl ...196818614109
cellular heterogeneity in the production of an anti-hapten antibody.single lymph node cells from rats immunized with a conjugate of 3-iodo-4-hydroxy-5-nitrophenyl acetic acid chloride (nip) and chicken globulin were tested against either nip or nnp conjugated with bacteriophage. nnp is related to nip but has a nitro group instead of iodine. the conjugated phages were still infective but easily inactivated by anti-hapten sera at a serum concentration of 10(-7). phages carrying a related hapten were less sensitive to antibody than phages conjugated with the immuno ...19674165500
structure of normal and contracted tail sheaths of t4 bacteriophage. 19674167417
evidence derived from hno2 mutagenesis that only one of the two dna strands injected by phage t4 transmits hereditary information to the progeny. 19674228866
amber mutants of bacteriophage t4 defective in deoxycytidine diphosphatase and deoxycytidine triphosphatase. on the role of 5-hydroxymethylcytosine in bacteriophage deoxyribonucleic acid. 19674319673
on the requirement for formyl residues in the synthesis of bacteriophage t4 proteins. 19674866444
low-molecular-weight t4 phage-specific rna. 19674860429
mutants of bacteriophage t4 unable to induce dihydrofolate reductase activity. 19674860754
studies on the mechanism of bacteriophage t4 interference with host metabolism. 19674860987
presence of t4 "early" messenger rna on polysomes late in infection. 19674861178
detection of a peptide determined by the rii b cistron of phage t4. 19674861309
interference of bacteriophage t4 in the reproduction of rna-phage m12. 19674861612
characterization of revertants of e. coli wu36-10 and wp2 using amber mutants and an ochre mutant of bacteriphage t4. 19674862436
incorporation of uracil-14c into nucleic acids in escherichia coli infected with bacteriophage t4 and t4 amber mutants. 19674863170
the mechanism of lysis in phage t4-infected cells. 19674863172
[study of the genetic code with t4 phage lysozyme]. 19674863362
effect of acridine orange on survival and capacity of escherichia coli b for t3 and t4 phage during anoxia. 19674863401
the action of 5-azacytidine on bacteria infected with bacteriophage t4. 19674863910
methylation of rna in bacteriophage t4 infected escherichia coli. 19674864798
a frame-shift mutation resulting in the deletion of two base pairs in the lysozyme gene of bacteriophage t4. 19674865145
transformation in phage t4: minmal recognition length between donor and recipient dna. 19674865571
control of bacteriophage-induced enzyme synthesis in cells infected with a temperature-sensitive mutant.the timing of "early" and "late" protein synthesis in escherichia coli infected with t-even bacteriophage was studied with a temperature-sensitive phage mutant, t4 tsl13. this strain was completely unable to direct the synthesis of phage deoxyribonucleic acid (dna) at 44 c because it makes a deoxycytidylate hydroxymethylase which cannot act at that temperature. however, the mutant did multiply normally at 30 c. no detectable formation of the late protein, lysozyme, occurred at 44 c, in agreement ...19674918234
early intracellular events in the replication of t4 phage dna, iv. host-mediated single-stranded breaks and repair in ultraviolet-damaged t4 dna. 19674866987
the instability of t4 messenger rna. 19674964032
lysis inhibition in escherichia coli infected with bacteriophage t4.a technique of continuous filtration of t4-infected escherichia coli has been devised to study the phenomenon of lysis inhibition. studies using this technique revealed that the length of the lysis delay caused by superinfection can attain only certain discrete values, which for low average multiplicity of superinfection is thought to be a reflection of the actual number of superinfecting particles per cell. the time interval between primary and superinfection had little effect on the length of ...19674912240
growth of a dihydrofolate reductaseless mutant of bacteriophage t4.a mutant of bacteriophage t4 was isolated which was unable to induce virus-specific dihydrofolate reductase in infected cells. the mutant was able to form several other early enzymes of pyrimidine metabolism. growth of the mutant in a wild-type host, escherichia coli b, was compared with that of the parent strain, t4bo(1), and t4td8, a mutant which lacks the ability to induce thymidylate synthetase. growth studies were carried out in minimal medium, which gave higher growth rates and phage yield ...19674912241
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