Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| surface markers and cytotoxic activity of blood natural killer cells studied at the single cell level in hodgkin's disease. | purified peripheral blood lymphocytes (pbl) from nine untreated patients with hodgkin's disease (hd), two hd patients in complete remission and 17 healthy donors were studied for natural killer (nk) cell activity against the k-562 cell line using a single cell cytotoxic assay, which allowed enumeration of effector cells and characterization of their surface membrane phenotypes after staining with monoclonal antibodies. the frequency of nk cells was significantly lower in hd patients than in cont ... | 1985 | 4042422 |
| evidence for induction by thyroid hormone of cytosolic proteins which control mitochondrial protein synthesis. | the effect of thyroid hormone on the generation of modulators of mitochondrial protein synthesis was investigated. the modulators were present in the 150,000 x g supernatant (s-150) prepared from wistar rat liver and kidney. in young rats (50 g bw), a stimulator was found in liver, and an inhibitory modulator was present in kidney tissue. generation of these modulators was stimulated by t4 administration to the animals. in aged rats (200 g bw), the production of an inhibitory modulator in both l ... | 1985 | 4042962 |
| abnormal thyroid hormone binding to serum proteins in ob/ob and db/db genetically obese mice. | sera from ob/ob and db/db genetically obese mice exhibited abnormal nonspecific (no antibody present) binding measurements in t4 and t3 rias employing dextran-charcoal separations. they also showed decreased charcoal uptake compared to sera of lean controls in a conventional charcoal t4 uptake binding test. after correction for the abnormal nonspecific binding and after extraction of serum, mean serum t4 concentrations were similar in control and ob/ob mice. mean serum t3 concentrations differed ... | 1985 | 4042966 |
| cholera toxin treatment increases in vivo growth and development of the mouse mammary gland. | daily sc injections of cholera toxin (ct; 0.1 micrograms/day), a stimulator of adenylate cyclase activity, into intact female balb/c mice for 20 days significantly (p less than 0.05) increased mammary gland development scores from 2.0 +/- 0.1 in controls to 3.6 +/- 0.2 in ct-treated mice. concurrent administration of 17 beta-estradiol (e; 1.0 microgram/day) and progesterone (p; 1.0 mg/day) resulted in development scores of 4.1 +/- 0.1 and 5.2 +/- 0.1 in e/p and e/p + ct treatment groups, respect ... | 1985 | 4042967 |
| effects of maternal hypothyroidism on the weight and thyroid hormone content of rat embryonic tissues, before and after onset of fetal thyroid function. | embryonic tissues were obtained from normal (c) and thyroidectomized (t) rats between 9 and 21 days of pregnancy. we determined the number and weight, as well as the t4 and t3 contents (ria), of 9- to 12-day-old embryotrophoblasts, of 13- to 21-day-old embryos and placentas, and of liver, lung, and brain from 20- and 21-day-old fetuses. t4 and t3 were found in all samples obtained from c dams, both before and after onset of fetal thyroid function. despite low levels of both iodothyronines in fet ... | 1985 | 4042969 |
| skin is an active site for the inner ring monodeiodination of thyroxine to 3,3',5'-triiodothyronine. | t4 (0.26 microm) was incubated in 0.1 m phosphate buffer (ph 7.4) containing 10 mm edta with homogenates (3-5 mg protein) of various rat tissues and up to 400 mm dithiothreitol (dtt) for 1 h at 37 c; the rt3 generated was measured by ria of ethanol extracts of the incubation mixture. among the various tissues of the male rat, homogenates of skin and cerebral cortex were very active in the conversion of t4 to rt3; other tissues demonstrated little or no t4 5-monodeiodinating activity (ma). the ti ... | 1985 | 4042977 |
| thyroidal thyroxine and triiodothyronine in autonomously functioning thyroid nodule and paranodular tissue. | thyroidal thyroxine (t4), triiodothyronine (t3), thyroglobulin (tg) and t4/t3 ratio were investigated in nodular and paranodular tissue from 16 patients with autonomously functioning thyroid adenomas. the concentration of t4 and t3 in the nodule were 97.7 +/- 20.5 (mean +/- se) and 10.2 +/- 2.4 micrograms/g wet weight (w.w.). both iodothyronines were significantly lower in paranodular tissue (22.6 +/- 4.8 and 1.45 +/- 0.32 micrograms/g w.w., respectively), but with disproportionately decreased t ... | 1985 | 4043239 |
| differential effects of thyroxine on immune development and autoimmune thyroiditis in the obese strain chicken. | the effects of dietary thyroxine (t4) supplementation for specific periods on the early development of the primary lymphoid organs and spontaneous autoimmune thyroiditis (sat) was examined in the obese (os) strain of chicken. effects of the treatments on concentrations of serum growth hormone (gh) and testosterone were also determined. all treatment groups were examined at 6 weeks. t4 supplementation did not affect serum testosterone or gh concentrations. however t4 given for the first three wee ... | 1985 | 4043483 |
| effects of clo2 on the absorption and distribution of dietary iodide in the rat. | aqueous chlorine dioxide (clo2), an alternative disinfectant for drinking water, was found to decrease gastrointestinal (gi) bioavailability of dietary iodide. it has been previously reported that subchronic exposure to clo2 decreases thyroxine (t4) levels in nonhuman primates. in this study in vitro experiments with animal feed, isolated rat stomachs, as well as in vivo studies with intact rats, showed that clo2 in drinking water (at in situ concentrations as low as 2 ppm) oxidizes iodide to it ... | 1985 | 4043591 |
| thyroid indices in panic disorder. | eighty-two patients suffering from panic attacks with or without phobias were examined for evidence of thyroid disease. none of the patients had abnormal total t4 or t3 resin uptake measurements, regardless of whether they were nonmedicated or treated with one of three antipanic drugs: alprazolam, phenelzine, or imipramine. a higher than expected incidence of undetectable tsh levels (22% overall) appeared in all groups. the clinical relevance of this finding is currently uncertain. | 1985 | 4044534 |
| overlap of segmental populations and axon collaterals in the thoracic sympathetic system of the cat. | sympathetic preganglionic axons are known to branch in the sympathetic chain, i.e. extraspinally. the possibility that the axons may branch within the spinal cord (intraspinally) and exit through different roots has not been well examined. the purpose of this study was to determine if intraspinal collaterals exist in the distribution of preganglionic neurons innervating the stellate ganglion of the cat using the double-labeled retrograde fluorescent dye technique (diamidino yellow and fast blue) ... | 1985 | 4045101 |
| partial restoration of cerebral myelination of the congenitally hypothyroid mouse by parenteral or breast milk administration of thyroxine. | we attempted to define whether thyroid hormone can ameliorate the cerebral hypomyelination present in the congenitally hypothyroid (hyt) neonatal mouse, and to define the critical time period during early postnatal life when thyroxine (t4) is essential for myelin formation. we administered t4 to the hyt mouse by breast milk during the first 20 days of postnatal life, and through the diet during the second 20 days of postnatal life. positive results were obtained only when hormone was given durin ... | 1985 | 4045455 |
| structure of phage p22 gene 19 lysozyme inferred from its homology with phage t4 lysozyme. implications for lysozyme evolution. | the amino acid sequence of the lysozyme from phage p22 is shown to be homologous (26% identity) with the lysozyme from bacteriophage t4. the sequence correspondence suggests that the structure of p22 lysozyme is similar to the known structure of t4 lysozyme within the "core" of the molecule, including the active site cleft. however, p22 lysozyme appears to lack two surface loops present in t4 lysozyme. it is possible that p22 lysozyme may provide an "evolutionary link" between the phage-type lys ... | 1985 | 4046032 |
| initiation of transcription by bacteriophage t4-modified rna polymerase independently of host sigma factor. | after infection of escherichia coli with bacteriophage t4 a series of modifications of rna polymerase takes place including the association of several small polypeptides. we isolated rna polymerase from cells abortively infected with a series of t4 mutants which arrest phage development at different stages and found that different sets of associated proteins are present in rna polymerase in each case. the patterns of associated polypeptides seem to correlate with dna content in the infected cell ... | 1985 | 4046041 |
| reduced serum t4 and t3 and their altered serum binding after burn injury in rats. | total t4 and t3 concentrations are often suppressed in burned patients. to investigate the significance of such changes, we have characterized serum t4 and t3 after full-thickness scald burns (60% body surface under anesthesia) of 270-gm male sprague-dawley rats housed in a light:dark cycle of 14:10 hr. groups (n = 9-15) of burn, sham (anesthesia, fur clipped, no burn) and con (controls) were sacrificed on postburn days 8 and 14. t4 and t3 (radioimmunoassay), free indices (ft4i and ft3i = respec ... | 1985 | 4046084 |
| [operative indications and surgical procedure in iodine-induced hyperthyroidism]. | clinical course, indications for surgical treatment, and results of treatment in 8 female patients with iodine induced thyrotoxicosis (iit) are reported. the diagnosis of iit could be established in all patients by a) clinical hyperthyroidism, b) increased t3 and t4 serum concentrations, and c) previous iodine contamination. sources of iodine were radiographic contrast agents for urography (n = 4), oral cholecystography (n = 3), intravenous cholangiography (n = 1), phlebography (n = 1), and cran ... | 1985 | 4046686 |
| effects of exercise and physical fitness on the pituitary-thyroid axis and on prolactin secretion in male runners. | the effects of acute exercise and thyrotropin-releasing hormone on the pituitary-thyroid axis were examined in men placed into three well-defined categories of physical fitness. there were 20 sedentary men, 22 joggers (running four to 20 miles per week) and 18 marathoners (running 30 to 100 miles per week) who participated. during treadmill exercise, the mean vo2 max differed among all groups, being 38.5, 45.0, and 60.3 ml/kg . min in the sedentary, jogger, and marathon groups, respectively. ser ... | 1985 | 4046839 |
| [therapy of juvenile struma. comparison between combination treatment and monotherapy]. | 91 children (70 girls and 21 boys) aged between 5 and 16 years were treated orally with thyroid hormones for euthyroid juvenile goiter. maximally for 54 months. 16.5% of the children had a goiter size i, 69.2% size ii, and 14.3% size iii. 59 patients were treated for an average of 15.3 months with a mean daily dose of 90.9 micrograms thyroxine (t4) plus 18.2 micrograms triiodothyronine (t3) per m2 body surface. 32 patients received t4 in a mean daily dose of 88 micrograms/m2 body surface for an ... | 1985 | 4047068 |
| formation and persistence of sterigmatocystin--dna adducts in rat liver determined via 32p-postlabeling analysis. | a 32p-postlabeling method has been employed to detect the in vitro and in vivo modification of dna by the mycotoxin sterigmatocystin (st). st-modified dna was initially incubated under buffered alkaline conditions to convert unstable st-n7-guanine moieties to stable, putative st-formamidopyrimidine derivatives. dna was subsequently digested with micrococcal nuclease and spleen phosphodiesterase, and the resulting st-modified nucleotides, purified by reverse-phase thin-layer chromatography (tlc), ... | 1985 | 4047087 |
| labeled corticospinal neurons one year after spinal cord transection. | one year after a t9 spinal cord transection, horseradish peroxidase was inserted into the spinal cord at t3-t4. only about 7% of the number of corticospinal neurons labeled in control rats were labeled in exactly matched transected rats. this long-term loss of labeled neurons makes cell death the most likely explanation for the failure to identify corticospinal neurons in spinal-cord-transected rats. | 1985 | 4047489 |
| indications for performing hemithyroidectomy for tumors requiring total laryngectomy. | to determine the necessity of performing a hemithyroidectomy in patients who require a total laryngectomy, the pathologic reports and clinical courses of 261 patients who underwent total laryngectomy were reviewed. twenty-four percent of the specimens demonstrated transcartilaginous invasion, with the highest incidences occurring in glottic (31 percent) and subglottic (60 percent) tumors. epidermoid tumor invading the thyroid gland occurred in 5 percent of the specimens. all of these showed inva ... | 1985 | 4051106 |
| cyclical eosinophilia: a manifestation of periodic haemopoiesis? | a patient is described who has had a marked eosinophilia of unknown cause for 9 years in association with episodic facial swelling. weekly blood counts for 8 months showed cyclical variations in eosinophils, neutrophils and monocytes (mean cycle length 35 d). marrow culture studies showed fluctuation in the incidence of granulocyte-macrophage colonies (gm-cfc), and the proportion of eosinophil colonies was higher than the values reported for normals. the blood lymphocyte t4/t8 ratio was reversed ... | 1985 | 4052333 |
| characteristics of the binding of the anticancer agents mitoxantrone and ametantrone and related structures to deoxyribonucleic acids. | the binding constants for interaction of the anticancer agents mitoxantrone and ametantrone and several congeners with calf thymus dna and the effects of ionic strength changes have been determined spectrophotometrically. the agents show a preference for certain sequences, particularly those with gc base pairs, and the magnitude of the specificity depends on the specific substituents on the anthraquinone ring system. the binding constant for mitoxantrone with calf thymus dna in 0.1 m na+, ph 7, ... | 1985 | 4052381 |
| enhanced sensitivity of 32p-postlabeling analysis of aromatic carcinogen:dna adducts. | we have previously described a 32p assay for the detection and quantitation of aromatic carcinogen:dna adducts (r. c. gupta et al., carcinogenesis (lond.), 3: 1081-1092, 1982). the method entails enzymatic digestion of dna to deoxynucleoside 3'-monophosphates which are then converted to deoxynucleoside 3',5'-[5'-32p]diphosphates by t4 polynucleotide kinase-catalyzed 32p transfer from adenosine [gamma-32p]triphosphate. labeled adducts are purified and resolved by four-directional thin-layer chrom ... | 1985 | 4053037 |
| free thyroxin measured in dried blood spots: results for 10 000 euthyroid and 29 hypothyroid newborns. | we measured free thyroxin (ft4) in dried blood samples from 10 000 euthyroid and 29 hypothyroid newborns (three with transient hypothyroidism and 26 permanent). in euthyroids, the mean ft4 concentration was 16.9 (sd 4.5) pmol/l. preterm babies had low concentrations of ft4, and values were closely related to birth weight when less than 2500 g. assay of blood-spot ft4 appears to be specific as a test for hypothyroidism screening, yielding 0.42% false positives when a mean minus 2 sd cutoff value ... | 1985 | 4053352 |
| spontaneous autoimmune thyroiditis in obese strain chickens: a genetic analysis of target organ abnormalities. | in this study we investigated the genetic background of primary abnormalities found in the thyroid gland of obese strain (os) chickens with spontaneous autoimmune thyroiditis (sat), i.e., susceptibility to passively transferred antibodies to thyroglobulin (tgab) and incomplete suppression of iodine uptake by thyroxine (t4). several crosses between the b15/b15 subline of os chickens and the inbred cb line (b12/b12) were done and the progeny was analyzed for thyroiditis after injection of os serum ... | 1985 | 4053427 |
| retarded skeletal maturation in children with primary enuresis. | primary nocturnal enuresis (pne) is a common paediatric problem of multifactorial aetiology. growth and skeletal maturation were studied in 35 otherwise healthy children with pne, 26 boys and 9 girls aged 6-14 years, and comparison was made with a control (ctr) group of 19 boys and 3 girls aged 6-13 years of similar ethnic origin. there was no significant difference between the mean height and weight centiles of the two groups. bone age (ba) determined by the tw-2 method showed a significant lag ... | 1985 | 4054161 |
| circulating thyroid hormone concentrations in relation to seasonal events in the male indian garden lizard, calotes versicolor. | circulating thyroxine (t4) and triiodothyronine (t3) were estimated by ria in plasma samples of calotes versicolor collected over a period of 28 months. monthly observations on seasonal events, viz., molting, whole body o2 consumption, abdominal fat deposition, and testes weight were also made. plasma t4 ranged from 0.16 to 4.63 ng/ml and t3 from 0 to 1.76 ng/ml during the course of the year. peaks of t4 and t3 could be related with prehibernating (october/november) and posthibernating (march/ap ... | 1985 | 4054585 |
| serum concentrations of total t4, t3, reverse t3 and free t4, t3 in moderately obese patients. | serum total thyroxine (t4), 3,5,3'-triiodo-l-thyronine (t3), 3,3',5'-triiodo-l-thyronine (reverse t3 or rt3) and free thyroxine (ft4), free 3,5,3'-triiodo-l-thyronine (ft3) concentrations were measured by radioimmunoassay in 52 moderately obese patients and 32 age-matched control subjects with constant body weight and no dietary restriction. the comparisons of iodothyronine concentrations in the obese and control subjects gave the following results: serum t4 and ft4 concentrations were not diffe ... | 1985 | 4055428 |
| relationship between lymph nodal status and primary tumor control probability in tumors of the supraglottic larynx. | a retrospective review of 248 patients with squamous cell carcinoma of the supraglottic larynx was undertaken to determine the relationship between the probability of control of the primary lesion, the extent of neck nodal disease at initial presentation, and its ultimate control. all patients were treated at the u.t. m. d. anderson hospital between 1960 and 1980, and had a minimum of 3 years follow-up. the primary lesion was staged t1 in 38 patients, t2 in 132, t3 in 50 and t4 in 28. the initia ... | 1985 | 4055449 |
| thyrotropin stimulation test--new perspective on value of monitoring triiodothyronine. | thyrotropin (thyroid stimulating hormone; tsh) stimulus to thyroid cells of horses and dogs resulted in increased serum triiodothyronine (t3) concentrations that were detected earlier than those of thyroxine (t4). doubling of the base-line t3 values in horses was detected 0.5 hours after injection of 5 iu of tsh iv, with peak response of 5 times base-line value detected 2 hours after injection. doubling of t4 values in horses was noticed between 2 and 3 hours, with the peak response of 2.4 times ... | 1985 | 4055518 |
| the effects of phenytoin (diphenylhydantoin) on the extrathyroidal turnover of thyroxine, 3,5,3'-triiodothyronine, 3,3',5'-triiodothyronine, and 3',5'-diiodothyronine in man. | the extrathyroidal metabolism of t4, t3, rt3, and 3',5'-diiodothyronine (3',5'-t2) was studied before and after treatment with 350 mg phenytoin (dph) daily for 14 days in six hypothyroid patients receiving constant l-t4 replacement. the total and free serum concentrations of the four iodothyronines were reduced by approximately 30% during dph treatment, whereas the free fractions in serum were unaltered. concomitantly, serum tsh increased 137% (p less than 0.02). the production rate (pr) of t4 d ... | 1985 | 4055984 |
| in vivo stimulation of sugar uptake in rat thymocytes. an extranuclear action of 3,5,3'-triiodothyronine. | in previous studies we have demonstrated that 3,5,3'-triiodothyronine (t3) in vitro produces a prompt increase in the uptake of the sugar analogue 2-deoxyglucose (2-dg) by freshly isolated rat thymocytes. this effect is prompt, being evident at 20 min after addition of t3, is independent of new protein synthesis, and can be elicited by physiologic concentrations of the hormone. in the present studies, we have sought to determine whether physiologic doses of t3 are capable of inducing an increase ... | 1985 | 4056041 |
| a prospective evaluation of 5-fluorouracil plus cisplatin in advanced squamous-cell cancer of the head and neck. | recent studies have shown improved efficacy of chemotherapy in patients with advanced squamous-cell cancer of the head and neck. our purpose was to evaluate prospectively the activity of cisplatin plus 5-fluorouracil (5fu) in 37 patients with advanced stage iv squamous-cell cancer of the head and neck. there were two groups. group 1 consisted of 19 previously untreated patients with either t4 or n3 disease. they received 100 mg/m2 cisplatin (days 1 and 28) and 120-hour infusion of 1,000 mg/m2/24 ... | 1985 | 4056841 |
| energy intake, weight gain and fat deposition in rats fed flavored, nutritionally controlled diets in a multichoice ("cafeteria") design. | the effect of flavor variety on diet selection, energy intake, weight gain and fat deposition was studied in male rats fed flavored, nutritionally controlled, purified diets in a multichoice "cafeteria" (caf) arrangement. serum insulin, l-3,3',5-triiodothyronine (t3) and thyroxine (t4) levels were also determined. rats fed nutritionally balanced diets containing a variety of preferred flavors and textural forms ad libitum in a caf design did not consume more energy nor did they gain more weight ... | 1985 | 4056941 |
| sequence organization and control of transcription in the bacteriophage t4 trna region. | bacteriophage t4 contains genes for eight transfer rnas and two stable rnas of unknown function. these are found in two clusters at 70 x 10(3) base-pairs on the t4 genetic map. to understand the control of transcription in this region we have completed the sequencing of 5000 base-pairs in this region. the sequence contains a part of gene 3, gene 1, gene 57, internal protein i, the trna genes and five open reading frames which most likely code for heretofore unidentified proteins. we have used su ... | 1985 | 4057254 |
| dna packaging of bacteriophage t4 proheads in vitro. evidence that prohead expansion is not coupled to dna packaging. | we developed a system for dna packaging of isolated bacteriophage t4 proheads in vitro and studied the role of prohead expansion in dna packaging. biologically active proheads have been purified from a number of packaging-deficient mutant extracts. the cleaved mature prohead is the active structural precursor for the dna packaging reaction. packaging of proheads requires atp, mg2+ and spermidine, and is stimulated by polyethylene glycol and dextran. predominantly expanded proheads (elps) are pro ... | 1985 | 4057255 |
| the cause of low voltage qrs complex in primary hypothyroidism. pericardial effusion or thyroid hormone deficiency? | in order to clarify the cause of low voltage qrs complex seen on ecg (low voltage), thyroid hormones, ldh isozyme and pericardial effusion (pe) were studied in 39 patients with primary hypothyroidism. low voltage and pe were found in 12 of 39 (30.8%) and 12 of 27 (44.4%), respectively. serum t4 in patients with low voltage (group 1) was significantly lower than that in patients without low voltage (group 2) (t4 1.4 +/- 1.7 vs 2.8 +/- 2.3 micrograms/dl, p less than 0.05). group 1 had a higher inc ... | 1985 | 4057554 |
| [thyroid hormone content of the blood plasma and functional state of the myocardium in patients with chronic forms of ischemic heart disease]. | sixty-seven patients with angiographically-confirmed coronary heart disease (chd) were investigated. three patterns of thyroid hormone (t3 and t4) response to exercise were identified: rising, falling and unchanged levels. coronary patients with rising t3 levels in response to exercise typically showed smaller left-ventricular ejection values as compared to those patients whose t3 levels declined. coronary patients with low baseline t3 tended to have elevated left-ventricular end diastolic press ... | 1985 | 4057749 |
| radiation-induced thyroid disease. | ionizing radiation has been demonstrated to result in a number of changes in the human thyroid gland. at lower radiation dose levels (between 10 and 1500 rads), benign and malignant neoplasms appear to be the dominant effect, whereas at higher dose levels functional changes and thyroiditis become more prevalent. in all instances, the likelihood of the effect is related to the amount and type of radiation exposure, time since exposure, and host factors such as age, sex, and heredity. the author's ... | 1985 | 4058093 |
| effect of tsh on conversion of t4 to t3 in perfused rat kidney. | this study was undertaken to elucidate the effect of thyrotropin (tsh) on the conversion of thyroxine (t4) to 3,5,3'-triiodothyronine (t3) in the isolated perfused rat kidney. the kidney was perfused with a synthetic medium containing 20 micrograms/dl t4 and the effect of constant infusion of bovine tsh (125 or 250 microu/ml) on the conversion of t4 to t3 was investigated. t4 uptake in the perfused kidney was not changed by the addition of tsh. however, the release of t3 (89 +/- 11 ng/g/30 min, ... | 1985 | 4058310 |
| [importance of thyroid hormone determination in the diagnosis of hyperthyroidism--significant improvement in medical assessment using decision theory results]. | a "schematic" classification of the results of serum thyroid hormone measurements on the basis of mathematical decision theory proves to be superior to the physicians' conventional evaluation. that has been shown by comparison with the evaluations made by three experienced doctors. when using no control regions (but the results of serum t4, ft4 and t3 simultaneously) the physicians' rates of misrecognition (0-2% false positives, 20-27% false negatives) are only a little lower than when classifyi ... | 1985 | 4059064 |
| [reaction of the thyroid gland to a single and prolonged administration of prolactin]. | a study was made of the thyroid and hypophysis response to the administration of a summary analogous dose of prolactin injected in a single dose or in the course of 5 days. experiments were made on female rats at the diestrus stage. the content of thyroid hormones and thyrotropic hormone (tth) in the blood was determined by radioimmunoassay. the concentration of thyroid hormones and tth was compared in the basal state and 30, 60, 120 and 180 min after prolactin injection. an acute prolactin admi ... | 1985 | 4059197 |
| early changes in the levels of serum triiodothyronine (t3), thyroxine (t4), t3/t4 ratio and microsomal carboxylesterase activity in rats following treatment with ccl4. | to study the relationship between the activity of nonspecific carboxylesterase located in the smooth endoplasmic reticulum (ser) of hepatocytes, and serum thyroid hormones including triiodothyronine (t3), thyroxine (t4), and t3/t4 ratio, we determined these hormones, liver carboxylesterase activity, and serum alanine amino-transferase (sgpt) before, and 5 to 720 min after treatment with a single oral dose of cc14 (1 ml/kg) in rats. the serum t3/t4 ratio decreased 5 to 10 min after administration ... | 1985 | 4059658 |
| inappropriate thyroid-stimulating hormone release in the elderly? | in three hyperthyroid women aged more than 60 years serum tsh levels, inhibited as usual before treatment, rose and remained elevated for more than one year while on treatment with methimazole and l-thyroxine, in spite of serum t3 and t4 levels within the normal range. in two hypothyroid women aged more than 60 years, serum tsh levels, raised under basal conditions, failed to be suppressed by a one-year treatment with l-thyroxine. repeated attempts to increase serum t3 and t4 concentrations by g ... | 1985 | 4059798 |
| post-operative analgesia by epidural versus intramuscular nicomorphine after thoracotomy. part i. | one hundred and sixty-three patients subjected to three different types of thoracic operation were allocated randomly either to balanced intravenous anaesthesia including i.v. opiates with post-operative intramuscular opiates (intramuscular group) or to balanced intravenous anaesthesia without i.v. opiates but with high thoracic epidural regional block during the operation as well as epidural nicomorphine post-operatively (epidural group). post-operative nicomorphine was given only at the reques ... | 1985 | 4060998 |
| ultrastructural markers in circulating lymphocytes of subjects at risk for aids. | one hundred random lymphocytes in each of 168 buffy coat preparations from 59 subjects at risk for aids (50 homosexuals, 7 hemophiliacs, and 2 combined, all with t4:t8 ratios of less than or equal to 1.2) were screened for the presence of ultrastructural markers, "tubuloreticular structures" (trs), and "test tube and ring-shaped forms" (trf). twenty-six (44%) of the subjects were trs positive (71 specimens) and 12 (20%) were trs/trf positive (34 specimens). trf were only observed in trs-positive ... | 1985 | 4061383 |
| meal-induced brown fat thermogenesis and thyroid hormone metabolism in rats. | the relationship between the meal-induced increase in brown adipose tissue (bat) thermogenesis, determined by the level of gdp binding to bat mitochondria, and thyroid hormone metabolism have been examined. a single low-protein, high-carbohydrate meal resulted in a significant increase in the thermogenic activity of bat. this effect on bat thermogenesis was accompanied by significant increases in activity of thyroxine 5'-monodeiodinase in the bat (p less than 0.05) and liver (p less than 0.02) b ... | 1985 | 4061641 |
| peridural anesthesia and the distribution of blood in supine humans. | to determine the effects of vasomotor tone on intrathoracic and splanchnic blood volume, the distribution of radioactively (99mtc) labeled erythrocytes was recorded by whole body scintigraphy before and during peridural anesthesia (pda) in eight supine men. the radioactivity was recorded with a gamma camera and its distribution determined in the thorax, abdomen, and limbs. arterial and central venous pressure, heart rate, and calf volume and flow also were measured. during pda with a sensory blo ... | 1985 | 4061917 |
| clinical value of a sensitive immunoradiometric assay for tsh. | we have investigated a sensitive immunoradiometric assay for serum thyroid-stimulating hormone (tsh) in 45 thyrotoxic patients not on treatment, 464 euthyroid patients and 111 hypothyroid patients on replacement therapy. forty-three thyrotoxic and seven euthyroid patients were found to have an undetectable tsh (less than 0.2 miu/l). previous work has shown a very clear separation of thyrotoxic and euthyroid patients using sensitive tsh assays. however, our extended study here has revealed that a ... | 1985 | 4062219 |
| three-dimensional structure of goose-type lysozyme from the egg white of the australian black swan, cygnus atratus. | the egg white of c. atratus contains two forms of lysozyme, a 'chick-type' which is similar to that found in the egg white of the domestic hen, and a 'goose-type' similar to that found in the egg white of the embden goose. the molecular structure of the goose-type lysozyme has been determined at a resolution of a 2.8 a by x-ray crystallographic analysis. the structure consists of two domains linked by a long stretch of alpha-helix. in all, there are seven helical segments in the structure. while ... | 1985 | 4062692 |
| endocrine regulation of metabolism in sheep given kale (brassica oleracea) and ryegrass (lolium perenne)-clover (trifolium repens) fresh-forage diets. | diets of fresh kale (brassica oleracea) and ryegrass (lolium perenne)-clover (trifolium repens) herbage were fed to growing sheep in three experiments. in expts 1 and 3 the sheep were confined indoors and fed at hourly intervals, and all were given supplementary iodine to counteract kale goitrogens. lambs grazed the two forages for 24 weeks in expt 2, with and without intramuscular injections of iodized oil. the kale and herbage contained respectively 11 and less than 0.1 g s-methyl-l-cysteine s ... | 1985 | 4063301 |
| potentiation of thyroxine 5-deiodination by aminotriazole. | aminotriazole, a goitrogen, in addition to its known inhibitory effects on the thyroid, demonstrated a unique effect on peripheral deiodination of thyroxine (t4). in contrast to the well-known peripheral effects of goitrogens such as propylthiouracil in inhibiting 5'-deiodinase activity, i.e., to effect a decrease in t4 to triiodothyronine (t3) conversion, aminotriazole had no effect on the 5'-deiodinative pathway. rather, this goitrogen appeared to stimulate the alternative pathway, viz. t4 5-d ... | 1985 | 4063388 |
| [functional state of the thyroid gland during systemic graft vs host reaction]. | triiodothyronine (t3), thyroxine (t4) and thyroid stimulating hormone (tsh) serum content was measured in mice during systemic "graft-versus-host" reaction (gvhr), using radioimmunoassay. it was demonstrated that on the 3rd day after gvhr induction the levels of these hormones did not differ from the control values. t3 and t4 concentrations and 125i absorption by thyroid gland diminished by day 10. at the same time tsh level remained unchanged. on day 24 after gvhr induction t3 and t4 content wa ... | 1985 | 4063510 |
| increased frequency of goitre in epileptic patients on long-term phenytoin or carbamazepine treatment. | thyroid function, the clinical occurrence of goitre and ultrasonically determined thyroid gland volume were investigated in 23 patients with phenytoin- and 28 patients with carbamazepine-treated convulsive disorders and compared with matched healthy controls. in the phenytoin treated group median thyroid volume was 26 ml (range 14-57 ml) compared to 17 ml (range 8-41 ml) in the controls (p less than 0.01). ten patients and four controls had a goitre (ns). median serum t4 and ft4i levels were red ... | 1985 | 4064350 |
| effect of aminoglycosides on the disposition of thyroid hormones and thyroglobulin. | our study was designed to confirm the potential effects of three aminoglycosides on the disposition of thyroid hormones. twenty-seven patients diagnosed with either cellulitis (n = 19), chronic osteitis (n = 4), or an abscess (n = 4) were selected. thirteen patients received tobramycin, 60 to 100 mg iv q. 8 h., plus cloxacillin, 1 gm iv q. 4 h.; seven patients received netilmicin, 40 to 120 mg iv q. 8 h., plus cloxacillin, 1 gm iv q. 4 h.; and seven patients received either cloxacillin, 1.5 gm i ... | 1985 | 4064470 |
| bone scintigraphy in breast cancer: a nine-year follow-up. | the results of skeletal scintigraphy performed at presentation in 465 women with histologically confirmed carcinoma of the breast were correlated with tumour size, node status, clinical course and survival during a follow-up of at least 2 years and up to 9 years. skeletal metastases were eventually confirmed in 17.6% of the population under study, but were identified at presentation by scintigraphy in only half of these. the incidence of significant scintigraphic abnormalities ranged from 1.5% i ... | 1985 | 4064511 |
| protein utilization in growth: effect of calorie deficiency on serum growth hormone, somatomedins, total thyroxine (t4) and triiodothyronine, free t4 index, and total corticosterone. | we have studied the effect of a calorie-restricted diet on the growth of young rats and on serum levels of gh, somatomedins (insulin-like growth factors i and ii), total t4 and t3, free t4 index, and total corticosterone. experimental rats consumed the same quantities of protein and carbohydrate as control animals, but less fat, so that their calorie intake was approximately 76% that of controls. the mean (+/- sem) gh level in the experimental group (78 +/- 21 ng/ml) was not significantly differ ... | 1985 | 4065034 |
| subcellular localization of thyroxine 5'-deiodinase activity in bovine anterior pituitary. | bovine anterior pituitary glands were fractionated by differential centrifugation. t4 5'-monodeiodination to t3 was found predominantly in microsomal fractions (m2; 105,000 . g pellet) enriched in glucose-6-phosphatase and 5'-nucleotidase activities. t4 5'-deiodinase activity in m2 fraction was 85.2 fmol t3/min x mg protein and represented an 8.5-fold enrichment over homogenate specific activity (10.6 fmol t3/min . mg protein). further subcellular localization of the t4 5'-deiodinase was effecte ... | 1985 | 4065044 |
| effect of sex and age on serum aldosterone and thyroid hormones in the laboratory rat. | serum levels of aldosterone, tri-iodo thyronine (t3) and thyroxine (t4) were measured in male and female rats aged 3 months, 12 months, and 18 months. female rats were found to have higher aldosterone and t3 levels, and lower t4 level than the male. no age-related change was observed in serum aldosterone in either sex. in contrast, serum t4 were found to decrease with age in both sexes while serum t3 showed an age-associated diminution in the male only. serum testosterone was also measured in th ... | 1985 | 4065813 |
| surgery of toxic goiter: indications and long-term results. | treatment of hyperthyroidism is still debated, surgery in particular is conceived as the last step of a multidisciplinary approach. 130 patients were reviewed in a follow-up based on a double cell at fixed dates, after subtotal thyroidectomy for multinodular and diffuse toxic goiter. clinical and laboratory tests (t3, t4, tsh) showed a rate of 9.1% of recurrent toxicity and 20.7% of hypothyroidism. these data confirm that surgery offers satisfactory results in the management of hyperthyroidism i ... | 1985 | 4066273 |
| value of computed tomography in staging the primary lesion (t-staging) of nasopharyngeal carcinoma (npc): an analysis of 54 patients with special reference to the parapharyngeal space. | ct scans of the nasopharynx and the base of skull were performed in 54 patients with histologically proven npc. the ct findings are compared to those obtained by routine clinical examination. in this series, involvement of the parapharyngeal spaces was found by ct scan in 61% (33/54) of patients, which is impossible to assess by clinical means. intracranial invasion was demonstrated by ct scan with intravenous contrast enhancement in five patients. ct is more sensitive in showing the erosion of ... | 1985 | 4066445 |
| work intolerance in a horse with thyroid carcinoma. | a thyroid carcinoma was diagnosed in a 14-year-old competitive trail horse with a 3-month history of work intolerance. abnormal findings included low base-line triiodothyronine (t3) and thyroxine (t4) values, a large thyroid gland and decreased work tolerance. nuclear medicine scanning revealed displacement of the right thyroid gland by a mass. needle biopsy of the mass revealed neoplastic changes compatible with thyroid carcinoma. after removing the tumor surgically, t3 and t4 values returned t ... | 1985 | 4066461 |
| plasma thyroid hormones, growth and carcass measurements of genetically obese and lean pigs as influenced by thyroprotein supplementation. | a 2 x 2 factorial arrangement with two genotypes of pigs (genetically obese and lean) and two dietary treatments (basal, a 16% protein corn-soybean meal standard grower diet, and basal +220 ppm thyroprotein as iodinated casein) was used. the 28 gilts were housed individually and fed ad libitum from 121 d of age until slaughtered at 99 kg body weight. compared with lean pigs, genetically obese pigs had significantly lower average daily gain and gain/feed, greater backfat thickness, smaller loin e ... | 1985 | 4066527 |
| the prognostic value of thyroid function tests in predominantly non-alcoholic cirrhotic patients: a prospective investigation. | the prognostic value of thyroid function parameters (t3, t4, rt3 and the rt3:t3 ratio) and common liver tests (serum bilirubin, albumin and prothrombin activity) was investigated on hospital admission in 100 consecutive patients with predominantly non-alcoholic liver cirrhosis. twenty-nine out of 100 patients had a well compensated cirrhosis and their mean values of thyroid tests were similar to those of 40 healthy controls. a low t3 syndrome was found in the remaining 71 decompensated patients. ... | 1985 | 4067204 |
| thyroxine concentrations and secretion rates in relation to pregnancy, lactation and energy balance in goats. | plasma thyroxine (t4) concentrations were measured during pregnancy and lactation in goats on diets with different energy concentrations to study the role of t4 secretion in metabolic adaptation to pregnancy and lactation. thyroxine distribution space (the volume of fluid required to dissolve the total pool of circulating t4 at a concentration equal to that in the plasma) and secretion rates were determined by using 125i-labelled t4 at different stages of lactation and pregnancy. plasma concentr ... | 1985 | 4067495 |
| effects of the long-term (17-19 months) feeding of high-iodine eggs on lipid metabolism and thyroid function in rats. | the present paper describes the effects of long-term (17-19 months) feeding of high-iodine eggs on lipid metabolism and thyroid function of rats, and also the effects of inorganic iodine on lipid metabolism. rats were meal-fed on a diet containing 1% (w/w) of ordinary egg powder (oe diet as control: 35 micrograms i/100 g) or high-iodine egg powder (ie diet: 392 micrograms i/100 g). after the 19-month dietary treatment, rats fed on the ie diet, compared with the controls, showed a higher tissue l ... | 1985 | 4067667 |
| high threshold aortic baroreceptor afferents in the sympathetic nerve. | in anaesthetized cats, 40 sympathetic sensory units in the bracheocephalic artery (30 units) and the descending aorta (10 units) were recorded by means of single-unit preparation. direct evidence is available for the mechanosensitive nature of the receptors in the sympathetic afferents at the level of t3 and t4. two distinct types of receptors were found (type i and type ii). type i receptors, which were fast adapting, gave a spike discharge at each systolic height of pressure (70-110 mmhg). how ... | 1985 | 4068365 |
| [adaptive reactions of the thyroid system in patients with ischemic heart disease to graded physical exertion]. | data reflecting thyroid response to rationed exercise (bicycle ergometry) in coronary patients are presented with respect to physical stress tolerance and clinical form of coronary disease. the results were compared with those obtained in healthy untrained male subjects. exercise was carried on until submaximum capacity was reached, or clinical and/or electrocardiographic signs of coronary insufficiency appeared. radioimmune assays of blood thyrotropin and total triiodothyronine (t3) and thyroxi ... | 1985 | 4068456 |
| [changes in t4-deiodination in decompensated diabetes mellitus. the low-t3 syndrome]. | 1985 | 4068808 | |
| effects of thoracic spinal cord transection on colonic motor activity in rats. | the resting colonic motor activity before and consecutively after spinal cord transection was recorded in male sprague-dawley rats. recording probes were anchored surgically in the ascending and descending colon. pressure changes were recorded on a dynograph using a low compliance perfusion system. a motility index took into account the amplitude, duration and frequency of contractions. following a baseline recording animals were subjected either to spinal cord transection at t4 level or a sham ... | 1985 | 4069737 |
| effect of phosphorus deficiency on thyroid function and growth hormone in the white leghorn male. | leghorn males, 66 to 96 days of age, were fed a diet marginally deficient in phosphorus (.14% nonphytate). growth and feed intake were significantly reduced, but plasma calcium and phosphorus were unchanged. bone ash was significantly reduced compared to pair-fed controls but not ad libitum-fed controls. thyroid size increased and plasma growth hormone (gh) levels decreased with the deficiency, apart from any effect attributable to the lower food intake and weight gain. plasma 3,5,3'triiodothyro ... | 1985 | 4070136 |
| [should the assay of serum free thyroxine and triiodothyronine replace the other methods of evaluating thyroid function?]. | total t4, total t3, free t4 and free t3 were measured at the same time in 633 subjects. these subjects were classified according to the clinic state and the hormonal results in 426 euthyroid, 145 hyperthyroid and 62 hypothyroid cases. the results permitted to define the sensitivity, specificity and predictive value of the different tests. when each measure was considered alone, free t4 was the most useful test for all the hormonal states. in association, ft4 + ft3 is more useful than t3t + t4t f ... | 1985 | 4070850 |
| serum free thyroxine in patients with t3-toxicosis. | the serum free thyroxine concentration was measured by direct radioimmunoassay in 38 untreated t3-thyrotoxic patients with elevated serum total and free triiodothyronine, normal serum thyroxine and free thyroxine index, no tsh response to trh, and with clinical evidence of hyperthyroidism. an elevation of circulating free thyroxine values was observed in 58% of the patients, whereas total serum thyroxine concentration was within the normal range. it is suggested, therefore, that t3-thyrotoxicosi ... | 1985 | 4072576 |
| plasma free and total iodothyronine levels in hypophysectomized and intact lamb foetuses during the last third of gestation. | the changes in plasma levels of thyroxine (t4), free thyroxine (free t4), triiodothyronine (t3), free triiodothyronine (free t3), and reverse triiodothyronine (rt3) were observed in intact or hypophysectomized lamb foetuses during the last third of gestation. hypophysectomy was performed at two stages: 100 and 120 days of gestation. cord blood was collected after caesarean section. in intact foetuses, t4 and free t4 levels increased significantly between day 100 and 120 of gestation, but decreas ... | 1985 | 4072578 |
| large-screen image intensifier photofluorography compared with full-size screen-film technique in chest radiography. | large-screen image intensifier photofluorography revealed a radiation dose and exposure time of about one third of those of a medium speed rare-earth screen/film (trimax t4/xd) combination for full-size chest radiography. the resolving power of the former technique is somewhat poorer and there is a moderate electron-òptical distortion in the peripheral field. in clinical chest radiography photospot films showed excellent demonstration of the central areas of the image but slight deterioration in ... | 1985 | 4072746 |
| immunocompetent cells in bronchoalveolar lavage reflect the cell populations in transbronchial biopsies in pulmonary sarcoidosis. | the purpose of this study was to examine the relationship between the inflammatory cells seen in transbronchial lung biopsy samples (tbb) and the bronchoalveolar lavage fluid (bal) taken from patients with pulmonary sarcoidosis. monoclonal antibodies and histochemical methods were used to identify mononuclear inflammatory cells in cryostat tissue sections and to compare these with cell populations in bal-derived cytospin preparations. the subsets of lymphocytes identified in bal accurately refle ... | 1985 | 4073671 |
| expansion of a minor subpopulation of peripheral blood lymphocytes (t8+/leu 7+) in patients with haemophilia. | immunological analysis of peripheral blood mononuclear cells (pbm) was performed in 20 patients with haemophilia a or b. one of the patients had never received clotting factor substitution in his life. six different sources of lyophilized clotting factor were used for the other patients, but every given patient received factor from one source, exclusively. none of the patients exhibited lymphadenopathy and only one suffered from local bacterial infection. mononuclear cell counts were within the ... | 1985 | 4075588 |
| lymphocytopenia in donors undergoing regular platelet apheresis with cell separators. | the effect of regular platelet apheresis on lymphocyte count was investigated in 142 platelet donors who donated up to 113 times on haemonetics model 30 and fenwal model cs-3000 cell separators. lymphocytopenia (lymphocyte count less than 0.9 x 10(9)/l) was found in 21 out of 113 (18.6%) donors who donated solely on the haemonetics model 30 compared with 2 out of 100 (2%) whole blood donors and none of 100 plasmapheresis donors (p less than 0.002). lymphocyte count was inversely related to the t ... | 1985 | 4075737 |
| ria examinations of csf hormones as a method of demonstrating leakage through the blood-brain and brain-csf barriers. | radioimmunoassay determinations of the levels of total t3, total t4, tsh, and prolactin in the csf were performed on samples taken from 36 healthy individuals. the obtained reference values are the first of their kind. it is considered that ria determinations of csf hormone levels may provide a sensitive method for demonstrating pathological leakage through the blood-brain and brain-csf barriers. | 1985 | 4076241 |
| [investigations on the mechanism(s) of the production of anti-thyroid hormone antibodies 4: the effect of adjuvant on the immune response to human thyroglobulin]. | forty-five female ddyk mice were divided into three groups and immunized with different preparations of human thyroglobulin (htg). group 1 mice were immunized subcutaneously in the back with htg emulsified with fca. group 2 mice were immunized subcutaneously in the back with htg dissolved in pbs. group 3 mice were immunized with htg dissolved in pbs and fca separately in the right (htg) and left (fca) of the back. after the fourth immunization (45 days after the first immunization), antisera as ... | 1985 | 4076472 |
| effects of 17 beta-estradiol and methyl testosterone on the activity of the thyroid gland in rainbow trout, salmo gairdneri richardson. | methyl testosterone (mt) and 17 beta-estradiol (e2), suspended either in sesame oil (and injected on alternate days) or in warm hydrogenated coconut oil (and injected once in the form of an "implant"), were administered intraperitoneally to nonvitellogenic rainbow trout (salmo gairdneri richardson). when given as sesame oil injections e2 significantly reduced plasma triiodo-l-thyronine (t3) levels and thyroid epithelial cell height (teh), but had no apparent effect on plasma l-thyroxine (t4) lev ... | 1985 | 4076757 |
| potential of brown adipose tissue type ii thyroxine 5'-deiodinase as a local and systemic source of triiodothyronine in rats. | previous reports suggest that a type ii iodothyronine 5'-deiodinase may become the main enzymatic pathway for extrathyroidal triiodothyronine (t3) generation when the enzyme levels are sufficiently elevated and/or liver and kidney type i 5'-deiodinase activity is depressed. the present studies assessed the potential of brown adipose tissue (bat) type ii 5'-deiodinase to generate t3 for the plasma pool. bat 5'-deiodination (bat 5'd) was stimulated by either short- (4 h) or long-term (7 wk) cold e ... | 1985 | 4077981 |
| studies on experimental growth retardation in sheep. the effects of a small placenta in restricting transport to and growth of the fetus. | fetal and placental growth rate in sheep has been manipulated by removal of endometrial caruncles prior to conception. this produced two groups of fetuses, one in which prenatal growth rate was similar to normal and a second group in which the fetuses were about half of the normal size. the mortality in the latter group was high, particularly after catheterisation, and there was evidence of early intra-uterine death and fetal reabsorption. prior to 125 days the relationship between fetal and pla ... | 1985 | 4078258 |
| the fate of larval chondrocytes during the metamorphosis of the epibranchial in the salamander, eurycea bislineata. | the metamorphosis of the epibranchial cartilage, a skeletal component of the hyobranchial apparatus, in the salamander eurycea bislineata entails a combination of the reabsorption of a larval cartilaginous element with the simultaneous genesis of an adult cartilage in the same place. in this study we focus on the fate of the larval chondrocytes. two hypotheses are considered: one, larval cells simply die off during metamorphosis, or, alternatively, they dedifferentiate and participate in the for ... | 1985 | 4078541 |
| influences of feeding of high-iodine eggs on hypo- and hyperthyroid rats. | the effects of the feeding of high-iodine eggs to rats with an abnormal thyroid status were investigated. rats were fed for one week on a commercial diet supplemented with propylthiouracil (ptu) (10 mg/100 g diet) or thyroxine-na (240 micrograms/100 g diet) respectively, to induce hypo- or hyperthyroidism, and then further fed for 4 weeks on the respective drug-supplemented diets, containing 1% (w/w) of either ordinary or high-iodine egg powder. control (euthyroid) rats were maintained on the co ... | 1985 | 4078646 |
| [treatment of laryngeal cancer]. | from 1958 to 1984, 2000 patients with cancer of the larynx were treated in our clinic. irradiation therapy of full dose was the treatment of first choice for t1 cancers. partial laryngectomy was indicated for t2 cancers. for t3 and t4 cancers, total laryngectomy followed by the voice therapy of esophageal speech was performed. 10-year relative survival rate in total 2000 cases of laryngeal cancer was 74%. | 1985 | 4079046 |
| t4 rna ligase catalyzed synthesis of base analogue-containing oligodeoxyribonucleotides and a characterization of their thermal stabilities. | self-complementary oligodeoxyribonucleotides containing the base analogues 2-aminopurine, 2,6-diaminopurine, n6-methyladenine, uracil, and 5-bromouracil were synthesized by a general method that allows incorporation of the analogues at specific positions. the method uses chemically synthesized partial sequences but circumvents the need for protected base analogues by incorporating their unprotected 3',5'-bisphosphate derivatives enzymatically. t4 rna ligase was used to add the analogues to the o ... | 1985 | 4080551 |
| tumorectomy plus radiotherapy in the management of breast cancer. | from 1974 to 1982 a total of 58 patients with locoregional breast cancer, judged not suitable for demolitive surgery because of old age, bad general conditions or other reasons, were treated with simple tumorectomy followed by radiotherapy. the median age of the patients was 71 years. two patients had synchronous bilateral breast cancer, both treated with the same conservative approach. thirty-three tumors were classified as t1, 24 as t2, 1 as t3, and 2 as t4 of a small size. the median size of ... | 1985 | 4082289 |
| a controlled study on the effect of epidural analgesia with local anaesthetics and morphine on morbidity after abdominal surgery. | a hundred patients scheduled for elective abdominal surgery were randomized to either general anaesthesia (low-dose fentanyl) and systemic morphine for postoperative pain or combined general anaesthesia and epidural analgesia with etidocaine 1.5% intraoperatively (t4-s5) and bupivacaine 0.5% 5 ml/4 h for 24 h and morphine 4 mg/12 h for 72 h. postoperative pain was better controlled by the epidural regimen (p less than 0.0001). we found no significant reduction in postoperative mortality (6% to 2 ... | 1985 | 4082879 |
| circulatory changes during high thoracic epidural anaesthesia--influence of sympathetic block and of systemic effect of the local anaesthetic. | circulatory changes during high thoracic epidural anaesthesia (tea) were studied in nine healthy volunteers by means of echocardiography and systolic time intervals. the subjects also underwent a physical work test with bicycle ergometry. to evaluate the systemic effect of the local anaesthetic (bupivacaine), the same subjects were investigated 3 weeks later when a corresponding dose of the local anaesthetic was injected intramuscularly instead of epidurally. on the first occasion, after baselin ... | 1985 | 4082882 |
| serum concentrations of thyroxine and 3,5,3'-triiodothyronine before and after intravenous or intramuscular thyrotropin administration in dogs. | response to thyrotropin (tsh) was evaluated in 2 groups of mixed-breed dogs. thyrotropin (5 iu) was administered iv to dogs in group 1 (n = 15) and im to dogs in group 2 (n = 15). venous blood samples were collected immediately before administration of tsh and at 2-hour intervals for 12 hours thereafter. in group 1, the maximum mean concentration (+/- sd) of thyroxine (t4; 7.76 +/- 2.60 micrograms/dl) and 3,5,3'-triiodothyroxine (t3; 1.56 +/- 0.51 ng/ml) was attained at postinjection hours (pih) ... | 1985 | 4083599 |
| determination of the molecular mass of bacterial genomic dna and plasmid copy number by high-pressure liquid chromatography. | relatively rapid methods for the determination of relative genome molecular mass (mr) and the estimation of plasmid copy number have been developed. these methods are based on the ability of the bio-rad high-pressure liquid chromatography hydroxylapatite column to separate and quantify single-stranded dna, double-stranded dna, and plasmid dna. genome mr values were calculated from reassociation kinetics of single-stranded dna as measured with the hydroxylapatite column. bacteriophage t4 dna was ... | 1985 | 4083871 |
| a sheep preparation for studying interactions between blood flow and drug disposition. iv: the effects of general and spinal anaesthesia on blood flow and cefoxitin disposition. | control measurements of blood flow through and cefoxitin extraction ratios across heart and lungs, liver, kidneys and gut were made under steady-state conditions in awake unrestrained sheep. the studies then were repeated with the same animals anaesthetized with 1.5% halothane or whilst undergoing high thoracic (to approximately t4) subarachnoid blockade with amethocaine. in the control-drug studies, it was shown that cefoxitin was cleared by the kidneys and that the cefoxitin infusion produced ... | 1985 | 4084430 |
| right- and left-handed (z) helical conformations of the hairpin d(c-g)5t4(c-g)5 monomer and dimer. | the partial self-complementary 24-mer oligodeoxynucleotide d(c-g)5t4(c-g)5 forms a hairpin which can be enzymatically dimerized to a dumbbell structure. the blunt-ended nature of the hairpin is indicated by its ability to inhibit the t4 dna ligase catalyzed joining of phi x174 haeiii fragments. the hairpin monomer and dimer (dumbbell) undergo a reversible b to z transition as shown by ultraviolet, circular dichroism, and 31p nmr spectroscopy. the z form of the hairpin monomer and dimer is suppor ... | 1985 | 4084487 |
| first-line intravenous cisplatin for deeply invasive bladder cancer: update on 70 cases. | seventy patients with t2-t4 nx mo bladder cancer were treated with intravenous cisplatin (100 mg/m2 q 3-weekly) followed by radiotherapy and/or cystectomy. objective responses to cisplatin were seen in 57%. for the first group of 50 patients (treated between august 1981 and november 1983), the actuarial survival rate at 2 years was 64%, with a median survival of 20+ months: 81% of deaths occurred within 18 months of entry. most relapses occurred in the bladder/pelvis. a randomised, controlled st ... | 1985 | 4084727 |
| permanent defects in rat peripheral auditory function following perinatal hypothyroidism: determination of a critical period. | rats were treated with propylthiouracil (ptu) for 10-day periods beginning at different ages. daily injections of l-thyroxine (t4) were administered concurrently with ptu to a group of rats which served as one control group. peripheral auditory function was evaluated by the brainstem response audiometry (bsra) technique performed at 12, 16, 25 and 120 days of age. ptu treatment significantly increased wave i latency (cochlear nerve compound action potential) in adult rats when administered from ... | 1985 | 4084772 |
| prenatal exposure of the fetal rat to excessive l-thyroxine or 3,5-dimethyl-3'-isopropyl-thyronine produces persistent changes in the thyroid control system. | studies were conducted to determine if brief exposure, in utero, to high levels of t4 or to the synthetic thyromimetic agent 3,5-dimethyl-3'-isopropyl-l-thyronine (dimit) can produce permanent disruption of the thyroid control system in a manner analogous to the changes in the "set point" reported to occur due to neonatal t4 exposure in the "neo-t4 syndrome". if such a change were to occur, it could explain the persistent thyroid disturbances seen in the progeny of hypothyroid mother rats. these ... | 1985 | 4085974 |
| study of endocrine function in myotonic dystrophy. | endocrine function was studied in 12 patients, 7 men and 5 women, with myotonic dystrophy (md). growth hormone (gh) was within normal limits in all the patients and there was no response to arginine stimulation. prolactin (prl) was above normal in only 2 cases (one man and one woman) and the response to trh was below normal in 2 patients and slightly above in one. the gnrh test yielded a reduced lh response in 4 of the 7 men and none at all in the 4 women in whom it was done. the fsh response wa ... | 1985 | 4086265 |
| [posterior hernia of a calcified disk in children. apropos of 2 cases]. | posterior herniation of a calcified disk was detected in two children. a 10-year-old boy presented with cervicobrachial neuralgia at the c7 level secondary to herniation of a calcified c6-c7 disk treated by surgery. a 13-year-old boy was seen with a post-traumatic painful stiffness in the thoracic region posteriorly, without neurologic complication, secondary to a herniated calcified t4-t5 disk. surgery was not performed and the course was favorable with regression of clinical signs and spontane ... | 1985 | 4087235 |