Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| fatal pneumocystis carinii in an adolescent with systemic lupus erythematosus. | we report the case of a 16-year-old female who developed pulmonary infection due to pneumocystis carinii within 3 months of the clinical diagnosis of systemic lupus erythematosus (sle). steroid therapy doses never exceeded prednisone 40 mg/day, and no cytotoxic drugs were used. the case presents several unique aspects of importance to clinicians caring for adolescents with sle. | 1989 | 2606762 |
| the larynx of roaring and non-roaring cats. | dissections were made of the larynges of 14 species of the cat family, with representative specimens from all genera. it was found that the vocal folds of the larynx of genus panthera (with the exception of the snow leopard) form the basic structure of a sound generator well-designed to produce a high acoustical energy. combined with an efficient sound radiator (vocal tract) that can be adjusted in length, a panthera can use its vocal instrument literally to blow its own horn with a 'roar'. also ... | 1989 | 2606766 |
| membrane segregation in atrioventricular nodal myocytes of the golden hamster (mesocricetus auratus). a cytochemical study using filipin and tomatine. | the membrane systems of hamster general atrial and ventricular myocytes were studied and their reactivity with the sterol probes, filipin and tomatine, compared with that of atrioventricular nodal myocytes. the sarcolemma of atrial and atrioventricular nodal myocytes was considerably more reactive to sterol probes than the sarcolemma of general ventricular myocytes. atrial myocyte sarcolemma was also more reactive than previously reported in rat atrial myocytes. particle-free regions of annular ... | 1989 | 2606769 |
| a somatic cell hybrid mapping panel for regional assignment of human chromosome 13 dna sequences. | we have constructed somatic cell hybrids containing different overlapping deletions involving human chromosome 13. cytogenetic characterisation of the breakpoints allowed division of the chromosome into six distinct regions. molecular characterisation of these hybrids allowed regional assignment of anonymous dna sequences, cdnas, and isoenzyme variants and these hybrids should prove valuable in the analysis and isolation of genes and disease loci on chromosome 13. | 1989 | 2612208 |
| a somatic cell hybrid mapping panel for regional assignment of human chromosome 13 dna sequences. | we have constructed somatic cell hybrids containing different overlapping deletions involving human chromosome 13. cytogenetic characterisation of the breakpoints allowed division of the chromosome into six distinct regions. molecular characterisation of these hybrids allowed regional assignment of anonymous dna sequences, cdnas, and isoenzyme variants and these hybrids should prove valuable in the analysis and isolation of genes and disease loci on chromosome 13. | 1989 | 2612208 |
| effects of postnatal dexamethasone treatment on development of alveoli in adult rats. | we compared the effects of dexamethasone given to rats from age 4 to 14 days, on alveolar development at age 99 days. judged by similar nose-to-tail length and body weight, somatic growth was not altered by dexamethasone treatment. lung volumes in both air- and saline-filled lungs and mean chord length (lm) were increased, whereas alveolar surface area (sa) and surface-to-volume ratio (s/v) were diminished in dexamethasone-treated adult rats. these changes were associated with a significant redu ... | 1989 | 2612450 |
| effects of postnatal dexamethasone treatment on development of alveoli in adult rats. | we compared the effects of dexamethasone given to rats from age 4 to 14 days, on alveolar development at age 99 days. judged by similar nose-to-tail length and body weight, somatic growth was not altered by dexamethasone treatment. lung volumes in both air- and saline-filled lungs and mean chord length (lm) were increased, whereas alveolar surface area (sa) and surface-to-volume ratio (s/v) were diminished in dexamethasone-treated adult rats. these changes were associated with a significant redu ... | 1989 | 2612450 |
| human lung membrane-bound neutral metallo-endopeptidase-catalyzed hydrolysis of bradykinin. | human lung membrane-bound neutral metallo-endopeptidase (nme; ec 3.4.24.11) has been purified; this enzyme occurred in two forms, nme-i and nme-ii. the total nme activity was purified 2,143-fold with the final specific activities for nme-i and nme-ii being 750 and 1,124, respectively. the two nme forms were resolved in the final purification step involving ion exchange; in all earlier steps including gel filtration and affinity chromatography (phenyl sepharose) both forms behaved similarly and e ... | 1989 | 2612455 |
| human lung membrane-bound neutral metallo-endopeptidase-catalyzed hydrolysis of bradykinin. | human lung membrane-bound neutral metallo-endopeptidase (nme; ec 3.4.24.11) has been purified; this enzyme occurred in two forms, nme-i and nme-ii. the total nme activity was purified 2,143-fold with the final specific activities for nme-i and nme-ii being 750 and 1,124, respectively. the two nme forms were resolved in the final purification step involving ion exchange; in all earlier steps including gel filtration and affinity chromatography (phenyl sepharose) both forms behaved similarly and e ... | 1989 | 2612455 |
| autosomal dominant retinitis pigmentosa: exclusion of a gene from extensive regions of chromosomes 6, 13, 20, and 21. | members of a large pedigree of irish origin presenting with early onset type i autosomal dominant retinitis pigmentosa (adrp) have been typed for polymorphic dna markers from chromosomes 6, 13, 20, and 21. for each marker close linkage to adrp has been excluded by pairwise analyses. using distances fixed from well-established genetic maps of these chromosomes and multipoint analyses with two or three contiguous markers, exclusion of adrp was extended to the areas between markers, resulting in th ... | 1989 | 2613243 |
| repair of experimental arteriotomy in rabbit aorta using a new resorbable elastin-fibrin biomaterial. | a new artificial connective matrix which results from two reactions of fibrinogen and fibronectin on elastin was used to obturate a slit made in the abdominal aorta of rabbit. the so-called elastin-fibrin biomaterial behaved as a scaffold through which all the different structures were restored to their former condition. at 3 months, the material had disappeared and no thrombus, no inflammation or reject had been detected. | 1989 | 2621215 |
| augmentation of recombinant interleukin-2-dependent murine macrophage-mediated tumour cytotoxicity by recombinant tumour necrosis factor-alpha. | the activation of murine macrophages by recombinant human interleukin-2 (rh-il-2) alone or in combination with recombinant human tumour necrosis factor-alpha (rh-tnf) was studied. mouse peritoneal exudate macrophages were activated in vitro to the tumouricidal state. macrophage treatment with rh-il-2 alone slightly enhanced cytotoxic activity against b16 melanoma cells. synergism was observed when macrophages were treated with rh-il-2 and rh-tnf, either when applied sequentially or when both age ... | 1989 | 2625358 |
| the rat 78,000 dalton glucose-regulated protein (grp78) as a precursor for the rat steroidogenesis-activator polypeptide (sap): the sap coding sequence is homologous with the terminal end of grp78. | based on the striking sequence identity between the amino acid sequence of rat steroidogenesis-activator polypeptide (sap) and the carboxyl terminus of the 78,000 dalton glucose-regulated protein (grp78), the precursor-product relationship between grp78 and sap was investigated in leydig cells. immunoblot analysis with peptide antibodies specific for grp78 and sap showed that the putative sap precursor is also immunoreactive with the anti-grp78 antibody. genomic blot hybridizations further revea ... | 1989 | 2628731 |
| transfer and function of t-dna genes from agrobacterium ti and ri plasmids in plants. | 1989 | 2643473 | |
| anomalous drainage of the inferior vena cava into a left atrial connection: a case report involving a 41-year-old man. | a 41-year-old man had an anomalous inferior vena cava directly connected to the left atrium demonstrated by contrast echocardiography, magnetic resonance imaging, angiography, and at operation. the anomaly is due to developmental failure of the right sinus venosus valve, septum secundum, and dorsal portion of the atrial septum. | 1989 | 2650882 |
| esculetin inhibits t cell activation without suppressing il-2 production or il-2 receptor expression. | esculetin (6,7-dihydroxycoumarin) was found to inhibit dose-dependently the proliferation of human t cells stimulated by pha or phorbolester plus ionomycin. proliferation in autologous and allogeneic mlr and generation of cytotoxic t cells under limiting dilution conditions were also suppressed, with more than 90% inhibition seen at 50 microm esculetin. the immunosuppressive effect of esculetin was not due to toxicity. esculetin did not inhibit interleukin-2 (il-2) production, nor did it interfe ... | 1989 | 2654016 |
| heterologous signal peptide processing in fusion interferon synthesis by engineered l-forms of proteus mirabilis. | a recombinant dna proteus mirabilis l-form expression system, lvi (pjs127), was used to synthesize human fusion interferon alpha 1 (f-ifn-alpha 1). in the expression plasmid used, the complete coding sequence of ifn-alpha 1 was linked to the streptococcal spea promoter and the 5' end of the spea structural gene including its signal sequence coding region. lvi (pjs127) was capable of complete secretion into the culture medium of biologically active f-ifn-alpha 1 whose identity was confirmed by im ... | 1989 | 2661322 |
| nasal obstruction and human communication. | nasal obstruction may cause a variety of communication disorders, particularly in children. the effects of nasal obstruction on hearing, speech, language, and voice are examined. methods for assessing the effects of nasal obstruction are delineated, and recommendations for therapeutic interventions are described. | 1989 | 2664661 |
| acute diarrhea in children. | acute diarrhea is a common problem in children. understanding the different pathologic processes that cause diarrhea, and the agents that are associated with those processes, can aid the clinician in predicting the etiology of the diarrhea in an individual patient. small bowel involvement, most commonly caused by rotavirus, produces a high incidence of vomiting, often before the onset of diarrhea, and large, watery, and relatively infrequent stools. large bowel involvement, usually due to campyl ... | 1989 | 2664748 |
| mutations in the sac1 gene suppress defects in yeast golgi and yeast actin function. | the budding mode of saccharomyces cerevisiae cell growth demands that a high degree of secretory polarity be established and directed toward the emerging bud. we report here our demonstration that mutations in sac1, a gene identified by virtue of its allele-specific genetic interactions with yeast actin defects, were also capable of suppressing sec14 lethalities associated with yeast golgi defects. moreover, these sac1 suppressor properties also extended to sec6 and sec9 secretory vesicle defect ... | 1989 | 2687291 |
| current management of salivary gland tumors. part 2. | the authors base their treatment of salivary gland malignancies on the size of the primary and the histopathologic diagnosis. group 1 includes smaller tumors in the t1 and t2 classification with cell types that are associated with slow growth. a parotidectomy is usually sufficient therapy for tumors in this group. group 2 contains t1 and 2 tumors with more aggressive behavior. total parotidectomy is indicated here, with postoperative radiotherapy. t3 tumors and patients with nodal metastasis or ... | 1989 | 2701414 |
| a light microscopic and autoradiographic study of non-irradiated and irradiated ocular wounds. | focal gamma irradiation was used to limit the intraocular extension of scar tissue which typically occurs after posterior perforating injury to the eye. standard posterior perforating injuries were created in the right eye of forty-eight rabbits, half of which had the site of perforation focally irradiated using a cobalt 60 ophthalmic plaque. non-irradiated wounds healed with profuse formation of highly cellular and vascularised granulation tissue which invaded the vitreous to form contractile v ... | 1989 | 2721224 |
| a light microscopic and autoradiographic study of non-irradiated and irradiated ocular wounds. | focal gamma irradiation was used to limit the intraocular extension of scar tissue which typically occurs after posterior perforating injury to the eye. standard posterior perforating injuries were created in the right eye of forty-eight rabbits, half of which had the site of perforation focally irradiated using a cobalt 60 ophthalmic plaque. non-irradiated wounds healed with profuse formation of highly cellular and vascularised granulation tissue which invaded the vitreous to form contractile v ... | 1989 | 2721224 |
| sudden infant death and immunization: an extensive epidemiological approach to the problem in france--winter 1986. | in march 1986 five sudden infant deaths were reported, following the diphtheria-tetanus toxoids-pertussis and inactivated poliomyelitis virus (dtp-ipv) immunization of the infants concerned. an epidemiological study was carried out in order to investigate the possibility of a relationship between this immunization and sudden infant death syndrome (sids). a detailed examination of the five cases had been carried out by a doctor. an exhaustive survey of all postneonatal deaths occurring between ja ... | 1989 | 2722354 |
| stimulation of enzymatic activity in filament preparations of casein kinase ii by polylysine, melittin, and spermine. | casein kinase ii (ckii) has been purified from bovine heart tissue. under conditions of low salt (0.05 m nacl, 10 mm mgcl2), ckii forms structured aggregates that appear as filaments similar to results obtained with drosophila ckii [c.v.c. glover (1986) j. biol. chem. 261:14349]. the aggregates have been analyzed by sucrose density gradients and electron microscopy. filament preparations of the enzyme have reduced but measurable kinase activity. the addition of salt restores activity. various mo ... | 1989 | 2725485 |
| levels of airborne man-made mineral fibres in dwellings in the uk: results of a preliminary survey. | levels of airborne man-made mineral fibres (mmmf) were measured during the insulation of lofts and after the disturbance of the insulation wools. transmission electron microscopy was used for the analysis. generally, the personal samples showed fibre levels of up to 0.7 f/ml, whereas static samples showed fibre levels of 0.05 f/ml in the lofts. little contamination of living space occurred during these operations. | 1989 | 2744831 |
| ulex europeus agglutinin i binds exclusively to primary olfactory neurons in the rat nervous system. | lectin binding histochemistry was used to investigate the distribution of binding sites for the fucose-selective lectin ulex europeus agglutinin i in the rat nervous system. it was found that this lectin bound exclusively to a surface membrane component, probably a glycoprotein, on primary olfactory and vomeronasal sensory neurons, and to no other structure in the nervous system. a similar pattern of ulex europeus agglutinin i binding was found in adult, immature and embryonic rats. binding was ... | 1989 | 2747905 |
| inhalation teratology study on hexachloro-1,3-butadiene in rats. | pregnant rats were exposed to 0, 2, 5, 10 or 15 ppm hexachloro-1,3-butadiene (hcbd) 6 h/d during days 6-20 of gestation. maternal reproduction and fetal parameters were evaluated on gestational day 21. a significant reduction in maternal weight gain and in fetal body weight occurred at 15 ppm. the incidences of external, visceral and skeletal alterations were not significantly increased in any of the hcbd-exposed groups. it is concluded that exposure of pregnant rats to hcbd by inhalation of con ... | 1989 | 2749768 |
| brain angiotensin: critical role in the ongoing regulation of body fluid homeostasis and cardiovascular function. | the existence of an endogenous brain-angiotensin system and its association with cardiovascular and body water regulation has been recognized for over a decade. nevertheless, the importance of the brain-angiotensin system to the instantaneous regulation of these processes has not been firmly established. a 5-minute intracerebroventricular (icv) infusion of the angiotensin antagonist, [sar1,thr8]-aii, effectively lowered the blood pressure in normotensive rats. additionally, application of the se ... | 1989 | 2755868 |
| [infection caused by paracoccidioides brasiliensis in people living in cocle and veraguas, republic of panamá]. | intradermal application of yeast phase paracoccidioidin antigen obtained by sonication and lysis from the fungus to 111 residents of veraguas province (68 men and 43 women) and 130 cocle province residents (57 men and 73 women) elicited a positive reaction in 9.01% (1/111) and 26.15% (34/30) of the veraguas and cocle residents respectively. positive reactions ranged between papules of 5 and 27 mm in diameter, the majority being between 11 and 20 mm. infection was more frequent in men (1:1.47 for ... | 1989 | 2762594 |
| developmental alternations in offspring of female rats orally intoxicated by aluminum chloride or lactate during gestation. | the oral treatment of pregnant rats by aluminum chloride or lactate at various doses was applied from day 1 to day 21 of gestation to determine its influence on mortality, weight evolution, and neuromotor maturation of their pups. no effect of treatment on litter size was detected, but an increased mortality appeared during the first week: treatment by aluminum lactate was less active than was an equivalent treatment by aluminum chloride. weight was transitorily delayed, but the reversal of this ... | 1989 | 2763207 |
| treatment of childhood bacterial meningitis with ceftriaxone once daily: open, prospective, randomized, comparative study of short-course versus standard-length therapy. | fifty-two children were included in this study to evaluate and compare short- versus standard-length ceftriaxone therapy for bacterial meningitis. the duration of the short-course regimens was 4, 6 and 7 days for neisseria meningitidis, hemophilus influenzae and streptococcus pneumoniae, respectively. the standard-length regimens were twice as long. on the basis of a computer-generated randomization list, 26 children were assigned either to the short- or to the standard-treatment regimen. ceftri ... | 1989 | 2766869 |
| combined gastric pull-up and microvascular jejunal transfer procedure after pharyngolaryngoesophagectomy. | a case of simultaneous carcinomas of the lower thoracic esophagus and the oropharynx in a 62-year-old man is reported. reconstruction was successfully performed using a one-stage operation consisting of pharyngolaryngoesophagectomy followed by a combination of gastric pull-up and microvascular jejunal transfer procedures. the postoperative course was uneventful except for regurgitation of food, which persisted for 1 month. | 1989 | 2774731 |
| ductus diverticulum aneurysm and coronary stenosis: repair using circulatory arrest. | the case of a 68-year-old man with advanced symptomatic coronary artery disease and large aneurysm of the diverticulum of the ductus arteriosus is presented. both the coronary artery disease and the aneurysm were successfully repaired at the same time via median sternotomy using cardiopulmonary bypass and a brief period of profound hypothermic circulatory arrest. to our knowledge, this is the 27th reported case of such an aneurysm in an adult. | 1989 | 2774734 |
| smokeless tobacco use and oral epithelial dysplasia. | one hundred eight patients with a histologically confirmed diagnosis of epithelial dysplasia of the oral cavity and a prior history of smokeless tobacco (st) usage were identified. the mean age at time of diagnosis for female patients was almost a decade later than for male patients (63.6 versus 51.2 years). in addition, women were more likely (p = 0.02) to have moderate or severe epithelial dysplasia than men. the two most common locations (buccal mucosa/vestibule and alveolar ridge/gingiva) ac ... | 1989 | 2776112 |
| electron microscopic study of subcutaneous and intraperitoneal splenules in the mouse. | the development of splenules derived from slices of freshly removed autologous spleen implanted subcutaneously or intraperitoneally was followed by light and electron microscopy from day 2 to day 70. within 48 hr after transplantation, a rough space filled with blood, unlined by endothelium, formed just under the surface of the splenic fragment. the tissue central to this vascular space was disrupted and necrotic. in the outer portion of the vascular space, fibroblasts appeared and created locul ... | 1989 | 2782279 |
| first-pass uptake of verapamil, diazepam, and thiopental in the human lung. | the first-pass uptake of verapamil, diazepam, and thiopental in the human lung was determined using multiple-indicator dilution techniques. these three drugs represent lipid-soluble agents that differ in their ionic characteristics at physiological ph. verapamil, a basic lipophilic amine, underwent significant uptake, with 50% of the drug accumulating in lung tissue during the first pass. with diazepam, a nonbasic lipophilic amine, there was 30% uptake during the first pass through the human lun ... | 1989 | 2782646 |
| [changes in the age of illness onset in cancer of the hypopharynx and larynx since 1960. the epidemiologic context in austria]. | between 1960 and 1987, 1567 laryngeal and hypopharyngeal carcinomas were diagnosed at the first ent clinic of vienna university. patients under 50 years of age increased steadily in number and proportion. three subgroups of carcinomas were considered: glottic (including subglottic), supraglottic and hypopharyngeal. a total of 1442 cases could be studied in detail. in the supraglottic and hypopharyngeal groups the proportion under 50 years of age rose significantly, whereas in the glottic cases n ... | 1989 | 2785098 |
| human fetal dopamine neurons grafted into the striatum in two patients with severe parkinson's disease. a detailed account of methodology and a 6-month follow-up. | by using stereotaxic surgical techniques, ventral mesencephalic tissues from aborted human fetuses of 8 to 10 weeks' gestational age were implanted unilaterally into the striata in two patients with advanced parkinson's disease. the patients were treated with a cyclosporine, azathioprine, and steroid regimen to minimize the risk for graft rejection. they were examined for 6 months preoperatively and 6 months postoperatively and continued to receive the same doses of antiparkinsonian medication. ... | 1989 | 2786405 |
| in-vitro activity of a new penem fce 22101. | the in-vitro activity of a new penem fce 22101 was evaluated in comparison with other antimicrobial agents against 966 aerobic and anaerobic gram-negative and gram-positive bacteria. fce 22101 inhibited 90% of enterobacteriaceae, haemophilus influenzae, h. parainfluenzae, h. ducreyi, neisseria gonorrhoeae, branhamella catarrhalis, staphylococcus aureus, staph. epidermidis and group b streptococcus at concentrations of 0.12-4.0 mg/l. pseudomonas aeruginosa was resistant with mic90 of greater than ... | 1989 | 2786518 |
| morphological and immunological characteristics of a rat choriocarcinoma. | a post-gestational rat choriocarcinoma has been studied for its immunological and morphological characteristics. the tumor can be transplanted in syngeneic (wka/h rats) as well as in allogeneic rats (bn, r/a). even after immunization of the allogeneic hosts with tissues of the wka/h rats, the development of the tumor was not inhibited. this neoplasm is composed of giant cells, surrounding spaces filled with blood, and of proliferating cytotrophoblasts. ultrastructurally, these cells are very sim ... | 1989 | 2479608 |
| purification of high and low molecular weight plasminogen activator inhibitor 1 from fibrosarcoma cell-line ht 1080 conditioned medium. | functionally active (high-mr) and inactive (low-mr) plasminogen activator inhibitor 1 (pai) have been purified from fibrosarcoma cell-line ht 1080 conditioned medium, containing 1% fetal calf serum. the two forms were first purified by affinity chromatography on heparin-sepharose and then separated from each other by gel filtration on sephadex g-150. the final purification was achieved by affinity chromatography on insolubilized monoclonal antibodies towards human pai. alternatively, the low-mr ... | 1989 | 2493266 |
| intraretinal transplantation for rod-cell replacement in light-damaged retinas. | blindness from retinal disease is often the consequence of extensive damage to the photoreceptor cell population, while other cell types which form the neural retina are relatively spared. in this setting, transplantation of photoreceptor cells could offer hope for the restoration of some degree of visual function. we tested the feasibility of this approach by transplanting immature retinal cells into the eyes of adult rats affected by late stage phototoxic retinopathy, which are almost totally ... | 1989 | 2519517 |
| seroepidemiological study of infectious mononucleosis in older patients. | in southern tasmania, australia, primary epstein-barr virus infection occurs in adults greater than 30 years of age at a higher frequency (approximately 13% of all cases) than is generally reported for other parts of the world, and approximately 7% of the general population of the region have no antibodies to the virus. epstein-barr virus should not be overlooked as a possible cause of disease in older patients in similar populations elsewhere. | 1989 | 2536757 |
| role of monokines in altering receptor and non-receptor mediated vascular contraction in sepsis. | 1989 | 2538847 | |
| effect of distance and orientation between arginine-302, histidine-322, and glutamate-325 on the activity of lac permease from escherichia coli. | lac permease of escherichia coli was modified by site-directed mutagenesis in order to investigate the effects of polarity, distance, and orientation between the components of a putative h+ relay system (arg302/his322/glu325) postulated to be involved in lactose-coupled h+ translocation. the importance of polarity between his322 and glu325 was studied by interchanging the residues, and the modified permease--h322e/e325h--is inactive in all modes of translocation. the effect of distance and/or or ... | 1989 | 2567182 |
| proton nmr and cd solution conformation determination and opioid receptor binding studies of a dynorphin a(1-17) model peptide. | the opioid peptide dynorphin a(1-17) contains a peptide segment in residues 7-15 with the potential to form an amphiphilic beta-strand. this amphiphilic structure may, like the amphiphilic alpha-helices found in many other peptide hormones, be an important determinant of its interactions with membranes and receptors. in order to investigate and characterize these interactions, we have synthesized a 17-residue dynorphin analogue (yggflkkvkpkvkvkss) that incorporates a peptide model of this amphip ... | 1989 | 2574597 |
| [pharmacologic bases of antihypertensive drugs with mechanisms of multi-factor action]. | 1990 | 1971122 | |
| [differential roentgenological diagnosis of injuries of the lower cervical vertebrae]. | on the basis of 14 experiments with simulation of the lower cervical vertebra dislocations on cadavers and human cervical vertebra blocks, combined with stage discography, the authors singled out 3 groups of +disk and ligament structure damages: damage of capsular--ligamentous apparatus of the rear support complex; damage of ligamentous--capsular apparatus and disk; damage of ligamentous-capsular apparatus, frontal longitudinal ligament and total rupture of a disk. differentiation is made accord ... | 1990 | 2074961 |
| [recurrent thromboembolism disclosing protein c deficiency. apropos of a case with familial investigation]. | every thromboembolic manifestation, especially in young subjects, calls for an aetiological study in which haemostasis is evaluated primarily with assays of physiological coagulation inhibitors: protein c, protein s and antithrombin iii. protein c deficiency is found in 6 to 7% of thromboembolic manifestations. we report the case of a 21-year old man who had phlebitis followed by pulmonary embolism without facilitating factors. protein c level was 50% of normal value (0.50 iu/ml). the patient re ... | 1990 | 2075365 |
| change in ovarian arterial compliance during the human menstrual cycle assessed by doppler ultrasound. | 1990 | 2223695 | |
| change in ovarian arterial compliance during the human menstrual cycle assessed by doppler ultrasound. | 1990 | 2223695 | |
| [effect of enalapril on heart rate, arterial blood pressure and exocrine pancreatic secretion in the alert dog]. | a changed exocrine pancreatic secretion could be a pathogenetic factor of an acute pancreatitis after administration of angiotensin-converting enzyme (ace) inhibitors. in six conscious dogs with gastric and duodenal thomas fistulas we studied the effect of an intravenous (iv.) bolus injection of 10 mg enalaprilat, an intraduodenal (id.) bolus injection of 20 and 40 mg enalapril (e.), and 0.15 m nacl (20 ml iv., resp., id.) on pancreatic bicarbonate- and protein output in response to secretin (20 ... | 1990 | 2238764 |
| staphylococcus aureus infection of human endothelial cells potentiates fc receptor expression. | vasculitis, a recognized complication of staphylococcal-endovascular infections, may result in part, from the expression of fcr by staphylococcus aureus-infected endothelial cells. fcr were measured using [51]cr labeled srbc preincubated with rabbit anti-srbc igg. fcr were not detected on uninfected endothelial cells, but were demonstrated on s. aureus infected cells using igg, but not igm labeled srbc. fcr expression was dependent on the initial bacterial density (greater than or equal to 8 x 1 ... | 1990 | 2258617 |
| induction of carcinoembryonic-antigen-gene expression in human colorectal carcinoma by sodium butyrate. | the effect of sodium butyrate on the expression of the carcinoembryonic-antigen (cea) gene was studied in two poorly differentiated colorectal-carcinoma cell lines (clone-a and mip-101) and in one well-differentiated cell line (ls-174t); a.t.c.c. no. ccl 188). northern-blot and dot-blot analyses indicated a steady increase in cea mrna from day 4 to a maximal level by day 14 after these cells were exposed to 2 mm-sodium butyrate. studies using nuclear run-off assays followed by dot-blot hybridiza ... | 1990 | 2268282 |
| transcriptional activation and dna binding by the erythroid factor gf-1/nf-e1/eryf 1. | the murine, erythroid dna-binding protein gf-1 (also known as nf-e1, eryf 1), a 413-amino acid polypeptide with two novel finger domains of the cx-cx variety, recognizes a consensus gata motif present in cis elements of the majority of erythroid-expressed genes. we have performed a structure-function analysis of this protein to evaluate its potential as a transcriptional activator and to examine the role of the finger domains in dna binding. using a cotransfection assay, we find that gf-1 is a p ... | 1990 | 2276623 |
| transcriptional activation and dna binding by the erythroid factor gf-1/nf-e1/eryf 1. | the murine, erythroid dna-binding protein gf-1 (also known as nf-e1, eryf 1), a 413-amino acid polypeptide with two novel finger domains of the cx-cx variety, recognizes a consensus gata motif present in cis elements of the majority of erythroid-expressed genes. we have performed a structure-function analysis of this protein to evaluate its potential as a transcriptional activator and to examine the role of the finger domains in dna binding. using a cotransfection assay, we find that gf-1 is a p ... | 1990 | 2276623 |
| glucocorticoid stimulation of fatty acid synthesis in explants of human fetal lung. | we examined the effects of glucocorticoids and thyroid hormone (t3) on fatty acid synthesis, fatty acid composition and fatty acid synthetase activity in explants of human fetal lung (16-23 wk gestation). explants were cultured 1-7 days in the absence (control) or presence of dexamethasone (10 nm) and/or t3 (2 nm). in control explants fatty acid synthesis and fatty acid synthetase activity increased 200% and 455%, respectively, between 1 and 5 days. dexamethasone (10 nm) stimulated fatty acid sy ... | 1990 | 2297514 |
| formation of a nitro derivative of 2-amino-3,4-dimethylimidazo[4,5-f]quinoline by photo-irradiation. | a direct-acting mutagen to salmonella typhimurium ta98 was found to be formed by exposing 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (meiq) in acetone to sunlight for 60 min. the direct-acting mutagen in the irradiated sample was purified by hplc and identified as 3,4-dimethyl-2-nitroimidazo-[4,5-f]quinoline (no2-meiq). the yield of no2-meiq from meiq was estimated to be 0.3%. | 1990 | 2335014 |
| atypical presentation of chancroid in a patient infected with the human immunodeficiency virus. | 1990 | 2368772 | |
| aids--an interview with ole morten nygaard who is hiv positive. interview by marie farrell and richard wells. | 1990 | 2394895 | |
| human prolactin gene expression. the use of an alternative noncoding exon in decidua and the im-9-p3 lymphoblast cell line. | the prolactin (prl) gene is normally expressed in the anterior pituitary lactotrope and the decidualized stromal cell of the human endometrium. we have recently described the ectopic expression of the human prl gene in a b-lymphoblastoid cell line, im-9-p. the im-9-p and decidual prl mrnas are approximately 150 nucleotides longer than the pituitary transcript. the protein coding sequence of the im-9-p and decidual prl cdnas is identical to the pituitary prl message, and the 3'-untranslated regio ... | 1990 | 1697858 |
| human prolactin gene expression. the use of an alternative noncoding exon in decidua and the im-9-p3 lymphoblast cell line. | the prolactin (prl) gene is normally expressed in the anterior pituitary lactotrope and the decidualized stromal cell of the human endometrium. we have recently described the ectopic expression of the human prl gene in a b-lymphoblastoid cell line, im-9-p. the im-9-p and decidual prl mrnas are approximately 150 nucleotides longer than the pituitary transcript. the protein coding sequence of the im-9-p and decidual prl cdnas is identical to the pituitary prl message, and the 3'-untranslated regio ... | 1990 | 1697858 |
| trapping of oncornavirus particles at the surface of interferon-treated cells. | 1990 | 183369 | |
| lower incisor extraction in orthodontic treatment. | the extraction of a single mandibular incisor can be employed as a compromise treatment of certain malocclusions, if the end result fulfills the requirements for a healthier dentition which is functionally and esthetically harmonized in relation to the surrounding structures. indications, contraindications, and the procedure of treatment have been presented. class i malocclusions with normal maxillary dentition and good buccal interdigitation in which there is severe lower anterior crowding are ... | 1991 | 270288 |
| analysis of high psa n-cam expression during mammalian spinal cord and peripheral nervous system development. | using a monoclonal antibody that recognizes specifically a high polysialylated form of n-cam (high psa n-cam), the temporal and spatial expression of this molecule was studied in developing spinal cord and neural crest derivatives of mouse truncal region. temporal expression was analyzed on immunoblots of spinal cord and dorsal root ganglia (drgs) extracts microdissected at different developmental stages. analysis of the ratio of high psa n-cam to total n-cam indicated that sialylation and desia ... | 1991 | 1769342 |
| the effect of age on motor neurone death following axotomy in the mouse. | the ability of mouse motor neurones to survive axotomy during the first month of life was studied. the motor neurones that lie in the dorsolateral columns of spinal segments c7 and c8 and supply the flexor muscles of the forepaw were axotomized by cutting and removing part of the median and ulnar nerves above the elbow. the number and position of cell bodies with axons in these nerves were confirmed by retrograde labelling of the cut axons with horseradish peroxidase. the ability of these neuron ... | 1991 | 1769343 |
| effect of spectrin on structure properties of lipid bilayers formed from mixtures of phospholipids. fluorescence and microcalorimetric studies. | effect of spectrin from human erythrocytes on structure properties of lipid bilayers formed from a mixture of phosphatidylethanolamine/phosphatidylserine (pe/ps) and/or phosphatidylethanolamine/phosphatidylcholine (pe/pc) was studied with the use of fluorescence and microcalorimetric methods. spectrin did not affect the order parameter of lipids in pe/ps vesicles. however, spectrin binding to liposomes did influence temperature, half-width and enthalpy of phase transitions in mixtures of dimyris ... | 1991 | 1769515 |
| inhibitory effect of cimetidine on graft survival of allotransplanted rats submitted to an active-passive enhancement protocol. | the objective of the present study was to determine whether cimetidine, a type-2 histamine receptor antagonist, inhibits the immunological enhancement of allografted rats achieved by treatment with donor antigen plus anti-donor antibody. groups of rats submitted to this active-passive enhancement protocol and treated ip with 30 (apec 30; group i; n = 4) or 60 (apec 60; group ii; n = 8) mg/day cimetidine for 14 days had a significantly shorter graft survival (20.2 +/- 5.1 and 11.1 +/- 2.6 days, r ... | 1991 | 1797288 |
| inhibitory effect of cimetidine on graft survival of allotransplanted rats submitted to an active-passive enhancement protocol. | the objective of the present study was to determine whether cimetidine, a type-2 histamine receptor antagonist, inhibits the immunological enhancement of allografted rats achieved by treatment with donor antigen plus anti-donor antibody. groups of rats submitted to this active-passive enhancement protocol and treated ip with 30 (apec 30; group i; n = 4) or 60 (apec 60; group ii; n = 8) mg/day cimetidine for 14 days had a significantly shorter graft survival (20.2 +/- 5.1 and 11.1 +/- 2.6 days, r ... | 1991 | 1797288 |
| endothelium-dependent mesenteric vasorelaxant effects and systemic actions of endothelin (16-21) and other endothelin-related peptides in the rat. | 1. the rat isolated superior mesenteric bed, perfused with krebs-henseleit solution containing 10 microm indomethacin and precontracted with 100 microm methoxamine, was used to study the vasorelaxation produced by some fragments of endothelin-1, by two alanyl-substituted analogues, and by human and porcine proendothelins. the systemic cardiovascular effects of some of these peptides were also studied in anaesthetized rats. 2. endothelin (16-21) was an endothelium-dependent vasodilator about 10 t ... | 1991 | 1797300 |
| endothelium-dependent mesenteric vasorelaxant effects and systemic actions of endothelin (16-21) and other endothelin-related peptides in the rat. | 1. the rat isolated superior mesenteric bed, perfused with krebs-henseleit solution containing 10 microm indomethacin and precontracted with 100 microm methoxamine, was used to study the vasorelaxation produced by some fragments of endothelin-1, by two alanyl-substituted analogues, and by human and porcine proendothelins. the systemic cardiovascular effects of some of these peptides were also studied in anaesthetized rats. 2. endothelin (16-21) was an endothelium-dependent vasodilator about 10 t ... | 1991 | 1797300 |
| the long-term effects of the rodenticide, brodifacoum, on blood coagulation and vitamin k metabolism in rats. | 1. the long-term (30 days) effects of a single dose of brodifacoum (0.2 mg kg-1, orally) on blood clotting activity and on liver parameters of the vitamin k cycle were investigated in rats. maximal effect on blood clotting activity was seen on day one. on day seven blood clotting activity had returned to normal. 2. liver microsomal vitamin ko reductase activity was maximally suppressed (10% of control activity) on day one, steadily recovered to about 40% on day 15 to remain at that level. the sa ... | 1991 | 1797316 |
| the long-term effects of the rodenticide, brodifacoum, on blood coagulation and vitamin k metabolism in rats. | 1. the long-term (30 days) effects of a single dose of brodifacoum (0.2 mg kg-1, orally) on blood clotting activity and on liver parameters of the vitamin k cycle were investigated in rats. maximal effect on blood clotting activity was seen on day one. on day seven blood clotting activity had returned to normal. 2. liver microsomal vitamin ko reductase activity was maximally suppressed (10% of control activity) on day one, steadily recovered to about 40% on day 15 to remain at that level. the sa ... | 1991 | 1797316 |
| [comparative study of culture media for isolating brucella ovis]. | for the isolation of brucella ovis, modified thayer-martin medium with the addition of 0.01 micrograms/ml of trimethoprim and 100 iu of nystatin (tmm) was compared with skirrow agar (sk). using viable counting technique, 11 strains were evaluated and the results were compared with those using columbia base agar with bovine blood 7% (cba). ninety-four semen samples of 33 rams from a flock with infection antecedents were cultured on the same media. growth of brucella ovis strains was similar in al ... | 1991 | 1815277 |
| antipyretic actions of human recombinant lipocortin-1. | the effect of human recombinant lipocortin-1 (hrlc-1) on the pyrogenic actions of the synthetic polyribonucleotide polyinosinic:polycytidylic acid (poly i:c) has been studied in conscious rabbits. poly i:c (2.5 micrograms kg-1) given i.v. produced a biphasic fever with a first peak after 90-105 min and a second peak between 225-240 min. hrlc-1 (50 micrograms kg-1) given i.v. simultaneously with the poly i:c produced a significant reduction in the febrile response but without complete suppression ... | 1991 | 1828384 |
| antipyretic actions of human recombinant lipocortin-1. | the effect of human recombinant lipocortin-1 (hrlc-1) on the pyrogenic actions of the synthetic polyribonucleotide polyinosinic:polycytidylic acid (poly i:c) has been studied in conscious rabbits. poly i:c (2.5 micrograms kg-1) given i.v. produced a biphasic fever with a first peak after 90-105 min and a second peak between 225-240 min. hrlc-1 (50 micrograms kg-1) given i.v. simultaneously with the poly i:c produced a significant reduction in the febrile response but without complete suppression ... | 1991 | 1828384 |
| miniature manipulator with microelectrode for chronic recording of single units from freely-moving animals. | we report a simple recording and stimulating system, a miniature manipulator with a microelectrode (mmm) that can be mounted on animal's skull. the system consists of a miniature manipulator and a microelectrode which are used in one body. several mmms can be implanted simultaneously into the brain as the part of the manipulator is small. with this device, recording of single units from several different cortices is possible from awake and unrestricted animals. | 1991 | 1851979 |
| interaction of butorphanol, with monoamine oxidase inhibitor, tranylcypromine. | this investigation examines the possibility of interaction between tranylcypromine and butorphanol in comparison to pethidine. the ld50 of pethidine and butorphanol were determined in mice pretreated with the non-selective monoamine oxidase (mao) inhibitor, tranylcypromine orally for 8 days or with oral saline solution. tranylcypromine decreased the ld50 of both pethidine and butorphanol by 78% and 41%, respectively. anesthetized rabbits with halothane pretreated with tranylcypromine or saline w ... | 1991 | 1855717 |
| interaction of butorphanol, with monoamine oxidase inhibitor, tranylcypromine. | this investigation examines the possibility of interaction between tranylcypromine and butorphanol in comparison to pethidine. the ld50 of pethidine and butorphanol were determined in mice pretreated with the non-selective monoamine oxidase (mao) inhibitor, tranylcypromine orally for 8 days or with oral saline solution. tranylcypromine decreased the ld50 of both pethidine and butorphanol by 78% and 41%, respectively. anesthetized rabbits with halothane pretreated with tranylcypromine or saline w ... | 1991 | 1855717 |
| relevance of n-nitrosamines to oesophageal cancer in china. | oesophageal cancer occurs at a very high frequency in certain areas of china, especially in linxian county, henan province. previous studies suggested that n-nitroso compounds play a causative role. in order to study further the exposure of linxian inhabitants, the intake of n-nitrosamines in the diet was determined. the total daily intake of volatile nitrosamines and of n-nitroso-n-methylbenzylamine (nmbza) was higher in linxian than in two other counties. nmbza can induce cancer in animal and ... | 1991 | 1855832 |
| modulation of genotoxic activity of tobacco smoke. | tobacco smoke (ts) caused a three- to nine-fold increase in the frequency of his+ revertants in salmonella typhimurium ta98 but not in ta97a, ta100 or ta102. activation by a post-mitochondrial fraction obtained from the liver of rats pretreated with aroclor-1254 or methylcholanthrene was required; fractions from phenobarbital-pretreated or untreated rats had no effect. vitamins a and e, but not ascorbic acid, inhibited the ts-induced mutagenesis by up to 63%, whereas glutathione and cysteine inc ... | 1991 | 1855912 |
| novel cold-sensitive cytosolic 3,5,3'-triiodo-l-thyronine-binding proteins in human red blood cell. isolation and characterization. | four cytosolic 3,5,3'-triiodo-l-thyronine-binding proteins (ctbp) were isolated from hemoglobin-free human erythrocyte on deae-cellulose column by linear gradient of nacl (0-0.4 m). ctbp i, ii, and iv underwent rapid loss of their activities at low temperatures, whereas ctbp iii was cold-insensitive. reactivation of cold-inactivated ctbps by warming was obtained at 20 and 37 degrees c. ctbp i, ii, and iv were not inhibited by thiol-blocking agents, whereas ctbp iii was blocked. scatchard analysi ... | 1991 | 1885573 |
| head group specificity in the regulation of phosphatidylcholine catabolism in rat hepatocytes. | previous studies have shown that the catabolism of pc is regulated in choline-deficient hepatocytes and the concentration of phosphatidylcholine (pc) might be an important regulatory factor (tijburg, l.b.m., nishimaki-mogami, t. and vance, d.e. (1991) biochim. biophys. acta, 1085, 167-177). in the present study we investigated the head group specificity of the regulation of pc catabolism. supplementation of choline-deficient rat hepatocytes, prelabeled with [3h]choline, with dimethylethanolamine ... | 1991 | 1892886 |
| cadmium induction of metallothioneins in several dogfish organs. | dogfish scyliorhinus canicula were exposed to 50 mg/l cd for 4 days for inducing metallothionein synthesis. spleen, pancreas, kidney and gonads were dissected out and metallothionein presence was checked by means of gel filtration chromatography in sephadex g-75 and sodium dodecyl sulphate polyacrylamide electrophoresis. in pancreas and kidney, a cadmium-binding protein with spectroscopical and electrophoretic properties similar to those of dogfish liver metallothionein was found. in the other o ... | 1991 | 1924966 |
| differential induction of acquired resistance and pr gene expression in tobacco by virus infection, ethephon treatment, uv light and wounding. | genes for acidic, extracellular and basic, intracellular pathogenesis-related (pr) proteins of tobacco were studied for their response to tobacco mosaic virus (tmv) infection, ethephon treatment, wounding and uv light. the genes encoding the acidic pr proteins (pr-1, pr-2, pr-3, pr-4 and pr-5) responded similarly to the different forms of stress. they appeared to be highly inducible by tmv, moderately inducible by ethephon treatment and uv light and not inducible by wounding. the genes for the b ... | 1991 | 1932689 |
| protection against hypoxia-induced passive avoidance deficits: interactions between dup 996 and ketanserin. | dup 996 and ketanserin have previously been shown to protect against experimentally induced passive avoidance (pa) deficits. in the present experiment the potential interaction between dup 996 and ketanserin on hypoxia-induced amnesia was evaluated. exposure to hypoxia (6.5% oxygen) produced a reliable deficit in pa retention which was attenuated by posthypoxia treatment with dup 996 (0.01-0.1 mg/kg sc). similar effects were found with ketanserin at 1.0 and 3.0 mg/kg sc. coadministration of keta ... | 1991 | 1933401 |
| orphan drug for hiv wasting syndrome. | 1991 | 1950976 | |
| changes in the spectrum of organisms causing respiratory tract infections: a review. | over the last decade, the spectrum of organisms causing community-acquired acute lower respiratory tract infections has changed. streptococcus pneumoniae now causes approximately 30% of outpatient acute pneumonia-less than in former decades-whereas mycoplasma pneumoniae is found in both young and elderly patients. the enterobacteriaceae and staphylococcus aureus are now seen more frequently as respiratory tract pathogens in community-acquired pneumonia patients, and they are the major organisms ... | 1992 | 1287613 |
| tuberculosis in patients infected with human immunodeficiency virus 1. a retrospective multicentre study of 123 cases in france. the groupe des infectiologues du sud de la france. | in order to study the epidemiological, clinical, and progressive characteristics of tb in hiv-infected individuals, a retrospective study was conducted in nine infectious disease centres of university hospitals located in the southern half of france. among the 5730 hiv-seropositive in- and out-patients, 123 (2.1 per cent) had tb (121 infections caused by m. tuberculosis, 2 by m. bovis). tuberculosis was pulmonary in 53 patients (43.1 per cent), extrapulmonary in 36 patients (29.3 per cent), and ... | 1992 | 1287704 |
| general principles of human genetics. | 1992 | 1301903 | |
| expression and release of neuroregulators during development: monoamines and neuropeptides. | the turnover of catecholamines (ca) was determined in the adrenal medulla and brain of rat fetuses and pups. in general we found a considerable increase soon after birth. the expression of mrna for ca-synthesizing enzymes was also considerably enhanced in the adrenals shortly after birth. furthermore, we demonstrated increased expression of neuropeptides after birth, increased synthesis of mrna encoding for neuropeptide y in the adrenals 24 h after birth; and considerable activation of the subst ... | 1992 | 1306802 |
| inactivated hepatitis a virus vaccines. | 1992 | 1317341 | |
| freeze-dried, cross-linked bovine type i collagen: analysis of properties. | this study was undertaken to assess the physical and biological properties of freeze-dried cross-linked bovine type i collagen and to assess its potential for use in the guided tissue regeneration method of treatment of periodontal disease in human adult subjects. the modulus of elasticity, swelling ratio, and biodegradation rate were investigated. the collagen sponge was implanted subdermally into sprague-dawley rats and a histological study carried out at 2, 7, 21, 35, and 49 days post implant ... | 1992 | 1317425 |
| the pathogenicity of drug-resistant variants of herpes simplex virus. | 1992 | 1317602 | |
| hetrazepine paf antagonists. | hetrazepines such as web-2086 or web-2170 are potent, specific, competitive paf antagonists binding at the same site as the paf molecule. despite their structural similarity to known hypnotic drugs they lack hypnotic actions. they almost certainly bind not only cell-surface but also intracellular paf receptors, which may explain their activity in disease models in which adherence of neutrophils or other cell types to the vascular endothelium plays a role. | 1992 | 1326346 |
| [cognitive ergonomics: use in man-machine systems]. | 1992 | 1343512 | |
| comparative metabolism and disposition of furfural and furfuryl alcohol in rats. | the comparative metabolism and disposition of furfural (fal) and furfuryl alcohol (fol) were investigated following oral administration of approximately 0.001, 0.01, and 0.1 of the ld50, corresponding to approximately 0.127, 1.15, and 12.5 mg/kg for fal and 0.275, 2.75, and 27.5 mg/kg for fol. at all doses studied, at least 86-89% of the dose of fal or fol was absorbed from the gastrointestinal tract. fal and fol were extensively metabolized prior to excretion. the major route of excretion was i ... | 1992 | 1352210 |
| characterization of guanosine diphospho-d-mannose dehydrogenase from pseudomonas aeruginosa. structural analysis by limited proteolysis. | alginate is believed to be a major virulence factor in the pathogenicity of pseudomonas aeruginosa in the lungs of patients suffering from cystic fibrosis. guanosine diphospho-d-mannose dehydrogenase (gdpmannose dehydrogenase, ec 1.1.1.132) is a key enzyme in the alginate biosynthetic pathway which catalyzes the oxidation of guanosine diphospho-d-mannose (gdp-d-mannose) to gdp-d-mannuronic acid. in this paper, we report the structural analysis of gmd by limited proteolysis using three different ... | 1992 | 1370473 |
| mechanisms of action of cicletanine in human and guinea pig resistance arteries. | human subcutaneous (s.c.) arteries and guinea pig mesenteric vessels (internal diameter 150-570 microns) were isolated and mounted on a microvascular myograph. cicletanine-induced relaxation curves were constructed after preconstriction with either depolarising potassium (kpss) or norepinephrine (ne) and in the presence and absence of indomethacin, glibenclamide, or tetraethylammonium chloride (tea). using only guinea pig vessels, cicletanine relaxation curves were constructed with and without c ... | 1992 | 1378119 |