Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| preliminary study on the effect of temperature on the transport of thyroxine (t4) into the body tissues and sub-cellular fractions of liver and muscle of carp, cyprinus carpio. | in order to determine if the inability of thyroxine to induce cellular effects at low temperature is mediated through a temperature-sensitive system for the translocation of t4 into the nucleus, the effect of temperature on the uptake of t4 by body tissues and sub-cellular fractions of carp liver and muscle was studied in vivo. a single injection of 125i-t4 (1 micro c/10 g body weight) was given intraperitoneally to juvenile carp maintained at 15 and 25 c. uptake from the peritoneal cavity was r ... | 1983 | 6670568 |
| ipsilateral thyroid growth and depressed thyroid hormone synthesis and content after unilateral superior cervical ganglionectomy in rats. | the role of the sympathetic nervous system in the control of the goitrogenic response was examined in adult male rats subjected to unilateral superior cervical ganglionectomy 12-30 days earlier. a spontaneous goiter as well as an increased thyroid growth after the administration of the goitrogenic agents methylmercaptoimidazole and thyrotropic stimulating hormone (tsh) were found in the ipsilateral lobe. norepinephrine and epinephrine content decreased significantly by 80 and 31%, and thyroxine ... | 1983 | 6670569 |
| study of the pituitary-thyroid axis in euthyroid goiter after partial thyroidectomy. | the aim of this study was to investigate the time involved after hemithyroidectomy in reaching a new steady state in thyroid function and the relationship between thyroid hormones, basal tsh levels and tsh response to trh. the investigations were performed on 35 patients 12-18 months after partial thyroidectomy in the first investigation and after 24-30 months in the second investigation. tests included t4, t3, ft4, ft3 serum levels, basal serum tsh and tsh response to trh. none of the patients ... | 1983 | 6672072 |
| hypothyroidism and antibody production in immature male chickens. | this study was conducted to determine if hypothyroidism has an effect on humoral immunity in immature male chickens. two week old single comb white leghorn male chicks were used as experimental animals. two experiments were conducted using different methods to induce hypothyroidism. in experiment 1, birds were surgically thyroidectomized (tx group) and in experiment 2, hypothyroidism was induced by supplementing the feed throughout the experiment with 0.1% propylthiouracil (ptu group). antibody ... | 1983 | 6674126 |
| age-related alterations in thyroid hormone binding properties of porcine skeletal muscle cytosol. | thyroid hormone binding properties were evaluated in cytosol prepared from semitendinosus muscle of 1-d, 3-wk and 5-mo-old yorkshire-duroc crossbred pigs. optimum thyroxine (t4) binding was obtained with 35 ug cytosolic protein in a solution containing 50 mm tris-hcl buffer, ph 7.4, and 25 mm kcl and 10 mm mgcl2. the half-time of maximum t4 binding was approximately 10 min. protease digestion of cytosol eliminated specific t4 binding. muscle cytosol preferentially bound t4 over triiodothyronine ... | 1983 | 6674284 |
| [experimental studies of gammacoat t3 and t4 ria kit]. | 1983 | 6675054 | |
| bacteriophage concentration from water by filter chromatography. | the efficiency of an electropositive filter for membrane chromatography of viruses was examined using coliform phages t1, t4, lambda and salmonella phage p22. phages diluted in dechlorinated tap water were adsorbed to filters at neutral ph and eluted by 3% beef extract in 0.05 m glycine buffer at selected alkaline ph values. with exception of lambda phage, which displayed erratic adsorption behavior at any ph, all bacteriophages studied, adsorbed to filters with an efficiency of 97-100% at ph va ... | 1983 | 6677647 |
| t4 levels in methylxanthine-treated premature newborns. | the respiratory stimulants caffeine and theophylline are able to control apneic spells in premature newborns. however both substances have goitrogenic properties in rats on low-iodine diet. they lower t4 serum levels and inhibit tsh- and gh-release probably by enhancing hypothalamic somatostatin secretion. the retrospective study described here was carried out in an attempt to clarify whether treatment of premature children with methylxanthines has adverse effects on thyroid function. the result ... | 1983 | 6677876 |
| effects of indomethacin on thyroid iodine metabolism. | several alterations of thyroid function parameters have been reported in animals treated with indomethacin, and we have studied the effect of this drug on the intrathyroidal iodine metabolism in wistar rats. indomethacin was administered by an esophagic tube in two doses (total = 6 mg) given at 0 and 5 hours in experiment i and three doses (total = 9 mg) given at 0, 10 and 23 hours in experiment ii. no significant differences in thyroid weight, thyroidal 131i uptake and (131i) iodoaminoacids dis ... | 1983 | 6678104 |
| [clinical importance of the level of the free fraction of thyroid hormones]. | the physiologic importance of the free fraction of thyroid hormones is well accepted for some time. the determination of free thyroid hormones plasma levels by column chromatography and radio-immunoassays has been tested in our laboratory since november 1980. six hundred and ten patients have been submitted to a precise anamnesis, a clinical examination and a thyroid investigation by scintigraphy and echography. we have compared the following parameters: t4 and ft4, t3 and ft3, tsh, tbg in euthy ... | 1983 | 6678144 |
| radioimmunoassay of triiodothyronine (t3) and thyroxine (t4). an assay with both the bound and free fraction of the hormone present in the counting vessel. | a radioimmunoassay for triiodothyronine t3 and thyroxine t4 without any manual separation is described. by the use of an aqueous two-phase system the free hormone was separated from the immunologically bound fraction and lifted out of the counting area of the gamma counter. the coefficient of correlation between results obtained with this method and with a conventional ria was 0.97 and 0.93 for t3 and t4, respectively. | 1983 | 6679187 |
| [enzymatic synthesis of oligonucleotides corresponding to the 3'-terminus of influenza virus rna]. | dodecanucleotide cpcpupgpcpupupupupgpcpu corresponding to 3'-terminus of influenza virus rna has been synthesized. the initial blocks cpcpu, gpcpu, pgpcpu and pgpcpup were prepared enzymatically in the presence of ribonucleases of different substrate specificity and polynucleotide phosphorylase m. luteus. pupupu was obtained by enzymatic degradation of polyuridilic acid. the initial blocks were joined by t4 rna-ligase. | 1983 | 6679759 |
| the different clinical presentation, behaviour and prognosis of carcinomas originating in the epilarynx and the lower supraglottis. | within the supraglottic larynx, two subregions can be distinguished: the epilarynx and the lower supraglottis. tumours arising in these structures have very different clinical presentations and prognosis. management should be adjusted accordingly. between 1962 and 1977, 325 patients with supraglottic cancer were seen, of whom 317 presented as untreated cases. in 171 patients (54%) the tumour originated in the lower part of the supraglottis. in this group 61% had t1 or t2 lesions, 23% had palpabl ... | 1983 | 6680217 |
| [neonatal screening for congenital hypothyroidism. experience at a regional center]. | we examined 107,670 infants born in the italian region emilia-romagna. capillary blood samples for contemporary t4 and tsh radioimmunoassay were collected on the 3rd, 4th, 5th, 6th, 7th or between the 7th and the 15th day of life on filter paper. in our method the threshold value for recall for a second assay was calculated taking into account the mean - 2 sd of each session for t4, and fixing between 30 and 50 microu/ml the threshold value for tsh. the re-call percentage was 0.74%. 21 subjects ... | 1983 | 6681053 |
| [hormonal therapy of congenital hypothyroidism in childhood]. | l-tiroxine (l-t4) substitutive therapy has been evaluated in a group of 15 hypothyroid children (6 males and 9 females), one to six years old. we have found a wide dosage range, being not possible to find any significant difference between ranges leading to normal and ranges leading to pathological findings, thus making impossible to suggest a reasonably safe dosage pro kg. of body weight. increasing l-t4 dosage we have got a significant increase of ft4 levels, a significant decrease of tsh leve ... | 1983 | 6681055 |
| influence of age, strain and season on diurnal periodicity of thyroid stimulating hormone, thyroxine, triiodothyronine and parathyroid hormone in the serum of male laboratory rats. | the influence of age, strain and season on the diurnal pattern of serum hormone levels from the pituitary-thyro-parathyroid complex was studied in male laboratory rats. distinct 24 h periodicity in the serum levels of thyroid stimulating hormone (tsh) and triiodothyronine (t3) was observed in all groups of rats. there was no influence of age (40, 60 and 90 days old sprague-dawley rats), but a significant influence of strain (sprague-dawley vs. bh/ztm rats) and season (summer vs. winter) on the d ... | 1983 | 6681926 |
| [therapy of an advanced tumor of the upper jaw (case report)]. | the authors present a t4 tumor situated on the left side of the upper jaw and showing an extraordinary development. it was a partially keratinizing squamous cell carcinoma which broke into the middle base of the skull and penetrated into the brain. by combined radiotherapy and chemotherapy, partly with 60co gamma radiation, partly with photon and electron beams, a surgical treatment of the extensive primary tumor became possible. the formation of metastases within the lymph nodes of the neck was ... | 1983 | 6682256 |
| thyroid-stimulating hormone: response test in healthy horses, and effect of phenylbutazone on equine thyroid hormones. | adult horses showed a mild diurnal variation in equine plasma thyroxine (t4) concentrations, but not triiodothyronine (t3). plasma t4 concentrations tended to be higher between 5 pm and 8 pm than at 8 am. increases in plasma t4 and t3 were similar in adult healthy horses given 5, 10, or 20 iu of thyroid-stimulating hormone (tsh). the t4 peaked at approximately twice (2.0 +/- 0.4 times) as high as the base line at 6 to 12 hours after the tsh was given. the greatest change from base line t3 occurr ... | 1983 | 6682298 |
| [radio-in-vitro studies of the thyroid status of mature newborn infants immediately post partum]. | 145 cord sera from fullterm, vital eutrophic newborn babies of uncomplicated pregnancies have been tested for the thyroid gland parameters rt3-u, st3-u, t4, t3, t4/t3-ratio, total balance of free iodine-hormone indices and tsh to answer the questions of the thyroid gland situation. in the fullterm newborn baby an euthyroid metabolic balance was found on comparison with the simultaneously determined thyroid specific situation of the adult. the t3-situation is identical with that of the euthyroid ... | 1983 | 6682602 |
| thyrotoxicosis in pregnancy: results of treatment by antithyroid drugs combined with t4. | treatment of thyrotoxicosis in pregnancy with antithyroid drugs plus supplementary t4 is controversial. data are presented on twenty consecutive pregnancies treated by this method. the mean birth weights of the babies and their gestation did not differ from those of normal controls. cord blood mean t4 and free t4 index (ft4i) were not significantly different from controls and total t3 and free t3 index (ft3i), though significantly lower than the controls, were all within the normal range. in fiv ... | 1983 | 6682725 |
| the effect of iodine containing contrast medium on thyroid function of patients undergoing coronary angiography. | application of large amounts of iodine in the form of amidotricoic acid (urografin) in 20 patients undergoing coronary angiography led to an increase in serum thyroxine (t4, p less than 0.005), triiodothyronine (t3, p less than 0.005) and plasma thyrotropin (tsh) in the basal state (p less than 0.05) as well as after trh-stimulation (p less than 0.05), but not of serum 3,3',5'-triiodothyronine (reverse-t3, rt3) three weeks after contrast medium administration. although trh induced tsh stimulatio ... | 1983 | 6682783 |
| mild hypothyroidism and oedema: evidence for increased capillary permeability to protein. | nine female patients with normal serum total thyroxine (t4) and triiodothyronine (t3) but elevated thyroid stimulating hormone (tsh) levels were studied. six patients had generalised oedema associated with maximal diurnal weight gains in excess of 1.4 kg. under conditions of forced water diuresis, before and during physiological replacement of 1-thyroxine, the supine transcapillary escape rate of albumin (tera) was measured, while the venous colloid osmotic pressure (cop), packed cell volume (pc ... | 1983 | 6684003 |
| effects of propylthiouracil, methimazole and thyroidectomy on liver and plasma proteins: differential response to thyroxine. | differential effects of propylthiouracil (ptu), methimazole (mmi) and thyroidectomy (tx) on liver and plasma proteins have been studied in rats, some of which have been simultaneously treated with l-thyroxine (t4). although the absolute liver weights were lower in all hypothyroid groups, the relative liver weights (g/100 g) were significantly higher in ptu and mmi groups, while in tx group they were lower. t4 administration raised the absolute liver weights in all groups, even though there was n ... | 1983 | 6684061 |
| foetal head growth retardation due to antiepileptic drugs: with reference to gh, tsh, t4, t3 and reverse t3 concentrations. | to study the mechanisms of inhibitory action of antiepileptic drugs on foetal head growth, determinations were made of the growth hormone, thyrotropin and thyroid hormone levels in the sera of pregnant women, and the correlations between each hormone concentration and the foetal head circumference were studied. the thyroxine level decreased in the maternal serum and in the cord blood, and the thyrotropin level also became lower in the epileptic mother taking antiepileptic drugs. the growth hormo ... | 1983 | 6684085 |
| endogenous cortisol and thyroid hormone levels in patients with acute myocardial infarction. | thyroid hormones and cortisol levels were serially measured over seven mornings and evenings in 23 consecutive patients with acute myocardial infarction (ami) or acute coronary insufficiency (aci). the patients were divided into two groups, high level cortisol (hlc) and low level cortisol (llc) groups, according to mean morning and evening cortisol levels. the transient increase in plasma rt3, decrease in t3 and tsh was significantly greater in the hlc group. a diurnal variation in cortisol leve ... | 1983 | 6684511 |
| pituitary-thyroid function during acute immobilization stress in rats. | in nine experiments a total of 394 male wistar rats weighing about 300 g was used. in each experiment, one intact control group was used and several other groups were subjected to immobilization (imo) for 2 to 240 min in a prone position by inserting their heads through steel wire loops fixed on a board and by fasting their limbs to four metal strips by adhesive tape. all animals were killed by decapitation and the levels of thyrotropin (tsh), thyroxine (t4), 3,5,3'-triiodothyronine (t3) and 3,3 ... | 1983 | 6684585 |
| [transmission of amber mutants in bacteriophage t4. ii. thermal sensitivity of the multiplication of gene 26 amber mutants in escherichia coli b cells and the absence of such sensitivity in the case of gene 33]. | the dependence of multiplication of genes 26 and 33 amber mutants of t4d phage in a non-permissive host on the temperature in the range of 25-41 degrees c has been studied. the secondary mutations observed in the genome of gene 26 mutants ams105 and amng114 were excluded by crossing these mutants with the wild type phage. it was established that multiplication of gene 26 amber mutants ams105x5, amn131 and amng114x1 depends, essentially, on the temperature: the burst size of phage gradually decre ... | 1983 | 6684608 |
| differential effects of propylthiouracil, methimazole and thyroidectomy on liver ferritin. | different groups of rats were made hypothyroid by thyroidectomy (tx) or treatment with propylthiouracil (ptu) or methimazole (mmi). some of the hypothyroid rats from each group were simultaneously treated with thyroxine (t4). liver ferritin concentration and 14c-glycine incorporation into liver ferritin in these rats were studied. only in mmi-treated rats the ferritin concentration was elevated, which was reduced by simultaneous t4 treatment. ptu treatment resulted in 36-42% reduction in ferriti ... | 1983 | 6685048 |
| planned preoperative cisplatin and radiation therapy for locally advanced bladder cancer. | cisplatin (ddp) is an active agent in the treatment of disseminated bladder cancer. in addition to its direct tumor cytotoxicity, recent animal and clinical data suggest synergism with radiation therapy (rt). since improved survival with preoperative rt is largely restricted to bladder cancer patients in whom radiation-induced downstaging (p less than t) may be recognized, the authors administered ddp + rt preoperatively to patients with locally advanced (t3, t4) bladder tumors selected for cyst ... | 1983 | 6685567 |
| antihormonal effects of plant extracts. pharmacodynamic effects of lithospermum officinale on the thyroid gland of rats; comparison with the effects of iodide. | the antithyrotropic activity of freeze-dried-extracts from lithospermum officinale (lith. off. fde) was investigated in the rat. when administered together with tsh, lith. off. fde blocked the tsh-induced increase in endocytotic activity of the thyroid glands followed by a strong decline of thyroid hormone levels. furthermore, when lith. off. fde was injected alone it caused a decline in endogenous tsh-levels as well as in thyroidal secretion and thyroid hormone levels. the efficacy of the extra ... | 1983 | 6685685 |
| the effect of repeated administration of l-thyroxine on the activity of certain enzymes in the blood plasma of hens. | studies on the influence of long-lasting hyperthyroidism on enzyme activities and total protein level in the blood plasma of adult leghorn hens showed that: 1. protein level during whole experimental period showed inconsiderable variability irrespective of t4 dose. 2. activity of aspartate aminotransferase (got) and alanine aminotransferase (gpt) increased. changes were dependent on t4 dosage level. 3. t4 had no effect on activity of aldolase. | 1983 | 6686147 |
| [is there any progress in the treatment of squamous epithelial carcinoma of the oropharynx?]. | the treatment of squamous cell carcinomas of the oropharynx still remains a problem because of the high rate of recurrence and the functional importance of the oropharynx in speech and swallowing. although the technique of reconstruction after radical resection of the tumour has been considerably improved by the introduction of the pectoralis major myocutaneous flap, the need for an alternative treatment is evident in those patients with advanced tumours (t3/t4) and/or with a high risk in connec ... | 1983 | 6686989 |
| multimodal treatment of locoregionally advanced breast cancer. | fifty-two patients with locally advanced primary breast cancer (t3, t4/n2, n3) without distant metastases were treated with three cycles of combination chemotherapy consisting of 5-fu, adriamycin and cyclophosphamide (fac) and immunotherapy with bacillus calmette-guerin (bcg) followed by local therapy (simple mastectomy and/or radiotherapy to breast/chest wall and regional lymphatics) and adjuvant chemotherapy to complete two years of treatment. forty-nine of 52 (94%) patients were rendered free ... | 1983 | 6687377 |
| serum free thyroid hormones in t3-toxicosis: a study of 35 patients. | few data are available on serum free thyroid hormone concentration in patients with t3-toxicosis. in this study total and free t4 and t3 and tbg were evaluated in 35 subjects with t3-toxicosis, including 12 with untreated graves' disease, 5 graves' patients on methimazole treatment, 13 with autonomous adenoma, 3 with multinodular goiter, and 2 with subacute thyroiditis. t4, t3, free t4 (ft4), free t3 (ft3) as well as calculated t4/tbg and t3/tbg ratios were significantly higher in patients than ... | 1983 | 6687730 |
| recovery of thyroid function with a decreased titre of antimicrosomal antibody in a hypothyroid man with hashimoto's thyroiditis. | a 36 year old man with a diffuse goitre, signs of mild hypothyroidism, strikingly low levels of t4 (0.9 micrograms/dl) and t3 (24 ng/dl), elevated tsh (140 microu/ml) and elevated microsomal haemagglutination antibody (mcha, 1:409 600), subsequently became non-goitrous and euthyroid with a decreased titre of antimicrosomal antibody without any medication. at the time of surgical biopsy, serum levels of t4 and t3 had risen to the normal range (4.6 micrograms/dl and 73 ng/dl, respectively), serum ... | 1983 | 6687775 |
| intrathyroidal concentrations of methimazole in patients with graves' disease. | a sensitive gas chromatographic-mass spectrometric method enabled us to study intrathyroidal concentrations of methimazole in 20 euthyroid patients with graves' disease on treatment with carbimazole and t4. there was no difference between patients receiving a final dose of carbimazole (10 mg), known to be totally bioactivated to methimazole (6.1 mg), 3-6 h before thyroid excision (518 ng/g thyroid tissue +/- 90 sem) and patients who received the same dose 17-20 h before excision (727 ng/g thyroi ... | 1983 | 6687892 |
| immunohistologic and immunoelectron microscopic characterization of the mucosal lymphocytes of human small intestine by the use of monoclonal antibodies. | monoclonal antibodies reactive with t cells, t cell subsets, b cells, monocytes, and natural killer cells were used to characterize the nature of mucosal lymphocytes in the human small intestine by application of the immunoperoxidase technique to tissue sections for light and electron microscopic examination. in addition, for comparison, peripheral blood mononuclear cells (pbl) were studied by immunoelectron microscopy. most of the intraepithelial lymphocytes (iel) were t cells (leu-1+, t3+) and ... | 1983 | 6687894 |
| use of adjunctive potassium iodide after radioactive iodine (131i) treatment of graves' hyperthyroidism. | one hundred and nineteen patients with graves' hyperthyroidism who were treated with 131i alone or 131i followed by potassium iodide (131i + ki) were studied retrospectively. patients in both groups who required only a single dose of 131i for successful treatment of hyperthyroidism had similar age, gland size, 24-h radioactive iodine uptake, pretreatment serum t4 concentrations, and radioactive iodine treatment dose. seven weeks after 131i, mean serum t4 concentrations were 12.3 +/- 6.1 microgra ... | 1983 | 6688081 |
| [in vitro diagnosis of t3 thyrotoxicosis]. | a study was made of the importance of various radioimmunoassays and their reliability in the diagnosis of functional activity of the thyroid parenchyma in patients with nodular goiter. a total of 298 patients were examined, of them 172 with nodular toxic goiter and 116 with nodular euthyroid goiter. during scanning the most frequent variant of nodular goiter was a "warm" or "hot" node, then a "cold" and "autonomous" one. to define the effect of the globulin thyroxine binding ability on the level ... | 1983 | 6688114 |
| rapid improvement of thyroid function by using glucocorticoid indicated for the preoperative preparation of subtotal thyroidectomy in graves' disease. | glucocorticoid therapy is not considered as an authentic method for obtaining euthyroid in graves' disease. we tried the administration of prednisolone as a preoperative preparation for subtotal thyroidectomy in 4 hyperthyroid patients with graves' disease who had suffered adverse effects of thionamide antithyroid drugs, including agranulocytosis, liver damage and skin eruptions. following oral administration of a 30 mg daily dose of prednisolone, with or without other antithyroid reagents, both ... | 1983 | 6688394 |
| a prospective study of the relationship between relapse of hyperthyroid graves' disease after antithyroid drugs and hla haplotype. | one hundred and eleven unselected patients with hyperthyroidism due to graves' disease received decreasing doses of carbimazole for 18 months. clinical examination and hormonal assays (serum t3, t4, free t4 index) were done at 4, 9, and 18 months of treatment. patients were typed for 35 hla antigens and were followed for 2 yr after withdrawal of treatment; 39 patients were excluded for various reasons and 72 were retained for study. of the 72 patients, 37 relapsed and 35 remained in remission; 4 ... | 1983 | 6688428 |
| [2 cases of hashitoxicosis with histological features of adenomatous goiter]. | two male patients with 'hashitoxicosis', who revealed histologic pictures of adenomatous goiter in addition to findings of chronic thyroiditis, are described. case 1. a 55-year-old man was admitted on may 7, 1981, for evaluation of hyperthyroidism. he had exophthalmos with positive moebius and von graefe's signs, and a firm, asymmetrically enlarged non tender thyroid gland with multiple cysts. the bmr was +60%, t4 26.4 micrograms/dl, free t4 7.2 ng/dl, t3 5.62 ng/ml and 24 hr radioiodine uptake ... | 1983 | 6688593 |
| [clinical evaluation of routinely applied highly sensitive tsh-ria]. | forty-one routine tsh assays were carried out by applying newly developed, highly sensitive tsh ria (t. mori, et al., folia endocrinol. jap., 56: 1231, 1980). b/b0 percent of the least standard point (0.156 microu/ml) was consistently lower than b0 and higher than that of 0.31 microu/ml. the distributions of assayed tsh concentrations in 1394 sera revealed that 34.8% of the total were in an undetectable range when measured by conventional method (less than 1.0 microu/ml), but this method picked ... | 1983 | 6688785 |
| [studies on anti-t3 and anti-t4 autoantibodies found in 2 sisters with juvenile hypothyroidism due to hashimoto's thyroiditis. iii. anti-rt3 autoantibodies]. | we previously reported that two sisters with juvenile hypothyroidism due to hashimoto's thyroiditis (case 1: 13 years old, case 2: 10 years old) had antibodies against t3 and t4, and that the titers of these antibodies decreased but remained above normal levels even in the euthyroid state during l-t4 treatment. in our further investigations we found the binding of 125i-rt3 to serum gamma-globulin in both cases in the pre-treatment period. this binding was completely inhibited by the addition of ... | 1983 | 6688786 |
| effect of the combination of dexamethasone and sodium ipodate on serum thyroid hormones in graves' disease. | to investigate the effect of the combination of dexamethasone (dex) and sodium ipodate (si) on hyperthyroidism, we studied 24 patients with typical graves' disease, divided into four groups of six persons each. three groups (study i) were studied acutely (24 h) to determine the effects of dex (5 mg every 12 h intramuscularly), si (one oral dose of 3 g) and both drugs at the same doses, upon t4, t3, and rt3 at 0900 h before therapy was started and 24 h later. the group on dex and that on si had a ... | 1983 | 6688973 |
| [thyroid hormone autoantibodies in hashimoto's disease and graves' disease]. | we previously reported the presence of thyroid hormone autoantibodies (thaa) in the sera from three (2 hashimoto's thyroiditis, 1 hashimoto's thyroiditis suspected) out of four sisters in a family and one patient with graves' disease during treatment with methimazole (mmi). according to the investigations of the binding of labelled thyroid hormones, endogenous and/or therapeutic thyroid hormones interfered with their binding with thaa. this interference, however, was excluded when the sera were ... | 1983 | 6689304 |
| attention disturbance in graves' disease. | twenty-seven patients with untreated graves' disease were studied in order to determine alterations of concentration/attention and their possible association with levels of t4, t3ru, free thyroxin index (fti), and anxiety. the patients obtained significantly lower values (p less than 0.01) throughout the whole application period of the concentration/attention test in comparison with control healthy group. multiple regression equations relating the attention indexes with levels of t4 and t3ru, ft ... | 1983 | 6689536 |
| thyroid storm--a nursing crisis. | a 48-year-old woman with a known history of hypothyroidism was admitted to the intensive care unit with a diagnosis of thyroid storm secondary to acute thyroid hormone poisoning and the possible hyperfunction of a singular thyroid nodule. her clinical manifestations included pyrexia, tachycardia, tachypnea, hypertension, ruq abdominal pain, psychotic behavior, and pharyngitis. she was successfully treated with sodium iodide, ptu, propranolol, antibiotics, and a hypothermia mattress, with her ser ... | 1983 | 6550051 |
| separation and radioimmunoassay of t3 and t4 in human breast milk. | there is little agreement among published reports of the radioimmunoassayable thyroid hormone content of breast milk, likely due to wide variations in methodology applied. in order to achieve a higher degree of specificity in the determination of t3 and t4 concentrations in breast milk, samples were ethanol-extracted and then chromatographed on an lh-20 column. using this method, all t3 and t4 ria activity eluted with the void volume. following pancreatin digestion and subsequent extraction of w ... | 1983 | 6551313 |
| total synthesis of yeast alanine transfer ribonucleic acid. | by a combination of chemical and enzymatic methods, small oligonucleotides with lengths varying from 2 to 8 nucleotides were synthesized from mononucleotides. the small oligonucleotides were then ligated with t4 rna ligase into six large oligonucleotides (9 to 19 nucleotides long) which were further ligated to form two half molecules with 35 and 41 nucleotides respectively. finally, the two synthetic half molecules were annealed and ligated to obtain the whole molecule of yeast alanine trna (trn ... | 1983 | 6553356 |
| synthesis of the 3'-half molecule of yeast alanine trna. | this paper deals with the synthesis of the 3'-half molecule of yeast alanine transfer rna (trnaalay) by ligation with t4 rna ligase of three component oligonucleotide fragments corresponding to nucleotides 36-45(i), 46-57(ii) and 58-76(iii) in succession extending from the 3'-end to the 5'-end. first, in a ratio of acceptor to donor at 1.5 to 1, we adopted a method of three successive reactions, namely, the 5'-phosphorylation of the nonadecamer (iii), ligation with the dodecamer (ii) and the 5'- ... | 1983 | 6553357 |
| synthesis of the 5'-half molecule of yeast alanine trna. | in this paper, we report the synthesis of the 5'-half molecule of yeast alanine trna (trnaalay) by ligating three oligonucleotide fragments corresponding to the nucleotide sequences 1-13, 14-22 and 23-35 respectively under the catalysis of t4 rna ligase (fig. 1). because of the high purity of the oligonucleotide fragments and the excellent quality of t4rna ligase and polynucleotide kinase we prepared, the isolation steps were simplified and the overall yields were much higher. the ligating yield ... | 1983 | 6553358 |
| blockade of the preovulatory release of gonadotropins and prolactin by spinal transections in female rats. | the effect of spinal transections on the preovulatory release of gonadotropins and prl was investigated in female rats. a preovulatory rise in serum lh, fsh and prl and subsequent ovulation were prevented by complete spinal transections (cst) at high thoracic levels (t3-t7), but not at low thoracic and lumbar levels (t8-l5), performed at 1000-1230 h on proestrus. norepinephrine (ne) concentrations in the preoptic-anterior hypothalamic area at 1700-1800 h on proestrus were also significantly redu ... | 1983 | 6420140 |
| [pituitary-thyroid function in patients with cushing's syndrome--comparative study before and after extirpation of adrenal cortex tumor]. | the pituitary-thyroid function and the metabolism of the thyroid hormones in the blood were investigated in 19 patients with cushing's syndrome before and after an adrenalectomy, 16 patients had adrenal adenomas and 3 patients had modular adrenal hyperplasias. serum t4, free t4 (ft4), t3, reverse t3 (rt3), tbg and tsh were measured in all patients by radioimmunoassay, and changes in serum tsh, prl and hgh following the injection of trh 500 micrograms in 10 out of 19 patients were observed to eva ... | 1983 | 6420208 |
| [usefulness of the trh-t3 test in the diagnosis of central hypothyroidism]. | trh tests (500 micrograms, i.v. bolus) were performed in 15 patients with various hypothalamic or pituitary disorders and in 6 control subjects. tsh (highly sensitive ria) and t3 were measured before and 30, 60, 90 and 120 min. after trh. in 8 out of 15 patients, low circulating thyroid hormone levels were observed, but their basal tsh levels were all in the normal range or even higher (0.8 - 5.5 microu/ml). further, their integrated tsh responses (38 +/- 21 microu/ml) did not differ significant ... | 1983 | 6420209 |
| roles of poly(adp-ribose) synthesis in repair and replication in normal human, cockayne syndrome, and xeroderma pigmentosum fibroblasts after uv irradiation. | roles of poly(adp-ribose) in repair and replication were studied in uv-irradiated normal, xeroderma pigmentosum (xp), and cockayne syndrome (cs) fibroblasts. uv radiation reduced cellular nad with concurrent synthesis of poly-(adp-ribose) in a dose-dependent manner in normal and cs cells, but not in xp cells. enzymatic incision of dna of uv-irradiated xp cells by t4-endonuclease v activated poly(adp-ribose) polymerase. methyl methanesulfonate (mms) also reduced the cellular nad in all the above ... | 1983 | 6418714 |
| effects of trh injection on hippocampal-hypothalamic-pituitary-thyroid interactions. | the first experiment was conducted in an attempt to ascertain the effects of hippocampal lesions on plasma levels of total t4, total t3, free t4, and tsh. animals with hippocampal lesions had significantly lower levels of total t4, free t4 and tsh than cortical control and normal animals. there were no significant differences in total t3 among the three groups. since these results indicated that animals with hippocampal lesions manifested a dysfunction in the hypothalamic-pituitary-thyroid axis, ... | 1983 | 6419209 |
| beta-neoendorphin inhibits thyrotrophin secretion in rats. | the effects of beta-neoendorphin on thyrotrophin-releasing hormone (trh) and thyrotrophin (tsh) secretion in rats were studied. beta-neoendorphin (500 micrograms/kg) was injected iv, and the rats were decapitated serially. trh, tsh, thyroxine (t4) and 3,3',5-triiodothyronine (t3) were measured by means of a specific radioimmunoassay for each. hypothalamic immunoreactive trh (ir-trh) content increased significantly after beta-neoendorphin injection, and plasma concentrations tended to decrease, b ... | 1983 | 6419521 |
| effects of thymopoietin pentapeptide (tp-5) on in vitro and in vivo ige production by atopic dermatitis cell subsets. | atopic dermatitis (ad) patients exhibit multiple immune abnormalities, including t-cell defects that may be partially correctable by the administration of thymic hormones. our investigations confirmed that peripheral blood mononuclear leukocytes obtained from patients with ad spontaneously synthesized markedly elevated amounts of ige in vitro. the thymic hormone thymopoietin pentapeptide (tp-5) greatly inhibited this synthesis. an antihuman pan-t cell monoclonal antibody (lyt3) was used to separ ... | 1983 | 6388971 |
| lymphocyte subpopulations in kawasaki disease. | the relative percentages of subpopulations of peripheral t lymphocytes in children with kawasaki disease (kd) was investigated using matched antibodies directed against the t3, t4 and t8 antigens. the percentage of b cells was determined with antibodies against human surface immunoglobulins. subjects were six children with acute kd who were compared to normal, age matched controls. the percentage of peripheral lymphocytes positive for okt3 was 61% for kd children and 64% for controls; for okt4 t ... | 1983 | 6398155 |
| [primary structure of the elongation factor g from escherichia coli. vi. structure of peptides of cyanogen bromide cleavage of the g-factor molecule]. | peptides obtained as a result of cyanogen bromide cleavage of the g-factor have been studied. all 12 peptides embracing the whole structure of fragment t4 have been isolated. for their amino acid sequence determination, cyanogen bromide peptides have been further cleaved with trypsin, chymotrypsin, thermolysin, staphylococcal glutamic protease and bnps-skatole. the complete primary structure of 9 from 12 cyanogen bromide peptides has been determined. | 1983 | 6385997 |
| [primary structure of the elongation factor g from escherichia coli. vii. study of peptides generated during hydrolysis of the t4 fragment by glutamic proteinase from staphylococcus aureus]. | for fragment t4, obtained on limited trypsinolysis of the g-factor, the amino acid sequence embracing 76% of its structure has been determined by analysis of peptides resulting from the fragment t4 cleavage with staphylococcal glutamic protease. these data permitted to assemble into one polypeptide chain 7 out of 12 earlier characterized cyanogen bromide peptides contained in the fragment t4. | 1983 | 6385998 |
| [primary structure of the elongation factor g from escherichia coli. viii. structure of tryptic peptides comprising the t4 fragment of limited trypsinolysis of the g-factor]. | products of tryptic hydrolysis of the maleic anhydride modified fragment th3 from limited thermolytic hydrolysis of the g-factor have been studied. some short peptides which result from the trypsin action on the native g-factor molecule and belong to the fragment t4 obtained on limited trypsinolysis of the g-factor have been separated and their structure has been studied. as a result amino acid sequence has been determined by tryptic peptides containing 322 amino acid residues of the fragment t4 ... | 1983 | 6385999 |
| t3b-t4 breast cancer: factors affecting results in combined modality treatments. | two hundred and seventy-seven consecutive patients with t3b-t4 breast cancer referred to the milan cancer institute between 1973 and 1980 were treated with a combined modality approach. chemotherapy (ct) consisted of av, i.e. adriamycin (60-75 mg/m2 day 1) and vincristine (1.2 mg/m2 days 1 and 8) and was given for three to four cycles prior to local regional modality. local-regional treatment consisted of either radiotherapy (rt) in 198 patients or surgery (s) in 79 women. additional chemotherap ... | 1983 | 6400435 |
| diabetes mellitus and thyroid disease. | diabetes mellitus not infrequently coexists with hypo- and hyperthyroidism. hyperthyroidism aggravates glucose intolerance. a review of this phenomenon reveals multiple mechanisms, which include increased hexose intestinal absorption, decreased responsiveness to insulin, and increased glucose production. conflicting results are obtained when circulating insulin level is measured in thyrotoxicosis. the role of glucagon and alpha-cell sensitivity is unclear. diabetes mellitus influences the assess ... | 1983 | 6400713 |
| on the processivity of dna replication. | in this paper we describe the nature and importance of processive enzymatic reactions in biological processes. a model is set up to describe the processive synthetic process in dna replication, and experiments are presented to define and test the model, using the components of the t4 phage-coded five-protein (in vitro) dna replication system of alberts. nossal and coworkers. these experiments are performed either with a homogeneous oligo dt-poly da primer-template system, or with a natural prime ... | 1983 | 6400896 |
| the interactions of enzyme and chemical probes with inverted repeats in supercoiled dna. | in negatively supercoiled dna molecules some inverted repeat sequences adopt a perturbed conformation which is characterised by the following properties. they are centrally hypersensitive to single-strand-specific nucleases such as s1, and to a much lower extent the flanking regions may also be sensitive. they are also hypersensitive to modification by bromoacetaldehyde, particularly in their flanking region. they may be resistant to endonucleolysis by restriction enzymes and are cleaved (resolv ... | 1983 | 6401110 |
| evidence of a thyrotropin-releasing hormone-dependent increase in plasma thyrotropin during refeeding of starved rats. | after 3 days of starvation, refeeding with carbohydrate (cho) leads to a rapid increase in plasma t4 and t3, suggesting increased tsh secretion. the aim of the present study was to describe the time course of plasma tsh changes during refeeding with cho and fat. repetitive blood samples were obtained from freely moving animals by indwelling jugular venous catheters. refeeding was performed on the fourth day of starvation at either 1100 or 1900 h, and blood was sampled during the preceding hour a ... | 1983 | 6401245 |
| effect of albumin concentration on the assay of serum free thyroxin by equilibrium radioimmunoassay with labeled thyroxin analog (amerlex free t4). | serum free thyroxin (ft4) in normal nonpregnant and pregnant subjects was measured by radioimmunoassay (ria) with amerlex ft4 ria (amersham international) and liquisol ft4 ria (damon diagnostics) kits. amerlex ft4 values in serum from pregnant women were lower than those in serum from nonpregnant women, but liquisol ft4 values were similar in serum from both groups. amerlex ft4 values were directly correlated with the concentrations of albumin in serum and inversely correlated with those of thyr ... | 1983 | 6401605 |
| [oral trh stimulation in patients with thyroid carcinoma]. | in patients with differentiated thyroid carcinoma high serum tsh-levels enhance 131 j-uptake in thyroid remnant and/or metastases. an effective increase of tsh could be achieved by oral administration of thyrotropin releasing hormone (trh) even after a short t4/t3-withdrawal period so that we recommend a trh-stimulation in all patients before a diagnostic or therapeutic 131 j-application. adverse reactions to trh are infrequent and usually short timed so that in contrast to tsh-stimulation--trh ... | 1983 | 6401667 |
| simultaneous turnover studies of thyroxine, 3,5,3' and 3,3',5'-triiodothyronine, 3,5-, 3,3'-, and 3',5'- diiodothyronine, and 3'-monoiodothyronine in chronic renal failure. | the present study evaluates the sequential extra-thyroidal monodeiodination of thyroid hormones through tri-, di-, and monoiodothyronines in chronic renal failure (crf) in man. simultaneous turnover studies of t4, t3, rt3, 3,5-diiodothyronine (3,5-t2), 3,3'-t2, 3',5'-t2, 3'5'-t2, and 3'-monoiodothyronine (3--t1) were conducted in six patients with crf (creatinine clearance, 9-18 ml/min) using the single-injection, noncompartmental approach. serum levels of t4, t3, and 3,5-t2 were reduced to two ... | 1983 | 6401746 |
| the relationship of serum thyrotropin (tsh) to the thyroid hormones after oral tsh-releasing hormone in patients with preclinical hypothyroidism. | serum thyroid hormone and tsh concentrations were measured before and after oral trh (40 mg) administration in 46 women with preclinical hypothyroidism. preclinical hypothyroidism was defined as serum t4 in the normal range, a normal or elevated basal serum tsh, and an exaggerated serum tsh response to trh, in the absence of clinical manifestations of hypothyroidism. the results were compared to those in 22 normal women of the same age and body mass index. overall, the patients had significantly ... | 1983 | 6401757 |
| different prolactin, thyrotropin, and thyroxine responses after prolonged intermittent or continuous infusions of thyrotropin-releasing hormone in rhesus monkeys. | serum prl, tsh, and t4 secretion during prolonged continuous or intermittent iv infusions of trh were studied in 14 adult ovariectomized rhesus monkeys (macaca mulatta). for 9 days, trh was administered intermittently at 0.33 or 3.3 micrograms/min for 6 of every 60 min and continuously at 0.33 micrograms/min. with both modes, the prl levels and responsiveness to trh simulation peaked on day 1 and then fell to levels that were still higher than the preinfusion values; levels for the intermittentl ... | 1983 | 6401761 |
| thyrotropin secretion in patients with hyperparathyroidism or hypoparathyroidism: effect of serum calcium on thyrotropin release. | the influence of changes in the serum calcium concentration on tsh secretion was evaluated in patients with primary hyperparathyroidism and idiopathic hypoparathyroidism and in normal subjects. serum calcium concentrations were 12.7 +/- 0.8, 9.0 +/- 0.4, and 5.7 +/- 0.5 mg/100 ml in hyperparathyroid, normal, and hypoparathyroid subjects, respectively, and were significantly different from each other. serum t3 and t4 concentrations were comparable among the three groups. the basal serum tsh conce ... | 1983 | 6401763 |
| hypothalamic-pituitary function in patients with prolonged coma. | in eight patients (six males and two females) hospitalized for prolonged coma (164-1320 days; five patients were in traumatic coma, two after cardiac arrest during surgery, and one after a venomous scorpion sting), diurnal variation of cortisol secretion, human (l) gh, prl, tsh secretion as well as the release of the pituitary hormones after trh and l-dopa stimulation were assessed. serum t4 cortisol, hgh, hprl, and htsh levels were normal. the cortisol diurnal variation was preserved in six pat ... | 1983 | 6401764 |
| comparison of human thyroxine-binding globulin purification by affinity chromatography procedures. | three procedures for the isolation of thyroxine-binding globulin from human serum, using affinity chromatography on triiodothyronine (t3) linked to sepharose (a), thyroxine (t4) linked to sepharose (b) or t3 linked to epoxy-sepharose (c) as the first purification step, were compared. with the use of additional purification steps, the three procedures yielded pure thyroxine-binding globulin without desialylation. with procedure a, the initial binding of t4-binding globulin to t3-sepharose was ver ... | 1983 | 6402021 |
| comparison of plasma thyroxine levels following short exposure to cold and trh administration in intact and pituitary autografted quail (coturnix coturnix japonica). | the thyrotropic functional abilities of ectopically transplanted anterior pituitaries were tested by subjecting quail bearing their adenohypophysis in juxtarenal position either to a short cold exposure or to an intravenous injection of trh. thyroxine was determined in plasma samples collected from 20 to 120 min after treatment. intact birds exhibited increasing t4 levels up to a peak at 40 min, then decreasing slowly within 2 hr after either cold or trh stimulation. autografted birds exhibited ... | 1983 | 6402416 |
| thyroid hormones inhibit growth hormone secretion in domestic fowl (gallus domesticus). | the influence of thyroxine (t4) and tri-iodothyronine (t3) on the secretion of gh in immature fowl was investigated. in birds pretreated with i.m. injections of t4 (100 micrograms/day for 10 days or 250 micrograms/kg for 7 days) or t3 (250 micrograms/kg for 7 days) the basal plasma gh level was markedly reduced. a similar reduction in the basal plasma gh level was also observed 60 min after a single injection or t3 (25 and 250 micrograms/kg) or t4 (250 micrograms/kg). in control birds the concen ... | 1983 | 6402558 |
| variation in the release of thyroxine, triiodothyronine and growth hormone in response to thyrotrophin releasing hormone during development of the domestic fowl. | in newly hatched chicks, trh administration was followed by increased circulating concentrations of growth hormone (gh), thyroxine (t4) and 3,3',5-triiodothyronine (t3). little change in the circulating concentration of 3,3',5'-triiodothyronine (rt3) was however observed. the effect of trh on the circulating concentration of gh was not found in chick embryos at 17 or 19 days of incubation but was observed during pipping. the t4 response was maximal in newly hatched chicks and present in 17 and 1 ... | 1983 | 6402866 |
| increased serum reverse triiodothyronine in patients with hyperemesis gravidarum. | thyroid function and pituitary responsiveness to trh were studied in patients with hyperemesis gravidarum. serum t3 and t4 concentrations were normal. serum tbg levels in hyperemesis were normal for gestation, and the t4:tbg ratio was in the euthyroid range. in all patients a normal tsh response to trh was found. mean serum rt3 concentration was increased by 31% as compared to a control group of normal pregnant women (p less than 0.001). the data suggest that in patients with hyperemesis gravida ... | 1983 | 6402869 |
| thyroid function in patients with proteinuria and normal or increased serum creatinine concentration. | the thyroid function of 13 patients with proteinuria and normal serum creatinine level (group 1) and 15 patients with proteinuria and increased creatinine level (group 2) was investigated. the daily urinary t41- and t3 excretion was much higher in group 1 patients than in group 2 patients (37.1 +/- 25.9 nmol t4 vs 17.5 +/- 8.7 nmol t4, 3.3 +/- 1.6 nmol t3 vs 1.1 +/- 0.8 nmol t3, respectively) and correlated in both groups with the protein loss. none of the patients suffered from hypothyroidism a ... | 1983 | 6402873 |
| thyroxine and triiodothyronine levels in snell mice. | since no data are available concerning thyroid hormone levels in snell dwarf mice from birth on, a cross-sectional study was performed of l-thyroxine (t4) and l-triiodothyronine (t3) levels in blood or serum as a function of age of several litters, starting at birth. in normal snell mice t4 levels in blood and serum are changing with age. t4 increases during the first 2 weeks of age and declines thereafter, until adult levels of about 50 nmol/l are reached at 21 days of age. serum t3 values are ... | 1983 | 6402874 |
| structure of repaired sites in human dna synthesized in the presence of inhibitors of dna polymerases alpha and beta in human fibroblasts. | excision repair of ultraviolet damage in human fibroblasts was partially inhibited by drugs that block dna polymerases alpha or beta (cytosine arabinoside, aphidicolin and dideoxythymidine) causing a reduction in unscheduled synthesis and an accumulation of single-strand breaks. the strand breaks accumulated in the presence of aphidicolin could be resealed within 30 min after removal of the drug, but those accumulated by cytosine arabinoside took many hours. digestion of repaired dna with exonuc ... | 1983 | 6403037 |
| clinical evaluation of free thyroxine calculation from thyroxine and thyroxine binding globulin radioimmunoassays. | free t4 calculation was performed based on the equation of the law of mass action between t4 and tbg assessed by routine radioimmunoassay. to examine the validity of this calculation, sera from normal subjects, from hypo- and hyperthyroid patients, from subjects with hereditary deficiency or increase in tbg, and those from uncomplicated pregnancy were included in the assay and the results were compared with those directly measured by radioimmunoassay with encapsulated antibody. free t4 calculati ... | 1983 | 6403352 |
| dynamics of serum thyrotropin and thyroid hormone changes in fasting. | this study was designed to address the question of whether decreased hypothalamic trh secretion was responsible for the transient decline in serum tsh levels characteristic of the early phase of fasting in man. changes in serum tsh, total t4 (tt4), free t4 (ft4), and total t3 (tt3)/tt4 and total rt3(trt3)/tt4 ratio values together with plasma trh levels were evaluated before, during, and after a constant 48-h infusion of either trh (75 ng/min), or saline, initiated at 10 h into a 6-day fast, in ... | 1983 | 6403568 |
| interleukin 2-mediated immune interferon (ifn-gamma) production by human t cells and t cell subsets. | human interleukin 2 (il 2, or t cell growth factor), which was free of lectin and interferon activity (ifn), induced human peripheral t lymphocytes to produce immune ifn (ifn-gamma). in contrast, non-t cells and macrophages did not produce ifn-gamma in response to il 2. il 2 acted directly on unstimulated t cells to induce ifn-gamma production, and also acted in synergy with a suboptimal dose (2 micrograms/ml) of concanavalin a (con a) to enhance ifn-gamma production. the ifn-gamma-inducing acti ... | 1983 | 6403613 |
| thyroid state and mitochondrial population during cold exposure. | young rats exposed to the cold (4 degrees c) for 15-25 days exhibit remarkable modifications in their thyroid state and in the mitochondrial population of target organs such as liver. the serum total and free t3 levels more or less doubled (from 77 +/- 7 to 130 +/- 7 ng/100 ml and from 350 +/- 25 to 530 +/- 25 pg/100 ml, respectively) after 2 h of exposure while the serum total t4 levels underwent a limited and transitory increase; mitochondrial alpha-glycerophosphate dehydrogenase activity incr ... | 1983 | 6403920 |
| weaning in the rat: a study of hormonal influences. | the control of weaning was studied in rat pups aged 17-24 days. the influence of two hormones, thyroxine (t4) and corticosterone, and the effect of declining intestinal lactase activity were evaluated. hypothyroidism was induced by administration of n-propylthiouracil and hyperthyroidism was induced by injection of t4. hypothyroid pups failed to begin nibbling chow while littermates injected with t4 weaned normally. two abnormalities resulting from hypothyroidism, hypothermia and stunted incisor ... | 1983 | 6404184 |
| metabolic and endocrine investigations in women of normal weight with the bulimia syndrome. | bulimia is a disorder characterized by episodes of binge-eating. patients with this problem consume large amounts of food when binge-eating and, subsequently, to avoid weight gain, usually self-induce vomiting or induce diarrhea with laxatives. metabolic and endocrine investigations in six bulimic subjects of normal weight are reported. normal fasting plasma glucose concentrations and glucose tolerance were present in all. five subjects had normal serum t4 and t3 concentrations. only one subject ... | 1983 | 6404313 |
| influence of season on sexual development in heifers: age at puberty as related to growth and serum concentrations of gonadotropins, prolactin, thyroxine and progesterone. | an experiment was done to test the hypothesis that seasonal changes in environment during the first and second 6 months of life influence age at puberty in heifers. twenty-eight angus x holstein heifers, born in march (m) or september (s), were reared under natural conditions until 6 months of age. from 6 to 12 months of age, heifers were reared in environmental chambers programmed to simulate seasonal changes in temperature and photoperiod characteristic of spring, summer and early autumn (sp-f ... | 1983 | 6404318 |
| improved dialysis method for free thyroxin in serum compared with five commercial radioimmunoassays in nonthyroidal illness and subjects with abnormal concentrations of thyroxin-binding globulin. | we describe a method for free thyroxin (ft4) in serum, based on radioimmunoassay of t4 in serum dialysate, ft4(d). the method is analytically accurate, sensitive, reproducible, and suitable for routine use in the clinical laboratory. we compared results by this method with those obtained with five commercial ft4 assays (amerlex, gammacoat, immophase, liquisol, spiria) and the free t4 index (ft4i). in several of the patients with nonthyroidal illness ft4(d) was above normal and ft4 as measured wi ... | 1983 | 6404567 |
| response of thyroid hormones in peripheral and thyroid venous blood to trh administration in man. | thyroid vein and cubital vein samples were collected simultaneously in 6 moderately hypercalcemic patients and 1 eucalcemic hypothyroid patient, and thyroid hormones were measured in the serum in the basal state, as well as 30 and 60 min after intravenous administration of trh. no gradient was detectable between peripheral and thyroid blood in the case of t4, and no significant changes were observed following trh. the levels of t3 were higher in the thyroid venous effluent than in the periphery ... | 1983 | 6404747 |
| do prostatic biopsies 12 months or more after external irradiation for adenocarcinoma, stage iii, predict long-term survival? | serial biopsies of the prostate after high dose external irradiation for adenocarcinoma show a gradual disappearance of the neoplastic cells. with such treatment, results of the biopsies do not have any short term prognostic significance. however, positive biopsies 12 months or more after treatment are reputed to be an unfavorable sign for long-term survival. from august, 1970 through february, 1974, 46 consecutive patients with locally advanced (stage iii, c, or t3 and t4) adenocarcinoma of the ... | 1983 | 6404866 |
| modulation of t lymphocyte differentiation antigens: influence of aging. | in vitro modulation of human t lymphocyte surface differentiation antigens t3, t8, and t4, by their respective monoclonal antibodies, was studied as a function of donor age. kinetic studies performed on lymphocytes from young adults indicated that modulation is dependent on concentration of antibody used and duration of culture. okt3 modulates t3 rapidly (maximum at less than 24 hr) and relatively completely (79% at the highest concentration of antibody used). by 48 hr, regeneration of the t3 an ... | 1983 | 6406073 |
| thyroid hormone secretion rates: response to endogenous and exogenous tsh in man during surgery. | the thyroid hormone secretory response to tsh was studied in twenty-eight patients undergoing thyroid and parathyroid surgery. eighteen patients received bovine or human exogenous tsh by injection into a thyroid artery, and 10 received trh to stimulate endogenous tsh secretion. thyroid secretion rates of t4, t3, and rt3 were determined directly from measurement of blood flow and the hormone gradient across the gland. a significant secretory response was seen for all three hormones following tsh ... | 1983 | 6406108 |
| hyperthyroxinaemia: abnormal binding of t4 by an inherited albumin variant. | two euthyroid subjects with high total concentrations of t4 in their sera have been studied (j.d.: t4, 170; t3, 1.90; rt3, 0.54 nmol/l. e.t.: t4, 185; t3, 1.63; rt3, 0.37 nmol/l). concentrations of all three t4-binding proteins were within normal limits in both cases. however, on reverse-flow electrophoresis an abnormally large amount of thyroxine was found to travel with albumin. the three t4-binding proteins in the sera of both patients were separated from each other by a novel affinity chroma ... | 1983 | 6406109 |
| thyroid status in various degrees of protein-calorie malnutrition in children. | the thyroid functional parameters of 102 children with protein-calorie malnutrition (pcm) classified as undernourished, marasmic, kwashiorkor and marasmic-kwashiorkor were studied by measuring the serum t4, t3, t3 percentage uptake (t3%ut), free thyroxine index (fti), and (in a few subjects) tsh. total plasma proteins, albumin and globulin were also estimated. t4 was increased markedly in the undernourished children and significantly decreased in kwashiorkor and marasmic-kwashiorkor groups. ther ... | 1983 | 6406110 |
| increased serum concentration of t4-binding globulin in patients with hypogammaglobulinaemia. | patients with hypogammaglobulinaemia have been regularly found to have abnormal conventional thyroid function test results. the abnormality is due to an increased plasma concentration of t4-binding globulin (tbg). as the prevalence of autoimmune thyroid disease is probably increased in hypogammaglobulinaemia this further abnormality in the plasma proteins may lead to diagnostic confusion. administration of gammaglobulin by infusion causes a rapid but transient fall in plasma concentrations of tb ... | 1983 | 6406111 |
| external pituitary irradiation as a cause of trh deficiency in patients with pituitary adenomas. | the influence of external pituitary irradiation (xrt) on thyrotroph function and prl secretion was studied in twenty-five patients with pituitary adenomas, of whom eight had acromegaly. twenty-one patients had undergone subtotal operative removal of their adenomas 8-190 weeks (median 12 weeks) before xrt. following irradiation there was a significant reduction in peak serum tsh levels in response to i.v. trh (p less than 0.05, compared with before xrt). peak tsh levels returned to normal at 3 mo ... | 1983 | 6406112 |
| the effect of thyroid hormones in vitro and in vivo on hypothalamic neurotensin release and content. | neurotensin (nt) is a hypothalamic peptide which inhibits tsh secretion when administered intraventricularly to the rat. we have studied the effects of trh, tsh, t3, and rt3 on the release of immunoreactive nt (int) from incubations of freshly dissected sections of whole hypothalamic tissue removed from male rats. the effects of t4 or propylthiouracil administration in vivo on hypothalamic int content and release was examined as well. t3 (10(-7) m) stimulated int release in vitro [45.3 +/- (se) ... | 1983 | 6406207 |