Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| helicobacter pylori treatment: still a work in progress. | helicobacter pylori is a common worldwide bacterium, possessing adaptability that has created difficulty achieving eradication. while the standard treatment was thought to be triple therapy with a proton pump inhibitor, amoxicillin, and clarithromycin, growing rates of treatment failure and antibiotic resistance have stimulated research into novel regimens. quadruple therapy with bismuth has been compared for both first- and second-line treatments, but eradication still has not reached expected ... | 2016 | 26490697 |
| proton pump inhibitors and risk of periampullary cancers--a nested case-control study. | considerable attention has been focused on long-term use of proton pump inhibitor (ppi) medications in relation to increased risk of cancer via stimulation of dna-damaged cells. the aim of this study is to examine the dose-dependent effect of ppi on periampullary cancers in a national population-based cohort. a nested case-control analysis was constructed based on taiwan's national health insurance research database and the taiwan cancer registry between the years 2000 and 2010. cases involving ... | 2016 | 26488896 |
| atrophic gastritis and enlarged gastric folds diagnosed by double-contrast upper gastrointestinal barium x-ray radiography are useful to predict future gastric cancer development based on the 3-year prospective observation. | double-contrast upper gastrointestinal barium x-ray radiography (ugi-xr) is the standard gastric cancer screening method in japan. atrophic gastritis and enlarged gastric folds are considered the two major features of helicobacter pylori-induced chronic gastritis, but the clinical meaning of evaluating them by ugi-xr has not been elucidated. | 2016 | 26486508 |
| pepsinogen-ii 100 bp ins/del gene polymorphism and its elevated circulating levels are associated with gastric cancer, particularly with helicobacter pylori infection and intestinal metaplasia. | polymorphism in the gene of pepsinogen-ii (pg-ii) and its serum level are effective biomarkers for terminal differentiation of gastric mucosa into gastritis, intestinal metaplasia (im), and gastric cancer (gc) in relationship to helicobacter pylori infection. | 2016 | 26486507 |
| the male predominance in esophageal adenocarcinoma. | the incidence of esophageal adenocarcinoma (eac) has increased rapidly during the past 4 decades in many western populations, including north america and europe. the established etiological factors for eac include gastroesophageal reflux and obesity, helicobacter pylori infection, tobacco smoking, and consumption of fruit and vegetables. there is a marked male predominance of eac with a male-to-female ratio in incidence of up to 9:1. this review evaluates the available literature on the reasons ... | 2016 | 26484704 |
| immunomodulatory effects of psyllium extract on helicobacter pylori interaction with gastric epithelial cells. | natural plant product psyllium has anti-inflammatory activity that can modulate the function of cytokines. we determined the effect of psyllium husk extract on interleukin (il)-8 and nf-κb secretion by gastric epithelial cells in response to helicobacter pylori human gastric adenocarcinoma cell line (ags) cells were pretreated with psyllium extract in different concentrations before h pylori infection. cell culture supernatant was analyzed for il-8 and nf-κb by elisa. rna from cells was used for ... | 2016 | 26474925 |
| how effective is the quadruple concomitant helicobacter pylori eradication therapy for obese patients undergoing gastric bypass surgery? | our aim was to assess, in obese patients undergoing roux-en y gastric bypass surgery, the quadruple concomitant hp eradication rates at first line treatment as proposed by the maastricht iv consensus in areas of high clarithromycin resistance rates-proton pump inhibitor bid, clarithromycin 500 mg bid, amoxicillin 1000 mg bid, and metronidazole 500 mg bid. this is a single center prospective study over a 3-year period. endoscopy and hp assessment (by histology or c13 urea breath) were performed a ... | 2016 | 26467690 |
| helicobacter pylori resistance to six antibiotics by two breakpoint systems and resistance evolution in bulgaria. | helicobacter pylori resistance to antibiotics is the main cause for eradication failures. | 2016 | 26465202 |
| eradication rates of helicobacter pylori in korea over the past 10 years and correlation of the amount of antibiotics use: nationwide survey. | the efficacy of proton-pump inhibitor-amoxicillin-clarithromycin therapy for h. pylori eradication has decreased over time. | 2016 | 26470999 |
| helicobacter pylori infection and gastroesophageal reflux in children. | some studies suggest that helicobacter pylori (h. pylori) infection would be a protective factor for the gastroesophageal reflux. the aim of this study was to explore this fact. a group of 72 children, admitted in a pediatric gastroenterology regional center in northeast romania, diagnosed with gastroesophageal reflux by 24-hour continuous esophageal ph monitoring (results were interpreted using the boix-ochoa score), underwent upper endoscopy with gastric biopsy to detect the presence of h. pyl ... | 2016 | 26455913 |
| precancerous histopathologic lesions of upper gastrointestinal tract among dyspeptic patients upon endoscopic evaluations. | gastric cancer is one of the most important causes of morbidity and mortality worldwide which is influenced by different risk factors. this study aimed to investigate the effects of various factors associated with precancerous lesions among dyspeptic patients. | 2016 | 26454647 |
| levofloxacin susceptibility testing against helicobacter pylori: evaluation of a modified disk diffusion method compared to e test. | we compared levofloxacin (1 μg/disk) disk diffusion method to e test against 212 helicobacter pylori strains. using diameter breakpoints for susceptibility (≥15 mm) and resistance (≤9 mm), very major error, major error rate, and categoric agreement were 0.0%, 0.6%, and 93.9%, respectively. the method may be useful in low-resource laboratories. | 2016 | 26454324 |
| a rare case of sarcina ventriculi of the stomach in an asymptomatic patient. | sarcina ventriculi is a gram-positive coccus that grows in a tetrad arrangement in the stomach. in the past 35 years, less than 20 cases have been reported in the literature, and it has been associated with life-threatening complications such as emphysematous gastritis and perforation. treatment of s ventriculi generally consists of proton pump inhibitors with or without adjuvant antibiotic therapy. we report the first ever case of s ventriculi, including the morphological and immunohistochemica ... | 2016 | 26453674 |
| helicobacter pylori outer membrane protein q allele distribution is associated with distinct pathologies in pakistan. | helicobacter pylori (h. pylori) strains expressing outer membrane protein q (hopq) promote adherence to the gastric epithelial cell. we characterized hopq alleles in relation to h. pylori-related disease, histology and virulence markers. gastric biopsies were obtained at esophagogastroduodenoscopy from patients with upper gastrointestinal symptoms. h. pylori culture, histology and polymerase chain reaction (pcr) for hopq types, caga, caga-promoter and vaca alleles were performed. dna extracted w ... | 2016 | 26516025 |
| decrease of serum total ghrelin in extensive atrophic gastritis: comparison with pepsinogens in histological reference. | ghrelin is mainly secreted by the gastric oxyntic mucosa and its production is impaired in chronic atrophic gastritis. this study aimed at evaluating how serum total ghrelin correlates with the extent of atrophy, and to compare its performance as a serologic marker with that of pepsinogen (pg). | 2016 | 26513345 |
| clarithromycin synergistically enhances thalidomide cytotoxicity in myeloma cells. | clarithromycin (cam) is a macrolide antibiotic that is widely used in the treatment of respiratory tract infections, sexually transmitted diseases and infections caused by the helicobacter pylori and mycobacterium avium complex. recent studies showed that cam was highly effective against multiple myeloma (mm) when used in combination with immunomodulatory drugs and dexamethasone. however, the related mechanism is still unknown. as 3 immunomodulatory agents are all effective in the respective reg ... | 2016 | 26505646 |
| in vitro antimicrobial susceptibility of helicobacter pylori to nine antibiotics currently used in central italy. | helicobacter pylori expresses an increased resistance in respect to antimicrobials currently used in therapy. the aim of this study was to evaluate the antimicrobial profiles of h. pylori isolates to nine conventional antibiotics used in a central region (abruzzo) of italy. | 2016 | 26554617 |
| high-level primary clarithromycin resistance of helicobacter pylori in algiers, algeria: a prospective multicenter molecular study. | knowledge of local antibiotic resistance is crucial to adaptation for the choice of the optimal first-line treatment for helicobacter pylori infection. clarithromycin is a key component of the standard triple therapy largely used worldwide and, more particularly, in algeria. clarithromycin resistance is the main risk factor for treatment failure. the aim of this study was to evaluate, for the first time in algeria, the prevalence of the primary resistance of h. pylori to clarithromycin. we condu ... | 2016 | 26554340 |
| preoperative helicobacter pylori infection is associated with increased survival after resection of gastric adenocarcinoma. | limited data exist on the prognosis of preoperative helicobacter pylori (h. pylori) infection in gastric adenocarcinoma (gac). | 2016 | 26553442 |
| bone marrow involvement is rare in superficial gastric mucosa-associated lymphoid tissue lymphoma. | the initial staging work-up of gastric mucosa-associated lymphoid tissue (malt) lymphoma includes bone marrow examination. since gastric malt lymphoma is mostly detected in early stages with the national cancer screening programme in korea, bone marrow is rarely involved. | 2016 | 26548745 |
| atg16l1 t300a polymorphism is correlated with gastric cancer susceptibility. | gastric cancer is a major leading cause of cancer-related death in both sexes in europe. the role of autophagy process in carcinogenesis remains unclear and there is increasing evidence that helicobacter pylori is a key player in modulating autophagy in gastric carcinogenesis. the aim of this study was to assess the potential association of atg16l1 t300a polymorphism with susceptibility of gastric cancer, and further to analyze the expression profile of atg16l1 gene in paired tumoral and peritum ... | 2016 | 26547861 |
| lectin-conjugated clarithromycin and acetohydroxamic acid-loaded plga nanoparticles: a novel approach for effective treatment of h. pylori. | helicobacter pylori infection remains challenging as it mainly colonized beneath the deep gastric mucosa and adheres to epithelial cells of the stomach. concanavalin-a (con-a)-conjugated gastro-retentive poly (lactic-co-glycolic acid) (plga) nanoparticles of acetohydroxamic acid (aha) and clarithromycin (clr) were prepared and evaluated under in vitro conditions. solvent evaporation method was employed for preparation of nanoparticles and characterized for particle size distribution, surface mor ... | 2016 | 26566630 |
| multiple and mixed helicobacter pylori infections: comparison of two epidemiological situations in tunisia and france. | individuals can be infected by either a single or multiple strains of helicobacter pylori. multiple infection with genetically different isolates and particularly mixed infection with both antibiotic-susceptible and resistant isolates are difficult to detect and should impact the effectiveness of eradication treatment. it is largely assumed that multiple infections are more frequent in developing countries but an actual comparison developing/developed using a single methodology has never been re ... | 2016 | 26518911 |
| a comparison of five different treatment regimens as the first-line treatment of helicobacter pylori in turkey. | the h. pylori eradication success is low in countries with high antibiotic resistance to h. pylori. | 2016 | 26621567 |
| comment on "the relationship of recurrent aphthous stomatitis and helicobacter pylori, cytokine gene polymorphism and cobalamin". | 2016 | 26620964 | |
| helicobacter pylori screening: options and challenges. | helicobacter pylori gastritis is the most frequent infectious disease in the gastrointestinal tract. clinical sequelae of the infection including peptic ulcer disease, sporadic gastric cancer (gc) and primary b-cell gastric lymphoma (malt-lymphoma) may develop in up to 20% of the infected individuals. the h. pylori screen-and-treat strategy is addressed to members of communities with high gc incidence, and first-degree relatives of gc patients. for primary gc prevention, h. pylori screen-and-tre ... | 2016 | 26619972 |
| helicobacter pylori antigens, acetylsalicylic acid, ldl and 7-ketocholesterol - their potential role in destabilizing the gastric epithelial cell barrier. an in vitro model of kato iii cells. | colonization of gastric tissue in humans by h. pylori gram-negative bacteria initiates gastric and duodenal ulcers and even gastric cancers. infections promote inflammation and damage to gastric epithelium which might be followed by the impairment of its barrier function. the role of h. pylori components in these processes has not been specified. h. pylori cytotoxicity may potentially increase in the milieu of anti-inflammatory drugs including acetylsalicylic acid (asa). the lipid transport-asso ... | 2016 | 26619253 |
| clarithromycin resistance mutations in helicobacter pylori in association with virulence factors and antibiotic susceptibility of the strains. | antibiotic resistance is the major cause for helicobacter pylori eradication failure. h. pylori clarithromycin resistance mutations were evaluated in 84 (82 phenotypically clarithromycin resistant and 2 intermediately susceptible) strains by allele-specific pcr and 3'-mismatched pcr. many (57.1%) of these strains were metronidazole resistant. prevalence of caga(+), cage(+), vaca s1a, m1, i1, and i2 strains was 76.2%, 58.0%, 82.1%, 35.7%, 50.0%, and 50.0%, respectively. a2143g, a2142g, a2142c, an ... | 2016 | 26618567 |
| structural basis for substrate specificity of helicobacter pylori m17 aminopeptidase. | the m17 aminopeptidase from the carcinogenic gastric bacterium helicobacter pylori (hpm17ap) is an important housekeeping enzyme involved in catabolism of endogenous and exogenous peptides. it is implicated in h. pylori defence against the human innate immune response and in the mechanism of metronidazole resistance. bestatin inhibits hpm17ap and suppresses h. pylori growth. to address the structural basis of catalysis and inhibition of this enzyme, we have established its specificity towards th ... | 2016 | 26616008 |
| activation of nlrp3 inflammasome in human neutrophils by helicobacter pylori infection. | tlrs and nlrs participate in the immune system recognition of helicobacter pylori. however, little is known about the mechanisms leading to inflammasome activation by h. pylori and if nlrs in neutrophils are involved in the process. we studied how nod-like receptor family, pyrin domain-containing 3 (nlrp3) inflammasome components are involved in il-1β maturation in human neutrophils in response to the infection and if they are dependent on t4ss (type iv secretion system) and tlrs. human neutroph ... | 2016 | 26610398 |
| hp-normogram (normo-graham) for assessing the outcome of h. pylori therapy: effect of resistance, duration, and cyp2c19 genotype. | there have been hundreds of h. pylori eradication trials and yet doubt remains regarding the best regimen for any situation. with most regimens, treatment failure is the result of resistance to one component (e.g., clarithromycin). thus, if one knows the treatment success with two groups (all with susceptible and with all with resistant infections), one can construct a normogram that provides a reliable estimate of the outcome at any prevalence of resistance. the same data can be used to estimat ... | 2016 | 26612515 |
| efficacy of 10-day sitafloxacin-containing third-line rescue therapies for helicobacter pylori strains containing the gyra mutation. | sitafloxacin-containing helicobacter pylori eradication therapy is a promising third-line therapeutic approach, but there is no previous studies between gyra mutation status of h. pylori strains and the efficacy of 10-day sitafloxacin-containing regimens. here, we assessed the efficacy of 2 different 10-day sitafloxacin-containing rescue regimens. | 2016 | 26612407 |
| relevance of helicobacter pylori vaca 3'-end region polymorphism to gastric cancer. | helicobacter pylori vaca genotypes play an important role in the pathogenesis of severe gastrointestinal disease. | 2016 | 26612250 |
| the presence of phage orthologous genes in helicobacter pylori correlates with the presence of the virulence factors caga and vaca. | the bacterium helicobacter pylori is associated with ulcers and the development of gastric cancer. several genes, including cytotoxin-associated gene a (caga) and vacuolating cytotoxin a (vaca), are associated with increased gastric cancer risk. some strains of h. pylori also contain sequences related to bacteriophage phihp33; however, the significance of these phage-related sequences remains unknown. | 2016 | 26612095 |
| premature birth and large for gestational age are associated with risk of barrett's esophagus in adults. | birth characteristics, including weight and gestational age, may be associated with risk of barrett's esophagus (be), the only known precursor for esophageal adenocarcinoma; however, data are limited. | 2016 | 26611860 |
| α-lipoic acid inhibits expression of il-8 by suppressing activation of mapk, jak/stat, and nf-κb in h. pylori-infected gastric epithelial ags cells. | the epithelial cytokine response, associated with reactive oxygen species (ros), is important in helicobacter pylori (h. pylori)-induced inflammation. h. pylori induces the production of ros, which may be involved in the activation of mitogen-activated protein kinases (mapk), janus kinase/signal transducers and activators of transcription (jak/stat), and oxidant-sensitive transcription factor, nuclear factor kappa-light-chain-enhancer of activated b cells (nf-κb), and thus, expression of interle ... | 2016 | 26632410 |
| serologic evidence for fecal-oral transmission of helicobacter pylori. | helicobacter pylori infection is among the most prevalent infections in the world and a key cause of gastric diseases; however, its route of transmission remains unclear. this study aimed to assess the potential for fecal-oral transmission of h. pylori by leveraging its association with a disease with known etiology. utilizing serology data from the national health and nutrition examination survey (nhanes 1999; n = 6,347), the association between h. pylori and hepatitis a virus (hav), a sensitiv ... | 2016 | 26598563 |
| managing helicobacter pylori in college health, with special considerations for international students. | helicobacter pylori infection is the major cause of dyspepsia, peptic ulcer disease, and gastric cancer. this paper will make specific recommendations for a diagnostic and treatment strategy tailored to the international student population. | 2016 | 26595094 |
| review article: the prevalence of helicobacter pylori and the incidence of gastric cancer across europe. | there is little up-to-date review evidence on the prevalence of helicobacter pylori across europe. | 2016 | 26592801 |
| downregulated expression of e-cadherin and tp53 in patients with gastric diseases: the involvement of h. pylori infection and its virulence markers. | gastritis caused by infection with helicobacter pylori is characterized by chronic inflammation and damage in gastric tissue, which is a main risk factor for gastric cancer. associated with h. pylori, the tp53 gene tumor suppressor and the cell adhesion glycoprotein epithelial cadherin develop a relevant role in the integrity and carcinogenesis of the epithelium. we aimed to detection of h. pylori and its main virulence markers and measured the messenger rna (mrna) expression levels of e-cadheri ... | 2016 | 26585943 |
| alcohol intake and helicobacter pylori infection: a dose-response meta-analysis of observational studies. | background alcohol intake has been suggested to have an impact on the development of many chronic diseases. how alcohol intake may modulate risk of helicobacter pylori (h. pylori) infection, however, remains a subject open for investigation. a dose-response meta-analysis was performed of epidemiological studies to better quantify this relationship. materials and methods twelve observational articles were identified. the summary odds ratio (or) and confidence intervals (ci) were calculated for al ... | 2016 | 26585858 |
| effect of helicobacter pylori eradication on long-term survival after distal gastrectomy for gastric cancer. | negative helicobacter pylori status has been identified as a poor prognostic factor for survival in gastric cancer (gc) patients who underwent surgery. the aim of this study was to examine the effect of h. pylori eradication on long-term outcomes after distal gastrectomy for gc. | 2016 | 26582396 |
| effect of rumex aquaticus herba extract against helicobacter pylori-induced inflammation in gastric epithelial cells. | the purposes of this study were to examine the characteristics of helicobacter pylori and the effect of rumex aquaticus herba extract on the expression of cytokines in h. pylori-infected gastric epithelial cells. cultured human adenocarcinoma gastric cells (ags) were infected by h. pylori in rpmi 1640 media. cell growth was measured by trypan blue assay. western blot analysis was performed to investigate effect of extract containing quercetin-3-o-β-d-glucuronopyranoside (ecq) on the expression o ... | 2016 | 26580421 |
| abcg2 in peptic ulcer: gene expression and mutation analysis. | the aim of this study was to evaluate the participation of polymorphism at position c421a and mrna expression of the abcg2 gene in the development of peptic ulcers, which is a very common and severe disease. abcg2, encoded by the abcg2 gene, has been found inter alia in the gastrointestinal tract, where it plays a protective role eliminating xenobiotics from cells into the extracellular environment. the materials for the study were biopsies of gastric mucosa taken during a routine endoscopy. for ... | 2016 | 26578453 |
| prevention of infection-related cancers in the who western pacific region. | a considerable number of infectious agents have been classified as human carcinogens group 1 by the international agency for research on cancer. major infection-related cancers such as cancers of nasopharynx (53%), stomach (60%) and liver (63%) occur in the world health organization western pacific region. many infection-related cancers are preventable, particularly those associated with human papilloma virus, helicobacter pylori, human immunodeficiency virus-i, hepatitis b virus and hepatitis c ... | 2016 | 26563255 |
| new and unexpected biological functions for the src-homology 2 domain-containing phosphatase shp-2 in the gastrointestinal tract. | shp-2 is a tyrosine phosphatase expressed in most embryonic and adult tissues. shp-2 regulates many cellular functions including growth, differentiation, migration, and survival. genetic and biochemical evidence show that shp-2 is required for rat sarcoma viral oncogene/extracellular signal-regulated kinases mitogen-activated protein kinase pathway activation by most tyrosine kinase receptors, as well as by g-protein-coupled and cytokine receptors. in addition, shp-2 can regulate the janus kinas ... | 2016 | 28174704 |
| use of clia-waived point-of-care tests for infectious diseases in community pharmacies in the united states. | review of point-of-care (poc) testing in community pharmacies, availability and specifications of clia-waived infectious disease poc tests, and provide recommendations for future community pharmacy poc models in an effort to improve patient outcomes while reducing antibiotic resistance. pubmed and medscape were searched for the following keywords: infectious disease, community pharmacy, rapid diagnostic tests, rapid assay, and poc tests. all studies utilizing poc tests in community pharmacies fo ... | 2016 | 26560318 |
| safety of proton pump inhibitors and risk of gastric cancers: review of literature and pathophysiological mechanisms. | despite being an overall safe drug, several long-term adverse effects are associated with proton pump inhibitors (ppis). the link between ppi use and gastric neuroendocrine tumors (nets), gastric adenocarcinomas and barrett's esophagus progression gastric cancers has been investigated due to ppi-induced hypergastrinemia. | 2016 | 26560097 |
| risk of gastric cancer, gastrointestinal cancers and other cancers: a comparison of treatment with pantoprazole and other proton pump inhibitors. | proton pump inhibitors (ppis) have been shown to be carcinogenic in rodent studies. | 2016 | 26541643 |
| identification of novel scaffolds for potential anti-helicobacter pylori agents based on the crystal structure of h. pylori 3-deoxy-d-manno-octulosonate 8-phosphate synthase (hpkdo8ps). | the crystal structure of 3-deoxy-d-manno-octulosonate-8-phosphate synthase (kdo8ps) from helicobacter pylori (hpkdo8ps) was determined alone and within various complexes, revealing an extra helix (he) that is absent in the structures of kdo8ps from other organisms. in contrast to the metal coordination of the kdo8ps enzyme from aquifex aeolicus, hpkdo8ps is specifically coordinated with cd(2+) or zn(2+) ions, and isothermal titration calorimetry (itc) and differential scanning fluorimetry (dsf) ... | 2016 | 26649906 |
| screening for helicobacter pylori in idiopathic pulmonary fibrosis lung biopsies. | increasing evidence suggests a role of gastro-oesophageal reflux (ger) in idiopathic pulmonary fibrosis (ipf) pathogenesis. recently, an association between serum helicobacter pylori (hp) antibody positivity and more severe disease was described, but hp has not been directly analysed in lung tissue so far. | 2016 | 26645213 |
| helicobacter pylori vacuolating cytotoxin genotypes and preneoplastic lesions or gastric cancer risk: a meta-analysis. | disease progression to gastric cancer (gc) occurs in only a small proportion of helicobacter pylori (h. pylori) infected patients. the bacterium vacuolating cytotoxin a (vaca) gene polymorphisms may determine the clinical consequences. we examined the strength of this association in adult-infected populations and modeled the impact of mean age-standardized incidence rates (asrs) of gc as a hypothesized moderator variable. | 2016 | 26648346 |
| inhibition of helicobacter pylori and its associate urease by labdane diterpenoids isolated from andrographis paniculata. | the present study was carried out to evaluate anti-helicobacter pylori and its associated urease activity of labdane diterpenoids isolated from andrographis paniculata. a molecular docking analysis was performed by using arguslab 4.0.1 software. the results obtained indicate that compound a possesses strong inhibition to h. pylori, 28 ± 2.98 (minimum inhibitory concentration, 9 µg/ml), and its urease, 85.54 ± 2.62% (ic50 , 20.2 µg/ml). compounds b, c, and d also showed moderate inhibition to h. ... | 2016 | 26648323 |
| the homing receptor cd44 is involved in the progression of precancerous gastric lesions in patients infected with helicobacter pylori and in development of mucous metaplasia in mice. | infection with helicobacter pylori (h. pylori) leads to inflammatory events that can promote gastric cancer development. immune cells transition from the circulation into the infected mucosa through the interaction of their receptors and ligands in the endothelial compartment. cd44 expression is increased in advanced gastric lesions. however, the association of this molecule with the progression of these lesions over time has not been investigated. in addition, there is a lack of understanding o ... | 2016 | 26639196 |
| letter: promising results of helicobacter pylori eradication with vonoprazan-based triple therapy after failure of proton pump inhibitor-based triple therapy. | 2016 | 26638943 | |
| severe gastritis decreases success rate of helicobacter pylori eradication. | in several studies, different risk factors other than antibiotic resistance have been documented with helicobacter pylori eradication failure. we aimed in this study to investigate the relationship of gastric density of h. pylori, the occurrence/degree of gastric atrophy, and intestinal metaplasia (im) with success rate of h. pylori eradication. | 2016 | 26637331 |
| effect of timing of proton pump inhibitor administration on acid suppression. | esomeprazole has been reported to show a strong acid suppression following preprandial as compared to postprandial administration, though no known study has compared the acid suppressing effects of other proton pump inhibitors between those administrations. the aim of this study was to compare intragastric ph levels following pre- and postprandial administrations of rabeprazole and esomeprazole. | 2016 | 26637113 |
| adverse drug reactions due to drug-drug interactions with proton pump inhibitors: assessment of systematic reviews with amstar method. | many systematic reviews resulted in claims on drug-drug interactions (ddis) with proton pump inhibitors (ppis). such a large number begs for consensus on the clinical significance of findings. | 2016 | 26635063 |
| three unsuccessful treatments of helicobacter pylori infection by a highly virulent strain with quadruple antibiotic resistance. | we report a case of an adult patient undergoing three unsuccessful helicobacter pylori treatments, including proton pump inhibitor (ppi), bismuth subcitrate, metronidazole and tetracycline in 2012, ppi, amoxicillin and clarithromycin in 2013, and ppi, amoxicillin and rifampin in 2014. following the first treatment, the isolate was metronidazole and ciprofloxacin/levofloxacin resistant. after the second treatment, the isolate was resistant to metronidazole, ciprofloxacin/levofloxacin and rifampin ... | 2016 | 26634607 |
| human gastric cancer, helicobacter pylori and bracken carcinogens: a connecting hypothesis. | long term infection of helicobacter pylori (hp) virulent strains is a key factor in the genesis of human gastric cancer, and so are certain dietary proinflammatory and genotoxic compounds. carcinogenic bracken fern (pteridium spp.) is one of these. toxins from this plant are consumed as bracken culinary preparations, through milk and meat of bracken-exposed livestock, and drain waters from bracken swards. bracken toxin ptaquiloside (ptq), a suspected human carcinogen, elicits complex responses i ... | 2016 | 26632203 |
| an integrated microfluidic system for diagnosis of the resistance of helicobacter pylori to quinolone-based antibiotics. | helicobacter pylori (h. pylori) is a species of bacteria that can colonize the human stomach mucosa. it is closely associated with gastric diseases such as ulcer and inflammation. recently, some h. pylori strains were found to express resistance to a family of antibiotics known as quinolones due to single-point mutations. although traditional polymerase chain reaction (pcr) and molecular diagnostic-based approaches can be used to determine the presence and abundance of antibiotic-resistant h. py ... | 2016 | 26630283 |
| helicobacter pylori infection and children's growth: an overview. | helicobacter pylori infection is acquired in early childhood, yet its role in children's health is still not fully clear. in this narrative review, we focused on the association between h pylori infection and children's growth. | 2016 | 26628446 |
| one or two weeks of treatment with helicobacter pylori ''standard'' triple therapy in the year 2015? | 2016 | 26655127 | |
| helicobacter pylori-induced gastric mucosal tgf-α ectodomain shedding and egfr transactivation involves rac1/p38 mapk-dependent tace activation. | infection of gastric mucosa by h. pylori triggers a pattern of inflammatory responses characterized by the rise in proinflammatory cytokine production, up-regulation in mitogen-activated protein kinase (mapk) cascade, and the induction in epidermal growth factor receptor (egfr) activation. in this study, we report on the role of mapk/p38 and rac1 in the regulation of h. pylori lps-induced tgf-α ectodomain shedding and egfr transactivation. we show that stimulation of gastric mucosal cells with t ... | 2016 | 26658844 |
| vaca, caga, icea and oipa genotypes status and antimicrobial resistance properties of helicobacter pylori isolated from various types of ready to eat foods. | despite the high clinical standing of helicobacter pylori, its exact routes of transmission and origin have not been determined. based on the contentious hypothesis, foods play an important roles in the transmission of h. pylori to humans. the present study was carried out to investigate the vaca, caga, oipa and icea genotypes status of h. pylori isolated from the various types of ready to eat foods. | 2016 | 26792758 |
| bacterial overgrowth and diversification of microbiota in gastric cancer. | microbiota is potentially linked to the development of cancer. however, the features of microbiota in gastric cancer remain unclear. the aim of this study was to characterize the gastric microbiota in cancer. | 2016 | 26657453 |
| [stomach cancer: a descriptive study of 101 cases at the gastrointestinal endoscopy center at aristide le dantec university hospital]. | stomach cancer is a real public health problem in black africa. we report its epidemiological, endoscopic, and histological aspects, as observed in our gastrointestinal endoscopy center at aristide le dantec university hospital in dakar (senegal). | 2016 | 26680270 |
| effects of helicobacter pylori eradication on the development of metachronous gastric cancer after endoscopic treatment: analysis of molecular alterations by a randomised controlled trial. | whether helicobacter pylori eradication actually suppresses the development of metachronous gastric cancer (mgc) after endoscopic resection (er) remains controversial. the aims of this study were to clarify (1) the molecular markers related to carcinogenesis in intestinal metaplasia (im) by a cross-sectional study, and (2) the changes of those markers by an open-label, randomised controlled trial (rct) of h. pylori treatment. | 2016 | 26671747 |
| quantitative detection and genotyping of helicobacter pylori from stool using droplet digital pcr reveals variation in bacterial loads that correlates with caga virulence gene carriage. | epidemiologic studies of the carcinogenic stomach bacterium helicobacter pylori have been limited by the lack of noninvasive detection and genotyping methods. we developed a new stool-based method for detection, quantification, and partial genotyping of h. pylori using droplet digital pcr (ddpcr), which allows for increased sensitivity and absolute quantification by pcr partitioning. | 2016 | 26667241 |
| helicobacter pylori infection in children: nutritional status and associations with serum leptin, ghrelin, and igf-1 levels. | helicobacter pylori is associated with gastrointestinal diseases such as gastritis, peptic ulcers, malignancy and lymphoma, and extra-gastrointestinal conditions. h. pylori infection is negatively associated with children's growth. chronic inflammation of the stomach that results in the loss of appetite and, dysregulation of neuroendocrine hormones such as leptin, and ghrelin are the probable reasons of this negative association. the objective of this study is to determine the serum levels of le ... | 2016 | 26667121 |
| design, optimization, and evaluation of a novel metronidazole-loaded gastro-retentive ph-sensitive hydrogel. | floating ph-sensitive chitosan hydrogels containing metronidazole were developed for the eradication of helicobacter pylori from the stomach. hydrogels were prepared by crosslinking medium or high molecular weight chitosan in lyophilized solutions containing metronidazole using either citrate or tripolyphosphate (tpp) salts at 1% or 2% concentration. a 2(3) factorial design was developed to study the influence of formulation parameters on the physical characteristics of the prepared hydrogels. t ... | 2016 | 26689404 |
| gastroprotective effects of thymol on acute and chronic ulcers in rats: the role of prostaglandins, atp-sensitive k(+) channels, and gastric mucus secretion. | thymol, a monoterpene phenol derivative of cymene, is found in abundance in the essential oils of thymus, origanum, and lippia species. the present study investigated the gastroprotective actions of thymol (10, 30, and 100 mg/kg, p.o.) in the acute (ethanol- and nonsteroidal anti-inflammatory drug-induced ulcers) and chronic (acetic acid-induced ulcers) ulcer models in rats. some of the mechanisms underlying to the gastroprotective effect of thymol were investigated in the ethanol-induced ulcer ... | 2016 | 26689173 |
| binary and tertiary mixtures of satureja hortensis and origanum vulgare essential oils as potent antimicrobial agents against helicobacter pylori. | essential oils possess strong antimicrobial activity, even against multiresistant helicobacter pylori. available therapies against h. pylori infection have multiple disadvantages, indicating a great need for a development of new therapeutics. the purpose of this study was to develop a potent natural product based anti-h. pylori formulation. first, anti-h. pylori activity of nine essential oils was determined, after which the most active oils were mixed in various ratios for further testing. satu ... | 2016 | 26686190 |
| diagnosis of helicobacter pylori infection is associated with lower prevalence and subsequent incidence of crohn's disease. | helicobacter pylori infection may protect against some chronic inflammatory diseases. this study examined h. pylori infection and its association with the prevalence of the gastrointestinal diseases crohn's disease [cd], ulcerative colitis [uc], and coeliac disease [ced]. incident cases in a follow-up period after h. pylori testing were recorded to investigate if protective effects of h. pylori persisted after probable eradication. | 2016 | 26674958 |
| systematic review with meta-analysis: 10- or 14-day sequential therapy vs. 14-day triple therapy in the first line treatment of helicobacter pylori infection. | whether 10-day or 14-day sequential therapy is superior to 14-day triple therapy in the first-line treatment of helicobacter pylori remains controversial. | 2016 | 26669729 |
| comparison of helicobacter pylori urease inhibition by rhizoma coptidis, cortex phellodendri and berberine: mechanisms of interaction with the sulfhydryl group. | rhizoma coptidis, cortex phellodendri, and berberine were reported to inhibit helicobacter pylori. however, the underlying mechanism remained elusive. urease plays a vital role in h. pylori colonization and virulence. in this work, aqueous extracts of rhizoma coptidis, cortex phellodendri of different origins, and purified berberine were investigated against h. pylori urease and jack bean urease to elucidate the inhibitory capacity, kinetics, and mechanism. results showed that berberine was the ... | 2016 | 26669678 |
| helicobacter pylori with high thioredoxin-1 expression promotes stomach carcinogenesis in mongolian gerbils. | previous studies by this group have shown that helicobacter pylori with high thioredoxin-1 (trx1) expression might be involved in stomach carcinogenesis in vitro. to study histopathological changes of the stomach mucosa in vivo, a mongolian gerbil model infected with h. pylori with high trx1 expression was established. | 2016 | 26669590 |
| ureases as multifunctional toxic proteins: a review. | ureases are metalloenzymes that hydrolyze urea into ammonia and carbon dioxide. they were the first enzymes to be crystallized and, with them, the notion that enzymes are proteins became accepted. novel toxic properties of ureases that are independent of their enzyme activity have been discovered in the last three decades. since our first description of the neurotoxic properties of canatoxin, an isoform of the jack bean urease, which appeared in toxicon in 1981, about one hundred articles have b ... | 2016 | 26690979 |
| risk factors for central serous chorioretinopathy: a systematic review and meta-analysis. | central serous chorioretinopathy (csc) is a common retina disease and has a relative high recurrence rate, etiology, and pathogenesis of which remains ambiguous. the systematic review and meta-analysis aimed to measure risk factors for csc in a quantitative method, providing some precautions and interventions on this disease and preventing further recurrences. | 2016 | 26710181 |
| changes in gastric microbiota induced by helicobacter pylori infection and preventive effects of lactobacillus plantarum zdy 2013 against such infection. | helicobacter pylori is a gram-negative pathogen linked to gastric ulcers and stomach cancer. gastric microbiota might play an essential role in the pathogenesis of these stomach diseases. in this study, we investigated the preventive effect of a probiotic candidate lactobacillus plantarum zdy 2013 as a protective agent against the gastric mucosal inflammation and alteration of gastric microbiota induced by h. pylori infection in a mouse model. prior to infection, mice were pretreated with or wit ... | 2016 | 26709179 |
| prostate stem cell antigen gene tt genotype and development of intestinal metaplasia in helicobacter pylori infection. | gastric cancer is etiologically related to interactions between helicobacter pylori (h. pylori) infection, environmental and host factors. gastric carcinoma is associated with a cascade of increasing atrophic gastric mucosal damage. prostate stem cell antigen (psca) polymorphisms have been associated with an increased risk of gastric cancer. we aimed to examine the interaction between psca polymorphisms and h. pylori in the progression of h. pylori-related gastritis. | 2016 | 26706772 |
| eradicating multi-drug-resistant helicobacter pylori with four times daily lansoprazole. | 2016 | 26706384 | |
| gastro protective and h(+), k(+)-atpase/h. pylori inhibitory properties of pectic polysaccharides from potato. | polysaccharide is one among the important classes of biological polymers that is reported to exhibit disease preventive properties. the present study describes the isolation of galactans and confirmation of the same by sugar analysis and determination of anti-ulcer effect of potato galactan polysaccharide (pgp). data indicated that pgp possessed sugar composition of rhamnose (2%), arabinose (3%), mannose (3%), galactose (94%) and uronic acid (17%) confirming that pgp thus isolated is a galactan. ... | 2016 | 26704999 |
| let-7c down-regulation in helicobacter pylori-related gastric carcinogenesis. | aberrant let-7c microrna (mirna) expression has been observed in helicobacter pylori-related gastric cancer (gc) but fragmentary information is available on the let-7c dysregulation occurring with each phenotypic change involved in gastric carcinogenesis. let-7c expression was assessed (qrt-pcr) in a series of 175 gastric biopsy samples representative of the whole spectrum of phenotypic changes involved in h. pylori-related gastric oncogenesis including: i) normal gastric mucosa, as obtained fro ... | 2016 | 26701848 |
| finding gastric cancer related genes and clinical biomarkers for detection based on gene-gene interaction network. | gastric cancer (gc) is the second leading cause of death resulted from cancer globally. the most common cause of gc is the infection of helicobacter pylori, approximately 11% of cases are caused by genetic factors. the objective of this study was to develop an effective computational method to meaningfully interpret these gc-related genes and to predict potential prognostic genes for clinical detection. | 2016 | 26700107 |
| mass eradication of helicobacter pylorito prevent gastric cancer: theoretical and practical considerations. | although the age-adjusted incidence of gastric cancer is declining, the absolute number of new cases of gastric cancer is increasing due to population growth and aging. an effective strategy is needed to prevent this deadly cancer. among the available strategies, screen-and-treat for helicobacter pylori infection appears to be the best approach to decrease cancer risk; however, implementation of this strategy on the population level requires a systematic approach. the program also must be integr ... | 2016 | 26696028 |
| review article: the global emergence of helicobacter pylori antibiotic resistance. | helicobacter pylori is one of the most prevalent global pathogens and can lead to gastrointestinal disease including peptic ulcers, gastric marginal zone lymphoma and gastric carcinoma. | 2016 | 26694080 |
| expression of interleukin 1β in gastric cancer tissue and its effects on gastric cancer. | this study detected the expression level of il-1β in gastric cancer tissue and paracarcinoma tissue, and also analyzed its relationship with clinical and pathological features, so as to explore the expression of il-1β in gastric cancer tissue and its effect on gastric cancer. a total of 70 fresh primary gastric cancer tumors and corresponding paracarcinoma tissues away from the tumor-incision edge (≥5 cm) were selected from the first affiliated hospital of zhengzhou university from january to de ... | 2016 | 26730201 |
| oxyntic gastric atrophy in helicobacter pylori gastritis is distinct from autoimmune gastritis. | to assess characteristics of oxyntic gastric atrophy (oga) in autoimmune gastritis (aig) compared with oga as a consequence of helicobacter pylori infection. | 2016 | 26729016 |
| rnase j depletion leads to massive changes in mrna abundance in helicobacter pylori. | degradation of rna as an intermediate message between genes and corresponding proteins is important for rapid attenuation of gene expression and maintenance of cellular homeostasis. this process is controlled by ribonucleases that have different target specificities. in the bacterial pathogen helicobacter pylori, an exo- and endoribonuclease rnase j is essential for growth. to explore the role of rnase j in h. pylori, we identified its putative targets at a global scale using next generation rna ... | 2016 | 26726773 |
| clarithromycin resistance and 23s rrna gene point mutations of helicobacter pylori infection in children. | this study aims to evaluate helicobacter pylori with clarithromycin resistant genotypes in manisa region, turkey. two hundred patients, who received diagnosis of helicobacter pylori infection histopathologically, were included. the sex, age and endoscopy indications of the patients were recorded. polymerase chain reaction method was applied to determine the clarithromycin resistance rate and resistance genotypes at the histologic sections prepared from gastric biopsies that had been embedded in ... | 2016 | 28276208 |
| quantitative analysis of caga type iv secretion by helicobacter pylori reveals substrate recognition and translocation requirements. | bacterial type iv secretion systems are protein transporters with a remarkable diversity of substrates and substrate recognition mechanisms. type iv-secreted proteins often contain c-terminal secretion signals, but may also require other regions for recognition as secretory substrates, or for full secretion efficiency. for example, type iv secretion of caga, a major pathogenicity factor of the human gastric pathogen helicobacter pylori, depends on a c-terminal signal and on n-terminal protein re ... | 2016 | 26713727 |
| carbohydrate metabolism improvement after helicobacter pylori eradication. | 2016 | 26712113 | |
| synthesis, structures and urease inhibitory activity of cobalt(iii) complexes with schiff bases. | a series of new cobalt(iii) complexes were prepared. they are [col(1)(py)3]·no3 (1), [col(2)(bipy)(n3)]·ch3oh (2), [col(3)(hl(3))(n3)]·no3 (3), and [col(4)(meoh)(n3)] (4), where l(1), l(2), l(3) and l(4) are the deprotonated form of n'-(2-hydroxy-5-methoxybenzylidene)-3-methylbenzohydrazide, n'-(2-hydroxybenzylidene)-3-hydroxylbenzohydrazide, 2-[(2-dimethylaminoethylimino)methyl]-4-methylphenol, and n,n'-bis(5-methylsalicylidene)-o-phenylenediamine, respectively, py is pyridine, and bipy is 2,2' ... | 2016 | 26712097 |
| density of tryptase-positive mast cells correlated with the presence of h. pylori in gastric neoplasia. | gastric cancer continues to be a platoon leader of mortality causes. a significant number of recent studies show direct or indirect involvement of mast cells (mc), with a complex role both pro- and anti-tumor growth. | 2016 | 26710498 |
| crystal structure of hint from helicobacter pylori. | proteins belonging to the histidine triad (hit) superfamily bind nucleotides and use the histidine triad motif to carry out dinucleotidyl hydrolase, nucleotidyltransferase and phosphoramidite hydrolase activities. five different branches of this superfamily are known to exist. defects in these proteins in humans are linked to many diseases such as ataxia, diseases of rna metabolism and cell-cycle regulation, and various types of cancer. the histidine triad nucleotide protein (hint) is nearly ide ... | 2016 | 26750483 |
| the role of routine upper gastrointestinal endoscopy before bariatric surgery. | obesity remains a major health concern for which surgery has proven to be the most effective treatment in the long term. routine upper gastrointestinal endoscopy (uge) is recommended before surgery, but few studies have evaluated its impact on postoperative complications. | 2016 | 26750117 |
| helicobacter pylori infection in patients with selective immunoglobulin a deficiency. | selective immunoglobulin a (iga) deficiency (igad) is the most common primary immunodeficiency in the western world. the aim of the study was to investigate the prevalence and clinical characteristics of helicobacter pylori-infected dyspeptic patients with igad. case samples were drawn from all subjects ≥ 12 years of age (n = 104729) who had undergone serum total iga measurements during 2004-14 for any reason at leumit healthcare services (israel) and had serum total iga < 0·07 g/l. the control ... | 2016 | 26749258 |
| adenoid hypertrophy and chronic rhinosinusitis: helicobacter pylori on antral lavages, adenoid tissue and salival inmunoglobuline a on paediatric patients. | to determine helicobacter pylori presence on antral lavages, adenoids and salival inmunoglobuline a on paediatric patients with chronic rhinosinusitis without nasal polyps (crssnp) and adenoid hypertrophy. | 2016 | 26746618 |
| proteomics-based identification and analysis of proteins associated with helicobacter pylori in gastric cancer. | helicobacter pylori (h. pylori) is a spiral-shaped gram-negative bacterium that causes the most common chronic infection in the human stomach. approximately 1%-3% of infected individuals develop gastric cancer. however, the mechanisms by which h. pylori induces gastric cancer are not completely understood. the available evidence indicates a strong link between the virulence factor of h. pylori, cytotoxin-associated gene a (caga), and gastric cancer. to further characterize h. pylori virulence, w ... | 2016 | 26745502 |