Publications

increased risk of primary hypothyroidism in preterm infants.	serum levels of thyroid stimulating hormone, thyroxine, triiodothyronine, free t4, thyroxine-binding globulin, reverse t3, and the tsh secretory areas and peak t3 after intravenous injection of 40 micrograms thyrotropin-releasing hormone were determined weekly from day 5 to 6 to 11 weeks of age in 42 unselected full-term and 61 preterm belgian infants. the results on day 5 indicated a progressive deficit of thyroid function related to the degree of prematurity. in 92 infants this deficit progres ...	1984	6432991
decreased free fraction of serum thyroid hormones during carbohydrate overfeeding.	the impact of the increased t3 production induced by overfeeding is likely to be lessened if overfeeding also decreases the free fraction of thyroid hormones. therefore, we examined the effect of 17 to 20 days of carbohydrate overfeeding of five men on total serum t4 and t3 concentrations, the free fraction of these hormones, and serum concentrations of thyroid-hormone binding proteins, tbg, tbpa, and albumin. total serum t4 concentrations were unchanged by overfeeding and total serum t3 concent ...	1984	6433150
probing the infra-structure of thymidylate synthase and deoxycytidylate deaminase.	methods are described for preparing and structurally analyzing two enzymes involved in the formation of dtmp, deoxycytidylate deaminase and thymidylate synthase. in the latter case, it has been possible through the use of recombinant dna techniques with an amplification plasmid to obtain sufficient amounts of the e. coli and t4-phage synthases to complete the entire sequence of both enzymes by employing a combination of protein and dna sequencing methods. a comparative analysis of the l. casei a ...	1984	6433661
changes in circulating iodothyronines in diabetics with various degrees of metabolic control.	plasma tsh, total and free t3 and t4, reverse t3, blood ph, hbalc, ketonuria and glycosuria were evaluated in 8 subjects with diabetic ketoacidosis, in 54 diabetics of group 1 and group 2 without severe metabolic derangement and in 10 control women. the diabetics with ketoacidosis showed before intensive therapy low t3, total and free, and high reverse t3 concentrations as compared to controls (unpaired t-test, p less than 0.001). after one day of intensive therapy the decrease of hyperglycemia ...	1984	6433942
plasma concentrations of luteinising hormone, follicle stimulating hormone, androgen, growth hormone, prolactin, thyroxine and triiodothyronine during growth and sexual development in the cockerel.	changes in concentrations of plasma luteinising hormone (lh), follicle stimulating hormone (fsh), androgen, growth hormone (gh), prolactin (prl), thyroxine (t4) and triiodothyronine (t3) were measured during growth and sexual maturation in broiler cockerels reared in continuous light to 7 weeks and 14 h light/d thereafter. concentrations of lh and fsh began to increase between 13 and 15 weeks, while those of androgens increased between 16 and 17 weeks. fsh concentration increased faster than tha ...	1984	6434159
hypothalamo-adenohypophyseal-thyroid interrelationships in the chick embryo. vi. midgestational adenohypophyseal sensitivity to thyrotrophin-releasing hormone.	the functional abilities of 9.5-, 10.5-, 11.5-, and 12.5-day-old chick embryos to respond to exogenous thyrotrophin-releasing hormone (trh) were evaluated by means of changes in plasma total thyroxine (t4). t4 concentrations were determined 3.0, 6.0, 12.0, and 24.0 hr after trh treatment. the data of the present investigation show that chick embryo adenohypophyseal sensitivity to exogenous trh, as evidenced by changes in plasma t4 levels, increase during the 10.5- to 12.5-day incubation interval ...	1984	6434370
low thyroxine levels in some hyperprolactinemic patients due to dopaminergic suppression of thyrotropin.	the serum free t4 index (ft4i) was at or below the lower limit of normal in 8 of 55 unselected patients with hyperprolactinemia. serum levels of t3 were normal and none of the patients had clinical evidence of hypothyroidism. in patients with low ft4i the serum tsh was within the normal range and tsh was released normally after administration of trh, indicating normal pituitary tsh reserve. serum tsh also increased after administration of the dopamine antagonist domperidone. the tsh response to ...	1984	6434574
thyroglobulin release after graded endogenous thyrotropin stimulation in man: lack of correlation with thyroid hormone response.	the serum thyroglobulin (tg), t3, and t4 responses to graded endogenous tsh stimulation were examined in 30 normal subjects for up to 96 h after trh administration. increasing tsh rises were elicited by trh administration as follows: 1) 500 micrograms iv as a single bolus in 10 subjects [mean peak serum tsh, 14.3 +/- 1.8 (se) microu/ml]; 2) 1000 micrograms infused iv in 2 h in 10 subjects (mean peak tsh, 25.5 +/- 2.6 microu/ml); 3) 40 mg orally in 10 subjects (mean peak tsh, 27.5 +/- 3.0 microu/ ...	1984	6434589
[hypotheses on the validity of the radioimmunologic measurement of ft4].	in patients undergoing long-term thyroid hormone therapy with constant doses the results of ft4 concentrations measured by radioimmunoassay (ft4-amerlex) were compared with calculated ft4 values and related to total thyroxine, serum tbg levels, respectively t4/tbg, to control the validity of radioimmunologic ft4 measurements for clinical routine diagnostic purposes. based on mathematical analyses on the interdependence of these values the following principles were confirmed: free thyroxine measu ...	1984	6434795
the distribution of thyrotropin-releasing hormone (trh) in the rhesus monkey spinal cord.	the distribution of thyrotropin-releasing hormone (trh) in the rhesus monkey spinal cord was studied using a highly specific antibody to trh and the indirect peroxidase-antiperoxidase technique. trh-positive fibers were found at all levels of the spinal cord and were in greatest concentration in the ventral gray, intermediolateral column and central gray. all motor nuclear groups in lamina ix of the ventral gray were innervated by trh, frequently in close association with perikarya of alpha-moto ...	1984	6435101
seasonal variations of total and free thyroid hormones in healthy men: a chronobiological study.	the seasonal variations of iodothyronines and tsh serum concentrations were evaluated in 24 healthy subjects of both sexes. using a 12 month cosine function, a significant circannual rhythm was found in t3, t4 and free t4 whose maximal values were found in september for t3, in august for t4 and in october for free t4. no significant seasonal variations in free t3 or tsh were found. some circannual but not sinusoidal changes were found for reverse t3 and tbg. a positive linear correlation between ...	1984	6435369
endocrine involvement in children with beta-thalassaemia major. transverse and longitudinal studies. i. pituitary-thyroidal axis function and its correlation with serum ferritin levels.	thyroid function was investigated by a trh test in 24 clinically prepubertal children, 3-15 years old with beta-thalassaemia major; in 7 of them the test was repeated once and in 2 twice at intervals of at least 12 months. basal t4, t3, tbg and tsh levels and the tsh levels during a trh test were determined and correlated with age and serum ferritin levels. basal serum t4, t3 and tbg levels were lower and serum tsh levels were higher during the test and in the basal state in thalassaemia major c ...	1984	6435370
thyroid hormone concentrations and free thyroxine status in neonatal venous and capillary serum pairs.	the levels of thyroid hormones in paired venous and capillary serum samples taken from 68 healthy full-term neonates were determined by radioimmunoassay. compared with capillary values, total thyroxine (t4), thyrotropin (tsh) and thyroxine-binding globulin (tbg) each showed a significant decrease in venous serum. the mean venous and capillary concentrations of tri-iodothyronine (t3), reverse tri-iodothyronine (rt3) and free thyroxine (ft4) were not significantly different; however, in each case ...	1984	6435500
thyroid status in patients after acute myocardial infarction.	subjects followed serially after acute myocardial infarction demonstrated a rapid and sustained fall in serum total tri-iodothyronine (t3) concentration and a rise in reverse tri-iodothyronine (rt3) concentration. there was a transient fall in total thyroxine (t4) concentration. thyroxine binding globulin (tbg) levels were unchanged after acute myocardial infarction but prolonged falls were observed in thyroxine binding prealbumin (tbpa) and albumin concentrations. in contrast to the fall in tot ...	1984	6435938
influence of chronic thyroxine treatment on plasma hormone and metabolite concentrations and on responses to insulin, glucagon and thyrotrophin releasing hormone in adult sheep.	four adult sheep fed twice daily were given daily subcutaneous injections of saline for four weeks, followed by a similar period of daily l-thyroxine (t4) injection (1 mg/day). t4 treatment increased basal plasma concentrations of t4, triiodothyronine (t3), insulin and glucose, together with t3-uptake and the free thyroxine index, while cholesterol and urea concentrations decreased. t4 treatment reduced the rise in prolactin levels after the morning meal. thyrotrophin releasing hormone (trh) inj ...	1984	6436158
cisplatin and full dose irradiation for patients with invasive bladder carcinoma: a preliminary report of tolerance and local response.	twenty-seven patients with invasive bladder carcinoma (clinical stages t2 to t4) who were not candidates for cystectomy were treated by transurethral resection, cis-diamminedichloroplatinum (cisplatin) and full dose radiotherapy according to protocol 8 of the national bladder cancer collaborative group a. nausea and vomiting occurred in 74 per cent of the patients but were mild in 41 per cent. maximum followup was 27 months and during that time 3 significant toxic reactions occurred: renal failu ...	1984	6436510
influence of clofibrate on thyroid hormone and muscle protein turnover.	clofibrate, a hypolipidemic agent, has been shown to increase muscle protein degradation. the possible role of thyroid hormones in this phenomena was examined. clofibrate treatment of rats for 2 weeks resulted in a significant decrease in total thyroxine and triiodothyronine levels in serum. reverse t3 and resin uptake values remained unchanged. when exogenous thyroxine was co-administered with clofibrate, serum tsh levels were suppressed, but the increased muscle protein degradation was not rev ...	1984	6436638
thyroid hormone levels in human breast cyst fluid.	radioimmunoassayable levels of total and free 3,5,3'-triodothyronine (t3) and thyroxine (t4), thyroid stimulating hormone (tsh), thyroxine binding globulin (tbg) and prolactin (prl) were measured in a series of samples of breast cyst fluid (bcf) aspirated from 73 pre-menopausal women with gross cystic disease of the breast and in coincidental blood samples. in bcf free t3 and free t4 were consistently higher than in plasma (p less than 0.001) as was also total t3 in the majority of cases (p less ...	1984	6437106
effect of danazol on thyroid function in postmenopausal women.	during treatment with danazol the serum concentration of thyroxin-binding globulin (tbg) decreases. this effect is probably a direct effect on tbg production at the cellular level. in order to exclude an indirect effect on tbg production via the well known suppressing effect of danazol on serum estrogen concentrations, the following study was performed. twelve healthy female volunteers, who were at least 3 years past the menopause and with serum-estradiol levels below 100 pmol/l, were treated wi ...	1984	6437126
altered responses of prolactin, luteinizing hormone and follicle stimulating hormone secretion to thyrotrophin releasing hormone/gonadotrophin releasing hormone stimulation in cyclical mastalgia.	a generalized abnormality of hypothalamopituitary function was found in 17 patients with cyclical pronounced mastalgia compared with 11 controls by using a combined thyrotrophin releasing hormone and gonadotrophin releasing hormone test. the release of prolactin, luteinizing hormone and follicle stimulating hormone was significantly greater in cyclical mastalgia patients than in controls. basal thyrotrophin, t3 and t4 levels were within the normal range in both groups indicating normal thyroid s ...	1984	6437468
familial growth retardation with isolated thyroid-stimulating hormone deficiency.	three brothers with isolated thyroid-stimulating hormone (tsh) deficiency were observed at ages 17, 15, and 10 years. they suffered from severely retarded growth, with a marked retardation in bone maturation. their serum t4, t3, and tsh levels were low. serum thyrotropin-releasing hormone (trh) concentration was normal. no increases in tsh levels were elicited during the trh test. the other pituitary hormones, adrenocorticotropic hormone, growth hormone, follicle-stimulating hormone, luteinizing ...	1984	6437722
ethanol inhibition of pituitary-thyroid axis: an effect secondary to nutritional deficiency.	ethanol as either 20% or 36% of total calories in a lieber diet was administered to male rats. at these concentrations, ethanol consumption relative to body weight did not differ. pair-fed controls were restricted to the amount of calories consumed by rats given ethanol. under these conditions, a direct effect of ethanol on the hypothalamic-hypophyseal-thyroid axis could not be demonstrated. there were no differences between pair-fed control and ethanol treated rats in serum or pituitary tsh, ts ...	1984	6437803
[local mitomycin-c therapy of infiltrating bladder cancer].	adjuvant local chemotherapy for superficial cancer of the urinary bladder (ta-tis) is meanwhile performed on a nearly standardized level. the indication for infiltrating tumours (t1-t4) however is controversial. the prevention of tumour cell implantation which is promoted by transurethral resections is advantageous. on the other hand a curative effect cannot be expected from local chemotherapy in infiltrating tumours. the long-term results of adjuvant local chemotherapy in 86 patients with infil ...	1984	6437950
effect of metergoline on prolactin, follicle stimulating hormone, luteinizing hormone and thyroid stimulating hormone response to trh and lhrh in normal men and women.	metergoline, a prolactin (prl)-lowering drug with an antiserotoninergic activity, is known to restore menstruations and fertility in hyper-prl patients even when prl levels are not normalized. this suggests that metergoline might also affect gonadotropins release. in a double-blind cross-over study in 8 normal males, repeated administration of metergoline enhanced the lh response to lhrh and reduced the prl response to trh; for females, three different tests were performed on days 5, 8 and 21 of ...	1984	6437954
effect of non aromatizable androgens on lhrh and trh responses in primary testicular failure.	we have assessed the gonadotropin, tsh and prl responses to the non aromatizable androgens, mesterolone and fluoxymestrone, in 27 patients with primary testicular failure. all patients were given a bolus of lhrh (100 micrograms) and trh (200 micrograms) at zero time. nine subjects received a further bolus of trh at 30 mins. the latter were then given mesterolone 150 mg daily for 6 weeks. the remaining subjects received fluoxymesterone 5 mg daily for 4 weeks and 10 mg daily for 2 weeks. on the la ...	1984	6437958
circulating thyroid hormones in progressive renal failure in the baboon (papio ursinus).	in order to examine the effects of developing renal failure on circulating thyroid hormones, serum concentrations of thyroxine (t4), free t4 (ft4), triiodothyronine (t3) and reverse t3 (rt3) and tbg capacity were measured in 9 baboons before and during the progress of acute (mean survival 12 days), subacute (32 days) and chronic (120 days) renal failure following allogeneic renal transplantation. irrespective of the rate of development of renal failure, there were significant, non linear (power ...	1984	6438218
congenital goitrous hypothyroidism: discordant systolic time intervals, pituitary and peripheral responses to high daily doses of t4 or t3 therapy.	left ventricular performance was studied by a noninvasive technique through the measurement of the systolic time intervals (total eletromechanical systole, left ventricular ejection (lvet) time, preejection period (pep) and pep/lvet ratio (systolic quotient) in 8 young adults with congenital goitrous hypothyroidism. all subjects showed lengthening of pep, shortening of lvet and an increased pep/lvet ratio associated with low serum t3 and t4, an exaggerated tsh response to trh, high levels of ser ...	1984	6438221
[thyroid diagnosis today].	for functional diagnostics the ft4 index is calculated from the t4 and t3u values. hyperthyroidism is suggested or borderline values are found; the t3 test is carried out. an index of free iodine hormones (ifih) can be calculated. (formula; see text) hypothyroidism and borderline cases require tsh evaluation or even a trh test. t4 and t3 autoantibodies can cause high or low values in spite of euthyroidism or hypothyroidism. differences in ft4 values are found if the kits used were not made by th ...	1984	6438696
[blood t lymphocyte populations in the hemophiliac].	we have studied a group of 31 hemophiliac patients (hemophilia a: 26 patients, hemophilia b: 5 patients); 29 healthy men were used as controls. hemophiliac patients had increased percentages of suppressor t-lymphocytes and depressed t4/t8 ratios. these abnormalities were found to be significantly correlated with the amount of f viii used per year.	1984	6438768
[immunological study of a hemophiliac treated according to the bonn protocol for 2 1/2 years].	a major haemophiliac a, 27 years old, has been treated during 30 months, with high dosage of imported factor viii, in order to reduce the titer of a f viii antibody. a good clinical result has been obtained. no sign of immunodeficiency has been observed. normal values were obtained for t4/t8, ratio b2 microglobulin and no antibody was detected against the lav virus isolated from cases of aids.	1984	6438769
[serum thyroxine (t4) levels and thyroxine-binding capacity of patients with corticosteroid-dependent and atopic bronchial asthma].	the patients with bronchial asthma, treated a long time with corticosteroid s (the so called cortico-dependent bronchial asthma) are an adequate model for the study on the dependence between the function of the thyroid gland and the effect of glucocorticosteroids. the study was carried out on 12 patients with atopic, 14--with cortico-dependent bronchial asthma and ii--healthy subjects. the function of the thyroid gland was assessed by the serum level od thyroxine and thyroxine-binding capacity, ...	1984	6438915
age-related alterations of pituitary-thyroid function in normal female subjects and in female patients with simple goitre.	age-related alterations in pituitary-thyroid function were studied in 173 female patients with simple goitre and in 70 normal female subjects. they were divided into 4 groups according to age: a group, less than 19 years; b group, 20 to 29 years; c group, 30 to 39 years; d group, 40 to 59 years. serum triiodothyronine (t3) concentrations decreased progressively but insignificantly with age in female patients with simple goitre and in normal female subjects, whereas serum thyroxine (t4) concentra ...	1984	6438974
carbamazepine and thyroid function in affectively ill patients. clinical and theoretical implications.	thyroid function was examined in 50 affectively ill patients before and four weeks after carbamazepine treatment. carbamazepine significantly and substantially decreased peripheral thyroid hormone levels while increases in thyrotropin levels, although significant, were of much smaller magnitude. furthermore, the decreases in levels of thyroxine (t4) and free t4 were significantly greater in carbamazepine responders than in nonresponders. these findings are discussed in light of current theories ...	1984	6439170
trh response pattern in adolescent schizophrenic males.	a marked elevation in human growth hormone (gh) following intravenous infusion of thyrotropin releasing hormone (trh) was seen in three of seven adolescent male schizophrenic patients receiving neuroleptic drugs, and in one of five controls matched for age, sex, and developmental stage, receiving the same drugs. a positive family history for schizophrenia was noted in all three schizophrenic 'responders' but in only one of the remaining patients. the response patterns of thyroid stimulating horm ...	1984	6439274
a prealbumin variant with an increased affinity for t4 and reverse-t3.	a euthyroid adult female (lc) was found to have persistently raised concentrations of total t4 (159 nmol/l) and rt3 (500 pmol/l) in her serum in association with a normal t3 (2.1 nmol/l). serum concentrations of all three t4-binding proteins were within normal limits. a variant prealbumin with an increased affinity for t4 was found to be responsible for the raised serum level of t4. unlike normal prealbumin, the variant also bound appreciable amounts of rt3. the affinity constant for t4 binding ...	1984	6439433
thyroregulatory changes associated with smoking in 70-year-old men.	in a previous study we have analysed serum free t4 concentrations in a representative population of 70-year-old men. in the present study the effect of previous or present tobacco smoking on free t4, t4, t3, rt3, tsh and thyroid hormone binding proteins was analysed in 181 of the 460 men, excluding those with past or present goitre, those who were obviously ill or had died between 70 and 75 years of age and those who had any disease or medication influencing free t4 concentrations. smokers had h ...	1984	6439438
transient thyrotoxicosis in endemic goitre patients following exposure to a normal iodine intake.	twenty-three endemic goitrous subjects (goitre grade: iii and iv) that were living in a chronic iodine-deficient area (iodine intake: less than 40 micrograms i/d) were submitted to clinical and laboratory evaluation within 3-8 weeks of arrival at the metropolitan area of são paulo, where daily iodine intake is estimated to be 150-200 micrograms i/d. eight patients developed a mild thyrotoxic state (t4 = 14.7 +/- 2.3 micrograms/dl, t3 = 279 +/- 55 ng/dl, no tsh response to trh). five additional s ...	1984	6439440
inhibition of tsh-stimulated thyroid hormone release and potentiation of trh-stimulated tsh release by indomethacin in perifusion systems of rat thyroids and pituitaries.	using indomethacin (ind), a prostaglandin synthesis inhibitor, in vivo experiments in rats and in vitro experiments with perifusion systems of rat thyroids and pituitaries were conducted. after 35 days of intragastric infusion of ind, serum tsh levels were markedly increased, the thyroid was swollen and, as a consequence, t3 and t4 levels were normal. the t3 release from perifused rat thyroids under continuous stimulation with 10 mu/ml tsh was inhibited significantly (p less than 0.01) by 1.0 x ...	1984	6439574
serum tsh, t4, t3, ft4, ft3, rt3, and tbg in youngsters with non-ketotic insulin-dependent diabetes mellitus.	several parameters of thyroid function were studied in 112 non-ketoacidotic youngsters with insulin-dependent diabetes mellitus (iddm). levels of thyroxine (t4), reverse triiodothyronine (rt3), thyroxine-binding globulin (tbg) and t3 were lower than in controls, whereas ft4, and ft3 were normal. t4 levels in iddm patients were positively related to t3, rt3 and tbg, and inversely related to haemoglobin a1 (hba1). however, only 4 patients showed biochemical hypothyroidism (t4 less than 5 microgram ...	1984	6439616
a study of pituitary-thyroid function during exercise in man.	exercise induced modulations in circulatory t4, t3 and tsh were monitored in 14 healthy euthyroid male volunteers undergoing exercise on a bicycle ergometer at 750 kpm for 20 minutes. tsh response to 100 micrograms trh was also studied in 4 exercising and 4 resting subjects. serial blood samples were obtained before, during and after the exercise. serum t4 exhibited a significant decrease (p less than 0.05) from 9.6 +/- 0.49 microgram/dl (mean +/- se) to 8.3 +/- 0.47 microgram/dl at 20 min after ...	1984	6439634
improved survival in carcinoma of the nasopharynx.	between 1970 and 1980, we treated 107 previously untreated patients with biopsy-proven carcinoma of the nasopharynx by megavoltage external radiation therapy to the primary site, base of the skull, and both sides of the neck. eighty-seven percent of the patients had stage iv disease (american joint committee 1980), 53% had t4 primaries, and 73% had palpable cervical metastases. the histology was anaplastic or poorly differentiated carcinoma in 81%. the observed 5-year survival rate was 35% for t ...	1984	6439690
mixed beam radiation therapy for unresectable squamous cell carcinomas of the head and neck: the results of a randomized rtog study.	three hundred and twenty-two patients with inoperable squamous cell carcinomas of the head and neck were entered on a randomized study comparing "mixed beam" radiation therapy with photon radiation therapy. patients with histologically proven tumors of t-stage t2, t3, or t4 and any n-stage originating in the oral cavity, oropharynx, supraglottic larynx, or hypopharynx were eligible. one hundred forty-five patients were randomized to photon treatment and 177 were randomized to mixed beam treatmen ...	1984	6439699
squamous cell carcinoma of the supraglottic larynx treated with radical irradiation: analysis of treatment parameters and results.	eighty-one patients were treated with radical radiation therapy, with or without immediate neck dissection(s), for squamous cell carcinoma of the supraglottic larynx from october 1964 through may 1981. there is a 2-year minimum follow-up on all patients; 75/81 (93%) have a minimum 3-year follow-up, and 58/81 (72%) have at least a 5-year follow-up. patients were staged according to the 1983 ajcc staging system. patients were excluded from the local control analysis if they died less than 2 years ...	1984	6439701
iodothyronine 5'-deiodinase in rat kidney microsomes. kinetic behavior at low substrate concentrations.	the thiol-activated enzymatic outer-ring monodeiodination of iodothyronines by rat kidney microsomes at low (nanomolar) substrate concentrations shows an apparently sequential reaction mechanism and is further characterized by insensitivity to inhibition by dicoumarol, a moderate sensitivity to inhibition by propylthiouracil (ki = 100 microm) and iopanoic acid (ki = 0.9 mm), responsiveness to 5 mm glutathione (gsh), and a thermal activation profile that is concave downward with a td of approxima ...	1984	6439742
tsh secretion in thalassemia.	thyroid function has been evaluated in 6 prepubertal male and 9 female thalassemic patients. four of the latter were sexually immature (group i), with very low estradiol levels and the remainder had more advanced sexual development (group ii). subjects were challenged with trh and the response compared to adult controls and a group of 15 males aged 13-18 years with constitutional delayed adolescence. all patient groups and controls had normal levels of t4, t3 and t3 resin uptake. when compared t ...	1984	6439771
recovery of serum tsh and thyroid hormones after 3'isopropyl-3,5-diiodo-l-thyronine (diip) treatment: absence of inhibiting effect of bromocriptine on tsh secretion and evidence for autoregulation of serum t3 levels.	bromocriptine, because of its dopaminergic activity, could possibly inhibit tsh secretion. this hypothesis was tested in 7 normal male volunteers. thyroid function was suppressed with the very potent thyromimetic analogue, 3'isopropyl-3,5-diiodo-l-thyronine (diip). we wanted to observe, after stopping this treatment, whether the return of serum t3, t4, rt3 and tsh values was influenced by concomitant bromocriptine treatment (5 mg/day). for comparison, the diip study was also performed without br ...	1984	6439772
interaction of a streptococcal cell wall tetraheteroglycan and salmonella telaviv lipopolysaccharide with polymeric mcpc 870 and mopc 384 mouse iga myeloma proteins.	interactions of polymeric mcpc 870 and mopc 384 mouse iga myeloma proteins with a streptococcal cell wall tetraheteroglycan (t4-antigen), salmonella tranoroa lipopolysaccharide (lps), s. telaviv lps and its lipid a free polysaccharide were examined by the quantitative precipitin method. hapten inhibition of myeloma protein precipitation by t4-antigen or s. telaviv lps indicates a complex anticarbohydrate specificity for 870 and 384 protein combining sites involving several sugars. while the comb ...	1984	6440009
possible altered dopaminergic modulation of pituitary function in normal-menstruating women with insulin dependent diabetes mellitus (iddm).	in order to assess whether a possible altered dopamine activity in normal-menstruating diabetic patients may influence the pituitary hormone secretion we have measured the basal serum concentrations of prl, lh and fsh in 28 patients with insulin dependent diabetes mellitus (iddm) and in 55 normal-menstruating women at day 3 to 6 of the menstrual cycle. in addition basal levels of oestradiol-17 beta, tsh, thyroxine (t4), triiodothyronine (t3) and resin-t3 uptake (rt3u) were determined in 17 patie ...	1984	6440390
resistance of peripheral tissues and pituitary to thyroid hormone.	we describe a 29-year-old male with thyroid hormone resistance. he was first seen because of a goiter, and was considered to have hyperthyroid graves' disease. despite subtotal thyroidectomy followed by radioiodine therapy, serum thyroxine levels were elevated with high serum tsh levels. baseline thyroid function showed serum thyroxine of 16.6 micrograms/dl, free thyroxine of 4.60 ng/dl, triiodothyronine of 197 ng/dl, and tsh of 34 microu/ml. triiodothyronine administration by gradually increase ...	1984	6440779
the thyroid reserve in children with chronic lymphocytic thyroiditis revealed by the thyrotropin-releasing hormone and thyroid-stimulating hormone tests.	serum thyroid hormone and tsh concentrations were measured before and after the administration of trh (10 micrograms/kg body weight) and bovine tsh (10 iu) in 14 children with chronic lymphocytic thyroiditis. the trh test showed that the responsiveness of tsh was positively correlated with the basal tsh (p less than 0.001) and inversely with the increase in serum thyroid hormones, for delta t3 (p less than 0.05) and for delta t4 (p less than 0.001). overall, the patients had significantly lower ...	1984	6440780
synthesis and expression of rnase t1 gene.	in order to obtain knowledges about structure-function relationship of ribonuclease t1, we synthesized a structural gene for rnase t1 and several its modified genes. using amino acid codons frequently used in escherichia coli we designed genes consist of 328 x 2 bases. synthesis of oligodeoxynucleotides with 9-20 base lengths was performed by 1% polystyrene supported triester approach and resulting 42 oligomers were joined together using t4 dna ligase. the product was analyzed and utilyzed to co ...	1984	6441155
in vitro inhibition of growth of neisseria gonorrhoeae by neisseria meningitidis isolated from the pharynx of homosexual men.	despite the high prevalence of pharyngeal gonorrhea and of meningococcal carriage among homosexual men, neisseria gonorrhoeae and neisseria meningitidis are rarely co-isolated from the throat. forty-seven meningococcal isolates from the pharynx of homosexual men were examined, by a lawn-spotting method, for their ability to inhibit n. gonorrhoeae in vitro. eight (17%) of the meningococcal isolates were inhibitory when tested against gonococci from the same patient, while 31 (66%) were inhibitory ...	1984	6441274
prognostic significance of clinical nodal involvement in patients treated by radical radiotherapy for a locally advanced breast cancer.	a group of 230 female patients, treated between 1960-1976 with radical megavoltage radiotherapy for locally advanced breast cancer (t3 greater than 7 cm-t4 stage), was analyzed retrospectively. those with inflammatory cancer or evidence of disseminated metastatic disease were excluded. clinical axillary nodal involvement appears to be a very important prognostic feature. actuarial disease-free survival at 5 years for the 109 patients with clinically negative nodes (n0n1a) is 52%; whereas it is 2 ...	1984	6442097
radiation treatment of lateral epilaryngeal cancer. prognostic factors and results.	treatment results of epilaryngeal cancer are rarely individualized in the world literature. for this purpose, we have reviewed the records of 167 patients with squamous cell carcinoma of the lateral epilarynx who received radical radiotherapy at the institut curie on a megavoltage unit, between 1959-1975. two-thirds of the lesions were located at the junction of the ary- and pharyngo-epiglottic folds and lateral border of the epiglottis. forty-four percent of patients had advanced primary lesion ...	1984	6442098
treatment of squamous carcinoma of the retromolar trigone.	since squamous carcinoma of the retromolar trigone is unusual, there is a paucity of information in the world's literature to use as a reference for selecting treatment and determining pertinent factors affecting prognosis. consequently, an analysis of the medical records of 110 patients with biopsy proven squamous carcinoma originating in the retromolar trigone, seen and treated entirely at the university of texas m.d. anderson hospital and tumor institute at houston from 1965-1977, with at lea ...	1984	6442099
[effect of calcitonin on the secretion of prl, tsh, gh, lh, fsh, cortisol, t3 and t4].		1984	6442231
t-subset abnormalities in thalassaemia intermedia: possible evidence for a thymus functional deficiency.	peripheral blood t-lymphocyte subsets, evaluated by means of a series of monoclonal antibodies, were assessed in 14 patients affected by thalassaemia intermedia, 7 of them previously splenectomized. a significant reduction of t+4 cells ('helper' t cells) was found in almost all patients, whereas t+8 cells ('suppressor/cytotoxic') showed a marked increase only in splenectomized subjects. together with these quantitative t-subset abnormalities, which seemed to be partly affected by either splenect ...	1984	6442519
altered distribution of lymphocyte subpopulations and augmentation of lymphocyte proliferation in chronic pcb poisoned patients.	to clarify the mechanism of immunotoxicity of polychlorinated biphenyls (pcb), delayed type hypersensitivity skin test, lymphoproliferative responses, and lymphocyte subpopulations defined by monoclonal antibodies were performed on 30 patients and 38 age/sex-matched healthy individuals. three years ago the patients had ingested rice bran oil accidentally contaminated by pcb. except for lymphocyte proliferation, the chronic effect of pcb and its derivatives upon cell-mediated immunity (cmi) in th ...	1984	6442659
normalization of thyroid stimulating hormone levels in acromegalic patients after selective adenomectomy.	changes in tsh secretion in six acromegalic patients were studied before and after transsphenoidal adenomectomy (hardy's method) and compared to normal subjects and six patients with prolactinoma. basal serum gh levels ranging from 5 to over 250 ng/ml before adenomectomy decreased to below 5 ng/ml after the operation, and the abnormal responses of gh to trh observed initially in three of the six patients almost disappeared in the post-adenomectomy period. the response of serum tsh to trh in acro ...	1984	6442697
plasma thyroid hormone concentrations in growing beef steers implanted with estrogenic anabolic growth promotants.	the effect of estrogenic anabolic compounds on plasma thyroid hormone concentrations was investigated in growing beef steers. sixteen hereford beef steers, weighing approximately 380 kg, were randomly placed into four groups and assigned to one of the following treatments: 36 mg implant of zeranol, 36 mg implant of diethylstilbestrol (des), one implant of synovex-s and an unimplanted control. total thyroxine (t4) and triiodothyronine (t3) concentrations were analyzed from plasma samples collecte ...	1984	6442705
altered hypothalamic-pituitary-testicular function in incomplete testicular feminization syndrome.	an 18-year-old 46 xy patient with the syndrome of incomplete testicular feminization was investigated. the clinical phenotypic features were distinctive and typical of the 4 46 xy cases previously reported. the findings of elevated plasma t4 with evidence of incomplete development of female secondary sex characteristics suggest partial end organ insensitivity to the androgen at the target tissues. this possibility is substantiated by the high plasma lh level, presumably the consequence of the re ...	1984	6442862
comparison of goose-type, chicken-type, and phage-type lysozymes illustrates the changes that occur in both amino acid sequence and three-dimensional structure during evolution.	the three-dimensional structure of goose-type lysozyme (gewl), determined by x-ray crystallography and refined at high resolution, has similarities to the structures of hen (chicken) egg-white lysozyme (hewl) and bacteriophage t4 lysozyme (t4l). the nature of the structural correspondence suggests that all three classes of lysozyme diverged from a common evolutionary precursor, even though their amino acid sequences appear to be unrelated (grütter et al. 1983). in this paper we make detailed com ...	1984	6442995
serum and urine thyroid hormone levels in healthy preterm and small for date infants on the first and fifth day of life.	serum levels of thyroxine (t4), triiodothyronine (t3), reverse triiodothyronine (rt3), thyroxine binding globulin (tbg) and thyrotropin (tsh) were determined on the first and the fifth day of life in three groups of healthy premature infants (group i: 26-32 weeks of gestation, group ii: 33-36 weeks, and group iii: full term but small for date). urine t4 and t3 were also determined. t4 and t3 serum concentrations increased from group i to group iii, but were similar on day 1 and 5 in each group. ...	1984	6443359
t lymphocyte culture established by repeated stimulation with the autologous lymphoblastoid line. mhc class ii restricted interactions with b blasts.	an okt3+t4+t8-dr+ lymphocyte line was developed from an epstein-barr virus (ebv) seropositive individual by repeated stimulation in vitro with autologous ebv-infected b cells. the t cell population designated e-44 was carried for eight months in the presence of interleukin-2 and was repeatedly tested for cytotoxicity, proliferation and lymphokine production in response to the autologous and a panel of allogenic b cells. the e-44 cells lysed the autologous lymphoblastoid cell lines (lcl) and allo ...	1984	6443579
acute effect of exogenous thyroxine dose on serum thyroxine and thyrotrophin levels in treated hypothyroid patients.	acute effects of exogenous thyroxine on the serum thyroxine (t4), free thyroxine (ft4) and thyrotrophin (tsh) levels were studied in 20 hypothyroid women during the long-term maintenance therapy. all patients were euthyroid by clinical and laboratory parameters (t4). in nine patients tsh secretion was totally suppressed (less than 1 mu/l) by the mean dose of 178 micrograms thyroxine. eleven patients had tsh values greater than 1 mu/l. their mean thyroxine dose (132 micrograms) was not significan ...	1984	6463564
[carcinoma of the nasopharynx. clinical signs and therapeutic problems].	most of the carcinoma of the nasopharynx diagnosed in our country, are loco-regionally advanced disease. thus 31/54 (57%) of our patients referred to the centre claudius regaud between 1970 and 1980 were t2 n3, t3 n3, t4 n0 or n1 n2 n3. in spite of this poor initial presentation external radiotherapy can achieve a quite good rate of tumoral control inside the treated volume. in our series there were 17/47 (36%) tumoral and/or nodal recurrences and 7/47 (15%) metastases without local or regional ...	1984	6465745
[the surface of epiphyses of the knee: index of the duration of neonatal hypothyroidism].	the surfaces of the epiphyses of the knees were calculated in 34 neonates with hypothyroidism detected with a systematic screening and in 32 normal neonates. in the group of neonates with hypothyroidism, the surface of the lower femoral point was 12.7 +/- 0.9 mm2 and that of the upper tibial point 1.8 +/- 0.9 mm2. there was a significant difference (p less than 0.01) for both epiphyses between children of the 2 groups. the use of mathematical formula excluding non specific factors showed signifi ...	1984	6466032
[therapy and treatment results of cervical cancer in the medical school of the friedrich schiller university of jena from 1965 to 1976 (report on 1453 cases)].	in this paper, therapeutic results of 1,453 cervical cancer patients stage t1-t4 who have been treated at the gynaecological hospital and the radiological hospital of jena university are reported. the overall five-year survival rate amounted to 68.4 per cent. surgical and radiological therapeutic measures are demonstrated with regard to their development and to side effects between 1965 and 1983. as a consequence of the results obtained the necessity for treating cervical cancer patients in a ca ...	1984	6466056
permanent peripheral hearing system alteration following transient neonatal hyperthyroidism in rats.	maturation of the peripheral auditory system was monitored with the brainstem response audiometry (bsra) technique in l-thyroxine (t4)-injected rats. neonatal hyperthyroidism (nh) was induced by daily injections of t4 from birth to 20 days. following an initial period of precocious onset and accelerated maturation of click-evoked cochlear activity, specific tone stimulation triggered an altered evoked activity as soon as 16 days after birth with no recovery on the last recording session at 120 d ...	1984	6467012
radiation management of carcinoma of the tonsillar region.	this is a retrospective analysis of 185 patients with squamous cell carcinoma of the tonsillar region treated at the department of radiation oncology, university of maryland hospital from 1956 to 1977. all patients were treated by one of the following: (1) external beam therapy alone; or (2) combined external beam and interstitial brachytherapy. five-year disease-free survivals, for early stages (i and ii), are 100% and 73%, comparable to the other series published in the literature. however, in ...	1984	6467155
hereditary congenital goitre with thyroglobulin deficiency causing hypothyroidism.	the thyroid glands of two hypothyroid goitrous siblings aged 13 and 14 and of a 21-year-old hypothyroid goitrous female were examined. in all three patients a very high thyroid uptake of iodide was observed in the presence of a negative perchlorate discharge test. an abnormally high serum protein bound iodine (12.9-20.0 micrograms/dl) and low serum t4 concentration suggested the presence of increased serum levels of iodoalbumin. surprisingly, serum t3 levels were normal or low normal (80-220 ng/ ...	1984	6467633
uptake and metabolism of thyroid hormones by the rat foetus in early pregnancy.	pregnant rats were injected with trace amounts of [125i]thyroxine [( 125i]t4) or [125i]-tri-iodothyronine [( 125i]t3). maternal blood, organs and foetuses were removed 1 and 4 h later, homogenized and tri-chloroacetic acid added to precipitate radiolabelled iodothyronines. an hour after injecting [125i]thyroxine, 9-10 day old foetuses contained 21% of the radiolabel found in the same weight of plasma whereas by 13-14 days they contained 0.6%. an hour after injection of [125i]tri-iodothyronine, 9 ...	1984	6467839
flow-cytometric dna analysis in primary breast carcinomas and clinicopathological correlations.	flow-cytometric dna analyses of single cell nuclei were performed on nuclear suspensions prepared from biopsies of primary breast carcinomas in 638 patients. propidium-iodide-stained cell nuclei were analysed in an ortho 50-h cytofluorograph. the patients were staged by the tmn classification. sixty percent of all the patients had aneuploid primary breast carcinomas; of size t1, t2, t3, and t4 tumors, 51%, 63%, 67%, and 75% were aneuploid, respectively. the proportions of aneuploid tumors in eac ...	1984	6468179
viscerosomatic convergence onto t2-t4 spinoreticular, spinoreticular-spinothalamic, and spinothalamic tract neurons in the cat.	neurons of t2 to t4 spinal segments were antidromically activated from the medullary reticular formation and the contralateral region in or near the ventral posterior lateral nucleus of the thalamus. sixty-seven percent of the spinoreticular neurons projected to the ipsilateral, contralateral, or both ipsilateral and contralateral medullary reticular formation. in addition, 21% of the cells projected to the reticular formation and thalamus and 12% projected only to the thalamus. these cells rece ...	1984	6468579
long-standing recurrent paroxysmal supraventricular tachycardia disappearing after cystic degeneration of an episodically hypersecreting toxic adenoma of the thyroid.	a 35-year-old woman with an otherwise normal heart had been suffering from recurrent paroxysmal supraventricular tachycardia during the past 3 years. serum thyroid function tests were repeatedly normal. when a thyroid nodule became evident, a toxic adenoma was diagnosed. serum total hormone values were normal, but a few hours after the last recurrence of paroxysmal supraventricular tachycardia, total t3, free t3 and free t4 became clearly elevated. at that time hemorrhagic necrosis of the adenom ...	1984	6468814
annual variations in the plasma thyroxine level in microcebus murinus.	there is a great annual variation of plasma thyroxine (t4) in microcebus murinus. the averages range between 30 and 68 ng/ml from february to july, and fall to 6 ng/ml in november. long photoperiods seem to be the environmental factor responsible for the summer increase in plasma t4 as they are for testosterone. there is no apparent phase opposition with annual testosterone variation.	1984	6468919
effects of growth hormone and thyroxine on the relation between tibial length and the histological appearance of the proximal tibial epiphysis in snell dwarf mice.	the length of the tibia was studied in normal snell mice (+/?) and in dwarfs (dw/dw) before and after treatment with human growth hormone (hgh) and thyroxine (t4) in relation with the histometrical development of the tibial proximal epiphysis. the aim of the study was to obtain more insight in the specific role of these hormones in the process of bone growth in animals lacking several pituitary hormones, due to a autosomal recessive gene mutation called dw. in normal mice increase in length of t ...	1984	6469049
[electron microscopic studies on the morphogenesis of bacteriophage t4 head].		1984	6469195
hemoglobin concentration and aerobic work capacity in women following induced erythrocythemia.	the effect of induced erythrocythemia on hemoglobin concentration ([hb]) and aerobic work capacity was determined for nine women. cycle tests were performed at prereinfusion (t1), 2 days after a placebo infusion (t2), 2 days postreinfusion of 334 ml of red blood cells (t3), 8 days postreinfusion (t4), and 14 days postreinfusion (t5). t1 and t2 responses did not differ, negating a placebo effect. [hb] increased from 12.7 g x dl at t1 to 14.7 g x dl at t3 and then remained constant at t4 and t5. h ...	1984	6469823
thermophilic dna ligase. purification and properties of the enzyme from thermus thermophilus hb8.	thermophilic and thermostable dna ligase was purified to near homogeneity from the extract of thermus thermophilus hb8. the purified enzyme has an isoelectric point at ph 6.6 and consists of a single polypeptide of about 79,000 in molecular weight on the bases of sodium dodecyl sulfate-polyacrylamide gel electrophoresis data and an equilibrium sedimentation method. the enzyme requires divalent cations, mg2+ or mn2+, and the optimum concentration of these ions being 5-9 x 10(-3) m and 3-6 x 10(-3 ...	1984	6469954
production rates and turnover of triiodothyronine in rat-developing cerebral cortex and cerebellum. responses to hypothyroidism.	local 5'-deiodination of serum thyroxine (t4) is the main source of triiodothyronine (t3) for the brain. since we noted in previous studies that the cerebral cortex of neonatal rats tolerated marked reductions in serum t4 without biochemical hypothyroidism, we examined the in vivo t4 and t3 metabolism in that tissue and in the cerebellum of euthyroid and hypothyroid 2-wk-old rats. we also assessed the contribution of enhanced tissue t4 to t3 conversion and decreased t3 removal from the tissues t ...	1984	6470136
hypothyroidism: an early sign of vitamin a deficiency in chickens.	the effect of a marginal vitamin a deficiency on thyroid function was investigated in chicks gaining weight. this study examined the hypothesis that hypothyroidism is one of the earliest manifestations of hypovitaminosis a in chicks. day-old leghorn cockerels were fed vitamin a-adequate and deficient diets. blood vitamin a levels were reduced in the deficient chicks by 3 weeks of age. body weight gains were less in the 5-, 6-, 7- and 8-week-old a-deficient chicks than in controls. compared to co ...	1984	6470830
[changes of serum 3,5,3'-triiodothyronine (t3), thyroxine (t4), 3,3',5'-triiodothyronine (rt3) levels in patients with liver diseases. one marker for hepatic microsomal function].		1984	6471534
beneficial effect of thyroxin on recovery from toxic acute renal failure.	to determine the effect of thyroxin (t4) on the recovery from toxic acute renal failure, rats were injected, subcutaneously, with k-dichromate (15 mg/kg) and at the peak of the renal injury, each animal was given either t4 (4 micrograms/100 g body weight, i.p.) or normal saline (ns). the t4-treated rats had significantly better cin (669 +/- 35 microliter/min/100 g body weight), improved fena (0.49 +/- 0.05%) and increased uosm (835 +/- 50 mosm/kg) as compared to animals given only ns (cin 422 +/ ...	1984	6471672
[systemic evaluation of thyroid function in women and men from radioimmunoassay data].	the author presents a new variant of the integral quantitative systemic evaluation of thyroid function. its essence is as follows: the integral index of evaluation is based on the simultaneous registration of 3 thyroid indices tth, t3 and t4. the proposed method makes it possible to unravel changes in thyroid function concealed by homeostasis in women depending on the menstruation phase and reflects in a summary form by means of one figure the entire activities of the hypophyseal-thyroid system.	1984	6472073
metabolic alterations induced by chronic heat exposure in the rat: the involvement of thyroid function.	the effects of chronic exposure to high environmental temperature (34 degrees c) on t4 production rate, food-intake, growth-rate and resting metabolic rate were investigated in adult male rats. this study was designed to examine the extent of variations and possible relationships between these parameters. as compared to control rats of the same body weight kept at 25 degrees c, rats exposed to 34 degrees c for 3-4 weeks exhibited a retarded growth-rate: 2.3 vs 4.0 g/day, a reduced food-intake: 1 ...	1984	6473066
the bacteriophage t4 rega gene: primary sequence of a translational repressor.	the rega gene product of bacteriophage t4 is an autogenously controlled translational regulatory protein that plays a role in differential inhibition (translational repression) of a subpopulation of t4-encoded "early" mrna species. the structural gene for this polypeptide maps within a cluster of phage dna replication genes, (genes 45-44-62-rega-43-42), all but one of which (gene 43) are under rega-mediated translational control. we have cloned the t4 rega gene, determined its nucleotide sequenc ...	1984	6473098
[t4 thyrotoxicosis].		1984	6473209
[role of the thyroid hormone in the functioning of the hypophyseal-adrenal-gonad system of rabbits].	the influence of a long-term t4 injection on the gonadal and adrenal androgenic function as well as on the hypophyseal gonadotropic activity was studied in experiments on adult male rabbits, using histological and hormonal methods. it was shown that in rabbits with experimental moderate thyroxin toxicosis the testicular testosterone secretion is inhibited, whereas the adrenal testosterone secretion is compensatory enhanced. the level of hypophyseal gonadotropins tends to rise. the prostatic weig ...	1984	6473317
effects of dietary thyroid hormones on growth and serum t3, t4, and growth hormone in sex-linked dwarf chickens.	dwarf pullets fed with either t3 or t4 at 0.1, 1.0, and 10.0 ppm for 2 weeks showed no improvement in their body weight gain as compared with birds that were fed a control diet. birds fed t3 or t4 at 10.0 ppm showed poorer growth, body weight gain, and feed efficiency than control birds. pullets fed 1.0 ppm of t3 showed significantly better feed efficiency than control birds. serum t3 concentrations were significantly higher when birds were fed 1.0 ppm of t3 or 10.0 ppm of t3 or t4. plasma t4 co ...	1984	6473357
effects of triiodothyronine treatments on body and organ growth and the development of immune function in dwarf chickens.	the effects of triiodothyronine (t3) treatments on general body growth, long bone growth, primary lymphoid organ development, antibody production, and serum growth hormone (gh) and thyroid hormone levels were examined in two dwarf strains (sex-linked dwarf--sld, and autosomal dwarf--adw) and in a normal-growing control strain (k) of white leghorn chickens. one-day-old male chicks from each of these strains were assigned to either an untreated control group or to one of the groups receiving a t3 ...	1984	6473358
roles of copper and o(2) in the radiation-induced inactivation of t7 bacteriophage.	the effect of copper on the radiation damage induced in t7 bacteriophage has been investigated. the phages were gamma-irradiated and the effects of copper(ii) ions in the presence of various additives and radical scavengers were examined in an attempt to better understand the effect of transition metal ions on the role of free radicals, particularly superoxide, in biological damage. the present work extends a study previously done on isolated enzyme to a whole biological entity. copper(ii) ions ...	1984	6473714
[determination of thyroxine in serum by magic-t4 kit].		1984	6473843
[thyroxine (t4) to 3,5,3'-triiodothyronine (t3) and 3,3',5'-triiodothyronine (reverse t3) conversion in human leukocyte suspensions. study in hyper and hypothyroidism states].		1984	6474031
synthesis of the leu-enkephalin gene.	the synthesis of leu-enkephalin gene by an alternative approach was described in this paper. the sequence of the synthetic gene, 26 base-pairs in length, was derived from the amino acid sequence of the hormone peptide leu-enkephalin. it bears single-stranded cohesive termini for the restriction endonucleases ecor i and bamh i so that it may be inserted into a pbr 322 plasmid. the 4 deoxyoligonucleotide fragments, varying in length from octanucleotide to octadecanucleotide, were synthesized by an ...	1984	6474152
magnetic antibody immunoassay thyroid function tests in general practice.	commercial radioimmunoassay kits for the measurement of human total thyroxine (t4) and total triiodothyronine (t3) based on magnetic separation are discussed for use in dogs and cats. the t4 assay procedure is modified to increase the accuracy over normal canine and feline ranges using four standards from kit components provided. results of validation are presented and indicative normal ranges given: canine t4, 0.94 to 3.45 micrograms/dl; canine t3, 0.36 to 1.52 ng/ml; feline t4, 1.34 to 4.70 mi ...	1984	6474779
[follow-up of patients with differentiated thyroid cancer: determination of serum thyroglobulin in place of routine 131i scintigraphy?].	a comparison was conducted in patients with differentiated thyroid carcinoma still under 131i therapy (n = 18) between 2 mci-131i scans, posttherapeutic scans and radioimmunologically measurable serum thyroglobulin (tg). all 3 parameters were positive in only 9 cases; among the other 9 patients tg appeared to be the better indicator (ratio 5:1) of residual tumour tissue than the 2 mci-131i scan. in a second group of patients who had completed 131i therapy the 2 mci scan and tg were compared (n = ...	1984	6475061
[the effect of amiodarone on thyroid gland function].	plasma concentrations of t4, ft4, t3, rt3 and tbg, as well as of tsh before and after stimulation with trh were studied in 25 patients, who had been treated with amiodarone for up to nine years. at the beginning of therapy, all the parameters mentioned above were found to be in the normal range in all patients. after two months of therapy, t4 had increased from 100 nmol/l +/- 24 nmol/l to 155 nmol/l +/- 32 nmol/l (p less than 0.01), and ft4 from 22 pmol/l +/- 10.5 pmol/l to 32 pmol/l +/- 8 pmol/ ...	1984	6475180
pseudotumor cerebri following treatment of hypothalamic and primary hypothyroidism.	pseudotumor cerebri occurs in many diverse endocrine and nonendocrine disorders. we report what we believe is a new association following initiation of thyroxine (t4) replacement in hypothalamic hypothyroidism, as well as another occurrence following t4 replacement in primary hypothyroidism. the less than benign clinical course reported in these two patients suggests the need for careful neurologic and funduscopic evaluation during the initial months of t4 replacement in all cases of hypothyroid ...	1984	6475854
[primary chemotherapy in breast cancer. preliminary results].	primary chemotherapy in carcinoma of the breast is justified by the high risk of distant metastases, immunodepression related to surgery and the experimental studies and clinical trials of nissen-meyer in 1967, and fisher in 1968. chemotherapy was associated with loco-regional patey-type surgery (20 patients) or radiotherapy with cobalt and irridium (43 patients) in 63 cases of breast cancer, 33 of which were t4 or in exarcerbation. initial chemotherapy comprised 3 to 6 infusions of velbe, thiot ...	1984	6476666