Publications

[bactericidal effect of disinfectants on various strains of mycobacterium tuberculosis].		1979	113848
[preventive and therapeutic application possibilities of newer antibiotics (author's transl)].	today, however aminoglycosides are nearly indispensable owing to their broad antibacterial spectrum and genuine bactericidal effect as well as the possible synergic effect with beta-lactam preparations. the new cephalosporins are distinguished by a high beta-lactam stability and are active against the majority of pathogens causing nosocomial infections. an exceptional position is held by cefotaxim with its generally outstanding antibacterial potency, and by cefoxitin with its activity against ba ...	1979	114782
measles virus induced lectin binding in cultured, aortic cells.	using the indirect hemadsorption test it was shown that cultured diploid cells of mini-pig, monkey or human aortic origin develop wheat germ lectin/wga/binding capacity following infection with measles virus. heteroploid cell lines of similar origin have bound wga also without being infected with virus. the possible role of virus induced membrane changes in vascular cell pathology is suggested by the results presented.	1979	114964
[occurrence of gonococci with reduced sensitivity in samples tested at the county hospital in dresden between 1975 and 1977].		1979	115163
[haemophylus influenzae. morbidity and the problem of specific prevention].		1979	115185
nitroblue tetrazolium (nbt) reduction by bacteria. some properties of the reaction and its possible use.	all the s. albus, e. coli and p. aeruginosa strains examined reduced nitroblue tetrazolium (nbt) to dark blue formazan. the amount of formazan produced was proportional to the number of bacteria. under the same growth conditions, an equal number of bacteria of various strains produced different amounts of formazan. however, there were statistically verified differences in the nbt-reduction between the three species examined. the nbt-reduction took place in all phases of growth but was most inten ...	1979	115226
pharmacological modification of experimental tardive dyskinesia.	cebus apella monkeys subjected to chronic haloperidol administration develop neurologic disturbances very similar to neuroleptic-induced acute dystonia human beings. after varying lengths of time, certain monkeys develop a prolonged dyskinetic syndrome resembling tardive dyskinesia (td), as seen clinically. two monkeys with signs of td were given single intramuscular injections of various compounds with known effects on the catecholaminergic, cholinergic, serotoninergic and gaba-ergic neurotrans ...	1979	115227
a pharmacological and in vitro comparison of three oral cephalosporins.	the pharmacology of cephradine, cephalexin and a new oral cephalosporin, cefaclor, has been compared in six volunteers. cefaclor was absorbed rapidly and was cleared from the serum more rapidly than the other two agents. this was probably partially due to its instability in serum at body temperature, which was investigated. against a wide range of common pathogens cefaclor was the more active oral cephalosporin. in particular the activity against neisseria gonorrhoeae and haemophilus influenzae ...	1979	115833
commissural columns in the sensory-motor cortex of monkeys.	callosally projecting cells and the terminal ramifications of their axons were identified in the monkey sensory-motor cortex by retrograde and anterograde labeling techniques, often by double labeling cells and axons in the same animal. bundles of callosal fibers terminate in small column-like zones 0.5-1 mm wide in the motor cortex (area 4) and in the first (si) and second (sii) somatic sensory areas. such columns are aligned in register to form elongated strips extending mediolaterally in the ...	1979	115905
[an experimental study on pseudomonas osteomyelitis with special reference to the production of experimental osteomyelitis in mice (author's transl)].	i) the author has successfully produced a model of experimental osteomyelitis caused by pseudomonas aeruginosa using the following procedure though such a demonstration has been said to be very difficult. after impregnation in a solution containing about 10(5) pseudomonas aeruginosa, 3 mm silk thread of no. 5 was dried under low-pressure atmosphere and then inserted into the metaphysis of right tibia of a mouse. this method can be produced experimental osteomyelitis in 100% of the animals. in th ...	1979	115949
putreanine in developing monkey brain: relation to polyamines.		1979	115966
long-term effects of early undernutrition and environmental stimulation on learning performance of adult rats.	early undernutrition was achieved in rats by increasing litter size; the undernourished groups were reared from birth to 21 days in litters of 18 pups per dam and the control groups in litters of six pups per dam. each of these groups was divided at weaning into two sub-groups: previously undernourished, stimulated (pus+) and non-stimulated (pus-); and control, stimulated (cs+) and non-stimulated (cs-). from weaning, all animals were fed ad libitum. environmental manipulation began at weaning an ...	1979	115974
focal epithelial hyperplasia in rabbit oral mucosa.	several papules on the floor of the mouth and the ventral surface of the tongue of a zinc-deficient rabbit were studied by light and electron microscopy. these papules appeared to be consistent with focal epithelial hyperplasia of man and chimpanzees. there was a concurrence of cytoplasmic vacuolization with the appearance of viral particles within the nucleus. intranuclear crystalline viral aggregates were frequently observed in the upper spinous cells.	1979	115979
influence of dietary protein on the anti-inflammatory and ulcerogenic effects and on the pharmacokinetics of phenylbutazone in rats.	influence of dietary protein deficiency on the anti-inflammatory and ulcerogenic effects and on the kinetics of phenylbutazone was studied in male sprague-dawley rats fed ad libitum a 21% (control) or a 5% (low) protein diet for 3 weeks. a low protein diet fed to a decrease in body weight gain, plasma proteins, albumin, globulins, hepatic total and microsomal proteins and in cytochrome p-450. phenylbutazone produced a greater ulcerogenic effect in rats fed a low protein diet than in control rats ...	1979	115991
organization of nucleolar dna in resting lymphocytes as revealed by the diaminobenzidine technique.		1979	116008
dietary salt (sodium) and hypertension.		1979	116541
effects of biorhythms on blood flow distribution in the pregnant uterus (macaca mulatta).	ten rhesus monkeys were studied between 143 and 161 days of gestation. the unanesthetized animals were confined to restraining chairs and maintained in a controlled environment with continuous monitoring of spontaneous uterine dynamics. forty-five determinations of blood flow distribution were made using radionuclide-labeled microspheres. the microsphere injections confirmed a circadian pattern of uterine blood flow. these biorhythms are related to alterations in distribution of blood flow to pl ...	1979	116548
mineralization of the enamel of ovine permanent central incisor teeth using microhardness and histological techniques.		1979	116728
restriction of plasmid-mediated transformation in bacillus subtilis 168.	when plasmids carrying leucine genes of bacillus subtilis 168 were isolated from a restriction and modification deficient (r-m-) strain and used for transformation of a restricting strain b. subtilis 168 leu rece4, the number of transformants was greatly reduced. transformation of rec+ strain (transformation by integration of the donor dna into the chromosome) with the plasmids was not affected irrespective of whether the recipient carried the r+ or r- phenotype. these results show that the plas ...	1979	117281
study of the anti-tumor effect of polypeptide pineal extract.	bovine pineal polypeptide extract (ppe) exerted an anti-tumor effect on mouse-transplantable tumors: mammary cancer (rsm), squamous cell cervical carcinoma (scc), hepatoma-22a and lympholeukemia lio-1, and had no effect on harding-passey melanoma and leukemia l-1210. it was shown that ppe possessed the ability to decrease the incidence of dmba-induced mammary adenocarcinomas in rats. the daily administration of 0.5 mg ppe prolonged the life span of rats by 25% and failed to influence spontaneous ...	1979	117414
cost-benefit studies of vaccinations in finland.	the benefits of vaccination are, in general, recognized. for some diseases these benefits are obvious. when starting or evaluating new vaccination programmes, a more critical approach is needed. before starting vaccination against measles and rubella in finland a cost-benefit study was performed. according to those studies the net benefits of each vaccination would be ca. 100 million finnish marks in 25-30 years. those benefits not measurable in money value of human life, decrease of suffering, ...	1979	118069
[modelling modification of chemical mutagenesis in human cells. iii. linear index of protection as the standardized criterion of modification].	the effect of substances with radioprotective activity, apaetp 2,3 (aminopropylaminoethylthiophosphoric acid 2,3), apaetp 3,3 and cystaphos, on chromosome aberrations, induced by thiotepa in the culture of human lymphocytes was investigated. it is shown that the obtained curves "concentration -- effect" for thiotepa can be described by equations rho = 1 -- e-(kc + alpha)2 and x = e -(kc + alpha)2 --1 for aberrant cells and for chromosome breaks in the presence of the investigated substances. on ...	1979	118079
isolation and characterization of recombinant dna plasmids carrying drosophila trna genes.	recombinant plasmids carrying drosophila melanogaster trna genes were constructed by ligation of hindiii-cleaved drosophila dna to hindiii cut pbr322 dna. 90 clones were isolated that contained genes for one or more of eleven trnas. 43 of the plasmids were characterized by a number of methods: restriction nuclease digestion; agarose gel electrophoresis; hybridization with individual, purified, 125i-labelled drosophila trna molecules and in situ hybridization to drosophila chromosomes. the result ...	1979	118082
significance of the detection of beta-galactosidase and of beta-xylosidase in the taxonomic study of the genus haemophilus.	a total of 314 strains of haemophilus, isolated from clinical samples, were studied for the production of beta-galactosidase and beta-xylosidase. none of the h. influenzae strains studied (9 beta-lactamase positive strains and 129 beta-lactamase negative strains) possessed these enzymes. both enzymes were almost constantly observed among strains of h. paraphrophilus (10 strains studied) and of h. paraphrohaemolyticus (9 strains studied). among the other species (h. parainfluenzae, 55 strains; h. ...	1979	118191
comparison of two antigen detection techniques in a primate model of haemophilus influenzae type b infection.	rapid diagnosis of haemophilus influenzae type b meningitis is possible using immunological tests for capsular antigen (polyribophosphate, prp), such as countercurrent immunoelectrophoresis (cie) and latex particle agglutination (lpa). we compared two tests in monkeys with evolving, serially quantitated h. influenzae type b bacteremia (n = 23) and meningitis (n = 21). in vitro, the lpa test was sensitive to 0.5 ng of prp/ml of saline, and the cie test was sensitive to 1.0 ng/ml; in serum, howeve ...	1979	118934
serological grouping of meningococci and encapsulated haemophilus influenzae strains by latex agglutination.	the latex agglutination method, utilizing antibody-coated latex particles, was adapted for serogrouping of neisseria meningitidis and serotyping of encapsulated haemophilus influenzae strains from agar plates. it was found to give more clear-cut results than conventional slide agglutination. a 100% agreement with the antiserum agar method was found for all strains isolated from blood or cerebrospinal fluid. many meningococcal strains from nasopharyngeal carriers are autoagglutinable, but some of ...	1979	118981
[drug resistance of bacteria isolated from patients with chronic nonspecific broncho-pulmonary diseases].		1979	119214
[studies on the influence of various factors in phagocytic process with sera of rabbits immunized by an extract from "haemophilus influenzae" type a (author's transl)].		1979	119456
effect of antibiotics on the formation of specific antibodies.	immune response to staphylococcal haemolysin and haemophilus influenzae capsular antigen administered simultaneously with antibiotics was studied in rabbits. in addition to specific humoral antibodies, the quantitative values of igg, iga, igm and c'3 complement were determined. statistically significant deficiency of immune response was observed in all cases in animals which were given the antigen with the antibiotic in comparison with the controls which were immunized by the antigen alone. stat ...	1979	119810
nucleotide binding to glycogen phosphorylase b in the crystal.		1979	119868
pharyngeal beta-hemolytic streptococci: a study in american military dependent children stationed in west germany.		1979	119925
effect of inosine on warm renal ischemia in monkeys and dogs.		1979	120023
synchronization of eeg activity of male rhesus monkeys macaca mulatta treated with ovocyclin.	bipolar stainless steel electrodes were stereotaxically implanted in hypothalamus and cortex of six male monkeys. the effect of intramuscular injection of estradiol dipropionate (ovocyclin) in a dose of 10 mg/d was observed on eeg activity on 3 successive days. on the first day, slow waves appeared only in preoptic and on the second day also in posterior hypothalamus. generalized slowing with an increase in amplitude appeared in all the hypothalamic areas and cortex on the third day. this sugges ...	1979	120113
residues of ddt in a norwegian fruitgrowing district two and four years after the termination of ddt usage.	this study describes the extent of ddt contamination in a typical fruit growing district in norway two and four years after the ddt ban. residues of ddt in man, dairy cows and soil were about five to one hundred times higher than in the control groups, while residues found in samples from the marine biota were the same or moderately higher (figure 3). the residues of ddt in cows, gulls and parts of the marine samples showed a significant decrease from 1972 to 1974, while the level in soil was al ...	1979	120139
[effect of enkephalin and morphine on gastric secretion and gastric blood flow].		1979	120296
nervous functioning during ontogenesis: facts and reflections.		1979	120624
lipid pattern of erythrocyte membrane of calf and adult cattle.		1979	120656
experimental studies on the mechanism of the nitroglycerin effect.	the regional decrease of the speed and extent of the contraction and the relaxation of the canine myocardium induced by coronary ligation was enhanced by intravenously administered nitroglycerin (gtn), simultaneously with the decrease of the left ventricular pressure, while the increase of myocardial fiber length caused by that procedure was partly abolished. the above changes could be reproduced by gtn applied directly onto the ischaemic myocardial surface even before the decrease of the left v ...	1979	120673
[measles and temporary increase in masculine births: coincidence or causality?].	data from three west-african populations shows significant increase of sex-ratio. in two of them a considerable excess of male births came from conceptions the year following an epidemic of measles. this is limited to the villages affected by this epidemic. these facts seem to be similar to those related to hepatitis and sex-ratio. they suggest similarities between measles virus and surface antigens of y sperms. this hypothesis could be tested by immunological investigation.	1979	120780
[identification of a virus similar to hepatitis b virus in non-a non-b hepatitis].	hepatitis b virus-like particles (including dane particles) with dna polymerase activity but negative for hbs ag have been identified in non-a, non-b hepatitis sera positive for hc ag. although specifically associated with the particles, hc ag is not a surface antigen of the hepatitis c virus identified here for the first time. the relationship of this agent with hbv seems obvious, and deserves further study.	1979	120782
[vitamin d and reproduction in wistar rats].	females have received from weaning a semi-synthetic diet (0,35% ca; 0,32% p; 0,03% mg), with or without vitamin d (+/- d). fertility of these females was not changed. at weaning, the young from mothers--d had lower weight, calcemia and phosphatemia, but the ash content of the femur was the same as for young from mothers + d. young rats from mothers +/- d were given the diet with or without vitamin d. 19 days after weaning, the diet of the mother (+/- d) appears to be the principal factor for gr ...	1979	120790
[effect of progesterone on male and female sex behavior induced by steroid hormones in adult ovariectomized ewes].	ovariectomized adult ewes daily treated with i/m injections of testosterone propionate (10 mg/day) or oestradiol benzoate (200 microgram/day) show male-like sexual behaviour and simultaneously a permanent female receptivity. additional daily treatment with 100 mg of progresterone results in a rapid decrease in male sexual responses both when ewes are treated with testosterone and with oestradiol. no effect is observed on the female receptivity. cyproterone acetate (100 mg/day) given to ewes in a ...	1979	120792
barbiturates in neurosurgery.		1979	120795
the influence of the mode of morphine administration on tolerance and dependence.		1979	121358
the effect of l-alpha acetyl methadol in morphine-dependent rats.		1979	121361
the ultrastructural features of laser trabeculopuncture and cyclodialysis. problems related to successful treatment of chronic simple glaucoma.	microexplosions induced by a q-switched nd:glass laser working above optical breakdown power density levels are able to destroy the inner wall of schlemm's canal and to tear open both the supraciliary and suprachoroidal space. furthermore, the ciliary muscles bundles may be disrupted, becoming subsequently permeable to the aqueous and thus also acting as a new outflow route. however, whereas breaks of the inner wall of schlemm's canals are sealed in the monkey by the activity of endothelial cell ...	1979	121373
[therapy of chronic respiratory tract infections in children, including mucoviscidosis (author's transl)].	in respiratory tract infections in children a distinction must be made between frequently recurring infections and genuine chronic infections due to specific anatomical factors, immunological defects or congenital diseases such as mucoviscidosis. the most frequent pathogens are haemophilus influenzae, pneumococci, staphylococcus aureus, streptococcus pyogenes, enterococci, pseudomonas aeruginosa and klebsiella, s. aureus predominates in infants. the same applies for mucoviscidosis, in which p. a ...	1979	121731
bacterial transformation.		1979	121792
mutagenicity of nitrosocarbaryl and other methylating nitrosamides as related to uptake in haemophilus influenzae.	differences greater than 6,000-fold in the mutagenic potency of three nitrosamides that are methylating agents [n-methyl-n-nitrosourea (mnu), n-methyl-n'-nitro-n-nitrosoguanidine (mnng) and n-nitrosocarbaryl (nc)] could be accounted for in part by differences in their uptake into the haemophilus influenzae cells. uptake was roughly correlated with the octanol/water partition coefficient. the most potent mutagen, nc, was concentrated by the cells. the least potent, mnu, was essentially excluded f ...	1979	121978
[distribution of different phage types of s. paratyphi b in spain].		1979	122277
specificity of dna uptake in genetic transformation of gonococci.		1979	107953
influence of clofibrate on hepatic transport of bilirubin and bromosulfophthalein in rats.		1979	107954
[some physico-chemical properties of the compact chromosome of ananbaena variabilis].	it was shown that total dna of the blue-green algae a. variabilis can be isolated as a compact particle with the sedimentation constant of 2700--2900s by lysis of the cells with the tritonx-100--sodium deoxycholate mixture in 1.0 m nacl. the structure isolated is sensitive to ribonuclease and the hydrodynamic shift. it was found that within a compact chromosome a. variabilis dna is circular and negatively superhelicized. the density of superturns of the dna in 0,2 m nacl at 20 degrees c is 0,061 ...	1979	107975
induction of reaginic (ige) gonococcal antibodies in the rat by a common antigen of neisseria gonorrhoeae.	an antigen (zab) common to neisseria gonorrhoeae was prepared by stepwise elution of a crude gonococcal antigen (za) from columns of diethylaminoethyl cellulose employing 0.02 m phosphate buffers, ph 7.6, containing increasing concentrations of sodium chloride. rats immunized with zab produced reaginic (ige) antibody which cross-reacted with za prepared from eight gonococcal strains by the passive cutaneous anaphylaxis (pca) test. heating of the sera at 56 degrees c for 4 h destroyed the pca act ...	1979	108009
[stimulation of g-6-p independent glycogen synthase activity in the human placenta].	in immature human placentas, the activity of the i (glucose-6-phosphate-independent) form of glycogen synthase is significantly increased by insulin, glucose and by both compounds associated. in full-term placentas, the same kind of results has been found in each organ studied; due to the great variability observed in synthetase i control activities, the stimulation is significant only in the presence of insulin.	1979	108019
131i-6-iodocholesterol, an agent for imaging the adrenal gland.		1979	108055
[effect of a combination of 3 pesticides on the sensitization of guinea pigs to ovalbumin].	the author treated guinea pigs with a combination of three pesticides: first group -- with cyneb in a dose of 12,5 mg/kg of body weight (threshold value) +/- sevine in a dose of ip 5 mg/kg (twice threshold value) +/- tribufon in a dose of 5.0 mg/kg (threshold value); second group -- cyneb 125 mg/kg (ten times of threshold value) +/- sevine 1.5 mg/kg (twice the threshold value) +/- tribufon 5.0 mg/kg (threshold value). two groups of animals were used as controls: first group-- treated with 2,0 mg ...	1979	108072
altered hypothalamic-pituitary regulation of thyrotropin in male rats during aging.		1979	108086
response of human growth hormone, prolactin and thyrotropin to thyrotropin releasing hormone in liver cirrhosis and diabetes mellitus.		1979	108097
insulin receptors and functions in normal and spontaneously transformed cloned rat hepatocytes.		1979	108115
responses of single units in the monkey superior colliculus to stationary flashing stimuli.	1. responses of pan-directional cells in the superficial layers of the superior colliculus in paralysed anaesthetized rhesus monkeys to stationary flashing stimuli have been studied. 2. the receptive field centre response is always of the transient excitatory on-off type, while the surround response is transient inhibitory both at light-on and at light-off. the receptive field centres are circular or slightly elliptical. the average size of the receptive field centres is much larger than that of ...	1979	108123
effects of increasing mg++ ion concentration on the pku monitoring assay.	inaccuracies in a commonly used bacterial inhibition assay for blood phenylalanine levels arise when the mg++ ion concentration in the assay medium is increased. this has practical implications in the diagnosis and management of phenylketonuria.	1979	108130
gene expression during development of myxococcus xanthus: pattern of protein synthesis.		1979	108160
[lactic acid bacteria and streptococci of the human stomach normally and in pathological processes].	lactic acid bacteria were either absent or present in negligent quantities in the stomach of apparently healthy man. but in case of various pathological processes in the stomach and duodenum lactic acid bacteria accumulated (up to a million cells per 1 ml of gastric contents). under these conditions coccal forms sharply prevailed over the bacillary ones. in patients with chronic gastritis and peptic ulcer of the stomach the most frequent were streptococcus faecalis and its variants; in oncologic ...	1979	107685
the viability of cryopreserved aegyptianella pullorum carpano, 1928 in the vector argas (persicargas) walkerae kaiser and hoogstraal, 1969.		1979	107668
[determination of the mouse glomerular filtration rate by total 51cr-edta plasma slope clearance depending on age and sex].		1979	107677
[action of secretin on the gastric secretion induced by food stimuli, pentagastrin, histamine and the parenteral administration of casein hydrolysate].	in tests on dogs with innervated and vagus denervated miniature stomaches and gastric fistula the action of secretin on the gastric secretion provoked by food stimulants-pentagastrin, histamine and parenteral introduction of casein hydrolysate was studied. experiments showed the secretin to produce an inhibiting action only on the 2nd phase of the gastric secretion after feeding on 100 g of meat, depresses secretion, called forth with pentagastrin, but it does not affect the secretion induced by ...	1979	107652
ischemic brain edema: comparative effects of barbiturates and hypothermia.	the effect of pentobarbital and hypothermia on the development of ischemic brain edema was studied in 23 rhesus monkeys undergoing transorbital middle cerebral artery occlusion. fifteen additional animals served as unclipped controls. regional cortical cerebral blood flow (rcbf), arteriovenous oxygen content difference (avdo2), and regional cortical metabolic rate of o2 (rcmro2) were measured hourly until sacrifie 11 hours postocclusion, at which time ischemic cerebral edema was measured. in 8 a ...	1979	107624
interpretation of serum and red cell folate results. a comparison of microbiological and radioisotopic methods.	serum folate and red blood cell folate levels were measured in 167 patients using a microbiological method (lactobacillus casei) and a commercial 125i radioassay kit. the results of the two methods were compared and related to the clinical findings to see which method more truly reflected the physiological folate status of the patient. there was a good linear correlation between the methods for both serum folate and red cell folate over the whole range encountered and the mean results obtained w ...	1979	107505
[anabolic effects of steroid hormones in rabbits (author's transl)].	the anabolic effect of steroid hormones was investigated in rabbits by measuring the skeletal accumulation rate of 85sr following the continuous administration of estrogens, androgens and corticosteroids over a period of eight weeks. androgenic hormones did not influence the accumulation rate of 85sr, whereas following castration and prolonged administration of estrogens an increase of 85sr accumulation was found. there was no correlation of the changes observed with serum calcium levels, since ...	1979	107513
survival of transplanted normal hepatic cells in bilirubin udp-glucuronyl transferase deficient gunn rat liver.	the survival of h3 thymidine labelled normal rat hepatic cells after transplantation into the gunn rat liver has been investigated. it was found that 0.9% of the cells survived at least 12 weeks after transplantation. this suggests that the observed uridine diphosphoglucuronyl transferase (udpgt) activity in the genetically deficient gunn rats after transplantation of normal liver may be partially due to these cells. time required for the transplantation procedure has a profound effect on the su ...	1979	107547
immunoglobulins g, a and m in normal and pathologic human sera determined with the spot immunoprecipitate assay (sia) in multi-assay plates.	a simple rapid spot immunoprecipitate assay (sia) is presented. the antigen--antibody reaction takes place in a field of alternating current; small amounts of specific antisera are used, and the influence of diffusion or electromobility of the antigen is avoided. determinations of igg, iga and igm in sera from healthy individuals correlated highly significantly with radial immunodiffusion (rid) results. the reaction conditions in sia, particularly the availability of a sufficiency of specific an ...	1979	107578
primate brain nerve cells bulk isolated by the perfusion method.		1979	107460
bacteriophage lambda-e. coli k12 vector-host system for gene cloning and expression under lactose promoter control. ii. dna fragment insertion at the vicinity of the lac uv5 promoter.	bacteriophage vectors derived from lambda plac5 have been constructed. their genomes have one ecori restriction site which is located at the very beginning of the lac z gene. the major part of this gene was deleted by an in vivo intramolecular recombination. these vectors allow the fusion of a gene or an operon with the beginning of the lac z gene, placing them under the control of the lac promoter, which carries the uv5 mutation. some of these vectors (lambda y) also include the lac y gene and ...	1979	107393
[the isolation of chlamydia in the male urogenital tract].		1979	107412
advanced trauma life support laboratory: pilot implementation and evaluation.	selected invasive diagnostic and therapeutic techniques were taught to emergency physicians through modular advanced trauma life support (atls) animal laboratory courses presented in the fall of 1977. thirty-seven emergency physicians participated in the four pilot atls laboratories in which the average trainee:animal:instructor ratio was 2:1:0.75. the animals consisted of 15 large baboons and five large rhesus monkeys. cost accounting on these pilot atls courses revealed that the total program ...	1979	107357
absence of indoleamine-accumulating neurons in the retina of humans and cynomolgus monkeys.	indoleamine-accumulating neurons have previously been detected in cats, rabbits, goldfish, chicken, pigeons, and cebus monkeys, and were therefore also looked for in humans and in old world monkey. cynomolgus irus. the monkey eyes were injected intravitreally with 50 microgram 5,6-dihydroxytryptamine, 5 microgram alpha-methylnoradrenaline, or both drugs simultaneously. the human retinas were incubated in either drug. previous observations on the distribution of dopaminergic neurons were confirme ...	1979	105648
the number and distribution of mast cells in monkey lungs.	we estimated the number of mast cells in monkey lungs by both quantitative histologic examination and measurement of total lung histamine, and showed that monkey lungs contain between 10(7) and 10(8) mast cells, with approximately 83% of these being located in conducting airways, and 17% in the parenchyma. the number of mast cells found in each airway generation increased from approximately 60,000 in the trachea to 8 million in the terminal bronchioles. in airways from different generations the ...	1979	105654
[detection of liver microbascess due to candida albicans by liver biopsy in a patient with leukemia during complete remission: report of a case (author's transl)].		1979	107251
pseudomonas aeruginosa bacteremia: relationship of bacterial enzyme production and pyocine types with clinical prognosis in 100 patients.	strains of pseudomonas aeruginosa were studied from 100 patients with bacteremia. in vitro quantitation of extracellular enzymes (lecithinase, protease, and elastase) and pyocine typing of these isolates were performed. no significant difference was found in the quantity of the enzymes produced or in the pyocine types by isolates obtained from patients dying from bacteremia or surviving this serious infection. quantitation of the extracellular enzymes and pyocine types of blood isolates were con ...	1979	107256
tumor-host responses to various nutritional feeding procedures in rats.	parenteral and enteral nutrition are being used as adjuncts to cancer therapy. a liquid diet formulation containing a 27% solution of glucose and 3.9% crystalline amino acids with electrolytes and vitamins was given continuously for a week via parenteral (iv), and via intragastric (ig) routes and also was given ad libitum via the oral or per os (po) route to groups of buffalo rats with and without a morris no. 7777 transplantable hepatoma to find out how these feeding procedures affect tumor-hos ...	1979	107299
thyroid function in preterm infants with respiratory distress syndrome.	thyroid function was evaluated in premature infants 30 to 35 weeks ega with severe rds and was compared to that of healthy control subjects of similar ega. the infants with rds had significantly lower serum levels of t3, t4, and ft4i during the first 60, 90, and 30 days, respectively, and had elevated t3ur during the first 10 days. the mean (+/- sd) postdelivery tsh peak was lower in the rds group (32.8 +/- 9.6 muu/ml) than in the control group (60.9 +/- 21.8 muu/ml; p less than 0.005). after tr ...	1979	107304
central effect of taurine and its analogues on fever caused by intravenous leukocytic pyrogen in the rabbit.	1. taurine infused i.c.v. after i.v. injection of leukocytic pyrogen (lp) inhibited the initial rise in body temperature and prolonged fever when infusion was stopped. 2. similar infusion of taurine also inhibited the hypertermic effect of i.c.v. pge2 (0.5 microgram) but did not cause prolonged hyperthermia. 3. i.c.v. administration of the taurine analogues hypotaurine and beta-alanine, compounds which have been shown previously to compete with taurine for facilitated transport in c.n.s. tissue, ...	1979	107309
percutaneous nitroglycerin absorption in rats.	percutaneous nitroglycerin absorption was studied in shaved rats by monitoring unchanged plasma drug concentrations for up to 4 hr. drug absorption from the neat liquid state or from an alcoholic solution was considerably poorer than that from a commercial ointment. this observation was unanticipated since the driving force for percutaneous drug absorption was assumed to be drug thermodynamics. potential artifacts such as drug volatilization from the skin, reduction of surface area through dropl ...	1979	107313
phospholipid synthesis-dependent activity of aminopeptidase n in intact cells of escherichia coli.		1979	107320
deoxythymidine nucleotide metabolism in bacillus subtilis w23 infected with bacteriophage sp1oc: preliminary evidence that dtmp in sp10c dna is synthesized by a novel, bacteriophage-specific mechanism.	despite the fact that mature sp10c dna contains dtmp, the acid-soluble fraction of infected cells contained no dttp during the interval of phage replication. however, infected cells contained normal cellular levels of datp, dgtp, and dctp. upon infection of deoxythymidine-starved bacillus subtilis m160 (a deoxythymidine-requiring mutant of b. subtilis w23), mature phage dna with a normal dtmp content was made. sp10c codes for an enzyme that seems to catalyze the tetrahydrofolate-dependent transf ...	1979	107324
in vitro antimicrobial activity of piperacillin and seven other beta-lactam antibiotics against neisseria gonorrhoeae and haemophilus influenzae, including beta-lactamase producing strains.		1979	107152
serotypes and antibiotic susceptibilities of pseudomonas aeruginosa isolates from single sputa of cystic fibrosis patients.	a phenotypic characterization of pseudomonas aeruginosa from single sputum samples of 21 typical cystic fibrosis patients indicated a high frequency of heterogeneity among isolates on the basis of differences in antibiotic resistance, colony morphology, pigmentation, and serotype. two or more isolates with different but stable susceptibilities to carbenicillin, gentamycin, streptomycin, tetracycline, chloramphenicol, and sulfamethoxazole plus trimethoprim were detected in 38% of the sputa. diffe ...	1979	107186
recovery of spores from impregnated filter paper.		1979	107200
association of beta-glucosidase with intact cells of thermoactinomyces.	the location of the b-glucosidase activity in a whole culture broth of the thermophilic organism thermoactinomyces has been studied. little beta-glucosidase activity was found in the culture filtrate, while the culture solids contained the major part of the activity of the whole culture broth. the activity does not appear to be adsorbed to the culture solids; rather there is evidence that it is an intracellular soluble enzyme(s). the ph and temperature optima for a crude beta-glucosidase prepara ...	1979	106906
[modeling of determinant and dependent foci of epileptic activity in the rat cerebral cortex].	foci of increased excitability were created in acute experiments on rats by means of weak strychnine solutions working at independent regimens. the hyperactive excitability focus induced by means of concentrated strychnine solutions played the role of a determinant structure. the importance of the latter is in the fact that it determines the activity character of other epileptogenic foci, enhances their convulsive activity, unites them into a single functional complex and determines the behaviou ...	1979	106910
production, purification, and properties of dextransucrase from leuconostoc mesenteroides nrrl b-512f.	the production of dextransucrase from leuconostoc mesenteroides nrrl b-512f was stimulated 2-fold by the addition of 0.005% of calcium chloride to the medium; levansucrase levels were unaffected. dextransucrase was purified by concentration and dialysis of the culture supernatant with a bio-fiber 80 miniplant, and by treatment with dextranase followed by chromatography on bio-gel a-fm. a 240-fold purification, with a specific activity of 53 u/mg, was obtained. contaminating enzyme activities of ...	1979	106966
liver transplantation.		1979	107000
effect of pregnancy and lactation on glycosyltransferase activities of rat mammary gland.		1979	107054
carboxypeptidase of streptomyces griseus. implications of its characteristics.		1979	106886
[multiple molecular forms of erythrocyte carbonic anhydrase of sheep (author's transl)].	three major forms ci, cii and cx and the minor component ci1v of ovine erythrocyte carbonic anhydrase have been identified in the ethanol chloroform extract of the hemolysate by electrophoresis on cellulose acetate and isoelectrofocusing. isolation of the four forms was achieved by chromatography on deae-sephadex a-50. comparative studies suggest that: (1) form ci1v is a modified form of ci, (2) form cx is ci plus glutathione and (3) forms ci and cii are isoenzymes which differ in their primary ...	1979	106895
artifacts in isoelectric focusing of the microsomal enzymes cytochrome p-450 and nadph-cytochrome p-450 reductase.	highly-purified rat liver microsomal cytochrome p-450 and nadph-cytochrome p-450 reductase (nadph-ferricytochrome oxidoreductase, ec 1.6.2.4) preparations gave rise to a large number of bands under a variety of isoelectric focusing conditions, as observed after staining for either zymogen or protein. the binding patterns were not independent of sample concentration and position of application, and eluted bands did not refocus as expected. the artifactual heterogeneity is attributed to strong pro ...	1979	106898
animal models for the comparative assessment of neurotoxicity following repeated administration of vinca alkaloids.	neurotoxicity is the major side effect occurring during the clinical use of vincristine (vcr). animal models predictive of potential neurotoxicity would be very useful in the preclinical development of new vinca compounds. to simulate conditions in which neurotoxicity is produced during the clinical use of vcr, experimental animals (except the guinea pig) were given the test compounds by the iv route over a prolonged time period. doses were selected based on the production of leukopenia. vindesi ...	1979	105807
measurement in vivo of hydrogenase-catalysed hydrogen evolution in the presence of nitrogenase enzyme in cyanobacteria.	a method was devised that allows measurement in vivo of hydrogenase-catalysed h2 evolution from the cyanobacterium anabaena cylindrica, independent of nitrogenase activity, which is also present. addition of low concentrations of reduced methyl viologen (1-10mm) to intact heterocystous filaments of the organism resulted in h2 evolution, but produced conditions giving total inhibition of nitrogenase (acetylene-reducing and h2-evolving) activity. that the h2 formed under these conditions was not c ...	1979	106842
investigation of the organization of rhodopsin in the sheep photoreceptor membrane by using cross-linking reagents.	the organization of rhodopsin in the photoreceptor membrane of sheep rod outer segments was investigated by using a variety of bifunctional reagents. of the nine reagents used, seven gave oligomeric opsin species, whereas two, copper phenanthroline and dithiobisphenyl azide, failed to cross-link the protein. in general, the cross-linked species obtained showed diminishing yields from dimer to tetramer, together with some higher-molecular-weight aggregates. it is proposed that the patterns of cro ...	1979	106845