Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| varicella vaccination in pediatric kidney and liver transplantation. | reports about efficacy and safety of live-virus attenuated vaccines in patients before and after transplantation are mainly based on small patient numbers, making general recommendations for this patient population difficult. children and adults as well as their close relatives and contact persons should be preferably immune to vzv before solid organ transplantation to avoid vzv-associated complications, thus making vzv vaccination necessary in susceptible individuals. the following literature r ... | 2010 | 20091941 |
| zoster vaccine (zostavax): a review of its use in preventing herpes zoster and postherpetic neuralgia in older adults. | individuals who have been infected with varicella zoster virus (vzv) are at risk for developing herpes zoster and this risk appears to be related to a decline in vzv-specific cell-mediated immunity (cmi). zostavax (zoster vaccine) is a one-dose, high-potency, live, attenuated vzv vaccine that boosts vzv-specific cmi and this is its presumed mechanism of action. zoster vaccine is registered in the eu for use in adults aged >or=50 years for the prevention of herpes zoster and herpes zoster-related ... | 2010 | 20104941 |
| etiology and clinico-epidemiological profile of acute viral encephalitis in children of western uttar pradesh, india. | to study the etiology of viral encephalitis (ve) in the children of western uttar pradesh, india and to assess the clinico-epidemiological profile of these children in relation to ve. | 2010 | 20106698 |
| characterization of the varicella-zoster virus orf50 gene, which encodes glycoprotein m. | the orf50 gene of the varicella-zoster virus (vzv) encodes glycoprotein m (gm), which is conserved among all herpesviruses and is important for the cell-to-cell spread of vzv. however, few analyses of orf50 gene expression or its posttranscriptional and translational modifications have been published. here we found that in vzv-infected cells, orf50 encoded four transcripts: a full-size transcript, which was translated into the gm, and three alternatively spliced transcripts, which were not trans ... | 2010 | 20106918 |
| comparison of the biological and biochemical activities of several members of the alphaherpesvirus icp0 family of proteins. | immediate-early protein icp0 of herpes simplex virus type 1 (hsv-1) is an e3 ubiquitin ligase of the ring finger class that is required for efficient lytic infection and reactivation from latency. other alphaherpesviruses also express icp0-related ring finger proteins, but these have limited homology outside the core ring domain. existing evidence indicates that icp0 family members have similar properties, but there has been no systematic comparison of the biochemical activities and biological f ... | 2010 | 20106921 |
| rapid automation of a cell-based assay using a modular approach: case study of a flow-based varicella zoster virus infectivity assay. | vaccine manufacturing requires constant analytical monitoring to ensure reliable quality and a consistent safety profile of the final product. concentration and bioactivity of active components of the vaccine are key attributes routinely evaluated throughout the manufacturing cycle and for product release and dosage. in the case of live attenuated virus vaccines, bioactivity is traditionally measured in vitro by infection of susceptible cells with the vaccine followed by quantification of virus ... | 2010 | 20117140 |
| medical image. varicella-zoster virus pneumonia. | 2010 | 21317967 | |
| atypical presentation of cytomegalovirus endotheliitis: a case report. | to describe an atypical case of cytomegalovirus (cmv) endotheliitis in a 74-year-old man who presented with chronic corneal edema without keratic precipitates (kps) and intraocular pressure (iop) elevation. | 2010 | 21034308 |
| fulminant hepatitis and death associated with disseminated varicella in an immunocompromised adult from the czech republic caused by a wild-type clade 4 varicella-zoster virus strain. | varicella zoster virus typically causes a benign disease in childhood called varicella (chickenpox) and can reactivate in adults as a dermatomally distributed, painful rash illness known as herpes zoster (hz). infection with vzv can however lead to severe complications in immunocompromised patients that can result in hospitalization and, occasionally, death. here we describe a patient, who acquired primary vzv infection during a 3-week-long treatment regimen with corticosteroids. the disease too ... | 2010 | 21056000 |
| monitoring prevalence of varicella-zoster virus clades in germany. | the global surveillance of varicella-zoster virus (vzv) clades is an important tool for investigation into viral evolution, host-virus interactions, role of immigration and travel for importation of viral strains as well as possible recombination events between wild- and vaccine-type vzv strains. in this prospective study, comprehensive data on the current distribution of vzv clades in germany were collected. vzv strains from 213 patients with varicella and 109 with zoster were genotyped using t ... | 2010 | 21072536 |
| regulation of the expression of the varicella-zoster virus open reading frame 66 gene. | the varicella-zoster virus (vzv) open reading frame (orf) 66 encodes a serine/threonine kinase that phosphorylates the major viral transactivator protein, immediate-early (ie) 62, preventing its nuclear importation. cytoplasmic sequestration of ie62 may alter viral gene transcription and could serve as a mechanism for maintaining vzv latency. we examined the regulation of expression of the orf66 gene by mapping the promoter region, which was localized to within 150 bases of the start codon. the ... | 2010 | 21074584 |
| herpes zoster in a 13-year-old healthy immunocompetent female patient. | 2010 | 21087834 | |
| persistence of varicella-zoster virus viraemia in patients with herpes zoster. | herpes zoster is caused by the reactivation of varicella-zoster virus from sensory neurons. the commonest complication following zoster is chronic pain termed post herpetic neuralgia. | 2010 | 21093356 |
| characterization of the nuclear import and export signals, and subcellular transport mechanism of varicella-zoster virus orf9. | varicella-zoster virus (vzv) open reading frame 9 (orf9) mrna is one of the most abundantly expressed messages during vzv infection. however, little is known concerning the function of orf9 protein. here, we found that transient expression of orf9 fused to enhanced yellow fluorescent protein (eyfp) in cos-7 cells showed a predominantly cytoplasmic localization in the absence of other viral proteins. by constructing a series of orf9 variants fused to eyfp, a bona fide bipartite nuclear localizati ... | 2010 | 21106804 |
| sequence analysis of the glycoprotein e gene of varicella-zoster virus strains of clades 1, 3 and 5. | eighty-six varicella-zoster virus (vzv) strains of clades 1, 3 and 5, isolated from varicella and zoster patients in germany, were analyzed by sequencing the glycoprotein e gene. four novel non-synonymous and 10 novel synonymous mutations were detected. of these, two synonymous (c513t, c885t) and two non-synonymous mutations (t485g, c524t) were located within the coding regions of e1 and c1. the profile of single-nucleotide polymorphisms was found to be significantly associated with the vzv clad ... | 2010 | 21116830 |
| granulomatous skin lesions complicating varicella infection in a patient with rothmund-thomson syndrome and immune deficiency: case report. | rothmund-thomson syndrome (rts)(omim 268400) is a rare autosomal recessive genodermatosis characterized by poikiloderma, small stature, skeletal and dental abnormalities, cataract and an increased risk of cancer. it is caused by mutations in recql4 at 8q24. immune deficiency is not described as a classical feature of the disease. here we report the appearance of granulomatous skin lesions complicating primary varicella zoster virus infection in a toddler with rothmund thomson syndrome and immune ... | 2010 | 21143835 |
| ramsay-hunt syndrome. | 2010 | 21185328 | |
| zoster ... "a lmost" ... sine herpete: diagnostic utility of real time-polymerase chain reaction. | zoster sine herpete is a particular form of varicella zoster virus (vzv) infection characterized by segmental pain and dysesthesia, without any cutaneous lesions ever becoming perceptible. this report describes the case of a female patient, presenting with intercostal pain associated with a single papulo-vesicular lesion localized within the same area. thanks to such a lesion, real time-polymerase chain reaction (pcr) analysis on vesicle fluid swab was possible, thus revealing a significant numb ... | 2010 | 21213602 |
| the efficacy of time-based short-course acyclovir therapy in treatment of post-herpetic pain. | various treatments have been used to manage post-herpetic neuralgia (phn). safe and effective therapies to prevent phn are needed. | 2010 | 21252455 |
| detection of igg-class antibodies to measles, mumps, rubella, and varicella-zoster virus using a multiplex bead immunoassay. | serologic testing for measles, mumps, rubella, and varicella (mmrv) igg is traditionally performed by immunofluorescence assay or enzyme immunoassay (eia). although sensitive and specific, these methods are labor intensive, time consuming, and require separate assays for each analyte. this study evaluated the performance of the mmrv igg athena multi-lyte assay using nonclinically characterized serum specimens submitted to our laboratory for routine mmrv igg testing. mumps (n = 492) or rubella (n ... | 2010 | 20638602 |
| the varicella-zoster virus ie4 protein: a conserved member of the herpesviral mrna export factors family and a potential alternative target in antiherpetic therapies. | during a viral infection, in addition to cellular mrnas, amounts of viral mrnas have to be efficiently transported to the cytoplasm for translation. it is now established that herpesviruses encode a conserved gene family whose proteins act as viral mrna export factors that mediate nucleocytoplasmic transport of viral transcripts and eventually modulate through this mechanism the antiviral response. this conserved family of proteins contains the ie4 protein of the varicella-zoster virus (vzv). he ... | 2010 | 20650265 |
| recombinant varicella vaccines induce neutralizing antibodies and cellular immune responses to siv and reduce viral loads in immunized rhesus macaques. | the development of an effective aids vaccine remains one of the highest priorities in hiv research. the live, attenuated varicella-zoster virus (vzv) oka vaccine, safe and effective for prevention of chickenpox and zoster, also has potential as a recombinant vaccine against other pathogens, including human immunodeficiency virus (hiv). the simian varicella model, utilizing simian varicella virus (svv), offers an approach to evaluate recombinant varicella vaccine candidates. recombinant svv (rsvv ... | 2010 | 20654666 |
| unusual oral complications of herpes zoster infection: report of a case and review of literature. | a case of herpes zoster infection with unusual oral complications involving the mandibular division of the trigeminal nerve is presented. the post-herpetic complications of osteonecrosis, spontaneous exfoliation of teeth, and subsequent pathologic fracture of mandible in the absence of concurrent predisposing factors in a 65-year-old man are demonstrated. forty-one cases with osteonecrosis and spontaneous exfoliation of teeth previously presented in the literature are reviewed. this is the first ... | 2010 | 20692192 |
| seroprevalence of varicella-zoster virus in polish population. | a varicella zoster virus (vzv) is the first herpesvirus for which a vaccine was developed. since 1999, the varicella vaccine is licensed in poland and recommended for use in adults without history of a varicella infection, and in children and young adults with remission of acute leukemia. while serological data is essential to assess the appropriate vaccination programme, we conducted the first in poland serosurvey on a representative group of polish population aged 1-19. serum samples were sele ... | 2009 | 20120946 |
| [vaccination in paediatric oncohaematology]. | one of the most important elements in prophylaxis of infectious diseases of children, is vaccination. it is essential that vaccination should be used correctly and safely in children in immunosupression, including the patients suffering from haematological malignancies. oncological diseases as well as anticancer therapy disturb the functioning of the immunological system. particulary deep immunosupression is observed in patients who have undergone stem cell transplantation. for this reason most ... | 2009 | 20081279 |
| herpesviridae and novel inhibitors. | herpesviridae comprises a large family of double-stranded dna viruses that infect both animals and humans. eight herpesviruses are known to infect humans: herpes simplex virus type-1 and -2, varicella zoster virus, human cytomegalovirus, epstein-barr virus, human herpesvirus 6 type-a and -b, human herpesvirus type-7 and -8 or kaposi's sarcoma virus. despite the fact that the past two decades have been evolutionary in the development of antiviral agents, therapeutic choices are restricted by limi ... | 2009 | 20032535 |
| simian varicella virus in pigtailed macaques (macaca nemestrina): clinical, pathologic, and virologic features. | simian varicella virus (svv; cercopithecine herpesvirus 9) is a naturally occurring herpesvirus of nonhuman primates. here we present the clinical, pathologic, and virologic findings from 2 cases of svv in adult female pigtailed macaques (macaca nemestrina). the initial case presented with hyperthermia and a diffuse inguinal rash which spread centripetally, progressing to vesiculoulcerative dermatitis of the trunk, face, and extremities. at 96 h after presentation, the animal was anorexic and le ... | 2009 | 19887033 |
| viral infections of the central nervous system: a case-based review. | three patients with viral infections of the central nervous system (cns) were evaluated on an inpatient infectious diseases consultation service within a two-week period. these cases, caused by herpes simplex virus, varicella zoster virus and enterovirus, highlight the importance of viral pathogens in causing debilitating infections of the cns and provide examples of the utility of molecular diagnostics in evaluating patients with encephalitis and meningitis. the importance of antiviral therapy ... | 2009 | 19889944 |
| distribution of herpes simplex virus type 1 and varicella zoster virus in ganglia of the human head and neck. | the distribution of the neurotropic alphaherpesviruses-herpes simplex virus type 1 (hsv-1) and type 2 (hsv-2) and varicella zoster virus (vzv)-was determined in autonomic and sensory ganglia of the head and neck obtained from formalin-fixed human cadavers. hsv-1 and vzv dna were found in 18 of 58 and 16 of 58 trigeminal, 23 of 58 and 11 of 58 pterygopalatine, 25 of 60 and 14 of 60 ciliary, 25 of 48 and 11 of 48 geniculate, 15 of 50 and 8 of 50 otic, 14 of 47 and 4 of 47 submandibular, 18 of 58 a ... | 2009 | 19919304 |
| pseudorabies virus infection alters neuronal activity and connectivity in vitro. | alpha-herpesviruses, including human herpes simplex virus 1 & 2, varicella zoster virus and the swine pseudorabies virus (prv), infect the peripheral nervous system of their hosts. symptoms of infection often include itching, numbness, or pain indicative of altered neurological function. to determine if there is an in vitro electrophysiological correlate to these characteristic in vivo symptoms, we infected cultured rat sympathetic neurons with well-characterized strains of prv known to produce ... | 2009 | 19876391 |
| varicella endotheliitis: a case report. | to report a case of varicella endotheliitis. | 2009 | 19882562 |
| tracking epitope-specific antiviral cd4+ t cell responses to a live attenuated vaccine reveals ongoing functional responses. | there are few studies that have examined the frequencies of epitope-specific cd4(+) t cells following the use of a highly effective vaccine, yet such data would potentially be of value for the development of novel vaccination strategies. in this study we tracked human epitope-specific cd4(+) t cell responses over time after immunisation with a live attenuated varicella zoster virus vaccine by mhc class ii tetrameric complexes and functional assays. we show that the peptide-specific responses ref ... | 2009 | 19744587 |
| interferon-gamma release assay: a simple method for detection of varicella-zoster virus-specific cell-mediated immunity. | herpes zoster is closely related to decreased varicella-zoster virus (vzv)-specific cell-mediated immunity. we validated a new assay for measuring vzv-specific immunity. we cultured the whole blood of healthy subjects with live attenuated vzv vaccine. cultured supernatants were harvested at 24-h intervals and assayed for interferon-gamma (ifn-gamma) by an enzyme-linked immunosorbent assay (elisa). the 48-h culture was suitable for estimating ifn-gamma release. ifn-gamma production was stable aft ... | 2009 | 19818791 |
| varicella zoster virus-associated polyradiculoneuritis. | 2009 | 19841388 | |
| the incidence and clinical characteristics of herpes zoster among children and adolescents after implementation of varicella vaccination. | the varicella-zoster virus (vzv) vaccine strain may reactivate to cause herpes zoster. limited data suggest that the risk of herpes zoster in vaccinated children could be lower than in children with naturally acquired varicella. we examine incidence trends, risk and epidemiologic and clinical features of herpes zoster disease among children and adolescents by vaccination status. | 2009 | 19536039 |
| antiviral therapy in patients with hematologic malignancies, transplantation, and aplastic anemia. | advances in supportive care over the past two decades have decreased the morbidity and mortality attributed to opportunistic infections in immunocompromised patients, including those with hematologic malignancies, hematopoietic stem cell transplantation (hsct), and aplastic anemia. despite advances in antiviral therapy, opportunistic viral infections such as influenza, herpes simplex virus (hsv), varicella zoster virus (vzv), and cytomegalovirus (cmv) still cause significant morbidity and mortal ... | 2009 | 19549576 |
| a phase i-ii study of live attenuated varicella-zoster virus vaccine to boost immunity in human immunodeficiency virus-infected children with previous varicella. | herpes zoster, may be severe and recurrent in hiv-infected children. we determined the safety and immunogenicity of live attenuated varicella-zoster virus (vzv) vaccine in 46 hiv-infected children who had experienced varicella. there were no serious adverse events. two years after vaccination 82% of subjects remained vzv-antibody positive and 60% had vzv-specific cell-mediated immunity. no child developed herpes zoster. | 2009 | 19561431 |
| detection of opportunistic dna viral infections by multiplex pcr among hiv infected individuals receiving care at a tertiary care hospital in south india. | opportunistic viral infections cause increased morbidity and mortality among human immunodeficiency virus (hiv) infected individuals, especially those who are not on antiretroviral treatment. early diagnosis of these opportunistic viruses will be able to reduce the risk of disease progression with appropriate intervention. | 2009 | 19584500 |
| acute retinal necrosis: clinical features, early vitrectomy, and outcomes. | to determine the viral diagnosis and the outcome of eyes with acute retinal necrosis (arn) treated with intravenous acyclovir and oral prednisolone alone or combined with early vitrectomy and intravitreal acyclovir lavage. | 2009 | 19592111 |
| case 11-2009: a man with fever, headache, rash, and vomiting. | 2009 | 19605842 | |
| acute retinal necrosis: a case series with clinical features and treatment outcomes. | to determine clinical features, viral aetiology and treatment outcomes of eyes with acute retinal necrosis (arn). | 2009 | 19624343 |
| inhibitory activity of oxyresveratrol on wild-type and drug-resistant varicella-zoster virus replication in vitro. | the anti-herpes simplex virus (hsv) compound, oxyresveratrol, purified from a thai traditional medicinal plant of artocarpus lakoocha, was evaluated for its anti-varicella-zoster virus (vzv) activity. this compound exhibited ic(50) values (50%-inhibitory concentrations for virus plaque formation) of 12.82, 12.80, 12.99 and 12.82 microg/ml against wild type, thymidine kinase-deficient and two types of dna polymerase mutants with acyclovir-resistance, respectively. thus oxyresveratrol showed a bro ... | 2009 | 19635502 |
| nonparametric estimator of relative time with application to the acyclovir prevention trial. | relative hazard is a central measure of association in randomized clinical trials. relative time (rt) is a competing measure that is rarely used. | 2009 | 19667028 |
| atypical manifestation of progressive outer retinal necrosis in aids patient with cd4+ t-cell counts more than 100 cells/microl on highly active antiretroviral therapy. | typical progressive outer retinal necrosis (porn) is an acute ocular infectious disease in acquired immunodeficiency syndrome (aids) patients with extremely low cd4+ t-cell counts. it is a form of the varicella- zoster virus (vzv) infection. this destructive infection has an extremely rapid course that may lead to blindness in affected eyes within days or weeks. attempts at its treatment have had limited success. we describe the case of a bilateral porn in an aids patient with an initial cd4+ t- ... | 2009 | 19702067 |
| acute pancreatitis associated with varicella infection in an immunocompetent child. | acute pancreatitis associated with varicella-zoster infection is a rare event, particularly in immunocompetent children. we report on a case of acute pancreatitis in a 6-year old girl presenting with acute abdominal pain less than 72 hours after the onset of a typical vesicular rash. the diagnosis was confirmed through hyperamylasaemia, ultrasonographic findings of oedematous pancreatitis and acute seroconversion to varicella-zoster virus, after excluding more common causes of acute pancreatitis ... | 2009 | 19702601 |
| varicella-zoster virus-specific immune responses to herpes zoster in elderly participants in a trial of a clinically effective zoster vaccine. | the objectives of this study were to evaluate the association between varicella-zoster virus (vzv)-specific humoral and cell-mediated immunity (cmi) to herpes zoster (hz) and protection against hz morbidity and to compare immune responses to hz and zoster vaccine. | 2009 | 19712037 |
| the double-edged sword of statin immunomodulation. | statin drugs are widely prescribed to achieve aggressive low-density lipoprotein lowering in order to decrease cardiovascular disease. although some of the immunomodulatory effects of statins may stabilize atherosclerotic plaque, they may be harmful in certain segments of the population. recently, statins have been shown to increase the concentration of regulatory t cells (tregs), in vivo. there is evidence that this increases the risk of many cancers, particularly in the elderly. furthermore, a ... | 2009 | 18485499 |
| prevalence of human herpes virus types 1-7 in the semen of men attending an infertility clinic and correlation with semen parameters. | to determine the prevalence of herpes viruses in the semen of an asymptomatic male cohort with and without infertility problems and its association with altered semen parameters. | 2009 | 18565516 |
| structure-activity relationships for dipeptide prodrugs of acyclovir: implications for prodrug design. | a series of water-soluble dipeptide ester prodrugs of the antiviral acyclovir (acv) were evaluated for their chemical stability, cytotoxicity, and antiviral activity against several strains of herpes simplex-1 and -2, vaccinia, vesicular stomatitis, cytomegalovirus and varicella zoster viruses. acv dipeptide esters were very active against herpetic viruses, independently of the rate at which they liberate the parent drug. their minimum cytotoxic concentrations were above 100 microm and the resul ... | 2009 | 18848738 |
| human ocular-derived virus-specific cd4+ t cells control varicella zoster virus replication in human retinal pigment epithelial cells. | varicella zoster virus (vzv)-induced retinitis is characterized by the presence of virus-infected cells in the retinal layer and the ocular infiltration of vzv-specific t cells. herein, the susceptibility of human retinal pigment epithelial (rpe) cells to vzv infection and the ability of virus-specific cd4(+) t cells to control vzv infection in rpe cells in vitro is addressed. | 2009 | 18936136 |
| deletion of the first cysteine-rich region of the varicella-zoster virus glycoprotein e ectodomain abolishes the ge and gi interaction and differentially affects cell-cell spread and viral entry. | varicella-zoster virus (vzv) glycoprotein e (ge) is the most abundant glycoprotein in infected cells and, in contrast to those of other alphaherpesviruses, is essential for viral replication. the ge ectodomain contains a unique n-terminal region required for viral replication, cell-cell spread, and secondary envelopment; this region also binds to the insulin-degrading enzyme (ide), a proposed vzv receptor. to identify new functional domains of the ge ectodomain, the effect of mutagenesis of the ... | 2009 | 18945783 |
| determinants of non-compliance with herpes zoster vaccination in the community-dwelling elderly. | as part of a series of studies on vaccine acceptance, we assessed determinants of compliance of the community-dwelling elderly with herpes zoster (hz) vaccination in an existing influenza vaccination program. general practitioners (gps) sent out a questionnaire to 1778 patients aged > or =65 years, and offered them free hz vaccination simultaneously with the yearly influenza vaccination. in all, 690 patients (39%) were vaccinated against hz; 1349 patients (76%) accepted influenza vaccination. de ... | 2009 | 18996427 |
| [herpes zoster in old adults]. | the varicella-zoster virus is an exclusively human herpesvirus, responsible for chickenpox. its reactivation, after several decades, causes herpes zoster (shingles). herpes zoster produces a rash, classically metameric, that causes acute pain and complications to elderly patients. the last, most painful, and disabling of these is postherpetic neuralgia. this neuralgia is defined as a painful syndrome lasting for more than 30 days after eruption of the rash. today's systemic antiviral drugs can r ... | 2009 | 19028069 |
| bortezomib administered pre-auto-sct and as maintenance therapy post transplant for multiple myeloma: a single institution phase ii study. | the appropriate induction therapy before and the role of maintenance therapy after auto-sct for patients with multiple myeloma remain areas of active investigation. we conducted a study in 40 patients with bortezomib given sequentially pre-auto-sct and as maintenance therapy post auto-sct. pre-transplant bortezomib was administered for two cycles followed by high-dose melphalan 200 mg/m(2) with auto-sct of g-csf-mobilized pbmcs. post transplant bortezomib was administered weekly for 5 out of 6 w ... | 2009 | 19029964 |
| genome-wide reduction in transcriptomal profiles of varicella-zoster virus vaccine strains compared with parental oka strain using long oligonucleotide microarrays. | varicella-zoster virus (vzv) causes varicella as a primary infection following which it becomes latent in human ganglia and then reactivates to cause herpes zoster. vzv vaccines are used to prevent primary infection with varicella, and also to reduce the incidence of viral reactivation causing herpes zoster and post-herpetic neuralgia. to gain further insights into the molecular basis of their attenuated virulence, we used long oligonucleotide microarrays to determine the lytic transcriptomal pr ... | 2009 | 19037717 |
| the course and outcome of unilateral intracranial arteriopathy in 79 children with ischaemic stroke. | arteriopathies are the commonest cause of arterial ischaemic stroke (ais) in children. repeated vascular imaging in children with ais demonstrated the existence of a 'transient cerebral arteriopathy' (tca), characterized by lenticulostriate infarction due to non-progressive unilateral arterial disease affecting the supraclinoid internal carotid artery and its proximal branches. to further characterize the course of childhood arteriopathies, and to differentiate tca from progressive arterial dise ... | 2009 | 19039009 |
| fatal varicella in an immunocompromised adult associated with a european genotype e2 variant of varicella zoster virus. | varicella zoster virus (vzv) seronegative patients under immunosuppressive therapy are at risk for severe life-threatening varicella. a 25-year-old male patient presented with rash and hepatitis. he had been known to suffer from crohn's disease and received immunosuppressive treatment with azathioprine. the patient showed dyspnoea, and presented with a generalized rash with vesicular lesions typical for herpesvirus infections. he was started immediately on acyclovir therapy. varicella infection ... | 2009 | 19056312 |
| characterization of neutralizing epitopes of varicella-zoster virus glycoprotein h. | varicella-zoster virus (vzv) glycoprotein h (gh) is the major neutralization target of vzv, and its neutralizing epitope is conformational. ten neutralizing human monoclonal antibodies to gh were used to map the epitopes by immunohistochemical analysis and were categorized into seven epitope groups. the combinational neutralization efficacy of two epitope groups was not synergistic. each epitope was partially or completely resistant to concanavalin a blocking of the glycomoiety of gh, and their ... | 2009 | 19073736 |
| q: who should receive the shingles vaccine? | 2009 | 19122110 | |
| [varicella in icelandic children--epidemiology and complications]. | varicella is a common disease with possible consequences. the disease is usually contracted in childhood and persistent antibodies are produced. varicella vaccine is not widely used in iceland. the aim of the study was to investigate the epidemiology of varicella in icelandic children and it s complications. the results may prove important when deciding on varicella immunization in iceland. | 2009 | 19197109 |
| discovery of anti-varicella zoster virus activity of polyether antibiotic cp-44161. | in search for new anti-varicella zoster virus (vzv) compounds with new mechanism of action, we applied a dna hybridization assay (dot blot method) for screening. using this method, we screened microbial products and found the polyether compound cp-44161 from the culture broth of an actinomycete strain. cp-44161 was previously reported as an anticoccidal agent, but there has been no claim of its antiviral activities. cp-44161 showed strong anti-vzv activity against poka strain by plaque reduction ... | 2009 | 19198636 |
| the simian varicella virus uracil dna glycosylase and dutpase genes are expressed in vivo, but are non-essential for replication in cell culture. | neurotropic herpesviruses express viral deoxyuridine triphosphate nucleotidohydrolase (dutpase) and uracil dna glycosylase (udg) enzymes which may reduce uracil misincorporation into viral dna, particularly in neurons of infected ganglia. the simian varicella virus (svv) dutpase (orf 8) and udg (orf 59) share 37.7% and 53.9% amino acid identity, respectively, with varicella-zoster virus (vzv) homologs. infectious svv mutants defective in either dutpase (svv-dutpase(-)) or udg (svv-udg(-)) activi ... | 2009 | 19200445 |
| components of nuclear domain 10 bodies regulate varicella-zoster virus replication. | pml, sp100, and daxx are proteins that normally reside within nuclear domains 10 (nd10s). they associate with dna virus genomes and repress the very early stages of the dna virus replication cycle. virus-encoded proteins counteract this innate antiviral response. icp0, a herpes simplex virus (hsv) immediate-early protein, is necessary and sufficient to dissociate nd10s and target their two major components, pml and sp100, for proteasomal degradation. in this report, we show that orf61p, the vari ... | 2009 | 19211749 |
| 4-benzyloxy-gamma-sultone derivatives: discovery of a novel family of non-nucleoside inhibitors of human cytomegalovirus and varicella zoster virus. | we report the synthesis and antiviral activity of a new family of non-nucleoside antivirals, derived from the 4-keto-1,2-oxathiole-2,2-dioxide (beta-keto-gamma-sultone) heterocyclic system. several 4- and 5-substituted-5h-1,2-oxathiole-2,2-dioxide derivatives were found to have a selective inhibitory activity against human cytomegalovirus (hcmv) and varicella zoster virus (vzv) replication in vitro, being inactive against a variety of other dna and rna viruses. a structure-activity relationship ... | 2009 | 19226140 |
| detection of herpes viruses in children with acute appendicitis. | this study aimed to investigate the incidence of herpes simplex virus (hsv) types-1 and -2, varicella-zoster virus (vzv), cytomegalovirus (cmv), epstein-barr virus (ebv), human herpes virus 6 (hhv-6) and human herpes virus 7 (hhv-7) in childhood acute appendicitis. | 2009 | 19233720 |
| disseminated varicella with multiorgan failure in an immunocompetent adult. | a case of fulminant disseminated varicella is reported in a 28-year-old immunocompetent man. he developed hepatitis, severe pneumonia, rhabdomyolysis and disseminated intravascular coagulation, followed by encephalopathy and multiorgan failure despite acyclovir therapy. he spent a total of 3.5 months in intensive care and rehabilitation units. real-time pcr yielded a rapid diagnosis of varicella-zoster virus (vzv) infection and was used to monitor plasma viral load for 56 days. plasma viral load ... | 2009 | 19235868 |
| pharmacokinetics and safety of famciclovir in children with herpes simplex or varicella-zoster virus infection. | two multicenter, open-label, single-arm, two-phase studies evaluated single-dose pharmacokinetics and single- and multiple-dose safety of a pediatric oral famciclovir formulation (prodrug of penciclovir) in children aged 1 to 12 years with suspicion or evidence of herpes simplex virus (hsv) or varicella-zoster virus (vzv) infection. pooled pharmacokinetic data were generated after single doses in 51 participants (approximately 12.5 mg/kg of body weight [bw] for children weighing < 40 kg and 500 ... | 2009 | 19273678 |
| the varicella zoster virus vasculopathies: clinical, csf, imaging, and virologic features. | 2009 | 19289747 | |
| herpes zoster keratouveitis and inflammatory ocular hypertension 8 years after varicella vaccination. | more than 8 years after varicella vaccination, a healthy 16 year-old boy presented with keratouveitis, severe inflammatory glaucoma in his left eye, and hutchinson's sign. he was treated with systemic acyclovir, topical steroids, cycloplegics, and glaucoma medications for a full recovery two months after presentation. it is unclear whether the source of herpes zoster which reactivated in this patient represents wild type virus or his previous vaccine strain. herpes zoster ophthalmicus is very ra ... | 2009 | 19294571 |
| varicella-zoster virus infection induces autophagy in both cultured cells and human skin vesicles. | when grown in cultured cells, varicella-zoster virus (vzv) forms many aberrant light particles and produces low titers. various studies have explored the reasons for such a phenotype and have pointed to impaired expression of specific late genes and at lysosomal targeting of egressing virions as possible causes. in the studies presented here, we report that the autophagic degradation pathway was induced at late time points after vzv infection of cultured cells, as documented by immunoblot analys ... | 2009 | 19297471 |
| varicella zoster virus redux. | in may 2008, the advisory committee on immunization practices (acip) of the centers for disease control and prevention in the usa recommended the routine administration of a live-attenuated high-potency varicella zoster vaccine to all adults over 60 years of age without specific contraindications, for the prevention and attenuation of herpes zoster (hz). nevertheless, many physicians still consider this vaccine to be of marginal value. this is not a reasonable conclusion. this short article revi ... | 2009 | 19306605 |
| hemorrhagic pericarditis in a child with primary varicella infection (chickenpox). | chickenpox (varicella) representing the primary infection by varicella zoster virus is a common benign and self-limited infectious disease of childhood. although the disease can be associated with complications, they are generally mild and tend to occur in adults and immunocompromised children. severe and life-threatening complications are extremely rare, particularly those involving the cardiovascular system. we report a malnourished 5-year-old girl with chicken pox complicated by hemorrhagic p ... | 2009 | 19332925 |
| varicella zoster vaccines. | in the past, the varicella zoster virus affected virtually the entire population and had substantial morbidity and mortality associated with both primary varicella and herpes zoster reactivation. since the varicella vaccine was first approved in 1995, there has been a significant decline in incidence, morbidity, and mortality caused by primary varicella. breakthrough disease with the one-dose vaccine schedule led to the recommendation in 2006 that children receive a two-dose vaccine series. olde ... | 2009 | 19335725 |
| the clinical picture: multiple huge bullae after renal transplant. | 2009 | 19339637 | |
| serological detection of specific igg to varicella-zoster virus by novel elisa based on viral glycoprotein antigen. | the novel ridascreen varicella-zoster virus (vzv) igg enzyme immunoassay (eia) based on viral envelope glycoproteins was evaluated using the fluorescent antibody to membrane antigen test as a reference. for the detection of vzv immunity in latently infected persons, the sensitivity of the ridascreen assay was 94-100%. thus, the novel eia had comparable sensitivity as the serion enzyme-linked immunosorbent assay (elisa) classic vzv igg and higher sensitivity than the elisa enzygnost anti vzv/igg. ... | 2009 | 19350844 |
| induction of sialyl-lex expression by herpes simplex virus type 1 is dependent on viral immediate early rna-activated transcription of host fucosyltransferase genes. | we have previously shown that varicella-zoster virus (vzv) and cytomegalovirus (cmv) infection of diploid human fibroblasts (hel) results in neo-expression of lewis antigens sialyl lewis x (sle(x)) and lewis y (le(y)), respectively, after transcriptional activation of different combinations of dormant human fucosyltransferase genes (fut1, fut3, fut5, and fut6), whose gene products are responsible for the synthesis of le antigens. here, we show that herpes simplex virus type 1 (hsv-1) also induce ... | 2009 | 19369700 |
| [familial predisposition and microbial etiology in dilated cardiomyopathy]. | cardiomyopathies are an important and diverse group of heart muscle diseases in which the heart muscle itself is structurally or functionally abnormal and in which coronary artery disease, hypertension, valvular and congenital heart disease are absent or do not sufficiently explain the observed myocardial abnormality. this often results in severe heart failure accompanied by arrhythmias and/or sudden death. clinical and morphological diversity of cardiomyopathies can reflect the broad spectrum o ... | 2009 | 19370326 |
| vitreous penetration of orally administered famciclovir. | to determine the vitreous penetration of penciclovir (denavir; glaxosmithkline, philadelphia, pennsylvania, usa) after oral administration of the prodrug famciclovir (famvir; novartis pharmaceuticals corp, east hanover, new jersey, usa). | 2009 | 19375688 |
| varicella as a trigger of atypical haemolytic uraemic syndrome associated with complement dysfunction: two cases. | we report two cases of children who presented with haemolytic uraemic syndrome following varicella infection. one of them had a membrane cofactor protein mutation, and the other had anti-factor h antibodies. these observations show that infectious agents such as varicella-zoster virus may be the trigger of haemolytic uraemic syndrome in patients with complement dysregulation. | 2009 | 19376828 |
| a protein microarray immunoassay for the serological evaluation of the antibody response in vertically transmitted infections. | the detection of specific serum antibodies is mainly achieved by enzyme-linked immunosorbent assay (elisa). here, we describe the setting up of a microarray-based serological assay to screen for igg and igm against vertically transmitted pathogens (toxoplasma gondii, rubella virus, cytomegalovirus, herpes simplex virus types 1 and 2, varicella zoster virus, chlamydia trachomatis). the test, accommodated onto a restricted area of a microscope slide, consists of: (a) the immobilization of antigens ... | 2009 | 19415353 |
| evidence of vaccine protection among thai medical students and implications for occupational health. | in a cross-sectional study of thai medical students, we compared the seroprevalence of antibody to measles virus, rubella virus, varicella zoster virus, hepatitis a virus, and hepatitis b virus with self-reports of prior infection or vaccination. self-report predicted immunity to varicella zoster virus only. these data contribute to risk assessment and occupational health strategies in this resource-limited setting. | 2009 | 19419330 |
| comparison of the pseudorabies virus us9 protein with homologs from other veterinary and human alphaherpesviruses. | pseudorabies virus (prv) us9 is a small, tail-anchored (ta) membrane protein that is essential for axonal sorting of viral structural proteins and is highly conserved among other members of the alphaherpesvirus subfamily. we cloned the us9 homologs from two human pathogens, varicella-zoster virus (vzv) and herpes simplex virus type 1 (hsv-1), as well as two veterinary pathogens, equine herpesvirus type 1 (ehv-1) and bovine herpesvirus type 1 (bhv-1), and fused them to enhanced green fluorescent ... | 2009 | 19420087 |
| pure motor herpes zoster induced brachial plexopathy. | brachial plexus neuritis in the presence of herpes zoster infection is uncommon. motor involvement is probably due to the spreading of inflammation from the dorsal root ganglia to the ventral roots and may be more extensive than the affected dermatomes. we present a case of herpes zoster brachial plexopathy with pure motor involvement both clinically and electrophysiologically. | 2009 | 19434442 |
| varicella-zoster virus vasculopathy and central nervous system immune reconstitution inflammatory syndrome with human immunodeficiency virus infection treated with steroids. | immune reconstitution inflammatory syndrome (iris) is widely recognized and rarely involves the central nervous system (cns). patients with acquired immunodeficiency syndrome (aids) are at an increased risk for developing cns-iris upon initiation of highly active antiretroviral therapy (haart). this syndrome can be fatal and requires extreme vigilance in determining if a treatable underlying opportunistic infection exists. we report here a case of varicella-zoster virus (vzv) vasculopathy and cn ... | 2009 | 19444693 |
| infectious complications in patients receiving autologous cd34-selected hematopoietic stem cell transplantation for severe autoimmune diseases. | long-term analysis of infectious complication after high-dose immunosuppressive therapy with cd34-selected autologous hematopoietic stem cell transplantation for patients with severe autoimmune diseases (ad) was performed. theoretically, cd34 selection can reduce the risk of reinfusion of autoreactive lymphocytes. however, it is also associated with a significant reduction in t cells, natural killer cells, and monocytes, which in turn may compromise immune reconstitution, thereby increasing the ... | 2009 | 19453993 |
| should you get the shingles vaccine? if you're 60 or older, the official recommendations say yes. but pluses and minuses make for a complicated equation. | 2008 | 19058405 | |
| [purpura fulminans: a rare complication of chickenpox]. | a 3.5-year-old boy presented with purpura on the buttocks extending towards both legs. two weeks earlier, he had had chickenpox. because of the rapidly progressing purpura with clinical signs of hypovolaemic shock, he was treated with fresh frozen plasma, packed red blood cells, intravenous immunoglobulins, prednisolone, acyclovir and ceftriaxone. the purpura stopped spreading. in the next few days, the skin at the site of the purpura became necrotic and was excised, as was the subcutis and part ... | 2008 | 19055261 |
| differentiation of wild-type varicella-zoster strains from india and the oka vaccine strain using a vzv open reading frame - 62 based pcr-rflp technique. | since the introduction of varicella vaccination in india, surveillance of circulating vzv strains has gained significance. differentiating wild-type vzv strains from the oka vaccine strain can be achieved only by molecular genotyping methods. the development of pcr methods for vzv strain differentiation has been hampered by the fact that the vzv genome is highly conserved. we used vzv orf 62 pcr-rflp analysis to identify and differentiate wild-type vzv strains in india from the oka vaccine strai ... | 2008 | 19030732 |
| [modelling the impact of vaccination on the epidemiology of varicella zoster virus]. | the soon to come the availability of a combined mmr-varicella vaccine has re-stimulated the debate around universal infant vaccination against varicella. in france, the incidence of varicella is estimated at about 700,000 cases per year, with approximately 3500 hospitalisations and 15-25 deaths, the latter mainly occurring in those over 15years. vaccination would certainly decrease the overall incidence of the disease but concerns about vaccination leading to a shift in the average age at infect ... | 2008 | 18951741 |
| discordant varicella-zoster virus glycoprotein c expression and localization between cultured cells and human skin vesicles. | because of its very low titer, varicella-zoster virus (vzv) infectivity is usually transferred by passage of trypsin dispersed infected cells. previously, we observed that gc biosynthesis was markedly delayed in monolayers inoculated with cell free virus. in this report, we investigated the kinetics of gc expression in more detail and included studies of monolayers inoculated with trypsin dispersed infected cells, the more traditional method of vzv infection. extensive imaging analyses disclosed ... | 2008 | 18954885 |
| vaccination and screening of medical students: results of a student health initiative. | to evaluate the immune status and vaccination needs of first-year medical students in relation to bloodborne viruses and common vaccine-preventable diseases. | 2008 | 18976187 |
| development of varicella after allogeneic cord blood transplantation in a varicella zoster virus seropositive patient. | 2008 | 18979611 | |
| [incorporation of varicella-zoster virus vaccination in childhood immunization schedules]. | varicella is a highly infectious disease caused by the varicella-zoster virus (vzv). usually chickenpox is a self-limiting and relatively mild disease of childhood, although it is frequently more severe with significant complications, and less often, is responsible for case fatalities. varicella disease is more severe and its complications are more frequent and severe amongst high risk groups (neonates, pregnant women and immunocompromised patients). after the initial infection, the vzv remains ... | 2008 | 18935757 |
| varicella-zoster virus open reading frame 66 protein kinase is required for efficient viral growth in primary human corneal stromal fibroblast cells. | varicella-zoster virus (vzv) open reading frame 66 (orf66) encodes a serine/threonine protein kinase that is not required for vzv growth in most cell types but is needed for efficient growth in t cells. the orf66 kinase affects nuclear import and virion packaging of ie62, the major regulatory protein, and is known to regulate apoptosis in t cells. here, we further examined the importance of orf66 using vzv recombinants expressing green fluorescent protein (gfp)-tagged functional and kinase-negat ... | 2008 | 18495764 |
| detection and quantitative analysis of human herpesvirus in pilocytic astrocytoma. | we investigated the hypothetical role of human herpesviruses (hhvs) in tumour formation of the cerebellum. thirty-five samples of pilocytic astrocytoma and 10 control samples of cerebellum from patients who died of unrelated diseases were examined. presence of the 8 known hhvs was first studied using specific real-time quantitative polymerase chain reaction (qpcr) targeting viral dna polymerase. hhv's dna polymerase was found present in 20 samples (7 controls, 13 astrocytomas) and was absent in ... | 2008 | 18565499 |
| rapid, sensitive, and specific lateral-flow immunochromatographic point-of-care device for detection of herpes simplex virus type 2-specific immunoglobulin g antibodies in serum and whole blood. | herpes simplex virus type 2 (hsv-2) is a common human pathogen that can cause a variety of clinical manifestations in humans. in order to provide near-patient results to allow for faster counseling and treatment, a rapid point-of-care test that is accurate and simple to use is desirable. here, we describe the development and evaluation of an hsv-2 immunoglobulin g (igg)-specific antibody lateral-flow immunochromatographic assay (lfia) based on colloidal gold nanoparticles. a total of 359 serum s ... | 2008 | 18003814 |
| unilateral associated laryngeal paralysis due to varicella-zoster virus: virus antibody testing and videofluoroscopic findings. | the relationship between varicella-zoster virus and idiopathic associated laryngeal paralysis was examined in five patients, using complement fixation or enzyme immunoassay testing. in all cases, significant changes in serum levels of varicella-zoster virus antibody were observed. videofluoroscopy was useful in assessing the severity of the dysphagia and in making an accurate diagnosis; both laryngeal elevation and weakness of pharyngeal wall contraction were also observed. in two cases in which ... | 2008 | 18005500 |
| the phosphorylation profile of protein kinase a substrates is modulated during varicella-zoster virus infection. | the camp-dependent protein kinase a (pka) is a key enzyme for many cellular mechanisms. in this study, we investigated the importance of this kinase for the replication of the alphaherpesvirus varicella-zoster virus (vzv). we report that the expression of the catalytic subunit of pka was strongly increased at the beginning of the viral cycle. the presence of a peptide inhibitor of pka had no consequence on viral replication in a melanoma cell line whereas in fibroblasts, it resulted in a drastic ... | 2008 | 18066594 |
| a double-blind, randomized, controlled, multicenter safety and immunogenicity study of a refrigerator-stable formulation of zostavax. | the vaccine zostavax has been shown to prevent herpes zoster (hz) and postherpetic neuralgia and is recommended for individuals > or =60 years of age. this study compared the safety and the immunogenicity of a refrigerator-stable formulation (zostavax refrigerated) with those of the current formulation (zostavax frozen) in subjects > or =50 years of age. subjects with a negative history for hz were randomized 1:1 to receive one dose of either formulation. enrollment was stratified 1:2 by age (50 ... | 2008 | 18077611 |
| herpes zoster infection after liver transplantation in patients receiving induction therapy with alemtuzumab. | the incidence of herpes zoster (hz) infection in liver transplant recipients prior to the use of induction therapy with monoclonal antibodies has been reported as being 1.2-18%. we studied the occurrence of hz in liver transplant recipients that received induction therapy with alemtuzumab (campath 1h). | 2008 | 18627401 |