Publications

clinical and laboratory evaluation of a commercial kit for measurement of serum free thyroxin ("amerlex free t4").	different indexes of thyroid function were determined in conjunction with values obtained with a new commercial radioimmunoassay kit for serum free thyroxin, in 49 apparently healthy subjects, 87 pregnant women, and 142 outpatients attending the thyroid clinic. the results indicate a diagnostic success rate of 88% when free thyroxin was measured instead of estimating the so-called free thyroxin index. furthermore, in three cases of papillary carcinoma the concentration of free thyroxin was incre ...	1983	6848256
hypothyroidism as a cause of hypertension.	to study whether there is an association between hypertension and hypothyroidism, measurements of blood pressure and thyroid function were determined in 477 female patients with chronic thyroiditis. based on the blood levels of thyroxine (t4) and thyroid stimulating hormone (tsh), 308 patients were considered euthyroid and 169 were hypothyroid [t4 = 2.9 +/- 0.1 micrograms/dl and tsh = 105.8 +/- 6.8 microu/ml (mean +/- sem)]. diastolic, but not systolic, blood pressure in hypothyroid patients ove ...	1983	6848458
excision repair and dna synthesis with a combination of hela dna polymerase beta and dnase v.	the ability of hela dna polymerases to carry out dna synthesis from incisions made by various endodeoxyribonucleases which recognize or form baseless sites in dna was examined. dna polymerase beta carried out limited strand displacement synthesis from 3'-hydroxyl nucleotide termini made by hela apurinic/apyrimidinic (ap) endonuclease ii at the 5'-side of apurinic sites. escherichia coli endonuclease iii incises at the 3'-side of apurinic sites to produce nicks with 3'-deoxyribose termini which d ...	1983	6848490
differentiation stages of human natural killer cells in lymphoid tissues from fetal to adult life.	virtually all human granular lymphocytes expressed the hnk-1 differentiation antigen when examined in lymphoid compartments from adults, neonates, and fetuses. the hnk-1+ cells were distinguishable into three subsets having distinct antigenic phenotypes: hnk+t3-m1-, hnk+t3+m1-, and hnk+t3-m1+. thus, greater than 70% of the hnk-1+ cells from 13-17 wk fetuses (less than 0.2% of nucleated cells) lacked t cell antigens (e.g., t3, t8, t4, and t6) and the m1 myeloid antigen. morphologically, the hnk+t ...	1983	6848618
adaptation to hypocaloric feeding: physiologic significance of the fall in serum t3 as measured by the pulse wave arrival time (qkd).	we have investigated the physiologic significance of the decline in serum triiodothyronine (t3) occurring during hypocaloric feeding by measurement of changes in cardiovascular function. the qkd interval, the interval between the q wave of the electrocardiogram and the onset of korotkoff sounds at diastolic pressure at the brachial artery, is the sum of the preejection period and pulsetransmission time, and has proven to be a sensitive and effective measure of the effect of thyroid hormones on t ...	1983	6848901
a link between liver microsomal enzyme activity and thyroid hormone metabolism in man.	1 the effect of different combinations of liver microsomal enzyme inducing drugs on thyroidal hormone steady state concentrations was investigated. three groups of healthy volunteers were given daily either antipyrine 1200 mg together with phenobarbitone 100 mg, antipyrine 1200 mg combined with rifampicin 600 mg or rifampicin 600 mg alone for a period of 14 days. 2 before and after each treatment the total body clearance of antipyrine, gamma-glutamyl transferase (gamma-gt), 6 beta-oh-cortisol as ...	1983	6849748
thyroid hormones in the sudden infant death syndrome (sids).	results are presented of serum total t4, t3, and tsh measurements on 92 patients. there are 34 infants exhibiting the sudden infant death syndrome, 36 in control group 1, who are matched both for age of infant and for duration of storage of specimen, and 22 post-mortem sera from non-sids deaths. there is no significant difference between the groups for total t4 measurements, but there is a highly significant elevation of both total serum t3 and tsh in the sids group compared with control group 1 ...	1983	6851158
a quantitative study of the electroencephalographic response to levodopa treatment in parkinsonian patients.	a quantitative eeg study was done in order to confirm previous impressions that there is a significant eeg response to levodopa in parkinsonian patients, and in order to trace the existence of dopaminergic mechanisms in the generation of the human eeg. eegs of twenty-five parkinsonian patients were recorded both before and during levodopa treatment, two to four weeks apart, when levodopa doses reached maintenance levels of 3-5g/d. derivations from f7-t3, f8-t4, t5-o1, and t6-o2 were recorded and ...	1983	6851190
[studies on free thyroxine measurement with radioimmunoassay kit--evaluation of liquisol free t4 kit].		1983	6851206
thyroid status in patients with chronic renal failure.	serum thyroid hormone concentrations have been measured in 21 patients with chronic renal failure, treated conservatively and compared with values from 19 control subjects. many patients had serum total t3 and t4 concentrations below the reference ranges. the concentrations of free t4 and free t3 and the free thyroxine index were significantly lower in patients with abnormal total concentrations of the thyroid hormones than in the controls. both the free and the total concentrations of t4 correl ...	1983	6851253
transplacental effects of 3,5-dimethyl-3'-isopropyl-l-thyronine on fetal hypothyroidism in primates.	pregnant rhesus monkeys treated with 131i at midgestation become hypothyroid and produce fetuses without demonstrable thyroid tissue. in an effort to prevent both maternal and fetal hypothyroidism, we treated 131i-treated pregnant monkeys with 3,5-dimethyl-3'-isopropyl-l-thyronine (dimit), a thyroid hormone analog with structural changes which facilitate placental transfer. five pregnant monkeys were treated with 131i (mci/kg) at 83-87 days of gestation. one week later, three monkeys were starte ...	1983	6851937
changes in tissue concentrations of thyrotropin, free thyrotropin beta, and alpha-subunits after thyroxine administration: comparison of mouse hypothyroid pituitary and thyrotropic tumors.	we have previously demonstrated divergent changes in pituitary free tsh beta and alpha-subunit concentrations in hypothyroid mice during prolongation of experimental hypothyroidism and after t4 administration. this report compares the simultaneous responses of pituitary and thyrotropic tumor tsh, tsh beta, and alpha-subunit to 12 days of t4 administration in four groups of hypothyroid laf1 mice bearing thyrotropic tumors. half of each group received daily injections of t4 (10 micrograms/100 g bw ...	1983	6851938
in vivo study of iodothyronine deiodination in rat liver: effect of salicylate on biliary excretion of several iodothyronines.	biliary excretion of total (i.e. conjugated plus unconjugated) thyroxine (t4), 3,5,3'-triiodothyronine (t3), 3,3',5'-triiodothyronine (rt3), 3,5-diiodothyronine (3,5-t2), 3,3'-diiodothyronine (3,3'-t2) and 3',5'-diiodothyronine (3',5'-t2) was measured with the aid of specific radioimmunoassay in 17 control rats and in 31 rats injected sodium salicylate i.v. (200 mg kg-1). the animals were anesthetized with pentobarbiturate and the samples of bile were taken in subsequent 2 h periods from a drain ...	1983	6852770
t4 phage deoxyribonucleotide-synthesizing enzyme complex. further studies on enzyme composition and regulation.		1983	6853543
effects of cholecystographic agents and sulfobromophthalein on binding of thyroid hormones to serum proteins.	a number of interactions between thyroid hormones and cholecystographic agents have previously been demonstrated. in the present study we show that cholecystographic agents also interfere with the binding of thyroid hormones to serum proteins. a commercial kit (tri-tab) was used in which the uptake of labeled hormone from serum by a silicate adsorbent tablet is measured. in the presence of cholecystographic agents or sulfobromophthalein (bsp), the amount of labeled hormone bound to adsorbent inc ...	1983	6853679
clinical assessment of a radioimmunoassay for free thyroxine using a modified tracer.	a radioimmunoassay for measuring free thyroxine in plasma was introduced by amersham using a i-125-labeled t4 derivative that does not bind significantly to the thyroxine-binding proteins. we evaluated this ria for its clinical utility in assessing 278 patients with thyroid and nonthyroidal diseases. the precision of the amerlex free t4 assay, expressed as coefficient of variation, was 20% at 0.16 ng/dl, 6.9% at 0.55 ng/dl, 4.2% at 1.08 ng/dl, 5.3% at 2.29 ng/dl, and 6.3% at 3.18 ng/dl. a refere ...	1983	6854399
structural comparisons of some small spherical plant viruses.	the structures of tomato bushy stunt virus, southern bean mosaic virus and satellite tobacco necrosis virus have been compared quantitatively. the organization of the shell domains of tomato bushy stunt virus and southern bean mosaic virus within the icosahedral envelope is identical. the wedge-shaped end of the subunit is closer to the fivefold or quasi-sixfold axes in all three viruses but the packing about the three- and twofold axes is quite different in satellite tobacco necrosis virus as c ...	1983	6854630
[spontaneous remission of t4-toxicosis caused by multiple "hot" thyroid nodules].		1983	6856507
[effect of thyroxine on the integrity of chromosomes].	some features of the mechanism of thyroxin (t4) mutagenic effect in the culture of the human peripheral blood lymphocytes and the rat liver in vivo were studied. it was shown, that t4 mutagenic effect, discovered previously in the entire organism, can be stipulated by direct hormone-cell interaction. t4 mutagenic effect is associated with a change in dna-dependent rna polymerase activity and is realized during different phases of the cellular cycle. t4 modifying influence upon chromosome entiret ...	1983	6856598
radiobiological effects of 131i and 125i on the dna of the rat thyroid. i. comparative study with emphasis on the postradiation hypothyroidism occurrence.	one of the major disadvantages of the use of 131i in the treatment of thyrotoxicosis is the development of hypothyroidism. alternatively, 125i has been proposed for thyrotoxicosis therapy, and was thought to be preferable to 131i because of the short range of its emitted soft electrons. several studies have shown 125i to be as effective as 131i in the treatment of thyrotoxicosis, and equally likely to produce hypothyroidism. this work compared the radiobiological effects of 131i and 125i given i ...	1983	6856755
work in progress: californium-252 brachytherapy plus fractionated irradiation for advanced tonsillar carcinoma.	a feasibility trial of californium-252 neutron brachytherapy combined with fractionated cobalt-60 therapy for advanced but localized stage t4 tonsillar-retromolar carcinoma is described. seven patients with primary tumors who were not suitable for conventional radical surgery, chemoradiotherapy and surgery, or surgery plus irradiation were treated. there was complete tumor response in all cases.	1983	6856844
nasopharyngeal carcinoma in the second decade of life.	the clinical findings and treatment results in 27 patients, 11 to 20 years of age, with nasopharyngeal carcinoma were retrospectively reviewed. the histological diagnosis was lymphoepithelioma in 18 patients and undifferentiated carcinoma in nine patients. seven patients (26%) presented with t4 lesions, 24 patients (89%) with clinically positive cervical nodes, and two patients (7%) with distant metastases. all patients received radiation therapy to the primary site; chemotherapy was employed as ...	1983	6856845
thyroid hormone responses in hemorrhagic shock: study in dogs and preliminary findings in humans.	one hour of hemorrhagic shock in the dog produces alterations in thyroid hormone metabolism far exceeding those seen after elective surgery or thermal injury. the changes in plasma thyroid hormone levels cannot be fully explained by carrier protein loss. plasma concentrations of total thyroxine (t4) and triiodothyronine (t3) were significantly decreased after only 20 minutes of shock, continued to decrease throughout shock and resuscitation, and remained depressed for several days thereafter. bo ...	1983	6857495
synthesis of 2'(3')-o-dl-alanyl hexainosinic acid using t4 rna ligase: suppression of the enzymic reverse transfer reaction by alkaline phosphatase.	2'(3')-o-dl-alanyl (ip)5i was synthesized by a new method. an alanine ortho ester of inosine 5'-phosphate was added to (ip)4i using the atp-independent reaction of t4 rna ligase, and the product was converted smoothly to the desired ester. the enzymic reverse transfer reaction was conveniently suppressed by the dephosphorylation of the adenosine 5'-phosphate coproduct, catalyzed in situ by alkaline phosphatase.	1983	6857753
the endocrine control of the initiation and growth of antlers in white-tailed deer.	five fawn and 5 adult white-tailed deer (odocoileus virginianus) were maintained in individual pens, fed a complete diet, and bled bi-weekly for one year. blood serum was analyzed for testosterone (t), androstenedione (a), thyroxine (t4), calcium (ca), phosphorus (p) and alkaline phosphatase (ap). adults grew velvet antlers from mid-april and shed their velvet in mid-september. hardened antlers were cast in march. fawns grew velvet antler buttons which hardened in february and cast in march, pri ...	1983	6858547
effects of prolonged administration of thyrotrophin on serum concentration, release and synthesis of thyroid hormones in mice.	mice were injected sc with tsh (0.5 u) at 12 h intervals for 5 days. groups of mice were sacrificed daily to determine serum t4 and t3 concentrations, 4 h thyroidal 125i uptake, distribution of 125i among thyroidal iodoamino acids, and thyroidal content of t4 and t3. serum t4 and t3 concentrations increased significantly after the initial injection of tsh and gradually decreased thereafter, reaching initial levels on the 3rd and 4th days, respectively. in contrast to serum hormone levels, thyroi ...	1983	6858549
effects of hysterectomy and uterine extracts on growth hormone, somatomedin, prolactin, thyrotrophin and thyroid hormones in adult rats.	plasma concentrations and anterior pituitary content of growth hormone (rgh), thyroid stimulating hormone (rtsh), and rat prolactin (rprl) as well as the plasma concentrations of triiodothyronine (t3), thyroxine (t4) and somatomedin a (sm-a) have been determined in intact, castrated or hysterectomized adult rats with and without treatment with steroid-free, crude uterine extracts. hysterectomy caused a significant increase in the plasma gh but decrease in the plasma tsh concentrations. injection ...	1983	6858551
suppression and stimulation of tsh and thyroid hormones in bulls during starvation and refeeding.	sixteen bull calves were fasted during two periods, 31/2 and 7 months old. blood samples were taken every 6 h during an experimental period of 9 days: 2 control days, 5 fasting days and 2 refeeding days. during the control days with ad libitum feeding, t3, t4 and tsh increased during the day. during the fasting period, t4 decreased with a half-life of 3.5 days and t3 with a half-life of 3 days. tsh decreased in a less regularly way to a mean of 60% of control mean. six h after refeeding, tsh had ...	1983	6858555
neonatal hypothyroidism: effect on the circadian variation of serum tsh in adult male rats.	newborn rats were rendered hypothyroid during the first post-natal week and then studied as adults. at 80 days of age, groups of control and neonatally treated animals were sacrificed at the peak (13.00 h) and trough (07.00 h) of the serum thyroid stimulating hormone (tsh) circadian rhythm. both control and treated animals showed the normal peak and trough fluctuation of serum tsh, although the animals made hypothyroid neonatally had serum tsh levels which were less than those of the control ani ...	1983	6858556
[isolation of biologically active halves of the long tail fibers and whiskers of bacteriophage t4].	the following substructural elements of bacteriophage t4 have been isolated in homogeneous and biologically active state: the whole long tail fibrils, distal and proximal halves of the long tail fibrils and whiskers. it has been shown that during the infection of escherichia coli with t4 amber-mutants (defective in the genes coding for heads and tails), the major part of distal and proximal fibril halves found within the cell appears to be unassociated. the interaction of distal and proximal fib ...	1983	6860712
differential response of an ovarian-responsive mouse mammary tumor to androgenic and estrogenic agents.	an ovarian-responsive mammary tumor subline, t4-or26, was isolated from an outgrowth of a progressed tpdmt-4 pregnancy-dependent mammary tumor in a virgin ddd mouse. t4-or26 tumors were characterized by significantly faster growth in virgin mice than in ovariectomized mice. both estrogen and progesterone were important for growth of the subline, as they were for that of the parent. tamoxifen (tam), with estrogenic activity, and epithiostanol (epi) and testosterone propionate, with androgenic act ...	1983	6861137
"unbound analog" radioimmunoassays for free thyroxin measure the albumin-bound hormone fraction.	we have assessed the influence of albumin-bound thyroxin (t4) on apparent free t4 values obtained by two "unbound analog" free t4 methods (amerlexr free t4 and clinical assays one-step free t4). we evaluated sera showing three different albumin anomalies: total hereditary analbuminemia, partially corrected analbuminemia, and familial dysalbuminemic hyperthyroxinemia, where abnormal albumin-binding of analog tracer is associated with high apparent free t4 values by these methods. in hereditary an ...	1983	6861347
nuclear binding and cellular metabolism of thyroxine in a euthyroid patient with hyperthyroxinaemia.	the receptor mechanism and intracellular t4 deiodination were studied in a patient, who was euthyroid despite high t4 levels. serum t3 and serum reverse t3 levels were normal and the trh tests produced a normal rise in tsh. protein binding capacities for t4 in serum were found to be normal. the t4 bound to a single set of binding sites in the patient's lymphocyte nuclei with a ka which was depressed as compared with that of normals (ka = 2.8 x 10(10) 1/mol) and a maximum specific binding capacit ...	1983	6861366
prolactin--thyroid interaction in fundulus heteroclitus.	injections of adult fundulus heteroclitus with 0.2 iu of otsh over 4 days caused an increase in serum t4, with no effect on serum t3. administration of 12 iu of oprl in conjunction with the same dosage of tsh prevented the tsh-induced rise in t4, without affecting serum t3 levels. the failure of tsh to cause t4 levels to rise in the presence of prl may result from either inhibition of release or acceleration of metabolic clearance of t4. we therefore conducted three experiments to examine potent ...	1983	6862166
endemic goiter in vietnam.	endemic goiter involves about 15% of the population of vietnam. to define the role of various factors which contribute to endemic goiter in vietnam, we surveyed 935 people in vancon, a lowland commune with goiter appearing only in the past decade, and 619 people in dich giao, a highland commune with endemic goiter treated erratically with iodized salt. in dich giao, cassava, a goitrogenic food, constitutes half of the dietary caloric intake. the prevalence of goiter was 45% in vancon and 28% in ...	1983	6863473
amniotic fluid concentrations of iodothyronines and thyrotropin do not reliably predict fetal thyroid status in pregnancies complicated by maternal thyroid disorders or anencephaly.	in this study we report measurements of amniotic fluid (af) concentrations of iodothyronines and tsh in 69 normal and 16 complicated pregnancies. the latter group included 2 women with untreated hyperthyroidism, 1 patient with untreated hypothyroidism, 5 hyperthyroid patients who received propylthiouracil (3 with graves' disease, 1 with a multinodular goiter, and 1 with chronic thyroiditis), 3 women with graves' disease who were hypothyroid after treatment, but who were receiving replacement the ...	1983	6863480
measurement of thyroxine conversion to triiodothyronine using human lymphocytes. a useful and simple laboratory technique.	the deiodination of t4 to t3 has been studied after incubation of whole lymphocytes with different t4 concentrations, followed by a t3 radioimmunological determination performed on unextracted samples. the lymphocytes were isolated from blood from normal volunteers of both sexes and different age classes as well as from myxedematous subjects and patients with low t3 syndrome. the t3 production, in normal subjects, expressed as pmol/10.10(6) cells was 0.41 +/- 0.75 (t4 = 4.10(-7) m, n = 12), 1.43 ...	1983	6863848
serum t4, t3, and tsh levels in primary hypothyroidism during replacement therapy with thyroxine.	forty-five patients with primary hypothyroidism were studied during the first 4 to 36 months of replacement therapy with thyroxine. all became clinically euthyroid (23 patients while taking 0.1 mg/d, 14 patients while taking 0.15 mg/d, 7 patients while taking 0.2 mg/d, and 1 patient while taking 0.25 mg/d) over a period of three to six months. the patients were then divided for data analysis into two groups. group i had normal serum t3 levels, normal (or elevated) serum t4 levels, and normal ser ...	1983	6865774
goose lysozyme structure: an evolutionary link between hen and bacteriophage lysozymes?	during evolution, the amino acid sequence of a protein is much more variable and changes more rapidly than its tertiary structure. given sufficient time, the amino acid sequences of proteins derived from a common precursor may alter to the point that they are no longer demonstrably homologous. the ability to make meaningful comparisons between such distantly related proteins must therefore come primarily from structural homology, and only secondarily (if at all) from sequence homology. on the ot ...	1983	6866082
polyribosome binding of rabbit globin messenger rna and messenger ribonucleoprotein labelled with bacteriophage-t4 rna ligase and 5'-[32p] phosphocytidine 3'-phosphate.	rabbit polyribosomal globin messenger rna (mrna) and messenger ribonucleoprotein (mrnp) were labelled at the 3' poly(a) tail to high specific activity with t4 rna ligase and [5'-(32)p]pcp without consequent loss of functional activity. labelled message was translated in both micrococcal nuclease treated and untreated rabbit reticulocyte lysates, as shown by the formation of labelled polyribosomes. the utilisation of labelled messenger was abolished by t2 toxin or sodium fluoride which are known ...	1983	6866762
[does pvp-iodine disinfection of newborn infants cause transient hypothyroidism? report on 6 cases and prospective study of 19 early operated infants using t4 and tsh determinations of dried blood samples].		1983	6867656
strumal carcinoid of the ovary: an immunohistochemical and electron microscopic study.	a case of strumal carcinoid of the ovary is reported. the follicles contained t4-immunoreactive substance, whereas the carcinoid component of the tumor had a trabecular structure and showed argyrophilic elements. pancreatic-polypeptide and enteroglucagon were localized in these cells by an immunocytochemical method. the same cells displayed small electron-dense endocrine-like granules. a common precursor for the thyroid and carcinoid components is postulated.	1983	6868143
neonatal hyperthyroidism: effects on sympathetic responses to stress in adult rats.	treatment of developing rats with thyroid hormone results in accelerated maturation of sympathetic and adrenal medullary responses to reflex activation of central sympathetic outflow. in this study, we examined the effects of neonatal hyperthyroidism on the responsiveness of the sympathetic nervous system of adult rats to acute stress. hyperthyroidism was produced in long-evans hooded rats by injections of thyroxine (neo-t4, 1 mg/kg body wt) on postnatal days 1-4. littermate controls received in ...	1983	6869580
neuromuscular blockade in infants following intramuscular succinylcholine in two or five per cent concentration.	this study determined the characteristics of the neuromuscular block which followed intramuscular succinylcholine 4 mg . kg-1 in 20 infants during halothane anaesthesia. the infants were divided into two groups of ten; the first received succinylcholine in two percent solution and the second in five per cent solution. the mean maximum depression of the first twitch of the train-of-four (t1) was 89.7 +/- 5.0 per cent in 4.0 +/- 0.6 min, and the mean full recovery of t1 occurred in 15.6 +/- 0.9 mi ...	1983	6871775
initiation of transcription at phage t4 late promoters with purified rna polymerase.	we have previously identified t4 late promoters governing the in vivo expression of t4 late genes 23 and 24 (p23 and p24). t4 late transcription in vivo is known to involve the binding of at least five phage-coded proteins to the bacterial rna polymerase and normally requires concurrent dna replication for dna template activation. we show here that in vitro transcription, primarily of plasmids carrying t4 genes 23 and 24, by rna polymerase purified from escherichia coli at late times after t4 in ...	1983	6871999
preincubation of thyroxine with sulfhydryl-reducing agents does not stimulate thyroxine inner or outer ring deiodination.	sulfhydryl reagents stimulate enzymatic conversion of t4 to t3 and rt3. a recent study suggested that such reagents stimulated t4 5'-deiodination by a direct interaction with t4. we therefore tested the ability of dithiothreitol (dtt) and other sulfhydryl reagents to enhance the susceptibility of t4 and rt3 to 5'-deiodination by liver homogenates and of t4 to 5-deiodination by placental homogenates. preincubation of t4 with dtt in concentrations ranging from 0.5-80 mm did not result in increased ...	1983	6872956
modulating effect of glutathione disulfide on thyroxine-5'-deiodination by rat hepatocytes in primary culture: effect of glucose.	to investigate whether an increase in the intracellular glutathione disulfide (gssg) concentration actually regulates t4-5'-deiodination in intact cells, rat hepatocytes in primary culture were exposed to glutathione-oxidizing agents (diamide and tertiary butylhydroperoxide) or vinblastine, and their effects on 5'-deiodination of t4 were studied. deiodinating activity was determined from the 125i- fraction released from [3',5'-125i]t4 added to the serum-free culture medium. total glutathione (t- ...	1983	6872957
propylthiouracil (ptu) pharmacology in the rat. ii. effects of ptu on thyroid function.	using a sensitive and specific ria for propylthiouracil (ptu), we examined the effects of short term (1 week) and long term (1 month) ptu treatment on thyroid function in the rat, and correlated changes in thyroid function with serum and thyroid ptu levels. after 1 week, dose-dependent decreases in thyroid pbi, serum t4, and serum t3 were observed, with concomitant elevations in the serum rt3 to t4 ratio and serum tsh. fifty percent suppression of thyroid pbi occurred at a ptu concentration in t ...	1983	6872961
[nonuniformity of the descending pathways activating the sympathetic preganglionic neurons of the superior thoracic segment of the spinal cord].	in anesthetized, immobilized and artificially ventilated cats, excitatory influences from the ventrolateral part of medulla are mediated to sympathetic preganglionic neurons of t2 segment via two types of descending pathways with conduction velocity 12.3 +/- 3.2 m/sec and about 6 m/sec. the descending excitatory influences on sympathetic neurons of t4 and more caudal segments are mediated via pathways of the latter type only. according to characteristics of the white rami responses elicited by s ...	1983	6873359
extralaryngeal spread of cancer of the larynx: a study with whole-organ sections.	thirty total laryngectomy and five pharyngolaryngoesophagectomy specimens were studied with the whole-organ sectioning technique. the horizontal plane of sectioning was chosen to study the pattern and degree of extralaryngeal spread in carcinoma of the larynx. there were 22 transglottic, 6 supraglottic, and 7 infraglottic tumors. among them there were 1 t1, 2 t2, 5 t3, and 27 t4 lesions. spreading anteriorly, the tumor was found to penetrate the thyrohyoid membrane in 7 (32%) out of 22 transglot ...	1983	6874365
iodine and thyroid hormone levels in serum and urine of full term newborn infants.	in 19 full term newborn boys serum levels of thyroxine (t4), triiodothyronine (t3), thyrotropin (tsh) and thyroxine binding globulin (tbg) were determined on the first and fifth day of life using radioimmunoassays. t4 and t3 were also measured in 24-h urine collections as well as total iodine in urine and in breast milk. a significant decrease occurred in serum concentrations of t4, t3 and tsh from day 1 to 5 while tbg remained unchanged. at the same time an increase of total iodine (1.7 to 4.1 ...	1983	6874381
anorexia nervosa with hyperthyroidism: case report.	clinical signs of hypometabolism in anorexia nervosa may result from the "low triiodothyronine syndrome," in which thyroxine (t4) and thyroid stimulating hormone are usually normal, but triiodothyronine (t3) is in a range compatible with hypothyroidism. a case in which anorexia nervosa presented with unsuspected hyperthyroidism is reported.	1983	6874653
interferon-induced changes in expression of antigens defined by monoclonal antibodies on malignant and nonmalignant mononuclear hematopoietic cells.	the effect of alpha interferon (alpha ifn) on the expression of histocompatibility--as well as differentiation antigens on normal and malignant hematopoietic mononuclear cells--were investigated by cell cytofluorometry using a panel of monoclonal antibodies (moabs). an increase in the expression of hla-antigens detected by beta 2-microglobulin (beta 2-m) could be demonstrated for peripheral blood mononuclear cells, non-t cells, null cells, activated t cells, fetal thymocytes, adherent cells, and ...	1983	6875313
natural and synthetic analogues of melatonin and related compounds. ii. effects on plasma thyroid hormones and cholesterol levels in male syrian hamsters.	synthetic or natural analogues of the pineal indole, melatonin, were injected separately every evening (1700 hours) for 7 (exp. 1) or 10 (exp. 2) weeks into adult male syrian hamsters maintained in 14 hours of light and 10 hours of darkness each day. plasma thyroxine (t4) levels were significantly depressed by 25 micrograms/day of melatonin (amt) in both experiments. injecting 25 micrograms/day either of acetyl methoxytryptophol or of synthetic analogues (hexanoyl methoxytryptamine, propionyl me ...	1983	6875534
salivary thyroxine as an estimate of free thyroxine: concise communication.	to test the hypothesis that the levels of salivary thyroxine (t4) reflect those of circulating free t4, we developed a radioimmunoassay (ria) sensitive to low levels of t4. concurrent saliva and serum samples were obtained from 32 euthyroid volunteers, ages 19-64. salivary and serum t4 and cortisol levels were measured by ria. salivary albumin was measured by nephelometry. salivary t4 levels were higher than predicted, 4.2-35 ng/dl (normal range 0.6-2.0). no correlation was found between salivar ...	1983	6875679
effects of sulfonamide on the pituitary-thyroid gland. 1. morphological changes of thyroid gland and variation in plasma thyroxine and triiodothyronine.	morphological changes of the thyroid gland on light and electron microscopy as well as concomitant variation in plasma t3 and t4 levels after oral treatment with sulfonamide at a dose of 2 g/kg for 30 consecutive days were examined in male wistar rats. several rats were treated with the same dose by the same route for 15 days and then put to the restoration experiment for 15 days. plasma t3 and t4 levels significantly decreased as compared with the control in the period from the 1st day to the 3 ...	1983	6876203
[changes in thyroid hormone levels following severe burns treated topically with povidone-iodine].	the serum concentrations of thyroxine (t4), triiodothyronine (t3) and tsh as well as the effective thyroxine ratio (etr) and the resin-t3-uptake (rt3u) were studied in 23 severely burned patients during the whole time of hospitalisation. topical treatment was carried out with povidone-iodine. in all patients t4 and t3 concentrations decreased significantly during the first two weeks especially in extensive burns. lack of increase was a bad prognostic sign. etr and rt3u underwent no remarkable ch ...	1983	6877006
thyroid hormones in human milk and their influence on thyroid function of breast-fed babies.	various assay methods for detection of thyroid hormones in human milk were evaluated in recovery and dilution experiments after which the concentrations of thyroxine (t4) and 3,5,3'-triiodothyronine (t3) were measured and compared with those in serum. the effect of breast feeding on pituitary thyroid function of normal babies also was studied. competitive protein-binding analysis (cpba) was found to be unsuitable for measurement of t4 in milk. t4 was not detected in samples of human milk by four ...	1983	6877900
assessment of thyroid functional reserve in the cat by the thyrotropin-stimulation test.	serum thyroxine (t4) concentrations before and after various iv doses of bovine thyrotropin (tsh) were measured over a 48-hour period in 19 healthy cats. base-line t4 values, as measured by radioimmunoassay, varied greatly. the peak t4 concentration occurred 6 hours after tsh injection, and there was an increase in post-tsh serum t4 concentration that was linearly related to the logarithm of the dose. greatest stimulation was seen with the highest dose used (1 u of tsh/kg of body weight), and 6 ...	1983	6881661
[treatment of congenital hypothyroidism by l-thyroxine in solution. posology].	a solution of levothyroxine (5 micrograms/drop) has been used in congenital hypothyroidism detected after neonatal screening. optimal doses were variable among individual patients. with 5-7 micrograms/kg during the first month of treatment, then 4 to 5 micrograms/kg, it was usually possible to obtaining normal plasma t4, which seems more important that to normalize tsh. overdosage is to be avoided as well as insufficiency of treatment.	1983	6882127
[thyroid ectopia, a cause of error in neonatal screening for hypothyroidism].	the authors report the case of a boy presenting with hypothyroidism due to ectopic thyroid, diagnosed at age 3 years. the results of neonatal screening for hypothyroidism (t4 + tsh) had been normal. a large ectopic thyroid might have been responsible for normal levels of thyroid hormone at birth.	1983	6882132
[determination of haptoglobin by agglutination with anti-hp on latex particles].	human sera are able to agglutinate latex particles sensitized with antihaptoglobin serum produced from sheep. the agglutination depends on the haptoglobin types. similar to the agglutination of t4-streptococci the titer of hp 1-1 is very low and the titers of sera of the types hp 2-1 and hp 2-2 are 1:160 or higher.	1983	6882404
serum thyroglobulin in acute and chronic liver disease.	in view of the widespread use of serum thyroglobulin determination in the follow-up of patients with differentiated thyroid carcinoma, the influence of acute and chronic liver disease on serum thyroglobulin concentration was investigated in thirty-seven consecutive patients with histologically proven alcoholic liver cirrhosis and twenty-three patients with acute non-alcoholic hepatitis. seventy-four healthy volunteers served as controls. serum thyroglobulin concentration was significantly elevat ...	1983	6883738
[structural organization of the baseplate of phage t4].		1983	6884190
[thyroid function in patients chronically treated with amiodarone].	the effects of amiodarone (1000-1400 mg/week, for a period ranging from 3 to 24 months) on thyroid gland function were studied in 45 patients with heart disease, using a new method of free thyroid hormone assay. forty-four untreated patients and 11 normal subjects were used as controls. in treated patients the prevalence of dysthyroidism was 22,2% (15,6% hypothyroidism and 6,6% hyperthyroidism); the onset of dysthyroidism ranged from 20 days to 2 years after the beginning of treatment. in contro ...	1983	6884652
persistence of a circadian rhythmicity for thyroid hormones in plasma and thyroid of hibernating male rana ridibunda.	the presence and circadian rhythmicity of thyroid hormones was studied in plasma and the thyroid gland of male rana ridibunda before and during hibernation. hibernating january frogs do have a lower t3 and t4 content of their thyroid gland whereas plasma levels of t3 are maintained and of t4 increased compared to fed september or october frogs. it seems likely that the increased photoperiod in january will be responsible for this increased t4 secretion, since controlled laboratory experiments pe ...	1983	6884746
reverse t3 in rainbow trout, salmo gairdneri.	plasma levels, peripheral metabolism and extrathyroidal in vivo production of reverse t3 (rt3 = 3,3',5'-triiodo-l-thyronine) were studied in rainbow trout at 12 degrees c. plasma rt3 levels (less than 40 pg/ml) corresponded to the detection limit of the radioimmunoassay. by in vitro analysis, a high proportion (0.95%) of rt3 added to plasma existed in the free (dialyzable) form. injected [125i]rt3 was cleared more rapidly from plasma (minimum mcr = 7.7 ml/hr/100 g) than t3. no phenolic (outer ri ...	1983	6884747
influence of potassium thiocyanate on thyroid function of rainbow trout, salmo gairdneri.	sublethal doses of potassium thiocyanate (kscn), an iodide competitor, depressed thyroidal radioiodide uptake of fed laboratory rainbow trout at 11 degrees, but did not depress either plasma levels of t4 (l-thyroxine) and t3 (triiodo-l-thyronine) or radioiodide incorporation into plasma iodothyronines. furthermore, plasma t4 levels of kscn-treated trout increased to levels comparable to those of control trout in response to bovine tsh. the apparent inability of kscn to inhibit thyroid hormone sy ...	1983	6884760
lowering of serum total t3 during a conventional slimming regime.	serum concentrations of total triiodothyronine (t3) and thyroxine (t4) were determined in 28 obese out-patients before and after 12 weeks of treatment with a conventional slimming diet of 5.2 mj (1245 kcal). twenty-one of the patients were also given central stimulating anorectics (diethylpropion and 'elsinore-pill' containing ephedrine). the median weight loss was 8.1 kg (range 0.4-19.1 kg). after the treatment a small, but significant (p less than 0.02), fall in serum t3 could be demonstrated ...	1983	6885228
squamous cell carcinoma of the maxillary sinus: analysis of 66 cases.	a retrospective review was performed of 66 patients with squamous cell carcinoma of the maxillary sinus. the majority of patients presented with tumors classified as t3 (31.8%) and t4 (54.5%). seven (10.6%) patients presented initially with neck metastases and 13 (19.7%) patients subsequently developed regional disease. for the 66 patients studied, the observed 5 and 10 year actuarial survival rate was 27.3% and 20.7% respectively. the presence of cervical metastases, particularly when they deve ...	1983	6885504
a preformed, topologically stable replication fork. characterization of leading strand dna synthesis catalyzed by t7 dna polymerase and t7 gene 4 protein.	this paper describes the construction of a dna molecule containing a topologically stable structure that simulates a replication fork. this preformed dna molecule is a circular duplex of 7.2 x 10(3) base pairs (m13mp6 dna) from which arises, at a unique bamhi recognition site, a noncomplementary 5'-phosphoryl-terminated single strand of 237 nucleotides (sv40 dna). this structure has two experimental attributes. 1) templates for both leading and lagging strand synthesis exist as stable structures ...	1983	6885816
polyclonal 3,5,3'-triiodothyronine (t3) antibodies in a euthyroid woman and their effect on radioimmunoassays for t3.	thyroid function tests in a 17-yr-old euthyroid woman with a slightly enlarged thyroid gland were normal, except for an apparently elevated serum t3 level which was over 8 times greater than the upper limit of normal, when her serum was directly analyzed for t3 by an antibody-coated tube ria method. when t3 analysis was performed with a ria procedure that also used serum directly and separated free and bound radiolabeled hormone by polyethylene glycol precipitation, an absurd and conflictingly l ...	1983	6885968
effect of a tryptophan deficiency on thyroid gland, growth hormone and testicular functions in chickens.	broiler chicks from 2 to 4 weeks of age were fed control (0.23%) and deficient (0.115, 0.058%) levels of l-tryptophan. separate groups of control chicks were pair-fed daily with the deficient chicks. deficient chicks grew less efficiently than did pair-fed controls. plasma triiodothyronine (t3) was elevated in deficient chicks, especially compared to pair-fed controls, and this was accompanied by lower reverse t3. plasma thyroxine (t4) was also reduced with 0.059% tryptophan. however, thyroid we ...	1983	6886823
in vivo cleavage of cytosine-containing bacteriophage t4 dna to genetically distinct, discretely sized fragments.	mutants of bacteriophage t4d that are defective in genes 42 (dcmp hydroxymethylase), 46 (dna exonuclease), and 56 (dctpase) produce limited amounts of phage dna in escherichia coli b. in this dna, glucoylated 5-hydroxymethylcytosine is completely replaced by cytosine. we found that this dna rapidly becomes fragmented in vivo to at least 16 discrete bands as visualized on agarose gels subjected to electrophoresis. the sizes of the fragments ranged from more than 20 to less than 2 kilobase pairs. ...	1983	6887350
evidence for a repeating cross-beta sheet structure in the adenovirus fibre.	the amino acid sequence of the adenovirus fibre protein reveals an approximately repeating motif of 15 residues. a diagonal comparison matrix established that these repeats extended from residue 43 to residue 400 of the 581 residue sequence. assignment of secondary structure combined with model building showed that each 15-residue segment contained two short beta-strands and two beta-bends, one of which incorporated an extra residue in a beta-bulge of the gx type. the 44 strands together gave a ...	1983	10872331
the effect of alpha particles on bacteriophage t4br+.	it is generally accepted that heavy charged particles play an important part in generating the secondary flux of nuclear particles formed by the interaction of space hadrons with nuclei. it is assumed that these particles are responsible for the high biological efficiency of space hadrons in causing cellular damage by their strong interactions. to examine this assumption we investigated the effects of 5.3 mev alpha particles on bacteriophage t4. this energy provides a let value of 88.6 kev/micro ...	1983	11542756
degrees of relatedness of t-even type e. coli phages using different or the same receptors and topology of serologically cross-reacting sites.	the relatedness of a series of t-even like phages which use the escherichia coli outer membrane protein ompa as a receptor, and the classical phages t2, t4 and t6 has been investigated. immunoelectron microscopy and the pattern of phage resistance in bacterial mutants revealed that: (i) phages of this morphology do not necessarily cross-react serologically; (ii) phages using different receptors may bind heterologous igg everywhere except to the tip (comprising approximately 10% of one fiber poly ...	1983	11894952
toxicology and ntp carcinogenesis studies of a polybrominated biphenyl mixture (firemaster ff-1) in f344/n rats and b6c3f1 mice (gavage studies).	firemaster ff-1, a flame retardant composed of polybrominated biphenyls (pbb), was responsible for widespread environmental contamination and animal losses in michigan starting in 1973. this study was undertaken to characterize the long-term toxic and carcinogenic potential of this pbb mixture in rats and mice of each sex. fisher 344/n rats and b6c3f1 mice were given 125 oral doses of pbb over a 6-month period--0, 0.1, 0.3, 1.0, 3.0, or 10.0 mg/kg body weight/day (5 days/week). a dose-related de ...	1983	12750749
ligation of endogenous trna 3' half molecules to their corresponding 5' halves via 2'-phosphomonoester,3',5'-phosphodiester bonds in extracts of chlamydomonas.	trna preparations from chlamydomonas and wheat germ contain small amounts of trna 5' halves and corresponding 3' halves. incubation of cell-free extracts from the two sources with [gamma-p]atp yielded 5'-p-labeled trna 3' halves which were joined to their corresponding 5' counterparts to form mature trna containing 2'-phosphomonoester,3', 5'-phosphodiester bonds. trna 3' halves labelled with t4 kinase were purified, sequenced and also joined to their 5' counterparts. it is proposed that these tr ...	1983	16453445
effect of thyroid hormone supplementation on chronic doxorubicin (adriamycin)-induced cardiotoxicity and serum concentrations of t3 and t4 in dogs.	chronic doxorubicin (adriamycin; adr) intoxication was produced in beagle dogs by weekly iv injections (1 mg/kg of body weight) for 20 weeks (cumulative dose 400 mg of adr/m2). group a (5 dogs) were given adr only; group b (5 dogs), adr and daily supplements of 0.5 mg of l-thyroxine (t4) (twice the recommended maintenance dose); and group c (5 dogs), adr and 2.0 mg of t4 daily (8 times the recommended maintenance dose). the control group d (5 dogs) was given 0.5 mg of t4 daily. the adr-induced c ...	1982	6891885
diurnal mitochondrial changes in avian retinal pigment epithelium: a search for correlation with thyroid state.	the avian retinal pigment epithelium (rpe) is well endowed with mitochondria, 10-15% of which appear to be "donut-shaped". the number of such mitochondria presenting ring profiles varies with the photoperiod, with a peak early in the dark period and a low early in the light period. this cycle is inversely correlated with the diurnal rhythm of plasma thyroxine (t4), but is in phase with the t3 cycle. we could detect no effect on the numbers of ring mitochondria when exogenous tsh, t4 or t3 was in ...	1982	6892343
immunoglobulin binding of thyroid hormones in a case of waldenstrom's macroglobulinemia.	this paper describes a case of hypothyroidism in a patient with waldenström's disease in which the evidence of thyroid failure was accompanied by an abnormal binding of thyroid hormones in the gamma-globulin fraction. a 68-yr-old patient with waldenström's disease appeared to be hypothyroid by clinical and laboratory criteria. serum tsh was elevated; serum t3 (measured by ria) was low, while t4 levels were undetectable or very high according to the method used. serum free thyroid hormones were i ...	1982	6801074
comparison of pituitary-thyroid function in patients with endstage renal disease and in age- and sex-matched controls.	the response to i.v. bolus thyrotropin-releasing hormone (trh) of 14 dialysis patients with end-stage renal disease (esrd) was compared to the response of 14 age- and sex-matched renal clinic patients (controls) with normal renal function (serum creatinine concentrations less than 1.2 mg/dl). the mean basal serum levels of thyrotropin (tsh) were similar in the two groups. there was no difference between the two groups in the mean maximal increase in tsh after trh (6.3 microu/ml and 7.2 microu/ml ...	1982	6803061
serum t4, t3 and tbg concentrations during puberty in males.	measurements of serum thyroxine (t4), thyroxine binding globulin (tbg), and triiodothyronine (t3), using ria, were conducted in healthy israeli boys, 149 children from the age 8 years were divided into five groups according to tanner's puberty stages. the correlation with tanner's staging showed a significant decrease in t4 and tbg concentrations during puberty. however, t3 decreased only toward the last stage of puberty (between p4 to p5). our data indicate that during puberty in male subjects ...	1982	6807675
prolactin response to thyrotropin-releasing hormone in children with turner's syndrome and hyperthyroidism.	plasma prolactin (prl) response to synthetic thyrotropin-releasing hormone (trh) was studied in 26 prepubertal and 19 pubertal children with constitutional short stature, 7 patients with turner's syndrome and 10 patients with hyperthyroidism. the mean basal concentrations of plasma prl did not differ among groups. in prepubertal children prl responses to trh were comparable in both sexes, while pubertal children plasma prl levels after trh in females were significantly higher (p less than 0.05) ...	1982	6807677
thyroid function and chronic hepatosplenic schistosomiasis: peripheral conversion of thyroxine to 3,5,3'-triiodothyronine and pituitary-thyroid relationship.	the relationship between chronic hepatosplenic schistosomiaisis (ches) and circulating thyroid hormones as well as the tsh response to trh were investigated in 41 hospitalized ches patients and compared to those in 11 patients with non-ches cirrhosis with severe hepatic failure. ches patients were subdivided into 3 groups depending on the severity of parenchymal dysfunction, based upon a composite clinical and laboratory index. angiographic and hemodynamic studies of ches patients revealed alter ...	1982	6808003
human lymphocytes with either the okt4 or okt8 phenotype produce interleukin 2 in culture.	in this study, we demonstrate that both highly purified t4+ and t8+ lymphocytes can produce substantial amounts of interleukin 2(il 2) when stimulated with the combination of concanavalin a (con a) and phorbol myristate acetate. furthermore, addition of il 1 to macrophage-depleted t lymphocytes significantly increased il 2 production by lymphocytes of either the t4+ or t8+ phenotype. these findings provide a basis for further studies of the molecular mechanisms involved in human immune cell inte ...	1982	6808028
[the metabolism of thyroid hormones in chronic renal insufficiency].	the levels of tri-iodothyronine (t3), free t3 index (ft3i), thyroxine (t4), free t4 index (ft4i), thyrothopine (tsh), reverse t3(rt3), t3 resin uptake (t3u) and thyroxine-binding globulin (tbg) were investigated in 30 conservatively treated euthyrodic kidney patients with varying degrees of disturbance to kidney function. the authors found that the phenomena of the so-called "low t3 syndrome" (low t3 and ft3 while t4 is low to normal and ft4 and tsh are normal) appear not only in patients with a ...	1982	6808788
tests of thyroid function important to the ophthalmologist.	the most useful tests to establish a diagnosis of endocrine exophthalmos are the following: to prove that thyroid gland activity is increased: serum t3 and t4 assays. to demonstrate immunologic abnormalities: thyroid antibody testing and the tda test. to demonstrate an abnormal hypothalamic-pituitary-thyroid axis: the trh test. to demonstrate enlarged ocular muscles: orbital ultrasonography and computerized tomography.	1982	6809298
hyperthyroxinemia in patients with acute psychiatric disorders.	thyroid function tests were measured in 645 patients admitted to an acute psychiatric disorders unit. thirty-three percent had elevated serum thyroxine (t4), and 18 percent had an elevated free t4 index (fti). serum triiodothyronine (t3) was low, normal, or minimally elevated in 77 patients, with a high initial free t4 index. twenty-two patients with an initial elevation of their free t4 index were serially followed (study group). serum t4, free t4 index, and free t4 fell in every patient: serum ...	1982	6807087
thyroid hormone formation catalyzed by human thyroid peroxidase: a new and physiological measurement of thyroid peroxidase.	this report describes a method for measurement of tpo activity by the amount of thyroid hormone production. thyroid hormone formation was accomplished by incubating purified iodine-poor tg with human tpo for 60 min at 37 c in the presence of free dit, ki, and an h2o2 source. newly formed t3 and t4 were measured by radioimmunoassay of the tg hydrolysates. with this method, tpo-catalyzed iodination of tg and thyroid hormone formation were measured simultaneously from eight normal thyroid glands an ...	1982	6895910
[a study on anti-t3 and anti-t4 autoantibodies found in two sisters with juvenile hypothyroidism due to hashimoto's thyroiditis (author's transl)].	anti-thyroid hormone autoantibodies were found in two sisters of short stature (case 1: 13 years old, case 2: 10 years old). physical examination revealed clinical findings of hypothyroidism with diffuse goiter. a diagnosis of hashimoto's thyroiditis was made by open biopsy of the thyroid gland in both patients. serum levels of t3 and t4 were assayed by double antibody radioimmunoassay. in case 1, serum t3 level was 16 ng/dl and serum t4 level was 2.0 microgram/dl. in case 2, serum t3 levels wer ...	1982	6896035
[clinical evaluation of serum free t4 in patients with low ts syndrome and pregnant patients with thyroid diseases (author's transl)].		1982	6896175
aggravation of thyrotoxicosis in early pregnancy and after delivery in graves' disease.	the effect of pregnancy on the clinical course of graves' disease was examined by studies on 41 pregnancies in 35 patients with graves' disease, who were considered to be in a state of remission or near remission and were not receiving antithyroid drugs, during and after delivery. eighteen of the 41 cases (44%) showed transient increases in the serum free t4 index (ft4 index) during weeks 10--15 of pregnancy, but normal thyroid function in the second and third trimesters. similar transient incre ...	1982	6896207
[relation between hypoxia and thyroid function].	in view of the preponderant role of thyroid hormone in the regulation of oxygen consumption it is easy to understand the interest that has always been aroused by the study of the relationships between thyroid function and hypoxia. thus far the results obtained have often been contrasting, demonstrating now an increase, now a reduction in thyroid function as evidenced by variations in the thyroid function parameters investigated (t3, t4, tsh, pbi), thyroscintigraphy, captation curves, histologica ...	1982	6896558
[the changes in the serum thyroid hormone concentrations in graves patients with congestive heart failure the onset of t4 toxicosis (author's transl)].		1982	6896721
what is the significance of raised plasma tsh levels after thyroid surgery?	thyroid function was assessed prospectively for five years in 73 patients treated surgically for graves's disease. no patient developed hypothyroidism after the sixth postoperative month, despite the presence of raised plasma tsh levels in 70 per cent of euthyroid patients at the end of the first year. indeed, in those with evidence of temporary hypothyroidism (low t4, raised tsh at 3 months but normalisation of t4 at 6 months) plasma tsh continued to fall for up to three years. the majority (6) ...	1982	6896766
sequential deiodination of thyroxine in human thyroid gland.	the inner ring monodeiodination [t4 to rt3, t3 to 3,3'-diiodothyronine(3,3'-t2)] as well as the outer ring monodeiodination (t4 to t3, rt3 to 3,3'-t2) was demonstrated with thyroid tissues obtained from patients with graves' disease by measuring the products by rias. sequential deiodination of t4 to 3,3'-t2 was also recognized in normal human thyroid glands. these iodothyronine deiodinations were dependent on incubation time, tissue volume, temperature, ph, and concentration of dithiothreitol. t ...	1982	6896880
anterior pituitary, thyroid, parathyroid and adrenal responses to subtotal thyroidectomy in patients with graves' disease.	changes in the serum levels of anterior pituitary, thyroid, parathyroid, and adrenal hormones following subtotal thyroidectomy in 31 patients with graves' disease were investigated. in 14 patients, rapid acth tests were performed on the preoperative and the first, third, and seventh post-operative days. remarkable differences were not seen with regard to the changes in anterior pituitary hormones or cortisol, compared to those seen during general surgery. as to the thyroid hormones, the serum le ...	1982	6896895
[pharmacological influences on fetal lung maturity, part v: influencing the pulmonary dpl (dipalmitoyl lecithin) level with l-thyroxin (t4)].	dipalmitoyl lecithin (dpl = dppc, dipalmitoyl phosphatidyl choline) is both quantitatively and functionally the most important constituent of the surfactant complex. the effect of thyroxin (t4) on fetal lung maturity was investigated by means of selective dpl determination. following administration of thyroxin to the mother animal an increase in the dppc content was demonstrated in rat fetuses. this increase was greater than that of the total phospholipids. this effect of thyroxin could be due t ...	1982	6896943