Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| borrelia burgdorferi pathogenesis and the immune response. | borrelia burgdorferi is the tick-borne etiologic agent of lyme disease. the spirochete must negotiate numerous barriers in order to establish a disseminated infection in a mammalian host. these barriers include migration from the feeding tick midgut to the salivary glands, deposition in skin, manipulation or evasion of the localized host immune response, adhesion to and extravasation through an endothelial barrier, hematogenous dissemination, and establishment of infection in distal tissue sites ... | 2015 | 26593255 |
| ecology and epidemiology of lyme borreliosis. | lyme borreliosis is a zoonotic, tick-borne disease that infects humans worldwide. the disease is currently recognized as the most common vector-borne disease in europe and north america. disease is caused by several genospecies of the borrelia burgdorferi sensu lato complex. humans are at high risk of infection in regions where highly competent reservoirs are the primary hosts for the subadult stages of the tick, in contrast to regions where less competent or refractory animals feed ticks. human ... | 2015 | 26593254 |
| a study on the association between infectious burden and alzheimer's disease. | previous studies suggested that the overall burden of prior infections contributes to cardiovascular diseases and stroke. in the present study, the association between infectious burden (ib) and alzheimer's disease (ad) was examined. | 2015 | 24910016 |
| delayed onset of the jarisch-herxheimer reaction in doxycycline-treated disease: a case report and review of its histopathology and implications for pathogenesis. | the jarisch-herxheimer reaction (jhr) is a transient inflammatory syndrome triggered hours after the start of antibiotic treatment of spirochete infections, namely syphilis. clinically, jhr manifests as an abrupt onset of constitutional symptoms and exacerbation of cutaneous lesions that resolve without intervention. jhr's pathogenesis is unclear and it is histopathologically rarely reported. herein, the authors report a 47-year-old woman, with solitary erythema migrans and positive lyme disease ... | 2015 | 25033009 |
| suspected inflammatory cardiomyopathy. prevalence of borrelia burgdorferi in endomyocardial biopsies with positive serological evidence. | cardiac involvement in lyme disease, caused by the tick-borne spirochete borrelia burgdorferi, has been reported to occur in 0.3-4 % of infected patients in europe. cardiac manifestations may include conduction disturbances, and also myocarditis, pericarditis, and left ventricular dysfunction. we investigated the prevalence of b. burgdorferi dna in endomyocardial biopsies from patients with suspected inflammatory heart disease and positive serology for b. burgdorferi. | 2015 | 24938220 |
| characteristics of seroconversion and implications for diagnosis of post-treatment lyme disease syndrome: acute and convalescent serology among a prospective cohort of early lyme disease patients. | two-tier serology is often used to confirm a diagnosis of lyme disease. one hundred and four patients with physician diagnosed erythema migrans rashes had blood samples taken before and after 3 weeks of doxycycline treatment for early lyme disease. acute and convalescent serologies for borrelia burgdorferi were interpreted according to the 2-tier antibody testing criteria proposed by the centers for disease control and prevention. serostatus was compared across several clinical and demographic v ... | 2015 | 24924604 |
| assessing the contribution of songbirds to the movement of ticks and borrelia burgdorferi in the midwestern united states during fall migration. | the geographic distributions of ixodes scapularis (black-legged tick) and the bacterium borrelia burgdorferi (the causative agent of lyme disease) are expanding in the usa. to assess the role of migratory songbirds in the spread of this tick and pathogen, we captured passerines in central illinois during the fall of 2012. we compared forested sites in regions where i. scapularis populations were either previously or not yet established. ticks were removed from birds and blood samples were taken ... | 2015 | 25297819 |
| cutaneous borreliosis with a t-cell-rich infiltrate and simultaneous involvement by b-cell chronic lymphocytic leukemia with t(14;18)(q32;q21). | pseudolymphomatous infiltrates in borrelia infection of the skin most commonly manifest with dense b-cell infiltrates and plasma cells. cutaneous infiltrates of b-cell chronic lymphocytic leukemia (b-cll) may accumulate at sites of infection, including borrelia infection. we report an unusual constellation in a patient with synchronously diagnosed b-cll and borrelia infection of skin presenting with a dense dermal t-cell-rich infiltrate masking specific leukemic infiltrates of neoplastic b cells ... | 2015 | 25171429 |
| evaluation of two commercially available rapid diagnostic tests for lyme borreliosis. | the diagnosis of lyme disease is very complicated and a single diagnostic method cannot exclude infection. we assessed the performance of two commercially available borrelia burgdorferi rapid diagnostic tests (rdt) in comparison to multiple laboratory-based diagnostic assays using specimens with a gradually increasing probability of borrelia infection. based on 200 specimens, the analytical sensitivities for igg and igm were 18 and 23% for the lyme rdt and 24 and 32% for the borreliose complete ... | 2015 | 25073771 |
| [clinical and paraclinical features of syphilitic uveitis]. | syphilis, caused by treponema pallidum agent, results in polymorphic and non-specific ocular manifestations. early diagnosis and institution of individualized treatment play a large role in the prognosis. the increase in syphilis over the past several years requires the ophthalmologist to consider this diagnosis in the setting of any intraocular inflammatory involvement. | 2015 | 25637233 |
| disparities in reportable communicable disease incidence by census tract-level poverty, new york city, 2006-2013. | we described disparities in selected communicable disease incidence across area-based poverty levels in new york city, an area with more than 8 million residents and pronounced household income inequality. | 2015 | 26180961 |
| severe babesiosis and borrelia burgdorferi co-infection. | 2015 | 22685248 | |
| tick species (acari: ixodida) in antalya city, turkey: species diversity and seasonal activity. | ticks (acari: ixodida) are an important group of ectoparasites of vertebrates. most species are known vectors of diseases including lyme disease, q fever, and crimean-congo hemorrhagic fever. a 3-year research was conducted in antalya, turkey, to determine tick species composition, seasonal abundance, and spatial distribution. the study was carried out in five districts (aksu, dosemealtı, kepez, konyaaltı, and muratpasa) of antalya metropolitan municipality area in turkey, between may 2010 and m ... | 2015 | 25869959 |
| minocycline as a substitute for doxycycline in targeted scenarios: a systematic review. | doxycycline, a commonly prescribed tetracycline, remains on intermittent shortage. we systematically reviewed the literature to assess minocycline as an alternative to doxycycline in select conditions, given doxycycline's continued shortage. we identified 19 studies, 10 of which were published before 2000. thirteen of the studies were prospective, but only 1 of these studies was randomized. based on the available data, we found minocycline to be a reasonable substitute for doxycycline in the fol ... | 2015 | 26719847 |
| new borrelia species detected in ixodid ticks in oromia, ethiopia. | little is known about borrelia species transmitted by hard ticks in ethiopia. the present study was conducted from november 2011 through march 2014 to address the occurrence and molecular identity of these bacteria in ixodid ticks infesting domestic animals in oromia, ethiopia. a total of 767 ixodid ticks collected from domestic animals were screened for borrelia dna by quantitative (q) real-time pcr followed by standard pcr and sequencing to identify the species. overall, 3.8% (29/767) of the t ... | 2015 | 25843811 |
| arthropod-borne diseases: the camper's uninvited guests. | arthropod-borne diseases are a major problem whenever outdoor activities bring arthropods and people into contact. the arthropods discussed here include arachnids (ticks) and insects. most arthropod bites and stings are minor, with the notable exception being bee-sting anaphylaxis. ticks cause the most disease transmission. key hard tick vectors include black-legged (ixodes), dog (dermacentor), and lone star (amblyomma) ticks, which transmit lyme and various rickettsial diseases. insect repellen ... | 2015 | 26350321 |
| total protein concentration and diagnostic test results for gray wolf (canis lupus) serum using nobuto filter paper strips. | nobuto filter paper strips are widely used for storing blood-serum samples, but the recovery of proteins from these strips following rehydration is unknown. poor recovery of proteins could reduce the concentration of antibodies and antigens and reduce the sensitivity of diagnostic assays. we compared the protein concentration, and its association with test sensitivity, of eluted nobuto strip samples with paired sera. we collected and froze serum from five gray wolves (canis lupus) for 8 mo. when ... | 2015 | 25574804 |
| ngs population genetics analyses reveal divergent evolution of a lyme borreliosis agent in europe and asia. | borrelia bavariensis is a recently described agent of lyme disease within the b. burgdorferi sensu lato species complex and exhibits a strong capacity for human pathogenicity. b. bavariensis strains are widely distributed in eurasia spanning the distribution range of the tick vectors ixodes persulcatus and i. ricinus. it has been suggested that b. bavariensis forms two populations, one of which arose through vector adaptation and geographic expansion. we have performed phylogenetic and populatio ... | 2015 | 25766392 |
| poly-ticks, politics, and lyme disease. | 2015 | 15752526 | |
| third-degree heart block as initial presentation of lyme disease. | 2015 | 26717231 | |
| sero-epidemiological study of lyme disease among high-risk population groups in eastern slovakia. | iintroduction and objective. the aim of the presented cross-sectional sero-epidemiological study was to determine the current presence of antibodies against b. burgdorferi s.l. in the high-risk groups of the slovak population, and to identify potential risk factors to lb infections. | 2015 | 26706967 |
| leiomyosarcoma of the vagina: an exceedingly rare diagnosis. | background. primary leiomyosarcoma of the vagina is an exceedingly rare diagnosis. current estimates are that this tumor could at most represent a mere 0.062% of malignant neoplasms in the female genital tract, although in actuality it is likely far less common. case presentation. a 70-year-old female gravida 3 para 2 with new onset palpable vaginal mass and pink vaginal discharge is diagnosed with primary leiomyosarcoma of the vagina. chemotherapy is complicated by acute lyme disease, and the p ... | 2015 | 26783476 |
| an australian guideline on the diagnosis of overseas-acquired lyme disease/borreliosis. | 2015 | 26779732 | |
| human babesiosis: a general review with special reference to egypt. | babesiosis is a tick-borne malaria-like illness caused by species of the intra-erythrocytic protozoan babesia. humans are opportunistic hosts for babesia when bitten by nymph or adult ticks. currently, babesia infection is transmitted by various tick vectors in europe, asia, africa and the northwestern and northeastern united states. human babesiosis was first described in 1957 but is now known to have worldwide distribution. the increase in reported cases is likely due to increases in actual in ... | 2015 | 26939227 |
| incidence and patterns of extended-course antibiotic therapy in patients evaluated for lyme disease. | most patients with lyme disease (ld) can be treated effectively with 2-4 weeks of antibiotics. the infectious disease society of america guidelines do not currently recommend extended treatment even in patients with persistent symptoms. | 2015 | 26223992 |
| vesicular erythema migrans: an atypical and easily misdiagnosed form of lyme disease. | erythema migrans is the initial sign in the majority of patients infected with borrelia, the genus of spirochetes that causes lyme disease. early identification and treatment decrease the risk of progression to later stages of disease. although a "bull's eye" appearance owing to lesional clearing is considered classic for erythema migrans, this feature is surprisingly often lacking among patients in the united states. furthermore, cutaneous lyme disease can exhibit a wide range of morphologic va ... | 2015 | 26437159 |
| lyme disease presenting as a spontaneous knee effusion. | musculoskeletal complaints, which are frequently associated with lyme disease, often prompt patients to see a physician. in particular, transient episodes of spontaneous knee effusion are common early in the progression of lyme disease, and, if left untreated, 60% of patients diagnosed with the disease develop lyme arthritis. this disease is easily treated with antibiotics; therefore, inclusion of lyme disease in the differential diagnosis as a potential cause of a spontaneous knee effusion can ... | 2015 | 26416616 |
| cerebrospinal fluid cytology of lyme neuroborreliosis: a report of 3 cases with literature review. | lyme disease can affect the central nervous system causing a b-cell-predominant lymphocytic pleocytosis. since most reactions to infection in the cerebrospinal fluid (csf) are typically t-cell predominant, a b-cell-predominant lymphocytosis raises concern for lymphoma. we present 3 lyme neuroborreliosis cases in order to illustrate the challenging cytomorphological and immunophenotypic features of their csf specimens. three male patients who presented with central nervous system manifestations w ... | 2015 | 26343489 |
| study design questions regarding long-term assessment of health-related quality of life in patients with culture-confirmed early lyme disease. | 2015 | 26270689 | |
| undiagnosed lyme disease in adults with schizophrenia. | 2015 | 26255567 | |
| peroxidative metabolism of arachidonic acid in the course of lyme arthritis. | the objective of the study was measurement of serum arachidonic acid level as well as the product of its peroxidation - 8-isopgf2α, and the activity of phospholipase a2 and paf-acetylhydrolase that participate in releasing 8-isopgf2α from glycerol skeleton, and the potential designation of their role in the pathomechanism of lyme disease (ld). | 2015 | 26403109 |
| lyme disease: knowing good evidence to help inform practice. | 2015 | 25999231 | |
| using nation-wide health insurance claims data to augment lyme disease surveillance. | lyme disease (ld) is the most commonly reported tick-borne illness in north america. to improve ld surveillance, we explored claims data as an adjunct data source for monitoring trends in lyme disease incidence. | 2015 | 26393537 |
| transfusion-transmitted babesiosis during total hip arthroplasty. | babesiosis is a potentially life-threatening zoonotic disease that is endemic to the northeastern united states and increasing in prevalence worldwide. transmitted by the same ixodes tick responsible for lyme disease, the intraerythrocytic parasite babesia causes a wide range of clinical presentations--from asymptomatic carriage to a fulminant course with rapid deterioration. symptoms typically present 1 to 6 weeks after inoculation, with the gradual onset of fatigue, malaise, weakness, and inte ... | 2015 | 26375547 |
| [atypical form of lyme disease]. | 2015 | 26516401 | |
| lyme disease and juvenile idiopathic arthritis - a pediatric case report. | 2015 | 26498846 | |
| sixty seconds on . . . lyme disease. | 2015 | 26657946 | |
| seasonal activity, density, and collection efficiency of the blacklegged tick (ixodes scapularis) (acari: ixodidae) in mid-western pennsylvania. | although pennsylvania has recently reported the greatest number of lyme disease cases in the united states, with the largest increase for pa occurring in its western region, the population biology of the blacklegged tick (ixodes scapularis say) has not been adequately characterized in western pa. we studied the seasonal activity of host-seeking i. scapularis larvae, nymphs, and adults in mid-western pa over the course of a year, including a severe winter, and determined their absolute densities ... | 2015 | 26336271 |
| the skin as a target organ in multisystemic diseases ii. | progress in medical science has given a new reading to the claim that the skin could be a mirror of the pathological changes found in the internal organs. the concept that we previously promoted is furthered in this issue; namely that the greatest part of skin diseases are systemic ones. in this issue we focus on another group of diseases with systemic involvement and skin manifestations. we review such inflammatory conditions as lichen planus, autoinflammatory syndromes, and pyoderma gangrenosu ... | 2015 | 26321395 |
| isolated facial diplegia in guillain-barré syndrome: bifacial weakness with paresthesias. | bifacial weakness with paresthesias (bfp) is a subtype of guillain-barré syndrome defined by rapidly progressive bilateral facial weakness in the absence of other cranial neuropathies, ataxia, or limb weakness. many patients also complain of distal limb paresthesias and display diminished or absent deep tendon reflexes. bfp is a localized form of guillain-barré syndrome and is thought to be caused exclusively by demyelinating- rather than axonal-type neuropathy. patients with bfp do not display ... | 2015 | 26315943 |
| transient synovitis of the hip: which investigations are truly useful? | to assess the usefulness of several laboratory and radiological investigations for the limping child with suspected transient synovitis of the hip. | 2015 | 26295841 |
| [contribution of electronic health record in surveillance of notifiable diseases]. | in 2009 a system was introduced for the automatic import (ai) of cases with suspected notifiable diseases (nd) from electronic medical record (emr) to redalerta, an application for surveillance in andalusia. at present, the contribution of this system to classical active statement has not been determined enough. the main objective of this study is to evaluate the usefulness of ia in the province of granada, between 2009 and 2014. | 2015 | 26650475 |
| erythema migrans associated with partial horner's syndrome. | lyme disease is a tick-borne illness caused mainly by three species of spirochaete borrelia--b. burgdorferi, b. afzelii and b. garinii. it has three stages of presentation--early localised, early-disseminated and late lyme. erythema migrans is the most common manifestation of lyme disease, and is usually seen 7-14 days after the tick bite. patients seldom remember the tick bite. patients may often present with neurological manifestations indicating neuroborreliosis. these manifestations range fr ... | 2015 | 26643187 |
| lyme disease: time for a new approach? | 2015 | 26634936 | |
| appendix d: summary of evidence-based guideline for clinicians: treatment of nervous system lyme disease. | 2015 | 26633793 | |
| appendix c: practice parameter: diagnosis of patients with nervous system lyme borreliosis (lyme disease). | 2015 | 26633792 | |
| evaluation of a new multiparametric microspot array for serodiagnosis of lyme borreliosis. | laboratory diagnosis of lyme borreliosis follows a two-step algorithm, starting with a screening assay with maximum sensitivity followed by a confirmatory assay of positive results with respect to specificity. line immunoassays with single recombinant antigen lines are the established confirmatory test method, although result interpretation is not standardized. the present study evaluates suitability of the multiplex test seraspot anti-borrelia igg/igm (seraspot) as confirmatory test in serodiag ... | 2015 | 26731998 |
| lyme carditis in the fast lane: from alternating bundle branch block to asystole in 12 hours. | lyme borreliosis is a multisystem infectious disease with well-known cardiac involvement, including potential carditis as well as conduction abnormalities. we report a case of lyme disease in a previously healthy 24-year-old male presenting with alternating right- and left-bundle branch block, indicating infra-hisian atrioventricular (infra-his) block with an accelerated fascicular escape rhythm. inless than 12 hours, the conduction abnormalities progressed to asystole requiring the urgent place ... | 2015 | 26630701 |
| lyme disease. | lyme disease is among the most frequently diagnosed zoonotic tick-borne diseases worldwide. the number of human cases has been on the increase since the first recognition of its aetiological agent. lyme disease is caused by spirochete bacteria belonging to the genus borrelia, with b. burgdorferi sensu stricto (s.s.) found in the americas, and b. afzelii and b. garinii, in addition to b. burgdorferi s.s., in europe and asia. environmental factors, such as human encroachment onto habitats favourab ... | 2015 | 26601457 |
| lyme disease. recognising and treating erythema migrans. | lyme disease is a tick-borne bacterial infection caused by borrelia spirochetes. the first stage of infection involves a characteristic skin lesion, erythema migrans. erythema migrans is a ring-shaped skin lesion, centred on the bite, which expands outwards. it usually appears within two weeks after a bite from an infected tick. if left untreated, the infection sometimes extends or progresses over a period of months or years, leading to potentially severe neurological, articular, cutaneous and c ... | 2015 | 26594731 |
| tickborne borrelia infections: beyond just lyme disease. | 2015 | 26593264 | |
| alternatives to serologic testing for diagnosis of lyme disease. | although serologic testing remains the gold standard for laboratory diagnosis of lyme disease, the antibody response may take several weeks to increase greater than the limit of detection. because of this extended time frame, it is necessary to identify new diagnostic methods for earlier diagnosis and appropriate treatment of lyme disease. alternative diagnostic modalities, such as borrelia culture or nucleic acid amplification testing, may be beneficial in specific clinical scenarios. in early ... | 2015 | 26593259 |
| tick bite granuloma: recommendations for surgical treatment. | tick bite is known as a possible cause of some infectious diseases such as lyme disease, spotted fever and related illnesses. the reaction to a tick bite may persist for several months to several years and can sometimes cause histopathological granuloma. the long-term reaction to salivary extracts from the tick could be responsible for development of granuloma in our patient. we recommended complete resection as the only sure way to treat formed granuloma. | 2015 | 26190898 |
| recognition of and prompt treatment for tick-borne infections in children. | tick-borne infections create diagnostic challenges because they tend to present with nonspecific findings. because clinicians often fail to recognize tick-borne illnesses in early stages, therapy is frequently delayed or omitted. this is especially problematic for rickettsial infections (rocky mountain spotted fever, ehrlichiosis, and anaplasmosis), because the risk of long-term morbidity and mortality increases with delayed treatment. we emphasize the need for clinicians to maintain a high inde ... | 2015 | 26188606 |
| uveitis in adults: what do rheumatologists need to know? | rheumatologists may need to establish the etiological diagnosis and handle the therapeutic management of adults with uveitis. to date, no diagnostic strategy for uveitis has been validated by prospective studies. investigations are selected based on the clinical features and on the anatomic location of the ocular abnormalities. infections such as syphilis, lyme disease, tuberculosis, and whipple's disease may cause uveitis, with concomitant joint inflammation in a few cases. in patients with a k ... | 2015 | 26184541 |
| an examination of the demographic and environmental variables correlated with lyme disease emergence in virginia. | lyme disease is the united states' most significant vector-borne illness. virginia, on the southern edge of the disease's currently expanding range, has experienced an increase in lyme disease both spatially and temporally, with steadily increasing rates over the past decade and disease spread from the northern to the southwestern part of the state. this study used a geographic information system and a spatial poisson regression model to examine correlations between demographic and land cover va ... | 2015 | 26163019 |
| recent and rapid population growth and range expansion of the lyme disease tick vector, ixodes scapularis, in north america. | migration is a primary force of biological evolution that alters allele frequencies and introduces novel genetic variants into populations. recent migration has been proposed as the cause of the emergence of many infectious diseases, including those carried by blacklegged ticks in north america. populations of blacklegged ticks have established and flourished in areas of north america previously thought to be devoid of this species. the recent discovery of these populations of blacklegged ticks ... | 2015 | 26149959 |
| [isolated left abducens nerve palsy secondary to lyme disease in an 11-year-old boy]. | 2015 | 26138528 | |
| lyme disease comparators. | 2015 | 26129755 | |
| neuroborreliosis: the guillain-barré mimicker. | a 34-year-old woman presented to the medical admissions unit with progressive ascending weakness of her limbs and areflexia. diagnosis of guillain-barré syndrome was suspected and she was started on intravenous immunoglobulins. owing to a poor initial response, further exploratory history revealed travel to the new forest and a possible tick bite; subsequent investigations confirmed positive serology for antibodies against borrelia. the patient's weakness improved with intravenous ceftriaxone fo ... | 2015 | 26113585 |
| how far north are migrant birds transporting the tick ixodes scapularis in canada? insights from stable hydrogen isotope analyses of feathers. | lyme disease is emerging in canada because of northward range expansion of the tick vector ixodes scapularis. it is hypothesised that i. scapularis feeding on passerine birds migrating north in spring are important in founding new i. scapularis populations leading to northward range expansion. however, there are no studies on how far north i. scapularis may be carried, only inferences from passive tick surveillance. we used stable hydrogen isotope (δ(2)h) analysis of rectrices collected from nor ... | 2015 | 26100493 |
| lyme disease diagnosed by alternative methods: a phenotype similar to that of chronic fatigue syndrome. | a subset of patients reporting a diagnosis of lyme disease can be described as having alternatively diagnosed chronic lyme syndrome (adcls), in which diagnosis is based on laboratory results from a nonreference lyme specialty laboratory using in-house criteria. patients with adcls report symptoms similar to those reported by patients with chronic fatigue syndrome (cfs). | 2015 | 26082507 |
| efficacy and safety of pharmacological treatments for acute lyme neuroborreliosis - a systematic review. | our aim was to evaluate the available evidence for pharmacological treatment of acute lyme neuroborreliosis as a basis for evidence-based clinical recommendations in a systematic review. | 2015 | 26058321 |
| images in clinical medicine. disseminated lyme disease. | 2015 | 26017824 | |
| trazodone and omeprazole interaction causing frequent second-degree mobitz type 1 atrioventricular (av) block (wenckebach phenomenon) and syncope: a case report and literature review. | this case report highlights serious cardiovascular adverse effects with a conventional dose of trazodone as a result of its potential interaction with omeprazole. | 2015 | 26017199 |
| posttreatment lyme disease syndrome. | the prognosis following appropriate antibiotic treatment of early or late lyme disease is favorable but can be complicated by persistent symptoms of unknown cause termed posttreatment lyme disease syndrome (ptlds), characterized by fatigue, musculoskeletal pain, and cognitive complaints that persist for 6 months or longer after completion of antibiotic therapy. risk factors include delayed diagnosis, increased severity of symptoms, and presence of neurologic symptoms at time of initial treatment ... | 2015 | 25999226 |
| acute lyme neuroborreliosis with transient hemiparesis and aphasia. | nervous system involvement in lyme disease often mimics other conditions and thus represents a diagnostic challenge, especially in an emergency department setting. we report a case of a female teenager presenting with sudden-onset aphasia and transient right-sided faciobrachial hemiplegia, along with headache and agitation. ischemia, vasculitis, or another structural lesion was excluded by brain imaging. toxicologic evaluation results were negative. cerebral perfusion computed tomography and ele ... | 2015 | 25728308 |
| lyme disease in children. | the diagnosis and management of lyme disease in children is similar to that in adults with a few clinically relevant exceptions. the use of doxycycline as an initial empiric choice is to be avoided for children 8 years old and younger. children may present with insidious onset of elevated intracranial pressure during acute disseminated lyme disease; prompt diagnosis and treatment of this condition is important to prevent loss of vision. children who acquire lyme disease have an excellent prognos ... | 2015 | 25999224 |
| lyme carditis. | lyme disease is a common disease that uncommonly affects the heart. because of the rarity of this diagnosis and the frequent absence of other concurrent clinical manifestations of early lyme disease, consideration of lyme carditis demands a high level of suspicion when patients in endemic areas come to attention with cardiovascular symptoms and evidence of higher-order heart block. a majority of cases manifest as atrioventricular block. a minority of lyme carditis cases are associated with myope ... | 2015 | 25999222 |
| [protection against tick bites]. | there are numerous tick-borne infections, which include viral (tbe), parasitic (babesiosis) and bacterial diseases. lyme disease (lyme borreliosis) is the most common tick-borne disease in france. in temperate climates such as in france, ticks bite humans between march and october. prevention relies on adequate clothing and on repellents. the latter are reviewed in this work. repellents may be natural, made from eucalyptus, tomato and coconut, or synthetic, among which the most widely used is de ... | 2015 | 25624140 |
| lyme disease update for the general dermatologist. | lyme disease is an ixodes tick-borne illness that may arise from different species of the borrelia spirochete and may be propagated in various hosts. humans are considered dead-end hosts in this propagation cycle but may have a range of lyme disease characteristics as a result of borrelial infection. lyme disease has varied cutaneous manifestations, and the approach to diagnosis and treatment is based on the patient, the region, and suspected coinfection with another tick-borne illness. an under ... | 2015 | 25589049 |
| lyme disease in athletes. | lyme disease, a bacterial infection transmitted by ticks, is the most common vector-borne disease in the northern hemisphere. athletes who train or compete in wooded environments in endemic regions are at increased risk of contracting lyme disease. variability in clinical presentation, masquerading symptoms, and limitations in testing may lead to misdiagnosis. early diagnosis and treatment result in full recovery for most patients with lyme disease; however symptoms may persist for months to yea ... | 2015 | 25574885 |
| [lyme carditis]. | untreated lyme disease can affect the heart in up to 10% of patients. its clinical outcome and severity vary, ranging from asymptomatic minor conduction disturbances to potentially fatal arrhythmias and severe heart failure. a history of a tick bite or a typical previous skin lesion (erythema migrans) may be absent; clinicians should therefore keep a low threshold of suspicion when facing cardiac manifestations in a patient potentially exposed to the disease in endemic areas. we report the case ... | 2015 | 25924252 |
| tick-borne diseases of the usa: ten things clinicians should know. | this article highlights critical aspects of the epidemiology, diagnosis, and management of tick-borne infections in children. principles that apply broadly across the continental united states are emphasized, rather than details of each disease. tick-borne infections are often confused with other, more common childhood illnesses, in part because of their nonspecific initial clinical findings and because patients are usually unaware of their preceding tick exposures. this is a problem, because de ... | 2015 | 25917805 |
| supervised resistance exercise for patients with persistent symptoms of lyme disease. | the rapidly increasing incidence of lyme disease has become a serious public health problem. persistent symptoms of lyme disease occur in over 40% of the 300,000 new cases diagnosed annually in the united states and often include debilitating musculoskeletal pain, fatigue, and poor health-related quality of life. no clinical practice guidelines for lyme disease currently include resistance exercise partly because of concern over its safety and feasibility in this population. the goal of this pil ... | 2015 | 25899100 |
| diaphragm paralysis in lyme disease: late occurrence in the course of treatment and long-term recovery. | 2015 | 25897747 | |
| u.s. public's experience with ticks and tick-borne diseases: results from national healthstyles surveys. | surveillance data indicate that tick-borne diseases (tbds) are a substantial public health problem in the united states, yet information on the frequency of tick exposure and tbd awareness and prevention practices among the general population is limited. the objective of this study was to gain a more complete understanding of the u.s. public's experience with tbds using data from annual, nationally representative healthstyles surveys. there were 4728 respondents in 2009, 4050 in 2011, and 3503 i ... | 2015 | 25887156 |
| popliteal cyst with positive antinuclear antibodies as the presentation of lyme disease. | 2015 | 25876095 | |
| editorial commentary: what constitutes appropriate treatment of post-lyme disease symptoms and other pain and fatigue syndromes? | 2015 | 25852123 | |
| imported lyme disease. | 2015 | 25786470 | |
| association of toll-like receptor 2 arg753gln and toll-like receptor 1 ile602ser single-nucleotide polymorphisms with leptospirosis in an argentine population. | toll-like receptor 2 (tlr2), a member of the toll-like receptor family, plays an important role in the recognition of and subsequent immune response activation against leptospirosis in humans. the genetic polymorphism in tlr2 of an arginine to glutamine substitution at residue 753 (arg753gln) has been associated with a negative influence on tlr2 function, which may, in turn, determine the innate host response to leptospira spp. this bacterium signals through tlr2/tlr1 heterodimers in human cells ... | 2015 | 25784560 |
| landscape risk factors for lyme disease in the eastern broadleaf forest province of the hudson river valley and the effect of explanatory data classification resolution. | this study assessed how landcover classification affects associations between landscape characteristics and lyme disease rate. landscape variables were derived from the national land cover database (nlcd), including native classes (e.g., deciduous forest, developed low intensity) and aggregate classes (e.g., forest, developed). percent of each landcover type, median income, and centroid coordinates were calculated by census tract. regression results from individual and aggregate variable models ... | 2015 | 25779905 |
| geographical and temporal correlations in the incidence of lyme disease, rmsf, ehrlichiosis, and coccidioidomycosis with search data. | 2015 | 25756797 | |
| treatment of menière's disease. | diagnosis of menière's disease is made with a characteristic patient history, including discrete episodes of vertigo lasting 20 min or longer, accompanied by sensorineural hearing loss, which is typically low frequency at first, aural fullness, and tinnitus. workup includes audiometry, a contrast enhanced mri of the internal auditory canals, and exclusion of other diseases that can produce similar symptoms, like otosyphilis, autoimmune inner ear disease, perilymphatic fistula, superior semicircu ... | 2015 | 25749846 |
| molecular and pharmacological characterization of the chelicerata pyrokinin receptor from the southern cattle tick, rhipicephalus (boophilus) microplus. | we identified the first pyrokinin receptor (rhimi-pkr) in chelicerata and analyzed structure-activity relationships of cognate ligand neuropeptides and their analogs. based on comparative and phylogenetic analyses, this receptor, which we cloned from larvae of the cattle tick rhipicephalus microplus (acari: ixodidae), is the ortholog of the insect pyrokinin (pk)/pheromone biosynthesis activating neuropeptide (pban)/diapause hormone (dh) neuropeptide family receptor. rhimi-pkr functional analyses ... | 2015 | 25747529 |
| provider knowledge, attitudes, and practices regarding lyme disease in arkansas. | lyme disease (ld), a vector-borne disease, causes illness for many individuals in the united states. all of the conditions for the promulgation of ld are present in one southern state in the united states; yet this state reports lower numbers of ld than adjacent states. the purpose of this study was to determine associations between this southern state's primary care providers' knowledge and attitudes regarding the diagnosis and reporting of ld. a quantitative, cross-sectional study was conducte ... | 2015 | 25187225 |
| delay differential systems for tick population dynamics. | ticks play a critical role as vectors in the transmission and spread of lyme disease, an emerging infectious disease which can cause severe illness in humans or animals. to understand the transmission dynamics of lyme disease and other tick-borne diseases, it is necessary to investigate the population dynamics of ticks. here, we formulate a system of delay differential equations which models the stage structure of the tick population. temperature can alter the length of time delays in each devel ... | 2015 | 25348048 |
| [why can it be difficult for clinicians to diagnose acute lyme disease? from physiopathology to diagnosis, via abductive reasoning and bayes theorem]. | the diagnosis of acute neuroborreliosis may be difficult if it's regarded as a "classical" infectious disease. through a clinical case, we illustrate the difficulties met and we suggest two ways of reflexion to assist in the diagnosis:--firstly, we explain how the comprehension of the behavior of the pathogen agent, which is similar to a parasitic behavior, can help to choose and interpret the results of additional tests;--secondly, we develop practically the clinical form of bayes's theorem to ... | 2015 | 25672014 |
| variability in results from negative binomial models for lyme disease measured at different spatial scales. | lyme disease has been the subject of many studies due to increasing incidence rates year after year and the severe complications that can arise in later stages of the disease. negative binomial models have been used to model lyme disease in the past with some success. however, there has been little focus on the reliability and consistency of these models when they are used to study lyme disease at multiple spatial scales. this study seeks to explore how sensitive/consistent negative binomial mod ... | 2015 | 25460658 |
| seeks, finds, threats: lyme disease! | lyme borreliosis is a disease commonly found in humans. here we report the case of a young, healthy girl presenting with symptomatic first- and second-degree atrioventricular blocks secondary to cardiac myocarditis. the disappearance of the conduction anomaly after antibiotic treatment confirmed lyme disease before the results from the serology. therefore, when a healthy, young person suddenly presents with an atrioventricular conduction block, physicians should consider a diagnosis of lyme dise ... | 2015 | 25167973 |
| continuing increase of tick bites and lyme disease between 1994 and 2009. | nationwide cross-sectional retrospective studies have shown a continuous increase in general practitioner (gp) consultations for tick bites and diagnoses of erythema migrans between 1994 and 2005 in the netherlands. in this paper, we report incidence estimates for gp consultations for tick bites and erythema migrans diagnoses in 2009, and we compare the observed increase in gp consultations to reports of tick bites in two retrospective cross-sectional surveys of the general population. | 2015 | 25448421 |
| evaluating the child with acute hip pain ("irritable hip") in a lyme endemic region. | to estimate the prevalence of lyme infection among children presenting with acute, nontraumatic hip pain in a lyme endemic region and to investigate predictors of lyme disease among children with suspected transient synovitis. | 2015 | 25444013 |
| neoplasms misdiagnosed as "chronic lyme disease". | 2015 | 25365479 | |
| [facial diplegia as the presenting feature of lyme disease]. | diagnosis of neuroborreliosis may be difficult. neuroborreliosis mainly results in lymphocytic meningitis and in meningoradiculitis (67-83% of cases). | 2015 | 25096446 |
| overview of pediatric peripheral facial nerve paralysis: analysis of 40 patients. | peripheral facial nerve paralysis in children might be an alarming sign of serious disease such as malignancy, systemic disease, congenital anomalies, trauma, infection, middle ear surgery, and hypertension. the cases of 40 consecutive children and adolescents who were diagnosed with peripheral facial nerve paralysis at baskent university adana hospital pediatrics and pediatric neurology unit between january 2010 and january 2013 were retrospectively evaluated. we determined that the most common ... | 2015 | 24810082 |
| a tale of two syndromes: lyme disease preceding postural orthostatic tachycardia syndrome. | the pathogenesis of postural orthostatic tachycardia syndrome (pots) is poorly understood. however, it has been suggested that altered immune activity or denervation of the autonomic system following illness may be an important trigger. patients infected with lyme disease have a small incidence of post-lyme disease syndrome that share similar characteristics to pots. we report a short series of two women who present with persistent symptoms of orthostatic intolerance consistent with pots after t ... | 2015 | 24830783 |
| lyme borreliosis in southern united kingdom and a case for a new syndrome, chronic arthropod-borne neuropathy. | this series of serologically confirmed lyme disease is the largest reported in the uk and represents 508 patients who presented to one hospital in the south of england between 1992 and 2012. the mean rate of borreliosis throughout this period was 9·8/100,000 population, much higher than the reported national rate of 1·7/100,000. the actual rate increased each year until 2009 when it levelled off. patients clinically presented with rash (71%), neurological symptoms (16%, of whom half had vii cran ... | 2015 | 24814098 |
| [lyme disease--an update]. | lyme disease is a multiorgan infectious disease caused by the spirochete of the borrelia type. it is the most common vector-borne disease. a steady increase in the number of cases is noticed in poland. diagnosis and treatment of disease still cause many difficulties for clinicians. the aim of this study, based mainly on the recent literature, is to systematize knowledge on lyme disease, with particular attention to the clinical manifestations, diagnosis and therapy. | 2015 | 27012125 |
| acute exudative polymorphous vitelliform maculopathy in a patient with lyme disease. | acute exudative polymorphous vitelli-form maculopathy (aepvm) is a rare condition of unclear etiology that has been seen in association with respiratory and viral infections. it has also been reported as a paraneoplastic phenomenon in older individuals. the authors report the first case of aepvm associated with lyme disease with over 3.5 years of follow-up. multimodality serial imaging suggested the lesions began as multiple serous detachments followed by accumulation of photoreceptor outer segm ... | 2015 | 24044715 |
| [critical approach to antibiotic therapy in lyme disease]. | 2015 | 8560838 |