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antibody response in rabbits to adenovirus type 12. 196313990410
inhibition by 5-iododeoxyuridine of the oncogenic effects of adenovirus type 12 in hamsters.subcutaneous tumors induced in newborn hamsters by type 12 adenovirus were suppressed when 0.5 mg of 5-iodo-2'-deoxyuridine (iudr) was given at the same subcutaneous site as the virus. although one injection of iudr given immediately after the virus was effective, additional injections on subsequent days reduced further the number of hamsters developing tumors. these effects of ludr are especially interesting since replication of infectious adenovirus 12 cannot be demonstrated in the hamsters at ...196314064445
effect of a possible oncogenic virus (adenovirus type 12) on lactate dehydrogenase in tissue culture. 196414074501
infection with adenovirus type 12. 196414074502
acute infectious lymphocytosis presenting as a pertussis-like illness: its association with adenovirus type 12. 196414074503
oncogenic effect of human adenovirus type 12, in mice.undifferentiated malignant tumors were induced at the site of injection of human adenovirus type 12 into newborn mice of the c(3)h(f)/ g(8). strain, but not of the dba(f), or a(f) strains. the tumors were grossly and histologically similar to those induced by this virus in hamsters, but appeared in a smaller percentage of injected mice than hamsters.196414075711
antibody to adenovirus type 12 among infants. 196414149186
adenovirus type 12 infection. clinical and laboratory studies. 196414151175
persistent infection of human cells (hela) with adenovirus type 12. 196414159694
virogenic hamster tumor cells: induction of virus synthesis.virogenic cell cultures of a hamster ependymoma originally produced by simian virus 40 were treated with proflavine, hydrogen peroxide, or mitomycin c. induction of virus synthesis was observed. similar experiments with hamster cells transformed by adenovirus type 12 or polyoma virus gave negative results196414163330
viruses and mammalian chromosomes; chromosome aberrations by human adenovirus type 12. 196414165598
in vitro transformation of hamster kidney cells by human adenovirus type 12. 196414166590
production of type-specific c antigen in virus-free hamster tumor cells induced by adenovirus type 12. 196414171456
characteristics of human adenovirus type 12 induced hamster tumor cells in tissue culture. 196414194601
immunofluorescent studies of adenovirus 12 tumors and of cells transformed or infected by adenoviruses.complement-fixing (cf) antibody-positive sera from hamsters bearing adenovirus type 12 (ad. 12)-induced tumors revealed specific immunofluorescent stainable antigens in essentially all ad. 12 hamster tumor cells. the antigens were primarily in the form of cytoplasmic flecks; less frequent staining was seen as nuclear flecks or homogeneous staining of nucleus and cytoplasm of a small proportion of cells. tumor cells did not stain with rabbit antisera to crude ad. 12 virus or a and c antigens. the ...196414212121
tumor immunity in hamsters infected with adenovirus type 12 or simian virus 40. 196414233501
hemagglutination and hemagglutination-inhibition with adenovirus type 12. 196514254549
antigenic variation among adenovirus type 12 strains. 196516562038
viruses and mammalian chromosomes. v. chromosome aberrations in tumors of syrian hamsters induced by adenovirus type 12. 19655840075
disappearance of tumorigenic activity from human adenovirus type 12. 19655840895
karyologic studies of normal cells and of adenovirus-type-12-induced tumor cells of the syrian hamster. 19655849591
electronmicroscopic examination of kb cell cultures infected with adenovirus type 12. 19655857325
the effect of calcium on cell lines derived from adenovirus type 12-induced hamster tumors. 19655890603
[morphologic structure of adenovirus type 12]. 19655894907
detection of adenovirus type 12 neoantigen (s) in a continuous human amnion cell line (fl) by immunofluorescence. 19655323559
electron microscopic studies on the tumor induced by adenovirus type 12. 19654223029
fine structure of negatively stained adenovirus type 12. 19654223616
effect of injection of adenovirus type 12 in adult hamsters. 19664226975
infection of human embryonic skin-muscle tissue culture cells with adenovirus type 12. 19664227144
interaction of a simian papovavirus and adenoviruses. i. induction of adenovirus tumor antigen during abortive infection of simian cells.feldman, lawrence a. (baylor university college of medicine, houston, tex.), janet s. butel, and fred rapp. interaction of a simian papovavirus and adenoviruses. i. induction of adenovirus tumor antigen during abortive infection of simian cells. j. bacteriol. 91:813-818. 1966.-adenovirus types 2, 7, and 12 undergo an abortive growth cycle in green monkey kidney cells; they induce the formation of adenovirus tumor antigen, but synthesis of adeno capsid antigen and infectious adenovirus was observ ...19664286827
virus-induced transplantation immunity to human adenovirus type 12 tumors of the hamster and mouse. 19664287123
potentiation of oncogenicity of adenovirus type 12 grown in african green monkey kidney cell cultures preinfected with sv40 virus. persistence of both t antigens in the tumors and evidence for possible hybridization. 19664287351
double infection of newborn syrian hamsters with simian virus 40 and human adenovirus 12. 19664287847
enhanced growth of human embryonic cells infected with adenovirus 12.fibroblast-like cells from human embryonic lung were infected with adenovirus type 12, and they survived as an established line, with the characteristics of "transformation" following considerable cellular killing. inclusion bodies disappeared and cells became resistant to reinfection with type 12 virus as they grew in thick multilayered strands, and giant and syncytial cells became commonplace. an induced new cell antigen demonstrable by complement-fixation and fluorescent-antibody studies pers ...19664288593
histogenesis of malignant neoplasm induced by adenovirus type 12. 19664289177
[oncogenic properties of human adenovirus type 12 for certain mammals]. 19664988196
immunofluorescence of human adenovirus type 12 in various cell types. 19664956667
viruses and mammalian chromosomes. vi. comparative karyologic and immunofluorescent studies on syrian hamster and human amnion cells infected with human adenovirus type 12. 19665327955
titration of adenovirus type 12 and type 18 in human embryonic kidney cell cultures. 19665296932
the nature of tumor antigen of adenovirus type 12 and its formation in cultured cells after infection. 19665296935
synthesis of virus deoxyribonucleic acid during abortive infection of simian cells by human adenoviruses.rapp, fred (baylor university college of medicine, houston, tex.), lawrence a. feldman, and manley mandel. synthesis of virus deoxyribonucleic acid during abortive infection of simian cells by human adenoviruses. j. bacteriol. 92:931-936. 1966.-inoculation of green monkey kidney cells (gmk) with adenovirus types 2 or 12, under conditions where neither infectious virus was synthesized, resulted in an increase in the uptake of h(3)-thymidine into deoxyribonucleic acid (dna). extraction of the dna ...19665927211
isolation and analysis of adenovirus 12 sub-units from adenovirus type 12-infected cells. 19665968787
an improved method of assay for human adenovirus type 12 (prototype strain) employing a clonal line of porcine kidney cells (brief report). 19665987105
[effects of adenovirus type 12 on hereditary mechanism of human cells]. 19666010155
specific transplantation antigens of mouse sarcomas induced by adenovirus type 12.a specific isograft resistance against three different mouse adeno 12 sarcomas was demonstrated in mice treated with four to eight doses of viable or x-ray-killed adeno 12 mouse tumors. whole-body x-ray irradiation with 350 r 24 hr previous to the test challenge did not abolish the resistance, indicating that it was due to a true anamnestic immune reaction. this was further proven by the finding that similar treatment with tumors of other origin did not induce any immunity, nor did the treatment ...19676020008
viruses and mammalian chromosomes. vii. the persistence of a chromosomal instability in regenerating, transplanted, and cultured neoplasms induced by human adenovirus type 12 in syrian hamsters. 19676021516
on the nature of transplantation immunity in the adenovirus tumor system.the existence of a virus-induced, virus-specific transplantation, antigen in adenovirus 12-induced cba mouse tumors was demonstrated. the antigen is virus-specific, but not related to structural virion or t antigens. it is a weak antigen, and required immunization with whole, infectious adenovirus 12 to produce considerable immunity. comparable immunity could not be achieved with homologous cellular or subcellular materials, but some indication of enhancement was produced with low tumor dose. im ...19676025323
in vitro transformation of cells of hamster brain by adenovirus type 12. 19676030579
electron microscopic localization of adenovirus type 12 antigens. 19676055784
effect of neonatal thymectomy on tumour induction by adenovirus type 12 in hamsters. 19676057758
transformation in vitro of the embryonal hamster brain cells by human adenovirus type 12. 19676061217
general characteristics of the cells transformed in vitro by human adenovirus type 12. 19676061218
alteration of growth rate and nutritional requirement of hamster brain cells transformed by adenovirus type 12 during their long-term cultivation. 19676064506
routine establishment of serial lines of hamster embryo cells transformed by adenovirus type 12. 19676067291
incubation period for tumor induction by adenovirus type 12. 19676081228
transformation of hamster cells in vitro by adenovirus. type 12. 19676081696
enzymatic changes in cell cultures infected with adenovirus type 12. 19675598986
induction of specific chromosomal aberrations by adenovirus type 12 in human embryonic kidney cells.nonrandom chromosomal breaks in chromosomes 1 and 17 were provoked in human embryonic kidney cells 24 hr after infection with adenovirus type 12. these chromosomal changes disappeared in persistently infected cultures. neutralization of the virus with type-specific antiviral serum prior to infection prevented the occurrence of chromosomal aberrations. no viral deoxyribonucleic acid (dna) synthesis, as determined by autoradiography, was seen in metaphases containing adenovirus type 12-induced chr ...19675621489
[symposium on the "cancer virus" 7. in vitro transformation by adenovirus type-12 and characteristics of the transformed cell]. 19675627339
adenovirus type 12-rat embryo transformation system.adenovirus type 12 (huie) inoculated into cultures of primary whole rat embryo produced foci of morphologically altered cells. the number and identification of these transformed areas was dependent upon the calcium concentration of the medium; more foci appeared in 0.1 mm than in 1.8 mm calcium. cell lines derived from these inoculated cultures did not yield infectious virus, and also were similar to cell lines derived from adenovirus type 12-induced tumors with respect to morphology, presence o ...19675630380
the detection of intracellular adenovirus type 12 antigens by indirect immunoferritin technique. 19675341938
neoplasms in hamsters induced by adenovirus type 12. 19676019572
wasting syndrome in thymectomized immature baboons (papio species) after infection with adenovirus type 12. 19674962026
pathological studies on the oncogenesis of adenovirus type 12 in hamsters. 19674870978
in vitro transformation by the adenovirus-sv40 hybrid viruses. ii. characteristics of the transformation of hamster cells by the adeno 2-, adeno 3-, and adeno 12-sv40 viruses.primary weanling hamster kidney cultures were transformed with the adeno 2-sv40, adeno 3-sv40, and adeno 12-sv40 hybrid viruses and with adenovirus type 12. the transformed cell lines which were established were characterized with respect to morphology, virus and antigen content, and chromosome aberrations. the adeno 2 and adeno 3-sv40 hybrid transformed cells had the morphology and t antigen content characteristic of sv40 transformations; cells transformed by the former hybrid had cytogenetic c ...19674289741
in vitro transformation by the adenovirus-sv40 hybrid viruses. 3. morphology of tumors induced with transformed cells.tumors induced with hamster kidney cells transformed by the adeno 2-, adeno 3-, adeno 7-, and adeno 12-sv40 hybrid viruses, and by adenovirus type 12, were examined histologically. the tumors induced with adeno 2-, adeno 3-, and adeno 7-sv40-transformed cells were similar to tumors induced with sv40-transformed hamster kidney cells but contained cells intermediate in morphology between sv40 and adenovirus tumor cells and occasionally contained nests of adenovirus-like cells. cells transformed by ...19674289742
infrequent c-f antibody response in mice with adenovirus type 12 tumors. 19674290454
adenovirus tumorigenesis: role of the viral genome in determining tumor morphology.adenovirus type 12 transforms the fibroblastic bhk21 (baby hamster kidney) cell line into rounded or cuboidal cells that give rise in hamsters to undifferentiated small cell sarcomas indistinguishable from those induced in newborn hamsters by inoculation of the virus itself. in contrast. cells from this line transformed by polyoma virus retain their fibroblastic morphology and induce fibrosarcomas in hamsters. this suggests that the morphology of tumors induced by the adenovirus-transformed cell ...19674290540
in vitro demonstration of humoral and cell-bound immunity against common specific transplantation atigen(s) of adenovirus 12-induced mouse and hamster tumors.a colony inhibition (ci) technique was used to demonstrate in vitro tumor-specific antigenicity common for neoplasms induced by the adenovirus type 12. immunization of mice against syngeneic mouse adeno 12 tumor cells evoked immunity demonstrable against other adeno 12 neoplasms of mice and of hamster as well. the immunity was detected as antibody activity in the sera of specifically immunized mice and as a similar activity of the lymph node cells of these animals. the finding in transplantation ...19674290563
increased tumour induction by adenovirus type 12 in thymectomized mice and mice treated with anti-lymphocyte serum. 19674293728
relationship between the subunits and "t" antigens of adenovirus type 12. 19674293730
chromosomal aberrations and cloning efficiency in adenovirus type 12-infected hamster cells.the fate of hamster cells, abortively infected with adenovirus type 12, has been studied by correlation of chromosomal aberrations with induction of t antigens and cloning efficiency. the incidence of chromosomal changes paralleled to some extent the t antigen formation, but was inversely related to the cloning efficiency of the cells. at an input multiplicity of 100, within 24 hr after infection, nearly all of the cells or metaphases revealed the presence of t antigens and chromosomal lesions, ...19684302188
persistence of the viral genome in adenovirus type 12-infected hamster cells.induction of t antigen by adenovirus type 12 was studied in growing and growth-inhibited cultures of the nil-2 line of syrian hamster cells. at a viral input multiplicity of 10, neoantigen was present in 100% of the cells by 24 hr. t antigen gradually disappeared in descendants of these cells so that 2 weeks after infection only 1% gave specific immunofluorescence. when cellular replication was prevented by addition of fluorodeoxyuridine, t antigen persisted in all cells for the 2-week period. u ...19684302189
oncogenicity of mixtures of adeno-associated virus and adenovirus type 12. 19684302692
human cell strains susceptible to focus formation by human adenovirus type 12. 19684303477
adenovirus transformation of hamster embryo cells.inoculation of hamster embryo cell cultures with human adenovirus type 12 (ad12) or simian adenovirus (sa7) resulted in the formation of foci of morphologically transformed cells within 12 days. the rapid appearance of well-defined foci was dependent upon the transfer of cells into new plates, with sufficient dilution after virus adsorption, and was independent of virus dose. dose-response studies showed linearity of focus formation with dilution of ad12 or sa7. results averaged from several exp ...19684316017
evidence for the igg nature of complement-fixing (cf) antibodies to adenovirus type 12 hamster tumor neoantigens. 19684169692
a search for a complement-fixing antibody in cancer patients against the tumor antigen of adenovirus type 12. 19684874890
changes accompanying long term tissue culture of an adenovirus type 12 tumour cell line. 19684883920
establishment of a malignant cell line derived from human adenovirus type 12-induced hamster tumor in tissue culture. 19684899948
association of adenovirus type 12 deoxyribonucleic acid with host cell chromosomes.preparations of purified (3)h-labeled adenovirus type 12 ((3)h-ad. 12) were analyzed for radioactive impurities by millipore filtration and ultracentrifugation. it was found that only about 1% of the isotope activity was separable from the virions. exposure of hamster cell lines to (3)h-ad. 12 resulted in nonlytic infections, and autoradiography indicated that viral deoxyribonucleic acid (dna), or parts thereof, became associated with host cell chromosomes. usually, the label was observed in the ...19684911853
chromosomal and autoradiographic studies of cells infected with herpes simplex virus.the induction of chromosomal aberrations by herpes simplex virus (hsv) and the interaction between viral deoxyribonucleic acid (dna) and chromosomes have been studied (i) by infection of the bhk-21 line of hamster kidney cells at multiplicities ranging from 0.5 to 100 followed by 1-hr pulses of (3)h-thymidine preceding preparation at varying intervals of metaphases and autoradiography, and (ii) by use of (3)h-thymidine-labeled hsv for infection, chromosomal, and autoradiographic analyses at inte ...19684302015
transformation of a hamster cell line by adenovirus type 12. 19685650922
the fate of the dna of adenovirus type 12 in baby hamster kidney cells. 19685248820
recovery of infectious virus from adenovirus type-12 tumor cells. 19685638605
reactivity of human sera with adenovirus type-12 hamster tumor antigens in the complement-fixation test. 19685638606
attempts to find human adenovirus type-12 tumor antigens in human tumors. 19685638607
autoradiographic studies on nuclei and chromosomes of cultured leukocytes after infection with tritium-labeled adenovirus type 12. 19685640821
transformation of rat kidney cells by adenovirus type 12. 19685654764
oncogenicity of mixtures of adeno-associated virus and adenovirus type 12. 19685659627
ultrastructural study of the replication of human adenovirus type 12 in cultured cells. 19685660942
virus and dna synthesis in x-irradiated human kidney cell cultures exposed to adenovirus type 12. 19685668103
adenovirus type 12 oncogenicity in newborn hamsters. the effect of pokeweed mitogen. 19685681657
application of passive hemagglutination methods for detection of antibody to viral antigen in hamsters bearing adenovirus type 12 tumors. 19685692103
separation of two components of adenovirus type 12 induced t-antigens with sephadex g-50. 19685703038
genetic studies with tumorigenic adenoviruses. i. isolation of cytocidal (cyt) mutants of adenovirus type 12. 19685723670
biochemical studies on adenovirus multiplication. 13. synthesis of virus-specific ribonucleic acid during infection with human adenovirus type 12.the transcription of virus-specific ribonucleic acid (rna) was studied in kb cells infected with adenovirus type 12 (strain huie). viral deoxyribonucleic acid (dna) synthesis began at 12 to 15 hr after infection, and virus maturation occurred between 20 and 50 hr after infection. the rate of incorporation of (3)h-uridine into rna per infected cell was stimulated, reaching a maximum of 1.6 times that of uninfected cells at 20 hr after infection. "early" viral messenger ribonucleic acid (mrna) con ...19685723708
human adenovirus type 12 as a "helper" for growth of h-1 virus. 19685742035
failure to detect incorporation of host cell dna into virions of adenovirus type 12. 19695784049
genetic studies with tumorigenic adenoviruses. ii. heterogeneity of cyt mutants of adenovirus type 12. 19695784054
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