Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| leproma of the mouse foot. | 1975 | 1097852 | |
| rifampin therapy of lepromatous leprosy. | patients with borderline-lepromatous (bl) or fully lepromatous (ll) leprosy were treated in the sanitarium for approximately 1 year with oral rifampin (600 mg daily) or with oral dapsone (100 mg daily). they were then treated as outpatients with intramuscular acedapsone (225 mg every 12 weeks) or oral dapsone (50 mg daily). they have now been followed for a total of 28 to 34 months. death of mycobacterium leprae during the initial 24 weeks was monitored by mouse inoculation with m. leprae from s ... | 1975 | 1098495 |
| acedapsone (dadds) treatment of leprosy patients in the karimui of papua new guinea: status at six years. | acedapsone (dadds), a repository sulfone given by injection five times a year, has been used since 1967 for the treatment of all leprosy patients in the karimui, an area of diffic-lt access. more than 460 patients have been treated, 336 beginning in november 1967 and continuing through the latest assessment 6 years later. the injections have been well received and they have been administered very regularly. clinical observations were begun before 1967, as a base-line of assessments was available ... | 1975 | 1098496 |
| acid mucopolysaccharide metabolism in leprosy. 3. hyaluronic acid mycobacterial growth enhancement, and growth suppression by saccharic acid and vitamin c as inhibitors of beta-glucuronidase. | a series of pilot studies are presented utilizing mouse and human infections with m. leprae and mouse infections with m. lepraemurium relating to the previously reported finding that hyaluronic acid seems to be a major nutrient substrate for these bacilli. the "feeding" of hyaluronic acid to the bacilli enhanced the growth of m. leprae in mouse abdominal walls and increased the morphologic index of m. lepraemurium infection. saccharic acid, an inhibitor of beta-glucuronidase previously reported ... | 1975 | 1099016 |
| effect of quinacrine, chloroquine and primaquine on the multiplication of mycobacterium leprae in mice. | quinacrine administered in 100 mg per kg body weight to mice had a bacteriostatic activity on m. leprae in the mouse, chloroquine at 15 mg per kg and primaquine at 0.25 mg per kg were without activity. these findings could point to the presence of a functioning direct oxidative pathway of glucose catabolism in m. leprae. | 1975 | 1099017 |
| a comparative evaluation of bacteriologic and morphologic indices of mycobacterium leprae in skin, lymph node, bone marrow, nerve and muscle. | this study elicits the comparative evaluation of the bacteriologic index (bi) and morphologic index (mi) of the skin, lymph node, bone marrow, nerve and muscle tissues of 15 untreated leprosy patients. the findings of comparable or even higher bi's and mi's in lymph nodes than skin are of considerable interest, especially the presence of a significant percentage of viable bacilli during reaction states when mi of skin and nerve tissue was found to be negative. evaluation of the bi's and mi's of ... | 1975 | 1099019 |
| the histopathology of lepromatous leprosy in the nose. | on the basis of clinical, histological and bacteriological assessments, 31 patients in central india were selected and classified as having active but early lepromatous leprosy and 4 patients as having early borderline leprosy. from the nose of each patient an average of 4 biopsies were taken from particular sites of the septum and turbinates either by punch biopsy or dissection with a scalpel. the nasal tissues from all the lepromatous patients contained many acid-fast bacilli; no bacilli or ab ... | 1975 | 1099180 |
| a simplification of the mouse foot-pad infection using mycobacterium leprae from skin scrapes. | 1975 | 1099371 | |
| field workers' forum. biopsies in leprosy. | 1975 | 1099373 | |
| letter: nasal mucosa as the portal exit of mycobacterium leprae. | 1975 | 1099374 | |
| cytochrome pigments in mycobacterium leprae isolated from armadillos (dasypus novemcinctus l.). | the bacilli were isolated from granulomata harvested from armadillos. cytochrome systems in whole cell suspensions as well as in cell-free extracts were examined spectrophotometrically. the intact cells contained cytochromes of the a+b3, b and c type which were found to be present mainly in the reduced form. the cytochrome systems in cell-free extracts of m. leprae were in the oxidized form but contained the same type of cytochromes as the intact bacteria. the presence of cytochromes was easily ... | 1975 | 1099400 |
| [microbiology of leprosy. is there an in-vitro cultivable phase of hansen's bacillus]. | 1975 | 1099992 | |
| rifampicin: the investigation of a bactericidal antileprosy drug. | 1975 | 1100951 | |
| the use of rifampicin in the treatment of leprosy. | 1975 | 1100952 | |
| the effect of a single dose of rifampicin on the infectivity of the nasal discharge in leprosy (preliminary communication). | 1975 | 1100954 | |
| clinical and bacteriological effects of rifampicin in combination with l73a in leprosy: observation for six months. | 1975 | 1100957 | |
| chemotherapeutic trials in patients with non-lepromatous leprosy. | 1975 | 1100965 | |
| viability of myco. leprae in the skin and bone marrow of patients with lepromatous leprosy while on dapsone or lamprene. | 1975 | 1100966 | |
| effect of mono treatment and combined treatment on the morphology of myco. lepare in the skin. | 1975 | 1100967 | |
| treatment of leprosy with clofazimine, rifampicin and bayrena. | 1975 | 1100968 | |
| low dose dapsone therapy in lepromatous leprosy. | 1975 | 1100970 | |
| minimal inhibitory dosage of rifampicin in intermittent treatment of mycobacterium leprae infection in mice. | the total minimal inhibitory dose of rifampicin determined in the experimental mouse model, was found to be 10 mg/kg body weight, administered once a week for 6 weeks or once every 2 weeks for 12 weeks. from these and other results it is suggested that administration of rmp in human treatment can be reduced to a total amount of 7.2 either as a 600 mg dose once a week for 12 weeks or as a 900 mg dose once a week for 8 weeks. at present these regimens can only be used as an introductory treatment ... | 1975 | 1101580 |
| effect of microbial substances of different origins on the growth of mycobacterium leprae. | mycobacterium leprae multiplied in media enriched with substances originating from other mycobacteria, from non-acid-fast actinomycetales or from gram-positive or gram-negative eubacteriales. most of the m. leprae strains did not grow on a synthetic medium containing the amino acids present in m. smegmatis, but the growth-promoting effect of sonic extracts of this organism indicated that substances of bacterial origin, other than amino acids, do act as growth factors. the identification of the g ... | 1975 | 1102491 |
| the treatment of tuberculosis and leprosy. | 1975 | 1102829 | |
| failure of levamisole to alter the lepromin reaction. | in a study of 37 leprosy patients, the oral administration of levamisole failed to provoke an increase in both the fernandez and mitsuda reactions to lepromins of human and armadillo origin. we interpret this as evidence against an effective specific immunostimulatory capability of levamisole in leprosy patients under the conditions of the study. current knowledge of the mechanism of levamisole action supports the concept that the fundamental immunologic defect in lepromatosus leprosy may reside ... | 1975 | 1103643 |
| repeated tissue sampling with a dental broach. a trial in cutaneous leishmaniasis. | a simple and almost painless technique for repeated sampling of dermal infiltrates with a dendritic broach was used in the diagnosis of cutaneous leishmaniasis. this technique can be used to advantage to obtain organisms and cell underneath crusted lesions and to evaluate not only the number of organisms but also the cell pattern at different depths of the lesion. it can be used repeatedly on the same lesions without appreciably disturbing the natural progress of the disease and is therefore wel ... | 1975 | 1103933 |
| effect of thymectomy and antilymphocyte serum on mycobacterium leprae infection in mice. | balb/c mice thymectomized at 3 to 5 days of age were studied to determine if this procedure would result in enhanced susceptibility to infection with mycobacterium leprae and, if so, whether or not administration of antilymphocyte serum would further increase this susceptibility. the plateau for growth in the footpads of intact mice occurred 4 months after inoculation, whereas in the thymectomized and thymetocomized plus antilymphocyte serum-treated groups the plateau occurred between months 11 ... | 1975 | 1104476 |
| evaluation of "chemical isolation" in 1,168 leprosy patients' homes. | "chemical isolation" (treatment of open cases as a measure of control for transmission between contacts) is evaluated by a retrospective study of 7,232 household contacts of 1,168 leprosy patient homes. contacts comparable in age and type of exposure were arranged in subgroups according to whether they were born before (group a) or born after (group b) beginning treatment of the index cases had begun. additionally, the whole group of contacts, both of open (ll & bb) and closed (tt & i) cases wer ... | 1975 | 1104496 |
| dapsone metabolism in patients with dapsone-resistant leprosy. | 1975 | 1106232 | |
| lepromatous leprosy in the nose after one year of dapsone treatment: clinical and bacteriological findings. | 1975 | 1107725 | |
| lepromatous leprosy in the nose after one year of dapsone treatment: histopathological findings. | 1975 | 1107726 | |
| the fly as potential vector in the transmission of leprosy. | 1975 | 1107727 | |
| multicentre controlled comparative trial of clofazimine and dapsone in low dosages. | 1975 | 1107728 | |
| importance of nasal lesions in early lepromatous leprosy. | there are some 20 million people in the world with leprosy. in the lepromatous form of the illness the nose becomes infected very early in the disease process. the nasal discharge which occurs is heavily bacillated and is the most potent source of exit of mycobacterium leprae from the body. the necessity for early diagnosis and treatment of leprosy in the absence of an effective vaccine is discussed and the pathological changes that occur in the nose are outlined. the roles which the leprologist ... | 1975 | 1108744 |
| minimal inhibitory concentration of dapsone for mycobacterium leprae in rats. | to define the minimal inhibitory concentration (mic) of dapsone (dds) for mycobacterium leprae in rats, we determined the relationship between dietary and plasma levels of dds in uninfected male and female lewis rats. this knowledge was applied to the design of experiments using rats inoculated in the footpads with m. leprae. the mic for dds in male and female rats, respectively, was 1.5 to 4.0 ng and 1.8 to 3.0 ng of dds/ml of plasma, even though the sexes exhibited markedly different concentra ... | 1975 | 1108776 |
| polymorphonuclear activation in leprosy. i. spontaneous and endotoxin-stimulated reduction of nitroblue tetrazolium: effects of serum and plasma on endotoxin-induced activation. | spontaneous nitroblue tetrazolium (nbt) reduction was evaluated in neutrophils from patients with the different types and forms of leprosy, and compared with reduction obtained form cells from normal controls. leucocytes from the same subjects were stimulated in vitro by endotoxin, and the rise in percentage of cells reducing nbt was determined. patients of all groups, with the exception of those with reactional lepromatous leprosy (rll) had an essentially normal proportion of reducing cells. ne ... | 1975 | 1212808 |
| comparison of reactions to human and armadillo lepromins in leprosy. | to assess the usefulness of mycobacterium leprae-infected armadillo tissue as a substitute for human lepromas for the manufacture of lepromin, we compared skin reactions to preparations from these two sources in 115 leprosy patients. the patient sample represented all the primary clinical forms of leprosy. lepromin derived from the armadillo (lepromin-a) provoked the same pattern of responses as human derived lepromin (lepromin-h), i.e., lepromatous patients gave the weakest reactions. lepromin- ... | 1975 | 1240870 |
| [reactional status of leprosy]. | reactional leprosy is studied according to its clinical forms a) lepromatous a) acute lepromatization: encroaching and invasive nature; the patient becomes more and more lepromatous ; bad prognosis. b) erythema nodosum: "contusiform dermatitis"; variable prognosis not so bad as it is in the preceding case; allergic nature and its evolution is usually detained and therapeutics efficient. c) erythema multiform. d) lucio's phenomenon: vascular lesions and consequently necrosis as a complication of ... | 1975 | 1241072 |
| bacteriological status (point prevalence) of lepromatous outpatients under sulfone treatment. | the study concerns 337 outpatients with lepromatous leprosy who had been receiving dapsone treatment for 1-26 years-69% of them regularly and 31% irregularly. routine bacterial examination (10 min per slide) by a paramedical technician showed only 50% of these patients to be bacteriologically positive. this rate attained 99% when each slide was examined for 30-60 min by a qualified bacteriologist. other factors-apart from the limited action of sulfones-might account for these unexpected results: ... | 1975 | 764995 |
| bacillaemia in leprosy. | 1975 | 765273 | |
| schwann cell changes in lepromatous leprosy--an electronmicroscope study. | 1975 | 765274 | |
| development of leprosy in another species of armadillo dasypus hybridus (l): genetic and immunologic implications. | 1975 | 765488 | |
| in vitro cultivation of leprosy bacilli on hyaluronic acid based medium. 1. preliminary report. | in vitro cultivation is reported of mycobacterium leprae on a medium (designated la-3) based on hyaluronic acid with additional ingredients of yeast extract, bovine albumin and glycerin together with phosphate buffer. the medium is also incorporated with agar or agarose (designated la-3p) to serve as culture plates. initial growth in la-3 in test tubes required about six weeks but subsequently this was speeded up to about two weeks utilizing large quantities of media with aeration by shaking twi ... | 1975 | 767262 |
| specific direct fluorescent antibody identification of mycobacterium leprae. | in vitro cultivation of m. leprae requires a rapid, specific identification procedure for monitoring the cultures. a method utilizing direct fitc-coupled lepromatous, specific serum globulin is described in detail with suggestions for improvement. after various purification and adsorption procedures, notably against human liver powder and m. tuberculosis, a fluorescent serum preparation is obtained which specifically reacts with m. leprae and not with other mycobacteria. | 1975 | 767263 |
| [the etiological mystery of sarcoidosis]. | 1975 | 804178 | |
| susceptibility of thymectomized and irradiated mice to challenge with several organisms and the effect of dapsone on infection with mycobacterium leprae. | b6c3f1 mice that had been thymectomized at 8 to 12 weeks of age, subjected to 950 r of whole-body x irradiation, and transfused with syngeneic bone marrow were challenged in a footpad with mycobacterium leprae or m. marinum, or intravenously or intraperitioneally with listeria monocytogenes. also, mice inoculated with m. leprae in a hind footpad were administered dapsone in the mouse chow. the thymectomized-irradiated (t + r) mice did not survive as well as non-thymectomized mice when housed in ... | 1975 | 804443 |
| amyloid-related serum component (protein asc) in leprosy patients. | the presence of amyloid-related serum component, protein asc, in serum samples from 63 leprosy patients was investigated. protein asc was detected in 38% of the patients. a correlation to the disease spectrum of leprosy was apparent: polar lepromatous cases, 64% positive; borderline lepromatous, 50%; borderline tuberculoid, 36%; subpolar tuberculoid, 17%; and polar tuberculoid, negative. antibody activity against the a antigen of mycobacterium leprae was also determined, showing a similar correl ... | 1975 | 804451 |
| antigenic evaluation of mycobacterium lepraemurium. | immunodiffusion analysis of mycobacterium lepraemurium indicated the presence of at lease six antigens. comparative analysis of the m. lepraemurium antigen-antibody system with similar systems established for other mycobacterial species, showed that m. lepraemurium shared up to two antigens with other species. although our observations are in accord with some of the studies on the antigenic mosaic of m. lepraemurium, they are in disagreement with the observations of stanford (1973) concerning a ... | 1975 | 805240 |
| o-diphenoloxidase of mycobacterium leprae separated from infecected armadillo tissues. | we reported earlier the occurrence of a unique o-diphenoloxidase in mycobacterium leprae recovered from lepromatous human tissues. no other source of m. leprae fro biochemical studies was available at the time. in the present report, properties of phenoloxidase in m. leprae separated from infected armadillo tissues are presented. the results show that the o-diphenoloxidase remains unaltered in the passage of the bacilli from the human to the the animal host, indicating that the enzyme is an intr ... | 1975 | 807522 |
| [in-vitro study of the effects of 4,4-diamino-diphenylsulphone in combination with isoniazid and rifampicin (author's transl)]. | 1975 | 810790 | |
| experimental leprosy in the nine-banded armadillo. | 1975 | 813256 | |
| editorials: problems in identifying m. leprae. | 1975 | 815182 | |
| preliminary taxonomic studies on the leprosy bacillus. | antigens extracted from leprosy bacilli obtained from infected human and armadillo tissues have been examined by immunodiffusion analysis with serum samples from lepromatous patients and with immune sera raised in rabbits. using the best combinations of serum and antigen extracts, 12 antigenic constituents were found in the leprosy bacilli. six of these were antigens common to all mycobacteria and nocardiae, 4 were specific to the leprosy bacillus and the position of 2 could not be determined. g ... | 1975 | 816369 |
| mycobacterium leprae in human skeletal muscle. | 1975 | 782385 | |
| letter: identification of mycobacterium ieprae. | 1976 | 782400 | |
| delayed hypersensitivity tests with mycobacterium leprae purified protein derivative. | skin tests were conducted on 3 lepromatous, 3 dimorphous and 6 tuberculoid leprosy patients and 3 others not suffering from leprosy with lepromin, purified protein derivative from m. leprae of armadillo origin and tuberculin. results show that a delayed hypersensitivity reaction could be produced with ppd in 72 hours on all mitsuda positive cases, with one anomalous exception, without cross reaction to tuberculin. the results were promising from the point of view of substituting lepromin with pp ... | 1976 | 1035779 |
| reddening of the upper central incisors associated with periapical granuloma in lepromatous leprosy. | four years after starting treatment for lepromatous leprosy in england a male pakistani aged 26 was found to have red discoloration of the upper central incisor teeth. a radiograph suggested periapical abscess on the right with haziness in a corresponding area on the left. right apicectomy was performed with removal of a solid mass attached to the apex, sections revealing a lepromatous infiltrate with acid-fast fragments of mycobacterium leprae in the cytoplasm of foamy macrophages. clinical and ... | 1976 | 1063039 |
| experimental chemotherapy in leprosy. | the memorandum reviews the considerable progress that has been made in research on the chemotherapy of leprosy during the last 10-15 years, as a result of which it is now possible to study the same topics in leprosy as are studied in other bacterial diseases. thus drugs have been screened in mice for their activity against mycobacterium leprae. those that have been found to have the greatest activity against m. leprae at acceptable dosages-dapsone, rifampicin, and clofazimine-have been character ... | 1976 | 1086735 |
| binding of 14c-labeled dopa by mycobacterium leprae in vitro. | 1976 | 819383 | |
| immunological characteristics of the armadillo, dasypus sabanicola. | the immunological responses of the armadillo are of interest because of its susceptibility to generalized lepromatoid infection with mycobacterium leprae. in this study, specimens of dasypus sabanicola were found to have a typical mammalian distribution of lymphoid cells in thymus, spleen, lymph nodes and blood. their complement was active in bactercidal, protozoan immobilization and haemolytic systems. blood lymphocytes responded to phytohaemagglutinin and to pokeweed mitogen. sensitization wit ... | 1976 | 825337 |
| oxidation of 3,4-dihydroxyphenylalanine by connective tissue constituents. identification of mycobacterium leprae not related to phenolase activity. | the oxidation of 3,4-dihydroxyphenylalanine (dopa) was studied by spectrophotometric methods at ph 6.8. in the presence of l- or d-dopa, a color development occurred in the presence of the following substances as measured by increase in absorption both at 540 nm and 480 nm: hyaluronic acid, trypsinized human skin and umbilical cord extract, trypsin treated rat tissue from subcutaneous rat leproma, trypsin treated m. lepraemurium isolated from rat lepromata, and trypsinized m. leprae isolated fro ... | 1976 | 828625 |
| antimycobacterial antibodies in diffuse lepromatous leprosy detected by counterimmunoelectrophoresis. | by using the counterimmunoelectrophoresis (cie) technic it was possible to demonstrate the presence of antimycobacterial antibodies in the sera of patients suffering from lepromatous leprosy. the antigen was prepared from isolated mycobacterium lepraemurium. the technic was more reliable and quicker than ouchterlony's classical double diffusion in gel. clinical application of the method is therefore recommended. | 1976 | 828626 |
| specificity of o-diphenoloxidase in mycobacterium leprae: an identification test. | 1976 | 828686 | |
| a non-acid-fast coccoid precursor--possible cultivable phase of mycobacterium leprae. | a non-acid-fast coccoid organism isolated from human leproma, and skin and nasal smears of leprosy patients shows tendency to revert to an acid-fast mycobacterial form during test tube passages. one of these coccoid isolates gave strong dopa oxidase activity. there is also preliminary evidence of mycobacterial conversion from these coccoids in intraperitoneally inoculated mice. the possibility that these non-acid-fast coccoids could be a cultivable precursor phase of m. leprae has been raised an ... | 1976 | 828689 |
| evidence for a soluble lymphocyte factor in the transplacental transmission of t-lymphocyte responses to mycobacterium leprae. | 1976 | 768774 | |
| susceptibility of mycobacterium leprae to dapsone as a determinant of patient response to acedapsone. | in the course of a clinical trial of acedapsone therapy in 17 patients with lepromatous leprosy, the rate of response to therapy was measured by inoculation of mice with mycobacterium leprae recovered from biopsy specimens of skin lesions obtained before treatment and at intervals of 4, 12, and 24 weeks after institution of treatment. the susceptibility of each isolate of m. leprae to dapsone (4,4'-diaminodiphenylsulfone [dds]) was measured by passaging organisms that had multiplied in mice to n ... | 1976 | 769667 |
| recent advances in the immunology of leprosy. | 1976 | 770348 | |
| studies of the mouse foot pad technique for cultivation of mycobacterium leprae. 2. the relationship between incubation period and generation time. | 1976 | 772341 | |
| study of sulphone resistance in leprosy patients in india. | 1976 | 772342 | |
| effect of rifampin, clofazimine, and b1912 on the viability of mycobacterium leprae in established mouse footpad infection. | continuous dietary administration of rifampin to mice with an established mycobacterium leprae footpad infection reduced the bacillary solid ratio, with an estimated survival half-life of 5-6 days. in rifampin-treated immunosuppressed animals the survival half-life of solid bacilli, in the absence of host immunity, was 12-13 days. clofazimine and b1912 produced a significant effect on solid ratio only after a lag period of apparently 100 days. the rate of action was considerably slower than that ... | 1976 | 772686 |
| bactericidal action of dapsone against mycobacterium leprae in mice. | dapsone (4,4'-diaminodiphenylsulfone), incorporated into the mouse chow in a concentration of 0.1 g/100 g of diet, was administered for 1 week to mice in which mycobacterium leprae had multiplied to the level of 10(6) organisms/footpad. m. leprae were harvested from these and also from control mice, diluted serially, and inoculated into additional mice. the organisms recovered from untreated mice multiplied in passage with a mean doubling time of 12.2 days, and 35% or more of the inoculated orga ... | 1976 | 773300 |
| hyaluronic acid, b-glucuronidase, vitamin c and the immune defect in leprosy. | 1976 | 773848 | |
| has mycobacterium leprae been cultured in a cell-free artificial medium? | 1976 | 773849 | |
| growth of mycobacterium leprae and m. marinum in congenitally athymic (nude) mice. | 1976 | 785274 | |
| the histopathologic diagnosis of leprosy. | the objective of this paper is to encourage histopathologists to recognize and diagnose leprosy so that it can be treated effectively at the earliest stage possible, before irreversible deformities result. recognition of the earliest form of leprosy-indeterminate-is emphasized. histopathologic descriptions are made and illustrated for the principal types of leprosy. emphasis is placed on (1) the need for dependable acid-fast staining of leprosy bacillus, (2) the non-specific infiltrate in indete ... | 1976 | 785613 |
| editorial: histochemical analysis of leprous tissue leads to cultivation of leprosy bacilli. | 1976 | 786212 | |
| infection of armadillos with mycobacterium leprae. ultrastructural studies of peripheral nerve. | peripheral nerves of armadillos were studied 16 to 30 months after intradermal or intravenous inoculation with mycobacterium leprae. numerous bacilli were found within macrophages, schwann cells, and perineurial cells; endothelial cells, pericytes and fibroblasts were involved as well. the bacilli were characteristically contained in membrane-limited vacuoles that were interpreted as being phagosomes. some of the phagosomes contained granular, membranous, and vesicular debris considered to be ba ... | 1976 | 786213 |
| hepatic granulomas in leprosy. their relation to bacteremia. | a clinicopathologic study of liver disease was conducted on 28 patients with leprosy who lived in taiwan. none of the patients exhibited symptoms or signs of liver disease. hepatic granulomas were found in 21 patients. histologically, the infiltrates were epithelioid, foam cell, and histiocytic in type. hepatic dysfunction was absent, except for mild sulfobromophthalein elevations in the severely infected cases. hepatic granulomas correlated with the cutaneous reactions in lepromatous leprosy, b ... | 1976 | 786214 |
| neonatally thymectomized lewis rats infected with mycobacterium leprae: response to primary infection, secondary challenge, and large inocula. | several experiments were carried out to measure the ability of neonatally thymectomized lewis rats (ntlr) to limit multiplication of mycobacterium leprae. ntlr inoculated in one hind footpad with 10(7) viable m. leprae and challenged in the other hind footpad with 5 x 10(3) organisms simultaneously or 120 or 180 days later permitted multiplication in both sites. by contrast, immunologically intact rats similarly inoculated did not permit multiplication from either inoculum. ntlr and immunologica ... | 1976 | 786892 |
| leprosy-like disease occurring naturally in armadillos. editorial. | 1976 | 787707 | |
| qualitative histology and quantitative bacteriology in various tissues of 50 leprosy patients. | 1976 | 787709 | |
| [culture of leprosy-bacteria in laboratory]. | 1976 | 787746 | |
| separation of m. leprae from human leproma and the development of a cytoplasmic skin test antigen from purified bacilli. | a successful method for purification of m. leprae from human leproma without subjection to heat has been developed. the "floater" phenomenon has been described which consists of bacillary tendency to float in the supernate when bacilli which are not autoclaved are separated from tissues by enzymatic digestion. a method for preparing cytoplasmic fractions from purified m. leprae has been developed for the production of a skin test antigen for leprosy. the cytoplasmic fraction of m. leprae elicit ... | 1976 | 789262 |
| macrophage function in leprosy. | the macrophage function in patients with leprosy was assessed by estimating histochemically the acid phosphatase activity in skin biopsies and by assessment of phagocytic and lytic capability of in vitro cultured macrophages derived from peripheral blood monocytes, challenged with live m. leprae. acid phosphatase was demonstrated in skin biopsies of different groups of leprosy patients classified according to the ridley and jopling scale. the degree of acid phosphatase positivity was correlated ... | 1976 | 789263 |
| "leprosy" in wild armadillos. | 1976 | 789264 | |
| in vitro grown mycobacterium leprae probably a member of the mycobacterium scrofulaceum species. | 1976 | 789265 | |
| lymphocyte transformation test in leprosy; correlation of the response with inflammation of lesions. | lymphocyte transformation tests (ltt) using 'whole washed" and 'sonicated" preparations of mycobacterium leprae (m. leprae) as antigen were studied in eighty-one patients with borderline leprosy. the results were correlated with the histological and the clinical pictures. there was a good correlation with the histological spectrum, ltt responses generally being higher in the borderline tuberculoid leprosy patients and lower in the borderline lepromatous. however, considerable variation was noted ... | 1976 | 791549 |
| early leprosy of the nose and throat. | 1976 | 792374 | |
| attempts at cultivation of mycobacterium leprae in cell cultures. | 1976 | 792535 | |
| the activity of a thiadiazole on mycobacterium leprae. | 1976 | 792890 | |
| loss of infectivity of mycobacterial and protozoal exoplasmic parasites after exposure in vitro to the polyenzymic cocktail 'pigo'. | 1976 | 793902 | |
| dapsone chemotherapy of mycobacterium leprae infection of the neonatally thymectomized lewis rat. | in order to learn whether the neonatally thymectomized lewis rat (ntlr) infected with mycobacterium leprae could serve as a model for chemotherapeutic studies in a situation resembling that found in human lepromatous leprosy, ntlr inoculated with m. leprae either locally or intravenously 9 to 16 months earlier were treated for from 1.5 to 8.5 months with dapsone (4,4'-diaminodiphenylsulfone, dds) incorporated in the rat chow in the concentration providing the minimal inhibitory concentration of ... | 1976 | 795312 |
| electrophoretic patterns of serum proteins and immunoglobulin levels in mycobacterial infections--studies in mice infected with mycobacterium leprae and mycobacterium lepraemurium. | 1976 | 796470 | |
| autoradiographic studies of mycobacterium leprae. | 1976 | 796603 | |
| studies of the mouse foot-pad technique for cultivation of mycobacterium leprae. 4. statistical analysis of harvest data. | 1976 | 796604 | |
| report of the second immlep task force meeting 1-5 december, 1975. | 1976 | 796605 | |
| immunology and animal experimentation in leprosy. | 1976 | 797549 | |
| the effect of dioxyphenylalanine (dopa), amides and some potential sources of energy on the multiplication of mycobacterium leprae. | the multiplication of 2 out of 3 m. leprae strains on a medium containing substances from digested non-acid-fast microorganisms or even free of them was significally promoted to d-3,4-dihydroxyphenylalanine (dopa). the following organic substances exerted growth-promoting effects on several strains: 0.02-0.10% concentrations of succinate greater than fumarate greater than alpha-ketoglutarate and acetate greater than glycerol; 0.2% concentrations of citrate and pyruvate greater than isonicotinami ... | 1976 | 798593 |
| [experimental chemotherapy of leprosy]. | 1976 | 798637 | |
| activity of ascorbic acid in inhibiting the multiplication of m. leprae in the mouse foot pad. | ascorbic acid was fed to mice in concentrations of 0.05%, 0.15%, and 0.45% w/w in the diet. six months after inoculation of m. leprae into the foot pads, there were significantly fewer acid-fast bacilli harvested from animals receiving 0.15% and 0.45% w/w ascorbic acid than from control mice. on the other hand, m. leprae did multiply in mice fed ascorbic acid while no multiplication at all was observed in animals fed dapsone, clofazimine or rifampin. no toxic effects of ascorbic acid were noted ... | 1976 | 798727 |