Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| propionibacterium acnes as a possible pathogen of granuloma in patients with ocular sarcoidosis. | to detect propionibacterium acnes from intraocular granuloma in patients with ocular sarcoidosis. | 2017 | 28270483 |
| propionibacterium acnes infection of a metacarpophalangeal joint arthroplasty. | neglected and underestimated in the past, propionibacterium acnes is currently the most prevalent organism associated with deep prosthetic infections around the shoulder. surprisingly, it has never been reported as a cause of infection in the hand. here we report a case of a late presentation of a p. acnes infection in a metacarpophalangeal joint replacement, resulting in chronic low-grade pain with movement. the patient underwent a 2-stage revision, with initial removal of the prosthesis. posit ... | 2017 | 28259563 |
| evaluation of dental adhesive systems incorporating an antibacterial monomer eugenyl methacrylate (egma) for endodontic restorations. | the purpose of this study was to incorporate egma, an antibacterial monomer into two commercial dental adhesive systems for their application in endodontic restoration with the aim to disinfect the root canal space before curing and to inhibit bacterial growth on their surfaces after being cured. | 2017 | 28245928 |
| n-acetylcysteine inhibits growth, adhesion and biofilm formation of gram-positive skin pathogens. | n-acetylcysteine (nac) is a non-antibiotic drug with antimicrobial properties against biofilm phenotypes of gram-positive and gram-negative bacteria. our aim was to assess the effects of nac on the growth of gram-positive human skin and mucous membrane pathogens in the planktonic and biofilm phases. the minimum inhibitory concentrations (mics) of nac against enterococcus faecalis, corynebacterium ammoniagenes, mycobacterium smegmatis, propionibacterium acnes, staphylococcus aureus, s. epidermidi ... | 2017 | 28237766 |
| prospects of phage application in the treatment of acne caused by propionibacterium acnes. | propionibacterium acnes is associated with purulent skin infections, and it poses a global problem for both patients and doctors. acne vulgaris (acne) remains a problem due to its chronic character and difficulty of treatment, as well as its large impact on patients' quality of life. due to the chronic course of the disease, treatment is long lasting, and often ineffective. currently there are data regarding isolation of p. acnes phages, and there have been numerous studies on phage killing of p ... | 2017 | 28228751 |
| specific infectious organisms associated with poor outcomes in treatment for hip periprosthetic infection. | periprosthetic hip infection treatment remains a significant challenge for orthopedics. some studies have suggested that methicillin resistance and gram-negative organism type are associated with increased treatment failure. the aim of this research is to determine if specific organisms were associated with poor outcomes in treatment for hip periprosthetic infection. | 2017 | 28222919 |
| interaction of cutibacterium ( formerly propionibacterium) acnes with bone cells: a step toward understanding bone and joint infection development. | cutibacterium acnes (formerly propionibacterium acnes) is recognized as a pathogen in foreign-body infections (arthroplasty or spinal instrumentation). to date, the direct impact of c. acnes on bone cells has never been explored. the clade of 11 c. acnes clinical isolates was determined by mlst. human osteoblasts and osteoclasts were infected by live c. acnes. the whole genome sequence of six isolates of this collection was analyzed. cc36 c. acnes strains were significantly less internalized by ... | 2017 | 28218305 |
| propionibacterium acnes is developing gradual increase in resistance to oral tetracyclines. | propionibacterium acnes is an anaerobic bacterium that causes deep infection in organs and prosthetic joints, in addition to acne vulgaris. many tetracycline-resistant p. acnes strains have been isolated because oral tetracyclines are frequently used as an acne treatment against p. acnes. in this study, we found a novel tetracycline resistance mechanism in p. acnes. three doxycycline-resistant (mic: 16 µg ml-1) strains were isolated from 69 strains in acne patients in japan between 2010 and 2011 ... | 2017 | 28218057 |
| measuring acne using coproporphyrin iii, protoporphyrin ix, and lesion-specific inflammation: an exploratory study. | propionibacterium acnes: (p. acnes) produce porphyrins; however, fluorescence measurement of porphyrins from ultraviolet-a (uva) images has failed to establish a correlation. acne clinical research and imaging has ignored the spectral excitation-emission characteristics and the exact pattern of the porphyrins synthesized by p. acnes. in this exploratory study, for the first time, the possible relationships of coproporphyrin iii (cpiii) and protoporphyrin ix (ppix) fluorescence as well as acne le ... | 2017 | 28180934 |
| is infection the possible initiator of disc disease? an insight from proteomic analysis. | proteomic and 16s rdna analysis of disc tissues obtained in vivo. | 2017 | 28168343 |
| open-label, randomized, multicenter, phase iii study to evaluate the safety and efficacy of benzoyl peroxide gel in long-term use in patients with acne vulgaris: a secondary publication. | an open-label, randomized, multicenter study was conducted to evaluate the safety and efficacy of long-term use of 2.5% and 5% benzoyl peroxide (bpo) gels administrated once daily for 52 weeks to japanese patients with acne vulgaris. the efficacy of the study drugs was evaluated by counting inflammatory lesions and non-inflammatory lesions. safety was evaluated based on adverse events, local skin tolerability scores and laboratory test values. in total, 458 subjects were included in the efficacy ... | 2017 | 28150367 |
| acne and rosacea. | acne, one of the most common skin diseases, affects approximately 85% of the adolescent population, and occurs most prominently at skin sites with a high density of sebaceous glands such as the face, back, and chest. although often considered a disease of teenagers, acne is occurring at an increasingly early age. rosacea is a chronic facial inflammatory dermatosis characterized by flushing (or transient facial erythema), persistent central facial erythema, inflammatory papules/pustules, and tela ... | 2017 | 28150107 |
| high throughput 16srrna gene sequencing reveals the correlation between propionibacterium acnes and sarcoidosis. | this study aims to use high throughput 16srrna gene sequencing to examine the bacterial profile of lymph node biopsy samples of patients with sarcoidosis and to further verify the association between propionibacterium acnes (p. acnes) and sarcoidosis. | 2017 | 28143482 |
| draft genome sequence of an erythromycin-resistant propionibacterium acnes isolate recovered from folliculitis of the scalp. | propionibacterium acnes is now well-known and recognized for its implication in the pathogenesis of acne vulgaris. here, we report the draft genome sequence of an erythromycin-resistant p. acnes strain isolated from a case of folliculitis of the scalp belonging to phylotype ia1 and sequence type 18 (st18). | 2017 | 28126936 |
| a multifactorial comparison of ternary combinations of essential oils in topical preparations to current antibiotic prescription therapies for the control of acne vulgaris-associated bacteria. | acne vulgaris, a chronic condition associated with overgrowth of propionibacterium acnes and staphylococcus epidermidis, is commonly treated with antibiotics. however, the emergence of antibiotic resistance has resulted in a need for alternative therapies. the aim of this study is to develop a topical preparation incorporating essential oils (eos) for use against acne-associated bacteria and assess its efficacy against prescription therapies dalacin t and stiemycin. antimicrobial screening of ro ... | 2017 | 28124400 |
| topical delivery of roxithromycin solid-state forms entrapped in vesicles. | recently, considerable interest developed in using newer/improved antibiotics for the treatment of acne vulgaris. during this study, different roxithromycin solid-state forms (i.e. crystalline and amorphous) were encapsulated into vesicle systems (niosomes, proniosomes, ufosomes and pro-ufosomes) for dermis targeted delivery. characterization of the vesicles was done with transmission electron microscopy, light microscopy, droplet size, droplet size distribution, ph, zeta-potential and entrapmen ... | 2017 | 28119103 |
| treatment effects of lysozyme-shelled microbubbles and ultrasound in inflammatory skin disease. | acne vulgaris is the most common skin disorder, and is caused by propionibacterium acnes (p. acnes) and can induce inflammation. antibiotic therapy often needs to be administered for long durations in acne therapy, which results in extensive antibiotic exposure. the present study investigated a new treatment model for evaluating the antibacterial effects of lysozyme (ly)-shelled microbubbles (mbs) and ultrasound (us)-mediated ly-shelled mbs cavitation against p. acnes both in vitro and in vivo, ... | 2017 | 28117399 |
| inhibition of propionibacterium acnes lipase activity by the antifungal agent ketoconazole. | the common skin disease acne vulgaris is caused by propionibacterium acnes. a lipase secreted by this microorganism metabolizes sebum and the resulting metabolites evoke inflammation in human skin. the antifungal drug ketoconazole inhibits p. acnes lipase activity. we previously showed that the drug also inhibits the growth of p. acnes. thus, ketoconazole may serve as an alternative treatment for acne vulgaris, which is important because the number of antibiotic-resistant p. acnes strains has be ... | 2017 | 28111792 |
| characterisation of microbial communities within aggressive prostate cancer tissues. | an infectious aetiology for prostate cancer has been conjectured for decades but the evidence gained from questionnaire-based and sero-epidemiological studies is weak and inconsistent, and a causal association with any infectious agent is not established. we describe and evaluate the application of new technology to detect bacterial and viral agents in high-grade prostate cancer tissues. the potential of targeted 16s rrna gene sequencing and total rna sequencing was evaluated in terms of its uti ... | 2017 | 28101126 |
| development of actinobacterial resources for functional cosmetics. | actinobacteria usually produce different functional compounds for various applications. | 2017 | 28097821 |
| establishment of multiplex solid-phase strip pcr test for detection of 24 ocular infectious disease pathogens. | to establish and evaluate a new multiplex solid-phase strip polymerase chain reaction (strip pcr) for concurrent detection of common ocular infectious disease pathogens. | 2017 | 28282487 |
| performance of two blood culture systems to detect anaerobic bacteria. is there any difference? | we studied the performance characteristics of two blood culture (bc) bottles/systems, (i) bact/alert-fn plus/3d (biomérieux, marcy l'étoile, france) and (ii) bactec-lytic/9000 (becton dickinson, sparks, usa) for detection of growth and time-to-positivity (ttp) against a balanced and diverse collection of anaerobic bacterial strains (n = 48) that included reference strains (n = 19) and clinical isolates (n = 29) of 32 species (15 gram-negative and 17 gram-positive). standard suspension of bacteri ... | 2017 | 28279857 |
| skin microbiome and acne vulgaris: staphylococcus, a new actor in acne. | propionibacterium acnes (p. acnes), the sebaceous gland and follicular keratinocytes are considered the three actors involved in the development of acne. this exploratory study investigated the characteristics of the skin microbiota in subjects with acne and determined microbiota changes after 28 days of application of erythromycin 4% or a dermocosmetic. skin microbiota were collected under axenic conditions from comedones, papulo-pustular lesions and non-lesional skin areas from subjects with m ... | 2017 | 28094874 |
| bacteriological profile of ocular surface flora in meibomian gland dysfunction. | to compare the bacteriological profile of meibomian gland secretion and conjunctival cul-de-sac in subjects with and without meibomian gland dysfunction (mgd). | 2017 | 28093340 |
| future surgery after revision shoulder arthroplasty: the impact of unexpected positive cultures. | the clinical implications and treatment of unexpected positive cultures (upcs) in revision shoulder arthroplasty are not well defined. the purpose of this study was to describe results of patients with and without upcs after revision shoulder arthroplasty. | 2017 | 28087166 |
| multiple activities of punica granatum linne against acne vulgaris. | acne is a common skin condition with sebum overproduction, hyperkeratosis, propionibacterium acnes (p. acnes) and staphylococcus aureus, and inflammation. punica granatum (pomegranate) is well-known for its anti-inflammatory effects; however, few studies have discussed the anti-acne effects of pomegranate. in this study, we found that pomegranate extract (pg-e) significantly reduced p. acnes-induced edema in wistar rat ears. therefore, an evaluation platform using multiple pathogenic mechanisms ... | 2017 | 28085116 |
| frequency of propionibacterium acnes infection in prostate glands with negative biopsy results is an independent risk factor for prostate cancer in patients with increased serum psa titers. | propionibacterium acnes has recently been implicated as a cause of chronic prostatitis and this commensal bacterium may be linked to prostate carcinogenesis. the occurrence of intracellular p. acnes infection in prostate glands and the higher frequency of p. acnes-positive glands in radical prostatectomy specimens from patients with prostate cancer (pca) than in those from patients without pca led us to examine whether the p. acnes-positive gland frequency can be used to assess the risk for pca ... | 2017 | 28081259 |
| modern management of acne. | acne is a chronic inflammatory disease of the pilosebaceous unit resulting from androgen-induced increased sebum production; altered keratinisation; bacterial colonisation of hair follicles on the face, neck, chest and back by propionibacterium acnes; and an inflammatory response in the skin. the exact way these processes interact and the order in which they occur in the pathogenesis of acne are still unclear. scarring that occurs from acne, particularly severe acne, can persist a lifetime and h ... | 2017 | 28076744 |
| clinical impact of positive propionibacterium acnes cultures in orthopedic surgery. | the clinical significance of a positive culture to propionibacterium acnes in orthopedic specimens remains unclear, whether about its role as a contaminant or a pathogen, or its impact as a coinfectant. therefore, we performed a retrospective study to provide a more accurate description of the clinical impact of p. acnes in an orthopedic population aiming to determine: 1) if there is a clinical difference between p. acnes infection and contamination? 2) if there is a clinical difference between ... | 2017 | 28065868 |
| propionibacterium acnes endocarditis: a case series. | propionibacterium acnes remains a rare cause of infective endocarditis (ie). it is challenging to diagnose due to the organism's fastidious nature and the indolent presentation of the disease. the purpose of this study was to describe the clinical presentation and management of p. acnes ie with an emphasis on the methods of diagnosis. | 2017 | 28057559 |
| bacteriophage formulated into a range of semisolid and solid dosage forms maintain lytic capacity against isolated cutaneous and opportunistic oral bacteria. | resistance of bacteria to antimicrobial agents is of grave concern. further research into the development of bacteriophage as therapeutic agents against bacterial infections may help alleviate this problem. | 2017 | 28033675 |
| recognition of propionibacterium acnes by human tlr2 heterodimers. | propionibacterium acnes has been considered as a crucial contributor to the pathogenesis of acne vulgaris. the interaction between p. acnes and the host is mainly mediated by toll like receptor (tlr) 2 recognition. tlr2 homodimers recognize p. acnes in mice, but here we describe the prerequisite of tlr2/1 and tlr2/6 heterodimers in human cells for p. acnes recognition. p. acnes-induced nf-κb and ap-1activation observed in hek htlr2-transfected but not control cells confirmed the specificity of t ... | 2017 | 28024924 |
| prevention of propionibacterium acnes biofilm formation in prosthetic infections in vitro. | the role of propionibacterium acnes in shoulder arthroplasty and broadly in orthopedic prosthetic infections has historically been underestimated, with biofilm formation identified as a key virulence factor attributed to invasive isolates. with an often indolent clinical course, p acnes infection can be difficult to detect and treat. this study investigates absorbable cements loaded with a broad-spectrum antibiotic combination as an effective preventive strategy to combat p acnes biofilms. | 2017 | 27989720 |
| rhodomyrtone inhibits lipase production, biofilm formation, and disorganizes established biofilm in propionibacterium acnes. | virulence enzymes and biofilm a play crucial role in the pathogenesis of propionibacterium acnes, a major causative agent of acne vulgaris. in the present study, the effects of rhodomyrtone, a pure compound identified from rhodomyrtus tomentosa (aiton) hassk. leaves extract against enzyme production and biofilm formation production by 5 clinical isolates and a reference strain were evaluated. the degree of hydrolysis by both lipase and protease enzymes significantly decreased upon treatment with ... | 2017 | 27923605 |
| neer award 2017: a rapid method for detecting propionibacterium acnes in surgical biopsy specimens from the shoulder. | propionibacterium (p) acnes infection of the shoulder after arthroplasty is a common and serious complication. current detection methods for p acnes involve anaerobic cultures that require prolonged incubation periods (typically 7-14 days). we have developed a polymerase chain reaction (pcr)-restriction fragment length polymorphism (rflp) approach that sensitively and specifically identifies p acnes in tissue specimens within a 24-hour period. | 2017 | 27887873 |
| nonunion after clavicle osteosynthesis: high incidence of propionibacterium acnes. | the objective of this study was to review the etiology of clavicle nonunions after osteosynthesis and investigate the outcomes of a treatment with a single-stage revision. | 2017 | 27984454 |
| risk factors for propionibacterium acnes infection after neurosurgery: a case-control study. | propionibacterium acnes is increasingly known as a causative organism for post-neurosurgical infection; however, no clinical studies have examined the risk factors associated with p. acnes infections. clinical data obtained from 14 cases of p. acnes infection and 28 controls infected with other pathogens were analyzed. craniotomy, malignancy, and prolonged duration of operation were significantly associated with the onset of p. acnes infection. no fatal cases were reported. | 2017 | 27889246 |
| activity of electrical current in experimental propionibacterium acnes foreign-body osteomyelitis. | foreign-body-associated infections are often difficult to treat, given that the associated microorganisms are in a biofilm state. previously, we showed that a low-amperage direct electrical current (dc) reduces propionibacterium acnes biofilms formed on implant-associated materials in vitro in this study, low-amperage dc was compared to ceftriaxone treatment or no treatment in a novel rat femur model of foreign-body osteomyelitis. a platinum implant seeded with a p. acnes biofilm (10(7) cfu/cm(2 ... | 2017 | 27821457 |
| proteomic analysis of extracellular vesicles derived from propionibacterium acnes. | extracellular vesicle (ev) has been reported to conduct critical pathophysiological functions as an emerging mode of communication in bacteria. recently, propionibacterium acnes, an anaerobic gram-positive human commensal found in the skin and gastrointestinal tract, has drawn increasing attention as an underestimated pathogen in a variety of diseases. | 2017 | 27594576 |
| proteomic and transcriptomic investigation of acne vulgaris microcystic and papular lesions: insights in the understanding of its pathophysiology. | the pathogenesis of acne vulgaris involves several phases including androgen-dependent hyper-seborrhea, colonization by propionibacterium acnes, and inflammation. recent investigations have shown that in fact p. acnes provokes the activation of the inflammasome present in macrophages and dendritic cells. this signaling pathway leads to excessive production of interleukin il-1β, a proinflammatory cytokine. nevertheless, these well-studied phenomena in acne fail to elucidate the mechanisms respons ... | 2017 | 27789243 |
| determination of the mutant prevention concentration and the mutant selection window of topical antimicrobial agents against propionibacterium acnes. | determination of the mutant prevention concentration (mpc) and the mutant selection window (msw) of antimicrobial agents used to treat pathogenic bacteria is important in order to apply effective antimicrobial therapies. here, we determined the mpcs of the major topical antimicrobial agents against propionibacterium acnes and staphylococcus aureus which cause skin infections and compared their msws. among the mpcs of nadifloxacin and clindamycin, the clindamycin mpc was determined to be the lowe ... | 2017 | 27764829 |
| the cost effectiveness of vancomycin for preventing infections after shoulder arthroplasty: a break-even analysis. | increasing methicillin resistance and recognition of propionibacterium acnes as a cause of infection in shoulder arthroplasty has led to the adoption of local vancomycin powder application as a more effective method to prevent expensive periprosthetic infections. however, no study has analyzed the cost effectiveness of vancomycin powder for preventing infection after shoulder replacement. | 2017 | 27727049 |
| dynamic interactions between prophages induce lysis in propionibacterium acnes. | progress in next-generation sequencing technologies has facilitated investigations into microbial dynamics. an important bacterium in the dairy industry is propionibacterium freudenreichii, which is exploited to manufacture swiss cheeses. a healthy culture of these bacteria ensures a consistent cheese with formed 'eyes' and pleasant flavour profile, and the investigation of prophages and their interactions with these bacteria could assist in the maintenance of the standard of this food product. ... | 2017 | 27639668 |
| clinical features of anaerobic orthopaedic infections. | some patient populations and types of orthopaedic surgery could be at particular risk for anaerobic infections. in this retrospective cohort study of operated adult patients with infections from 2004 to 2014, we assessed obligate anaerobes and considered first clinical infection episodes. anaerobes, isolated from intra-operative samples, were identified in 2.4% of 2740 surgical procedures, of which half (33/65; 51%) were anaerobic monomicrobial infections. propionibacterium acnes, a penicillin a ... | 2017 | 27581503 |
| factors shaping the composition of the cutaneous microbiota. | from birth, we are constantly exposed to bacteria, fungi and viruses, some of which are capable of transiently or permanently inhabiting our different body parts as our microbiota. the majority of our microbial interactions occur during and after birth, and several different factors, including age, sex, genetic constitution, environmental conditions and lifestyle, have been suggested to shape the composition of this microbial community. propionibacterium acnes is one of the most dominant lipophi ... | 2017 | 27518483 |
| infections following arthroscopic rotator cuff repair: incidence, risk factors, and prophylaxis. | the primary aim of the present study was to determine the incidence of infections following arthroscopic rotator cuff repair in a single department over a 10-year period. secondary goals included the evaluation of potential risk factors for infections and to investigate the efficacy of perioperative antibiotic prophylaxis in the reduction of infectious complications. | 2017 | 27342982 |
| induction of pulmonary granuloma formation by propionibacterium acnes is regulated by myd88 and nox2. | sarcoidosis is characterized by noncaseating granulomas with an unknown cause that present primarily in the lung. propionibacterium acnes, an immunogenic commensal skin bacterium involved in acne vulgaris, has been implicated as a possible causative agent of sarcoidosis. here, we demonstrate that a viable strain of p. acnes isolated from a patient with sarcoidosis and instilled intratracheally into wild-type mice can generate pulmonary granulomas similar to those observed in patients with sarcoi ... | 2017 | 27607191 |
| is it time to switch on or off the green light for ultraviolet-induced red fluorescence as a surrogate marker for propionibacterium acnes in vivo? | 2017 | 27307204 | |
| strain-level differences in porphyrin production and regulation in propionibacterium acnes elucidate disease associations. | propionibacterium acnes is an important skin commensal, but it is also considered a pathogenic factor in several diseases including acne vulgaris, the most common skin disease. while previous studies have revealed p. acnes strain-level differences in health and disease associations, the underlying molecular mechanisms remain unknown. recently, we demonstrated that vitamin b12 supplementation increases p. acnes production of porphyrins, a group of proinflammatory metabolites important in acne dev ... | 2017 | 27303708 |
| assessment of anaerobic blood cultures in pediatric oncology patients. | the routine use of a single aerobic bottle for blood culture in pediatric patients has become commonplace, as anaerobic bacteria are not frequently involved in clinically significant infections. the aim of this study was to assess the usefulness of routinely performing anaerobic blood cultures in pediatric oncology patients. | 2017 | 27221161 |
| cross-sectional pilot study of antibiotic resistance in propionibacterium acnes strains in indian acne patients using 16s-rna polymerase chain reaction: a comparison among treatment modalities including antibiotics, benzoyl peroxide, and isotretinoin. | antibiotic resistance is a worldwide problem in acne patients due to regional prescription practices, patient compliance, and genomic variability in propionibacterium acnes, though the effect of treatment on the resistance has not been comprehensively analyzed. | 2017 | 26955094 |
| a rare case of delayed onset capsular block syndrome managed using 25-gauge vitrector. | we report a case of delayed onset capsular block syndrome in a patient 6 years after undergoing cataract surgery. ocular examination revealed marked diminution of vision accompanied with a collection of milky fluid between the intraocular lens and posterior capsule. to treat and to understand the pathology of the condition, aspiration of fluid using 25-gauge vitrector through pars plana was done, and contents sent for microbiological analysis which did not reveal any growth. postoperative period ... | 2017 | 26903727 |
| epidemiology of deep surgical site infections after pediatric spinal fusion surgery. | single-institution, retrospective case series. | 2017 | 27306257 |
| propionibacterium acnes infection after shoulder surgery. | propionibacterium acnes has been implicated as a cause of infection following shoulder surgery, may occur up to 2 years after the index operation and has been shown to be responsible for up to 56% of shoulder infections after orthopedic implant. male patients within the population undergoing shoulder surgery are particularly at risk, especially if their shoulder surgery involved prosthesis or was posttraumatic. p. acnes infection can be difficult to diagnose clinically and laboratory techniques ... | 2017 | 26622132 |
| inhibition of lipase and inflammatory mediators by chlorella lipid extracts for antiacne treatment. | acne vulgaris is a chronic inflammatory disease, and its treatment is challenging due to the multifactorial etiology and emergence of antibiotic-resistant propionibacterium acnes strains. this study was focused to reduce antibiotics usage and find an alternate therapeutic source for treating acne. lipid extracts of six chlorella species were tested for inhibition of lipase, reactive oxygen species (ros) production, cytokine production using p. acnes (microbial type culture collection 1951). lipa ... | 2017 | 25709963 |
| sunscreen remanence on the skin: a noninvasive real time in vivo spectral analysis assessing the quenching of specular ultraviolet a light reflectance. | under specific light illumination, particularly ultraviolet radiation (uvr), the skin produces both specular light reflectance and, possibly, specific fluorescent emission. a quenching effect of fluorescence is observed following the application of sunscreens active against uva radiations. | 2016 | 26260120 |
| propionic acid produced by propionibacterium acnes strains contri-butes to their pathogenicity. | propionibacterium acnes is an important member of the skin microbiome. the bacterium can initiate signalling events and changes in cellular properties in keratinocytes. the aim of this study was to analyse the effect of the bacterium on an immortalized human keratinocyte cell line. the results show that various p. acnes strains affect the cell-growth properties of these cells differentially, inducing cytotoxicity in a strain-specific and dose-dependent manner. we propose that bacterially secrete ... | 2016 | 26039371 |
| investigation of antibacterial activity of aspidin bb against propionibacterium acnes. | in the present study, antibacterial activity of four kinds of phloroglucinol derivatives extracted from dryopteris fragrans (l.) schott against s. aureus, s. epidermidis and p. acnes has been tested. aspidin bb exerted the strongest antibacterial activity with minimal inhibition concentration (mic) values ranging from 7.81 to 15.63 μg/ml. the time-kill assay indicated that aspidin bb could kill p. acnes completely at 2 mic (mbc) within 4 h. by using afm, we demonstrated extensive cell surface al ... | 2016 | 26596576 |
| effect of surgical delay on bacterial colonization in proximal humeral fractures. | postoperative infection is a severe complication after proximal humeral fracture surgical treatment. the aim of this study was to determine if the surgical delay could modify the number and type of bacteria on the surgical site. a two stages study was set up. in the first stage the effect of delay was simulated in 20 patients affected by proximal humeral fracture treated conservatively. in a second stage, the effect of delay was measured in 20 patients that underwent surgery. in stage 1, three s ... | 2016 | 26580139 |
| [low grade endophthalmitis caused by p. acnes : case report]. | low grade endophthalmitis is usually a chronic indolent inflammation that may be misdiagnosed as noninfectious uveitis. therefore, this form of endophthalmitis is often unsuccessfully treated with corticosteroids. we describe the case of a patient with low grade endophthalmitis caused by propionibacterium acnes after cataract surgery. this case report presents the difficulties in establishing the diagnosis of this form of endophthalmitis as well as the benefits of a combined operative therapy wi ... | 2016 | 26531293 |
| multicenter cross-sectional observational study of antibiotic resistance and the genotypes of propionibacterium acnes isolated from chinese patients with acne vulgaris. | antibiotics are widely applied in management of acne vulgaris, which raises the issue of antibiotic resistance. due to improper application and supervision of antibiotics, antibiotic resistance has become a serious problem in china. so, the efficacy of antimicrobial therapy in acne is unclear without an objective monitor of antibiotic resistance of propionibacterium acnes. this cross-sectional, multicenter observational study is aimed at understanding the status of antibiotic resistance in p. ac ... | 2016 | 26508505 |
| the cultivable microbiota of primary and secondary infected root canals, their susceptibility to antibiotics and association with the signs and symptoms of infection. | to examine the presence of microbial species in primary and secondary infections and identify the signs and symptoms associated with them. | 2016 | 26011084 |
| the culturome of the human nose habitats reveals individual bacterial fingerprint patterns. | the complex anatomy of the human nose might offer distinct microbial niches. microbiota composition may affect nose inflammatory diseases and staphylococcus aureus carriage. considering different nasal cavity locations, microbial colonization was analysed across individuals exhibiting chronic nasal inflammatory diseases (n = 18) and those without local inflammation signs (n = 16). samples were collected systematically during surgery and examined by an extensive culture-based approach and, for a ... | 2016 | 25923378 |
| antimicrobial activities of ozenoxacin against isolates of propionibacteria and staphylococci from japanese patients with acne vulgaris. | ozenoxacin, a novel non-fluorinated topical quinolone, was assessed for in vitro antimicrobial activity against clinical isolates of propionibacteria and staphylococci according to the broth microdilution method recommended by the clinical and laboratory standards institute. the isolates used in this study were collected from japanese patients with acne vulgaris during a period from 2012 to 2013. the mic90s of ozenoxacin against propionibacterium acnes (n=266), propionibacterium granulosum (n=10 ... | 2016 | 27305898 |
| compressive spinal epidural mass caused by propionibacterium acnes. | propionibacterium acnes is a gram-positive and facultative anaerobe bacillus that is found within sebaceous follicles of the human skin and recognized as a cause of infections after spinal surgery. to our knowledge, there has been no previously reported case of symptomatic compressive chronic inflammatory epidural mass caused by p. acnes in a patient with no prior spinal procedures. | 2016 | 26721733 |
| deciphering the effect of novel bacterial exopolysaccharide-based nanoparticle cream against propionibacterium acnes. | acne vulgaris (acne) is a chronic inflammatory disease prevalent among adolescents and adults, with significant psychological effects. the aetiology of acne is multifactorial. several pathophysiological associations have been identified in which propionibacterium acnes plays a major role. this bacteria primarily affects areas containing oil glands including the face, back and trunk, where it causes the formation of seborrhoea and inflammatory lesions. the treatment methods currently in place hav ... | 2016 | 28330105 |
| staphylococcus aureus carriage rates and antibiotic resistance patterns in patients with acne vulgaris. | overuse of antibiotics has led to the development of antibiotic-resistant strains of staphylococcus aureus, which are occurring more frequently within the community. | 2016 | 26777099 |
| propionibacterium acnes in shoulder surgery: is loss of hair protective for infection? | propionibacterium acnes (p acnes) has been linked to chronic infections in shoulder surgery. it was recently observed during first-time shoulder surgery in healthy patients at a rate between 36% and 56%. male gender and the anterolateral approach were reported risk factors. because the skin biology greatly differs, we aimed to correlate skin complaints with p acnes-positive intraoperative cultures from different tissue layer samples in patients undergoing shoulder surgery for the first time. | 2016 | 26763856 |
| rapid diagnosis of propionibacterium acnes infection in patient with hyperpyrexia after hematopoietic stem cell transplantation by next-generation sequencing: a case report. | the rapid determination of pathogenic agent is very important to clinician for guiding their clinical medication. however, current diagnostic methods are of limitation in many aspects, such as detecting range, time-consuming, specificity and sensitivity. in this report, we apply our new-developing pathogen detection method to clarify that propionibacterium acnes is the causative agent of a two-year-old boy with juvenile myelomonocytic leukemia presenting clinical symptoms including serious rash ... | 2016 | 26743541 |
| staphylococcal lta-induced mir-143 inhibits propionibacterium acnes-mediated inflammatory response in skin. | staphylococcus epidermidis (s. epidermidis) plays a critical role in modulating cutaneous inflammatory responses in skin. although s. epidermidis has been shown to co-colonize with propionibacterium acnes (p. acnes) in acne lesions, it is unclear whether s. epidermidis is involved in the regulation of p. acnes-induced inflammatory responses. in this study, we demonstrated that s. epidermidis inhibited p. acnes-induced inflammation in skin. p. acnes induced the expression of interleukin-6 and tum ... | 2016 | 26739093 |
| [bacterial resistance in acne? a meta-analysis of the controversy]. | acne is one of the dermatological pathologies with the highest incidence around the world. it is a multifactorial disease and its treatment can be complex. propionibacterium acnes play a key role in the inflammation of this dermatosis. topical antibiotics, including mainly erythromycin and clindamycin, have been used, but there is controversy over their use due to the widely documented bacterial resistance. for this reason a meta-analysis of the publications over the past 10 years is presented i ... | 2016 | 26738649 |
| microorganisms inhabiting follicular contents of facial acne are not only propionibacterium but also malassezia spp. | to clarify the relationship between major cutaneous microorganisms (propionibacterium, staphylococcus and malassezia spp.) and acne vulgaris (acne), we examined the microbiota quantitatively in the follicular contents of inflammatory acne and on the facial skin of patients with acne. fifteen japanese untreated acne outpatients were studied. the follicular contents from inflammatory acne lesions of the face were collected using a comedo extractor. the skin surface samples were obtained by the swa ... | 2016 | 26705192 |
| propionibacterium acnes in primary shoulder arthroplasty: rates of colonization, patient risk factors, and efficacy of perioperative prophylaxis. | recent literature has shown that propionibacterium acnes can be cultured from superficial and deep layers of the shoulder. our aims were to assess the rate of p. acnes colonization in patients undergoing primary shoulder arthroplasty, to identify patient-related risk factors, and to evaluate the efficacy of our perioperative antisepsis protocol. | 2016 | 26704361 |
| association between lumbar disc degeneration and propionibacterium acnes infection: clinical research and preliminary exploration of animal experiment. | clinical research and animal experiment. | 2016 | 26656049 |
| microbial colonization of normal skin: direct visualization of 194 skin biopsies. | recent genetic studies have suggested the presence of numerous microbial species on and in the skin. we characterised microbial colonization of a large collection of skin biopsies from 194 healthy subjects by fluorescence assay. forty per cent of all biopsies did not show any evidence for microbial colonization. propionibacterium acnes was the sole predominant bacterial species in both sebaceous and non-sebaceous areas. non- p. acnes species were present in approximately 30% of all colonized sam ... | 2016 | 26655456 |
| staphylococcus epidermidis sets things right again. | commensal cutaneous bacteria are believed to play a role in skin homeostasis, possibly by counteracting the effects of pathogenic inflammation. in this issue, xia et al. show that staphylococcus epidermidis is involved in the regulation of propionibacterium acnes-induced inflammation. staphylococcal lipoteichoic acid induces mir-143, which in turn inhibits toll-like receptor 2 mrna to decrease toll-like receptor 2 protein and consequently suppresses p. acnes-induced proinflammatory cytokines. | 2016 | 26902125 |
| guidelines of care for the management of acne vulgaris. | acne is one of the most common disorders treated by dermatologists and other health care providers. while it most often affects adolescents, it is not uncommon in adults and can also be seen in children. this evidence-based guideline addresses important clinical questions that arise in its management. issues from grading of acne to the topical and systemic management of the disease are reviewed. suggestions on use are provided based on available evidence. | 2016 | 26897386 |
| high-throughput sequencing of cerebrospinal fluid for diagnosis of chronic propionibacterium acnes meningitis in an allogeneic stem cell transplant recipient. | a 40-year-old man with chronic myelogenous leukemia presented multiple times over a period of 3 years with episodes of confusion, wide-based gait and falls because of recurrent hydrocephalus despite repeated therapeutic lumbar punctures. these problems occurred in the context of persistent cerebrospinal fluid (csf) pleocytosis and leptomeningeal enhancement. extensive diagnostic workups and therapeutic trials had failed to identify a clinically plausible cause or produce any significant improvem ... | 2016 | 26895706 |
| glycerol monolaurate inhibits lipase production by clinical ocular isolates without affecting bacterial cell viability. | we sought to determine the relative lipase production of a range of ocular bacterial isolates and to assess the efficacy of glycerol monolaurate (gml) in inhibiting this lipase production in high lipase-producing bacteria without affecting bacterial cell growth. | 2016 | 26873514 |
| do sublaminar polyester bands affect the outcomes of postoperative infections after adolescent idiopathic scoliosis surgery? | the incidence of surgical site infections (ssi) after adolescent idiopathic scoliosis (ais) surgery ranges from 0.5% to 7%. there is currently a regain of interest in hybrid constructs, combining lumbar pedicle screws and thoracic sublaminar bands, but some authors have raised concerns about the risk of ssi and the difficulty of bacterial eradication. the goal of this study was therefore to assess the outcomes of ssi after ais surgery using sublaminar bands. | 2016 | 26866646 |
| systematic review of antibiotic resistance in acne: an increasing topical and oral threat. | topical and oral antibiotics are routinely used to treat acne. however, antibiotic resistance is increasing, with many countries reporting that more than 50% of propionibacterium acnes strains are resistant to topical macrolides, making them less effective. we reviewed the current scientific literature to enable proposal of recommendations for antibiotic use in acne treatment. references were identified through pubmed searches for articles published from january, 1954, to march 7, 2015, using fo ... | 2016 | 26852728 |
| effects of magnesium ascorbyl phosphate on the expression of inflammatory biomarkers after treatment of cultured sebocytes with propionibacterium acnes or ultraviolet b radiation. | 2016 | 26848238 | |
| wide-spectrum activity of a silver-impregnated fabric. | fabrics, such as clothing, drapes, pillowcases, and bedsheets are potential sources of pathogenic bacteria and viruses. we found fabrics (ie, professional clothing, pillowcases, and lab coats) treated with a silver-impregnated material to be effective in significantly reducing a wide spectrum of ordinary and drug-resistant microorganisms, including salmonella, methicillin-resistant staphylococcus aureus, propionibacterium acnes, trichphyton mentagrophytes, and norovirus. fabrics impregnated with ... | 2016 | 26827093 |
| overview: the role of propionibacterium acnes in nonpyogenic intervertebral discs. | propionibacterium acnes (p. acnes), an important opportunistic anaerobic gram-positive bacterium, causes bone and joint infections, discitis and spondylodiscitis. accumulated evidence suggested that this microbe can colonise inside intervertebral discs without causing symptoms of discitis. epidemiological investigation shows that the prevalence ranges from 13 % to 44 %. furthermore, colonisation by p. acnes inside nonpyogenic intervertebral discs is thought to be one pathogen causing sciatica, m ... | 2016 | 26820744 |
| propionibacterium acnes: disease-causing agent or common contaminant? detection in diverse patient samples by next-generation sequencing. | propionibacterium acnesis the most abundant bacterium on human skin, particularly in sebaceous areas.p. acnesis suggested to be an opportunistic pathogen involved in the development of diverse medical conditions but is also a proven contaminant of human clinical samples and surgical wounds. its significance as a pathogen is consequently a matter of debate. in the present study, we investigated the presence ofp. acnesdna in 250 next-generation sequencing data sets generated from 180 samples of 20 ... | 2016 | 26818667 |
| in vitro antimicrobial activity of benzoyl peroxide against propionibacterium acnes assessed by a novel susceptibility testing method. | benzoyl peroxide (bpo), a therapeutic agent for acne vulgaris, was assessed for in vitro antimicrobial activity against propionibacterium acnes using a novel broth microdilution testing that improved bpo solubility. we searched for a suitable culture medium to measure the minimum inhibitory concentration (mic) of bpo against p. acnes and finally found the gifu anaerobic medium (gam) broth supplemented with 0.1(v/v)% glycerol and 2(v/v)% tween 80, in which bpo dissolved up to 1250 μg/ml and p. ac ... | 2016 | 26806150 |
| follicular fluorescence quantity to characterize acne severity: a validation study. | porphyrins are native fluorophores in the follicle openings, visible under ultraviolet-a light. acne severity might be associated with increased propionibacterium acnes colonization and porphyrin production. aim of this study was to investigate whether the parameter fluorescence quantity can be used to measure acne severity. | 2016 | 26804729 |
| antimicrobial activities of ethanol and butanol fractions of white rose petal extract. | white rose (rosa hybrida) petals were extracted with ethanol (etoh) or butanol (buoh), and tested for their antimicrobial activities against two species of gram-positive bacteria, six species of gram-negative bacteria, and two species of fungi. on in vitro antimicrobial assays, helicobacter pylori and propionibacterium acnes were highly susceptible to white rose petal extract (wrpe)-etoh and wrpe-buoh, leading to minimal inhibitory concentrations of 100 and 10 μg/ml for h. pylori and 400 and 40 ... | 2016 | 26802535 |
| evaluation of anti-microbial activities of zno, citric acid and a mixture of both against propionibacterium acnes. | in this study, anti-microbial activities of zno of three different particle sizes of citric acid (ca) and of mixtures of zno and ca were confirmed against propionibacterium acnes. | 2016 | 26940755 |
| characteristics and treatment outcomes of propionibacterium acnes prosthetic shoulder infections in adults. | background. prosthetic joint infections (pjis) significantly complicate joint arthroplasties. propionibacterium acnes is an increasingly recognized pji pathogen, yet limited clinical and therapeutic data exist. we sought to examine characteristics of p. acnes shoulder pjis and compare surgical and nonsurgical management outcomes. methods. a retrospective analysis of p. acnes shoulder pjis was conducted at an academic center in baltimore, maryland from 2000 to 2013. results. of 24 cases of p. ... | 2016 | 26933665 |
| a combination of ellagic acid and tetracycline inhibits biofilm formation and the associated virulence of propionibacterium acnes in vitro and in vivo. | propionibacterium acnes is an opportunistic pathogen which has become notorious owing to its ability to form a recalcitrant biofilm and to develop drug resistance. the current study aimed to develop anti-biofilm treatments against clinical isolates of p. acnes under in vitro and in vivo conditions. a combination of ellagic acid and tetracycline (etc; 250 μg ml(-1) + 0.312 μg ml(-1)) was determined to effectively inhibit biofilm formation by p. acnes (80-91%) without affecting its growth, therefo ... | 2016 | 26930280 |
| modic changes and disc degeneration caused by inoculation of propionibacterium acnes inside intervertebral discs of rabbits: a pilot study. | to investigate whether p. acnes could induce disc degeneration and modic changes when inoculated into the discs of rabbits. | 2016 | 26925420 |
| antagonism between staphylococcus epidermidis and propionibacterium acnes and its genomic basis. | propionibacterium acnes and staphylococcus epidermidis live in close proximity on human skin, and both bacterial species can be isolated from normal and acne vulgaris-affected skin sites. the antagonistic interactions between the two species are poorly understood, as well as the potential significance of bacterial interferences for the skin microbiota. here, we performed simultaneous antagonism assays to detect inhibitory activities between multiple isolates of the two species. selected strains ... | 2016 | 26924200 |
| the role of topical dermocosmetics in acne vulgaris. | acne is a common chronic inflammatory disease and treatment modalities based on acne severity are well established. the role of dermocosmetics in dermatology, and in particular acne, is becoming more important as more research elucidates the mechanisms of action of products in the pathogenesis of acne. dermocosmetics have the potential to be used as monotherapy or in combination with medical treatment. therefore, it has become important for dermatologists to understand dermocosmetics to effectiv ... | 2016 | 26916232 |
| frequent isolation of propionibacterium acnes from the shoulder dermis despite skin preparation and prophylactic antibiotics. | in vitro, propionibacterium acnes (p acnes) is highly susceptible to commonly used antibiotics and antiseptics, yet in vivo, it still causes postsurgical infections of the shoulder. we hypothesized that the local environment within the pilosebaceous glands protects p acnes and that incision of the skin transects these glands, exposing viable p acnes to the wound. | 2016 | 26456428 |
| evaluation of anti-acne properties of phloretin in vitro and in vivo. | this study aimed to investigate the anti-acne properties of phloretin in vitro and in vivo. | 2016 | 26212527 |
| bilateral sequential propionibacterium acnes exogenous endophthalmitis. | a 68-year-old man underwent uncomplicated sequential cataract extractions performed more than a year apart. he presented 6 months after the second surgery with persistent intraocular inflammation in both eyes. cultures from both eyes grew propionibacterium acnes and he responded well to treatment. suspicion for delayed-onset post-operative endophthalmitis must remain high in uveitis cases that fail to resolve with anti-inflammatory treatments. the authors believe this is the first reported case ... | 2016 | 27220771 |
| clinical features of infectious keratitis caused by propionibacterium acnes. | propionibacterium acnes is a commensal bacteria whose pathogenicity in infectious keratitis is unclear. in this study, we report infectious keratitis cultured with p. acnes and evaluate its clinical characteristics. | 2016 | 27203796 |
| pulmonary fibrosis in a mouse model of sarcoid granulomatosis induced by booster challenge with propionibacterium acnes. | pulmonary fibrosis (pf) associated with chronic sarcoidosis remains poorly understood, and no experimental model is currently available for this condition. previous studies have shown that propionibacterium acnes (pa) was associated with sarcoidosis and induced granuloma formation in mice. here, we investigated whether repeated challenge with pa induces persistent inflammation leading to sarcoidosis followed by pf in mice. specifically, c57bl/6 mice were inoculated intraperitoneally and subjecte ... | 2016 | 27203210 |
| first cultivation of health-associated tannerella sp. hot-286 (bu063). | despite significant advances in recent years in culture-independent molecular microbiology methods, the detailed study of individual bacterial species still relies on having pure cultures in the laboratory. yet, more than a third of the approximately 700 bacterial taxa found in the human oral cavity are as yet uncultivated in vitro. one such taxon, tannerella sp. hot-286 (phylotype bu063), is the focus of much interest since it is associated with periodontal health, while tannerella forsythia, i ... | 2016 | 27193146 |