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improved sensitivity for long-distance measurements in biomolecules: five-pulse double electron-electron resonance.we describe significantly improved long-distance measurements in biomolecules by use of the new multipulse double electron-electron spin resonance (deer) illustrated with the example of a five-pulse deer sequence. in this sequence, an extra pulse at the pump frequency is used compared with standard four-pulse deer. the position of the extra pulse is fixed relative to the three pulses of the detection sequence. this significantly reduces the effect of nuclear spin-diffusion on the electron-spin p ...201223301118
[iodine and thyroid gland with or without nuclear catastrophe].iodine, as a trace element, is a necessary and limiting substrate for thyroid gland hormone synthesis. it is an essential element that enables the thyroid gland to produce thyroid hormones thyroxine (t4) and triiodothyronine (t3). synthesis of thyroid hormones and iodine metabolism. three iodine molecules are added to make triiodothyronine, and four for thyroxine - the two key hormones produced by the thyroid gland. iodine deficiency the proper daily amount of iodine is required for optimal thyr ...201223297615
[analysis of mosaic expression of the nptii gene in transgenic tobacco plant lines contrasting in mosaicism].differences in the frequency of occurrence of plants with the mosaic phenotype between the nu5 and nu6 lines of transgenic tobacco (nicotiana tabacum) plants remained irrespective of the allelic state of the nptii marker gene. transition of the nptii gene from the hemizygous state (t3) to the homozygous state (t4) was accompanied by an increase in the frequency of mosaics in both lines. transition from the homozygous state (t4) into the hemizygous state (f1) resulted in a further increase in the ...201223297483
congenital hypothyroidism: a review of the risk factors.this study was aimed to evaluate the situation of congenital hypothyroidism (ch) in guilan using the screening program and determine the correlation of ch with birth weight, gestational age and seasonality. during 2006 to 2010, in guilan province, neonatal screening for ch by measurement of serum tsh level was performed in 3-5 days after birth. all neonates with tsh level ≥ 5mu/l were referred to endocrinologists and serum tsh, t3 and t4 were measured. based on public health data and profiles, t ...201223292624
distribution of contrast medium epidurally injected at thoracic and lumbar vertebral segments.the epidural distribution of iohexol (0.2 ml/kg) administered at thoracic vertebrae (thoracic group) and lumbar vertebrae (lumbar group) was compared by computed tomographic (ct) epidurography in dogs. the total spread of iohexol was similar between the 2 groups upon reaching a similar cranial level. the maximal ct values were higher at the c7/t1 and t4/t5 levels in thoracic group, but they were higher at the t13/l1 and l4/l5 levels in lumbar group (p<0.05). this result suggests that the distrib ...201223292108
detection of t4 polynucleotide kinase activity with immobilization of tio2 nanotubes and amplification of au nanoparticles.determination of nucleotide kinase activity is valuable due to its importance in regulating nucleic acid metabolism. herein, we describe a strategy for simply and accurately determining nucleotide kinase activity by tio2 nanotubes mediated signal transition and au nanoparticles amplification. in this method, dna containing 5'-hydroxyl group is self-assembled onto a gold electrode and used as a substrate for t4 polynucleotide kinase (pnk). by the specific immobilization affinity of tio2 nanotubes ...201223291616
[subcarinal lymph node metastasis and strategy of lymphadenectomy in thoracic esophageal carcinoma].to assess the metastatic frequency of subcarinal lymph nodes of thoracic esophageal carcinoma and its influencing factors, in order to determine the adequate range of lymph node dissection during esophagectomy.201223291134
association between osteopontin and egfr expression with clinicopathological parameters in hepatocellular carcinoma.osteopontin (opn) and epidermal growth factor receptor (egfr) are important factors associated with tumor progression, invasion and metastasis in humans. the aim of this study was to assess the correlation of opn and egfr expression with hepatocellular carcinoma (hcc) progression. expression of opn and egfr was assessed by immunohistochemistry in 100 hcc specimens. immunostaining scores (0 to 400) were calculated from the percentage of cells (0 to 100) at each immunostaining intensity and the im ...201223286449
[immunological characteristics in subjects with heart connective tissue dysplasia depending on thyroid hormone levels and vegetative dysfunction].patients with heart connective tissue dysplasia (hctd) are known to be subject to infectious and inflammatory diseases due to peculiarities of their immune system. we studied 181 patients with hctd depending on thyroid hormone levels and vegetative dysfunction. hctd was shown to be associated with a significant decrease of igm levels and increase of circulating immune complexes. the igg level in patients with mitral valve prolapse (mvp), anomalous chord localization, and combination of mpv and t ...201223285764
[the influence of subclinical thyroid dysfunction on cardiac hemodynamic and electrophysiological parameters in patients with coronary heart disease and paroxysmal atrial fibrillation].the study included 58 patients with chd and paroxysmal atrial fibrillation divided into 2 groups depending on thyroid hormone and thyrotropin levels. group 1 was comprised of 24 patients with subclinical hypothyroidism, group 2 of 18 ones with subclinical hyperthyroidism. control group consisted of l6 patients with chd, paroxysmal atrial fibrillation and normal thvroid function. it was shown that patients with chd, paroxysmal atrial fibrillation and subclinical thyrotoxicosis had t3 and t4 level ...201223285759
[radio and chemotherapy in gallbladder cancer: a latin american consensus].no randomized controlled trials have been conducted in gallbladder cancer to establish standard treatments. we therefore conducted the first latin american consensus meeting for the management of gallbladder cancer. in this paper we report the conclusions of the experts' panel for (neo) adjuvant treatment of resectable gallbladder cancer. these are based on the review of the literature, the discussion of the participating experts and the vote of the assistants (surgical oncologists, medical onco ...201223282782
endoscopic ultrasound in restaging and predicting pathological response for advanced gastric cancer patients after neoadjuvant chemotherapy.aim: to evaluate the role of endoscopic ultrasound (eus) in restaging and predicting response after neoadjuvant chemotherapy in patients with advanced gastric cancer. methods: in all, 48 advanced gastric cancer patients were recruited from june 2007 to december 2010 after providing their written, informed consent. all patients underwent an eus before and after three cycles of neoadjuvant chemotherapy (folfox 6), and then a radical resection was performed 3-4 weeks after chemotherapy. the results ...201223279745
comparison between cranial thoracic intervertebral disc herniations in german shepherd dogs and other large breed dogs.cranial thoracic intervertebral disc herniations have been reported to be rare in dogs due to the presence of the intercapital ligament, however some studies have proposed they may not be uncommon in german shepherd dogs. the purpose of this retrospective study was to compare cranial thoracic intervertebral disc herniations in german shepherd dogs and other large breed dogs (control group). medical records at the ontario veterinary college were searched for german shepherd dogs and other large b ...201223278950
cryoelectron microscopy analysis of small heat shock protein 16.5 (hsp16.5) complexes with t4 lysozyme reveals the structural basis of multimode binding.small heat shock proteins (shsps) are ubiquitous chaperones that bind and sequester non-native proteins preventing their aggregation. despite extensive studies of shsps chaperone activity, the location of the bound substrate within the shsp oligomer has not been determined. in this paper, we used cryoelectron microscopy (cryoem) to visualize destabilized mutants of t4 lysozyme (t4l) bound to engineered variants of the small heat shock protein hsp16.5. in contrast to wild type hsp16.5, binding of ...201223277356
thyroid hormones and erythrocyte indices in a cohort of euthyroid older subjects.hypothyroidism is associated with normocytic anaemia. indeed, a limited number of studies have shown significant associations between free thyroxin (t4) and erythrocyte indices. these studies did not include vitamin b12, folic acid, iron and renal function in the analyses. we therefore studied the association between thyroid hormones and erythrocyte indices in a population-based cohort of older euthyroid subjects, with adjustment for major confounding parameters.201223276452
eplt4 proteinaceous elicitor produced in pichia pastoris has a protective effect against cercosporidium sofinum infections of soybean leaves.a complementary dna library was constructed from the mycelium of trichoderma asperellum t4, and a highly expressed gene fragment named eplt4 was found. in order to find a more efficient and cost-effective way of obtaining eplt4, this study attempted to produce eplt4 using a pichia pastoris expression system. the gene encoding eplt4, with an additional 6-his tag at the c-terminus, was cloned into the yeast vector ppic9k and expressed in the p. pastoris strain gs115 to obtaining more protein for t ...201223271623
[clinical analysis of patients with stage iv ( colorectal cancer after palliative resection of primary tumor].to investigate the independent predictors of postoperative mortality, morbidity, and long-term survival in patients with stage iv ( colorectal cancer.201223268278
a survey of host range genes in poxvirus genomes.poxviruses are widespread pathogens, which display extremely different host ranges. whereas some poxviruses, including variola virus, display narrow host ranges, others such as cowpox viruses naturally infect a wide range of mammals. the molecular basis for differences in host range are poorly understood but apparently depend on the successful manipulation of the host antiviral response. some poxvirus genes have been shown to confer host tropism in experimental settings and are thus called host ...201223268114
[evaluation of chemoradiotherapy for stage ii and iii( non-t4) esophageal cancer].we retrospectively evaluated the clinical efficacy of chemoradiotherapy for surgically resectable stage ii and iii (non-t4) esophageal cancer.201223267987
[complete response obtained by preoperative chemotherapy in a case of t4 rectal cancer].a 48-year-old man, who had presented with anal pain and cloudy urine, was referred to our hospital. colonoscopy showed a type 2 circular tumor at the higher rectum, and a diagnosis of well-differentiated adenocarcinoma was made by biopsy. ct demonstrated increased thickness of the rectum wall, an equivocal boundary between the rectum and the bladder, and abnormal gas production in the bladder. following diagnosis of t4 rectal cancer, preoperative chemotherapy was initiated with the aim of downst ...201223267941
[a case of advanced hepatocellular carcinoma with tumor thrombosis in the main trunk of the portal vein successfully treated by multidisciplinary therapies].we report a case of advanced hepatocellular carcinoma(hcc) with tumor thrombosis in the main trunk of the portal vein successfully treated by multidisciplinary therapies. this case is that of a 61-year-old man with loss of appetite and weight loss. the abdominal computed tomography revealed an early enhanced and late wash-out lesion in the right hepatic lobe and tumor thrombosis in the major trunk of the portal vein. we diagnosed advanced hcc related to chronic hepatitis c [t4 (vp4) n0m0, stage ...201223267913
effect of corticosterone on growth and welfare of broiler chickens showing long or short tonic immobility.tonic immobility (ti) test is commonly used to assess fear. animals showing different ti durations demonstrate distinct behavior and biochemical responses to stress. however, less is known about how ti phenotype affects growth and welfare of domestic fowl. in this study, broiler chickens (gallus gallus) were classified into short and long ti duration (sti and lti) phenotypes and treated chronically with vehicle (con) or corticosterone (cort). sti broilers demonstrated significantly higher growth ...201223266338
surgical treatment of ossification of the ligamentum flavum associated with dural ossification in the thoracic spine.between january 2006 and december 2009, dural ossification (do) was found intraoperatively in 26 of 98 patients with thoracic spinal stenosis due to ossification of the ligamentum flavum (olf). mri showed single-level (n = 2), two-level (n = 8) and multilevel (n = 16) areas of low signal intensity in the ligamentum flavum of the thoracic spine. of the 68 ossified segments in the study population, 11 (16.2%) were located in the upper thoracic spine (t1-t4), nine (13.2%) were located in the midtho ...201223266313
the prognostic significance of hypoxia inducing factor 1-α in oropharyngeal cancer in relation to human papillomavirus status.this study examines the prognostic significance of hypoxia inducing factor-1α (hif-1α) expression in relation to human papillomavirus (hpv) status in oropharyngeal squamous cell carcinoma (scc).201223266008
the incidence of interval cancers in the german mammography screening program: results from the population-based cancer registry in north rhine-westphalia.cancer screening programs must meet high standards for quality and effectiveness, because many healthy persons need to be screened to detect relatively few cases of cancer. in this study, we use the rate of interval cancers as an important surrogate indicator for evaluating the german mammography screening program (msp).201223264826
the link between thyroid function and depression.the relation between thyroid function and depression has long been recognized. patients with thyroid disorders are more prone to develop depressive symptoms and conversely depression may be accompanied by various subtle thyroid abnormalities. traditionally, the most commonly documented abnormalities are elevated t4 levels, low t3, elevated rt3, a blunted tsh response to trh, positive antithyroid antibodies, and elevated csf trh concentrations. in addition, thyroid hormone supplements appear to a ...201222220285
differences of the lymphatic distribution and surgical outcomes between remnant gastric cancers and primary proximal gastric cancers.background: although remnant gastric cancer (rgc) following distal gastrectomy is located in the proximal stomach, little is known about the differences of the lymphatic distribution and surgical outcomes between rgc and primary proximal gastric cancer (pgc). methods: between 1997 and 2008, 1,149 patients underwent gastrectomy for gastric cancer. of these, 33 (2.9%) rgc patients and 207 (18.5%) pgc patients were ...201222215245
comparison of clinical outcomes for patients with large choroidal melanoma after primary treatment with enucleation or proton beam radiotherapy.purpose: to evaluate survival and clinical outcome for patients with a large uveal melanoma treated by either enucleation or proton beam radiotherapy (pbrt). procedures: this retrospective non-randomized study evaluated 132 consecutive patients with t3 and t4 choroidal melanoma classified according to tnm stage grouping. results: cumulative all-cause mortality, melanoma-related mortality and metastasis-free survival were not statistically different between the two groups (log-rank test, p = 0.56 ...201222269846
the determining risk factors for treatment outcomes in patients with squamous cell carcinoma of the hard palate.background: the determining risk factors for patients with squamous cell carcinoma of the hard palate are not well verified. methods: medical records from our facility of all patients with squamous cell carcinoma of the hard palate receiving curative surgery between march 2003 and may 2009 were reviewed. results: seventy-eight patients were enrolled in ...201222271207
endoscopic vs transfacial resection of sinonasal adenocarcinomas.objectives. compare the survival and the complication rates of 2 comparable groups of patients who underwent either endoscopic or transfacial resection of a sinonasal adenocarcinoma.study design. historical cohort study.setting. tertiary referral center.subjects and methods. twenty-four patients with sinonasal adenocarcinomas who recently underwent an endoscopy (the endo group, 1999-2009) were compared with 24 patients who underwent a lateral rhinotomy procedure (the lr group, 1993-2007). the pr ...201222261496
spontaneus bilateral pedicle fracture 30 years after harrington instrumentation for idiopathic scoliosis: a case report.abstract: introduction: spontaneous fractures of the spine are a common entity. they usually occur in older people with osteoporosis. this case is presented on account of its rarity. to the best of the authors' knowledge only one case of an osteoporotic pedicle fracture after harrington instrumentation has been described before. case presentation: we report the case of a 46-year-old caucasian woman who underwent surgery due to idiopathic scoliosis with a harrington instrumentation (t4 to l3) 3 ...201222269652
creation and validation of a ligation-independent cloning (lic) retroviral vector for stable gene transduction in mammalian cells.abstract: background: cloning vectors capable of retroviral transduction have enabled stable gene overexpression in numerous mitotic cell lines. however, the relatively small number of feasible restriction enzyme sequences in their cloning sites can hinder successful generation of overexpression constructs if these sequences are also present in the target cdna insert. results: utilizing ligation-independent cloning (lic) technology, we have modified the highly efficient retroviral transduction ...201222248071
a longitudinal assessment of early pubertal timing as a predictor of psychosocial changes in adolescent girls with and without spina bifida.objective: a longitudinal comparison of adolescent girls with and without spina bifida (sb), regarding the effects of early pubertal timing on girls' depressive symptoms, mother-daughter conflict, and emotional distancing. methods: 62 mother-daughter dyads (31 with sb and 31 without) reported on psychosocial outcomes at 5 time points (ages 8/9 to 16/17 years). results: a pubertal timing × sb status interaction predicted emotional distancing (t2), conflict (t2, t5), and depressive symptoms (t4) ...201222271794
deletion of the rnaseiii enzyme dicer in thyroid follicular cells causes hypothyroidism with signs of neoplastic alterations.micro-rnas (mirnas) are small non-coding rnas that regulate gene expression, mainly at mrna post-transcriptional level. functional maturation of most mirnas requires processing of the primary transcript by dicer, an rnaseiii-type enzyme. to date, the importance of mirna function for normal organogenesis has been demonstrated in several mouse models of tissue-specific dicer inactivation. however, the role of mirnas in thyroid development has not yet been addressed. for the present study, we gener ...201222242190
low concentrations of bisphenol a suppress thyroid hormone receptor transcription through a nongenomic mechanism.bisphenol (bpa) is one of the highest-volume chemicals produced worldwide, and human exposure to bpa is thought to be ubiquitous. various rodent and in vitro studies have shown that thyroid hormone (th) function can be impaired by bpa. however, it is still unknown if low concentrations of bpa can suppress the thyroid hormone receptor (tr) transcription. the present study aims to investigate the possible suppressing effects of low concentrations of bpa on tr transcription and the involved mechani ...201122227104
thyroid hormonal disturbances related to treatment of hepatitis c with interferon-alpha and ribavirin.to characterize thyroid disturbances induced by interferon-alpha and ribavirin therapy in patients with chronic hepatitis c.201122012048
3,5-diiodo-l-thyronine increases resting metabolic rate and reduces body weight without undesirable side effects.recently, it was demonstrated that 3,5-diiodo-l-thyronine (t2) stimulates the resting metabolic rate (rmr), and reduces body-weight gain of rats receiving a high-fat diet. the aim of this study is to examine the effects of chronic t2 administration on basal metabolic rate and body weight in humans. two euthyroid subjects volunteered to undergo t2 administration. body weight, body mass index, blood pressure, heart rate, electrocardiogram, thyroid and liver ultrasonography, glycemia, total cholest ...201122217997
effectiveness of adjuvant chemotherapy with 5-fu/leucovorin and prognosis in stage ii colon cancer.the aims of this study were to investigate the survival results and the prognostic factors of adjuvant chemotherapy in stage ii colon cancer in the sparsity of korean data.201122259748
anaesthesia management for thyroidectomy in a non-euthyroid patient following cardiac failure.a 24-year-old male thyrotoxic student of a tertiary institution had thyroidectomy in the presence of a persistently elevated thyroxine (t4) and tri-iodothyronine (t3) levels. he was initially managed for hypertension at a private hospital before he was referred to our hospital for expert management. he had symptoms of thyrotoxicosis three years before presentation at our hospital. physical examination revealed bilateral anterior neck masses and a diagnosis of toxic goitre was made. the serum t3 ...201122248956
tsh neurosecretory dysfunction (tsh-nd) in down syndrome (ds): low risk of progression to hashimoto's thyroiditis.patients with down syndrome (ds) often have elevated tsh (hypothalamic origin), which is called tsh neurosecretory dysfunction (tsh-nd). in these cases, there is slight elevation in tsh (5-15 µui/ml), with normal free t4 and negative thyroid antibodies (ab).201122218446
[myoepithelial carcinoma of salivary glands: a clinical analysis of 13 cases].this study retrospectively analyzed the clinical data of 13 patients with myoepithelial carcinoma of salivary glands for improving the accuracy of diagnosis and treatment outcome.201122241311
treatment of hypothyroidism due to iodine deficiency using daily powdered kelp in patients receiving long-term total enteral nutrition.we investigated thyroid function and urinary iodine concentration (uic) in seven patients with severe motor intellectual disabilities. all seven received total enteral nutrition (ten) for more than three years with a daily iodine intake of less than 20 µg. they were diagnosed as hypothyroidism due to iodine deficiency (hid) because of high tsh levels (7.6-82.3 µiu/ml), lower free t4 (ft4 0.4-1.5 ng/dl), negative anti-thyroid antibodies (anti-thyroglobulin antibody, anti-thyroidal peroxidase anti ...201123926395
nutritional and toxicological assessment of white-rot fermented animal feed.the fungal fermented wheat straws as animal feeds have been evaluated for its toxicological and nutritional status in male rats (holtzman strain). digestibility of dry matter and other nutrients as well as fiber fractions were found significantly higher (p < 0.05) in straw fermented with either ganoderma sp. rckk02 (t3) or crinipellis sp. rck-1 (t4) than unfermented straw (t1) or straw fermented with pycnoporus cinnabarinus (t2). the aflatoxin b1, b2, g1 and g2 were either absent or present in p ...201123729880
changes of serum trace elements, afp, cea, sf, t3, t4 and igf-ii in different periods of rat liver cancer.based on liver cancer model built in sd rats, the contents of trace elements (cu, fe, zn, ca and mg), afp, cea, sf, th and igf-ii in serum were measured at different stages to explore the molecular changes during the rat liver cancer development.201123357927
[viability and efects of the probiotic lactobacillus aracaseissp aracasei in chilean low-fat gauda cheese].the objective of this study is to infer the survival of the probiotic lactobacillus paracasei ssp paracasei added during the processing of low-fat gouda cheese, during the maturation (21 days) and the commercialization (14 days), in order to see the influence that this organism has on the quality of the product. the treatments were: ti (control): gouda with normal fat content; t2: low fat gouda cheese (qgs) t3: qgs, with additional probiotic added with the initial culture; t4: qgs, with the prob ...201123094525
expression of p-akt and p-mtor in a large series of bronchopulmonary neuroendocrine tumors.bronchopulmonary neuroendocrine tumors (bp-nets) are separated into four subgroups: typical carcinoid tumor (tc), atypical carcinoid tumor (ac), large-cell neuroendocrine carcinoma (lcnec) and small-cell lung carcinoma (sclc). the signaling pathway involving akt/mammalian target of rapamycin (mtor) is crucial to the regulation of cell growth, proliferation and survival, and is frequently activated in human cancers. consequently, mtor is considered an attractive target for anticancer agents. the ...201122977576
subclinical hypothyroidism in childhood obesity and its correlation with lipoproteins.there is an ongoing debate regarding the influence of subclinical hypothyroidism on body mass index. the objectives of the study were (i) to determine whether levels of thyroid stimulating hormone (tsh) are elevated in obese children, (ii) to compare the serum levels of triiodothyronine (t3) and thyroxine (t4) in obese with non-obese and (iii) to examine the association of subclinical hypothyroidism with lipoproteins and body mass index.201122783686
chemoradiation in advanced head and neck cancers: a comparison of two radiosensitizers, paclitaxel and cisplatin.to compare the locoregional control rates, survival outcome and toxicity profiles between two groups of patients of squamous cell carcinoma (scc) of head and neck (stage iii & iv) receiving concomitant chemo-radiotherapy with paclitaxel and cisplatin. a prospective study was done on 94 previously untreated patients of histopathologically proved squamous cell carcinoma of head and neck region-ajcc stage iii & iv (t3 & t4 with n0 -n3, m0) treated with concomitant chemoradiation. the patients were ...201122754800
surgical treatment of papillary thyroid carcinoma.papillary carcinoma accounts for 85% of differentiated thyroid cancers. we witness a yearly increased incidence and this is may be, in part, due to the increasing use of neck ultrasonography. certain histologic subtypes of papillary carcinoma have a worse prognosis related to vascular invasion, invasion into extrathyroidal tissues, extensive tumor necrosis and/or mitoses. adequate surgery is the most important treatment variable influencing prognosis, while radioactive iodine treatment, tsh supp ...201122746009
successful bortezomib treatment in combination with dexamethasone and thalidomide for previously untreated epidural plasmacytoma.epidural plasmacytoma is a rare clinical entity of plasma cell neoplasms. the optimal management of extra medullary plasmacytoma remains unclear, particularly for bulky masses. in this study, we report the case of a 35-year-old male who presented with the inability to walk, urinary incontinence and superficial and deep sensory disturbance. spinal magnetic resonance imaging revealed a large epidural mass compressing the spinal cord at the level of t2-t4. the patient underwent surgical t2-t4 verte ...201122740951
copy number changes of crisp3 in oral squamous cell carcinoma.the aim of this study was to identify tumor suppressor genes (tsgs) in oral squamous cell carcinoma (oscc) using whole-genome analysis of microarray technology and real-time quantitative polymerase chain reaction (qpcr). we applied whole-genome analysis of tsgs in the specimens from 3 patients of oscc by microarray technology. a total of 11 genes, crisp3, scgb3a1, agr2, pip, c20orf114, tff1, stath, azgp1, muc7, dmbt1 and loc389429, were found to be down-regulated, and 2, matrix metallopeptidase ...201122740859
correlation of metabolism/hypoxia markers and fluorodeoxyglucose uptake in oral squamous cell carcinomas.the objective of this study was to analyze the relationship between the uptake of (18)f-2-fluoro-2-deoxy-d-glucose (fdg) by positron emission tomography-computerized tomography (pet-ct) and glucose metabolism/hypoxia markers in oral squamous cell carcinoma (oscc).201122676927
triiodothyronin, thyroxine and thyrotropin in vitiligo.vitiligo is a common pigmentary disorder of the skin, affecting individuals globally. not only is this ailment psychologically incapacitating, it also has a high incidence of autoimmunity, signifying that its manifestations may be the portrayal of dysfunction of immune system.201122610860
incidence of incidental carcinoma gall bladder in cases of routine cholecystectomy.carcinoma of gall bladder is the most common malignancy of the billiary tract. most of the cases are diagnosed as an incidental case among patients undergoing cholecystectomy.201122610859
failure patterns in patients with esophageal cancer treated with definitive chemoradiation.local failure after definitive chemoradiation therapy for unresectable esophageal cancer remains problematic. little is known about the failure pattern based on modern-day radiation treatment volumes. we hypothesized that most local failures would be within the gross tumor volume (gtv), where the bulk of the tumor burden resides.201122565611
how common is hypothyroidism after external radiotherapy to neck in head and neck cancer patients?to identify the occurrence of clinical and subclinical hypothyroidism among head and neck cancer patients receiving radiation to the neck and to justify routine performing of thyroid function tests during follow-up.201122557780
[functional assessment of the different types of anterior cruciate ligament plasty used at the xoco general hospital arthroscopy service].currently, anterior cruciate ligament lesions have an increased frequency; their management is predominantly surgical; there are several functional assessment systems.201122512111
suppression of seizure by cathodal transcranial direct current stimulation in an epileptic patient - a case report -.epilepsy is an intractable disease, though many treatment modalities have been developed. recently, noninvasive transcranial direct current stimulation (tdcs), which can change brain excitability, was introduced and has been applied for therapeutic purposes regarding epilepsy. a suppression of seizures was experienced by cathodal tdcs in a medication refractory pediatric epileptic patient. the patient was an 11-year-old female who had focal cortical dysplasia of the cerebral hemisphere. the pati ...201122506177
craniofacial resection for sinonasal malignant tumors: statistical analysis of surgical outcome over 17 years at a single institution.we present a retrospective analysis of surgical outcome of sinonasal malignant tumors. overall survival (os), disease-specific survival (dss), local control (lc), and disease-free survival (dfs) were calculated in 32 patients. prognostic factors for survival and functional outcomes were investigated. the median follow-up period was 70 months. at 5 years, os, dss, lc, and dfs rates were 0.722, 0.745, 0.851, and 0.707, respectively. prognostic factors for poor os were involvement of the frontal si ...201122470267
concomitant chemoradiotherapy as a standard treatment for squamous cell carcinoma of the temporal bone.we sought to characterize the effectiveness of concomitant chemoradiotherapy (ccrt) for patients with squamous cell carcinoma of the temporal bone. we performed a retrospective chart review of 14 patients with cancer of the temporal bone who were provided initial treatment in our hospital from december 2001 to november 2008. four patients with stage i tumors were treated by radiation therapy alone or with oral administration of s1. one patient with a stage ii tumor was treated by radiation thera ...201122451818
single-molecule studies of viral dna packaging.assembly of many dsdna viruses involves packaging of dna molecules into pre-assembled procapsids by portal molecular motor complexes. techniques have recently been developed using optical tweezers to directly measure the packaging of single dna molecules into single procapsids in real time and the forces generated by the molecular motor. three different viruses, phages phi29, lambda, and t4, have been studied, revealing interesting similarities and differences in packaging dynamics. single-molec ...201122440623
the effects of short-term manipulation of thyroid hormone status coinciding with primary wool follicle development on fleece characteristics in merino sheep.thyroidectomy surgery performed late in gestation results in perturbations in wool follicle development in foetal sheep, showing the importance of thyroid hormones for wool follicle development. the aim of this study was to determine the influence of transient manipulation of thyroid hormone status at a time corresponding with foetal primary wool follicle initiation. pregnant merino ewes (n = 12 per treatment) were treated daily between gestational days 55 and 64 with control (vehicle), exogenou ...201122440286
shelf life study of fresh celery (apium graveolens l.) grown under different nitrogen fertilization treatments.nitrogen fertilization is useful for obtaining higher growth and quality of productions, and the use of nitrogen fertilization is widespread. to evaluate the influence of nitrogen-rich fertilizers on quality characteristics of celery, shelf life tests of celery grown with 2 levels of nitrogen and 2 different nitrogen fertilizers were performed. the treatments of the celery samples were identified as follows: t1, mineral nitrogen (80 kg ha(-1)); t2, mineral nitrogen (120 kg ha(-1)); t3, organic n ...201122417367
study of the effects of hydrogen cyanide exposure in cassava workers.hydrogen cyanide is the chemical responsible for tissue hypoxia. chronic exposure to hcn may cause neurological, respiratory, cardiovascular and thyroid defects. onset of symptoms depends on dose and duration of exposure. large scale of cassava processing could be disastrous due to discharge of hydrocyanic acid into the air. cassava processing is the major industrial work in and around salem. hence the present study is taken to assess the effects of hcn exposure in cassava workers.201122412292
[subclinical hypothyroidism and cardiovascular risk factors].to determine the prevalence of subclinical hypothyroidism in the general population of an urban health center and describe the clinical characteristics and cardiovascular risk factors in patients with subclinical hypothyroidism.201122411383
extradural en-plaque spinal meningioma with intraneural invasion.extradural spinal meningiomas are rare. our understanding of purely extradural spinal meningiomas is incomplete because most reports rarely differentiate purely extradural meningiomas from extradural meningiomas with an intradural component. occasionally, reports have described involvement of the adjacent nerve root, but there has never been a description of an extradural meningioma that actually infiltrates the nerve root.201122405399
an atypical case of retropharyngeal abscess with long blind tract treated with ryle's tube drainage.a 10 year-old iban girl presented with severe odynophagia for 4 days and subcutaneous emphysema. clinically, her neck was tender with crepitus. lateral neck radiograph showed multiple linear radiolucent shadows at retropharyngeal space. flexible nasopharyngolaryngoscope revealed a tunnel behind upper oesophagus with slough and there was pooling of saliva at pyriform sinus. feeding via nasogastric tube was started and empirical treatment for fungal and bacterial infection was commenced. subsequen ...201122390112
[resistance to thyroid hormone and hashimoto's thyroiditis].resistance to thyroid hormone (rth) is a rare condition characterized by elevation of thyroid stimulating hormone (tsh) and thyroid hormones (th). its association with hashimoto's thyroiditis was described in 1993 and occurs in 1 of 1.3 million births.201122385766
effect of ramadan fasting on body composition and physical performance in female athletes.the aim of this study was to determine the effect of ramadan fasting on body composition, calorie intake and physical performance in young female athletes undertaking training sessions during ramadan.201122375235
management of severe class ii division 1 malocclusion: a case report.to describe the two-phase treatment of a preadolescent boy with a severe skeletal class ii division 1 malocclusion with vertical maxillary excess and spaced upper incisors.201122372276
prevalence of subclinical hypothyroidism among patients with acute myocardial infarction.introduction. subclinical hypothyroidism (sch) is defined as a serum thyroid-stimulating hormone (tsh) level above the upper limit of normal despite normal levels of serum free thyroxine. there is growing evidence that sch is associated with increased cardiovascular risk. we tried to investigate prevalence of sch in acute myocardial infarction patients. methods and results. we evaluate free t3, free t4, and tsh levels of 604 patients (age 58.4) retrospectively, who have been admitted to the coro ...201122363888
[ileus caused by metastasis of cutaneous malignant melanoma: case report].in this case report we describe rare metastatic appearance of cutaneous malignant melanoma ( mm) in small intestine followed by clinical appearance of acute surgical abdomen. a 42-year old women operated in our hospital in april 2009. due to unusual naevus on her right arm. pathologicaly it was mm grossly 1.5 cm, microscopically breslow 11 mm, clark's level iv (t4), number of mitosis 1.4 per mm2, without ulcerations. she was sent to continue treatment at the national referal center for melanoma ...201122359897
on-pump coronary artery bypass graft surgery: biochemical, hormonal and cellular features.the authors sought to assess biochemical, hormonal and cellular repercussions from use of cardiopulmonary bypass (cpb) in coronary artery bypass graft (cabg) surgery.201122358266
reversal of difluoromethylornithine effects by the administration of putrescine in rats.to assess the reversal of di-fluoromethyl ornithine (dfmo) effects by administration of putrescine on thyroid glands in rats.201122355995
effects of extrusion and heat treatment on the mechanical properties and biocorrosion behaviors of a mg-nd-zn-zr alloy.mechanical properties at room temperature and biocorrosion behaviors in simulated body fluid (sbf) at 37 °c of a new type of patented mg-3nd-0.2zn-0.4zr (hereafter, denoted as jdbm) alloy prepared at different extrusion temperatures, as well as heat treatment, were studied. the mechanical properties of this magnesium alloy at room temperature were improved significantly after extrusion and heat treatment compared to an as-cast alloy. the results of mechanical properties show that the yield stren ...201122340687
effects of preoperative ketamine on the endocrine-metabolic and inflammatory response to laparoscopic surgery.ketamine is hypothesized to reduce perioperative endocrine-metabolic and inflammatory responses in cardiac surgery patients. this randomized, placebo-controlled, double-blind study was performed to determine whether perioperative endocrine-metabolic and inflammatory responses are attenuated by preoperative administration of ketamine to healthy females receiving elective laparoscopic surgery.201122340231
comparison of compensatory sweating and quality of life following thoracic sympathetic block for palmar hyperhidrosis: electrocautery hook versus titanium clip.video-assisted thoracic sympathetic block is an effective, safe, and minimally invasive method for treatment of primary hyperhidrosis. the purpose of this study was to decide which one of using electrocautery hook and titanium clip is the appropriate procedure for primary palmar hyperhidrosis by assessing the compensatory sweating (cs) and quality of life (qol) of patients after sympathetic block.201122340165
[identification of nucleolar localization signal sequence of tumor metastasis suppressor gene-1].to identify the putative specific localization signal sequence of tumor metastasis suppressor gene-1 (tmsg-1) and to explore the mechanism of subcellular localization of tmsg-1 protein.201122336162
[endoscopic surgery and endoscopy-assisted surgery for the malignant transformation of sinonasal inverted papilloma].to investigate malignant transformation of sinonasal inverted papilloma (sip) treated by nasal endoscopic and endoscopy-assisted surgery.201122336018
[the clinical application of monitored anesthesia care in percutaneous dilatational tracheostomy].to investigate the changes in hemodynamics and depth of anesthesia under monitored anesthesia care (mac) in patients undergoing percutaneous dilatational tracheostomy (pdt).201122332577
breast cancer in women under 40 years of age.it is widely believed that breast cancer in young women is characterized by a relatively unfavorable prognosis and unusual pathological features. the aim of this study was to investigate clinicopathological and biological characteristics in young patients with breast cancer.201122331714
clinicopathologic significance of gastric adenocarcinoma with neuroendocrine features.composite neuroendocrine-exocrine carcinomas are malignancies that have two distinct components residing within the same tumor: an adenocarcinomatous portion and a neuroendocrine portion. this is rare in gastric cancers; however, poorly differentiated adenocarcinomas can sometimes reveal evidence of neuroendocrine features (nef) or be 'mixed endocrine and exocrine carcinomas'. this study aimed to review nef in gastric adenocarcinoma and to evaluate its prognostic significance.201122324009
[clinical observation of visual quality after implantation of toric intraocular lens].to observe the visual quality after implantation of acrysof toric intraocular lens (iol) in cataract patients.201122321501
spontaneous vacuolar degeneration of the thyroid follicular epithelium in cynomolgus monkeys.vacuolar degeneration of the thyroid follicular epithelium was observed in two untreated female cynomolgus monkeys assigned to control groups. in light microscopy, large vacuoles containing a homogenous substance occupied the basal region of the epithelium, and the nuclei had shifted toward the apical region. the vacuoles showed negative reactions to pas and thyroglobulin. electron microscopic observation revealed dilatation of the rough endoplasmic reticulum corresponding to the vacuoles. the p ...201122319235
concomitant radiotherapy and chemotherapy for high-risk nonmelanoma skin carcinomas of the head and neck.background. to report on the use and feasibility of a multimodality approach using concomitant radiotherapy and chemotherapy in patients with high-risk nonmelanoma skin carcinoma (nmsc) of the head and neck. methods. records of patients with nmsc of the head and neck who received concomitant crt at the university of north carolina between 2001 and 2007 were reviewed. results. fifteen identified patients had at least one of the following high-risk factors: t4 disease (93%), unresectability (60%), ...201122312508
central hypothyroidism following chemotherapy for acute lymphoblastic leukemia.it has been suggested that chemotherapy per se might impair the hypothalamus-pituitary-thyroid axis of childhood cancer survivors.201122308840
neurodevelopment of preterm infants born at 28 to 36 weeks of gestational age: the role of hypothyroxinemia and long-term outcome at 4 years.hypothyroxinemia in premature neonates may affect long-term neurodevelopment.201122308839
normal thyroid function in young adults who were born very preterm.there is some evidence for elevated thyrotropin (tsh) levels in children born preterm, but follow-up studies into adulthood are lacking. we tested whether thyroid function in young adults born at a gestational age < 32 weeks, with either an appropriate (appropriate for gestational age, aga) or low birth weight for gestational age (small for gestational age, sga), differed from that in age-matched controls. we made our measurements when the study participants reached 21 years of age. serum concen ...201122308837
[establishment of gynecological asthenia cold syndrome model].to establish the model of gynecological asthenia cold syndrome by simulating the etiology of gynecological asthenia cold syndrome depending on 'pathogenic cold impairing yang" in chinese medicine theory.201122303717
[effect of shenfu injection on the erythrocyte immune function of patients undergoing cardiopulmonary bypass].to observe the effect of shenfu injection (sfi) on erythrocyte immunity function of patients undergoing cardiopulmonary bypass (cpb).201122303706
patterns of differentiated thyroid cancer in baluchistan province of pakistan: some initial observations.the incidence of thyroid cancer is increasing in several countries. the main objective of this retrospective study was to find and describe province-specific estimates of incidence in males and females by age groups for differentiated thyroid cancer (dtc). this study reports on 87 cases of dtc from baluchistan province of pakistan treated with post operative radioiodine at the center for nuclear medicine and radiotherapy (cenar) quetta from january 2003 to december 2009. the patient data has bee ...201122299551
effect of anesthesia on the changes in the hormones levels during and after transvesical prostatectomy.hypovolemia and pain are direct stimulators of hormonal response to trauma. thus, neuroendocrine, metabolic and inflammatory aspects of the injury are part of an overall "stress response". in particular, it manifests in patients undergoing surgical intervention. these reactions can occur with trauma, burns, severe infections and physical exertion. metabolic and neuroendocrine response to surgical intervention depends on several factors, such as severity and duration of the surgical trauma, patie ...201122299297
nestin expression associates with poor prognosis and triple negative phenotype in locally advanced (t4) breast cancer.nestin, an intermediate filament protein, has traditionally been noted for its importance as a neural stem cell marker. however, in recent years, expression of nestin has shown to be associated with general proliferation of progenitor cell populations within neoplasms. there is no reported study addressing nestin expression in t4 breast cancer patients. thus, the aim of the present study was to investigate, through immunohistochemistry, the expression and distribution of nestin in t4 breast canc ...201122297445
[clinical observation of injection of dexmedetomidine in anaesthesia for esophageal cancer operation].to investigate the effects of administration of dexmedetomidine in anaesthesia for esophageal cancer operation.201122295535
the content of cadmium, cobalt and nickel in laryngeal carcinoma.the aim of the study was to determine the content of cadmium (cd), cobalt (co) and nickel (ni) in the samples from laryngeal carcinoma in comparison with the level of these elements in the samples of healthy mucous membrane from the same larynx.201122295038
clinical and pathological response rates of docetaxel-based neoadjuvant chemotherapy in locally advanced breast cancer and comparison with anthracycline-based chemotherapies: eight-year experience from single centre.the administration of neoadjuvant chemotherapy (nact) prior to local therapy is advantageous for women with locally advanced breast cancer (labc), since it can render inoperable tumors resectable and can increase rates of breast conservative surgeries.201122293253
[comparison of the maternal and neonatal effects of combined spinal-epidural block and spinal block for cesarean section].combined spinal-epidural block (cseb) has gained increasing interest as it combines the reliability of a spinal block (sb) and the flexibility of an epidural block in cesarean section. we investigated the maternal and fetal effect of cseb against sb in cesarean operation.201122290681
[capacities of diagnostic volumetric multislice spiral computed tomography in the diagnosis of gastric cancer].in the period 2009 to 2010, diagnostic multislice spiral computed tomography (msct) was carried out in 49 patients with gastric cancer. the efficiency of dynamic msct in detecting a tumor and determining its locoregional extent was evaluated. the results of dynamic msct were compared with those of postoperative histological examination. the possibility of detecting gastric cancer by dynamic msct was ascertained to depend on the depth of tumor invasion and to average 29, 71, 72, and 77% for t1, t ...201122288146
severe rhabdomyolysis and acute renal failure in an adolescent with hypothyroidism.hypothyroidism has been reported rarely as the cause of rhabdomyolysis in adults and children. we present here a non-compliant adolescent with a diagnosis of hypothyroidism who developed rhabdomyolysis and acute renal failure with no additional predisposing factor. a 13-year-old girl with a previous history of hypothyroidism due to thyroid hypoplasia presented with generalized myalgia, malaise, vomiting, and oliguria lasting for three days. neurological examination revealed bilateral marked weak ...201122272466
double-probe signal enhancing strategy for toxin aptasensing based on rolling circle amplification.on the basis of aptamer-based rolling circle amplification (rca) and magnetic beads (mbs), a highly sensitive electrochemical method was developed for the determination of ochratoxin a (ota). initially, an amino-modified capture dna was immobilized onto mbs for the following hybridization with an ota aptamer and a phosphate labeled padlock dna. in the presence of ota, the aptamer would dissociate from the bioconjugate, and the padlock dna would subsequently hybridize with the capture dna to form ...201122270050
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