Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| surrogate end points for overall survival and local control in neoadjuvant rectal cancer trials: statistical evaluation based on the ffcd 9203 trial. | in resectable rectal cancer trials, pathological parameters are early preoperative treatment efficacy measures. their validation as surrogate end points for long-term clinical outcomes would allow to reduce trial duration. the aim was to evaluate potential surrogates for overall survival (os) and local control (lc) in preoperative t3/t4 rectal cancer trials. candidate variables included ypt and ypn stages, t downstaging, tumor regression grade (trg), and circumferential resection margin (crm) st ... | 2010 | 19759186 |
| recombinant human tsh and ablation of post-surgical thyroid remnants in differentiated thyroid cancer: the effect of pre-treatment with furosemide and furosemide plus lithium. | recombinant human tsh (rhtsh) can be used for post-surgical radioiodine (i-131) thyroid remnants ablation in differentiated thyroid cancer (dtc) patients after surgery. debate exists in literature about the optimal amount of i-131 that should be given for obtaining an effective ablation and about the role of iodine pool during treatment. therefore, the aim of the present study was to assess whether i-131 ablation during rhtsh stimulus can be improved by reducing the circulating iodine pool and b ... | 2010 | 19760415 |
| coordination of deiodinase and thyroid hormone receptor expression during the larval to juvenile transition in sea bream (sparus aurata, linnaeus). | to test the hypothesis that ths play an important role in the larval to juvenile transition in the marine teleost model, sea bream (sparus auratus), key elements of the thyroid axis were analysed during development. specific rt-pcr and taqman quantitative rt-pcr were established and used to measure sea bream iodothyronine deiodinases and thyroid hormone receptor (tr) genes, respectively. expression of deiodinases genes (d1 and d2) which encode enzymes producing t3, trs and t4 levels start to inc ... | 2010 | 19549532 |
| clinicopathologic significance of cd105-assessed microvessel density in glottic laryngeal squamous cell carcinoma. | intratumoral microvessel density (mvd) determined with the use of antibodies to endoglin (cd105) is considered to be an important prognostic marker in a variety of malignancies. the purpose of this study has been to analyze the clinicopathologic significance of cd105-assessed mvd in sccs primary localized in glottic region of larynx. | 2010 | 19553039 |
| radiosensitization of chemotherapy-refractory, locally advanced or locally recurrent breast cancer with trastuzumab: a phase ii trial. | trastuzumab (herceptin), an anti-human epidermal growth factor receptor 2 (her2) antibody, has been shown to be an effective radiosensitizer in preclinical studies. the present phase ii trial evaluated trastuzumab plus radiotherapy in patients with her2-positive, chemotherapy-refractory, locally advanced or locoregionally recurrent breast cancer. | 2010 | 19560883 |
| benchmarking circumferential resection margin (r1) resection rate for rectal cancer in the neoadjuvant era. | circumferential resection margin (crm) involvement (r1) is used to audit rectal cancer surgical quality. however, when downsizing chemoradiation (dcrt) is used, crm audits both dcrt and surgery, its use reflecting a high casemix of locally advanced tumours. we aimed to evaluate predictors of r1 and benchmark r1 rates in the dcrt era, and to assess the influence of failure of steps in the multidisciplinary team (mdt) process to crm involvement. | 2010 | 19508531 |
| dose-dependent acute effects of recombinant human tsh (rhtsh) on thyroid size and function: comparison of 0.1, 0.3 and 0.9 mg of rhtsh. | recombinant human tsh (rhtsh) is used to augment the effect of radioiodine therapy for nontoxic multinodular goitre. reports of acute thyroid swelling and hyperthyroidism warrant safety studies evaluating whether these side-effects are dose dependent. | 2010 | 19508679 |
| prospective phase ii study of neoadjuvant doxorubicin followed by cisplatin/docetaxel in locally advanced breast cancer. | the objective of this study is to evaluate the efficacy and safety profile of the doxorubicin followed by cisplatin/docetaxel as primary chemotherapy for patients with locally advanced breast cancer (labc). for this evaluation, 59 patients with labc (t2-t4, n0-n2, m0) received three cycles of doxorubicin, followed by three cycles of cisplatin/docetaxel and followed by definitive surgery and locoregional radiotherapy with or without tamoxifen. the primary end point was pathologic complete respons ... | 2010 | 19526202 |
| outcome after conservative surgery and breast irradiation in 5,717 patients with breast cancer: implications for supraclavicular nodal irradiation. | to evaluate the outcome and predictive factors of patients who underwent breast-conserving surgery and adjuvant radiotherapy to the whole breast only, without supraclavicular nodal irradiation. | 2010 | 19540052 |
| total androgen blockade versus a luteinizing hormone-releasing hormone agonist alone in men with high-risk prostate cancer treated with radiotherapy. | to assess whether short-course total androgen blockade vs. a luteinizing hormone-releasing hormone (lhrh) agonist alone affects the risk of prostate cancer-specific mortality (pcsm) in men with localized but high-risk disease treated with radiotherapy. | 2010 | 19540066 |
| intensity-modulated radiotherapy in the treatment of oropharyngeal cancer: clinical outcomes and patterns of failure. | to report outcomes, failures, and toxicities in patients treated with intensity-modulated radiotherapy (imrt) for squamous cell carcinoma of the oropharynx. | 2010 | 19540068 |
| late esophageal toxicity after radiation therapy for head and neck cancer. | the aim of this study was to determine the incidence of esophageal toxicity after radiation therapy for head and neck cancer. | 2010 | 19536858 |
| functional effects of short-term treatment with amiodarone on thyroid tissues of the rabbit. | the effect of short-term treatment with amiodarone on thyroid gland tissue was studied in a group of 26 new zealand albino rabbits. ten rabbits were left untreated and served as controls; the remaining animals were treated with 10 mg/kg/day amiodarone. the serum levels of serum triiodothyronine (t3), thyroxine (t4), and thyroid stimulating hormone (tsh) levels were measured at days 0 (baseline), 7, 30, and 45. the serum selenium levels were also measured, but only on days 0 and 45 of the experim ... | 2010 | 19547931 |
| identification of the etiologies of chronic urticaria in children: a prospective study of 94 patients. | the etiologies of chronic urticaria (cu) in childhood remains incompletely understood because of limited data in children. the objective of this study was to examine some of the possible etiologies of cu in children by focusing on the functional autoantibody to fcepsilonrialpha and ige, thyroid autoimmunity, urticarial vasculitis, parasitic infestation and food allergy. children 4-15 yr of age with cu were investigated for complete blood count, erythrocyte sedimentation rate (esr), antinuclear a ... | 2010 | 19555353 |
| prospective assessment of thoracic kyphosis in postmenopausal women with osteoporosis. | we attempt to assess quantitatively thoracic kyphosis and its influence on incident fractures and quality of life over three years in postmenopausal women with osteoporosis and the effect of strontium ranelate on thoracic kyphosis progression. this study was performed on women with postmenopausal osteoporosis from the spinal osteoporosis therapeutic intervention (soti) and treatment of peripheral osteoporosis (tropos) studies. vertebral fractures were assessed on lateral thoracic radiographs per ... | 2010 | 19594302 |
| clinical and dosimetric factors associated with a prolonged feeding tube requirement in patients treated with chemoradiotherapy (crt) for head and neck cancers. | patients treated with chemoradiotherapy (crt) for head and neck cancers often require feeding tubes (fts) due to toxicity. we sought to identify factors associated with a prolonged ft requirement. | 2010 | 19602566 |
| phase ii study of preoperative concurrent chemoradiation therapy with s-1 in patients with t4 oral squamous cell carcinoma. | to determine the feasibility and efficacy of preoperative concurrent chemoradiation therapy (ccrt) with s-1, an oral fluoropyrimidine derivative, in patients with t4 oral squamous cell carcinoma (scc). | 2010 | 19628343 |
| thyroid function and postpartum mood disturbances in greek women. | postpartum mood disturbances are very common with postpartum blues being as high as 44.5% among greek women. this study aimed to investigate whether thyroid function within the normal range affects the incidence of postpartum mood disturbances. | 2010 | 19632726 |
| low thyroglobulin concentrations after thyroidectomy increase the prognostic value of undetectable thyroglobulin levels on levo-thyroxine suppressive treatment in low-risk differentiated thyroid cancer. | recombinant human tsh-stimulated thyroglobulin (tg) levels (rhtsh-tg) are sufficient for early follow-up of low-risk differentiated thyroid cancer (dtc) patients after thyroidectomy and radioiodine (131i) remnant ablation (rai). serum tg levels at the time of remnant ablation (ablation-tg) is thought to be related with rhtsh-tg and may be predictive of recurrent disease. during long-term follow-up, tg levels on levo-t4 (l-t4) suppressive treatment (suppressive-tg) is sufficiently sensitive to av ... | 2010 | 19636213 |
| thyroid function and thyroid autoimmunity in childhood acute lymphoblastic leukemia off-therapy patients treated only with chemotherapy. | scanty data are available about the thyroid function in childhood acute lymphoblastic leukemia (all) off-therapy patients treated only with chemotherapy. we aimed to assess the prevalence of thyroid autoimmunity and thyroid dysfunction in such patients. | 2010 | 19636215 |
| whole-field simultaneous integrated-boost intensity-modulated radiotherapy for patients with nasopharyngeal carcinoma. | to retrospectively review the outcomes of our patients with newly diagnosed nondisseminated nasopharyngeal carcinoma treated with intensity-modulated radiotherapy using a whole-field simultaneous integrated-boost technique. | 2010 | 19646824 |
| a randomized placebo-controlled clinical trial of the effectiveness of thyroxine and triiodothyronine and short-term exposure to bright light in prevention of decrements in cognitive performance and mood during prolonged antarctic residence. | we examined the effects of a combined levothyroxine/liothyronine supplement and exposure to bright (10,000 lux) light in euthyroid men and women who spent the austral summer (n = 43) and/or winter (n = 42) in antarctica. | 2010 | 19650782 |
| improved endothelial function and lipid profile compensate for impaired hemostatic and inflammatory status in iatrogenic chronic subclinical hyperthyroidism of thyroid cancer patients on l-t4 therapy. | we aimed to compare the changes of endothelial function and haemostatic, inflammatory and metabolic parameters of short-term iatrogenic hypothyroidism to the characteristics of subclinical hyperthyroidism in patients with differentiated thyroid cancer. | 2010 | 19658059 |
| external beam radiotherapy plus 24-hour continuous infusion of gemcitabine in unresectable pancreatic carcinoma: long-term results of a phase ii study. | to evaluate the efficacy of gemcitabine-based chemoradiation (ct-rt) in treating patients (pts) affected by locally advanced pancreatic cancers (lapc). | 2010 | 19427747 |
| the clinical significance of neuroendocrine differentiation in t3-t4 node-negative colorectal cancer. | this study was conducted to determine the clinical significance of neuroendocrine differentiation in cases of t3-t4 node-negative colorectal cancer. eighty-nine patients diagnosed with t3-t4 node-negative colorectal cancer who underwent curative resection were enrolled. tumors expressing neuroendocrine markers were classified as either low expression (<or=2% cells staining positive for a neuroendocrine marker) or high expression (>2% cells staining positive for a neuroendocrine marker). immunohi ... | 2010 | 19372085 |
| updated results of bladder-sparing trimodality approach for invasive bladder cancer. | to update long-term results with selective organ preservation in invasive bladder cancer using aggressive transurethral resection of bladder tumor (turbt) and radiochemotherapy (rct) and to identify treatment factors that may predict overall survival (os). | 2010 | 19362865 |
| a prognostic index for predicting lymph node metastasis in minor salivary gland cancer. | large studies examining the clinical and pathological factors associated with nodal metastasis in minor salivary gland cancer are lacking in the literature. | 2010 | 19386433 |
| overt and subclinical thyroid dysfunction among indian pregnant women and its effect on maternal and fetal outcome. | thyroid disorders are among the common endocrine problems in pregnant women. it is now well established that not only overt, but subclinical thyroid dysfunction also has adverse effects on maternal and fetal outcome. there are few data from india about the prevalence of thyroid dysfunction in pregnancy. with this background, this study aims to find prevalence of thyroid dysfunction in pregnancy and its impact on obstetrical outcome in indian population. | 2010 | 19437026 |
| mage-a antigens in patients with primary oral squamous cell carcinoma. | mage-a antigens are only expressed on tumor cells. the aim of this study was to identify their expression in patients with oral squamous cell carcinoma (oscc). forty-seven patients with primary oscc was selected retrospectively. histo-pathological sections were stained immunohistochemically with mage-a antibody 57b. the results were evaluated regarding tumor size (t), lymph-node metastasis (n), blood vessel infiltration (v), lymph vessel infiltration (l), grading (g), and sex. mage-a antigens we ... | 2010 | 19488795 |
| preoperative t staging of gastric carcinoma obtained by mdct vessel probe reconstructions and correlations with histological findings. | this study aims to evaluate the diagnostic accuracy of 16-row multidetector ct (mdct) and vessel probe reconstructions in the t staging of gastric carcinoma. fifty-three patients (39 men, 14 women, mean age 57.5) with an endoscopic diagnosis of gastric adenocarcinoma underwent ct examination. a hypotonic drug was administered, and the gastric walls were distended by the ingestion of 400-600 ml of water. a biphasic technique with 40-s and 70-s delay was used after endovenous contrast material inj ... | 2010 | 19504100 |
| vertebral fracture assessment: impact of instrument and reader. | many osteoporotic vertebral fractures are not clinically recognized but increase fracture risk. we hypothesized that a newer generation densitometer increases the number of evaluable vertebrae and vertebral fractures detected. we also explored the impact of reader experience on vertebral fracture assessment (vfa) interpretation. | 2010 | 19506794 |
| modulation of key enzymes of glycolysis, gluconeogenesis, amino acid catabolism, and tca cycle of the tropical freshwater fish labeo rohita fed gelatinized and non-gelatinized starch diet. | a 60-day experiment was conducted to study the effect of dietary gelatinized (g) and non-gelatinized (ng) starch on the key metabolic enzymes of glycolysis (hexokinase, glucokinase, pyruvate kinase, and lactate dehydrogenase), gluconeogenesis (glucose-6 phosphatase and fructose-1,6 bisphosphatase), protein metabolism (aspartate amino transferase and alanine amino transferase), and tca cycle (malate dehydrogenase) in labeo rohita juveniles. in the analysis, 234 juveniles (2.53 +/- 0.04 g) were ra ... | 2010 | 19340598 |
| effect of a proprietary protein supplement on recovery indices following resistance exercise in strength/power athletes. | the effect of 42 g of protein ingested pre- and post-exercise on recovery from an acute resistance exercise session was examined in 15 male strength/power athletes who were randomly divided into a supplement (sup) or placebo (pl) group. subjects reported to the human performance laboratory (hpl) on four separate occasions (t1-t4). maximal strength [one repetition-maximum (1-rm)] testing was performed during t1. during t2 subjects performed four sets of ten repetitions at 80% of their 1-rm in the ... | 2010 | 19347247 |
| influence of t3 or t4 sympathicotomy for palmar hyperhidrosis. | this retrospective study aimed to compare the efficacy of video-assisted thoracoscopic sympathicotomy at the t3 or t4 level in the treatment of palmar hyperhidrosis. | 2010 | 19362283 |
| the combination of docetaxel and cisplatin plus fluorouracil as neoadjuvant chemotherapy in the treatment of t4 stage gastric cancer. | the prognosis of local advanced gastric carcinoma is very poor. we evaluated the impact on survival and the effects induced by the triple combination docetaxel-cisplatin-fluorouracil (dcf) as neoadjuvant chemotherapy in 24 t4 stage gastric tumor patients. they received 2-3 cycles dcf chemotherapy, followed by radical gastric resection. tumor downstaging detected by ct was obtained in 17 out of 24 patients. the overall 3-year survival rate was 68.2%. patients who received r0 resection (19/22) sho ... | 2010 | 19006661 |
| the role of thyroid hormone in the pathophysiology of heart failure: clinical evidence. | thyroid hormone (th) has a fundamental role in cardiovascular homeostasis in both physiological and pathological conditions, influencing cardiac contractility, heart rate (hr), diastolic function and systemic vascular resistance (svr) through genomic and non-genomic mediated effects. in heart failure (hf) the main alteration of thyroid function is referred to as "low-triiodothyronine (t3) syndrome" (lt3s) characterized by decreased total serum t3 and free t3 (ft3) with normal levels of thyroxine ... | 2010 | 19110971 |
| cardiac hypertrophy and thyroid hormone signaling. | thyroid hormone exerts a large number of influences on the cardiovascular system. increased thyroid hormone action increases the force and speed of systolic contraction and the speed of diastolic relaxation and these are largely beneficial effects. furthermore, thyroid hormone has marked electrophysiological effects increasing heart rate and the propensity for atrial fibrillation and these effects are largely mal-adaptive. in addition, thyroid hormone markedly increases cardiac angiogenesis and ... | 2010 | 19125327 |
| the children reference range of thyroid hormones in northern iran. | hypothyroidism is associated with mental and growth abnormality in children. the aim of this study was to determine the reference range of thyroid stimulating hormone (tsh). thyroxin (t4) and triodothyronine (t3) of children in northern iran. the sample population for this study consists of subjects of 4 age groups up to 21 years. the subjects were selected randomly from people referred to danesh medical diagnostic laboratory in gorgan northern iran. thyroid hormone level were investigated with ... | 2010 | 21313913 |
| hyaluronan based heparin free coated open and closed extracorporeal circuits for high risk coronary revascularization. | this prospective randomized study compares the inflammatory response and fibrinolytic activation of fully coated/uncoated and open/closed extracorporeal circuits (ecc) in high risk patients. over a 2-month period, 48 patients with euroscores 6 or greater undergoing coronary revascularization were prospectively randomized to one of the four perfusion protocols: group 1: closed and totally hyaluronan based heparin free coated (vision hfo-gbs-hf, gish biomedical, rancho santa margarita, ca) ecc wit ... | 2010 | 21313926 |
| polymorphisms in the microsomal epoxide hydrolase gene: role in lung cancer susceptibility and prognosis. | the aim of this study was to investigate the relationship between ephxi exon 3 tyr113his and exon 4 his139arg polymorphisms, predicted microsomal epoxide hydrolase (meh) activity, and lung cancer development. meh is a protective enzyme involved in oxidative defences against a number of environmental chemicals and pollutants, but it is also responsible for the xenobiotic activation of carcinogens. | 2010 | 21302624 |
| radical surgical treatment of the urinary bladder cancer in patients over the age of 60--our experiences. | the goal of the paper was the analysis of patients over the age of 60 suffering from the urinary bladder cancer that underwent radical surgical treatment of the urinary bladder and establishing urine derivation. in the 1972-2008 period 2405 patients with the urinary bladder cancer were treated, 296 (12.3%) of whom underwent radical surgical treatment. the average age was between 60 and 80 years--in 207 (70%) patients. in our patients there were 190 patients (91.6%) with transitional cell cancers ... | 2010 | 21302726 |
| [pleural metastases from bronchial carcinoma: is a cure possible?]. | the 2009 tnm classification of lung cancer reclassified patients with pleural invasion from stage iiib (t4) to stage iv (m+). however, the 2009 tnm separates patients with pleural metastases (m1a) from patients with others visceral metastases (m1b), the patients with stage m1a having the better prognosis. | 2010 | 21277479 |
| effect of hypo-and euthyroid status on serum cystatin c levels. | objective: the aim of this study was to investigate the effect of hypo- and euthyroid status on serum cystatin c (cysc) levels in children and to explore whether cysc can be used as a marker of the thyroid status.methods: twenty five patients with hypothyroidism (10m, 15f; mean age:8.7±4.9 years) and 21 healhty age-matched controls (9m, 12f; mean age: 9.7±5.0 years) were included in this study. serum thyrotropin (tsh), free thyroxine (ft4), serum cysc and creatinine levels were studied in patien ... | 2010 | 21274315 |
| hypothyroidism due to hepatic hemangioendothelioma: a case report. | although hemangioendothelioma (hhe) is a commonly encountered hepatic tumor during infancy, hhe-related hypothyroidism is rare. we present a patient who developed hhe-related hypothyroidism during the neonatal period and showed marked improvement in hypothyroidism by regression of hhe. a 28-day-old boy with tsh level of 77 miu/ml on neonatal screening and diagnosed as congenital hypothyroidism was started on l-thyroxine (l-t4) (11 μg/kg/day) therapy on the 21(th) day of life. on physical examina ... | 2010 | 21274327 |
| [clinical application of "funnel technique" in planting thoracic pedicle screws]. | to evaluate the safety and accuracy of "funnel technique" in planting thoracic pedicle screws. | 2010 | 21265197 |
| sensitivity to low-dose/low-let ionizing radiation in mammalian cells harboring mutations in succinate dehydrogenase subunit c is governed by mitochondria-derived reactive oxygen species. | it has been hypothesized that ionizing radiation-induced disruptions in mitochondrial o₂ metabolism lead to persistent heritable increases in steady-state levels of intracellular superoxide (o₂(•u+2212)) and hydrogen peroxide (h₂o₂) that contribute to the biological effects of radiation. hamster fibroblasts (b9 cells) expressing a mutation in the gene coding for the mitochondrial electron transport chain protein succinate dehydrogenase subunit c (sdhc) demonstrate increases in steady-state level ... | 2010 | 21268708 |
| bosentan treatment for raynauds phenomenon and skin fibrosis in patients with systemic sclerosis and pulmonary arterial hypertension: an open-label, observational, retrospective study. | raynaud?s phenomenon (rp) and cutaneous fibrosis are the distinctive manifestations of scleroderma, in which endothelin-1 plays a fundamental pathogenetic role. bosentan, an endothelin-1 receptor antagonist used for the treatment of pulmonary arterial hypertension, retards the beginning of new sclerodermic digital ulcers (du). this open-label, observational, retrospective study verified the effect of bosentan on rp and skin fibrosis in sclerodermic outpatients affected by pulmonary arterial hype ... | 2010 | 21244767 |
| metabolic disorders prevalence in sudden deafness. | the aim of the present study was to establish the frequency of metabolic disorders among patients with sudden deafness and to compare this frequency with data from population surveys. | 2010 | 21243289 |
| age-dependent variation in hormonal concentration and biochemical constituents in blood plasma of indian native fowl. | this experiment was to investigate the age-related changes in hormonal concentration and biochemical constituents of blood plasma in indian native desi fowl. one hundred and sixty two (54 from each breed, i.e., kadaknath (kn), aseel peela (ap), and white leghorn (wlh)) day-old female chicks were randomly divided into nine groups each of 18 chicks (3 groups × 3 replicates). wlh was taken in this study to compare the characteristics of indian native desi fowl. the highest level of estrogen hormone ... | 2010 | 21234314 |
| comparative analysis of the revised directive 2010/63/eu for the protection of laboratory animals with its predecessor 86/609/eec - a t4 report. | on 8th september 2010 the long process of revising the eu directive for the protection of laboratory animals was concluded. here a comparative evaluation of the new and old directive is provided. while its ultimate goal is to replace the use of animals, the new directive acknowledges that animals, including nonhuman primates, are still needed for scientific purposes today. importantly, animals have an intrinsic value, which must be respected. there are some major advances for animal welfare, man ... | 2010 | 21240470 |
| [the sentinel lymph node mapping in colon cancer]. | malignant tumors of the colon can metastases along the lymphatic system in a sequential way, which means that there will be a first node to be involved and then from this disease will pass to another node and so gradually. the sentinel lymph node is the first lymph node or group of nodes reached by metastasizing cancer cells from a tumor. | 2010 | 21232204 |
| analytic modeling of tidal effects in the relativistic inspiral of binary neutron stars. | to detect the gravitational-wave (gw) signal from binary neutron stars and extract information about the equation of state of matter at nuclear density, it is necessary to match the signal with a bank of accurate templates. we present the two longest (to date) general-relativistic simulations of equal-mass binary neutron stars with different compactnesses, c=0.12 and c=0.14, and compare them with a tidal extension of the effective-one-body (eob) model. the typical numerical phasing errors over t ... | 2010 | 21231639 |
| subclinical hypothyroidism in eastern nepal: a hospital based study. | subclinical hypothyroidism itself is associated with serious complications and also there is a known risk of subclinical hypothyroidism patients getting converted into overt disease. | 2010 | 21209542 |
| [early prediction of treatment response by serum crp levels in patients with advanced esophageal cancer who underwent definitive chemoradiotherapy]. | serum crp has been shown to be associated with the progression of esophageal cancer. the purpose of this study was to examine the relationship between treatment response and serum crp levels in time course during definitive chemoradiotherapy (crt) in terms of early prediction of crt response by serum crp. the subjects of this study were 36 patients with ct3/ct4 esophageal squamous cell carcinoma who underwent definitive crt in our hospital. serum crp levels during definitive crt (pretreatment, 1 ... | 2010 | 21224533 |
| [a case of unresectable advanced gastric cancer successfully treated with chemotherapy after gastrojejunostomy]. | we report a patient with unresectable advanced gastric cancer who was successfully treated with chemotherapy after gastrojejunostomy. a 64-year-old man was admitted to our hospital complaining of appetite loss and body weight loss. abdominal enhanced ct revealed a gastric wall thickening and swelling of lymph nodes in the lesser curvature. upper gastrointestinal endoscopy showed a gastric cancer in the antrum of the stomach. he underwent laparotomy, which revealed a t4 tumor invading the pancrea ... | 2010 | 21224615 |
| [thyroid dysfunction in primary care medicine]. | thyroid function tests include the measuring of the thyroid stimulating hormone (tsh) and free thyroxine (t4) in the case of abnormal tsh. these tests are frequently performed in primary care medicine since many clinical situations can be suggestive of dysthyroidism, as for example fatigue, depressive states or cardiac arthmia. in the case of subclinical thyroid dysfunction, the indications for treatment are controversial there being a lack of significant randomised studies. for primary care phy ... | 2010 | 21207724 |
| beyond translational research from t1 to t4: beyond “separate but equal” to integration (ti). | 2010 | 21207873 | |
| [distributions of primary nasopharyngeal carcinoma tumor and patterns of skull base erosion detected by magnetic resonance imaging]. | to evaluate the distributions of primary nasopharyngeal carcinoma (npc) and the patterns of skull base involvement in npc patients using magnetic resonance imaging (mri). | 2010 | 21223751 |
| serum free triiodothyronine (t3) to free thyroxine (t4) ratio in treated central hypothyroidism compared with primary hypothyroidism and euthyroidism. | the standard treatment of hypothyroidism (central and primary) consists of thyroxine (t4) administration alone. however, the normal thyroid gland produces a small proportion of triiodothyronine (t3) directly into the circulation. | 2010 | 21195684 |
| sentinel lymph node biopsy status is a key parameter to stratify the prognostic heterogeneity of malignant melanoma in high-risk tumors >4.0 mm. | the value of sentinel lymph node biopsy (slnb) as a useful strategy to assess the risk of future metastasis in high-risk melanomas (>4.0 mm) is controversially discussed. | 2010 | 21196701 |
| [operable colon cancer: initial strategy]. | individual screening of patients with personal or family history of colon cancer or polyps, or patients with an inflammatory condition of the digestive tract, combined with the generalization of mass screening using hemoccult, have modified the way colon cancer is diagnosed. the optimization of colon surgery, together with adjuvant chemotherapy, has improved the 5- and 10-year survival. the five-year survival rate is now comprised between 90 percent in patients with stage-i colon cancer, and 65- ... | 2010 | 21197740 |
| prognostic factors for elderly breast cancer patients in university malaya medical centre, malaysia. | information about elderly breast cancer patients' outcome is limited. this study aimed to evaluate the treatment outcomes in women aged 70 and above with specific analysis on prognostic clinicopathological features and treatment modalities. | 2010 | 21198264 |
| effect of levothyroxine treatment on in vitro fertilization and pregnancy outcome in infertile women with subclinical hypothyroidism undergoing in vitro fertilization/intracytoplasmic sperm injection. | to investigate whether levothyroxine (lt4) treatment has beneficial effects on ivf results and pregnancy outcome in infertile patients with subclinical hypothyroidism undergoing ivf/intracytoplasmic sperm injection (icsi). | 2010 | 21193190 |
| acanthamoeba t3, t4 and t5 in swimming-pool waters from southern brazil. | species of acanthamoeba, known to cause keratitis (ak) and granulomatous encephalitis in humans are frequently isolated from a variety of water sources. in this study, 13 acanthamoeba isolates from swimming pools were classified at the genotype level based on the sequence analysis of the acanthamoeba small-subunit rrna gene. nine of the 13 isolates were genotype t5, three were genotype t4, and one was t3. several genotypes have been reported worldwide as causative agents of ak, including genotyp ... | 2010 | 21195045 |
| spinal cord anaplastic oligodendroglioma with 1p deletion: report of a relapsing case treated with temozolomide. | primary spinal cord oligodendroglial tumor is very rare, and in only one patient with spinal cord oligodendroglioma has a deletion of chromosome 1p/19q been reported. we present the case of an 18-year-old girl, who had one-year lower back pain and one-month lower limb weakness. magnetic resonance images of the spinal cord showed an intramedullary mass from level t8 to t10, which was then radically removed. histology revealed an anaplastic oligodendroglioma. the patient was treated with radiother ... | 2010 | 21190059 |
| overexpression of cullin1 is associated with poor prognosis of patients with gastric cancer. | cullin1 (cul1) is a scaffold protein of the ubiquitin e3 ligase skp1/cullin1/rbx1/f-box protein complex, which ubiquitinates a broad range of proteins involved in cell-cycle progression, signal transduction, and transcription. to investigate the role of cullin1 in the development of gastric cancer, we examined the expression of cullin1 in primary gastric cancer tissues and analyzed the correlation between cullin1 expression and clinicopathologic variables and patients survival. we constructed a ... | 2010 | 21190721 |
| novel bacterial nad+-dependent dna ligase inhibitors with broad-spectrum activity and antibacterial efficacy in vivo. | dna ligases are indispensable enzymes playing a critical role in dna replication, recombination, and repair in all living organisms. bacterial nad+-dependent dna ligase (liga) was evaluated for its potential as a broad-spectrum antibacterial target. a novel class of substituted adenosine analogs was discovered by target-based high-throughput screening (hts), and these compounds were optimized to render them more effective and selective inhibitors of liga. the adenosine analogs inhibited the liga ... | 2010 | 21189350 |
| cetuximab in the treatment of head and neck cancer: preliminary results outside clinical trials. | the purpose of this study was to evaluate the clinical efficacy in our daily practice, outside clinical trials, of cetuximab plus radiotherapy in a majority of treatment-naive patients with locoregionally advanced head and neck squamous cell carcinomas. | 2010 | 21188107 |
| hypothyroidism in noninterferon treated-hcv infected individuals is associated with abnormalities in the regulation of th17 cells. | hcv-ag-specific th17 cells secrete il17, a cytokine involved in autoimmune diseases and regulated by il10 and tgf-b. 5-12% of patients with chronic hcv infection have hypothyroidism. we evaluated the role of these cytokines in this patients by determining serum concentration of tsh, t3, free t4, il2, il10, il12, il17, tgf-b, anti-tg, tpo, ccp, gbm, and cardiolipin antibodies in 87 chronically noninterferon treated hcv-infected patients. 20 patients (group a) had elevated tsh values (>5 μui/ml) w ... | 2010 | 21188205 |
| preoperative radiotherapy with capecitabine and mitomycin c in locally advanced rectal carcinoma. | purpose: to evaluate the efficacy and safety of preoperative radiotherapy with capecitabine and mitomycin c in patients with locally advanced rectal cancer. methods: a prospective, open-label, non-randomized, phase ii study was performed on 49 patients with locally advanced rectal cancer. preoperative radiotherapy was conducted on linear accelerators (15 or 18 mv) with a tumor dose of 45 gy in 25 fractions over 5 weeks, combined with mitomycin c 7 mg/m(2) on days 1 and 29 and oral capecitabine 8 ... | 2010 | 21188380 |
| vulnerability of healthy vertebrae in patients with and without previous vertebral fracture. | vertebral deformities are associated with a marked increase in morbidity, mortality, and burden in terms of sanitary expenditures. patients with vertebral fractures have a negative impact in their health, less quality of life, and loss of functional capacity and independence. the purpose of this study was to explore the vulnerability of healthy vertebrae in patients who have sustained already a compression fracture and in patients who do not have prevalent fractures in the thoracic spine; and to ... | 2010 | 21185414 |
| delayed colo-anal anastomosis is an alternative to prophylactic diverting stoma after total mesorectal excision for middle and low rectal carcinomas. | after total mesorectal excision (tme), a low colorectal or colo-anal anastomosis is usually performed. a prophylactic covering stoma is often used, especially for patients receiving neoadjuvant chemo-radiotherapy. however, morbidity is high, mainly due to anastomotic leakage. | 2010 | 21186091 |
| thyroid function in pregnancy. | advances in understanding the physiology of thyroid function in normal pregnancy have highlighted the importance of the consequences of abnormal function on obstetric outcome and foetal well-being. pubmed search was done using the terms thyroid and pregnancy. areas of agreement are the following: gestational normative reference ranges for thyroid function tests are required for proper interpretation of any abnormalities. measurement of thyroid-stimulating antibodies and antithyroid peroxidase an ... | 2010 | 21186204 |
| effects of acute normovolemic hemodilution on perioperative coagulation and fibrinolysis in elderly patients undergoing hepatic carcinectomy. | to observe the effects of acute normovolemic hemodilution (anh) on coagulation function and fibrinolysis in elderly patients undergoing hepatic carcinectomy. | 2010 | 21180275 |
| prognostic analysis in node-negative gastric cancer patients in china. | gastric cancer patients with negative nodes were considered to have better outcomes, however, some of them still suffered from disease recurrences or distant metastases after radical resection. a total of 1,020 gastric carcinoma patients receiving treatment in our center between 2003 and 2008 were selected for the analysis. all patients received gastrectomy and d2 lymphadenectomy. survival analysis was performed with cox regression model. the final study includes 222 patients. the overall 5-year ... | 2010 | 21181465 |
| prevalence of depression in patients affected by subclinical hypothyroidism. | the aim of this study was to estimate the prevalence of depressive symptoms in patients affected by subclinical hypothyroidism by means of hamilton rating scale for depression (ham-d) and montgomery-asberg depression rating scale (madrs); to assess which depressive symptoms are prevalent in our population, with references to the factorialization of ham-d by cleary and guy (1977); to verify whether levothyroxine replacement therapy alone can induce total remission of depressive symptoms. | 2010 | 21183887 |
| the effect of milrinone infusion on right ventricular function during coronary anastomosis and early outcomes in patients undergoing off-pump coronary artery bypass surgery. | during coronary anastomosis in off-pump coronary artery bypass surgery (opcab), hemodynamic alternations can be induced by impaired diastolic function of the right ventricle. this study was designed to examine the effect of milrinone on right ventricular function and early outcomes in patients undergoing opcab. | 2010 | 20740213 |
| age aspects of demography, pathology and survival assessment in colorectal cancer. | the aim of this study was to assess how age is related to differences in stage, tumour differentiation and treatment in colorectal cancer. | 2010 | 21187518 |
| [relationship between beta amyloid protein 1-40 and post-operative delirium after oral and maxillofacial surgery in elderly patients]. | to determine the incidence of post-operative delirium after oral and maxillofacial surgery under general anesthesia in elderly patients, and to examine its association with plasma concentrations of beta amyloid protein 1-40 (abeta1-40). | 2010 | 21179683 |
| persistence of bacteriophage t4 in a starved escherichia coli culture: evidence for the presence of phage subpopulations. | bacteriophage t4 is able to adjust its development to the growth parameters of the host cell. here, we present evidence for the production of two different subpopulations of phage particles, which differ in their ability to infect starved escherichia coli cells. the ability of phage t4 to produce a fraction of virions unable to infect starved cells is linked to the functions of genes ri and riii, as well as riia. this may represent the adaptation of phage t4 in order to persist in unfavourable e ... | 2010 | 21177930 |
| anchoring the type vi secretion system to the peptidoglycan: tssl, tagl, tagp... what else? | the recently identified bacterial type vi secretion system (t6ss) has rapidly become one of the most interesting areas of research in microbiology. in a relatively short period of time the relationship between the t6ss and the bacteriophage t4 tail and baseplate has been established. however, a number of questions concerning the t6ss remain the focus of a large number of researchers worldwide. key questions that need to be addressed include how this system assembles in the cell envelope and the ... | 2010 | 21178498 |
| postoperative radiotherapy in head and neck mucosal melanoma: a gettec study. | to report patterns of failure according to treatment modality, with an emphasis on the role of postoperative radiotherapy in patients with localized head and neck mucosal melanoma (hnmm) treated during a 28-year period in a multi-institutional setting. | 2010 | 21173371 |
| transoral robotic-assisted surgery for head and neck squamous cell carcinoma: one- and 2-year survival analysis. | to report 2-year survival outcomes for head and neck squamous cell carcinoma using transoral robotic-assisted resection. | 2010 | 21173375 |
| hormone replacement after thyroid and parathyroid surgery. | hypothyroidism and hypocalcemia are common after thyroid and parathyroid surgery. in this article, the authors provide clinically-oriented recommendations to help surgeons, general practitioners, internists, and endocrinologists give their affected patients adequate hormone replacement therapy. | 2010 | 21173898 |
| anticoccidial effects of coumestans from eclipta alba for sustainable control of eimeria tenella parasitosis in poultry production. | the aim of this study was to evaluate the anticoccidial efficacy of a product containing coumestans from eclipta alba. experimental conditions were set up as to reproduce the environment conditions for husbandry adopted in commercial broiler farms. broilers were raised in broiler chicken shed provided with feeders, drinkers, illumination and temperature control systems and floor covering to afford an adequate nourishing environment. male cobb broilers (240) were assigned to four experimental gro ... | 2010 | 21177038 |
| [recurrence of cancer of the paranasal sinuses after primary treatment--analysis of conditions and results of salvage treatment]. | the aim of this study: is to demonstrate epidemiological and clinical parameters of the group of patients with sinonasal malignancies and to analyze its impact on development of recurrences after primary surgical treatment conducted in head and neck surgery department of holly cross cancer center kielce during 7-years period 2001-2007. the retrospective analysis of the group of 42 patients with sinonasal malignancies was made, based on medical record and outpatient follow-up, considering: age, s ... | 2010 | 21171311 |
| [accelerated postoperative radiotherapy in patients with advanced larynx cancer]. | the aim of study was test efficacy of accelerated postoperative radiotherapy--concomitant boost in patients with advanced larynx cancer. | 2010 | 21171314 |
| anatomical study of position of the rib head for placing anterior vertebral body screws in a chinese population. | in this study, the variability of rib head position in a chinese population in terms of the spinal canal and vertebral body was analyzed using computed tomography (ct). images from transverse ct scan of the t4 to t12 vertebral bodies of 30 normal individuals were 3-dimensionally reconstructed, and analyzed for measurement of parameters that define the relative anatomic position of the rib head. we have found that the distance between the anterior border of the rib head and the posterior margin o ... | 2010 | 21162516 |
| [significance of subcarinal lymph node selective dissection in thoracic esophageal carcinoma]. | surgical resection remains the cornerstone of treatment for esophageal carcinoma. mediastinal lymphadenectomy including subcarinal nodes has always been considered to be a reasonable extent, because of close anatomical relationship between subcarinal nodes and tracheobronchial tree. metastatic involvement of subcarinal nodes alone is rare in esophageal carcinoma. in view of special anatomical features of subcarinal lymph nodes, it is worth exploring and discussing whether or not subcarinal lymph ... | 2010 | 21162932 |
| [the influence of lymph nodes detection on pathological staging in rectal cancer]. | to investigate the influence of lymph nodes detection on the pathological staging in rectal cancer specimens. | 2010 | 21163048 |
| research methodology: an innovative approach to a venerable course. | this paper outlines a number of innovations that we have recently implemented in the research methodology course at the university of michigan's school of public health. consistent with the goals of evidence-based medicine, evidence-based public health, intrinsic motivation, and phase 4 (t4) translational research, we have placed the emphasis on enhancing the students' desire to learn-and more specifically on their desire to learn rigorous methods for conducting useful research that delivers pra ... | 2010 | 21167007 |
| adolescents of the us national longitudinal lesbian family study: the impact of having a known or an unknown donor on the stability of psychological adjustment. | the current study is based on the us national longitudinal lesbian family study (nllfs), which was designed to document the development of the first generation of lesbian families with children conceived through donor insemination. data were collected in five waves, first at insemination or during pregnancy, and subsequently when the index children were 2, 5, 10 and 17 years old. the study is ongoing, with a 93% retention rate to date. the purpose of the current investigation was to assess chang ... | 2010 | 21169339 |
| sentinel node biopsy in colorectal cancer: must we believe it? | lymph node metastasis predicts survival and recurrence in colon cancer (cc), so decisions regarding adjuvant therapy are largely based on nodal status. chemotherapy is not a routine treatment for node-negative cc because its toxicity and expense exceed its limited benefit in patients without evidence of nodal involvement. the sentinel lymph node (sln) procedure is a selective sampling technique that can be used to ultrastage regional nodes. the real problem of sln biopsy in cc is the procedure s ... | 2010 | 21160827 |
| evaluation and follow-up of clinically euthyroid children with normal free t4 and suppressed tsh. | although subnormal tsh between 0.1-0.4 miu/l is fairly common and benign, suppression of tsh to < 0.1 miu/l with normal free t4 is less common and more worrisome. we have conducted a retrospective chart review of a collection of such cases and have summarized the features and outcome on follow up. | 2010 | 21158210 |
| quantitative pertechnetate thyroid scintigraphy and the ultrasonographic appearance of the thyroid gland in clinically normal horses. | we characterized the scintigraphic and sonographic appearance of the thyroid gland in clinically normal horses to establish the value of these modalities for assessment of the thyroid gland in this species. horses were divided into two age groups. one group consisted of eight horses between 3 and 10 years of age and the other of seven horses between 11 and 20 years of age. total t4 concentrations were within the laboratory reference interval in all horses. thyroid to salivary (t/s) ratio, percen ... | 2010 | 21158246 |
| effects of prochloraz or propylthiouracil on the cross-talk between the hpg, hpa, and hpt axes in zebrafish. | the objective of this study was to assess chemical-induced effects on cross-talk among the hypothalamic-pituitary-gonad (hpg), hypothalamic-pituitary-adrenal (hpa), and hypothalamic-pituitary-thyroid (hpt) axes of fish. adult female zebrafish were exposed to 300 μg/l prochloraz (pcz) or 100 mg/l propylthiouracil (ptu), and the transcriptional profiles of the hpg, hpa, and hpt axes were examined. exposure to pcz decreased plasma testosterone (t) and 17β-estradiol (e2) concentrations and affected ... | 2010 | 21158436 |
| assisting the diagnosis of graves' hyperthyroidism with pattern recognition methods and a set of three routine tests parameters, and their correlations with free t4 levels: extension to male patients. | in our previous paper, we proposed a novel screening method that aids the diagnosis of female patients with graves' hyperthyroidism via two types of neural networks and the use of routine test data. this method can be applied by non-specialists during physical checkups at a low cost and is expected to lead to rapid referrals for examination and treatment by thyroid specialists; i.e., to improve patients' qol. in this report, we investigate whether the screening method is also applicable to males ... | 2010 | 21159485 |
| a strategic approach for tongue reconstruction to achieve predictable and improved functional and aesthetic outcomes. | successful tongue reconstruction should restore swallowing, speech function, and cosmesis. the purpose of this prospective study was to evaluate the functional and aesthetic outcomes of tongue reconstruction using variable free flaps based on different tongue defects. | 2010 | 21124135 |
| specificity of interactions among the dna-packaging machine components of t4-related bacteriophages. | tailed bacteriophages use powerful molecular motors to package the viral genome into a preformed capsid. packaging at a rate of up to ∼2000 bp/s and generating a power density twice that of an automobile engine, the phage t4 motor is the fastest and most powerful reported to date. central to dna packaging are dynamic interactions among the packaging components, capsid (gp23), portal (gp20), motor (gp17, large "terminase"), and regulator (gp16, small terminase), leading to precise orchestration o ... | 2010 | 21127059 |
| hypothyroidism correlates with a better prognosis in metastatic renal cancer patients treated with sorafenib or sunitinib. | purpose: to investigate prognostic markers in patients with metastatic renal cell carcinoma (mrcc) undergoing treatment with the tyrosine kinase inhibitors (tkis) sorafenib (so) or sunitinib (su). patients and methods: eighty-three patients with mrcc, who were treated at our institution between 2006 and 2009, were evaluated prospectively. clinical and laboratory parameters were investigated, as well as, treatment-related adverse events. subclinical hypothyroidism was characterized by serum tsh a ... | 2010 | 21153827 |